CN114712451A - Additive solution for preventing poultry digestive tract bacterial diseases and preparation method thereof - Google Patents
Additive solution for preventing poultry digestive tract bacterial diseases and preparation method thereof Download PDFInfo
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- CN114712451A CN114712451A CN202210364164.7A CN202210364164A CN114712451A CN 114712451 A CN114712451 A CN 114712451A CN 202210364164 A CN202210364164 A CN 202210364164A CN 114712451 A CN114712451 A CN 114712451A
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- 239000000654 additive Substances 0.000 title claims abstract description 35
- 230000000996 additive effect Effects 0.000 title claims abstract description 35
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 28
- 208000035143 Bacterial infection Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 244000144977 poultry Species 0.000 title claims abstract description 17
- 239000000243 solution Substances 0.000 claims abstract description 41
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 36
- 241000218628 Ginkgo Species 0.000 claims abstract description 35
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 35
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 239000000341 volatile oil Substances 0.000 claims abstract description 19
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 15
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 15
- 239000011718 vitamin C Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 240000002234 Allium sativum Species 0.000 claims abstract description 8
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 8
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 8
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 8
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 8
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 8
- 244000104272 Bidens pilosa Species 0.000 claims abstract description 8
- 235000010662 Bidens pilosa Nutrition 0.000 claims abstract description 8
- 244000124209 Crocus sativus Species 0.000 claims abstract description 8
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- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 8
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- 239000004248 saffron Substances 0.000 claims abstract description 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011259 mixed solution Substances 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 5
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- 239000007788 liquid Substances 0.000 claims abstract description 4
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 9
- RGHNJXZEOKUKBD-QTBDOELSSA-N L-gulonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-QTBDOELSSA-N 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 9
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- 238000010438 heat treatment Methods 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
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- 229910052708 sodium Inorganic materials 0.000 claims description 3
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- 238000000643 oven drying Methods 0.000 claims description 2
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- 230000002265 prevention Effects 0.000 abstract description 6
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- 210000000514 hepatopancreas Anatomy 0.000 description 5
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- 210000004534 cecum Anatomy 0.000 description 1
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- 210000001198 duodenum Anatomy 0.000 description 1
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- 210000001630 jejunum Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 230000008092 positive effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
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Abstract
The invention belongs to the technical field of prevention of poultry digestive tract bacterial diseases, and discloses an additive solution for preventing poultry digestive tract bacterial diseases and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 1 part of ginkgo essential oil, 3 parts of sandalwood, 5 parts of saffron, 8 parts of wormwood, 10 parts of spanishneedles herb, 12 parts of garlic and 9 parts of vitamin C. The preparation method comprises the first step of drying the sandalwood, the saffron, the wormwood, the sticktight and the garlic respectively according to the weight parts of the raw materials, then placing the dried raw materials into a pulverizer to be pulverized, then decocting the pulverized raw materials with purified water, and filtering the decoction to obtain mixed liquid; and step two, after the obtained mixed solution is cooled to normal temperature, adding the ginkgo essential oil and the vitamins in parts by weight of the raw materials, and uniformly mixing to obtain a finished additive solution. The ginkgo essential oil prepared by the preparation method of the ginkgo essential oil has high quality, and the quality of the additive solution is greatly improved; meanwhile, the vitamin C prepared by the preparation method of the vitamin C has high purity, and the prevention effect of the additive solution is greatly improved.
Description
Technical Field
The invention belongs to the technical field of prevention of poultry digestive tract bacterial diseases, and particularly relates to an additive solution for preventing poultry digestive tract bacterial diseases and a preparation method thereof.
Background
The digestive tract is a long muscular tube which extends from the oral cavity to the pharynx, the esophagus, the stomach, the small intestine, the large intestine and the anal canal [1], and comprises the oral cavity, the pharynx, the esophagus, the stomach, the small intestine (duodenum, jejunum and ileum), the large intestine (cecum, appendix, colon and rectum), the anal canal and the like. There are two kinds of digestive glands, a small digestive gland and a large digestive gland. The small digestive gland is located in the wall of each part of the digestive tract, and the large digestive gland has three pairs of salivary glands (parotid gland, submandibular gland and sublingual gland), liver and pancreas, which are all drained into the digestive tract by means of ducts. However, the existing additive solution for preventing the bacterial diseases of the digestive tracts of the poultry and the preparation method thereof adopt poor quality, which causes poor quality of the additive solution; meanwhile, the adopted purity is low, and the prevention effect of the additive solution is influenced.
In summary, the problems of the prior art are as follows: the existing additive solution for preventing poultry digestive tract bacterial diseases and the preparation method thereof adopt poor quality, which causes poor quality of the additive solution; meanwhile, the adopted purity is low, and the prevention effect of the additive solution is influenced.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides an additive solution for preventing poultry digestive tract bacterial diseases and a preparation method thereof.
The invention is realized in such a way that the additive solution for preventing the bacterial diseases of the digestive tracts of the poultry is prepared from the following raw materials in parts by weight:
1 part of ginkgo essential oil, 3 parts of sandalwood, 5 parts of saffron, 8 parts of wormwood, 10 parts of spanishneedles herb, 12 parts of garlic and 9 parts of vitamin C.
A preparation method of an additive solution for preventing poultry digestive tract bacterial diseases comprises the following steps:
firstly, respectively drying sandalwood, saffron, wormwood, sticktight and garlic according to the weight parts of raw materials, then placing the dried raw materials into a pulverizer to be pulverized, then decocting the pulverized raw materials with purified water, and filtering the decoction to obtain a mixed solution;
and step two, after the obtained mixed solution is cooled to normal temperature, adding the ginkgo essential oil and the vitamins in parts by weight of the raw materials, and uniformly mixing to obtain a finished product of the additive solution.
Further, the decoction condition is decoction for 2.5h, and heat preservation is carried out for 31 min.
Further, the preparation method of the ginkgo essential oil comprises the following steps:
1) picking fresh folium Ginkgo and semen Ginkgo, cleaning, sterilizing, and oven drying; uniformly mixing dried ginkgo leaves and ginkgo fruits in a weight ratio of 1:1, crushing, sieving with a 51-mesh sieve, and placing in an extraction kettle;
2) inputting supercritical carbon dioxide fluid into the extraction kettle, and extracting under the condition that the flow rate of carbon dioxide is 61 kg/h;
3) introducing the extracted carbon dioxide fluid into a first-stage separator and a second-stage separator in sequence for separation, wherein the flow rate of the carbon dioxide is 31 kg/h; removing the waxy component from the primary separator; and discharging the ginkgo oil from the secondary separator, heating for demulsification, and separating a water phase to obtain the ginkgo essential oil.
Further, the extraction pressure was 36 MPa.
Further, the extraction temperature was 51 ℃.
Further, the extraction time was 9 h.
Further, the pressure of the primary separator is 7MPa, and the temperature of the primary separator is 16 ℃.
Further, the pressure of the secondary separator is 8MPa, and the temperature of the secondary separator is 41 ℃.
Further, the preparation method of the vitamin C comprises the following steps:
(1) esterifying sodium gulonate or gulonate to obtain esterified liquid, and separating out gulonate crystal without crystal water in a crystallization mode;
(2) adding a hydrochloric acid solution with the mass concentration of 39% into a gulonic acid ester crystal serving as a raw material at normal temperature, stirring, cooling a system to-5 ℃, introducing HCl gas into the system solution, heating to 56 ℃, and preserving heat until the reaction is terminated to obtain the vitamin C.
The invention has the advantages and positive effects that: the ginkgo essential oil prepared by the preparation method of the ginkgo essential oil has high quality, and the quality of the additive solution is greatly improved; meanwhile, the vitamin C prepared by the preparation method of the vitamin C has high purity, and the prevention effect of the additive solution is greatly improved.
Drawings
FIG. 1 is a flow chart of the preparation method of the additive solution for preventing bacterial diseases in digestive tracts of poultry.
FIG. 2 is a flow chart of the method for preparing ginkgo essential oil according to the present invention.
FIG. 3 is a flow chart of a method for preparing vitamin C according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The application of the principles of the present invention will now be further described with reference to the accompanying drawings.
The invention provides an additive solution for preventing poultry digestive tract bacterial diseases, which is prepared from the following raw materials in parts by weight:
1 part of ginkgo essential oil, 3 parts of sandalwood, 5 parts of saffron, 8 parts of wormwood, 10 parts of spanishneedles herb, 12 parts of garlic and 9 parts of vitamin C.
As shown in figure 1, the preparation method of the additive solution for preventing the bacterial diseases of the digestive tracts of the poultry comprises the following steps:
s101, drying sandalwood, saffron, wormwood, sticktight and garlic respectively according to the weight parts of the raw materials, then placing the dried raw materials into a pulverizer to be pulverized, then decocting the pulverized raw materials with purified water, and filtering the decoction to obtain a mixed solution;
and S102, cooling the obtained mixed solution to normal temperature, adding the ginkgo essential oil and the vitamins in parts by weight of the raw materials, and uniformly mixing to obtain a finished product of the additive solution.
The decoction conditions provided by the invention are 2.5h of decoction and 31min of heat preservation.
As shown in fig. 2, the preparation method of the ginkgo essential oil provided by the invention comprises the following steps:
s201, picking fresh ginkgo leaves and ginkgo fruits, cleaning, sterilizing and drying the ginkgo leaves and the ginkgo fruits; uniformly mixing dried ginkgo leaves and ginkgo fruits in a weight ratio of 1:1, crushing, sieving with a 51-mesh sieve, and placing in an extraction kettle;
s202, inputting supercritical carbon dioxide fluid into an extraction kettle, and extracting under the condition that the flow rate of carbon dioxide is 61 kg/h;
s203, introducing the extracted carbon dioxide fluid into a first-stage separator and a second-stage separator in sequence for separation, wherein the flow rate of the carbon dioxide is 31 kg/h; removing the waxy component from the primary separator; and discharging the ginkgo oil from the secondary separator, heating for demulsification, and separating a water phase to obtain the ginkgo essential oil.
The extraction pressure provided by the invention is 36 MPa.
The extraction temperature provided by the invention is 51 ℃.
The extraction time provided by the invention is 9 h.
The pressure of the primary separator provided by the invention is 7MPa, and the temperature of the primary separator is 16 ℃.
The pressure of the secondary separator provided by the invention is 8MPa, and the temperature of the secondary separator is 41 ℃.
As shown in fig. 3, the preparation method of vitamin C provided by the present invention comprises:
s301, esterifying sodium gulonate or gulonate to prepare esterified liquid, and separating out gulonate crystals without crystal water in a crystallization mode;
s302, adding a hydrochloric acid solution with the mass concentration of 39% into a gulonic acid ester crystal serving as a raw material at normal temperature, stirring, cooling a system to-5 ℃, introducing HCl gas into the system solution, heating to 56 ℃, and preserving heat until the reaction is terminated to obtain the vitamin C.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. The additive solution for preventing the bacterial diseases of the digestive tracts of the poultry is characterized by being prepared from the following raw materials in parts by weight:
1 part of ginkgo essential oil, 3 parts of sandalwood, 5 parts of saffron, 8 parts of wormwood, 10 parts of spanishneedles herb, 12 parts of garlic and 9 parts of vitamin C.
2. The preparation method of the additive solution for preventing the bacterial diseases of the digestive tracts of the poultry according to claim 1, wherein the preparation method of the additive solution for preventing the bacterial diseases of the digestive tracts of the poultry comprises the following steps:
firstly, respectively drying sandalwood, saffron, wormwood, sticktight and garlic according to the weight parts of raw materials, then placing the dried raw materials into a pulverizer to be pulverized, then decocting the pulverized raw materials with purified water, and filtering the decoction to obtain a mixed solution;
and step two, after the obtained mixed solution is cooled to normal temperature, adding the ginkgo essential oil and the vitamins in parts by weight of the raw materials, and uniformly mixing to obtain a finished product of the additive solution.
3. The additive solution for preventing bacterial diseases of digestive tracts of birds as claimed in claim 2, wherein said decoction condition is decoction for 2.5h and heat preservation for 31 min.
4. The additive solution for preventing bacterial diseases of digestive tracts of birds as claimed in claim 1, wherein said ginkgo biloba essential oil is prepared by the following method:
1) picking fresh folium Ginkgo and semen Ginkgo, cleaning, sterilizing, and oven drying; uniformly mixing dried ginkgo leaves and ginkgo fruits in a weight ratio of 1:1, crushing, sieving with a 51-mesh sieve, and placing in an extraction kettle;
2) inputting supercritical carbon dioxide fluid into the extraction kettle, and extracting under the condition that the flow rate of carbon dioxide is 61 kg/h;
3) introducing the extracted carbon dioxide fluid into a first-stage separator and a second-stage separator in sequence for separation, wherein the flow rate of the carbon dioxide is 31 kg/h; removing the waxy component from the primary separator; and discharging the ginkgo oil from the secondary separator, heating for demulsification, and separating a water phase to obtain the ginkgo essential oil.
5. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 4, wherein said extraction pressure is 36 MPa.
6. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 4, wherein said extraction temperature is 51 ℃.
7. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 4, wherein said extraction time is 9 h.
8. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 4, wherein said first separator pressure is 7MPa and said first separator temperature is 16 ℃.
9. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 4, wherein said secondary separator pressure is 8MPa and said secondary separator temperature is 41 ℃.
10. The additive solution for preventing bacterial diseases of digestive tracts of birds according to claim 1, wherein the preparation method of vitamin C comprises the following steps:
(1) esterifying sodium gulonate or gulonate to obtain esterified liquid, and separating out gulonate crystal without crystal water in a crystallization mode;
(2) adding a hydrochloric acid solution with the mass concentration of 39% into a gulonic acid ester crystal serving as a raw material at normal temperature, stirring, cooling a system to-5 ℃, introducing HCl gas into the system solution, heating to 56 ℃, and preserving heat until the reaction is terminated to obtain the vitamin C.
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| CN202210364164.7A CN114712451A (en) | 2022-04-08 | 2022-04-08 | Additive solution for preventing poultry digestive tract bacterial diseases and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687035A (en) * | 2016-02-04 | 2016-06-22 | 江苏佰康生物科技股份有限公司 | Compound ginkgo essential oil with effects of resisting oxidation and delaying skin aging |
| CN107233475A (en) * | 2017-08-08 | 2017-10-10 | 黔东南苗族侗族自治州农业科学院 | A kind of Chinese medicine composition, its preparation method and application for preventing and treating birds alimentary canal bacteriosis |
| CN113045521A (en) * | 2021-03-23 | 2021-06-29 | 李淳明 | Preparation method of vitamin C |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687035A (en) * | 2016-02-04 | 2016-06-22 | 江苏佰康生物科技股份有限公司 | Compound ginkgo essential oil with effects of resisting oxidation and delaying skin aging |
| CN107233475A (en) * | 2017-08-08 | 2017-10-10 | 黔东南苗族侗族自治州农业科学院 | A kind of Chinese medicine composition, its preparation method and application for preventing and treating birds alimentary canal bacteriosis |
| CN113045521A (en) * | 2021-03-23 | 2021-06-29 | 李淳明 | Preparation method of vitamin C |
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Application publication date: 20220708 |