CN114710958A - 工程化的调节t细胞的产生 - Google Patents

工程化的调节t细胞的产生 Download PDF

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CN114710958A
CN114710958A CN202080077842.0A CN202080077842A CN114710958A CN 114710958 A CN114710958 A CN 114710958A CN 202080077842 A CN202080077842 A CN 202080077842A CN 114710958 A CN114710958 A CN 114710958A
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cell
cells
gene
sequence
transgene
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A.康维
H.方
G.邝
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Sangamo Therapeutics Inc
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Sangamo Therapeutics Inc
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CN202080077842.0A 2019-11-08 2020-11-09 工程化的调节t细胞的产生 Pending CN114710958A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962933252P 2019-11-08 2019-11-08
US62/933,252 2019-11-08
PCT/US2020/059730 WO2021092581A1 (en) 2019-11-08 2020-11-09 Generation of engineered regulatory t cells

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CN114710958A true CN114710958A (zh) 2022-07-05

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US (1) US20220380727A1 (enExample)
EP (1) EP4055039A1 (enExample)
JP (1) JP2023501388A (enExample)
KR (1) KR20220095223A (enExample)
CN (1) CN114710958A (enExample)
AU (1) AU2020378228A1 (enExample)
CA (1) CA3160113A1 (enExample)
IL (1) IL292676A (enExample)
WO (1) WO2021092581A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4237542A1 (en) * 2020-10-28 2023-09-06 Sangamo Therapeutics, Inc. Generation of cd4+ effector and regulatory t cells from human pluripotent stem cells
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
WO2022165419A1 (en) 2021-02-01 2022-08-04 Kyverna Therapeutics, Inc. Methods for increasing t-cell function
EP4410965A4 (en) 2021-09-27 2025-09-24 Univ Kyoto T LYMPHOCYTE PRODUCTION PROCESS
EP4493697A4 (en) * 2022-03-16 2026-06-10 Univ Minnesota GENETICALLY MODIFIED T LYMPHOCYTES FOR CELL THERAPY
EP4497822A4 (en) 2022-03-23 2026-03-18 Univ Kyoto PROCESS FOR THE PRODUCTION OF REGULATORY T LYMPHOCYTES
CN120112629A (zh) 2022-09-26 2025-06-06 国立大学法人京都大学 T细胞产生方法
US20250270583A1 (en) * 2022-10-26 2025-08-28 Biodrive, Inc. Methods for Suppression of Gene Silencing in Plants
EP4642901A2 (en) * 2022-12-30 2025-11-05 Bluerock Therapeutics LP Engineered cells for the production of cd4+ t cells and cd4+ tregs
GB202312699D0 (en) * 2023-08-18 2023-10-04 Cambridge Entpr Ltd Controllable expression in mammalian cells
WO2025223995A1 (en) * 2024-04-26 2025-10-30 Tcbalance Biopharmaceuticals Gmbh Gene-modified t regulatory cell
WO2026110966A1 (ko) * 2024-11-21 2026-05-28 연세대학교 산학협력단 키메라 항원 수용체를 포함하는 범용성 면역조절 t세포 및 이의 용도

Citations (2)

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WO2017062035A1 (en) * 2015-10-09 2017-04-13 Abt Holding Company Methods for enhancing proliferation of t regulatory cells
CN110139675A (zh) * 2016-10-31 2019-08-16 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4 t细胞治疗自身免疫疾病的方法

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EP3789487A1 (en) * 2013-04-03 2021-03-10 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
FR3079239A1 (fr) * 2018-03-23 2019-09-27 Centre National De La Recherche Scientifique Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations
JP7575949B2 (ja) * 2018-04-27 2024-10-31 シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現
SG11202007878UA (en) 2018-04-27 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Expression of foxp3 in edited cd34+ cells

Patent Citations (2)

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WO2017062035A1 (en) * 2015-10-09 2017-04-13 Abt Holding Company Methods for enhancing proliferation of t regulatory cells
CN110139675A (zh) * 2016-10-31 2019-08-16 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4 t细胞治疗自身免疫疾病的方法

Non-Patent Citations (2)

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Title
JUSTIN EYQUEM ET AL.,: "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection", 《NATURE》, vol. 543, 22 February 2017 (2017-02-22), pages 113 - 117 *
RIZWANUL HAQUE ET AL.,: "Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity", 《J IMMUNOL》, vol. 189, no. 3, 25 June 2012 (2012-06-25), pages 1228 - 1236, XP055377907, DOI: 10.4049/jimmunol.1200633 *

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IL292676A (en) 2022-07-01
CA3160113A1 (en) 2021-05-14
JP2023501388A (ja) 2023-01-18
AU2020378228A1 (en) 2022-05-26
WO2021092581A9 (en) 2022-06-23
KR20220095223A (ko) 2022-07-06
WO2021092581A1 (en) 2021-05-14
US20220380727A1 (en) 2022-12-01
EP4055039A1 (en) 2022-09-14

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