CN114699632B - Drug balloon for cerebral blood vessels and preparation method thereof - Google Patents

Drug balloon for cerebral blood vessels and preparation method thereof Download PDF

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Publication number
CN114699632B
CN114699632B CN202210325132.6A CN202210325132A CN114699632B CN 114699632 B CN114699632 B CN 114699632B CN 202210325132 A CN202210325132 A CN 202210325132A CN 114699632 B CN114699632 B CN 114699632B
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China
Prior art keywords
medicine
balloon
frame
sacculus
move
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CN202210325132.6A
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Chinese (zh)
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CN114699632A (en
Inventor
方晟东
黄佩佩
郑从胜
涂真金
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Huizhou Shunmei Medical Technology Co ltd
Shenzhen Shunmei Medical Co ltd
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Shenzhen Shunmei Medical Co ltd
Huizhou Shunmei Medical Technology Co ltd
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Priority to CN202210325132.6A priority Critical patent/CN114699632B/en
Publication of CN114699632A publication Critical patent/CN114699632A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1027Making of balloon catheters
    • A61M25/1029Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M25/0045Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/104Balloon catheters used for angioplasty
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1027Making of balloon catheters
    • A61M25/1029Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A61M2025/1031Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/105Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M2025/1043Balloon catheters with special features or adapted for special applications
    • A61M2025/1086Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0693Brain, cerebrum

Abstract

The invention discloses a drug balloon for cerebral vessels and a preparation method thereof, belonging to the technical field of medical instruments and comprising a workbench, a forming device, a drug feeding device, a positioning and rotating device and two mechanical grippers, wherein the workbench is placed on a horizontal plane, the forming device is arranged at the top of the workbench, the drug feeding device is arranged at the top of the workbench and is positioned beside the forming device, the two mechanical grippers are arranged at the top of the workbench and are respectively positioned beside the forming device and the drug feeding device, and the positioning and rotating device is arranged at the top of the workbench and is positioned beside the drug feeding device. The polyethylene plastic material in the forming device is processed into the medicine balloon with a plurality of groups of concave structures through the forming device, and then the medicine balloon after forming is subjected to medicine feeding operation through the medicine feeding device matched with the positioning and rotating device, so that the preparation operation of the medicine balloon is completed, the medicine carrying amount of the medicine balloon is higher, the follow-up treatment effect of the medicine balloon on the cardiovascular system is improved, and the preparation is completed.

Description

Drug balloon for cerebral blood vessels and preparation method thereof
Technical Field
The invention relates to the technical field of medical instruments, in particular to a drug balloon for a cerebral blood vessel and a preparation method thereof.
Background
In recent years, a new technology of preventing restenosis of blood vessels after interventional therapy, namely a drug balloon, appears. The method is a technology that drugs for resisting vascular intimal hyperplasia are coated on the surface of a balloon, when the balloon reaches a diseased vascular wall and is stretched and inflated, the balloon is in contact with the intimal of the vascular wall, and the drugs are pressurized, rapidly released and transferred into the local vascular wall. The medicine has local effect of resisting intimal hyperplasia of blood vessel, thereby preventing restenosis after vascular intervention. The research in the aspect of clinical application shows that the medicine balloon shows good curative effect when used for treating ISR lesion, and can be used for treating small vessel lesion, bifurcation lesion, primary lesion of partial tubular artery vessel and patients who cannot tolerate or are not suitable for long-term oral administration of the duplex antiplatelet medicine.
However, the existing processing of the drug balloon can not increase the drug carrying capacity of the drug balloon, so that the drug balloon has low drug consumption when treating the cardiovascular disease, and the cardiovascular treatment work is influenced.
Disclosure of Invention
The embodiment of the invention provides a drug balloon for a cerebral blood vessel and a preparation method thereof, which aim to solve the technical problems.
The embodiment of the invention adopts the following technical scheme: the utility model provides a medicine sacculus for cerebral blood vessel, includes medicine sacculus and sets up a plurality of sunk structure on the medicine sacculus, sunk structure is equipped with a plurality ofly, and is a plurality of sunk structure equidistant setting is on the medicine sacculus, the medicine sacculus is made through the polyethylene plastics material.
A preparation method of a drug balloon for cerebral vessels comprises the following preparation method steps:
the method comprises the following steps that firstly, a workbench, a forming device, a medicine feeding device, a positioning rotating device and two mechanical clamping hands are arranged, when a manipulator puts polyethylene materials into a mold space, a driving electric cylinder drives a driving block to move in a placement box, two limiting blocks can limit the moving position of the driving block, when the driving electric cylinder drives the driving block to move, two groups of forming assemblies can be driven to draw the polyethylene materials in the mold space, and therefore the polyethylene materials are processed, the two groups of forming assemblies can be driven to process the polyethylene materials at the same time through the movement of the driving block, the working efficiency of processing the medicine balloons is improved, and meanwhile, the processing and preparation of the two groups of medicine balloons are completed;
secondly, when the driving electric cylinder drives the driving block to move, the driving block moves to drive the two sliding blocks to move, the two sliding blocks move to drive the die frame to move through the sliding grooves, so that the die frame is close to the inner wall of the placing box, the polyethylene material is extruded, then the polyethylene material is heated through the heating plate, the forming work of the medicine balloon is completed, the die frame and the plurality of bulges on the inner wall of the placing box enable the medicine balloon to be provided with a plurality of concave structures, and therefore the medicine balloon can be matched with a medicine feeding device to be provided with more medicines, and the effect of the medicine balloon on the treatment of cardiovascular diseases is better;
thirdly, after the medicine balloon is preliminarily prepared and molded by the molding device, the medicine balloon is placed on the positioning rotating device through a mechanical gripper, then the electric sliding table drives the bearing seat to move, the bearing seat moves to drive the injection medicine applying device to move so as to apply medicine to the surface of the medicine balloon, so that the surface and the concave structure of the medicine balloon are fully filled with medicine, and the medicine applying operation to the medicine balloon is completed;
fourthly, after the medicine feeding assembly carries out medicine feeding operation on the medicine balloon, the working electric cylinder drives the lifting frame to move, when the working electric cylinder moves, the blocking frame limits the medicine balloon, the lifting frame moves so that the trimming compression roller is in contact with the surface of the medicine balloon full of medicines, then the electric sliding table drives the bearing seat to move so that the trimming compression roller moves on the surface of the medicine balloon, the medicines in the concave structure are compacted into the concave structure of the medicine balloon, the medicine scattering phenomenon is prevented when the medicine balloon moves and is conveyed in a blood vessel, the scraper can scrape the medicines attached to the trimming compression roller, the redundant medicines fall into the material receiving box, the redundant medicines can be collected and processed, and the work is finished;
fifthly, after the medicine sacculus was tentatively prepared by forming device, place the wire of medicine sacculus on fixed orifices and rotatory tong through mechanical tong, the briquetting removed on the positioning seat under the piezoelectricity jar can drive this moment, carries on spacingly to the medicine sacculus, thereby the rotating electrical machines can drive rotatory tong and remove the medicine sacculus rotation afterwards, and the device of adding medicine in the cooperation can carry out effectual comprehensive medicine loading work to the surface of medicine sacculus, accomplishes the preparation.
Further, the workstation is placed on the horizontal plane, forming device sets up the top at the workstation, the device of adding medicine to set up at the top of workstation and is located forming device's side, two mechanical tong sets up at the top of workstation and is located forming device and the side of adding medicine to the device respectively, the setting of location rotary device is at the top of workstation and is located the side of the device of adding medicine to.
Further, forming device includes drive assembly and shaping subassembly, drive assembly sets up the top at the workstation, shaping subassembly set up on drive assembly and with drive assembly sliding fit, drive assembly is including placing box, driving electric jar, limit baffle, drive block, spring and two stoppers, place the box and place the top at the workstation, limit baffle is fixed to be set up in placing the box, the fixed setting of driving electric jar is in placing the box and the flexible end and the limit baffle sliding fit of driving electric jar, the drive block sets up the flexible serving and with placing box sliding fit of driving electric jar, the inside of drive block is equipped with the recess, the both ends of spring are connected with the recess in the drive block respectively and the inner wall of placing the box, two the stopper symmetry is fixed to be set up in placing the box, the drive block is equipped with the recess corresponding with two stoppers.
Further, the shaping subassembly is equipped with two sets ofly, two sets of the shaping subassembly symmetry slides and sets up in placing the box, and is two sets of the shaping subassembly all includes mould frame and hot plate the mould frame slides and sets up in placing the box, be equipped with the spout on the mould frame, be equipped with on the drive block with mould frame upper chute sliding fit's slider, the mould frame forms the mould space with the inner wall of placing the box, the mould space is circularly, the mould space that the mould frame formed with the inner wall of placing the box is equipped with the arch that the multiunit equidistant set up, the hot plate is fixed to be set up on limit baffle and is located the side in mould space.
Further, the device of adding medicine includes the subassembly of adding medicine and repaiies the subassembly, the subassembly of adding medicine sets up at the top of workstation and is located the side of placing the box, it sets up on the subassembly of adding medicine and with the subassembly sliding fit of adding medicine, the subassembly of adding medicine includes electronic slip table, bears the seat, sprays the ware of adding medicine and receives the workbin, the fixed top that sets up at the workstation of electronic slip table, bear the seat set up on electronic slip table and with electronic slip table sliding fit, spray the fixed setting of the ware of adding medicine and bear the seat, receive the workbin and place at the top of workstation and be located the below of spraying the ware of adding medicine.
Further, the trimming component comprises a working electric cylinder, a blocking frame, a lifting frame, a trimming compression roller and a scraping plate, wherein the working electric cylinder is rotatably arranged on the bearing seat, the blocking frame is fixedly arranged on the bearing seat, the lifting frame is rotatably arranged on the bearing seat, the telescopic end of the working electric cylinder is in hinged fit with the lifting frame, the trimming compression roller is rotatably arranged on the lifting frame, and the scraping plate is fixedly arranged on the lifting frame and positioned beside the trimming compression roller.
Further, the positioning and rotating device comprises a supporting plate, a rotating motor, a rotating clamp, a positioning seat, a lower piezoelectric cylinder and a lower pressing block, wherein the supporting plate and the positioning seat are arranged at the top of the workbench, the supporting plate and the positioning seat are respectively positioned on two sides of the material receiving box, the rotating motor is arranged on the supporting plate, a main shaft of the rotating motor is in running fit with the supporting plate, the rotating clamp is arranged on the main shaft of the rotating motor and is in running fit with the main shaft of the rotating motor, the lower piezoelectric cylinder is fixedly arranged on the positioning seat, the lower pressing block is arranged on the telescopic end of the lower piezoelectric cylinder, a moving groove is formed in the positioning seat, the lower pressing block is in sliding fit with the moving groove in the positioning seat, and a fixing hole is formed between the lower pressing block and the positioning seat.
The embodiment of the invention adopts at least one technical scheme which can achieve the following beneficial effects:
one of the two methods is that when the medicine sacculus is prepared, the polyethylene plastic material in the forming device is processed into the medicine sacculus with a plurality of groups of concave structures through the forming device, then the medicine sacculus after forming is subjected to medicine feeding operation through the medicine feeding device matched positioning rotating device, the preparation operation of the medicine sacculus is completed, the medicine carrying amount of the medicine sacculus is higher, the follow-up treatment effect of the medicine sacculus on the cardiovascular is improved, the preparation is completed, the medicine sacculus can be moved and conveyed through the two mechanical arms, the working efficiency of the processing and the preparation is improved, and the work is completed.
Two, when the manipulator put into the mould space with the polyethylene material in, the driving electricity jar drives the drive block and is placing the box internal movement, two stoppers can carry on spacingly to the shift position of drive block, when the driving electricity jar drives the drive block and removes, then can drive two sets of shaping subassemblies and draw close to the polyethylene material of locating in the mould space, thereby carry out processing to the polyethylene material, can drive two sets of shaping subassemblies simultaneously through the drive block removal and process the polyethylene material, the work efficiency to medicine sacculus processing has been improved, accomplish simultaneously and prepare two sets of medicine sacculus processing.
Third, when the driving electric cylinder drives the drive block and removes, the drive block removes and drives two slider removals, thereby two slider removals drive the mould frame through the spout and remove, make the mould frame draw close to placing the box inner wall, thereby extrude the polyethylene material, later heat through the hot plate, accomplish the shaping work to the medicine sacculus, mould frame and a plurality of arch of placing on the box inner wall, be equipped with a plurality of sunk structure on making the medicine sacculus, thereby make the cooperation of medicine sacculus device of adding medicine can be equipped with more medicines, make the medicine sacculus treat the effect better to the cardiovascular.
Fourthly, after the medicine sacculus was tentatively prepared the shaping by forming device, place the medicine sacculus on location rotary device through mechanical tong, electronic slip table drives afterwards and bears the seat and remove, thereby bears the seat and removes and drive and spray the medicine ware removal and carry out the medicine processing of scribbling to the surface of medicine sacculus, thereby is covered with the medicine in the surface of medicine sacculus and the sunk structure, accomplishes the operation of adding medicine to the medicine sacculus.
Fifthly, after the subassembly of adding medicine to the medicine sacculus operation of adding medicine, the electric jar of work drives the hoisting frame and removes, when the electric jar of work removes, keep off the frame and carry on spacingly to it, thereby the hoisting frame removes and makes the compression roller of repairing contact with the medicine sacculus surface of being covered with the medicine, thereby later drive through electronic slip table and bear the seat and remove and make the compression roller of repairing remove on the surface of medicine sacculus, make the medicine compaction in the sunk structure to the sunk structure of medicine sacculus, when preventing that the medicine sacculus from removing in the blood vessel and carrying, the phenomenon that the medicine scatters appears, the scraper blade then can strike off the medicine of pasting on repairing the compression roller, make unnecessary medicine fall into can collect the processing to unnecessary medicine in receiving the workbin, accomplish work.
Sixth, after the medicine sacculus was tentatively prepared by forming device, place the wire of medicine sacculus on fixed orifices and rotatory tong through mechanical tong, the briquetting removed on the positioning seat under the piezoelectric cylinder can drive this moment, spacing to the medicine sacculus, thereby the rotating electrical machines can drive rotatory tong and remove the medicine sacculus rotation afterwards, and the device of adding medicine in the cooperation can carry out effectual comprehensive medicine of adding to the surface of medicine sacculus, accomplishes the preparation.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic perspective view of a molding apparatus according to the present invention;
FIG. 3 is a partial perspective view of a molding apparatus according to the present invention;
FIG. 4 is a schematic partial perspective view of a molding apparatus according to the present invention;
FIG. 5 is a schematic view of a partial three-dimensional structure of the molding apparatus of the present invention;
FIG. 6 is a first perspective view of a part of the loading device of the present invention;
FIG. 7 is a schematic view of a partial three-dimensional structure of a feeding device according to the present invention;
FIG. 8 is a partial perspective view of the present invention;
fig. 9 is a schematic perspective view of the drug balloon according to the present invention.
Reference numerals
The medicine balloon 1, the concave structure 2, the workbench 3, the forming device 4, the driving assembly 5, the placing box 51, the driving electric cylinder 52, the limit baffle 53, the driving block 54, the spring 55, the limit block 56, the forming assembly 6, the mold frame 61, the chute 611, the heating plate 62, the mold space 63, the protrusion 64, the medicine feeding device 7, the medicine feeding assembly 8, the electric sliding table 81, the bearing seat 82, the spraying medicine feeding device 83, the material receiving box 84, the finishing assembly 9, the working electric cylinder 91, the baffle frame 92, the lifting frame 93, the finishing press roller 94, the scraper 95, the positioning rotating device 10, the supporting plate 101, the rotating motor 102, the rotating gripper 103, the positioning seat 104, the lower pressing electric cylinder 105, the lower pressing block 106 and the mechanical gripper 11.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the accompanying drawings. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The technical solutions provided by the embodiments of the present invention are described in detail below with reference to the accompanying drawings.
Referring to fig. 1 to 9, an embodiment of the present invention provides a drug balloon for a cerebral blood vessel, including a drug balloon 1 and a plurality of concave structures 2 arranged on the drug balloon 1, where the plurality of concave structures 2 are arranged, the plurality of concave structures 2 are arranged on the drug balloon 1 at equal intervals, and the drug balloon 1 is made of a polyethylene plastic material.
A preparation method of a drug balloon for cerebral vessels comprises the following preparation method steps:
firstly, a workbench 3, a forming device 4, a medicine feeding device 7, a positioning rotating device 10 and two mechanical grippers 11 are arranged, when a manipulator puts polyethylene materials into a mold space 63, a driving electric cylinder 52 drives a driving block 54 to move in a placing box 51, two limiting blocks 56 can limit the moving position of the driving block 54, when the driving electric cylinder 52 drives the driving block 54 to move, two groups of forming assemblies 6 can be driven to draw the polyethylene materials in the mold space 63 together, so that the polyethylene materials are processed, the two groups of forming assemblies 6 can be driven to process the polyethylene materials simultaneously by the movement of the driving block 54, the working efficiency of processing the medicine balloon 1 is improved, and the processing and preparation of the two groups of medicine balloons 1 are completed simultaneously;
secondly, when the driving electric cylinder 52 drives the driving block 54 to move, the driving block 54 moves to drive the two sliding blocks to move, the two sliding blocks move to drive the mold frame 61 to move through the sliding groove 611, so that the mold frame 61 is close to the inner wall of the placing box 51, the polyethylene material is extruded, then the polyethylene material is heated through the heating plate 62, the forming work of the drug balloon 1 is completed, the mold frame 61 and the plurality of bulges 64 on the inner wall of the placing box 51 are provided with the plurality of concave structures 2, so that the drug balloon 1 can be assembled with more drugs in cooperation with the drug feeding device 7, and the effect of the drug balloon 1 on the treatment of cardiovascular diseases is better;
thirdly, after the medicine balloon 1 is preliminarily prepared and molded by the molding device 4, the medicine balloon 1 is placed on the positioning and rotating device 10 through the mechanical clamping hand 11, then the electric sliding table 81 drives the bearing seat 82 to move, the bearing seat 82 moves to drive the injection medicine-feeding device 83 to move so as to perform medicine coating treatment on the surface of the medicine balloon 1, so that the surface of the medicine balloon 1 and the concave structure 2 are fully filled with medicines, and the medicine feeding operation on the medicine balloon 1 is completed;
fourthly, after the medicine feeding assembly 8 carries out medicine feeding operation on the medicine balloon 1, the working electric cylinder 91 drives the lifting frame 93 to move, when the working electric cylinder 91 moves, the blocking frame 92 limits the working electric cylinder 91, the lifting frame 93 moves so that the trimming pressure roller 94 is in contact with the surface of the medicine balloon 1 full of medicine, then the electric sliding table 81 drives the bearing seat 82 to move so that the trimming pressure roller 94 moves on the surface of the medicine balloon 1, the medicine in the concave structure 2 is compacted into the concave structure 2 of the medicine balloon 1, the phenomenon that the medicine scatters when the medicine balloon 1 moves and is conveyed in a blood vessel is prevented, the scraper 95 can scrape the medicine attached to the trimming pressure roller 94, and the redundant medicine is collected and dropped into the box 84 so as to collect and process the redundant medicine and complete the work;
fifthly, after medicine sacculus 1 is tentatively prepared by forming device 4, place medicine sacculus 1's wire on fixed orifices and rotatory tong 103 through machinery tong 11, it removes on positioning seat 104 to push down briquetting 106 can drive this moment, it is spacing to carry out medicine sacculus 1, thereby rotating electrical machines 102 can drive rotatory tong 103 and remove messenger medicine sacculus 1 rotatory afterwards, medicine device 7 can carry out effectual comprehensive medicine loading work to medicine sacculus 1's surface in the cooperation, the completion preparation.
Preferably, the workbench 3 is placed on a horizontal plane, the forming device 4 is arranged at the top of the workbench 3, the medicine feeding device 7 is arranged at the top of the workbench 3 and located beside the forming device 4, the two mechanical grippers 11 are arranged at the top of the workbench 3 and located beside the forming device 4 and the medicine feeding device 7 respectively, and the positioning and rotating device 10 is arranged at the top of the workbench 3 and located beside the medicine feeding device 7; when carrying out the preparation to medicine sacculus 1, the polyethylene plastics material that will be in forming device 4 through forming device 4 is processed into medicine sacculus 1 that is equipped with multiunit sunk structure 2, later through the operation of adding medicine 7 cooperation location rotary device 10 to the medicine sacculus 1 after the shaping carry out the operation of adding medicine, accomplish the preparation operation of medicine sacculus 1, it is higher to make medicine sacculus 1 drug loading capacity, thereby improve the follow-up treatment effect to the cardiovascular of medicine sacculus 1, accomplish the preparation, can remove the transport to medicine sacculus 1 through two manipulators, the work efficiency of processing preparation has been improved, accomplish work.
Preferably, the forming device 4 includes a driving assembly 5 and a forming assembly 6, the driving assembly 5 is disposed at the top of the workbench 3, the forming assembly 6 is disposed on the driving assembly 5 and is in sliding fit with the driving assembly 5, the driving assembly 5 includes a placing box 51, an electric driving cylinder 52, a limit baffle 53, a driving block 54, a spring 55 and two limit blocks 56, the placing box 51 is disposed at the top of the workbench 3, the limit baffle 53 is fixedly disposed in the placing box 51, the electric driving cylinder 52 is fixedly disposed in the placing box 51 and the telescopic end of the electric driving cylinder 52 is in sliding fit with the limit baffle 53, the driving block 54 is disposed on the telescopic end of the electric driving cylinder 52 and is in sliding fit with the placing box 51, a groove is disposed inside the driving block 54, two ends of the spring 55 are respectively connected with the groove in the driving block 54 and the inner wall of the placing box 51, the two limit blocks 56 are symmetrically and fixedly disposed in the placing box 51, and the driving block 54 is provided with grooves corresponding to the two limit blocks 56; when the manipulator puts into the mould space 63 with the polyethylene material in, the driving electric cylinder 52 drives the drive block 54 and removes in placing box 51, two stopper 56 can carry on spacingly to the shift position of drive block 54, when the driving electric cylinder 52 drives the drive block 54 and removes, then can drive two sets of forming component 6 and draw close to the polyethylene material that is in mould space 63, thereby carry out processing to the polyethylene material, can drive two sets of forming component 6 simultaneously through the drive block 54 and process the polyethylene material, the work efficiency to medicine sacculus 1 processing has been improved, accomplish simultaneously and prepare two sets of medicine sacculus 1 processing.
Preferably, two sets of the forming assemblies 6 are arranged, the two sets of the forming assemblies 6 are symmetrically arranged in the placing box 51 in a sliding manner, each set of the forming assemblies 6 comprises a mold frame 61 and a heating plate 62, the mold frame 61 is arranged in the placing box 51 in a sliding manner, a sliding groove 611 is arranged on the mold frame 61, a sliding block in sliding fit with the sliding groove 611 on the mold frame 61 is arranged on the driving block 54, a mold space 63 is formed by the mold frame 61 and the inner wall of the placing box 51, the mold space 63 is circular, a plurality of sets of protrusions 64 arranged at equal intervals are arranged in the mold space 63 formed by the mold frame 61 and the inner wall of the placing box 51, and the heating plate 62 is fixedly arranged on the limiting baffle 53 and positioned beside the mold space 63; when the driving electric cylinder 52 drives the driving block 54 to move, the driving block 54 moves to drive two sliders to move, thereby two sliders move and drive the mould frame 61 to move through the spout 611, make the mould frame 61 to placing the box 51 inner wall and drawing close, thereby extrude the polyethylene material, later heat through the hot plate 62, the completion is to the shaping work of medicine sacculus 1, mould frame 61 with place a plurality of arch 64 on the box 51 inner wall, be equipped with a plurality of sunk structure 2 on the medicine sacculus 1, thereby make the medicine sacculus 1 cooperate and go up medicine device 7 and can be equipped with more medicines, make the medicine sacculus 1 treat the effect better to cardiovascular.
Preferably, the medicine feeding device 7 comprises a medicine feeding assembly 8 and a trimming assembly 9, the medicine feeding assembly 8 is arranged at the top of the workbench 3 and is located at the side of the placing box 51, the trimming assembly 9 is arranged on the medicine feeding assembly 8 and is in sliding fit with the medicine feeding assembly 8, the medicine feeding assembly 8 comprises an electric sliding table 81, a bearing seat 82, a spraying medicine feeding device 83 and a material receiving box 84, the electric sliding table 81 is fixedly arranged at the top of the workbench 3, the bearing seat 82 is arranged on the electric sliding table 81 and is in sliding fit with the electric sliding table 81, the spraying medicine feeding device 83 is fixedly arranged on the bearing seat 82, and the material receiving box 84 is arranged at the top of the workbench 3 and is located below the spraying medicine feeding device 83; after the shaping is tentatively prepared by forming device 4 to medicine sacculus 1, place medicine sacculus 1 on location rotary device 10 through mechanical tong 11, electronic slip table 81 drives afterwards and bears seat 82 and remove, thereby bears seat 82 and removes to drive and spray medicine applying device 83 and remove and scribble the medicine to the surface of medicine sacculus 1 and handle, is full of the medicine in making medicine sacculus 1's surface and the sunk structure 2, accomplishes the operation of adding medicine to medicine sacculus 1.
Preferably, the dressing assembly 9 includes an electric operating cylinder 91, a blocking frame 92, a lifting frame 93, a dressing pressure roller 94 and a scraper 95, the electric operating cylinder 91 is rotatably disposed on the bearing seat 82, the blocking frame 92 is fixedly disposed on the bearing seat 82, the lifting frame 93 is rotatably disposed on the bearing seat 82, a telescopic end of the electric operating cylinder 91 is in hinged fit with the lifting frame 93, the dressing pressure roller 94 is rotatably disposed on the lifting frame 93, and the scraper 95 is fixedly disposed on the lifting frame 93 and beside the dressing pressure roller 94; after the subassembly 8 of adding medicine to medicine sacculus 1 carries out the operation of adding medicine to, work electric cylinder 91 drives hoisting frame 93 and removes, when work electric cylinder 91 removes, it is spacing to it to keep off frame 92, thereby hoisting frame 93 removes to make and repaiies compression roller 94 and the medicine sacculus 1 surface contact that is covered with the medicine, thereby later drive through electronic slip table 81 and bear seat 82 and remove to make and repair compression roller 94 and remove on the surface of medicine sacculus 1, make the medicine compaction in the sunk structure 2 to the sunk structure 2 of medicine sacculus 1, when preventing that medicine sacculus 1 from removing the transport in the blood vessel, the phenomenon that the medicine scatters appears, scraper blade 95 then can strike off the medicine of pasting on repairing compression roller 94, make unnecessary medicine fall into to receive in the material case 84 can collect the processing to unnecessary medicine, accomplish work.
Preferably, the positioning and rotating device 10 includes a support plate 101, a rotating electrical machine 102, a rotating gripper 103, a positioning seat 104, a lower piezoelectric cylinder 105 and a lower pressing block 106, the support plate 101 and the positioning seat 104 are both disposed at the top of the workbench 3, the support plate 101 and the positioning seat 104 are respectively located at two sides of the material receiving box 84, the rotating electrical machine 102 is disposed on the support plate 101, a spindle of the rotating electrical machine 102 is rotatably fitted with the support plate 101, the rotating gripper 103 is disposed on the spindle of the rotating electrical machine 102 and is in transmission fit with the spindle of the rotating electrical machine 102, the lower piezoelectric cylinder 105 is fixedly disposed on the positioning seat 104, the lower pressing block 106 is disposed on a telescopic end of the lower piezoelectric cylinder 105, a moving groove is disposed on the positioning seat 104, the lower pressing block 106 is in sliding fit with the moving groove on the positioning seat 104, and a fixing hole is formed between the lower pressing block 106 and the positioning seat 104; after medicine sacculus 1 is tentatively prepared by forming device 4, place medicine sacculus 1's wire on fixed orifices and rotatory tong 103 through mechanical tong 11, briquetting 106 removes on positioning seat 104 under can driving by lower piezoelectric cylinder 105 this moment, it is spacing to carry out medicine sacculus 1, thereby rotating electrical machines 102 can drive rotatory tong 103 and remove and make medicine sacculus 1 rotatory on the fixed orifices afterwards, medicine device 7 can carry out effectual comprehensive medicine loading work to medicine sacculus 1's surface in the cooperation, accomplish the preparation.
The above description is only an example of the present invention, and is not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims (4)

1. The utility model provides a preparation method of medicine sacculus for cerebral blood vessel, medicine sacculus for cerebral blood vessel includes medicine sacculus (1) and sets up a plurality of sunk structure (2) on medicine sacculus (1), sunk structure (2) are equipped with a plurality ofly, a plurality of sunk structure (2) equidistant setting is on medicine sacculus (1), medicine sacculus (1) is made through polyethylene plastics material, its characterized in that: the preparation method comprises the following steps:
the method comprises the steps that firstly, a workbench (3), a forming device (4), a medicine feeding device (7), a positioning rotating device (10) and two mechanical clamping hands (11) are arranged, when a manipulator puts polyethylene materials into a mold space (63), a driving electric cylinder (52) drives a driving block (54) to move in a placement box (51), two limiting blocks (56) can limit the moving position of the driving block (54), and when the driving electric cylinder (52) drives the driving block (54) to move, two groups of forming assemblies (6) can be driven to approach the polyethylene materials in the mold space (63), so that the polyethylene materials are processed, the two groups of forming assemblies (6) can be driven to process the polyethylene materials at the same time through the movement of the driving block (54), the working efficiency of processing the medicine sacculus (1) is improved, and the processing and the two groups of medicine sacculus (1) are processed and prepared at the same time;
secondly, when the driving electric cylinder (52) drives the driving block (54) to move, the driving block (54) moves to drive the two sliding blocks to move, the two sliding blocks move to drive the die frame (61) to move through the sliding groove (611), so that the die frame (61) is close to the inner wall of the placing box (51), the polyethylene material is extruded, then the polyethylene material is heated through the heating plate (62), the forming work of the medicine balloon (1) is completed, the die frame (61) and the plurality of bulges (64) on the inner wall of the placing box (51) enable the medicine balloon (1) to be provided with the plurality of concave structures (2), and therefore the medicine balloon (1) can be matched with the medicine feeding device (7) to be provided with more medicines, and the effect of the medicine balloon (1) on the treatment of cardiovascular diseases is better;
thirdly, after the medicine balloon (1) is preliminarily prepared and molded by the molding device (4), the medicine balloon (1) is placed on the positioning rotating device (10) through a mechanical clamping hand (11), then the electric sliding table (81) drives the bearing seat (82) to move, the bearing seat (82) moves to drive the spraying medicine-feeding device (83) to move, so that medicine coating treatment is carried out on the surface of the medicine balloon (1), the surface of the medicine balloon (1) and the concave structure (2) are fully filled with medicines, and medicine feeding operation of the medicine balloon (1) is completed;
fourthly, after the medicine feeding operation is carried out on the medicine balloon (1) by the medicine feeding assembly (8), the working electric cylinder (91) drives the lifting frame (93) to move, when the working electric cylinder (91) moves, the blocking frame (92) limits the medicine balloon, the lifting frame (93) moves so that the trimming pressure roller (94) is in contact with the surface of the medicine balloon (1) full of medicine, then the electric sliding table (81) drives the bearing seat (82) to move so that the trimming pressure roller (94) moves on the surface of the medicine balloon (1), the medicine in the concave structure (2) is compacted into the concave structure (2) of the medicine balloon (1), the phenomenon that the medicine scatters when the medicine balloon (1) moves and is conveyed in a blood vessel is prevented, the scraper blade (95) can scrape the medicine adhered to the trimming pressure roller (94), and the redundant medicine can be collected and treated by falling into the material receiving box (84), so that the work is completed;
fifthly, after the medicine sacculus (1) is preliminarily prepared by the forming device (4), a lead of the medicine sacculus (1) is placed on a fixed hole and a rotary clamping hand (103) through a mechanical clamping hand (11), a pressing block (106) can be driven by a lower piezoelectric cylinder (105) to move on a positioning seat (104) at the moment, the medicine sacculus (1) is limited, then a rotary motor (102) can drive the rotary clamping hand (103) to move so that the medicine sacculus (1) rotates, the medicine feeding device (7) is matched to carry out effective comprehensive medicine feeding work on the surface of the medicine sacculus (1) to complete preparation, the workbench (3) is placed on a horizontal plane, the forming device (4) is arranged at the top of the workbench (3), the medicine feeding device (7) is arranged at the top of the workbench (3) and is positioned at the side of the forming device (4), two mechanical clamping hands (11) are arranged at the top of the workbench (3) and are respectively positioned at the top of the forming device (4) and the medicine feeding device (7), the medicine feeding device (10) is arranged at the top of the workbench (3) and comprises a medicine feeding component (8) and a medicine feeding device (7) which is arranged at the top of the workbench (8), the dressing assembly (9) is arranged on the medicine feeding assembly (8) and is in sliding fit with the medicine feeding assembly (8), the medicine feeding assembly (8) comprises an electric sliding table (81), a bearing seat (82), a medicine feeding device (83) and a material receiving box (84) which are sprayed, the electric sliding table (81) is fixedly arranged at the top of the workbench (3), the bearing seat (82) is arranged on the electric sliding table (81) and is in sliding fit with the electric sliding table (81), the medicine feeding device (83) is fixedly arranged on the bearing seat (82), the material receiving box (84) is arranged at the top of the workbench (3) and is positioned below the medicine feeding device (83) which is sprayed, the dressing assembly (9) comprises a working electric cylinder (91), a lifting frame (92), a dressing frame (93), a dressing compression roller (94) and a scraping plate (95), the working electric cylinder (91) is rotatably arranged on the bearing seat (82), the dressing frame (92) is fixedly arranged on the bearing seat (82), the lifting frame (93) is rotatably arranged on the bearing seat (82), the dressing frame (93) and the dressing frame (94) is hinged with the dressing frame (93), the dressing frame (93) and the dressing frame (94) is arranged on the side of the lifting frame (93), after the medicine feeding assembly (8) carries out medicine feeding operation on the medicine balloon (1), the working electric cylinder (91) drives the lifting frame (93) to move, when the working electric cylinder (91) moves, the blocking frame (92) limits the medicine balloon, the lifting frame (93) moves to enable the trimming press roller (94) to be in contact with the surface of the medicine balloon (1) full of medicines, then the electric sliding table (81) drives the bearing seat (82) to move to enable the trimming press roller (94) to move on the surface of the medicine balloon (1), so that the medicines in the concave structure (2) are compacted into the concave structure (2) of the medicine balloon (1), the phenomenon that the medicines are scattered when the medicine balloon (1) moves and is conveyed in a blood vessel is prevented, the scraper (95) can scrape the medicines attached to the trimming press roller (94), and the redundant medicines can be collected and processed when falling into the material receiving box (84), and the work is completed.
2. The method for preparing a drug balloon for a cerebral blood vessel according to claim 1, characterized in that: forming device (4) include drive assembly (5) and forming assembly (6), drive assembly (5) set up the top at workstation (3), forming assembly (6) set up on drive assembly (5) and with drive assembly (5) sliding fit, drive assembly (5) are including placing box (51), driving electric jar (52), limit baffle (53), drive block (54), spring (55) and two stopper (56), place box (51) and place the top at workstation (3), limit baffle (53) are fixed to be set up in placing box (51), driving electric jar (52) are fixed to be set up in placing box (51) and the flexible end and the limit baffle (53) sliding fit of driving electric jar (52), drive block (54) set up on the flexible end of driving electric jar (52) and with place box (51) sliding fit, the inside of drive block (54) is equipped with the recess, the both ends of spring (55) respectively with the inner wall in drive block (54) and place box (51) the recess and two corresponding stopper (56) are equipped with the drive block (51), the symmetry sets up two stopper (54) and the drive block (51) are connected.
3. The method for preparing a drug balloon for a cerebral blood vessel according to claim 2, characterized in that: shaping subassembly (6) are equipped with two sets ofly, and are two sets of shaping subassembly (6) symmetry slip sets up in placing box (51), and is two sets of shaping subassembly (6) all include mould frame (61) and hot plate (62) mould frame (61) slide and set up in placing box (51), be equipped with spout (611) on mould frame (61), be equipped with on drive block (54) with mould frame (61) spout (611) sliding fit's slider, mould frame (61) and the inner wall of placing box (51) form mould space (63), mould space (63) are circular, mould frame (61) and mould space (63) of placing the inner wall formation of box (51) are equipped with protruding (64) that the multiunit equidistant set up, hot plate (62) are fixed to be set up on limit baffle (53) and are located the side of mould space (63).
4. The method for preparing a drug balloon for a cerebral blood vessel according to claim 1, characterized in that: the positioning and rotating device (10) comprises a supporting plate (101), a rotating motor (102), a rotating clamping hand (103), a positioning seat (104), a lower piezoelectric cylinder (105) and a lower pressing block (106), wherein the supporting plate (101) and the positioning seat (104) are arranged at the top of the workbench (3), the supporting plate (101) and the positioning seat (104) are respectively located on two sides of the material receiving box (84), the rotating motor (102) is arranged on the supporting plate (101), a main shaft of the rotating motor (102) is in running fit with the supporting plate (101), the rotating clamping hand (103) is arranged on the main shaft of the rotating motor (102) and is in transmission fit with the main shaft of the rotating motor (102), the lower piezoelectric cylinder (105) is fixedly arranged on the positioning seat (104), the lower pressing block (106) is arranged on a telescopic end of the lower piezoelectric cylinder (105), a moving groove is formed in the positioning seat (104), the lower pressing block (106) is in sliding fit with the positioning seat, and a fixed hole is formed between the lower pressing block (106) and the positioning seat (104).
CN202210325132.6A 2022-03-30 2022-03-30 Drug balloon for cerebral blood vessels and preparation method thereof Active CN114699632B (en)

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CN114699632B true CN114699632B (en) 2023-03-10

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165206A (en) * 1955-12-20 1958-10-20 Sun Tube Corp Improvements to processes and devices for molding hollow bodies
CN102512747A (en) * 2011-12-27 2012-06-27 微创医疗器械(上海)有限公司 Medicine eluting balloon catheter
CN105150511A (en) * 2015-10-12 2015-12-16 夏钰钤 Medical balloon molding machine
CN112354070A (en) * 2020-12-04 2021-02-12 上海康德莱医疗器械股份有限公司 Preparation method of medicine balloon and medicine balloon prepared by preparation method
CN113577509A (en) * 2021-06-16 2021-11-02 上海脉全医疗器械有限公司 Medicine balloon

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165206A (en) * 1955-12-20 1958-10-20 Sun Tube Corp Improvements to processes and devices for molding hollow bodies
CN102512747A (en) * 2011-12-27 2012-06-27 微创医疗器械(上海)有限公司 Medicine eluting balloon catheter
CN105150511A (en) * 2015-10-12 2015-12-16 夏钰钤 Medical balloon molding machine
CN112354070A (en) * 2020-12-04 2021-02-12 上海康德莱医疗器械股份有限公司 Preparation method of medicine balloon and medicine balloon prepared by preparation method
CN113577509A (en) * 2021-06-16 2021-11-02 上海脉全医疗器械有限公司 Medicine balloon

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