CN114699564A

CN114699564A - Adhesion-enhanced lubricating coating, application thereof and medical interventional catheter

Info

Publication number: CN114699564A
Application number: CN202210415649.4A
Authority: CN
Inventors: 周容涛; 孙振龙; 石恒冲; 孙传盛; 王楠; 张帅; 闫顺杰; 栾世方; 殷敬华
Original assignee: Weigaozhi Interventional Medical Device Technology Shandong Co ltd; Weigao Holding Co ltd; Changchun Institute of Applied Chemistry of CAS
Current assignee: Weigaozhi Interventional Medical Device Technology Shandong Co ltd; Weigao Holding Co ltd; Changchun Institute of Applied Chemistry of CAS
Priority date: 2022-04-20
Filing date: 2022-04-20
Publication date: 2022-07-05
Anticipated expiration: 2042-04-20
Also published as: CN114699564B

Abstract

The invention provides a lubricating coating with enhanced adhesion, which comprises a bottom coating and a surface coating; the raw materials of the bottom layer coating comprise a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance; the raw materials of the surface coating layer comprise hydrophilic monomers, hydrophilic polymers and solvents. In the primer of the present invention, the curable polymer and the adhesion promoter may be physically bonded to each other or embedded to form an interpenetrating polymer network structure after curing. The primer layer may also form covalent bonds with the skin layer to form a stable network coating. The invention can realize the chemical bond fixation of the base coat on the surface of the substrate material and the internal self-crosslinking, improve the adhesion of the base coat to the substrate material, and improve the strength, the abrasion resistance and the shearing resistance of the coating. In addition, the bottom coating has long-acting antibacterial infection effect.

Description

Adhesion-enhanced lubricating coating, application thereof and medical interventional catheter

Technical Field

The invention relates to the technical field of biological materials, in particular to a lubricating coating with enhanced adhesion, application thereof and a medical interventional catheter.

Background

Interventional medical catheters are mostly made of high polymer materials, have low surface energy, strong hydrophobicity and large friction coefficient, and are easy to generate large friction with mucosa, cavities (especially blood vessels) and tissues in the process of interventional human body, thereby causing the damage of the mucosa of the cavities and even the rupture of the blood vessel wall. In order to solve the problem of overlarge friction force in the use process of the catheter, the hydrophilic lubricating coating can be prepared on the surface of the catheter by the method, so that the frictional resistance in the interpenetration process is reduced, the damage to mucosa and vascular walls is reduced, the pain of a patient is relieved, and the use safety is improved.

The surface of the catheter substrate material is coated with a hydrophilic coating with high adhesive force, which is an effective means for improving the lubricity and reducing the friction force of the interventional catheter. However, the polymer base material of the interventional medical catheter is rich in types, including but not limited to polyvinyl chloride (PVC), polyurethane (TPU), Polyethylene (PE), polypropylene (PP), Latex (Latex), silicone rubber, polyether block Polyamide (PEBAX), Polytetrafluoroethylene (PTFE), and Fluorinated Ethylene Propylene (FEP). The surface properties of different substrate materials are greatly different, so that the conventional coating liquid is difficult to form a high-adhesion lubricating coating on the surfaces of different materials.

At present, the application of a tackifying bottom layer on the surface of a substrate and the introduction of a hydrophilic lubricating surface layer have become the preferred option for obtaining a stable coating. International medicinal coating liquid geodesic (DSM), in WO 2007065722, WO 2008/104573, CN101970583 and CN102947376, discloses a process for the preparation of an article having a primer layer (also known as a primary coating) and a hydrophilic top coat. The bottom layer comprises a precoating layer consisting of polyurethane oligomer, polyvinylpyrrolidone (PVP) and a micromolecular photoinitiator, and can form a stable and firm hydrophilic lubricating coating with the surface coating. Although the polyurethane oligomer in the patent has good adhesion and has unsaturated groups which can realize photocuring to form a cross-linked structure, the acting force of the base coat and a substrate material in the system is mainly physical adsorption, and the problem of low coating firmness is easy to occur. In addition, the initiator adopted by the system is a micromolecular photoinitiator, and the migration phenomenon is easy to occur after the system is cured, so that the biological safety of the coating is reduced.

The company singapore jemet coating liquid discloses in patents WO 2016200337 and CN 107405430 a formulation of an adhesion promoting coating for use on a base material, which primer can be applied directly to different substrates to achieve strong adhesion between the substrate and the lubricating functional layer. The formulation includes a polymeric adhesion promoter, a first monomeric or polymeric crosslinking agent, and a photoinitiator. The polymeric adhesion promoter is a block copolymer comprising hydrophobic/hydrophilic polymer blocks and/or hydrophobic/hydrophilic functional groups, and the curable polymer and the adhesion promoter may be physically bonded to each other or embedded to form an interpenetrating polymer network structure after curing. The primer (tie coat) may also form covalent bonds with the topcoat (lubricious coat) to form a stable network coating. The adhesion of the coating of the system is improved, but the acting force of the base coat and the substrate material is still mainly physical action, and the problem of the small molecular initiator is not solved.

Patent CN 109954169 discloses a primer coating composition containing a novel photo-curable polyurethane, which contains tertiary amine groups on the main chain, unsaturated double bond groups and photosensitive group units on the side chain, and multiple crosslinking sites on the photo-curable polyurethane molecule, which can form a firm polymer film, and effectively improve the adhesion of hydrophilic lubricating coating on a substrate, especially a low surface energy substrate. Although the problem of photoinitiator precipitation is solved, the preparation of polyurethane with such a special structure involves a complex organic synthesis process, and has long technical route and strict requirements on reaction conditions, thereby causing great technical difficulty and high comprehensive cost in actual production.

Disclosure of Invention

In view of the above, the technical problem to be solved by the present invention is to provide an adhesion-enhanced lubricating coating, which has a photosensitive structural unit, is simple to construct, and solves the problems of residue and migration of a small molecule photoinitiator.

The invention provides a lubricating coating with enhanced adhesion, which comprises a bottom coating and a surface coating;

the raw materials of the bottom layer coating comprise a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance;

the raw materials of the surface coating layer comprise hydrophilic monomers, hydrophilic polymers and solvents.

Preferably, the photo-initiation type cationic species has the structure of formula a:

r is selected from

R₁And R₂Independently selected from H or C1-C4 alkyl; r₃Selected from C8-C12 alkyl;

x-is selected from Cl-or I-.

Preferably, in the primer coating:

the photo-initiation type cationic substance is selected from one or more of N- (4-benzoylbenzyl) -N, N-dimethyldodecyl-1-ammonium bromide, 4- (4- (diethylamino) benzoyl) -N, N-diethyl-N-octylphenyl ammonium iodide, N-dimethyl-N-octyl-9-oxo-9H-thiaanthracene-3-ammonium bromide and N-decyl-N, N-dimethyl-9, 10-dioxy-9, 10-dihydroanthracene-2-ammonium chloride;

the anion substance is one or more of low molecular weight heparin, fondaparinux, hyaluronic acid, chondroitin, dermatan sulfate and keratan sulfate;

the low molecular weight heparin comprises one or more of dalteparin, nadroparin and enoxaparin, and the average molecular weight is 3000-5000 KD;

the molecular weight of the fondaparinux is 1700 KD;

the molecular weight of the hyaluronic acid is 400000-1000000 KD;

the solvent is one or more of methanol, ethanol, isopropanol, chloroform, acetone and dimethyl sulfoxide.

Preferably, the mass of the light-triggered cationic substance and the mass of the anionic substance are (20-85): 100, respectively;

the mass ratio of the photo-initiation type anion-cation compound to the bottom coating is 0.02-25%.

The mass ratio of the hydrophilic monomer to the hydrophilic polymer is (0.01-15): (0.01-25).

Preferably, in the top coat:

the hydrophilic monomer comprises one or more of polyethylene glycol diacrylate, diethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate and ethoxylated trimethylolpropane triacrylate; the ethoxyl link number of the ethoxylated trimethylolpropane triacrylate is more than 9;

the hydrophilic polymer is selected from one or more of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide, polyacrylic acid, polyamide, polyether sulfone, polyimide, polyetherimide and polyththalamide;

the solvent is one or more of water, N-dimethylformamide, dimethyl sulfoxide, acetone, ethanol, methanol and isopropanol.

The invention provides application of the lubricating coating with enhanced adhesion in any technical scheme in preparation of a medical interventional catheter surface coating.

The invention provides a medical interventional catheter coated with the adhesion-enhanced lubricating coating in any one of the technical schemes.

The invention provides a preparation method of a medical interventional catheter coated with a lubricating coating with enhanced lubricating coating adhesion, which comprises the following steps:

A) reacting the photo-initiated cationic substance aqueous solution with the anionic substance aqueous solution to obtain an anion-cation compound;

B) dissolving the anion-cation complex in a solvent to obtain a bottom coating solution;

C) loading the bottom coating solution on a medical interventional catheter, and carrying out ultraviolet curing treatment to obtain the medical catheter with the bottom coating with enhanced adhesion;

D) and mixing the hydrophilic monomer solution and the hydrophilic polymer solution, loading the mixture on the surface of the medical catheter with the bottom coating with enhanced adhesion, and carrying out ultraviolet curing treatment to obtain the medical interventional catheter coated with the lubricating coating with enhanced adhesion of the lubricating coating.

Preferably, the step a) is specifically: dripping photo-initiated cationic substance water solution into anionic substance water solution, precipitating, washing precipitate, and freeze drying to obtain anionic-cationic complex.

Preferably, the concentration of the photo-initiation type cationic substance in the photo-initiation type cationic substance aqueous solution is 0.1-25 g/mL; the concentration of the anion substance in the anion substance water solution is 0.1-50 g/mL; the concentration of the anion-cation compound in the bottom layer coating solution is 0.02-25 g/mL;

the mass concentration of the hydrophilic monomer in the hydrophilic monomer solution is 0.01-15%; the mass concentration of the hydrophilic polymer in the hydrophilic polymer solution is 0.01-25%;

the supporting mode is selected from dipping, spraying, spin coating or wiping.

Preferably, the main transmission wavelength of the ultraviolet curing in the step C) is 150-430 nm, and the time of ultraviolet curing treatment is 2-15 min;

the light source of the ultraviolet light is one or more of a low-pressure mercury lamp, a medium-pressure mercury lamp, a high-pressure mercury lamp and a light filter.

Compared with the prior art, the invention provides a lubricating coating with enhanced adhesion, which comprises a bottom coating and a surface coating; the raw materials of the bottom layer coating comprise a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance; the raw materials of the surface coating layer comprise hydrophilic monomers, hydrophilic polymers and solvents. In the primer (tie coat) of the present invention, the curable polymer and adhesion promoter may be physically bonded to each other or embedded to form an interpenetrating polymer network structure after curing. The primer (tie coat) may also form covalent bonds with the topcoat (lubricious coat) to form a stable network coating. The photo-initiated anion-cation composite type bottom layer can generate Norrish II reaction and recombination reaction during curing, realizes chemical bond fixation of the bottom layer on the surface of a base material and self-crosslinking inside the coating, effectively improves the adhesion of the low coating to the base material, simultaneously increases the strength of the coating, and improves the abrasion resistance and the shearing resistance.

The photo-initiation type cationic substance adopted by the invention contains a photosensitive structural unit, a micromolecule photoinitiator is not required to be added, and the photo-initiation type cationic substance is cross-linked and limited in a coating network after photo-curing, so that the common problems of the small molecule photoinitiator in the industries such as residue, migration and the like in the coating are fundamentally solved. Meanwhile, due to the existence of the photo-initiation type cationic substance of the bottom layer formula, the invention can directly initiate the solidification of the hydrophilic monomer in the lubricating surface coating, so that an initiator can not be added in the surface coating formula, the problem of the photo-initiator is completely solved, and the overall biological safety of the coating is ensured. Compared with the existing single lubricating function coating formula, the cationic substance contained in the coating has high-efficiency antibacterial property, and meanwhile, the cationic substance is positioned in the inner layer of the coating and is coated by the outer lubricating layer, so that the problem that the naked antibacterial agent is inactivated and ineffective by biological molecules under complex physiological conditions can be avoided, and therefore, the coating has long-term anti-infection property, the occurrence of related infection of the medical catheter is reduced, and the service time of the medical catheter is prolonged.

Drawings

FIG. 1 is a schematic view of the construction of a "lubricating coating with enhanced adhesion and a medical interventional catheter with lubricating and antibacterial functions" coating;

FIG. 2 is a schematic diagram of a "common coating" construction;

FIG. 3 is a photograph of the platelet morphology of the surface of an untreated medical access tube;

FIG. 4 is a photograph of the morphology of platelets on the surface of a medical access tube having an adhesion-enhancing lubricious coating in accordance with an embodiment of the invention;

FIG. 5 is a photograph showing the number of colonies cultured on the surface of an untreated medical interventional tube;

FIG. 6 is a photograph of the number of colonies cultured on the surface of a medical access tube having an adhesion-enhancing lubricious coating in accordance with an embodiment of the invention;

FIG. 7 is a photograph of bacterial adhesion and death on the surface of an untreated medical access tube;

FIG. 8 is a photograph of bacterial adhesion and death on the surface of a medical access tube having a lubricious top coat and a conventional bottom coat in a control;

fig. 9 is a photograph of bacterial adhesion and death on the surface of a medical access tube having an adhesion enhancing lubricious coating obtained in accordance with an embodiment of the invention.

Detailed Description

The invention provides a lubricating coating with enhanced adhesion, application thereof and a medical interventional catheter, and a person skilled in the art can use the content for reference and appropriately improve the technological parameters to realize the purpose. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.

the raw materials of the bottom coating comprise a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance;

The surface coating has a lubricating function and can resist bacterial adhesion.

The invention provides a lubricating coating with enhanced adhesion, which comprises a bottom coating.

the bottom coating has a cationic sterilization function of a quaternary ammonium salt structure, and can perform a synergistic effect with an anti-adhesion function of the top coating, so that the anti-bacterial infection effect is improved. The cationic substance is positioned in the inner layer of the coating and is coated by the outer layer of the lubricating layer, so that the problem that the naked antibacterial agent is inactivated and ineffective by biological molecules under complex physiological conditions can be avoided, and the coating has long-term anti-infection property.

The light-initiated cationic substance has bactericidal property; the photo-initiation type cationic substance itself contains a photosensitive structural unit; the bottom coating is fixed on the surface of the substrate material by chemical bonds after being photocured; the bottom coating realizes the internal crosslinking of the coating by a photocuring mode. The whole double-layer structure coating has the effect of enhancing the adhesive force and has the functions of lubrication and antibiosis.

According to the invention, the photo-initiated cationic species has the formula a:

r is selected from

x-is selected from Cl-or I-.

The photo-initiation type cationic substance of the present invention is preferably one or more selected from the group consisting of N- (4-benzoylbenzyl) -N, N-dimethyldodecyl-1-ammonium bromide, 4- (4- (diethylamino) benzoyl) -N, N-diethyl-N-octylphenyl ammonium iodide, N-dimethyl-N-octyl-9-oxo-9H-thiaanthracene-3-ammonium bromide and N-decyl-N, N-dimethyl-9, 10-dioxy-9, 10-dihydroanthracene-2-ammonium chloride.

specifically, the low molecular weight heparin comprises one or more of dalteparin, nadroparin and enoxaparin, and the average molecular weight is 3000-5000 KD; the molecular weight of the fondaparinux is 1700 KD; the molecular weight of the hyaluronic acid is 400000-1000000 KD;

in the primer coating of the present invention, the solvent is preferably one or more of methanol, ethanol, isopropanol, chloroform, acetone, and dimethylsulfoxide.

The light-initiated cationic substance has bactericidal property; itself contains a photosensitive structural unit; the bottom coating is fixed on the surface of the substrate material by chemical bonds after being photocured; the bottom layer coating realizes the internal crosslinking of the coating in a photocuring mode.

The mass of the light-initiated cationic substance and the mass of the anionic substance are preferably (20-85): 100.

the mass ratio of the photo-initiation type anion-cation compound in the bottom coating is 0.02-25%.

The invention provides a lubricating coating with enhanced adhesion, which comprises a surface coating. The raw materials of the surface coating layer comprise hydrophilic monomers, hydrophilic polymers and solvents.

The top coat of the present invention has particularly good lubricating properties.

According to the invention, the mass ratio of the hydrophilic monomer to the hydrophilic polymer is preferably (0.01-15): (0.01-25).

Specifically, the hydrophilic monomer comprises one or more of polyethylene glycol diacrylate, diethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate and ethoxylated trimethylolpropane triacrylate; the ethoxylated trimethylolpropane triacrylate has an ethoxy linkage number greater than 9.

The hydrophilic polymer is selected from one or more of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide, polyacrylic acid, polyamide, polyether sulfone, polyimide, polyetherimide and polyphthalamide;

The hydrophilic monomer realizes crosslinking fixation through a photosensitive structural unit provided by a photo-initiated cationic substance.

The medical interventional catheter is not limited in the present invention, and those skilled in the art can understand the medical interventional catheter, including but not limited to balloon catheter, contrast catheter, micro-catheter, central venous catheter, and indwelling needle cannula.

The lubricating coating with enhanced adhesion can be coated on the surface of a medical interventional catheter, and can solve the problem of overlarge friction force in the use process of the catheter.

The lubricating coating of the present invention may comprise a base coat (tie coat) and a top coat (lubricating coat). The base coat is formed by curing an adhesion-promoting coating formulation comprising. In the primer layer (tie coat layer), the curable polymer and the adhesion promoter may be physically bonded to each other or embedded to form an interpenetrating polymer network structure after curing. The primer (tie coat) may also form covalent bonds with the topcoat (lubricious coat) to form a stable network coating.

The functional or lubricating coating provides lubricity to the composite coating, and the tackifying coating provides stability to the composite coating. By adjusting the degree of hydrophobic substitution of the hydrophilic polymer in the tie-coat, it is ensured that the surface of the tie-coat is well attached to widely used medical device substrates, such as metals, Polyurethanes (PU), polyvinyl chloride (PVC), rubbers, nylons, polypropylene, polyethylene thermoplastics, polyethylene (high density polyethylene and low density polyethylene), Fluorinated Ethylene Propylene (FEP), poly (ethylene-tetrafluoroethylene) (ETFE), poly (ethylene terephthalate) (PET), silicone elastomers, etc., some of which are highly hydrophobic (low surface energy), such as PP, HDPE, FEP and ETFE, so it is difficult to spontaneously diffuse the hydrophilic coating solution over the surface of these materials. Without wishing to be bound by theory, it is understood that this problem arises because the surface energy of these hydrophobic substrates is low relative to the surface energy of the solvent (which acts as part of the surface coating of the substrate). This makes it difficult to wet the substrate surface effectively. For example, the surface energy of the hydrophilic coating solution is higher than the surface energy of the substrate, so it is necessary to modify the surface energy of the substrate surface in some way. In this case, the most common method for achieving good adhesion is a pretreatment such as surface oxidation or a plasma treatment for generating polar groups on the surface of the substrate. However, such a pre-treatment lubricious coating may be formed by curing a curable hydrophilic polymer, an initiator, and a solvent. Advantages of using a curable hydrophilic polymer with a crosslinker or curable polymer: the curable hydrophilic polymer may be crosslinked with a crosslinking agent or the curable polymer itself, stabilizing the overall polymer network structure (due to the crosslinking between the polymer components), and minimizing the volume of particles and less shedding and migration effects when the medical device is moved and placed within the body lumen of the human body.

The medical interventional catheter with the lubricating and antibacterial functions is described above.

The adhesion-enhanced lubricating coating according to any one of the above-mentioned embodiments of the present invention has been clearly described above, and will not be described herein again.

A) reacting a photo-initiated cationic substance aqueous solution with an anionic substance aqueous solution to obtain an anionic-cationic complex;

The invention provides a preparation method of a medical interventional catheter coated with a lubricating coating with enhanced lubricating coating adhesion, which comprises the following steps: and (3) reacting the photo-initiated cationic substance aqueous solution with the anionic substance aqueous solution to obtain the anionic-cationic complex.

The step A) of the invention is specifically as follows: dripping photo-initiated cationic substance water solution into anionic substance water solution, precipitating, washing precipitate, and freeze drying to obtain anionic-cationic complex.

Dropping to separate out white or light yellow precipitate, washing the precipitate with distilled water or ultrapure water, and freeze drying to obtain the composite.

The present invention has been described above clearly with respect to the photo-initiation type cationic species and the anionic species, and the description thereof is omitted.

According to the invention, the concentration of the photo-initiation type cationic substance in the photo-initiation type cationic substance aqueous solution is preferably 0.1-25 g/mL; more preferably 1-23 g/mL;

the concentration of the anion substance in the anion substance water solution is preferably 0.1-50 g/mL; more preferably 1 to 48 g/mL.

Dissolving the anion-cation complex in a solvent to obtain a bottom coating solution; the concentration of the anion-cation compound in the bottom layer coating solution is preferably 0.02-25 g/mL; more preferably 0.1 to 12 g/mL.

The primer coating solution is loaded on a medical interventional catheter. The supporting mode of the invention is selected from dipping, spraying, spin coating or wiping.

The medical interventional catheter is not limited, and is well known to those skilled in the art; some medical catheters with different materials can be understood, such as: indwelling needle cannulas, catheters and the like, and the materials can be silica gel and latex.

The coating of the invention is coated on the pipe, and the whole coating can be coated or half coated or selected, and the mass of the coating can be 0.2-25% of the mass of the catheter.

And then carrying out ultraviolet curing treatment to obtain the medical catheter with the bottom coating with enhanced adhesion.

After the catheter with the anion-cation compound coating is obtained, the catheter with the compound is subjected to ultraviolet curing treatment to obtain the catheter with the bottom coating with the cross-linked structure and enhanced adhesion.

In the invention, the light source of the ultraviolet light is preferably one or more of a low-pressure mercury lamp, a medium-pressure mercury lamp, a high-pressure mercury lamp and a filter. The main transmission wavelength of the ultraviolet light adopted by the ultraviolet curing treatment is preferably 150-430 nm, and more preferably 200-380 nm; the time of the ultraviolet curing treatment is preferably 2-15 min, and more preferably 3-8 min.

After the ultraviolet curing treatment, the present invention preferably washes and dries the ultraviolet cured treatment product in this order. The cleaning conditions comprise water bath, water bath oscillation and ultrasonic cleaning, and the invention preferably adopts ethanol and deionized water to clean in sequence under the water bath oscillation condition to obtain the cleaned coating. In the invention, the frequency of the water bath oscillation is preferably 100-200 Hz, and more preferably 120-150 Hz; the cleaning time of the ethanol is preferably 15-60 min, and more preferably 30-40 min; the time for cleaning with the deionized water is preferably 10-50 min, and more preferably 25-30 min. The amount of ethanol and deionized water used for cleaning is not particularly limited. In the invention, the drying is preferably vacuum drying, and the drying time is preferably 12-30 hours, and more preferably 24-28 hours; the drying temperature is preferably 45-80 ℃, and more preferably 60-70 ℃.

A hydrophilic monomer solution is mixed with a hydrophilic polymer solution and loaded onto the surface of a medical catheter having an adhesion enhancing primer coating.

The solvent in the hydrophilic monomer solution of the present invention is preferably one or more of water, N-dimethylformamide, dimethyl sulfoxide, acetone, ethanol, methanol and isopropanol.

The mass concentration of the hydrophilic monomer in the hydrophilic monomer solution is 0.01-15%; more preferably 0.1 to 10 g/mL. The mass concentration of the hydrophilic polymer in the hydrophilic polymer solution is 0.01-25%; more preferably 1 to 15 g/mL.

And then carrying out ultraviolet curing treatment to obtain the medical interventional catheter coated with the lubricating coating with the enhanced lubricating coating adhesion.

The main transmission wavelength of the ultraviolet light adopted by the ultraviolet curing treatment is preferably 150-430 nm, and more preferably 200-380 nm; the time of the ultraviolet curing treatment is preferably 2-15 min, and more preferably 3-8 min.

After the ultraviolet curing treatment, the present invention preferably washes and dries the ultraviolet cured treatment product in this order. The cleaning conditions comprise water bath, water bath oscillation and ultrasonic cleaning, and the invention preferably adopts ethanol and deionized water to clean in sequence under the water bath oscillation condition to obtain the cleaned coating. In the invention, the frequency of the water bath oscillation is preferably 100-200 Hz, and more preferably 120-150 Hz; the time for cleaning the ethanol is preferably 15-60 min, and more preferably 30-40 min; the time for cleaning with the deionized water is preferably 10-50 min, and more preferably 25-30 min. The amount of ethanol and deionized water used for cleaning is not particularly limited. In the invention, the drying is preferably vacuum drying, and the drying time is preferably 12-30 hours, and more preferably 24-28 hours; the drying temperature is preferably 45-80 ℃, and more preferably 60-70 ℃.

The invention provides a lubricating coating with enhanced adhesion, which comprises a bottom coating and a surface coating; the raw materials of the bottom layer coating comprise a photo-initiation type anion-cation compound and a solvent; the photo-initiation type anion-cation compound comprises a photo-initiation type cation substance and an anion substance; the raw materials of the surface coating layer comprise hydrophilic monomers, hydrophilic polymers and solvents. In the primer (tie coat) of the present invention, the curable polymer and adhesion promoter may be physically bonded to each other or embedded to form an interpenetrating polymer network structure after curing. The base coat (tie coat) may also form covalent bonds with the top coat (lubricious coat) to form a stable network coat. The photo-initiated anion-cation composite type bottom layer can generate Norrish II reaction and recombination reaction during curing, realizes chemical bond fixation of the bottom layer on the surface of a base material and self-crosslinking inside the coating, effectively improves the adhesion of the low coating to the base material, simultaneously increases the strength of the coating, and improves the abrasion resistance and the shearing resistance.

To further illustrate the present invention, an enhanced adhesion lubricious coating, its use, and a medical interventional catheter are provided in the following examples.

Example 1

A) Preparing an N- (4-benzoylbenzyl) -N aqueous solution with the concentration of 0.8g/mL, and preparing a heparin sodium solution with the concentration of 1.5 g/mL; dropwise adding the aqueous solution of the N- (4-benzoylbenzyl) -N into 10ml of heparin sodium solution until a large amount of white precipitate is separated out from the solution, standing for 2h, and filtering to obtain the white precipitate. Washing the precipitate with ultrapure water for 3 times, and freeze drying to obtain the anion-cation complex.

B) Dissolving the anion-cation complex obtained in the step A) in an ethanol solution to prepare an anion-cation complex solution with the concentration of 8 g/mL; soaking polyurethane central venous catheter (weight X0) in the above compound solution for 45min, standing at 25 deg.C to completely volatilize ethanol solvent, and obtaining coated central venous catheter (weight X1) physically adsorbing anion-cation compound.

C) Irradiating the central venous catheter loaded with the compound for 5min under a high-pressure mercury lamp with the wavelength of 365nm and the power of 320W, and carrying out a bonding reaction on N- (4-benzoylbenzyl) -N, heparin sodium and the substrate under the excitation of ultraviolet to obtain a bottom coating with an enhanced adhesion and a cross-linked structure on the surface of the central venous catheter. Then, the central venous catheter is washed by ethanol and deionized water respectively 3 times under the condition of water bath ultrasound of 150Hz, and each time lasts for 8 min; vacuum drying at 60 ℃ for 24h then resulted in a coated central venous catheter with a moderate modulus ((weight X2) with a crosslinked structure.

D) Preparing a polyethylene glycol aqueous solution with the concentration of 0.2g/mL, preparing a diethylene glycol dimethacrylate solution with the concentration of 1g/mL, mixing the solutions, dip-coating the mixed solutions on the surface of the central venous catheter fixed with the tackifying bottom layer, irradiating the surface of the central venous catheter for 8min by using a high-pressure mercury lamp with the wavelength of 365nm and the power of 330W, and then ultrasonically oscillating and washing the central venous catheter by using ethanol and deionized water to obtain the central venous catheter (with the weight of X3) with a double-layer coating structure of a lubricating surface coating and a bottom coating with enhanced adhesion.

Example 2

A) Preparing an acetone solution of N-diethyl-N-octylphenyl ammonium iodide with the concentration of 3g/mL, and preparing a sodium hyaluronate aqueous solution with the concentration of 12 g/mL; dropwise adding the aqueous solution of the N-diethyl-N-octylphenyl ammonium iodide into 25ml of sodium hyaluronate solution until a large amount of white precipitate is separated out from the solution, standing for 3.5h, and filtering to obtain the white precipitate. Washing the precipitate with ultrapure water for 3 times, and freeze drying to obtain the anion-cation complex.

B) Dissolving the anion and cation compound obtained in the step A) in an acetone solution to prepare an anion and cation compound solution with the concentration of 12 g/mL; soaking polyurethane venous indwelling needle cannula (weight X0) in the compound solution for 60min, standing at 25 deg.C to completely volatilize acetone solvent, and obtaining venous indwelling needle cannula (weight X1) with coating for physically adsorbing anion and cation compound.

C) Placing the vein indwelling needle cannula loaded with the compound under a high-pressure mercury lamp with the wavelength of 235nm and the power of 380W for irradiating for 3min, carrying out bonding reaction on N-diethyl-N-octylphenyl ammonium iodide, sodium hyaluronate and a substrate under ultraviolet excitation, and obtaining a bottom layer coating with a cross-linked structure and enhanced adhesion on the surface of the vein indwelling needle cannula. Then, the venous indwelling needle sleeve is washed by ethanol and deionized water respectively for 3 times under the condition of 120Hz water bath ultrasound, and each time lasts for 15 min; the resulting coating was then vacuum dried at 65 ℃ for 24h to yield a moderate modulus vein-retaining needle cannula with a cross-linked structure (weight X2).

D) Preparing a polyacrylamide ethanol solution with the concentration of 2.5g/mL, preparing a trimethylolpropane triacrylate solution with the concentration of 1.8g/mL, mixing the solutions, dip-coating the mixed solutions on the surface of the vein indwelling needle cannula fixed with the tackifying bottom layer, irradiating the vein indwelling needle cannula with a high-pressure mercury lamp with the wavelength of 365nm and the power of 330W for 8min, and then ultrasonically oscillating and washing the vein indwelling needle cannula with ethanol and deionized water to obtain the vein indwelling needle cannula (the weight is X3) with a double-layer coating structure of a lubricating surface coating and a bottom coating with enhanced adhesion.

Example 3

A) Preparing 0.5 g/mL-ethanol solution of N-dimethyldodecyl-1-ammonium bromide, and preparing 1.5 g/mL-methanol solution of chondroitin; dropwise adding the aqueous solution of the N-dimethyldodecyl-1-ammonium bromide into 5ml of chondroitin solution until a large amount of white precipitate is separated out from the solution, standing for 1.5h, and filtering to obtain the white precipitate. Washing the precipitate with ultrapure water for 3 times, and freeze drying to obtain the anion-cation complex.

B) Dissolving the anion and cation compound obtained in the step A) in a methanol solution to prepare an anion and cation compound solution with the concentration of 0.8 g/mL; soaking PVC catheter (weight X0) in the above compound solution for 60min, standing at 25 deg.C to completely volatilize methanol solvent, and obtaining PVC catheter (weight X1) with coating physically adsorbing anion and cation compound.

C) Placing the PVC catheter loaded with the compound under a medium-pressure mercury lamp with the wavelength of 240nm and the power of 200W for irradiating for 8min, and carrying out a bonding reaction on N-dimethyldodecyl-1-ammonium bromide, chondroitin and a substrate under ultraviolet excitation to obtain a primer coating with a cross-linked structure and enhanced adhesion on the surface of the PVC catheter. Then, washing the PVC catheter with ethanol and deionized water respectively for 3 times, 20min each time, under the ultrasonic condition of 180Hz water bath; then vacuum drying at 50 ℃ for 24h to obtain the PVC catheter with the coating layer with the moderate modulus and the cross-linked structure (weight X2).

D) Preparing 0.3g/mL polyvinylpyrrolidone methanol solution, preparing 1.2g/mL polyethylene glycol diacrylate solution, mixing the solutions, dip-coating the mixed solutions on the surface of the vein indwelling needle sleeve fixed with the tackifying bottom layer, irradiating for 3min by using a high-pressure mercury lamp with the wavelength of 246nm and the power of 330W, and then ultrasonically oscillating and washing by using ethanol and deionized water to obtain the PVC catheter (the weight is X3) with a double-layer coating structure of a lubricating surface coating and an adhesion-enhanced bottom coating.

Example 4

A) Preparing 1.5g/mL of N- (4-benzoylbenzyl) -N acetone solution, and preparing 1.5g/mL of sodium hyaluronate aqueous solution; dropwise adding the aqueous solution of the N- (4-benzoylbenzyl) -N into 8ml of sodium hyaluronate solution until a large amount of white precipitate is separated out from the solution, standing for 2h, and filtering to obtain the white precipitate. Washing the precipitate with ultrapure water for 3 times, and freeze drying to obtain the anion-cation complex.

B) Dissolving the anion and cation compound obtained in the step A) in an ethanol solution to prepare an anion and cation compound solution with the concentration of 8 g/mL; soaking polyurethane venous indwelling needle cannula (weight X0) in the above compound solution for 60min, standing at 25 deg.C to completely volatilize ethanol solvent, and obtaining venous indwelling needle cannula (weight X1) with coating for physically adsorbing anion and cation compound.

C) Placing the vein indwelling needle cannula loaded with the compound under a high-pressure mercury lamp with 365nm of wavelength and 320W of power for irradiating for 3min, and carrying out bonding reaction on N- (4-benzoyl benzyl) -N, sodium hyaluronate and a substrate under ultraviolet excitation to obtain a primer coating with a cross-linked structure and enhanced adhesion on the surface of the vein indwelling needle cannula. Then, the venous indwelling needle sleeve is washed by ethanol and deionized water respectively for 3 times under the condition of water bath ultrasound at 150Hz, and each time lasts for 8 min; the resulting coated vein indwelling needle cannula with a cross-linked structure was then vacuum dried at 60 ℃ for 24h to give a moderate modulus ((weight X2).

D) Preparing a polyvinylpyrrolidone isopropanol solution with the concentration of 3.5g/mL, preparing a diethylene glycol dimethacrylate solution with the concentration of 1g/mL, mixing the solutions, dip-coating the mixed solutions to a vein remaining needle cannula fixed with a tackifying bottom layer, irradiating the vein remaining needle cannula with a high-pressure mercury lamp with the wavelength of 365nm and the power of 330W for 10min, and then ultrasonically oscillating and washing the vein remaining needle cannula with ethanol and deionized water to obtain the vein remaining needle cannula (the weight is X3) with a double-layer coating structure of a lubricating surface coating and a primer coating with enhanced adhesion.

Example 5 Performance testing

1) Coating adhesion test:

the medical interventional catheter (weight X1) loaded with the anion-cation compound intermediate coating prepared in the example 1 to 4, the medical interventional catheter (weight X2) loaded with the primer coating with the enhanced adhesion and the medical interventional catheter (weight X3) loaded with the double-layer coating structure of the lubricating surface coating and the primer coating with the enhanced adhesion and the medical interventional catheter (weight Y1) loaded with the control group and the common coating are respectively treated in an ultrasonic cleaner for 10min and 60min, and then are dried in vacuum at 60 ℃ for 24h, and then weighed (the weights are X4, X5, X6 and Y2). And (3) calculating the retention rate of the coating, wherein the calculation formula of the medical interventional catheter loaded with the intermediate coating is as follows: the coating retention rate is 1 (%) (X4-X0/X1-X0) × 100%; the calculation formula of the medical intervention catheter loaded with the primer coating with the crosslinking structure with enhanced adhesion is as follows: the coating retention rate was 2 (%) (X5-W0/X2-W0) × 100%; the calculation formula of the medical interventional catheter of a double-layer coating structure loaded with a lubricating surface coating and an adhesion-enhanced base coating is as follows: the coating retention rate was 3 (%) (X6-W0/X3-W0) × 100%; the calculation formula for the medical interventional catheter loaded with the common coating in the control group is as follows: the coating retention ratio was 4 (%) (Y2-W0/Y1-W0) × 100%. Results are shown in Table 1, which is the coating retention of medical interventional catheters having a two-layer coating structure with a lubricious topcoat layer and an adhesion-promoting basecoat layer obtained in examples 1-4 of the present invention.

TABLE 1 coating Retention for medical interventional catheters having a two-layer coating structure with a lubricious topcoat coating and an adhesion enhancing basecoat obtained in examples 1-4 of the present invention

As can be seen from Table 1, the medical interventional catheter with the double-layer coating structure of the lubricating surface coating and the adhesion-enhanced base coating has the coating retention rates of 99.5 percent and 98.8 percent respectively after 10min and 60min of ultrasound, while the retention rates of the indwelling needle cannula coating of the intermediate coating which is only loaded in a physical mode are 43.2 percent and 26.1 percent respectively, wherein the coating retention rates of the medical interventional catheter loaded with the common coating in a control group are 62.1 percent and 46.4 percent respectively, which shows that the double-layer coating structure of the lubricating surface coating and the adhesion-enhanced base coating provided by the invention has higher substrate adhesion and stability of the coating.

2) Coating lubricity test 1:

the present invention was carried out by measuring the friction coefficient of the medical interventional catheter (example group) having the double-layer coating structure of the lubricating top coating and the adhesion-enhancing base coating, the medical interventional catheter (control group) having the double-layer coating structure of the same lubricating top coating and the common base coating, and the unmodified medical interventional catheter (unmodified group) in example 1 using an MXD-02 friction coefficient meter. Firstly, respectively carrying out ultrasonic cleaning on the 3 groups of medical interventional catheters for 3 times, each time for 15min, then fixing the catheters on a groove plate, and injecting water into a water storage tank until a sample is completely soaked in the water storage tank. 200g of standard slide block is lightly put above the sample, the slide block is dragged by a sensor connecting rod to move at the speed of 100mm/min, the dynamic friction coefficient is measured, and the steps are repeated, the results are shown in tables 2-1 and 2-2, and the tables 2-1 and 2-2 are the friction coefficients of the lubricating coating with enhanced adhesion and the medical interventional catheter with the lubricating and antibacterial functions.

TABLE 2-1 Friction coefficient of lubricating coating with enhanced adhesion and medical interventional catheter with lubricating and antibacterial functions (first cleaning)

TABLE 2-2 Friction coefficient of enhanced adhesion lubricious coating and its medical interventional catheter with lubricious antimicrobial function (second Wash)

The experimental results show that the adhesion force and the lubricity of the adhesion-enhanced lubricating coating and the medical interventional catheter coating with the lubricating and antibacterial functions of the lubricating coating in example 1 are not affected by multiple times of ultrasonic cleaning and soaking in water, the friction coefficient is not changed obviously, the friction coefficient of the adhesion-enhanced lubricating coating and the medical interventional catheter coating with the lubricating and antibacterial functions of the lubricating coating is only about one percent of that of a common catheter, and the fact that the lubricating coating is firmly combined with the catheter wall and the coating is high in stability is proved. After multiple times of ultrasonic cleaning, the lubricating surface coating of the common catheter with the base coating falls off due to the low adhesion of the base coating and the infirm coating, and the lubricating performance is reduced and the friction coefficient is gradually increased along with the increase of the ultrasonic cleaning times.

3) Coating lubricity test 2:

the present invention was conducted to test the friction coefficient of the medical interventional catheters of example 1 (example group) having a two-layer coating structure including a lubricant top coating and an adhesion-enhancing primer coating, the single-layer coating medical interventional catheters having only an adhesion-enhancing primer coating (control group), and the unmodified medical interventional catheters (unmodified group) using an MXD-02 friction coefficient meter. Firstly, soaking the 3 groups of medical interventional catheters in clear water for 30s respectively, then fixing the catheters on a groove plate, and injecting water into a water storage tank until a sample is completely soaked in the water storage tank. 200g of a standard slide block is lightly placed above a sample, the slide block is dragged by a sensor connecting rod to move at a speed of 100mm/min, and the dynamic friction coefficient is measured, and the result is shown in table 3, wherein the table 3 shows the friction coefficient of the medical interventional catheter with the double-layer coating structure and the single-layer coating structure, wherein the medical interventional catheter is provided with a lubricating surface coating layer and an adhesion-enhanced base coating layer, and the friction coefficient of the medical interventional catheter is provided with only the adhesion-enhanced base coating layer.

TABLE 3 coefficient of friction for medical interventional catheters having a two-layer coating structure with a lubricious topcoat coating and an adhesion-enhancing basecoat coating versus a single-layer coated medical interventional catheter having only an adhesion-enhancing basecoat coating

Experimental results show that the single-layer coating medical interventional catheter with the primer coating with enhanced adhesion does not have good lubricating property, and the friction coefficient is not obviously changed compared with that of an unmodified sample. The medical interventional catheter with the double-layer coating structure of the lubricating surface coating and the adhesion-enhanced base coating has good lubricating performance, the lubricating coating is firmly combined with the catheter wall through the action of the base coating, and the lubricating coating and the catheter wall have obvious difference in the aspect of lubricating performance.

4) Coating safety test

The medical interventional catheters (examples) carrying the lubricating top coat and the primer coat with the enhanced adhesion and having the double-layer coating structure, the medical interventional catheters (control group) carrying the same lubricating top coat and the same common primer coat, and the unmodified medical interventional catheters (unmodified group) prepared in the examples 1 to 4 were subjected to an initiator precipitation detection test. Among them, the medical interventional catheters (control group) carrying the same lubricious topcoat layer and ordinary primer layer were fixed to the catheter surface by a small molecule photoinitiator. Respectively soaking the 3 groups of samples in aqueous solution for 6 hours under the ultrasonic conditions of the temperature of 60 ℃ and the power of 200w, taking the soaked solution, detecting the absorbance condition of each group of samples by an infrared spectrophotometer, and judging the precipitation condition of the micromolecular photoinitiator according to the peak value change. TABLE 4 initiator bleed for medical interventional catheters having a two-layer coating structure with a lubricious topcoat coating and an adhesion enhancing primer coating

TABLE 4 initiator bleed out for medical interventional catheters having a two-layer coating structure with a lubricious topcoat coating and an adhesion enhancing basecoat coating

Experimental results show that the medical interventional catheter with the double-layer coating structure, which is soaked for a long time and has the lubricating surface coating and the adhesion-enhanced base coating, has no initiator separated out, and shows that the light-initiated anion-cation compound type base layer can generate Norrish II reaction and recombination reaction during curing, so that the chemical bond fixation of the base coating on the surface of a base material and the self-crosslinking in the coating are realized, the adhesion of the low coating to the base material is effectively improved, the strength of the coating is improved, and the safety performance of the coating is improved.

5) Anticoagulant property test:

after incubating the medical interventional catheter with the double-layer coating structure prepared in the embodiment 1-4 in freshly prepared platelet-rich plasma at 37 ℃ for 60min, a scanning electron microscope is adopted to shoot the platelet morphology on the surface of the needle-sheathed catheter. To ensure the authenticity and reliability of the experiment, the data were obtained by averaging 3 replicates, wherein the untreated indwelling needle cannula was used as a negative control (manufacturer: Shandongwei high Cluster medical Polymer products, Ltd.). The results are shown in fig. 3-4, fig. 3 is a photograph of the platelet morphology on the surface of the untreated cannula, and fig. 4 is a photograph of the platelet morphology on the surface of the indwelling needle cannula having the double-layer coating structure obtained in example 2 of the present invention.

As can be seen from FIGS. 3 to 4, a large number of platelets are adhered to the surface of the untreated indwelling needle cannula, and the platelets are in a spreading and completely spreading activation state. The surface of the indwelling needle cannula with the double-layer coating structure obtained in the embodiment 2 of the invention is adhered with a few platelets, and the platelets are in a round and fusiform inactivated state. Considering that the adhesion and activation of blood platelets play an important role in the blood coagulation process, the indwelling needle cannula with the double-layer coating structure provided by the invention and provided with the lubricating surface coating and the adhesion-enhanced primer coating can reduce the occurrence probability of blood coagulation.

6) Antibacterial property test 1:

the medical interventional catheter with the double-layer coating structure and the medical interventional catheter without coating treatment prepared in the embodiments 1 to 4 were sterilized under the aseptic experimental condition at the concentration of 1X10⁶culturing the staphylococcus aureus in a cfu/mL LB nutrient solution for 24 hours, then taking out a catheter, carrying out low-power ultrasonic treatment and dilution, culturing the diluted bacterial liquid in a solid LB plate culture at 37 ℃ for 12 hours, counting bacterial colonies on a plate culture medium, and measuring the number of bacteria on the surface of the medical catheter, wherein FIG. 5 shows the bacterial colony condition after culturing the medical catheter without coating treatment, and FIG. 6 shows the bacterial colony condition after culturing the medical interventional catheter with a double-layer coating structure. The results are shown in table 4, with 3 replicates averaged.

TABLE 5 viable bacteria count on medical catheter surface

As can be seen from Table 5, even if no lubricant is added, the lubricant coating with enhanced adhesion and the medical interventional catheter with the lubricant and antibacterial functions can effectively reduce the number of live bacteria on the surface of the catheter. After lubricating oil is injected into the lubricating coating with enhanced adhesion and the medical interventional catheter with the lubricating and antibacterial functions, the number of living bacteria on the surface of the medical catheter is further reduced and is maintained at a very low level.

7) Antibacterial property test 2:

staphylococcus aureus was cultured at 37 ℃ in a sterile test operating environment, and the medical interventional catheters (example group) having a two-layer coating structure with a lubricating top coating and an adhesion-enhancing primer coating, the medical interventional catheters (control group) having a two-layer coating structure with a lubricating top coating and a normal primer coating, and the medical interventional catheters (unmodified group) having no coating treatment were immersed in a sterile test operating environment at a concentration of Staphylococcus aureus of 1X10⁶culturing in LB solution of cfu/mL at 37 deg.C for 6h, taking out, fixing with 4% paraformaldehyde for 4h, dehydrating with ethanol gradient, and observing the surface of the medical interventional catheter of the example group and the control group with scanning electron microscopeBacterial adhesion and death as in fig. 7, 8 and 9.

The experimental result shows that the condition of bacterial adhesion and death on the surface of the medical catheter of an unmodified group is shown in figure 7, and the result shows that a large amount of bacteria are adhered to the surface of the medical catheter which is not treated by the coating, and the shape of the bacteria is live bacteria; FIG. 8 shows the bacteria on the surface of a control group of medical interventional catheters with a double-layer structure of a lubricating top coating and a common bottom coating, and the results show that the lubricating top coating effectively inhibits the adhesion of bacteria, only a small amount of bacteria are adhered to the surface of the catheter, the adhered bacteria are all live bacteria in complete shapes because the bottom coating has no sterilization function, and the surface coating of the catheter of the control group only has an anti-adhesion function; FIG. 9 is a graph showing the bacteria on the surface of the catheter of the example group for medical intervention type having a two-layer coating structure of a lubricating top coat and an adhesion-enhancing bottom coat, showing that the lubricating top coat effectively inhibits the adhesion of bacteria, only a small amount of bacteria adheres to the surface of the catheter, and the bottom coat has a bactericidal function, so that the adhered bacteria are broken into dead bacteria in morphology, showing that the surface coating of the catheter of the example group is an anti-bactericidal binding surface.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. An enhanced adhesion lubricious coating comprising a primer coating and a topcoat coating;

2. A lubricating coating according to claim 1, characterised in that the photo-initiating cationic species has the formula a:

r is selected from

x-is selected from Cl-or I-.

3. The lubricating coating of claim 1, wherein in the primer coating:

the molecular weight of the fondaparinux is 1700 KD;

the molecular weight of the hyaluronic acid is 400000-1000000 KD;

4. The lubricating coating according to claim 1, wherein the mass of the photo-initiation type cationic species and anionic species is (20-85): 100, respectively;

the mass ratio of the photo-initiation type anion-cation compound to the bottom coating is 0.02-25%;

5. The lubricious coating of claim 1 wherein the top coating layer comprises:

6. Use of the enhanced adhesion lubricious coating of any of claims 1-5 in the preparation of a medical interventional catheter surface coating.

7. A catheter for medical intervention, characterized in that it is coated with the lubricant coating with enhanced adhesion of any one of claims 1 to 5.

8. A method for preparing a medical interventional catheter coated with a lubricious coating having enhanced lubricious coating adhesion, comprising:

9. The preparation method according to claim 8, wherein the step a) is specifically: dripping photo-initiated cationic substance water solution into anionic substance water solution, precipitating, washing precipitate, and freeze drying to obtain anionic-cationic complex.

10. The method according to claim 8, wherein the concentration of the photoinitiating cationic substance in the aqueous solution of the photoinitiating cationic substance is 0.1 to 25 g/mL; the concentration of the anion substance in the anion substance water solution is 0.1-50 g/mL; the concentration of the anion-cation compound in the bottom layer coating solution is 0.02-25 g/mL;

the supporting mode is selected from dipping, spraying, spin coating or wiping.

11. The preparation method according to claim 8, wherein the main transmission wavelength of the ultraviolet curing in the step C) is 150-430 nm, and the time of the ultraviolet curing treatment is 2-15 min;