CN114686578A - Skin type assessment method, application and system - Google Patents
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Abstract
The invention discloses a method, application and system for skin type assessment, wherein the method comprises the following steps: screening a gene sequence related to the skin type and a mutation site thereof; setting categories for the gene sequences based on the functions of the gene sequences and the mutation sites thereof; collecting a sample, and detecting a gene sequence and a mutation site of the sample; classifying the gene sequence and the mutation site of the sample based on the category to obtain the sample sequence under the category; based on the strength of the mutation sites in function, scoring sample sequences under the categories to obtain category scores; based on the categories and the category scores, skin types are assessed. The gene sequences are classified and scored by detecting the gene sequences and mutation sites of the samples to obtain quantitative data of skin types, and the skin types of the samples are accurately evaluated, so that the skin health management and nursing guidance are facilitated, the skin health degree is improved, and the skin health management or nursing guidance is facilitated.
Description
Technical Field
The invention relates to the field of biotechnology, in particular to a method, application and system for evaluating skin types.
Background
The skin, as the largest organ of the human body, not only plays the roles of perspiration, cold and heat feeling and pressure, but also plays the role of a 'protector', and effectively protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microbial attacks. Skin health is increasingly being viewed by people, and more time and resources are spent on skin management.
Healthy skin is not limited to skin diseases, but skin color, acne resistance, wrinkle resistance, moisture retention, and the like are all used as evaluation indexes of healthy skin. The health of the skin is related to various factors such as genetic genes related to the skin and their expression, the use of cosmetics, the use of right cosmetics, etc. Currently, there are reports at home and abroad about gene sequences related to skin, such as rs7501331, which has activity of converting carrot into retinol ester (vitamin a) cumulatively, activity of wild type C allele is higher than that of mutant type T allele, vitamin a can maintain skin mucosa integrity and play a role in resisting black and color spots, so that wild type C allele has stronger effect compared with mutant type T allele. Without being limited thereto, there are also various kinds of reports of skin-related genes. However, these gene sequences act relatively independently and have very little guidance for health management or care of the skin.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides a method and an application system for evaluating skin types, which are used for detecting collected samples and evaluating the types of the skins of the samples, and are beneficial to skin health management or nursing guidance.
The invention discloses a method for skin type assessment, which comprises the following steps: screening a gene sequence related to the skin type and a mutation site thereof; setting a category for the gene sequence based on the function of the gene sequence and its mutation site; collecting a sample, and detecting a gene sequence and a mutation site of the sample; classifying the gene sequence and the mutation site of the sample based on the category to obtain the sample sequence under the category; based on the strength of the mutation sites in function, scoring the sample sequences under the category to obtain category scores; based on the categories and the category scores, skin types are assessed.
Preferably, the method for detecting the gene sequence and the mutation site of the sample comprises the following steps:
constructing a gene chip based on the screened gene sequence and the mutation site thereof;
and detecting a sample gene sequence based on the gene chip, and obtaining the gene sequence of the sample and a mutation site thereof.
Preferably, the method for detecting the gene sequence and the mutation site of the sample comprises the following steps: collecting a saliva sample; extracting a sample genome; amplifying the genome to obtain a gene sample; hybridizing the gene chip with the gene sample; and obtaining a detection result through chip scanning, wherein the detection result comprises the sample gene sequence and the mutation site thereof.
Preferably, the method for scoring the gene sequences under the category comprises:
obtaining mutation sites and functions of the gene sequences;
quantifying based on the function strength of the mutation sites to obtain the scores of the gene sequences;
based on the score, a category score is obtained.
Preferably, the method of scoring the gene sequence comprises:
scoring the set site of the mutation site according to the function intensity;
obtaining a score of the gene sequence containing the mutation site according to the score:
wherein r is defined as the gene sequence, j is defined as the set-variable site, and n is defined as the total of the gene sequencesNumber, scorerScore expressed as the Gene sequencer,jExpressed as a quantification of the mutation site.
Preferably, the method of the present invention further comprises a method of ranking according to the category score: setting grades and grading intervals thereof; and acquiring the grade of the category score based on the grade and the scoring interval thereof.
Preferably, the method for obtaining the grade of the category score includes: in the gene chip, the number of mutation sites of a gene sequence is set to be 1-2; obtaining the average score of the classification according to the gene sequence score and the number of gene sequences under the classification; and acquiring the grade of the category score based on the grade and the scoring interval thereof.
Preferably, the categories include one or a combination of the following: anti-inflammatory and anti-acne, anti-wrinkle and anti-aging, anti-inflammatory and anti-acne, anti-black and anti-stain, oil control and moisture retention.
The invention also provides the use of the above method for skin care recommendations, including skin care ingredients and/or skin care recommendations.
The invention also provides a system for realizing the method, which comprises a preselection module, a detection module, a classification module, a scoring module and an evaluation module, wherein the preselection module is used for screening the gene sequence related to the skin type and the mutation site thereof, and setting the category for the gene sequence based on the functions of the gene sequence and the mutation site thereof; the detection module is used for detecting the gene sequence of the collected sample and the mutation site thereof; the classification module is used for classifying the gene sequence and the mutation site of the sample based on the category to obtain the sample sequence under the category; the scoring module is used for scoring the sample sequences under the category based on the strength of the mutation sites in function to obtain category scores; the assessment module is to assess a skin type based on the category and the category score.
Compared with the prior art, the invention has the beneficial effects that:
in the invention, a sample is collected, a gene sequence and a mutation site thereof are detected, and the gene sequence is classified and scored to obtain quantitative data of skin types, the skin types of the sample are accurately evaluated, which is beneficial to skin health management and care guidance, such as skin spot resistance classification, and when the score of the skin spot resistance is low, the skin of the sample is indicated to be easy to generate stripes, and the skin health degree is improved by paying attention to anti-spot management, and the skin health management or care guidance is facilitated.
Drawings
FIG. 1 is a flow chart of a method of skin type assessment of the present invention;
FIG. 2 is a flowchart of a method for detecting a gene sequence and a mutation site thereof;
FIG. 3 is a flowchart of a method for detecting the gene sequence and mutation site of the sample;
FIG. 4 is a flowchart of a method of scoring gene sequences under the categories;
FIG. 5 is a flow chart of a method for scoring the gene sequences;
FIG. 6 is a flow chart of a method for ranking based on the scoring of the gene sequences;
FIG. 7 is a logical block diagram of the system of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The invention is described in further detail below with reference to the attached drawing figures:
a method of skin type assessment, as shown in fig. 1, the method comprising:
step 101: and screening the gene sequence related to the skin type and the mutation site thereof. The gene sequences and the mutation sites thereof related to the skin types can be obtained from each public gene library or other public information, for example, the mutation site of rs7501331 is C/T, the mutation site of rs1801133 is C/G/T, and the mutation site of rs9923231 is G/A/T/C.
Step 102: based on the gene sequence and the function of the mutation site, a category is set for the gene sequence. For example, the categories include one or a combination of the following: anti-inflammatory, anti-acne, anti-wrinkle, anti-aging, anti-inflammatory, anti-acne, anti-black, anti-stain, oil control and moisturizing.
Step 103: collecting a sample, and detecting the gene sequence and the mutation site of the sample. In one embodiment, saliva samples are taken, but not limited to, skin samples, hair samples may also be taken. And an SNP database can be constructed according to the detected sample gene sequence and the mutation site thereof for data analysis.
Step 104: and classifying the gene sequences and the mutation sites of the samples based on the categories to obtain the sample sequences under the categories. The sample gene sequences may be matched to the screened gene sequences to obtain a classification of the sample gene sequences.
Step 105: and scoring the sample sequences under the categories based on the strength of the mutation sites on the functions to obtain category scores.
Step 106: based on the categories and the category scores, skin types are assessed.
In the invention, a sample is collected, a gene sequence and a mutation site thereof are detected, the gene sequence is classified and scored to obtain quantitative data of skin types, and the skin types of the sample are accurately evaluated, so that the skin health management and nursing guidance of the skin is facilitated, for example, when the skin types are classified as anti-spots and the score of the anti-spots is low, the skin of the sample is indicated to be easy to generate stripes, and the anti-spots management is required to be performed, so that the skin health degree is improved, and the skin health management or nursing guidance of the skin is facilitated.
The method for detecting the sample gene sequence and the mutation site thereof can be obtained by a gene sequencing method, as shown in fig. 2, or by a gene chip method:
step 201: and constructing a gene chip based on the screened gene sequence and the mutation site thereof.
Step 202: and detecting a sample gene sequence based on the gene chip, and obtaining the gene sequence of the sample and a mutation site thereof.
In one embodiment, as shown in fig. 3, the method for detecting the gene sequence and the mutation site of the sample comprises:
step 301: saliva samples were collected.
Step 302: and extracting a sample genome.
Step 303: and amplifying the genome to obtain a gene sample.
Step 304: and hybridizing with the gene sample through the gene chip.
The sequencing principle of gene chip (genechip) is the hybridization sequencing method, i.e. the method of determining the sequence of nucleic acid by hybridizing with a group of nucleic acid probes with known sequences, wherein the probes with target nucleotides with known sequences are fixed on the surface of a substrate.
Step 305: and obtaining a detection result by scanning the chip, wherein the detection result comprises a sample gene sequence and a mutation site thereof.
By the detection technology of the gene chip, the gene sequence of the sample and the mutation site thereof can be quickly obtained.
As shown in fig. 4, in step 105, the method for scoring the gene sequences under the categories comprises:
step 401: obtaining the mutation site and the function of the gene sequence.
Step 402: and quantifying based on the function strength of the mutation sites to obtain the scores of the gene sequences. If the mutation site of rs7501331 is the intensity of C and is greater than the intensity of T, then the score of C is greater than that of T.
Step 403: based on the score, a category score is obtained. And summarizing the gene sequences of the samples under the categories to obtain the scores of the categories. An assessment of the skin type is obtained by the category and its score.
Example 1
As shown in fig. 5, the present example provides a method for scoring the gene sequence, comprising:
step 501: and scoring the set site of the mutation site according to the function strength. Wherein the site score is used to reflect the strength of the function of the mutation site.
Step 502: obtaining a gene sequence score containing the mutation site according to the site score:
wherein r is defined as the gene sequence, j is defined as the set-variable site, n is defined as the total number of gene sequences, scorerScore expressed as the Gene sequencer,jExpressed as the score of the mutation site.
In one embodiment, the quantitative values of the weakest mutation sites are defined as 3, the quantitative values of the rest of the mutation sites are sequentially increased, and the quantitative values of the strongest work are 0, according to the sequential order of the functions from strong to weak, so that the mutation sites of the gene sequence are scored as follows:
scorer,j＝4-i
wherein i is a functional quantitative value of the mutation site, and can take values of 0-3, 4 quantitative values, r is a gene sequence, j is a mutation site, scorer,jExpressed as the score of the mutation site. I is defined as a quantitative value of the strength of function, and the score of the mutation site is inversely proportional to i, but is not limited thereto.
In one embodiment, the mutation site of the test sample is defined as TGr，jWherein r is a gene sequence, j is the number of the mutation site, and PG is defined as the mutation site of the screened gene sequencer，iTG (gamma-r，jAnd corresponding mutation site PGr，iMatching is carried out when the match is successful, i.e. TGr，j＝PGr，iThen scorer,j4-i; when the match is unsuccessful, i.e. TGr，j≠PGr，iThen scorer,j0, i.e. the function of the mutation site is unknown, or no quantitative value for the mutation site is defined.
Taking rs6259473 as an example, the quantitative model of the gene sequence mutation site is:
specifically, the sequences of the genes related to the skin types selected are shown in the following table:
| gene sequences | Gene action | Type of mutation | Strength and weakness of locus |
| rs7501331 | Black and stain resistance | C/T | C>T |
| rs1801133 | Anti-wrinkle and anti-aging | C/G/T | G>A>C |
| rs4654748 | Anti-inflammatory and anti-acne | A/C/G | C>T |
| rs6596473 | Black and stain resistance | G/A/T/C | G>A>C>T |
| rs2282679 | Anti-wrinkle and anti-aging | G/T | T>G |
| rs9923231 | Anti-wrinkle and anti-aging | G/A/T/C | C>A>G>T |
| rs13076312 | Anti-inflammatory and anti-acne | C/A/G/T | C>A>G>T |
| rs679620 | Anti-wrinkle and anti-aging | G/A/T/C | T>A>C>G |
| rs13208776 | Anti-wrinkle and anti-aging | G/A/T/C | G>A>C>T |
| rs722910 | Anti-wrinkle and anti-aging | G/A/T/C | A>C>G>T |
| rs11103631 | Oil control and moisture retention | G/A/T/C | A>C>G>T |
| rs2228000 | Anti-wrinkle and anti-aging | A/G | G>A |
| rs398123247 | Anti-inflammatory and anti-acne | C/G | C>G |
| rs6013897 | Anti-inflammatory and anti-acne | A/T | T>A>C>G |
But is not limited thereto.
Example 2
As shown in fig. 6, the present embodiment provides a method for rating according to the category score:
step 601: presetting the grade and the grading interval thereof.
Step 602: and acquiring the grade of the category score based on the grade and the scoring interval thereof. The category scoring is the quantification of the function intensity, and the grade of the category scoring is the qualitative judgment of the skin type, so that the qualitative analysis is facilitated.
In one embodiment, the method of ranking based on the score of the gene sequence comprises:
step 701: in the gene chip, the number of mutation sites of the gene sequence is set to be 1-2, so that the number of the mutation sites of the detected gene sequence is 1-2. Usually the number of mutation sites is 1-2; when the mutation sites of the screened gene sequences are more than 2, the scoring is not facilitated, and two gene sequences can be designed to be detected and calculated respectively.
Step 702: and obtaining the average score of the classification according to the gene sequence score and the gene sequence number under the classification.
Step 703: and acquiring the grade of the category score based on the grade and the scoring interval thereof. Such as score 7-9 as high, score 4-6 as medium, and score 1-3 as low.
In one particular embodiment, the ratings are as shown in the following table:
as can be seen from the table, the skin type of the sample was rated as 1.5 points for anti-inflammatory, anti-acne, anti-wrinkle, and anti-aging, and was rated low, and therefore, guidance opinions were given to skin health management or care, taking care of anti-inflammatory, anti-acne, anti-wrinkle, and anti-aging; oil control moisturization was rated 6.12 and high. Skin care products having anti-inflammatory, anti-acne, anti-wrinkle, anti-aging ingredients should be used.
The anti-inflammatory anti-acne, anti-wrinkle and anti-aging means that the gene sequence has two mutation sites, wherein one mutation site has the anti-inflammatory anti-acne function, and the other mutation site has the anti-wrinkle and anti-aging function.
The method can be applied to skin care recommendation, and compared with a skin detector, the method can better evaluate the skin type through the gene sequence and the mutation site thereof, and is not influenced by the environment and living habits. The evaluation of skin type is beneficial to improve the understanding of people on skin, thereby paying attention to skin care. Skin care recommendations may include dietary recommendations, skin care product ingredient recommendations, environmental recommendations, and skin care product recommendations. A preset recommendation can be set for the category rating or the category score, and a corresponding recommendation is matched according to a detection result, for example, a skin type with a low anti-inflammatory and anti-acne rating is recommended, and a skin conditioner with a strong anti-inflammatory and anti-acne function is recommended; in order to grade the skin type with low oil control and moisture retention, skin care product components with stronger oil control and moisture retention functions are recommended.
The invention also provides a system for implementing the method, as shown in fig. 7, comprising a preselection module 1, a detection module 2, a classification module 3, a scoring module 4 and an evaluation module 5,
the preselection module 1 is used for screening gene sequences related to skin types and mutation sites thereof, and setting categories for the gene sequences based on the functions of the gene sequences and the mutation sites thereof;
the detection module 2 is used for detecting the gene sequence of the collected sample and the mutation site thereof;
the classification module 3 is used for classifying the gene sequences and the mutation sites of the samples based on the classes to obtain sample sequences under the classes;
the scoring module 4 is used for scoring the sample sequences under the category based on the strength of the mutation sites in function to obtain category scores;
the assessment module 5 is for assessing the skin type based on the categories and the category scores.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method of skin type assessment, the method comprising:
screening a gene sequence related to the skin type and a mutation site thereof;
setting a category for the gene sequence based on the function of the gene sequence and its mutation site;
collecting a sample, and detecting a gene sequence and a mutation site of the sample;
classifying the gene sequence and the mutation site of the sample based on the category to obtain the sample sequence under the category;
based on the strength of the mutation sites in function, scoring the sample sequences under the category to obtain category scores;
based on the categories and category scores, skin types are assessed.
2. The method for skin type assessment according to claim 1, wherein the method for detecting said sample gene sequences and their mutation sites comprises:
constructing a gene chip based on the screened gene sequence and the mutation site thereof;
and detecting a sample gene sequence based on the gene chip, and obtaining the gene sequence of the sample and a mutation site thereof.
3. The method for skin type assessment according to claim 2, wherein the method for detecting said sample gene sequences and their mutation sites comprises:
collecting a saliva sample;
extracting a sample genome;
amplifying the genome to obtain a gene sample;
hybridizing the gene chip with the gene sample;
and obtaining a detection result through chip scanning, wherein the detection result comprises the sample gene sequence and the mutation site thereof.
4. The method for skin type assessment according to claim 1, wherein said method of scoring gene sequences under said category comprises:
obtaining mutation sites and functions of the gene sequences;
quantifying based on the function strength of the mutation sites to obtain the scores of the gene sequences;
based on the score, a category score is obtained.
5. The method of skin type assessment according to claim 4, wherein said method of scoring said gene sequences comprises:
scoring the set site of the mutation site according to the function intensity;
obtaining a score of the gene sequence containing the mutation site according to the score:
wherein r is defined as the gene sequence, j is defined as the set-variable site, n is defined as the total number of gene sequences, scorerScore expressed as the Gene sequencer,jExpressed as a quantification of the mutation site.
6. The method for skin type assessment according to claim 4, further comprising a method of ranking according to said category score:
setting grades and grading intervals thereof;
and acquiring the grade of the category score based on the grade and the scoring interval thereof.
7. The method for skin type assessment according to claim 6, wherein said ranking method for obtaining said category score comprises:
in the gene chip, the number of mutation sites of a gene sequence is set to be 1-2;
obtaining the average score of the classification according to the gene sequence score and the number of gene sequences under the classification;
and acquiring the grade of the category score based on the grade and the scoring interval thereof.
8. The method for skin type assessment according to claim 1, characterized in that said categories comprise one or a combination of the following: anti-inflammatory and anti-acne, anti-wrinkle and anti-aging, anti-inflammatory and anti-acne, anti-black and anti-stain, oil control and moisture retention.
9. Use of the method according to any one of claims 1 to 8 for skin care recommendations comprising skin care ingredients and/or skin care recommendations.
10. A system for implementing the method of any one of claims 1 to 8, comprising a pre-selection module, a detection module, a classification module, a scoring module and an assessment module,
the preselection module is used for screening gene sequences related to skin types and mutation sites thereof, and setting categories for the gene sequences based on the functions of the gene sequences and the mutation sites thereof;
the detection module is used for detecting the gene sequence of the collected sample and the mutation site thereof;
the classification module is used for classifying the gene sequence and the mutation site of the sample based on the category to obtain the sample sequence under the category;
the scoring module is used for scoring the sample sequences under the category based on the strength of the mutation sites in function to obtain category scores;
the assessment module is to assess a skin type based on the category and the category score.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| US20180328945A1 (en) * | 2015-11-10 | 2018-11-15 | Pathway Skin, Inc. | Methods and Systems for Improving Skin Condition |
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