CN114681100A

CN114681100A - Intelligent control drug delivery device for experimental mice

Info

Publication number: CN114681100A
Application number: CN202210350473.9A
Authority: CN
Inventors: 唐晖; 罗良平
Original assignee: Jinan University
Current assignee: Jinan University
Priority date: 2022-04-02
Filing date: 2022-04-02
Publication date: 2022-07-01

Abstract

The invention provides an intelligent control drug delivery device for an experimental mouse, which comprises: automatic irritate stomach and administer module, injection module, aerosol inhalation module, fixing support and controller of dosing, fixing support's top is fixed to be set up automatic irritate stomach and administer module, injection module, aerosol inhalation module and the controller of dosing, automatic irritate stomach and administer module, injection module and aerosol inhalation module electric connection of dosing the controller. The intelligent control drug delivery device for the experimental mouse can realize the gavage drug delivery, the injection drug delivery and the atomization inhalation drug delivery of the mouse, has a simple structure, is convenient to manufacture and use, and improves the accuracy of experimental data.

Description

Intelligent control drug delivery device for experimental mice

Technical Field

The invention relates to the technical field of biomedical experimental instruments, in particular to an intelligent control drug delivery device for an experimental mouse.

Background

Mice, also known as laboratory mice, white mice and white rats, are commonly used as laboratory animals in the teaching and research of physiological, medical, pharmaceutical and other disciplines. In the experimental process, the administration may need to be carried out to the mouse, the administration modes are various, different administration modes need to adopt different tools, the operation is inconvenient, for example, the intragastric administration needs to be carried out, the liquid medicine infusion needs to be carried out to the mouse, the prior intragastric administration device mostly uses a thick glove worn by an experimenter to grab the mouse for intragastric administration in the using process, the operation is inconvenient, for example, the injection administration needs to be carried out to the mouse, the prior injection device has the problems that the injection medicine can not be quantified and the injection needs to consume a large amount of manpower, for example, the atomization inhalation administration is the most uniform mode of the lung administration, the prior atomization inhalation administration device has certain defects, the mouse is easy to be held and pushed in a cluster when in use, or one part of the mouse is in a sleeping state and the other part of the mouse is in a waking state, so that the difference of the inhaled medicine amount between mouse individuals is large, leading to inaccurate experimental data. Therefore, it is necessary to design an intelligent control drug delivery device for experimental mice.

Disclosure of Invention

The invention aims to provide an intelligent control drug delivery device for an experimental mouse, which can realize the gavage drug delivery, the injection drug delivery and the atomization inhalation drug delivery of the mouse, has a simple structure, is convenient to manufacture and use, and improves the accuracy of experimental data.

In order to achieve the purpose, the invention provides the following scheme:

an intelligent control drug delivery device for laboratory mice, comprising: the automatic intragastric administration system comprises an automatic intragastric administration module, an injection administration module, an aerosol inhalation administration module, a fixed support and a controller, wherein the automatic intragastric administration module, the injection administration module, the aerosol inhalation administration module and the controller are fixedly arranged at the top of the fixed support, and the automatic intragastric administration module, the injection administration module and the aerosol inhalation administration module are electrically connected with the controller;

the automatic intragastric perfusion drug delivery module comprises a bottom plate, a support column, an electronic scale, a first electric telescopic rod, a lifting intragastric perfusion mechanism and a mouse fixing piece, wherein the bottom plate is fixedly arranged at the top of a fixing support, the electronic scale is fixedly arranged at the center of the top of the bottom plate, the mouse fixing piece is fixedly arranged at the center of the top of the electronic scale and used for fixing a mouse, the support column is fixedly arranged at one side of the top of the bottom plate, the first electric telescopic rod is fixedly arranged at the top of the support column, the lifting intragastric perfusion mechanism is fixedly arranged at the top of the first electric telescopic rod and corresponds to the mouse fixing piece, and the electronic scale, the first electric telescopic rod and the lifting intragastric perfusion mechanism are electrically connected with the controller;

the injection dosing module comprises an injection box, a medicine bin, a second electric telescopic rod and an injection part, an injection cavity is arranged in the injection box, a partition plate is arranged in the injection cavity and divides the injection cavity into an upper cavity and a lower cavity, the second electric telescopic rod is fixedly arranged in the lower cavity, the output end of the second electric telescopic rod penetrates through the partition plate and is arranged in the upper cavity, a second piston is fixedly connected with the output end of the electric telescopic rod, the medicine bin is arranged on one side of the injection box and is connected with the upper cavity through a T-shaped pipe, the upper cavity is connected with the injection part, electromagnetic valves are arranged on the T-shaped pipe and the injection part, and the second electric telescopic rod and the electromagnetic valves are electrically connected with the controller;

the atomizing inhalation module of dosing includes box, upper cover, atomizing host computer, rocks and holds device, temperature controller and heater, the inside of box sets up rock and hold device, temperature controller and heater, rock and hold the device and be used for holding the mouse and rock automatically, the top of box sets up the upper cover, the atomizing host computer pass through the spray tube with the inside of box is linked together for spout into the atomized medicine to the box is inside, the atomizing host computer, rock and hold device, temperature controller and heater electric connection the controller.

Optionally, the elevating gastric perfusion mechanism comprises a top plate, a limiting rod, a threaded rod, an L-shaped bracket, a rotating motor, a fixing rod, an injection tube, a one-way valve and a gastric perfusion needle, the top of the first electric telescopic rod is fixedly provided with the top plate, the bottom of the top plate is fixedly provided with the rotating motor, the limiting rod and the L-shaped bracket, the limiting rod is arranged on the left side of the rotating motor, the L-shaped bracket is arranged on the right side of the rotating motor, the injection tube is fixedly arranged on the L-shaped bracket and is connected with the gastric perfusion needle through the one-way valve, the position of the gastric perfusion needle corresponds to the position of the mouse fixing part, the output end of the rotating motor is fixedly provided with the threaded rod, the threaded rod is in threaded connection with a threaded block, the limiting block is in sliding connection with the limiting rod and is connected with the limiting block through a connecting rod, the left side of stopper is connected with the dead lever, the fixed first piston that is provided with on the dead lever, first piston setting is in the inside of injection tube, rotating electrical machines electric connection the controller.

Optionally, the mouse fixing part comprises a vertical fixing plate, a head fixing part, an opening assembly and a body fixing part, the vertical fixing plate is fixedly arranged at the center of the top of the electronic scale, and the opening assembly, the head fixing part and the body fixing part are sequentially arranged on the front side of the vertical fixing plate from top to bottom;

the opening assembly comprises a block body for enabling a mouse to open the mouth, a first fixing column and a first adjusting rod, the first fixing column is fixedly arranged on the upper side of the front face of the vertical fixing plate, a through hole is formed in the side face of the first fixing column, the first adjusting rod penetrates through the through hole to be connected with the block body and used for driving the block body to move left and right, a through hole is formed in the center of the upper side and the lower side of the block body and used for allowing the gastric perfusion needle to penetrate, and a screw hole is formed in the front face of the first fixing column and used for allowing a bolt to penetrate through to fix the first adjusting rod;

the head fixing pieces are provided with two groups and are respectively arranged on the left side and the right side of the lower side of the opening assembly, each head fixing piece comprises a second fixing column, a second adjusting rod and a head clamping piece, the second fixing columns are fixedly arranged on one side of the front face of the vertical fixing plate, through holes are formed in the side faces of the second fixing columns, the second adjusting rods penetrate through the through holes to be connected with the head clamping pieces and are used for driving the head clamping pieces to move left and right, and screw holes are formed in the front faces of the second fixing columns and are used for allowing bolts to penetrate through and fix the second adjusting rods;

the health mounting is provided with a plurality ofly, sets gradually respectively the downside of head mounting for fix the health of mouse, the health mounting is magic subsides bandage or buckle bandage.

Optionally, a drug inlet is arranged at the top of the drug bin, the drug inlet is connected with a drug inlet pipe for inputting drug liquid, an electromagnetic valve is arranged on the drug inlet pipe, a drug outlet is arranged at the bottom of the drug bin, the drug outlet is connected with the first end of the T-shaped pipe, the second end of the T-shaped pipe is connected with an upper chamber located on the lower side of the second piston, the third end of the T-shaped pipe is suspended and used for being connected with an external water source for cleaning, the electromagnetic valves are arranged at the first end, the second end and the third end of the T-shaped pipe, the injection component comprises an injection needle and a needle tube, the upper chamber located on the lower side of the second piston is connected with the needle tube, the needle tube is connected with the injection needle, the electromagnetic valve is arranged on the needle tube, the electromagnetic valve is electrically connected with the controller, and the joint of the second electric telescopic rod and the partition plate is mechanically sealed, the injection cavity is used for preventing liquid medicine from flowing into the lower cavity, an elastic sealing layer is arranged at the joint of the second piston and the upper cavity, the medicine cabin and the injection box are made of transparent materials, and scale marks are arranged outside the medicine cabin and the injection box corresponding to the upper cavity.

Optionally, it includes backup pad, baffle, third electric telescopic handle and bracing piece to rock and hold the device, the side sets up through the rotating member around the box is inside the bracing piece, the bracing piece passes the backup pad will the backup pad is rotatable to be set up the inside of box, the inside bottom of box sets up two third electric telescopic handle, two third electric telescopic handle's output is fixed connection respectively the bottom of backup pad, the top of backup pad is provided with four baffles, the baffle encloses with the backup pad and becomes to place the chamber for place the mouse.

Optionally, the fixing support comprises a first fixing plate, a second fixing plate and a fourth electric telescopic rod, the top of the first fixing plate is provided with four fourth electric telescopic rods and a controller, the output end of each fourth electric telescopic rod is fixedly provided with the second fixing plate, the top of the second fixing plate is fixedly provided with the automatic intragastric perfusion dosing module, the injection dosing module and the aerosol inhalation dosing module, the fourth electric telescopic rod is electrically connected with the controller, and the bottom of the first fixing plate is provided with universal wheels and brake pads for realizing the movement and fixation of the device.

According to the specific embodiment provided by the invention, the invention discloses the following technical effects: the intelligent control drug delivery device for the experimental mouse is provided with the automatic gavage drug delivery module, can realize gavage drug delivery of the mouse in the experimental process, fixes the mouse through the mouse fixing piece, opens the mouth of the mouse, and performs gavage drug delivery on the mouse through the lifting gavage mechanism, can determine the weight of liquid medicine to be filled in real time through the electronic scale, can realize accurate automatic control gavage drug delivery, and is simple and convenient; the device is provided with an injection dosing module, so that injection dosing can be performed on a mouse in an experimental process, the mouse is fixed on a mouse fixing piece, when the device is used, a controller controls a second electric telescopic rod to move upwards, liquid medicine in a medicine bin is sucked into an injection box, then the second electric telescopic rod is controlled to move downwards, the liquid medicine in the injection box is injected into the mouse body through an injection part, and accurate injection can be realized according to scales on the medicine bin and the injection box and weighing of an electronic scale; the device still is provided with the aerosol inhalation module of dosing, can realize the aerosol inhalation and dose, place the mouse during use and hold on the device rocking, can rock through the device, prevent that the mouse from holding a group and prick the heap, perhaps some mice are in the sleep state and another part is in the waking state, and then make the inspiratory dose of mouse between the individual relatively even, make experimental data more accurate, temperature sensor can the internal temperature of real-time detection box, when the temperature is low excessively, controller control heater begins, the going on of assurance experiment, improve the experiment accuracy.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a schematic structural view of an intelligent control drug delivery device for experimental mice according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of an automatic intragastric administration module;

FIG. 3 is a schematic view of an injection administration module;

fig. 4 is a schematic structural diagram of an aerosol inhalation administration module.

Reference numerals: 1. an automatic intragastric administration module; 2. an injection dosing module; 3. an aerosol inhalation dosing module; 4. a first fixing plate; 5. a second fixing plate; 6. a fourth electric telescopic rod; 7. a controller; 8. a universal wheel; 9. an upper cover; 10. a box body; 11. a baffle plate; 12. a support bar; 13. a support plate; 14. a third electric telescopic rod; 15. a heater; 16. an atomization host machine; 17. a nozzle; 18. a base plate; 19. an electronic scale; 20. a support pillar; 21. a first electric telescopic rod; 22. a top plate; 23. a rotating electric machine; 24. an L-shaped bracket; 25. a threaded rod; 26. a limiting rod; 27. a thread block; 28. a limiting block; 29. fixing the rod; 30. an injection tube; 31. a one-way valve; 32. a stomach filling needle; 33. a block body; 34. a first adjusting lever; 35. a first fixed column; 36. a second adjusting lever; 37. a second fixed column; 38. a body securing member; 39. a head clamp; 40. an injection box; 41. an upper chamber; 42. a lower cavity; 43. a medicine bin; 44. a medicine inlet pipe; 45. an electromagnetic valve; 46. a second electric telescopic rod; 47. a second piston; 48. a needle tube; 49. an injection needle; 50. a partition plate; 51. a vertical fixing plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention aims to provide an intelligent control drug delivery device for an experimental mouse, which can realize the gavage drug delivery, the injection drug delivery and the aerosol inhalation drug delivery of the mouse, has a simple structure, is convenient to manufacture and use, and improves the accuracy of experimental data.

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.

As shown in fig. 1, the intelligent control drug delivery device for experimental mice provided by the embodiment of the invention comprises: the automatic intragastric administration system comprises an automatic intragastric administration module 1, an injection administration module 2, an aerosol inhalation administration module 3, a fixed support and a controller 7, wherein the automatic intragastric administration module 1, the injection administration module 2, the aerosol inhalation administration module 3 and the controller 7 are fixedly arranged at the top of the fixed support, and the automatic intragastric administration module 1, the injection administration module 2 and the aerosol inhalation administration module 3 are electrically connected with the controller 7;

as shown in fig. 2, the automatic intragastric administration module 1 includes a bottom plate 18, a supporting pillar 13, an electronic scale 19, a first electric telescopic rod 21, a lifting intragastric administration mechanism and a mouse fixing member, the bottom plate 18 is fixedly disposed at the top of the fixing support, the electronic scale 19 is fixedly disposed at the top center of the bottom plate 18, the mouse fixing member is fixedly disposed at the top center of the electronic scale 19 and used for fixing a mouse, the supporting pillar 13 is fixedly disposed at one side of the top of the bottom plate 18, the first electric telescopic rod 21 is fixedly disposed at the top of the supporting pillar 13, the lifting intragastric administration mechanism is fixedly disposed at the top of the first electric telescopic rod 21, the lifting intragastric administration mechanism corresponds to the mouse fixing member, and the electronic scale 19, the first electric telescopic rod 21 and the lifting intragastric administration mechanism are electrically connected to the controller 7;

as shown in fig. 3, the injection administration module comprises an injection box 40, a drug bin 43, a second electric telescopic rod 46 and an injection part, the injection box 40 is provided with an injection cavity inside, the injection cavity is provided with a partition plate 50 inside, the partition plate 50 divides the injection cavity into an upper cavity 41 and a lower cavity 42, the second electric telescopic rod 46 is fixedly arranged in the lower cavity 42, the output end of the second electric telescopic rod 46 is arranged inside the upper chamber 41 through the partition plate 50, the output end of the electric telescopic rod 46 is fixedly connected with a second piston 47, one side of the injection box 40 is provided with the medicine bin 43, the drug bin 43 is connected with the upper cavity 41 through a T-shaped pipe, the upper cavity 41 is connected with the injection part, the T-shaped pipe and the injection part are both provided with an electromagnetic valve 45, and the second electric telescopic rod 46 and the electromagnetic valve 45 are electrically connected with the controller 7;

as shown in fig. 4, the atomization inhalation administration module comprises a box body 10, an upper cover 9, an atomization host 16, a containing device, a temperature controller and a heater 15, the box body 10 is internally provided with the containing device, the temperature controller and the heater 15, the containing device is used for containing a mouse and automatically shaking, the upper cover 9 is arranged at the top of the box body 10, the atomization host 16 is communicated with the inside of the box body 10 through a spray pipe 17 and used for spraying atomized medicines into the box body 10, and the atomization host 16, the containing device, the temperature controller and the heater 15 are electrically connected with the controller 7.

As shown in fig. 2, the elevating gastric perfusion mechanism comprises a top plate 22, a limiting rod 26, a threaded rod 25, an L-shaped bracket 24, a rotating motor 23, a fixing rod 29, an injection tube 30, a one-way valve 31 and a gastric perfusion needle 32, wherein the top of the first electric telescopic rod 21 is fixedly provided with the top plate 22, the bottom of the top plate 22 is fixedly provided with the rotating motor 23, the limiting rod 27 and the L-shaped bracket 24, the limiting rod 27 is arranged on the left side of the rotating motor 23, the L-shaped bracket 24 is arranged on the right side of the rotating motor 23, the injection tube 30 is fixedly arranged on the L-shaped bracket 24, the injection tube 30 is connected with the gastric perfusion needle 32 through the one-way valve 31, the position of the gastric perfusion needle 32 corresponds to the position of the mouse fixing member, the threaded rod 25 is fixedly arranged at the output end of the rotating motor 23, and a threaded block 27 is connected to the threaded rod 25 by a thread, a limit block 28 is slidably connected to the limit rod 26, the thread block 27 is connected to the limit block 26 through a connecting rod, a fixing rod 29 is connected to the left side of the limit block 26, a first piston is fixedly arranged on the fixing rod 29 and arranged inside the injection cylinder 30, and the rotating motor 23 is electrically connected to the controller 7; the syringe 30 may be provided with an injection port for injecting an injection medicament.

The mouse fixing part comprises a vertical fixing plate 51, a head fixing part, an opening assembly and a body fixing part 38, the vertical fixing plate is fixedly arranged at the center of the top of the electronic scale 19, and the opening assembly, the head fixing part and the body fixing part 38 are sequentially arranged on the front surface of the vertical fixing plate from top to bottom;

the opening assembly comprises a block 33 for opening the mouth of a mouse, a first fixing column 35 and a first adjusting rod 34, the first fixing column 35 is fixedly arranged on the upper side of the front face of the vertical fixing plate 51, a through hole is formed in the side face of the first fixing column 35, the first adjusting rod 34 penetrates through the through hole to be connected with the block 33 and used for driving the block 33 to move left and right, a through hole is formed in the center of the upper side and the lower side of the block 33 and used for allowing the gastric perfusion needle 32 to penetrate through, and a screw hole is formed in the front face of the first fixing column 35 and used for allowing a bolt to penetrate through to fix the first adjusting rod 34;

the head fixing pieces are provided with two groups and are respectively arranged on the left side and the right side of the lower side of the opening assembly, each head fixing piece comprises a second fixing column 37, a second adjusting rod 36 and a head clamping piece 39, the second fixing column 37 is fixedly arranged on one side of the front face of the vertical fixing plate 51, a through hole is formed in the side face of the second fixing column 37, the second adjusting rod 36 penetrates through the through hole to be connected with the head clamping piece 39 and is used for driving the head clamping piece 39 to move left and right, and a screw hole is formed in the front face of the second fixing column 37 and is used for allowing a bolt to penetrate through to fix the second adjusting rod 36;

the head clamping piece 39 can be a semi-circular ring type clamping piece, and the two semi-circular rings are matched to fix the head of the mouse;

the body fixing member 38 is provided with a plurality of body fixing members, which are respectively and sequentially arranged at the lower side of the head fixing member, and used for fixing the body of the mouse, and the body fixing member is a hook and loop tape or a buckle tape.

The automatic intragastric administration module has the working process that: firstly, fixing a mouse on a mouse fixing piece, moving a block body to a proper position by moving a first adjusting rod, screwing a bolt into a screw hole of a first fixing column, fixing the first adjusting rod, opening the mouth of the mouse to bite the block body, moving a head clamping piece to a proper position by moving a second adjusting rod, enabling two head clamping pieces to be attached to each other, thereby clamping the head of the mouse, screwing the bolt into a screw hole of a second fixing column, fixing the second adjusting rod, fixing the body of the mouse through a body fixing piece, after the fixing is finished, controlling a first electric telescopic rod to move to a proper position by a controller, adjusting the height, injecting an injection medicament into an injection tube after the adjustment is finished, controlling a rotating motor to rotate by the controller, further driving a threaded rod to rotate, enabling a threaded block to rotate, driving a limiting block to slide along the limiting rod, and then drive the dead lever and move down, and then drive first piston and move down for the injection medicament of injection tube pours into the mouse stomach through the gavage needle, and the controller acquires the information of electronic scale in real time, according to electronic scale data before the injection and the electronic scale data after the injection, can obtain the weight of injection medicament, can realize automatic accurate gavage and administer the medicine.

As shown in fig. 3, a medicine inlet is arranged at the top of the medicine bin 43, the medicine inlet is connected with a medicine inlet pipe 44 for inputting medicine liquid, an electromagnetic valve is arranged on the medicine inlet pipe 44, a medicine outlet is arranged at the bottom of the medicine bin 43, the medicine outlet is connected with a first end of the T-shaped pipe, a second end of the T-shaped pipe is connected with an upper chamber 41 positioned at the lower side of the second piston 47, a third end of the T-shaped pipe is suspended for accessing an external water source for cleaning, the electromagnetic valve 45 is arranged at the first end, the second end and the third end of the T-shaped pipe, the injection part comprises an injection needle 49 and a needle tube 48, the upper chamber 41 positioned at the lower side of the second piston 47 is connected with the needle tube 48, the needle tube 48 is connected with the injection needle 49, the electromagnetic valve 45 is arranged on the needle tube 48, the electromagnetic valve 45 is electrically connected with the controller 7, and the connection part of the second electric telescopic rod 46 and the partition plate 50 adopts mechanical seal, the second piston 47 is provided with an elastic sealing layer at the joint with the upper chamber 41, the drug chamber 43 and the injection box 40 are made of transparent materials, and the drug chamber 43 and the injection box 40 corresponding to the upper chamber 41 are provided with scale marks on the outer parts;

the work flow of the injection dosing module is as follows: the mouse is fixedly arranged on a mouse fixing piece, wherein the fixing mode is the same as the mode of the automatic intragastric perfusion administration module, the mouse can be injected without the operation of an opening component, after the fixation is finished, firstly, the controller controls the electromagnetic valve of the medicine inlet pipe to be opened, the medicine liquid is injected into the medicine bin, the electromagnetic valve of the medicine inlet pipe is closed after the injection is finished, the electromagnetic valves of the first end and the second end of the T-shaped pipe of the controller are opened, the second electric telescopic rod is controlled to move upwards after the electromagnetic valves are opened, the second piston is driven to move upwards, the medicine liquid in the medicine bin is sucked into the upper cavity, after the medicine liquid is judged to be enough sucked according to the scale mark of the medicine bin or the upper cavity, the controller controls the electromagnetic valves of the first end and the second end of the T-shaped pipe to be closed, the electromagnetic valves of the needle pipe are controlled to be opened, the injection is carried out, the injector is pricked into the body of the mouse, and the controller controls the second electric telescopic rod to move downwards, and then the liquid medicine in the upper cavity is pressed into the injector and injected into a mouse body, the injection dosage can be judged according to the scale mark of the upper cavity, and also can be judged according to the numerical difference before and after injection by the electronic scale, after the injection is finished, the electromagnetic valves of the second end and the third end of the T-shaped pipe and the electromagnetic valve of the needle tube can be opened, and clean water is introduced from the third end of the T-shaped pipe to clean the upper cavity and the injection part.

As shown in fig. 4, the shaking and containing device comprises a supporting plate 13, baffle plates 11, third electric telescopic rods 14 and a supporting rod 12, wherein the supporting rod 12 is arranged at the front side and the rear side inside the box body 10 through a rotating part, the supporting rod 12 penetrates through the supporting plate 13 to rotatably arrange the supporting plate 13 inside the box body 10, two third electric telescopic rods 14 are arranged at the bottom inside the box body 10, the output ends of the two third electric telescopic rods 14 are respectively and fixedly connected with the bottom of the supporting plate 13, four baffle plates 11 are arranged at the top of the supporting plate 13, and a placing cavity is defined by the baffle plates 11 and the supporting plate 13 and used for placing a mouse;

the work flow of the atomization inhalation administration module is as follows: open the upper cover, place the mouse and place the intracavity, place the back that finishes, close the upper cover, temperature sensor gathers the temperature in the box in real time, if the temperature crosses lowly, then controller control heater heats, keep stable experiment temperature, controller control atomization host computer is opened, carry the atomizing medicine for the box in through the spray tube, every dead time, the controller rocks with regard to control and holds the device and open, specifically do, the third electric telescopic handle non-simultaneous flexible on control left side and right side, and then make the backup pad rotate around the bracing piece, make the mouse can not embrace the group and prick heap or sleep, improve the precision of experimental data, wherein, rotatory number of degrees is as little as possible, prevent that the mouse from placing the intracavity and dropping.

As shown in fig. 1, the fixed support includes a first fixed plate 4, a second fixed plate 5 and a fourth electric telescopic rod 6, four fourth electric telescopic rods 6 and a controller 7 are arranged at the top of the first fixed plate 4, the second fixed plate 5 is fixedly arranged at the output end of the fourth electric telescopic rod 6, the automatic intragastric perfusion drug delivery module 1, the injection drug delivery module 2 and the aerosol inhalation drug delivery module 3 are fixedly arranged at the top of the second fixed plate 5, the fourth electric telescopic rod 6 is electrically connected to the controller 7, and a universal wheel 8 and a brake pad are arranged at the bottom of the first fixed plate 4 for realizing the movement and fixation of the device;

according to the demand, the controller 7 can control the fourth electric telescopic rod 6 to synchronously stretch, so that the second fixing plate 5 moves up or down to be adjusted, and the universal wheel 8 and the brake pad are used for moving or fixing the device.

The device still can set up wireless communication module and touch-sensitive screen, and wherein touch-sensitive screen electric connection the controller, the controller passes through wireless communication module communication connection host computer or removes the end, can send information to host computer or remove the end, and the accessible touch-sensitive screen controls the controller to and look over the information that the controller obtained, wherein the touch-sensitive screen can set up on the second fixed plate.

The intelligent control drug delivery device for the experimental mouse is provided with the automatic gavage drug delivery module, can realize gavage drug delivery of the mouse in the experimental process, fixes the mouse through the mouse fixing piece, opens the mouth of the mouse, and performs gavage drug delivery on the mouse through the lifting gavage mechanism, can determine the weight of liquid medicine to be filled in real time through the electronic scale, can realize accurate automatic control gavage drug delivery, and is simple and convenient; the device is provided with an injection dosing module, so that injection dosing can be performed on a mouse in an experimental process, the mouse is fixed on a mouse fixing piece, when the device is used, a controller controls a second electric telescopic rod to move upwards, liquid medicine in a medicine bin is sucked into an injection box, then the second electric telescopic rod is controlled to move downwards, the liquid medicine in the injection box is injected into the mouse body through an injection part, and accurate injection can be realized according to scales on the medicine bin and the injection box and weighing of an electronic scale; the device still is provided with the aerosol inhalation module of dosing, can realize the aerosol inhalation and dose, place the mouse during use and hold on the device rocking, can rock through the device, prevent that the mouse from holding a group and prick the heap, perhaps some mice are in the sleep state and another part is in the waking state, and then make the inspiratory dose of mouse between the individual relatively even, make experimental data more accurate, temperature sensor can the internal temperature of real-time detection box, when the temperature is low excessively, controller control heater begins, the going on of assurance experiment, improve the experiment accuracy.

The principles and embodiments of the present invention have been described herein using specific examples, which are provided only to help understand the method and the core concept of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.

Claims

1. The utility model provides an experimental mice is with intelligent control device of dosing which characterized in that includes: the automatic intragastric administration device comprises an automatic intragastric administration module, an injection administration module, an aerosol inhalation administration module, a fixed support and a controller, wherein the automatic intragastric administration module, the injection administration module, the aerosol inhalation administration module and the controller are fixedly arranged at the top of the fixed support, and the automatic intragastric administration module, the injection administration module and the aerosol inhalation administration module are electrically connected with the controller;

2. The intelligent control drug delivery device for experimental mice as claimed in claim 1, wherein the elevating gastric perfusion mechanism comprises a top plate, a limit rod, a threaded rod, an L-shaped bracket, a rotating motor, a fixed rod, a syringe, a one-way valve and a gastric perfusion needle, the top plate is fixedly arranged at the top of the first electric telescopic rod, the rotating motor, the limit rod and the L-shaped bracket are fixedly arranged at the bottom of the top plate, the limit rod is arranged at the left side of the rotating motor, the L-shaped bracket is arranged at the right side of the rotating motor, the syringe is fixedly arranged on the L-shaped bracket, the syringe is connected with the gastric perfusion needle through the one-way valve, the position of the gastric perfusion needle corresponds to the position of the mouse fixing member, the threaded rod is fixedly arranged at the output end of the rotating motor, and a threaded block is connected to the threaded rod through a thread, the injection tube is characterized in that a limiting block is connected to the limiting rod in a sliding mode, the thread block is connected with the limiting block through a connecting rod, a fixing rod is connected to the left side of the limiting block, a first piston is fixedly arranged on the fixing rod and arranged inside the injection tube, and the rotating motor is electrically connected with the controller.

3. The intelligent control drug delivery device for the experimental mouse as claimed in claim 2, wherein the mouse fixing member comprises a vertical fixing plate, a head fixing member, an opening assembly and a body fixing member, the vertical fixing plate is fixedly arranged at the center of the top of the electronic scale, and the opening assembly, the head fixing member and the body fixing member are sequentially arranged on the front surface of the vertical fixing plate from top to bottom;

the head fixing piece is provided with two groups which are respectively arranged at the left side and the right side of the lower side of the opening assembly, the head fixing piece comprises a second fixing column, a second adjusting rod and a head clamping piece, the second fixing column is fixedly arranged at one side of the front side of the vertical fixing plate, a through hole is formed in the side surface of the second fixing column, the second adjusting rod penetrates through the through hole to be connected with the head clamping piece and is used for driving the head clamping piece to move left and right, and a screw hole is formed in the front side of the second fixing column and is used for allowing a bolt to penetrate through to fix the second adjusting rod;

4. The intelligent control drug delivery device for experimental mice as claimed in claim 1, wherein a drug inlet is arranged at the top of the drug bin, the drug inlet is connected with a drug inlet tube for inputting drug liquid, an electromagnetic valve is arranged on the drug inlet tube, a drug outlet is arranged at the bottom of the drug bin, the drug outlet is connected with the first end of the T-shaped tube, the second end of the T-shaped tube is connected with the upper chamber at the lower side of the second piston, the third end of the T-shaped tube is suspended and used for accessing an external water source for cleaning, the electromagnetic valves are arranged at the first end, the second end and the third end of the T-shaped tube, the injection part comprises an injection needle and a needle tube, the upper chamber at the lower side of the second piston is connected with the injection needle, the needle tube is connected with the injection needle, the electromagnetic valve is arranged on the needle tube, and the electromagnetic valve is electrically connected with the controller, the second electric telescopic handle with the junction of baffle adopts mechanical seal for prevent that the liquid medicine from flowing into the cavity of resorption, the second piston with the junction of epicoele is provided with the elastic sealing layer, medicine storehouse and injection box all adopt transparent material, just medicine storehouse and with the outside of the corresponding injection box of epicoele all is provided with the scale mark.

5. The intelligent control drug delivery device for the experimental mouse as claimed in claim 1, wherein the shaking and containing device comprises a support plate, baffles, third electric telescopic rods and support rods, the support rods are arranged on the front side and the rear side of the interior of the box body through rotating pieces, the support rods penetrate through the support plate to rotatably arrange the support plate in the box body, two third electric telescopic rods are arranged at the bottom of the interior of the box body, the output ends of the two third electric telescopic rods are respectively and fixedly connected with the bottom of the support plate, four baffles are arranged at the top of the support plate, and a placing cavity is defined by the baffles and the support plate and used for placing the mouse.

6. The intelligent control drug delivery device for the experimental mouse as claimed in claim 1, wherein the fixing support comprises a first fixing plate, a second fixing plate and a fourth electric telescopic rod, four fourth electric telescopic rods and a controller are arranged at the top of the first fixing plate, the second fixing plate is fixedly arranged at the output end of the fourth electric telescopic rod, the automatic intragastric perfusion drug delivery module, the injection drug delivery module and the atomization inhalation drug delivery module are fixedly arranged at the top of the second fixing plate, the fourth electric telescopic rod is electrically connected with the controller, and a universal wheel and a brake pad are arranged at the bottom of the first fixing plate and used for achieving movement and fixation of the device.