CN114668958A

CN114668958A - Medicine balloon catheter with blood blocking and plaque cutting functions

Info

Publication number: CN114668958A
Application number: CN202210202644.3A
Authority: CN
Inventors: 杜瑞林; 毛建辉
Original assignee: Hangzhou Barty Medical Technology Co ltd
Current assignee: Hangzhou Barty Medical Technology Co ltd
Priority date: 2022-03-03
Filing date: 2022-03-03
Publication date: 2022-06-28

Abstract

The invention belongs to the technical field of cardiovascular interventional therapy, and particularly relates to a medicinal balloon catheter with blood blocking and plaque cutting functions. The invention achieves the purposes of blocking the blood before medicine is applied to the inner wall of the blood vessel by the medicine saccule and cutting the plaque by arranging the rear support saccule unit, the front blocking saccule unit, the guide wire for traction and the combined three-tube unit on the three-tube unit. The invention has the following advantages: firstly, in the three-cavity tube unit, one cavity is used for installing a guide wire, the other cavity is used for expanding a rear support balloon unit, and the last cavity is used for plugging the balloon unit before expansion, so that the three actions are independent and do not influence each other; secondly, the surface of the rear support balloon unit is coated with the medicine, and the medicine balloon unit is always folded before and during insertion of the medicine balloon catheter, so that the washing and the loss of the medicine by blood are reduced.

Description

Medicine balloon catheter with blood blocking and plaque cutting functions

Technical Field

The invention belongs to the technical field of cardiovascular interventional therapy, and particularly relates to a medicinal balloon catheter with blood blocking and plaque cutting functions.

Background

Vascular diseases such as vascular calcification, atherosclerosis, etc., typically involve narrowing of the inner diameter of the vessel, and vascular intervention is required to open the previously obstructed vessel. Vascular interventional procedures have also undergone successive generations of techniques with progressive optimization as neuroimaging, catheter techniques and materials, computers, and other sciences have progressed rapidly.

1. Balloon catheter intervention

A balloon catheter is a common tool for angioplasty, and is used for introducing a balloon into a stenosed portion of a blood vessel through a guide wire and a guide catheter, and expanding the balloon with pressure to lyse plaque, thereby finally expanding the blood vessel and improving blood flow. However, in 30-40% of patients after surgery, the vessels become stenotic again due to many reasons including damage to the vascular endothelium, hyperproliferation of smooth muscle cells, and lack of support for the dilated vessels.

2. Vascular stent treatment

This technique consists in fitting a metal mesh stent outside the balloon, delivering the stent to the lesion, still via a balloon catheter, and permanently embedding the stent in the intima of the coronary artery of the patient after expansion of the balloon. However, in this way, the blood vessels of 10-20% of patients are still subject to smooth muscle proliferation due to the immune response of the human body, which eventually causes the blood vessels to become stenotic again after the stent is expanded.

Since the stent has been permanently embedded in the intima of the patient's coronary artery, it has not been possible to remove the implanted stent and perform a re-stenting procedure.

3. Drug-loaded stent technology

In order to solve the problem of restenosis of blood vessels caused by stent implantation, a drug-loaded stent is rapidly becoming a main means of cardiovascular stent implantation treatment technology in recent years. Because the surface of the metal stent is coated with a layer of medicine for inhibiting the growth of smooth muscle, the restenosis rate of the blood vessel of a patient after the operation can be reduced to below 5 percent.

But compared with the common naked stent without drug loading, the drug-loaded stent is very expensive, and the high molecular material on the drug-loaded coating can also cause some patients to generate thrombus, thus finally causing serious adverse reaction.

4. Drug balloon catheter technology

Therefore, the balloon catheter with the drug coating is produced, compared with a drug-loaded stent, the balloon catheter with the drug coating has drugs for inhibiting the growth of smooth muscles, but does not need to be coated with a high polymer material, so serious adverse reactions such as thrombus and the like can not be caused.

The balloon catheter is characterized in that the outer surface of the balloon is coated with a medicament with a treatment effect, when the balloon reaches a diseased part in a blood vessel, the balloon is expanded to enable the medicament coating on the surface of the balloon to be in contact with the inner wall of the blood vessel, and the medicament is released and acts on the diseased part, so that the aim of treating and preventing restenosis in the blood vessel is fulfilled. This allows for a second treatment even if the patient's blood vessel becomes stenotic and occluded.

For example, the Chinese utility model patent with patent publication No. CN205831969U and publication No. 2016.12.28 discloses an interventional therapy inner stent drug balloon, which comprises a catheter group, a self-expanding stent and a balloon; the guide pipe group comprises a sleeve pipe, an outer pipe and an inner pipe; the stent comprises a main body, a proximal end part and a distal end part; the inner tube penetrates into the bracket from the near end part and extends to converge and be fixedly connected with the far end part, and the near end part is sleeved on the outer wall of the inner tube in a sliding manner; the support is located the sacculus, and sacculus one end rigid coupling is in outer tube and inside and the inside intercommunication each other of outer tube of sacculus, and the other end is in the same place with support distal end portion and inner tube rigid coupling.

The utility model discloses a support medicine sacculus in the patent can realize the effect of most basic medicine sacculus pipe technique, but in the use, still has following two problems at least:

firstly, when the saccule enters a blood vessel, the medicine on the saccule can rub with the blood vessel wall, and further fall off greatly;

secondly, when the balloon enters the blood vessel, the medicine on the balloon can be washed by the blood, and a large amount of medicine is lost, so that the medicine cannot reach the lesion site.

Therefore, in view of the above, there is an urgent need for a new drug balloon catheter device with an improved structure, which ensures that the drug on the balloon reaches the diseased region of the blood vessel as much as possible.

Disclosure of Invention

The invention provides a medicine balloon catheter with blood blocking and plaque cutting functions, which can achieve the purposes of blood blocking and plaque cutting before medicine is applied to the inner wall of a blood vessel by a medicine balloon in a mode of arranging a rear support balloon unit, a front blocking balloon unit, a guide wire for traction and a combined three-tube unit on a three-cavity tube unit.

The technical scheme adopted by the invention for solving the problems is as follows: a medicine balloon catheter with blood blocking and plaque cutting functions comprises a three-cavity tube unit, a rear support balloon unit, a front plugging balloon unit, a traction guide wire and a combined three-tube unit, wherein the rear support balloon unit is arranged on the three-cavity tube unit and used for performing plaque cutting and medicine smearing operations on a blood vessel pathological change part, the front plugging balloon unit is arranged on the three-cavity tube unit and used for blocking blood before the rear support balloon unit is unfolded, the traction guide wire is arranged in the three-cavity tube unit, and the combined three-tube unit is arranged at the insertion rear end of the three-cavity tube unit and used for performing inflation and decompression operations on the rear support balloon unit and the front plugging balloon unit and performing insertion and installation operations on the traction guide wire.

The further preferred technical scheme is as follows: the three-cavity tube unit comprises a tube wire, a guide wire through hole arranged in the tube wire, a treatment pore channel arranged in the tube wire and used for carrying out pressure charging and releasing operation on the rear support balloon unit, a plugging pore channel arranged in the tube wire and used for carrying out pressure charging and releasing operation on the front plugging balloon unit, a rear end hole arranged on the treatment pore channel and a front end hole arranged on the plugging pore channel.

The further preferred technical scheme is as follows: the rear support balloon unit comprises a non-compliant balloon with two closed ends, a drug layer arranged on the outer surface of the non-compliant balloon, a metal support sleeved on the outer side of the non-compliant balloon, and two drug marking rings which are arranged on the wire and are respectively positioned at the positions of two sides of the rear end hole.

The further preferred technical scheme is as follows: the front plugging balloon unit comprises a compliance balloon which is sleeved on the wire rod for the tube, covers the front end hole and is sealed at two ends, and a plugging marking ring arranged on the wire rod for the tube.

The further preferred technical scheme is as follows: the three-cavity tube unit also comprises an inner tube which is arranged in the guide wire through hole and is used for installing the medicine marking ring and the plugging marking ring.

The further preferred technical scheme is as follows: the combined three-tube unit comprises a middle tube body, a first side tube and a second side tube, wherein the middle tube body is butted with the guide wire through hole and is used for inserting the traction guide wire, the first side tube is arranged on the middle tube body and is butted with the treatment hole channel, and the second side tube is arranged on the middle tube body and is butted with the plugging hole channel.

The further preferred technical scheme is as follows: the three lumen unit further includes an insertion tip disposed on the tube wire, and a middle guidewire hole disposed within the insertion tip.

The further preferred technical scheme is as follows: the aperture of the middle wire guide hole is smaller than that of the wire guide through hole.

The further preferred technical scheme is as follows: the front plugging balloon unit further comprises two assembling press rings which are respectively arranged at two ends of the compliance balloon and used for embedding the wire for the tube.

The further preferred technical scheme is as follows: and a three-cavity connecting hose is further arranged between the middle pipe body and the wire for the pipe.

The present invention has the following advantages.

First, in the three-cavity tube unit, one cavity is used for installing a guide wire, the other cavity is used for expanding a rear support balloon unit, and the last cavity is used for plugging the balloon unit before expansion, so that the three actions are mutually independent and mutually independent.

Secondly, the surface of the rear bracket balloon unit is coated with a medicine, and the medicine balloon unit is folded before and during insertion of the medicine balloon catheter, so that the washing and the loss of the medicine by blood are reduced.

And thirdly, before the rear support balloon unit is opened, the front plugging balloon unit is firstly opened to be used for blocking blood upstream, so that the medicine on the rear support balloon unit is enabled to be transferred to a lesion part as much as possible, and the medicine utilization rate is improved.

Fourth, the back support sacculus unit includes ordinary support, and it can imbed, cut the plaque when expanding to open, guarantees that the medicine takes effect sooner, and the effect is better.

Fifthly, the rear support balloon unit and the front plugging balloon unit are provided with marking structures, so that the insertion action of the medicine balloon catheter is more accurate, and the rear support balloon unit is sufficiently aligned with a lesion part.

Sixthly, the rear support balloon unit and the front plugging balloon unit are convenient to pressurize and decompress, and the medicine balloon catheter is guaranteed to be convenient to withdraw.

Seventhly, the specific structure of the whole drug balloon catheter is stable enough, the operation is relatively comfortable and convenient, and the drug balloon catheter is suitable for various cardiovascular diseases.

Drawings

FIG. 1 is a schematic structural diagram of the present invention.

FIG. 2 is a schematic diagram of the position structure of the triple lumen tube unit of the present invention.

Fig. 3 is a schematic view of the position structure of the inner tube in the present invention.

Fig. 4 is a schematic view of the position structure of the combined triple tube unit of the present invention.

Fig. 5 is a schematic view showing the installation position of the pressure ring according to the present invention.

FIG. 6 is a schematic view of the position structure of the three-cavity connection hose of the present invention.

In the drawings, the reference numerals denote the following components: the three-cavity tube unit 1, the rear support balloon unit 2, the front plugging balloon unit 3, the guide wire 4 for traction, the combined three-tube unit 5, the tube wire 101, the guide wire through hole 102, the therapeutic pore 103, the plugging pore 104, the rear end hole 105, the front end hole 106, the non-compliant balloon 201, the metal stent 202, the drug marking ring 203, the compliant balloon 301, the plugging marking ring 302, the inner tube 107, the middle tube body 501, the first side tube 502, the second side tube 503, the insertion tip 108, the middle guide wire hole 109, the assembling press ring 303 and the three-cavity connecting hose 6.

Detailed Description

The following description is merely exemplary of the present invention and is not intended to limit the scope of the invention.

As shown in fig. 1-6, a medical balloon catheter with blood blocking and plaque cutting functions comprises a three-lumen unit 1, a rear stent balloon unit 2 arranged on the three-lumen unit 1 and used for performing plaque cutting and drug smearing operations on a blood vessel lesion part, a front occlusion balloon unit 3 arranged on the three-lumen unit 1 and used for blocking blood before the rear stent balloon unit 2 is unfolded, a traction guide wire 4 arranged in the three-lumen unit 1, and a combined three-lumen unit 5 arranged at the insertion rear end of the three-lumen unit 1 and used for performing inflation and decompression operations on the rear stent balloon unit 2 and the front occlusion balloon unit 3 and performing insertion and installation operations on the traction guide wire 4.

In this embodiment, the method for producing the drug balloon catheter generally comprises the following steps.

Firstly, the three-cavity structure of the three-cavity tube unit 1 is self-contained, holes are firstly needed to be punched on the three-cavity tube, and the rear support balloon unit 2 and the front plugging balloon unit 3 are guaranteed to be inflated and decompressed and reduced at corresponding punching positions.

Secondly, drugs are dipped or ultrasonically sprayed on the surface of the balloon of the rear support balloon unit 2.

Thirdly, the stent of the rear stent balloon unit 2 is arranged on the outer annular surface of the three-cavity tube unit 1 in a laser welding mode.

Fourthly, necessary marking structures of the rear bracket balloon unit 2 and the front plugging balloon unit 3 are installed, and the position of the medicine balloon catheter can be checked and controlled after the medicine balloon catheter enters a blood vessel.

Fifthly, installing respective balloons of the rear support balloon unit 2 and the front plugging balloon unit 3 on the outer annular surface of the three-cavity tube unit 1.

And finally, correspondingly connecting the combined three-cavity tube unit 5 and the three-cavity tube unit 1 to ensure that the basic functions of 'two-cavity charging and pressure relief and one-cavity guide wire penetration' are effective.

The three-lumen tube unit 1 includes a tube wire 101, a guide wire through hole 102 provided in the tube wire 101, a therapeutic pore passage 103 provided in the tube wire 101 and used for performing inflation and deflation operations on the rear stent balloon unit 2, a plugging pore passage 104 provided in the tube wire 101 and used for performing inflation and deflation operations on the front plugging balloon unit 3, a rear end hole 105 provided in the therapeutic pore passage 103, and a front end hole 106 provided in the plugging pore passage 104.

In this embodiment, the material of the tube wire 101 may be conventional medical grade stainless steel or safe resin, the guide wire through hole 102 is located in the center of the circle of the tube wire 101, and the therapeutic duct 103 and the occlusion duct 104 are located on both sides of the circle, which are separated as much as possible.

The guide wire insertion hole 102 is opened at both ends, and the therapeutic tunnel 103 and the occlusion tunnel 104 are opened to an appropriate depth from the connection end of the tube wire 101 and the combined triple tube unit 5, for example: the opening depth of the therapeutic hole 103 is 80% of the length of the wire 101 for a tube, and the opening depth of the plugging hole 104 is 95% of the length of the wire 101 for a tube.

Finally, the rear end hole 105 is completely covered by the balloon of the rear stent balloon unit 2, and the front end hole 106 is completely covered by the balloon of the front occlusion balloon unit 3, so that the expansion and contraction actions of the two balloons are effective and independent of each other.

The rear stent balloon unit 2 comprises a non-compliant balloon 201 with two closed ends, a drug layer arranged on the outer surface of the non-compliant balloon 201, a rear stent balloon unit 2 sleeved on the wire 101 for the tube and covering the rear end hole 105, a metal stent 202 with two ends fixedly connected with the wire 101 for the tube, and two drug marking rings 203 arranged on the wire 101 for the tube and respectively positioned at two side positions of the rear end hole 105, wherein the drug layer is sleeved on the outer surface of the non-compliant balloon 201 and sleeved outside the non-compliant balloon 201.

In this embodiment, the non-compliant balloon 201 means that the balloon does not increase after being pressed to a certain pressure, and is a common balloon used in the current vascular intervention operation, and both ends of the balloon are laser-welded to the outer circumferential surface of the tube wire 101, and the material of the balloon is PA or Pebax.

In addition, the medicine layer is of a microcrystalline structure, the main medicine body of the medicine layer is made of immunosuppressants such as rapamycin and paclitaxel, and the medicine layer further comprises organic solvents such as isopropanol and acetonitrile. After the medicine layer is coated, the non-compliance balloon 201 is folded into a plurality of pieces by a balloon folding machine and is wound together, so that the medicine cannot be largely washed out by blood and fall off when the medicine balloon catheter is added into a blood vessel.

The metal stent 202 is made of a conventional and common nickel-titanium alloy with memory performance, two ends of the nickel-titanium alloy are respectively welded to the outer annular surface of the wire 101 for the tube, the non-compliant balloon 201 is expanded, so that the metal stent 202 can be unfolded, and finally, the function of extruding and cutting the calcified plaque of the blood vessel is realized, the vascular plaque is deformed and the surface area is increased by the extrusion, the medicine feeding efficiency is improved, and the cutting action is more upgraded than the extrusion action.

The front occlusion balloon unit 3 includes a compliant balloon 301 that is fitted over the tube wire 101, covers the front end hole 106, and has both ends closed, and an occlusion marker ring 302 provided on the tube wire 101.

In this embodiment, the plugging mark ring 302 and the drug mark ring 203 are made of the same material, and mainly made of polymeric plastic, and Wu, Ba, Bi, etc. are used as X-ray developing components, so as to ensure the insertion speed and depth of the drug balloon catheter, and be checked and controlled under the guidance of X-ray. The plugging mark ring 302 and the medicine mark ring 203 are pressed and fixed to the outer circumferential surface of the pipe string 101 by an existing press-grip machine.

In addition, the compliance balloon 301 is within a certain pressure value range, and the larger the inflation pressure of the front end hole 106 is, the larger the inflation volume thereof is, so that when the medicine balloon catheter is in place, namely the blood vessel plaque is located between the two medicine marking rings 203, the compliance balloon 301 can be fully inflated firstly, and the blood is blocked at the upstream of the blood vessel, so that the medicine layer is prevented from being largely washed and lost by the blood in the unfolding process.

Finally, the compliant balloon 301 is made of latex or silica gel, and both ends of the compliant balloon are sealed and fixed on the outer annular surface of the tube-use wire 101 by means of wire binding and metal ring fixation.

The triple lumen unit 1 further comprises an inner tube 107 disposed in the guide wire through hole 102 and used for installing the drug marking ring 203 and the occlusion marking ring 302.

In this embodiment, the drug marker ring 203 and the occlusion marker ring 302 can be installed in two different optional ways.

First, the method of installing the outer circumferential surface of the wire 101 for a tube and the inner side of the corresponding balloon has advantages in that the inner tube 107 can be omitted, and there is a disadvantage in that if the marker ring is embedded in the outer circumferential surface of the wire 101 for a tube, the structural strength of the wire 101 for a tube is reduced, and if it is not embedded, it is protruded itself, and the two balloons and the metal stent 202 cannot be completely converged to fit the outer circumferential surface of the wire 101 for a tube.

Secondly, as mentioned above, the marker rings are arranged on both the outer and inner annular surfaces of the inner tube 107, but the disadvantage of the first method is not present, but there is one more structure of the inner tube 107, and the traction guide wire 4 needs to pass through the inner tube, so that the structural complexity and diameter of the whole medical balloon catheter are increased.

Finally, in order to match the insertion and installation actions of the inner tube 107, the guide wire through hole 102 may be provided with a reduced "step" at the front end to ensure that the inner tube 107 has a fixed insertion end point, so that the positions of the drug marking ring 203 and the occlusion marking ring 302 are well positioned.

The combined triple tube unit 5 includes a middle tube 501 abutting the guide wire through hole 102 and into which the traction guide wire 4 is inserted, a first side tube 502 provided on the middle tube 501 and abutting the therapeutic hole 103, and a second side tube 503 provided on the middle tube 501 and abutting the occlusion hole 104.

In this embodiment, the material of the combined triple tube unit 5 may be medical grade PP resin, so as to ensure proper hardness. The orifices of the first lateral tube 502 and the second lateral tube 503 are respectively connected with the physiological saline or the contrast agent for pressurizing, so as to ensure that the non-compliance balloon 201 and the compliance balloon 301 corresponding to each other are controllably expanded and contracted.

The three lumen unit 1 further comprises an insertion tip 108 disposed on the tube wire 101, and a middle guide wire hole 109 disposed in the insertion tip 108.

In this embodiment, the insertion tip 108 and the tube wire 101 may be welded later or integrally formed from the beginning, and the traction guide wire 4 sequentially passes through the middle tube 501, the guide wire through hole 102, and the middle guide wire hole 109, and protrudes at the front end, so that the traction effect can be achieved during the insertion of the balloon catheter.

The diameter of the middle wire hole 109 is smaller than that of the wire through hole 102.

In this embodiment, the diameter of the middle wire hole 109 is smaller than that of the wire through hole 102, i.e. the above-mentioned "step" structure is formed, so as to ensure that the insertion of the inner tube 107 has a fixed end point.

The most advantageous of this arrangement is that the positions of the drug marking ring 203 and the occlusion marking ring 302 on the inner tube 107, that is, the positions of the marking rings on the tube wire 101, do not need to be converted.

The front occlusion balloon unit 3 further includes two fitting rings 303 respectively provided at both ends of the compliant balloon 301 and used to fit the tube wire 101.

In this embodiment, the assembling press ring 303 is an installing ring of the compliant balloon 301, so as to ensure that two ends of the compliant balloon 301 are fixed firmly and sealed sufficiently.

And a three-cavity connecting hose 6 is arranged between the middle pipe body 501 and the pipe wire 101.

In this embodiment, the drawing guide wire 4 can be inserted into the blood vessel after being installed in the balloon catheter, and the three-lumen connecting tube 6, which is relatively soft, can be used to ensure the effective charging and discharging of the saline or contrast agent since the three-lumen unit 5 and the tube wire 101 do not need to be aligned.

And the three-cavity connecting hose 6 is added, so that the original hard-hard connection mode of the wire 101 for the pipe and the combined three-pipe unit 5 is improved into hard-soft-hard connection, and the three-cavity connecting hose is more convenient and has higher sealing performance.

Finally, the general method of use and advantages of the drug balloon catheter are as follows.

First, the pull guidewire 4 is extended over the insertion tip 108 to complete the pre-use installation procedure of the drug balloon catheter.

Second, a drug balloon catheter is inserted into the vessel under X-ray monitoring until the vascular lesion comes between the two drug marker rings 203.

Thirdly, the second lateral tube 503 is pressurized to expand the compliant balloon 301, so as to block the blood vessel and reduce the blood flow speed.

Fourthly, the second side tube 503 is held, and then the first side tube 502 is pressurized to expand the non-compliant balloon 201 and indirectly expand the metal stent 202, so as to compress and divide the blood vessel plaque, and completely release the medicine on the surface of the non-compliant balloon 201 to the blood vessel lesion.

Fifthly, the second side tube 503 is firstly decompressed, then the second side tube 503 is decompressed, and the whole medicine balloon catheter returns to the initial state and finally is withdrawn.

The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various modifications can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. These are non-inventive modifications, which are intended to be protected by patent laws within the scope of the claims appended hereto.

Claims

1. A medicine balloon catheter with blood blocking and plaque cutting functions is characterized in that: including three lumen tube unit (1), set up on three lumen tube unit (1) for back support sacculus unit (2) of operation is paintd to plaque cutting, medicine are carried out at vascular pathological change position sets up three lumen tube unit (1) is last, and be used for blockking preceding shutoff sacculus unit (3) of blood before back support sacculus unit (2) expandes, set up and be in lead wire (4) for pulling in three lumen tube unit (1), and set up and be in three lumen tube unit (1) insert the rear end, and be used for right back support sacculus unit (2) and preceding shutoff sacculus unit (3) fill the pressure release operation, right it inserts three tub of unit (5) of combination of installation operation with lead wire (4) for pulling.

2. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 1, wherein: three lumen unit (1) are including using wire rod (101), set up guide wire through-hole (102) in using wire rod (101), set up in using wire rod (101), and be used for right after support sacculus unit (2) carry out the treatment of inflating and releasing pressure operation with pore (103), set up in using wire rod (101), and be used for right before shutoff sacculus unit (3) carry out the shutoff with pore (104) of inflating and releasing pressure operation, set up rear end hole (105) on the treatment with pore (103), and set up front end hole (106) on the pore (104) are used in the shutoff.

3. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 2, wherein: the rear stent balloon unit (2) comprises a wire (101) which is sleeved on the tube, covers the rear end hole (105), a non-compliant balloon (201) with two closed ends, a drug layer arranged on the outer surface of the non-compliant balloon (201), a non-compliant balloon (201) which is sleeved on the outer side, and two ends of the non-compliant balloon (201) are fixedly connected with a metal stent (202) of the wire (101) for the tube, and are arranged on the wire (101) for the tube, and are respectively positioned on two drug marking rings (203) at two side positions of the rear end hole (105).

4. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 3, wherein: the front plugging balloon unit (3) comprises a compliance balloon (301) which is sleeved on the wire (101) for the tube, covers the front end hole (106) and is closed at two ends, and a plugging marking ring (302) arranged on the wire (101) for the tube.

5. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 4, wherein: the three-cavity tube unit (1) further comprises an inner tube (107) which is arranged in the guide wire through hole (102) and is used for installing the medicine marking ring (203) and the blocking marking ring (302).

6. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 2, wherein: the combined three-tube unit (5) comprises a middle tube body (501) which is butted with the guide wire through hole (102) and is used for inserting the traction guide wire (4), a first side tube (502) which is arranged on the middle tube body (501) and is butted with the therapeutic hole channel (103), and a second side tube (503) which is arranged on the middle tube body (501) and is butted with the plugging hole channel (104).

7. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 2, wherein: the three-lumen tube unit (1) further includes an insertion tip (108) provided on the tube wire (101), and a middle guide wire hole (109) provided in the insertion tip (108).

8. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 7, wherein: the aperture of the middle wire guide hole (109) is smaller than that of the wire guide through hole (102).

9. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 4, wherein: the front plugging balloon unit (3) further comprises two assembling press rings (303) which are respectively arranged at two ends of the compliance balloon (301) and used for embedding the wire (101) for the tube.

10. The drug balloon catheter with the functions of blood blocking and plaque cutting as claimed in claim 6, wherein: and a three-cavity connecting hose (6) is further arranged between the middle pipe body (501) and the pipe wire (101).