CN114668546A

CN114668546A - Wrapping piece for administration of rat skin and application method thereof

Info

Publication number: CN114668546A
Application number: CN202210291158.3A
Authority: CN
Inventors: 倪睿; 彭宇; 李淑娟; 季芳
Original assignee: Chengdu Yaomingkant New Drug Development Co ltd
Current assignee: Chengdu Yaomingkant New Drug Development Co ltd
Priority date: 2022-03-23
Filing date: 2022-03-23
Publication date: 2022-06-28

Abstract

The invention discloses a wrapping piece for rat skin drug administration and a using method thereof. The wrapping piece for rat administration provided by the invention is simple in structure and beneficial to operation, can effectively prevent rats from licking administration parts in the administration process, can avoid the phenomenon of animal death in the traditional mode, and further improves the accuracy of experimental data of animal experiments; the application method of the wrapping piece for administration to rats, provided by the invention, is simple to operate, can ensure that animals can freely move in the administration process, and maximally conforms to the physiological characteristics and behavior characteristics of rats.

Description

Wrapping piece for administration of rat skin and application method thereof

Technical Field

The invention relates to the technical field of animal experiments, in particular to a wrapping piece for administration on rat skin and a using method thereof.

Background

With the development of science and technology, the types of the medicament formulations are gradually wide, different medicament formulations are suitable for different administration modes when various diseases are clinically treated, and doctors can select a reasonable administration mode according to the properties of medicaments and the treatment purpose.

Common routes of administration are oral, subcutaneous, intravenous, intramuscular, sublingual, rectal infusion, eye drops, nasal spray, oral inhalation and topical or systemic administration to the skin. Intravenous injection is one of the most common administration modes in clinic at present, has the characteristic of quick response, but also has complications such as phlebitis, pulmonary arteritis and the like caused by long-time transfusion, and can also cause dysbacteriosis in vivo; intramuscular injection is also a common mode, has the characteristics of accurate dosage and quick drug effect, but can cause hip muscle agglomeration, muscle contracture, even muscle atrophy, nerve injury and other hazards; the product of oral administration has more stable and convenient properties, but has the defects of slow effect taking and easy generation of first pass effect, namely, part of the medicine is administrated through gastrointestinal tracts and is metabolized at intestinal mucosa and liver before being absorbed and entering blood circulation, so that the original dosage entering the blood circulation is reduced; the sublingual administration has the characteristics of rapid absorption and high bioavailability, for example, the application of the misoprostol in the puerpera can achieve the purpose of preventing and treating postpartum hemorrhage by the sublingual buccal tablet form after the puerpera delivers a fetus, but the application range is relatively small.

The skin administration is an administration mode that the medicine is absorbed through the skin and enters the systemic blood system, and compared with the administration modes such as oral administration, subcutaneous injection and the like, the skin administration has the advantages of injection pain alleviation, first pass effect avoidance, stable and controllable blood concentration, good compliance and the like.

In animal experiments, rats are usually administered with a transdermal drug delivery in a pack. However, when the drug is applied to the skin, the therapeutic effect of the drug is easily limited by the absorption degree of the skin, and the common method for solving the problem is to wrap the skin application part. Traditional parcel piece and parcel method because the rat is comparatively nimble, leads to droing easily to influence the effect of dosing, nevertheless the parcel is too tight, leads to the activity of acceptor rat to receive obvious influence again easily, leads to the dead result of rat even, in addition, the tooth of rat grows for life and gnaws and stings the ability reinforce, when the parcel was dosed, still need to deal with the rat and gnaw and sting the scheduling problem of dosing device.

In summary, there is an urgent need in the art for a skin drug delivery pack and method of use thereof that meets the physiological and behavioral characteristics of rats and the actual skin drug delivery requirements, which can ensure the drug delivery effect of experimental animals and can also ensure the life safety and health of experimental animals.

Disclosure of Invention

In order to solve the technical problems, the invention provides a wrapping piece for rat skin administration and a using method thereof.

Specifically, the two fixing holes are correspondingly arranged on the left side and the right side of the body part respectively, and the two fixing holes are symmetrical to each other.

Specifically, the diameters of the two fixing holes are both 2 cm.

Specifically, the snap fastener comprises a sub-sticker and a mother sticker, the sub-sticker is arranged on the front side of the wrapping piece body, and the mother sticker is arranged on the back side of the wrapping piece body.

Specifically, the sub-paster comprises a plurality of fine soft fiber layers, and is a plurality of fine soft fiber layers are uniformly fixed on one side of the front surface of the wrapping part body at intervals, the main paster comprises a plurality of elastic fiber layers with hook thorns, and is a plurality of elastic fiber layers are uniformly fixed on one side of the back surface of the wrapping part body at intervals, the number of the fine soft fiber layers is consistent with the number of the elastic fiber layers, and the soft fiber layers correspond to the elastic fiber layers one to one in position.

Specifically, one side of the wrapping piece body, which is close to the fixing hole, is also provided with a wrapping edge.

Specifically, the wrapping body is made of elastic breathable flannelette.

The invention also provides a use method of the wrapping piece for rat skin administration, which comprises the following steps:

1) after skin administration is carried out on a rat, the fixing hole is sleeved on the forelimb of the rat, and meanwhile, the concave part corresponds to the abdominal cavity of the rat, so that the abdominal cavity of the rat is exposed and is not pressed by the wrapping piece body;

2) wrapping the wrapping piece body along the body of the rat so that the wrapping piece body completely wraps the body of the rat;

3) the son sticker and the mother sticker of the son-mother buckle are aligned and attached, so that the wrapping piece body is enabled to wrap the rat in a proper tightness.

Compared with the prior art, the invention has the beneficial effects that:

1. the wrapping piece for dosing the rat is simple in structure and convenient to operate, the fixing hole is matched with the position of the forelimb of the rat, the snap fastener is arranged to ensure that the wrapping piece is firm and does not fall off, and the wrapping edge is arranged to assist in weakening the uncomfortable feeling of the rat, so that the rat reduces gnawing and getting rid of actions on the wrapping piece, the effect of dosing the skin is better ensured, and the quality of experimental data is further improved;

2. according to the wrapping piece for rat administration, the wrapping piece is wrapped, so that the phenomenon that the drug effect is weakened due to the fact that a rat licks an administration part in the administration process or rubs off a drug can be effectively prevented, and the effect of improving the accuracy of experimental data is achieved;

3. the wrapping piece for rat drug administration provided by the invention adopts the elastic and breathable flannelette cloth, so that the discomfort degree of a rat in the drug administration process is reduced, the tightness is moderate, the rat is ensured not to die in the drug administration process, the animal death phenomenon in the traditional skin drug administration wrapping process is avoided, and the efficiency of animal experiments is further improved;

4. the application method of the wrapping piece for administration to the rat is simple to operate, can ensure that the animal freely moves in the administration process, and maximally accords with the physiological characteristics and behavior characteristics of the rat.

Drawings

FIG. 1 is a schematic front view of the wrapper body of the present invention;

FIG. 2 is a schematic view of the back side structure of the wrapper body of the present invention;

in the figure: 1. a wrapper body; 11. a body portion; 12. a concave portion; 2. a fixing hole; 3. a snap fastener; 31. sub-stickers; 32. mother plaster; 4. and (6) edge covering.

Detailed Description

The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Materials, instruments, reagents and the like used in the following examples are commercially available unless otherwise specified. The technical means used in the examples are conventional means well known to those skilled in the art, unless otherwise specified.

Example one

As shown in fig. 1-2, a wrapping piece for administration on rat skin comprises a wrapping piece body 1, wherein the wrapping piece body 1 is composed of a body part 11 and a concave part 12, two fixing holes 2 with the same size are formed in one side of the body part 11, the two fixing holes 2 are correspondingly formed in the left side and the right side of the body part 11 respectively, the two fixing holes 2 are symmetrical to each other, and the diameter of each fixing hole 2 is 2 cm. The fixing hole 2 is used for fixing the forelimb of the rat, the forelimb of the rat penetrates through the fixing hole 2, the mobility of the forelimb of the rat is adapted, the normal activity behavior of the rat is not affected, and therefore high quality and accuracy of experimental data are guaranteed.

The female part 12 is provided with a female hollowed-out part, the female part 12 being intended to receive the abdominal cavity of a rat. In the conventional rat wrapping method, the physiological characteristics of abdominal respiration of a rat are not noticed, the abdominal part of the rat is wrapped too tightly during wrapping, so that the rat respiration is influenced, the concave hollow-out part of the concave part 12 has enough space to accommodate the abdominal part of the rat, the respiration space of the rat is ensured, and the phenomenon that the rat dies in the experiment process is prevented. In the rat skin drug delivery package experiment, 178 experimental rats are arranged totally, 15 experimental rats die totally by adopting the traditional package piece and the packaging method, and no experimental rat dies when the package piece for rat skin drug delivery provided by the invention is used for packaging.

Wrap up one side of piece body 1 and be provided with snap fastener 3, wrap up piece body 1 and connect and wrap up the rat through snap fastener 3. The snap fastener 3 comprises a sub sticker 31 and a main sticker 32, wherein the sub sticker 31 is arranged on the front side of the wrapping piece body 1, and the main sticker 32 is arranged on the back side of the wrapping piece body 1. The sub-paster 31 comprises a plurality of fine soft fiber layers, the fine soft fiber layers are uniformly fixed on one side of the front face of the wrapping piece body 1 at intervals, the main paster 32 comprises a plurality of elastic fiber layers with hook thorns, the elastic fiber layers are uniformly fixed on one side of the back face of the wrapping piece body 1 at intervals, the number of the fine soft fiber layers is consistent with that of the elastic fiber layers, and the soft fiber layers correspond to the elastic fiber layers one to one in position. The setting of primary and secondary knot 3 for parcel piece body 1 can adapt to the rat of different size of body, and can make the fastening degree of parcel piece obtain promoting, thereby has improved the practicality of parcel piece.

One side of the wrapping piece body 1 close to the fixing hole 2 is also provided with a wrapping edge 4, and the wrapping piece body 1 is made of elastic and breathable flannelette materials. Bordure 4 and the setting of the ventilative cotton flannel material of elasticity, improved the travelling comfort of parcel piece, the daily activity of rat is unrestricted, and simultaneously when the rat activity, the parcel piece can not drop, and physiology and the action characteristics that accord with the rat of laminating rat health that can the at utmost have improved the practicality and the durable degree of parcel piece.

The application method of the wrapping piece for rat skin administration provided by the invention comprises the following steps:

1) after skin administration is carried out on a rat, the fixing hole 2 is sleeved on the forelimb of the rat, and meanwhile, the concave part 12 corresponds to the abdominal cavity of the rat, so that the abdominal cavity of the rat is exposed and is not pressed by the wrapping piece body 1;

2) wrapping the wrapping piece body 1 along the body of the rat so that the wrapping piece body 1 completely wraps the body of the rat;

3) the son sticker 31 and the mother sticker 32 of the son and mother buckle 3 are aligned and attached, so that the wrapping of the wrapping piece body 1 on the rat is ensured to be proper in tightness.

In conclusion, the wrapping piece for rat drug delivery provided by the invention is simple in structure and convenient to operate, better ensures the effect of skin drug delivery, and further improves the quality of experimental data; the drug effect can be effectively prevented from being weakened due to the fact that rats lick drug administration parts or rub drugs off in the drug administration process, the effect of improving the accuracy of experimental data is achieved, the phenomenon of animal death in the traditional skin drug administration wrapping process can be avoided, and the efficiency of animal experiments is further improved; the application method of the wrapping piece for administration to rats, provided by the invention, is simple to operate, can ensure that animals can move freely in the administration process, and maximally conforms to the physiological characteristics and behavior characteristics of rats.

In summary, the above embodiments are merely preferred embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. The utility model provides a rat skin is administered and is used parcel piece, includes parcel body (1), its characterized in that, parcel body (1) comprises this somatic part (11) and spill portion (12), two fixed orificess (2) that the size is the same are seted up to one side of this somatic part (11), fixed orifices (2) are used for the forelimb of fixed rat, spill portion (12) are provided with concave type fretwork portion, spill portion (12) are used for holding the abdominal cavity of rat, one side of parcel body (1) is provided with primary and secondary and detains (3), parcel body (1) are detained (3) through the primary and secondary and are connected and wrap up the rat.

2. The rat skin drug delivery pack according to claim 1, wherein two fixing holes (2) are provided on the left and right sides of the body part (11), respectively, and the two fixing holes (2) are symmetrical to each other.

3. The pack for rat skin administration according to claim 1, wherein both of the fixing holes (2) have a diameter of 2 cm.

4. The packaging for rat skin administration according to claim 1, wherein the snap fastener (3) comprises a sub-sticker (31) and a main sticker (32), the sub-sticker (31) is disposed on the front side of the packaging body (1), and the main sticker (32) is disposed on the back side of the packaging body (1).

5. The rat skin wrapping piece for drug administration according to claim 4, wherein the sub-patch (31) comprises a plurality of fine soft fiber layers which are uniformly fixed on one side of the front surface of the wrapping piece body (1) at intervals, the main patch (32) comprises a plurality of elastic fiber layers with barbs, the elastic fiber layers are uniformly fixed on one side of the back surface of the wrapping piece body (1) at intervals, the number of the fine soft fiber layers is consistent with that of the elastic fiber layers, and the positions of the soft fiber layers and the positions of the elastic fiber layers are in one-to-one correspondence.

6. The wrapping piece for rat skin administration according to claim 1, wherein a wrapping edge (4) is further arranged on one side of the wrapping piece body (1) close to the fixing hole (2).

7. The pack for rat skin administration according to claim 1, wherein the pack body (1) is made of an elastic and breathable flannel material.

8. A method of using a rat skin delivery pack according to any one of claims 1 to 7, comprising the steps of:

1) after skin administration is carried out on a rat, the fixing hole (2) is sleeved on the forelimb of the rat, and the concave part (12) corresponds to the abdominal cavity of the rat, so that the abdominal cavity of the rat is exposed and is not pressed by the wrapping piece body (1);

2) wrapping the wrapping piece body (1) along the body of the rat so that the wrapping piece body (1) completely wraps the body of the rat;

3) the sub-sticker (31) and the main sticker (32) of the snap fastener (3) are aligned and attached, so that the wrapping body (1) is ensured to wrap the rat in a proper tightness manner.