CN114650830B - 靶向cd371的抗原识别受体及其用途 - Google Patents

靶向cd371的抗原识别受体及其用途 Download PDF

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Publication number
CN114650830B
CN114650830B CN202080078104.8A CN202080078104A CN114650830B CN 114650830 B CN114650830 B CN 114650830B CN 202080078104 A CN202080078104 A CN 202080078104A CN 114650830 B CN114650830 B CN 114650830B
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amino acid
acid sequence
cell
certain embodiments
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CN114650830A (zh
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A·丹尼安
R·J·布伦特延斯
I·C·洛伦兹
M·A·波尔
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Cancer And Related Diseases Memorial Hospital
Sloan Caitlin Cancer Research Association
Three Institution Treatment Discovery Institute Inc
Memorial Sloan Kettering Cancer Center
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Cancer And Related Diseases Memorial Hospital
Sloan Caitlin Cancer Research Association
Three Institution Treatment Discovery Institute Inc
Memorial Sloan Kettering Cancer Center
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    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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CN202080078104.8A 2019-09-13 2020-09-11 靶向cd371的抗原识别受体及其用途 Active CN114650830B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962900141P 2019-09-13 2019-09-13
US62/900,141 2019-09-13
US201962936951P 2019-11-18 2019-11-18
US62/936,951 2019-11-18
PCT/US2020/050386 WO2021050862A1 (en) 2019-09-13 2020-09-11 Antigen recognizing receptors targeting cd371 and uses thereof

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CN114650830B true CN114650830B (zh) 2024-12-24

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WO2021050857A1 (en) * 2019-09-13 2021-03-18 Memorial Sloan-Kettering Cancer Center Anti-cd371 antibodies and uses thereof
EP4584283A1 (en) 2022-11-14 2025-07-16 Caribou Biosciences, Inc. Anti-cll-1 chimeric antigen receptors, engineered cells and related methods
TW202442689A (zh) * 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向ｐｓｍａ及ｃａ９之系統
WO2025193609A1 (en) 2024-03-11 2025-09-18 Caribou Biosciences, Inc. Methods and compositions for cost-effective assessment of nucleic acid transcripts and isoforms in cells

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WO2016014535A1 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
CN109641008A (zh) * 2016-04-01 2019-04-16 凯德药业股份有限公司 嵌合受体及其方法和用途
WO2019139888A1 (en) * 2018-01-09 2019-07-18 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods for targeting clec12a-expressing cancers

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WO2015188141A2 (en) * 2014-06-06 2015-12-10 Memorial Sloan-Kettering Cancer Ceneter Mesothelin-targeted chimeric antigen receptors and uses thereof
WO2017023859A1 (en) * 2015-07-31 2017-02-09 Memorial Sloan-Kettering Cancer Center Antigen-binding proteins targeting cd56 and uses thereof
EP3344263A4 (en) * 2016-08-04 2020-07-01 Memorial Sloan-Kettering Cancer Center CANCER ANTIGEN TARGETS AND USES THEREOF
US11905528B2 (en) * 2017-10-12 2024-02-20 Icell Gene Therapeutics Inc. Compound chimeric antigen receptor (cCAR) targeting multiple antigens, compositions and methods of use thereof
US20190284288A1 (en) * 2018-03-19 2019-09-19 The Regents Of The University Of Michigan Compositions and methods for t-cell and cytokine activation
IL279063B2 (en) * 2018-05-31 2026-05-01 Washington University St Louis Chimeric antigen receptor T cells for cancer treatment

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2016014535A1 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
CN109641008A (zh) * 2016-04-01 2019-04-16 凯德药业股份有限公司 嵌合受体及其方法和用途
WO2019139888A1 (en) * 2018-01-09 2019-07-18 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods for targeting clec12a-expressing cancers

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CN114650830A (zh) 2022-06-21
IL291281A (en) 2022-05-01
AU2020346887A1 (en) 2022-04-07
US20220213211A1 (en) 2022-07-07
KR20220068232A (ko) 2022-05-25
JP2025061323A (ja) 2025-04-10
EP4028031A1 (en) 2022-07-20
JP2022548112A (ja) 2022-11-16
MX2022003047A (es) 2022-06-14
BR112022004594A2 (pt) 2022-08-02
JP7776414B2 (ja) 2025-11-26
CA3154389A1 (en) 2021-03-18

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