CN114630673A - 用于治疗升高的同型半胱氨酸水平的胱硫醚β-合成酶酶疗法 - Google Patents

用于治疗升高的同型半胱氨酸水平的胱硫醚β-合成酶酶疗法 Download PDF

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CN114630673A
CN114630673A CN202080076522.3A CN202080076522A CN114630673A CN 114630673 A CN114630673 A CN 114630673A CN 202080076522 A CN202080076522 A CN 202080076522A CN 114630673 A CN114630673 A CN 114630673A
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M·塞洛斯-莫拉
E·M·布布利尔
F·格拉文
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Travier Therapy Switzerland Ltd
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Travier Therapy Switzerland Ltd
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
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    • G01N2800/00—Detection or diagnosis of diseases
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CN202080076522.3A 2019-09-03 2020-09-03 用于治疗升高的同型半胱氨酸水平的胱硫醚β-合成酶酶疗法 Pending CN114630673A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962895230P 2019-09-03 2019-09-03
US62/895,230 2019-09-03
US202062983862P 2020-03-02 2020-03-02
US62/983,862 2020-03-02
PCT/US2020/049156 WO2021046190A1 (en) 2019-09-03 2020-09-03 Cystathionine beta-synthase enzyme therapy for treatment of elevated homocysteine levels

Publications (1)

Publication Number Publication Date
CN114630673A true CN114630673A (zh) 2022-06-14

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CN202080076522.3A Pending CN114630673A (zh) 2019-09-03 2020-09-03 用于治疗升高的同型半胱氨酸水平的胱硫醚β-合成酶酶疗法

Country Status (11)

Country Link
US (1) US20220290116A1 (https=)
EP (1) EP4025243A4 (https=)
JP (2) JP2022546550A (https=)
KR (1) KR20220091464A (https=)
CN (1) CN114630673A (https=)
AU (1) AU2020343314A1 (https=)
BR (1) BR112022003539A2 (https=)
CA (1) CA3152379A1 (https=)
IL (1) IL290685A (https=)
MX (1) MX2022002571A (https=)
WO (1) WO2021046190A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3998067T3 (fi) 2015-11-09 2024-10-31 Univ Colorado Regents Koostumukset ja menetelmät homokystinurian hoitoon
IL269544B2 (en) 2017-04-17 2025-01-01 Univ Colorado Regents Streamlining enzyme replacement therapy for the treatment of high homocysteine
ES3058596T3 (en) * 2019-06-26 2026-03-11 Travere Therapeutics Switzerland Gmbh Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472277A (zh) * 2015-11-09 2018-08-31 科罗拉多州立大学董事会法人团体 用于治疗高胱氨酸尿症的组合物和方法
US20220265835A1 (en) * 2019-06-26 2022-08-25 The Regents Of The University Of Colorado, A Body Corporate Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034318B2 (en) * 2011-08-30 2015-05-19 The Regents Of The University Of Colorado, A Body Corporate Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
US9675678B2 (en) * 2013-01-29 2017-06-13 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for treatment of homocystinuria
IL269544B2 (en) * 2017-04-17 2025-01-01 Univ Colorado Regents Streamlining enzyme replacement therapy for the treatment of high homocysteine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472277A (zh) * 2015-11-09 2018-08-31 科罗拉多州立大学董事会法人团体 用于治疗高胱氨酸尿症的组合物和方法
US20220265835A1 (en) * 2019-06-26 2022-08-25 The Regents Of The University Of Colorado, A Body Corporate Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria

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Publication number Publication date
BR112022003539A2 (pt) 2022-05-24
CA3152379A1 (en) 2021-03-11
JP2022546550A (ja) 2022-11-04
AU2020343314A1 (en) 2022-03-24
US20220290116A1 (en) 2022-09-15
MX2022002571A (es) 2022-05-06
IL290685A (en) 2022-04-01
JP2025183204A (ja) 2025-12-16
EP4025243A1 (en) 2022-07-13
KR20220091464A (ko) 2022-06-30
EP4025243A4 (en) 2023-09-27
WO2021046190A1 (en) 2021-03-11

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