CN114617795A - Composition containing rehmannia glutinosa oligosaccharide and application thereof - Google Patents
Composition containing rehmannia glutinosa oligosaccharide and application thereof Download PDFInfo
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- CN114617795A CN114617795A CN202110412990.XA CN202110412990A CN114617795A CN 114617795 A CN114617795 A CN 114617795A CN 202110412990 A CN202110412990 A CN 202110412990A CN 114617795 A CN114617795 A CN 114617795A
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- Prior art keywords
- polysaccharide
- parts
- oligosaccharide
- composition
- rehmannia
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention relates to the field of skin care products, and in particular relates to a composition containing rehmannia glutinosa oligosaccharide and application thereof. The invention discloses a composition containing rehmannia glutinosa oligosaccharide, which comprises the following components: the white fungus polysaccharide, aloe polysaccharide, fucoidin and glutinous rehmannia oligosaccharide are selected from one or more of raffinose, stachyose, mannotriose and verbascose. The invention provides a composition containing glutinous rehmannia oligosaccharide and application thereof, wherein the glutinous rehmannia oligosaccharide has the effects of resisting bacteria and diminishing inflammation and can be used for repairing problems such as pimples, acnes and the like; the tremella polysaccharide, aloe polysaccharide and fucoidin have the effects of moisturizing; cordyceps polysaccharide, Polyporus polysaccharide, and Achyranthis radix polysaccharide have skin whitening effect; chitin and fructus Lycii polysaccharide have antiaging effect; rhizoma Polygonati polysaccharide and Ganoderma polysaccharide have effects of improving skin blood microcirculation; the plant polysaccharide and the rehmannia root oligosaccharide are compounded, so that the effects of well moisturizing, repairing skin aging, easily sensitizing, acne and the like can be achieved.
Description
Technical Field
The invention relates to the field of skin care products, and in particular relates to a composition containing rehmannia glutinosa oligosaccharide and application thereof.
Background
The rehmannia root contains the following chemical components: mainly glycosides and also contains saccharides: raffinose, stachyose, mannotriose, and verbascose. Wherein the rehmanniae radix oligosaccharide comprises raffinose, stachyose, mannotriose, and verbascose. Polysaccharides are substances widely existing in organisms, are natural polymer polymers formed by connecting aldose or ketose through glycosidic bonds, are important biological macromolecules in organisms, and are one of basic substances for maintaining normal operation of life activities. Plant polysaccharides are glycans produced by plant cell metabolism with a degree of polymerization of more than 10. Nowadays, plant polysaccharide research is receiving increasing attention, and scientific experimental research shows that many plant polysaccharides have biological activity, and have health care effects including immune regulation, anti-tumor, blood sugar reduction, blood fat reduction, radiation resistance, antibiosis and antivirus, liver protection and the like. Due to the excellent water absorption and high moisture retention characteristics of the plant polysaccharide, the plant polysaccharide is widely applied to the industries of cosmetics, foods and the like, and in the field of pure natural skin care, the plant polysaccharide is almost an indispensable blending agent and can be matched with other medicinal skin care ingredients to better protect the skin.
In life, due to factors such as environment, seasonal changes, living habits, physical and chemical injuries and the like, the water content of the skin is reduced, and the skin is dry and in a rough state and even cracks. At the moment, the skin is easy to be affected by the image of the external environment, and a series of problems of dull skin, acne growth and the like appear.
Therefore, it is very urgent to prepare a composition that can effectively solve the above-mentioned skin problems. Based on the research, the invention provides a composition containing rehmannia glutinosa oligosaccharide and application thereof, the composition is excellent in performance by compounding the rehmannia glutinosa oligosaccharide and plant polysaccharide, and meanwhile, the composition can be applied to various skin care products, can achieve good effects of moisturizing, and can solve the problem that the skin is dry and easy to damage.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising at least one of the following components: the white fungus polysaccharide, aloe polysaccharide, fucoidin, glutinous rehmannia oligosaccharide and elm bark polysaccharide, wherein the glutinous rehmannia oligosaccharide is one or more of raffinose, stachyose, mannotriose and verbascose.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 1-8 parts of tremella polysaccharide, 2-10 parts of aloe polysaccharide, 4-10 parts of fucoidin, 10-40 parts of rehmannia oligosaccharide and 1-10 parts of elm bark polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 3-5 parts of tremella polysaccharide, 4-8 parts of aloe polysaccharide, 6-8 parts of fucoidin, 20-32 parts of rehmannia root oligosaccharide and 4-6 parts of elm bark polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 1-4 parts of cordyceps polysaccharide, 1-8 parts of polyporus polysaccharide and 2-12 parts of achyranthes polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 2-3 parts of cordyceps polysaccharide, 3-6 parts of polyporus polysaccharide and 4-8 parts of achyranthes polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 3-9 parts of chitin and 4-15 parts of lycium barbarum polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 4-7 parts of chitin and 6-10 parts of lycium barbarum polysaccharide.
As a preferred technical scheme, the composition containing the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 1-5 parts of polygonatum polysaccharide and 3-10 parts of ganoderma polysaccharide.
As a preferable technical scheme, the composition containing the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 2-3 parts of polygonatum polysaccharide and 5-7 parts of ganoderma polysaccharide.
The second aspect of the invention provides application of the composition containing the rehmannia glutinosa oligosaccharide in skin care products, which are characterized in that the skin care products comprise essence water, facial masks and emulsion.
Has the beneficial effects that; the invention provides a composition containing glutinous rehmannia oligosaccharide and application thereof, wherein the glutinous rehmannia oligosaccharide has the functions of enhancing immunity, resisting bacteria and diminishing inflammation, and can effectively repair the problems of acne and the like on the skin; the tremella polysaccharide, aloe polysaccharide and fucoidin have the effects of resisting aging, supplementing water and keeping moisture; wherein the Cordyceps polysaccharide, Polyporus polysaccharide, and Achyranthis radix polysaccharide have effects of resisting radiation and whitening skin; wherein chitin and fructus Lycii polysaccharide have antibacterial and antiaging effects; rhizoma Polygonati polysaccharide and Ganoderma polysaccharide have effects of regulating immunity and improving skin blood microcirculation; the plant polysaccharide and the rehmannia root oligosaccharide are compounded, so that the effects of well moisturizing, repairing skin aging, easily sensitizing, acne and the like can be achieved. In the application, the tremella polysaccharide, the aloe polysaccharide, the fucoidin, the rehmannia glutinosa oligosaccharide, the elm bark polysaccharide, the cordyceps polysaccharide, the polyporus polysaccharide, the achyranthes bidentata polysaccharide, the chitin, the lycium barbarum polysaccharide, the polygonatum polysaccharide and the ganoderma lucidum polysaccharide have synergistic interaction, so that the fibroblast proliferation can be promoted, the cell migration can be promoted, and the DNA damage can be repaired.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definitions provided herein, the definition of the term provided herein controls.
As used herein, a feature that does not define a singular or plural form is also intended to include a plural form of the feature unless the context clearly indicates otherwise. It will be further understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "including," and/or "containing," when used in this specification means that the recited composition, step, method, article, or device is present, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or devices. Furthermore, the use of "preferred," "preferably," "more preferred," etc., when describing embodiments of the present application, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In order to solve the above problems, a first aspect of the present invention provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising at least one of the following components: the polysaccharide is one or more of raffinose, stachyose, mannotriose and verbascose.
Raffinose is the best known trisaccharide in nature, is formed by combining galactose, fructose and glucose, and is a functional oligosaccharide with strong bifidobacterium proliferation effect. Raffinose is widely present in plants in nature, and is contained in various amounts in the kernels of many oil crops of vegetables, fruits and rice. The main effects are as follows: anti-allergy acne, moisturizing and beautifying; proliferating bifidobacteria and regulating intestinal flora; inhibiting endotoxin, protecting liver function, etc. The raffinose is applied to cosmetics, can enhance the anti-allergic capacity and anti-inflammatory capacity of human skin, can prevent acne and pox of the facial skin of human, can prevent skin allergy, can be directly applied to the skin, can form a protective layer on the surface of the skin, can prevent the water loss of the skin, can eliminate the pox and the acne on the skin, and can enable the skin of people to become smoother and tender.
The raffinose of the present application may be commercially available, for example, as sold under the trade designation D832616-1g by Shanghai Micheln Biotech, Inc.
Stachyose is a saccharide formed by combining 2 alpha-galactose with 1, 6 glycosidic bonds on one side of glucose group of sucrose. Stachyose is a functional oligosaccharide, and does not have any dependence. The probiotics are bacteria beneficial to human and animals, maintain colony balance in intestinal tracts and have bidirectional regulation effects: helps to eliminate belly-pulling and stops constipation. Stachyose is a substance which is beneficial to probiotics, and when the probiotics are eaten by the substances, the human body can not digest the stachyose, and the prebiotics can reach the intestinal tract to feed the probiotics, so that the growth of the probiotics is facilitated. The two substances are different in nature, but the final result can play a role in bidirectional regulation, the action degrees are different, and the matching administration effect is excellent.
Stachyose in the application can be commercially available, and can also be prepared from rehmannia root under the condition of permission.
Mannotriose is a carbohydrate derived from rehmanniae radix Preparata. Mannotriose is the oligosaccharide ingredient with the highest content in rehmanniae radix Preparata. Can be prepared by hydrolyzing stachyose. The mannotriose has pharmacological activities of promoting the proliferation of hematopoietic cells, improving immunity, reducing blood sugar, resisting tumors and the like.
The mannotriose in this application can be a commercially available product, for example, sold under the trade designation M860556-5mg by Shanghai Michelin Biotech, Inc.
The verbascose belongs to galacto-oligosaccharide and is pentasaccharide in oligosaccharide. The verbascose has the functions of proliferating beneficial bacteria, enhancing intestinal colonization resistance, inhibiting harmful bacteria, regulating intestinal microecological balance, improving intestinal tracts and the like. The function of regulating the microecology is superior to that of all oligosaccharides applied at present, beneficial bacteria can be proliferated, a chemical barrier and a microbial barrier are formed, the intestinal colonization resistance is enhanced, harmful bacteria are inhibited, the microecology balance of the intestinal tract is regulated, and the intestinal function is improved; promoting intestinal peristalsis; promoting the absorption of vitamin B, protein and minerals such as calcium, iron, zinc, etc.; reducing and eliminating harmful substances in the body, and preventing toxins from entering blood circulation; eliminating free radicals in vivo; promoting blood circulation, improving hematopoietic function of bone marrow.
The verbascose in this application may be commercially available, for example, from Shanghai-derived leaf Biotech Co., Ltd under the product designation B27137-5 mg.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 1-8 parts of tremella polysaccharide, 2-10 parts of aloe polysaccharide, 4-10 parts of fucoidin, 10-40 parts of rehmannia oligosaccharide and 1-10 parts of elm bark polysaccharide.
Tremella polysaccharide is an acidic heteropolysaccharide and is obtained from Tremella sporophore. Is basidiomycete polysaccharide immunopotentiator, and has the effects of improving immunity and increasing leukocyte. Can significantly improve the phagocytic function of reticuloendothelial cells of experimental animals, promote nonspecific immunity, and improve the level of immunoglobulin and serum total complement. Can be used for preventing and treating bone marrow depression caused by radiation and antineoplastic agent (such as CTX), and promoting synthesis of protein in liver. The tremella polysaccharide has the following physiological effects: improving immunity, inhibiting tumor, delaying aging, regulating blood sugar and blood lipid, preventing thrombosis, resisting radiation, and protecting gastric mucosa.
The tremella polysaccharides in this application may be commercially available, for example, as sold under the trade designation T861210-20mg by Shanghai Micheln Biotech, Inc.
Aloe polysaccharide is the main bioactive component of aloe vera gel. Aloe polysaccharide is a large class of macromolecular compounds with different physiological functions, mainly comprises mannose, galactose, glucose, xylose, arabinose and rhamnose, wherein the contents of mannose, galactose and glucose are more, and viscous substances in aloe mesophyll mainly comprise mannan. Like other plant polysaccharides, aloe polysaccharide has health promotion effects of killing bacteria, diminishing inflammation, resisting virus, regulating immunity, resisting tumor, protecting liver, resisting radiation, resisting ulcer, resisting oxidation, resisting aging and lowering blood sugar. At present, no report of anaphylactic reaction caused by using aloe polysaccharide exists, and the toxic and side effects of the aloe polysaccharide are small.
The aloe polysaccharides herein may be commercially available, for example, as sold under the trade designation B24395-20mg from Shanghai-derived leaf Biotech, Inc.
Fucoidan is also called fucan, fucoidan, etc., is mainly derived from brown algae, and is a kind of polysaccharide containing fucose and sulfuric acid groups. It has several biological functions, such as anticoagulation, antitumor, antithrombotic, antivirus, antioxidant and enhancing body's immunity, so that it is widely used in medicine field and modern food industry. The fucoidin is applied in cosmetics, and has the effects of absorbing moisture, keeping moisture, resisting oxidation, resisting inflammation, whitening, resisting wrinkle and radiation, repairing skin tissue, and the like.
The fucoidan of the present application can be commercially available, for example, from Shanghai Michelin Biotechnology Ltd under the trade designation F885876-1 g.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 3-5 parts of tremella polysaccharide, 4-8 parts of aloe polysaccharide, 6-8 parts of fucoidin, 20-32 parts of rehmannia root oligosaccharide and 4-6 parts of elm bark polysaccharide.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 1-4 parts of cordyceps polysaccharide, 1-8 parts of polyporus polysaccharide and 2-12 parts of achyranthes polysaccharide.
Cordyceps polysaccharide is the main effective component of Cordyceps. Cordyceps polysaccharide is polysaccharide composed of mannose, cordycepin, adenosine, galactose, arabinose, saccharin, glucose, and fucose. Experiments prove that the cordyceps polysaccharide can improve the immunologic function of a human body and increase white blood cells, and is clinically used for treating malignant tumors. Has the following physiological activities: anti-tumor, blood sugar lowering, liver protecting, kidney protecting, and immunoregulation.
The cordyceps polysaccharide in the present application may be commercially available, for example, the product sold under the trade designation 5495553145 by Jianantong biologicals, Shanxi.
Polyporus polysaccharide is polysaccharide extracted from Polyporus umbellatus, and is mainly used for improving cellular immunity. The traditional Chinese medicine composition is clinically used for lung cancer, can reduce bleeding and infection of leukemia patients, relieve some adverse reactions of chemotherapy and prolong the life cycle of the patients. The product is polysaccharide substance extracted from Polyporus umbellatus, and is mainly used for improving cellular immunity of organism. The traditional Chinese medicine composition is clinically used for lung cancer, so that the function of macrophages is obviously enhanced, and the E rosette formation rate, OT test and other immune functions can be improved. Can reduce bleeding and infection of leukemia patients, relieve some adverse reactions of chemotherapy, and prolong the life of patients. The clinical application of Polyporus umbellatus polysaccharide has effects of promoting diuresis, eliminating dampness, resisting tumor and radiation, and treating rheumatism, edema, lung cancer, and gastric cancer.
The grifola polysaccharide in the present application may be commercially available, for example as sold under the trade designation REL-ZL10 by Sierra bioengineering, Inc.
The achyranthes polysaccharide is a bioactive polysaccharide extracted from achyranthes roots, is an active ingredient with high content in achyranthes roots of the foraging family, and mainly comprises 3 monosaccharide components of glucose, mannose and fructose; widely exists in animal, plant and microorganism tissues, and has various pharmacological effects of delaying aging, resisting oxidation, resisting tumor, regulating immunity, treating asthma, dredging collaterals, promoting blood circulation, reducing blood sugar, etc.
The achyranthes bidentata polysaccharides of the present application can be commercially available, for example, as a product sold under the trade name FT-R8514 by Shanghai Van dynasty Biotech.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 2-3 parts of cordyceps polysaccharide, 3-6 parts of polyporus polysaccharide and 4-8 parts of achyranthes polysaccharide.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 3-9 parts of chitin and 4-15 parts of lycium barbarum polysaccharide.
Chitin, also known as chitin, is a structurally homologous polysaccharide formed by the polymerization of N-acetylglucosamine through beta linkage. It is widely found in the shells of crustaceans, the crustaceans of insects, and the cell walls of fungi, and also in some green algae, mainly to serve as a skeleton for supporting the body and to protect the body. Has the following physiological effects: immune function activating effect, cancer cell metastasis preventing effect, cancer inhibiting effect, acidic body constitution improving effect, antibacterial effect, diabetes improving effect, intestinal beneficial bacteria increasing effect, pain relieving and hemostasis effect, hypertension inhibiting effect, and liver function enhancing effect.
Chitin in the present application can be a commercially available product, for example, sold by Shenzhen topology Biotechnology Limited.
The lycium barbarum polysaccharide is one of the most effective components of lycium barbarum pulp, is the essence of lycium barbarum and is easy to absorb. The lycium barbarum polysaccharide has the following physiological activities: reproductive system protection function, antioxidant, antiaging, immunity regulating, antitumor, blood lipid regulating, blood glucose reducing, radioprotective, neuroprotective and anticancer effects.
The lycium barbarum polysaccharides in this application may be commercially available, for example, from san Liang Biotechnology, Inc., of Ning shan.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 4-7 parts of chitin and 6-10 parts of lycium barbarum polysaccharide.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide further comprises the following components in parts by weight: 1-5 parts of polygonatum polysaccharide and 3-10 parts of ganoderma polysaccharide.
The polygonatum polysaccharide is the main functional component of polygonatum, and researches show that the polygonatum polysaccharide has certain activities of resisting oxidation, regulating immunity, resisting fatigue, resisting viruses, regulating blood sugar and blood fat, inhibiting bacteria, resisting inflammation and the like, and has good development and application prospects in the aspects of functional food and medical care.
The polygonatum polysaccharide in the present application may be commercially available, for example, as a product sold under the product number BL-2020102804 by the biotechnology limited of baysu, shanxi.
Ganoderan is a secondary metabolite of mycelium of fungus belonging to genus Ganoderma of family Polyporaceae, and is present in mycelium and fruiting body of fungus belonging to genus Ganoderma. The ganoderan is a light brown to tan powder, and is soluble in hot water. The ganoderan has the effects of reducing blood sugar and blood fat, resisting thrombus and oxidation, scavenging free radicals, resisting aging, radiation and tumor, promoting blood circulation, regulating immunity, regulating nucleic acid and protein metabolism, promoting DNA synthesis, and promoting proliferation of LAK cell in cord blood. The ganoderma lucidum polysaccharide has special physiological activity and clinical effect, is safe and nontoxic, and can be widely applied to the industries of medicine, food and cosmetics.
The ganoderan of the present application may be commercially available, for example, as SQLZ from St.John, Biotech, Inc.
In some preferred embodiments, the composition comprising the rehmannia glutinosa oligosaccharide comprises the following components in parts by weight: 2-3 parts of polygonatum polysaccharide and 5-7 parts of ganoderma polysaccharide.
The second aspect of the invention provides application of the composition containing the rehmannia glutinosa oligosaccharide in skin care products, which are characterized in that the skin care products comprise essence water, facial masks and emulsion.
The rehmannia glutinosa oligosaccharide in the application can be prepared from rehmannia glutinosa powder or can be directly purchased.
In one embodiment, the method for preparing the rehmannia glutinosa oligosaccharide comprises: crushing a rehmannia root raw material to 10-30 meshes; dynamically extracting the rehmannia powder by taking subcritical water as an extracting solution; filtering to obtain supernatant, purifying the supernatant by anion exchange resin, and collecting effluent liquid; adding deionized water for elution, collecting eluent, and mixing the effluent and the eluent; desalting the obtained feed liquid by using cation exchange resin; adding deionized water for elution, collecting eluent, and mixing the effluent and the eluent; filtering the obtained feed liquid with microporous membrane, concentrating under reduced pressure, and drying.
The specific preparation parameters of the rehmanniae radix oligosaccharides in the present application are not particularly limited, and those skilled in the art can routinely select the parameters according to the actually required properties of the rehmanniae radix oligosaccharide species.
The preparation method of stachyose comprises the following steps: crushing a rehmannia root raw material to 10-30 meshes; and dynamically extracting the rehmannia powder by taking subcritical water as an extracting solution, wherein the material-to-liquid ratio of the rehmannia powder to the water is 1 g: 6mL, the extraction time is 30min, the extraction pressure is 5MPa, and the extraction temperature is 120 ℃; filtering to obtain supernatant, purifying the supernatant with anion exchange resin at flow rate of 3m3Resin/h, collecting effluent liquid; adding deionized water for elution, collecting eluent, and mixing the effluent and the eluent; desalting the obtained feed solution with cation exchange resin at flow rate of 10m3Resin/h, collecting effluent liquid; adding deionized water for elution, collecting eluent, and mixing effluent and eluent; filtering the obtained feed liquid with 0.6-0.8 μm microporous membrane, concentrating at 70 deg.C under reduced pressure, and drying to obtain stachyose product.
Examples
The technical solution of the present invention is described in detail by the following examples, but the scope of the present invention is not limited to the examples. The starting materials in the present invention are commercially available, unless otherwise specified, and can be prepared from rehmannia glutinosa, if conditions permit.
The preparation method of stachyose comprises the following steps: crushing a rehmannia root raw material to 10-30 meshes; and dynamically extracting the rehmannia powder by taking subcritical water as an extracting solution, wherein the material-to-liquid ratio of the rehmannia powder to the water is 1 g: 6mL, the extraction time is 30min, the extraction pressure is 5MPa, and the extraction temperature is 120 ℃; filtering to obtain supernatant, purifying the supernatant with anion exchange resin at flow rate of 3m3Resin/h, yieldCollecting and discharging liquid; adding deionized water for elution, collecting eluent, and mixing effluent and eluent; desalting the obtained feed solution with cation exchange resin at flow rate of 10m3Resin/h, collecting effluent liquid; adding deionized water for elution, collecting eluent, and mixing the effluent and the eluent; filtering the obtained feed liquid with 0.6-0.8 μm microporous membrane, concentrating at 70 deg.C under reduced pressure, and drying to obtain stachyose product.
The raffinose in this application is purchased from Shanghai Michelin Biochemical technology, Inc. under the product designation D832616-1 g.
Mannotriose in this application is available from Shanghai Michelin Biotechnology Limited under the trade designation M860556-5 mg.
The verbascose is obtained from the product sold under the trade name B27137-5mg from Shanghai-derived leaf Biotechnology Ltd.
The tremella polysaccharide in the application is purchased from a product sold by Shanghai Michelin Biotechnology Limited with a product number of T861210-20 mg.
Aloe polysaccharide in this application is purchased from Shanghai-derived leaf Biotech Co., Ltd under a product number of B24395-20 mg.
Fucoidan in this application is purchased from Shanghai Michelin Biotechnology Ltd under the trade designation F885876-1 g.
The cordyceps polysaccharide in the application is purchased from a product sold by Jiantong biological products Limited in Shaanxi with the product number of 5495553145.
Polyporus polysaccharide in this application is purchased from the product sold under the trade name REL-ZL10 by Sierra bioengineering, Inc.
The achyranthes bidentata polysaccharides are purchased from Shanghai Van ecology Biotech Co., Ltd under the trade name FT-R8514.
Chitin in this application was purchased from a product sold by Shenzhen topology Biotechnology Limited.
The lycium barbarum polysaccharides in the application are purchased from the product with the product number of 003 sold by saint biotechnology limited of Shaannan province.
The polygonatum polysaccharide in the application is purchased from a product with a product number of BL-2020102804 sold by Shaanxi Bolin biotechnology limited company.
The ganoderan in this application is purchased from the product sold by sienna holy biotechnology limited under the product number SQLZ.
The elm bark polysaccharide in this application is purchased from ningxia vanilla biotechnology limited with a specification of 20: 1.
Example 1
Example 1 provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 4 parts of tremella polysaccharide, 6 parts of aloe polysaccharide, 7 parts of fucoidin, 6 parts of raffinose, 6 parts of stachyose, 6 parts of mannotriose, 6 parts of verbascose, 2.5 parts of cordyceps polysaccharide, 5 parts of polyporus polysaccharide, 6 parts of achyranthes polysaccharide, 5 parts of chitin, 8 parts of lycium polysaccharide, 2.5 parts of polygonatum polysaccharide, 6 parts of ganoderma polysaccharide and 5 parts of elm bark polysaccharide.
Example 2
Embodiment 2 provides a composition containing a rehmannia glutinosa oligosaccharide, which comprises the following components in parts by weight: 1 part of tremella polysaccharide, 2 parts of aloe polysaccharide, 4 parts of fucoidin, 2.5 parts of raffinose, 2.5 parts of stachyose, 2.5 parts of mannotriose, 2.5 parts of verbascose, 1 part of cordyceps polysaccharide, 1 part of polyporus polysaccharide, 2 parts of achyranthes polysaccharide, 3 parts of chitin, 4 parts of lycium barbarum polysaccharide, 1 part of polygonatum polysaccharide, 3 parts of ganoderma polysaccharide and 1 part of elm bark polysaccharide.
Example 3
Embodiment 3 provides a composition containing a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 8 parts of tremella polysaccharide, 10 parts of aloe polysaccharide, 10 parts of fucoidin, 10 parts of raffinose, 10 parts of stachyose, 10 parts of mannotriose, 10 parts of verbascose, 4 parts of cordyceps polysaccharide, 8 parts of polyporus polysaccharide, 12 parts of achyranthes bidentata polysaccharide, 9 parts of chitin, 15 parts of lycium barbarum polysaccharide, 5 parts of polygonatum polysaccharide, 10 parts of ganoderma polysaccharide and 10 parts of elm bark polysaccharide.
Comparative example 1
Comparative example 1 provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 4 parts of tremella polysaccharide, 6 parts of aloe polysaccharide, 7 parts of fucoidin, 6 parts of raffinose, 6 parts of stachyose, 6 parts of mannotriose, 6 parts of verbascose, 2.5 parts of cordyceps polysaccharide, 5 parts of polyporus polysaccharide, 6 parts of achyranthes polysaccharide, 5 parts of chitin, 8 parts of lycium polysaccharide, 0 part of polygonatum polysaccharide, 0 part of ganoderma polysaccharide and 5 parts of elm bark polysaccharide.
Comparative example 2
Embodiment 2 provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 4 parts of tremella polysaccharide, 6 parts of aloe polysaccharide, 7 parts of fucoidin, 6 parts of raffinose, 6 parts of stachyose, 6 parts of mannotriose, 6 parts of verbascose, 2.5 parts of cordyceps polysaccharide, 5 parts of polyporus polysaccharide, 6 parts of achyranthes polysaccharide, 0 part of chitin, 0 part of lycium polysaccharide, 2.5 parts of polygonatum polysaccharide, 6 parts of ganoderma polysaccharide and 5 parts of elm bark polysaccharide.
Comparative example 3
Comparative example 3 provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 4 parts of tremella polysaccharide, 6 parts of aloe polysaccharide, 7 parts of fucoidin, 6 parts of raffinose, 6 parts of stachyose, 6 parts of mannotriose, 6 parts of verbascose, 0 part of cordyceps polysaccharide, 0 part of polyporus polysaccharide, 0 part of achyranthes bidentata polysaccharide, 5 parts of chitin, 8 parts of lycium barbarum polysaccharide, 2.5 parts of polygonatum polysaccharide, 6 parts of ganoderma polysaccharide and 5 parts of elm bark polysaccharide.
Comparative example 4
Comparative example 4 provides a composition comprising a rehmannia glutinosa oligosaccharide, comprising the following components in parts by weight: 0 part of tremella polysaccharide, 0 part of aloe polysaccharide, 0 part of fucoidin, 6 parts of raffinose, 6 parts of stachyose, 6 parts of mannotriose, 6 parts of verbascose, 2.5 parts of cordyceps polysaccharide, 5 parts of polyporus polysaccharide, 6 parts of achyranthes polysaccharide, 5 parts of chitin, 8 parts of lycium polysaccharide, 2.5 parts of polygonatum polysaccharide, 6 parts of ganoderma polysaccharide and 5 parts of elm bark polysaccharide.
Evaluation of Performance
1. Efficacy measurement of different examples for moisturizing the stratum corneum of the skin
Healthy skin should be smooth, moist, and elastic, which is largely attributable to the moisture in the skin, and these appearance signs are related to the function of the skin's own moisturizing system. The moisturizing system has the functions of maintaining a certain moisture content of the skin and resisting the damage of evaporative dryness, even embrittlement and the like to the skin caused by internal and external factors. When the water content of the skin is sufficient, the skin becomes full of water, and particularly, the water content of the stratum corneum directly influences the apparent state of the skin.
Whether the skin looks dry on the surface mainly depends on the water content of the horny layer of the epidermis, and the skin is moist, compact and elastic, and is the most ideal skin state; when the water content of the skin is too low, the skin becomes dry, rough and even cracked. Meanwhile, when the skin is in a dry and dry state, the skin is very fragile and is easily influenced by the environment, so that a series of problems of dull skin, easy sensitization, aging and the like occur.
80 volunteers were selected for the test and divided into 8 groups of 10 persons each, one group being a control group and not treated, and the remaining 7 groups, and the test was performed using the skin care products prepared using the compositions of examples 1-3 and comparative examples 1-4 as additives, which were essence water prepared from the composition of the present application in 10% by weight and deionized water in 90% by weight. The 80 volunteers respectively wash the face with clear water and wipe clean, at the moment, the digital skin moisture detector is used for measuring the moisture content of the skin, then the skin care product is uniformly smeared on the face, then the moisture content of the skin is respectively measured after 0.5h, 1h, 2h, 4h and 8h, the average value of each group of measurement results is calculated, and the average value of the moisture content is obtained, which is shown in the following table.
TABLE 1 average value of skin moisture content at different times
From the above table, it can be seen that the use of the composition of the present application is effective in increasing skin moisture content, with example 1 being the most preferred example.
Finally, it should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the above-mentioned embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be regarded as equivalent replacements within the protection scope of the present invention.
Claims (10)
1. A composition comprising a rehmannia glutinosa oligosaccharide, comprising at least one of the following: the polysaccharide is one or more of raffinose, stachyose, mannotriose and verbascose.
2. A composition comprising a rehmannia glutinosa oligosaccharide according to claim 1, comprising the following components in parts by weight: 1-8 parts of tremella polysaccharide, 2-10 parts of aloe polysaccharide, 4-10 parts of fucoidin, 10-40 parts of rehmannia oligosaccharide and 1-10 parts of elm bark polysaccharide.
3. A composition comprising a rehmanniae oligosaccharide according to claim 2, comprising the following components in parts by weight: 3-5 parts of tremella polysaccharide, 4-8 parts of aloe polysaccharide, 6-8 parts of fucoidin, 20-32 parts of rehmannia root oligosaccharide and 4-6 parts of elm bark polysaccharide.
4. A composition comprising rehmania oligosaccharide according to claim 3, further comprising the following components in parts by weight: 1-4 parts of cordyceps polysaccharide, 1-8 parts of polyporus polysaccharide and 2-12 parts of achyranthes polysaccharide.
5. A composition comprising rehmania oligosaccharide according to claim 4, wherein the composition comprises the following components in parts by weight: 2-3 parts of cordyceps polysaccharide, 3-6 parts of polyporus polysaccharide and 4-8 parts of achyranthes polysaccharide.
6. A composition comprising rehmania oligosaccharide according to claim 5, further comprising the following components in parts by weight: 3-9 parts of chitin and 4-15 parts of lycium barbarum polysaccharide.
7. A composition comprising rehmania oligosaccharide according to claim 6, wherein the composition comprises the following components in parts by weight: 4-7 parts of chitin and 6-10 parts of lycium barbarum polysaccharide.
8. A composition comprising rehmania oligosaccharide according to claim 7, further comprising the following components in parts by weight: 1-5 parts of polygonatum polysaccharide and 3-10 parts of ganoderma polysaccharide.
9. A composition comprising rehmania oligosaccharide according to claim 8, wherein the composition comprises the following components in parts by weight: 2-3 parts of polygonatum polysaccharide and 5-7 parts of ganoderma polysaccharide.
10. Use of a composition comprising a rehmanniae oligosaccharide according to any of claims 1-9 in a skin care product comprising serum, mask, lotion.
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| CN111920707A (en) * | 2020-09-04 | 2020-11-13 | 博雅(广州)生物科技研究院有限公司 | Skin care composition with moisturizing and anti-aging effects and preparation method and application thereof |
| WO2021003962A1 (en) * | 2019-07-11 | 2021-01-14 | 浙江康满家日用品有限公司 | Skincare composition for repairing skin, and preparation method therefor |
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| WO2021003962A1 (en) * | 2019-07-11 | 2021-01-14 | 浙江康满家日用品有限公司 | Skincare composition for repairing skin, and preparation method therefor |
| CN111920707A (en) * | 2020-09-04 | 2020-11-13 | 博雅(广州)生物科技研究院有限公司 | Skin care composition with moisturizing and anti-aging effects and preparation method and application thereof |
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