CN114603858A - Semi-quantitative precision measurement method and system based on extrusion type biological 3D printing - Google Patents

Semi-quantitative precision measurement method and system based on extrusion type biological 3D printing Download PDF

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Publication number
CN114603858A
CN114603858A CN202210212622.5A CN202210212622A CN114603858A CN 114603858 A CN114603858 A CN 114603858A CN 202210212622 A CN202210212622 A CN 202210212622A CN 114603858 A CN114603858 A CN 114603858A
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printing
semi
extrusion
quantitative
filaments
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CN114603858B (en
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尚建忠
林泽宁
蒋涛
罗自荣
洪阳
卢钟岳
白向娟
杨云
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National University of Defense Technology
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National University of Defense Technology
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30—Auxiliary operations or equipment
    • B29C64/386—Data acquisition or data processing for additive manufacturing
    • B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00—Data acquisition or data processing for additive manufacturing
    • B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes

Abstract

The invention discloses a semi-quantitative precision measurement method and system based on extrusion type biological 3D printing. The method comprises the following steps: s1, printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters; s2, randomly selecting multiple positions to measure the distance between two filaments, and calculating the average value X and standard deviation XSDDividing the average value X by the design distance W to obtain a semi-quantitative coefficient R; s3, repeating the steps S1-S2 for a plurality of times, and selecting the printing parameter corresponding to the semiquantitative coefficient R closest to 1 from the plurality of semiquantitative coefficients R. The invention can use less materials to obtain better parameters before printing more complex models, thereby keeping higher printing quality and printing precision of various complex structures.

Description

Semi-quantitative precision measurement method and system based on extrusion type biological 3D printing
Technical Field
The invention relates to the technical field of materials, in particular to a semi-quantitative precision measurement method based on extrusion type biological 3D printing.
Background
At present, common biological 3D printing modes include extrusion type biological 3D printing, photocuring printing and the like, wherein the extrusion type biological 3D printing is the most widely applied biological 3D printing method. The extrusion type biological 3D printer can print biological materials with different viscosities and cells with different concentrations, so that the application is wider compared with other printing modes. The material for biological 3D printing belongs to a soft material (such as hydrogel), and unreasonable printing parameters in the printing process can cause the printed structure to have lower precision and rougher structure. At present, the research on the printing quality measurement of the structure formed by the extrusion type biological 3D printing mode is less. Therefore, it is necessary to develop a semi-quantitative accuracy measurement method based on extrusion type bio-3D printing.
Disclosure of Invention
The invention aims to provide a semi-quantitative precision measuring method based on extrusion type biological 3D printing, which overcomes the defects in the prior art.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the semi-quantitative precision measurement method based on the extrusion type biological 3D printing comprises the following steps:
s1, printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters;
s2, randomly selecting multiple positions to measure the distance between two filaments, and calculating the average value X and standard deviation XSDDividing the average value X by the design distance W to obtain a semi-quantitative coefficient R;
s3, repeating the steps S1-S2 for a plurality of times, and selecting the printing parameter corresponding to the semiquantitative coefficient R closest to 1 from the plurality of semiquantitative coefficients R.
Further, the printing material used by the extrusion type biological 3D printer in step S1 is a gel material.
Further, the extrusion type biological 3D printer performs printing on the platform in step S1.
Further, the printing parameters in the step S1 are the distance that the nozzle tip is kept above the platform, the nozzle translation speed, the nozzle type, the gel time of the material, and the printing pressure.
Further, in the step S2, 10 positions are arbitrarily selected to measure the distance between the two filaments.
Further, the step S3 includes repeating the steps S1-S2 at least three times.
Further, in step S3, the printing accuracy is improved as the semi-quantization factor R is closer to 1.
The invention also provides a semi-quantitative precision measurement system based on extrusion type biological 3D printing, which comprises:
the printing module is used for printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters;
a calculation module for measuring the distance between two filaments at any selected position and calculating the average value X and standard deviation XSDDividing the average value X by the design distance W to obtain a semi-quantitative coefficient R;
the precision judging module is used for repeating the steps in the printing module and the calculating module for multiple times, and selecting the printing parameter corresponding to the semi-quantitative coefficient R closest to 1 from the semi-quantitative coefficients R;
the printing module, the calculating module and the precision judging module are connected in sequence.
Compared with the prior art, the invention has the advantages that: according to the semi-quantitative precision measuring method based on the extrusion type biological 3D printing, provided by the invention, less materials can be used for obtaining better parameters before a more complex model is printed, so that various complex structures can keep higher printing quality and printing precision.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a flow chart of a semi-quantitative accuracy measurement method based on extrusion biological 3D printing according to the present invention.
FIG. 2 is a schematic diagram of the semi-quantitative accuracy measurement method based on extrusion biological 3D printing.
FIG. 3 is a schematic diagram of a semi-quantitative accuracy measurement system based on extrusion-based bio-3D printing according to the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, and the scope of the present invention will be more clearly and clearly defined.
Example one
Referring to fig. 1 and fig. 2, the present embodiment discloses a semi-quantitative precision measurement method based on extrusion biological 3D printing, which includes the following steps:
and step S1, printing at least two filaments by adopting an extrusion type biological 3D printer under the same printing parameter condition.
Specifically, the printing material is a gel material, such as gelatin, sodium alginate and other gel materials, and the materials belong to soft material. When the set printing parameters are unreasonable, the printed structure may have the problems of low printing structure precision and rough structure, when the structure is printed, a printer prints a first layer structure on a plane, and whether the distance between the filaments between the first layer structure is consistent with the design or not determines the printing precision, so that the gel material printing precision is determined by judging whether the gel material printing precision is good or not based on different printing parameters and materials, and the optimized printing parameters and printing structure are obtained.
Wherein, extrude biological 3D printer of formula and print on the platform, this platform can be plastics or metal material.
Among the printing parameters are the distance the nozzle tip is held above the platform, the nozzle translation speed, the nozzle type, the gel time of the material, and the printing pressure.
Step S2, arbitrarily selecting multiple positions to measure the distance between two filaments, and calculating the average value X and standard deviation XSDThe average value X is divided by the design pitch W to obtain a semi-quantitative coefficient R, and the calculation formula is as follows.
X＝(∑xi)/10，i＝1，2...10
XSD＝{[∑(xi-X)^2]/10}^(1/2)
R＝(X/W)×100％
Specifically, the distance between two filaments was measured at 10 arbitrary positions, and then the average value X and the standard deviation X were takenSD。
Step S3, repeating steps S1-S2 for a plurality of times, in this embodiment, 3 times are selected, and the printing parameter corresponding to the semi-quantitative coefficient R closest to 1 is selected from the plurality of semi-quantitative coefficients R, and the printing quality precision corresponding to the printing parameter is higher, so that the quality of the structural model printed by the printing parameter is better.
To describe the method of this embodiment in more detail, the prepared printing material is put into a 10cc syringe with a conical/cylindrical nozzle (various nozzle sizes, such as 23, 25, 27, etc.) as shown in fig. 2 for pneumatic extrusion, and the gel time t is 30min (which can range from 20 to 120min at room temperature, but the longer the gel time, the harder the extrusion, and the higher the pressure required, the lower the printing accuracy). Printing parameters (including pressure P, height h of the nozzle from the platform, etc.) are set for the printer. Printing parameters 2 filaments were printed (both filaments printing parameters were identical) using a pressure of 100Kpa, a nozzle tip held 0.4mm above the platform, a translation speed of 6 mm/s.
After printing, the distance between two filaments is measured at 10 optional positions, and the average value X and the standard deviation X are takenSD. The mean value X was divided by the designed spacing W to obtain the semi-quantitative coefficient R, and each set of experiments was repeated at least 3 times. The closer R is to 1, the closer the pitch is to the designed pitch, the higher the printing accuracy is, and the printing parameter corresponding to R closest to 1 is selected.
Example two
Referring to fig. 3, the present embodiment provides a system for implementing a semi-quantitative accuracy measurement method based on extrusion-based bio-3D printing according to the first embodiment, including: the printing module 1 is used for printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters; a calculation module 2 for measuring the distance between two filaments at any selected position and calculating the average X and standard deviation XSDDividing the average value X by the design distance W to obtain a semi-quantitative coefficient R; the precision judging module 3 is used for repeating the steps in the printing module and the calculating module for multiple times, and selecting the printing parameter corresponding to the semi-quantitative coefficient R closest to 1 from the semi-quantitative coefficients R; the printing module 1, the calculating module 2 and the precision judging module 3 are connected in sequence.
The invention can use less materials to obtain better parameters before printing more complex models, thereby keeping higher printing quality and printing precision of various complex structures.
Although the embodiments of the present invention have been described with reference to the accompanying drawings, various changes or modifications can be made by the owner within the scope of the appended claims, and the scope of the present invention should be covered by the owner as long as the protection scope of the present invention is not exceeded by the claims.

Claims (7)

1. The semi-quantitative precision measurement method based on extrusion type biological 3D printing is characterized by comprising the following steps of:
s1, printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters;
s2, randomly selecting multiple positions to measure the distance between two filaments, and calculating the average value X and standard deviation XSDDividing the mean value X by the design distance W to obtain the semi-definite valueQuantizing the coefficient R;
s3, repeating the steps S1-S2 for a plurality of times, and selecting the printing parameter corresponding to the semiquantitative coefficient R closest to 1 from the plurality of semiquantitative coefficients R.
2. The method for semi-quantitatively determining the accuracy based on the extrusion biological 3D printing of claim 1, wherein the printing material used by the extrusion biological 3D printer in the step S1 is a gel material.
3. The method for semi-quantitative accuracy measurement based on extrusion biological 3D printing according to claim 1, wherein the extrusion biological 3D printer prints on a platform in step S1.
4. The semi-quantitative accuracy measurement method based on extrusion-based bio 3D printing of claim 3, wherein the printing parameters in step S1 are distance of nozzle tip held above platform, nozzle translation speed, nozzle type, gel time of material and printing pressure.
5. The semi-quantitative accuracy measurement method based on extrusion-based bio 3D printing of claim 1, wherein 10 positions are arbitrarily selected in the step S2 to measure the distance between two filaments.
6. The method for semi-quantitative accuracy measurement based on extrusion-based bio-3D printing according to claim 1, wherein the step S3 further comprises repeating the steps S1-S2 at least three times.
7. The system of semi-quantitative accuracy measurement method based on extrusion-based bio-3D printing according to any one of claims 1 to 6, comprising:
the printing module is used for printing at least two filaments by adopting an extrusion type biological 3D printer under the condition of the same printing parameters;
a calculation module,For measuring the distance between two adjacent filaments at arbitrarily selected positions, and calculating the average value X and standard deviation X thereofSDDividing the average value X by the design distance W to obtain a semi-quantitative coefficient R;
the precision judging module is used for repeating the steps in the printing module and the calculating module for multiple times, and selecting the printing parameter corresponding to the semi-quantitative coefficient R closest to 1 from the semi-quantitative coefficients R;
the printing module, the calculating module and the precision judging module are connected in sequence.
CN202210212622.5A 2022-03-06 2022-03-06 Semi-quantitative precision measurement method and system based on extrusion type biological 3D printing Active CN114603858B (en)

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