CN114602361B - Clinical instrument of examining of oncology - Google Patents
Clinical instrument of examining of oncology Download PDFInfo
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- CN114602361B CN114602361B CN202210525757.7A CN202210525757A CN114602361B CN 114602361 B CN114602361 B CN 114602361B CN 202210525757 A CN202210525757 A CN 202210525757A CN 114602361 B CN114602361 B CN 114602361B
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- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 117
- 239000002775 capsule Substances 0.000 claims abstract description 86
- 230000008602 contraction Effects 0.000 claims abstract description 14
- 238000003805 vibration mixing Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims description 38
- 238000005485 electric heating Methods 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 238000005192 partition Methods 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 10
- 238000012423 maintenance Methods 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 238000007689 inspection Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 6
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The application discloses an oncology clinical primary examination instrument, which relates to the technical field of detection equipment and comprises a vibration mixing device, a clamp device, a power assembly and a control unit, wherein a clamp supporting body is positioned at the top of the vibration mixing device, and the clamp device is fixed at the top of the clamp supporting body; the fixture device comprises a capsule body supporting assembly, a clamping capsule body and a capsule body expansion and contraction assembly; the clamping bag body is an elastic bag body, and the main body is cylindrical; the bottom of the clamping bag body is positioned on the bag body supporting component, clamping holes are densely distributed on the clamping bag body, the clamping holes are through holes, the clamping holes are not communicated with the internal space of the clamping bag body, and the diameter of the clamping holes is larger than that of the reagent tubes before the clamping bag body is expanded; the balloon expansion and contraction assembly is used for controlling the expansion and contraction of the clamping balloon; the fixture device for the clinical primary examination instrument for the oncology department is simple in structure, the quantity of the reagent tubes capable of being clamped in a unit area is large, and the manufacturing cost and the later maintenance cost are both low.
Description
Technical Field
The invention relates to the technical field of detection equipment, in particular to an initial detection instrument for clinical oncology.
Background
The department of health control in 4 months in 2005 published the first cause of death among various causes of cancer death in our country, and the main reason is that cancer has progressed to the middle and late stages when patients seek medical advice. Therefore, early detection, early diagnosis and early treatment of tumors are the most important ways for patients to obtain long-term survival; the cancer screening is born under the condition, the screening method is simple and easy to implement, and early malignant tumor cells in vivo can be detected only by taking blood and reacting with a tumor-related substance detection reagent.
At present, when the existing primary examination instrument is used for carrying out primary examination on blood of a patient, the blood of the patient and a tumor-related substance detection reagent need to be mixed, and the manual mixing mode has high labor intensity and low working efficiency; to solve the above problems, chinese patent No. CN109596406B discloses a clinical primary examination instrument for oncology department, which is characterized in that a plurality of reagent tubes are clamped and fixed at one time by a strip-shaped fixture device composed of a movable column, a clamping block with an arc-shaped clamping groove, a gear, a rack, a rotating shaft and a stepping motor, and the uniform mixing of reagent and blood is realized by a mixing assembly composed of a motor, a cam, a spring, a plate body, a turntable and a connecting rod, thereby realizing the effect of improving the mixing efficiency.
However, the clamp device in the above scheme has a complex structure, the number of the reagent tubes which can be clamped in a unit area is small, the clamping action of the reagent tubes needs linkage of a plurality of components, the manufacturing cost is high, and the difficulty of later maintenance is large (the use cost is high) due to the complex structure.
Disclosure of Invention
The embodiment of the application provides a clinical primary examination instrument for oncology, and solves the technical problems that in the prior art, a clamp device for clamping a reagent tube of the clinical primary examination instrument for oncology is complex in structure, the quantity of the reagent tubes capable of being clamped in a unit area is small, and the manufacturing and later maintenance costs are high; the fixture device for the clinical primary examination instrument for the oncology department is simple in structure, the quantity of the reagent tubes capable of being clamped in a unit area is large, and the manufacturing cost and the later maintenance cost are both low.
The embodiment of the application provides a clinical primary examination instrument for oncology, which comprises a vibration mixing device, a clamp device, a power assembly and a control unit, wherein the vibration mixing device is used for mixing substances in a reagent tube in a mode of shaking the clamp device; the fixture device comprises a capsule body supporting assembly, a clamping capsule body and a capsule body expansion and contraction assembly;
the bag body supporting assembly is of a box body structure or a frame structure and is positioned at the top of the clamp supporting body;
the clamping bag body is an elastic bag body, and the main body is cylindrical or prismatic;
the bottom of the clamping bag body is positioned on the bag body supporting component, clamping holes are densely distributed in the clamping bag body, the axial direction of each clamping hole is the same as the height direction of the clamping bag body and is a through hole, the clamping holes are not communicated with the internal space of the clamping bag body, and the diameter of each clamping hole is larger than that of the reagent tube before the clamping bag body is expanded;
the balloon expansion and contraction component is used for controlling the expansion and contraction of the clamping balloon and is a pump.
Preferably, the device also comprises a medium temperature control component;
the clamping bag body is provided with a plurality of clamping bag bodies, and the clamping bag bodies are arranged in the bag body in a sealed mode;
the medium temperature control assembly comprises temperature control columns, the temperature control columns are cylindrical, are densely distributed on the upper surface of the capsule body supporting assembly and are inserted into the penetrating holes, and the temperature control columns correspond to the penetrating holes one by one and are distributed on the periphery of the clamping holes; the surface of the temperature control column is densely provided with electric heating sheets or heating wires which operate under the control of the control unit.
Preferably, the device also comprises a medium temperature control assembly, wherein the medium temperature control assembly comprises a temperature control column;
the temperature control columns are cylindrical, are positioned inside the clamping bag body, are multiple in number, have the same axial direction as the clamping holes and are distributed on the periphery of the clamping holes;
the surface of the temperature control column is densely provided with electric heating sheets or heating wires which operate under the control of the control unit.
Preferably, the device also comprises a medium temperature control component;
the medium temperature control assembly comprises an elastic support body and a heating wire;
the elastic supporting body is of a spring structure and plays a role in supporting the heating wires, two ends of the elastic supporting body are fixed in the clamping bag body, and the elastic supporting body is provided with a plurality of clamping holes which correspond to the clamping holes one by one;
the axis of the elastic support body is superposed with the axis of the clamping hole;
the heating wire is an electric heating wire, is positioned on the elastic supporting body and operates under the control of the control unit.
Preferably, the clamping capsule body is matched with a special reagent tube bracket;
the reagent tube bracket comprises a support frame, a limiting sheet and a sliding bottom plate;
the supporting frame is used for supporting the limiting sheet; the limiting sheet is used for limiting the spatial position of each reagent tube on the reagent tube bracket;
the sliding bottom plate is in a plate shape, is positioned on the supporting frame in a sliding mode and is positioned below the limiting piece, and the sliding direction is perpendicular to the height direction of the supporting frame;
lower leakage holes are densely distributed on the sliding bottom plate; the lower leak hole is a through hole, is in one-to-one correspondence with the reagent tubes on the reagent tube support and is positioned under the reagent tubes on the reagent tube support, the diameter of the lower leak hole is larger than that of the reagent tubes, the sliding bottom plate plays a supporting role for the reagent tubes on the reagent tube support, and when medical workers push the sliding bottom plate to enable the axis of the lower leak hole to coincide with the axis of the reagent tubes on the reagent tube support, the reagent tubes leak out from the lower leak hole.
Preferably, the bracket bearing assembly is also included,
the bracket bearing assembly is positioned right below the capsule body supporting assembly and is used for containing the reagent tube bracket;
the support bearing assembly is of a box body structure, the bottom plate is a partition plate, and through holes are densely distributed in the partition plate; the through holes are through holes, the diameter of each through hole is larger than that of the reagent tube, and the through holes correspond to the clamping holes one to one;
the number of the two clamping bag bodies is two, the two clamping bag bodies are only different in height, the two clamping bag bodies are arranged one above the other and fixed together, the clamping bag body positioned at the bottom is shorter, and the thickness after expansion is 0.5-3 cm;
the bracket bearing assembly comprises a bearing plate and a connecting plate;
the bearing plate is fixed on the bag body supporting component through a connecting plate;
the connecting plate plays a role in connection and is fixed at the bottom of the capsule body supporting component or integrally formed with the capsule body supporting component;
the bearing plate plays a role in bearing the reagent tube bracket and is arranged in parallel with the partition plate, and the distance between the bearing plate and the partition plate is greater than the length of the reagent tube; the top of the clamp support body is fixed to the bottom of the bearing plate.
Further, the balloon expansion and contraction assembly comprises a medium input assembly;
the medium input assembly comprises a shell, a piston driving assembly and a conveying pipe;
the conveying pipe is used for communicating the shell with the clamping bag body;
the piston is positioned in the shell in a sliding mode under the driving of the piston driving assembly and is used for conveying the medium of the shell to the interior of the clamping capsule body through the conveying pipe.
Preferably, a preheating assembly for preheating the medium is further arranged inside the housing, and the preheating assembly is in the structure of an electric heating wire.
Preferably, the heating wire is spirally wound on the temperature control column.
Preferably, the number of the heating wires is multiple, and the control unit can control the temperature of different positions of the same clamping device by controlling the number of the heating wires in operation.
One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:
the structure of a clamp device of a clinical primary examination instrument for oncology in the prior art is improved, the clamp device with an elastic bag body as a main body is used for replacing the clamp device with a complex structure, clamping holes for clamping and fixing a reagent tube are densely distributed on the elastic bag body, the clamping holes are through holes, the inner wall of each clamping hole is the outer surface of the elastic bag body, the diameter of each clamping hole is larger than the outer diameter of the reagent tube before the elastic bag body is expanded, and the reagent tube can be fixed by controlling the expansion of the elastic bag body during actual use; the technical problems that in the prior art, a clamp device for clamping a reagent tube by a clinical primary inspection instrument for oncology department is complex in structure, the quantity of the reagent tubes capable of being clamped in a unit area is small, and the manufacturing and later maintenance costs are high are effectively solved; and then realized clinical usefulness of oncology examines the fixture device of instrument simple structure, the volume of the reagent pipe that can the centre gripping in the unit area is big, the manufacturing and later maintenance cost all lower technological effect.
Drawings
FIG. 1 is a schematic view of the overall structure of the clinical primary inspection instrument for oncology according to the present invention;
FIG. 2 is a schematic structural diagram of a holding capsule of the clinical primary examination instrument for oncology according to the present invention;
FIG. 3 is a schematic structural diagram of a balloon expansion and contraction assembly of the clinical primary examination instrument for oncology according to the present invention;
FIG. 4 is a schematic diagram showing the positional relationship between the temperature control column and the capsule supporting member of the clinical primary examination apparatus for oncology of the present invention;
FIG. 5 is a schematic diagram showing the positional relationship between the passage hole and the temperature control column of the clinical primary inspection instrument for oncology;
FIG. 6 is a schematic diagram showing the positional relationship between the holding holes and the insertion holes of the holding capsule of the clinical primary examination apparatus for oncology according to the present invention;
FIG. 7 is a schematic structural diagram of an elastic support body of the clinical primary examination instrument for oncology according to the present invention;
FIG. 8 is a schematic diagram showing the relationship between the temperature control column and the heating wire of the clinical primary inspection instrument for oncology;
FIG. 9 is a schematic structural diagram of a reagent tube holder of the clinical primary inspection instrument for oncology according to the present invention;
FIG. 10 is a schematic bottom view of a reagent tube holder of the clinical primary examination instrument for oncology according to the present invention;
FIG. 11 is a schematic diagram showing the positional relationship between the capsule supporting assembly and the stent carrying assembly of the clinical primary inspection apparatus for oncology department;
fig. 12 is a schematic diagram showing the positional relationship between the holding capsules of the clinical primary examination apparatus for oncology according to the present invention.
In the figure:
a vibration mixing device 100, a clamp support 110;
a capsule supporting assembly 210, a partition 212, a passing hole 213, a stent carrying assembly 220, a carrier plate 221, a connecting plate 222, a clamping capsule 230, a clamping hole 231, a penetration hole 232, a capsule expansion and contraction assembly 240, a medium input assembly 241, a housing 242, a piston 243, a piston driving assembly 244, a preheating assembly 245 and a delivery pipe 246;
a temperature control column 310, an elastic support body 320, a heating wire 330, a first heating wire 331 and a second heating wire 332;
Detailed Description
In order to facilitate an understanding of the present invention, the present application will now be described more fully with reference to the accompanying drawings; the preferred embodiments of the present invention are illustrated in the accompanying drawings, but the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete.
It is noted that the terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; as used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Please refer to fig. 1, which is a schematic diagram of an overall structure of a clinical primary inspection apparatus for oncology according to the present invention; the clinical primary examination instrument for the oncology department comprises a vibration mixing device 100, a clamp device, a power assembly and a control unit; according to the application, the structure of the clamp device of the clinical primary inspection instrument for oncology in the prior art is improved, the clamp device with the main body of the elastic bag body is used for replacing the existing clamp device with a complex structure, clamping holes 231 for clamping and fixing a reagent tube are densely distributed on the elastic bag body, the clamping holes 231 are through holes, the inner wall of each clamping hole 231 is the outer surface of the elastic bag body, the diameter of each clamping hole 231 before the elastic bag body expands is larger than the outer diameter of the reagent tube, and when the clamp device is actually used, the elastic bag body is controlled to expand to fix the reagent tube; the fixture device for the clinical primary examination instrument of the oncology department is simple in structure, the quantity of the reagent tubes capable of being clamped in a unit area is large, and the manufacturing cost and the later maintenance cost are both low.
Example one
As shown in FIG. 1, the clinical primary examination instrument for oncology comprises a vibration mixing device 100, a clamp device, a power assembly and a control unit.
The oscillation mixing device 100 is used for uniformly mixing substances in the reagent tube by shaking the clamp device, a clamp support body 110 with a frame structure or a rod body as a main body is positioned at the top of the oscillation mixing device 100, and the clamp device is fixed at the top of the clamp support body 110; the power assembly is used for providing power for the operation of each part of the primary inspection instrument, and preferably an alternating current power supply or a battery; the control unit plays a role in controlling all parts of the initial inspection instrument to run in a coordinated manner, and is preferably a programmable logic controller; all the prior arts refer to the chinese patent with patent number CN109596406B, and no further description is given here.
The fixture device is used for fixing reagent tubes and comprises a capsule supporting assembly 210, a clamping capsule 230 and a capsule expansion and contraction assembly 240; the capsule supporting assembly 210 is a box structure or a frame structure, and is positioned on the top of the fixture supporting body 110 to fix the clamping capsule 230; the gripping capsule 230 is an elastic capsule, preferably made of rubber, and has a cylindrical or prismatic main body and a plane top; the bottom of the holding capsule 230 is positioned on the capsule supporting assembly 210, and holding holes 231 are densely distributed on the holding capsule 230; as shown in fig. 2 and 3, the axial direction of the clamping hole 231 is the same as the height direction of the clamping capsule 230, and is a through hole, the clamping hole 231 is not communicated with the inner space of the clamping capsule 230 (i.e. the inner wall of the clamping hole 231 is the outer surface of the clamping capsule 230), and the diameter of the clamping hole 231 is larger than the diameter of the reagent tube before the clamping capsule 230 is expanded; the balloon inflation and deflation assembly 240 functions to control the inflation and deflation of the gripping balloon 230 by controlling the amount of the substance (gas and/or liquid) inside the gripping balloon 230, and is preferably configured as a pump, which is controlled by the control unit to operate.
Further, as shown in fig. 3, the balloon expansion and contraction assembly 240 includes a medium input assembly 241; the media input assembly 241 includes a housing 242, a plunger 243, a plunger drive assembly 244, and a delivery tube 246; the delivery tube 246 communicates the housing 242 with the gripping capsule 230; the piston 243 is slidably positioned in the housing 242 by the driving of the piston driving assembly 244, and the piston 243 is used for conveying the medium of the housing 242 to the interior of the clamping capsule 230 through the conveying pipe 246.
Further, as shown in fig. 4, the bladder support assembly 210 is a box body with an open top;
when the device is actually used, the clamping capsule body 230 is in a contracted state in an initial state, medical personnel insert the reagent tubes into the clamping holes 231 one by one, and then control the clamping capsule body 230 to expand to fix the reagent tubes; after mixing, the clamping capsule 230 is controlled to contract, and the medical staff takes out the reagent tubes one by one.
The medical staff judges the detection result by observing the color of the reagent in the reagent tube, or puts the reagent tube taken out into the relevant equipment based on image color information acquisition and processing to judge and output the detection result; the device for collecting and processing image color information is the prior art, and is not described herein again. The technical scheme in the embodiment of the application at least has the following technical effects or advantages:
the technical problems that in the prior art, a clamp device for clamping a reagent tube by an oncology clinical primary inspection instrument is complex in structure, the quantity of the reagent tubes capable of being clamped in a unit area is small, and the manufacturing and later maintenance costs are high are solved; the fixture device for the clinical primary examination instrument for the oncology department is simple in structure, the quantity of the reagent tubes capable of being clamped in a unit area is large, and the manufacturing cost and the later maintenance cost are both low.
Example two
In consideration of the fact that different reagents are required to be selected for use in detection of different diseases in actual work, different reagents have different reaction temperatures, in the scheme of the embodiment, although a large number of reagents can be mixed at one time, the reagent kit can not be suitable for mixing multiple reagents with different requirements for temperature at one time, and in order to further improve the practicability of the clinical primary inspection instrument for oncology department, the medium temperature control assembly is additionally arranged on the basis of the embodiment, and different temperatures of different positions of the same clamp device are different in a heating mode by dividing regions.
Preferably, as shown in fig. 5 and 6, the holding capsule 230 is further positioned with through holes 232, the through holes 232 are densely distributed on the holding capsule 230, the axes of the through holes 232 are parallel to the axes of the holding holes 231, and the holding holes 231 are not communicated with the inner space of the holding capsule 230; the penetration hole 232 is matched with the medium temperature control component, and controls the temperature of the clamping bag body 230 and the temperature of the medium in the clamping bag body 230 in a heating mode; the medium temperature control assembly comprises a temperature control column 310, the temperature control column 310 is cylindrical and is densely distributed on the upper surface of the capsule body supporting assembly 210 and is inserted into the through hole 232, and the temperature control columns 310 correspond to the through holes 232 one by one and are distributed on the periphery of the clamping hole 231; the surface of the temperature control column 310 is densely provided with electric heating plates or heating wires 330 (electric heating wires) which operate under the control of the control unit.
Preferably, the medium temperature control assembly comprises a temperature control column 310, wherein the temperature control column 310 is cylindrical, is positioned inside the clamping capsule body 230, is provided with a plurality of columns, has the same axial direction as the clamping hole 231, and is distributed around the clamping hole 231; the surface of the temperature control column 310 is densely provided with electric heating plates or heating wires 330 (electric heating wires) which operate under the control of the control unit.
Preferably, the heating wire 330 is spirally wound around the temperature control column 310.
Further, the heating wires 330 are spirally wound on the temperature control column 310, the number of the heating wires is multiple, and the control unit can control the temperature of different positions of the same clamping device by controlling the number of the heating wires 330.
Further, as shown in fig. 8, the heating wire 330 includes a first heating wire 331 and a second heating wire 332; the first heating wire 331 and the second heating wire 332 are spirally wound on the temperature control column 310, and the distance between the first heating wire 331 and the second heating wire 332 is 2-5 mm.
Preferably, as shown in fig. 7, the medium temperature control assembly includes an elastic supporter 320 and a heating wire 330; the elastic support body 320 has a spring structure to support the heating wire 330, and two ends of the elastic support body are fixed inside the holding bag body 230, and the elastic support body is provided with a plurality of holding holes 231 corresponding to the holding holes one by one; the axis of the elastic support 320 coincides with the axis of the clamping hole 231; the heating wire 330 is an electric heating wire, is positioned on the elastic supporting body 320, and operates under the control of a control unit.
To facilitate the transfer of heat, it is preferable that the medium inside the clamping bladder 230 is water.
Preferably, as shown in fig. 3, a preheating assembly 245 for preheating the medium is further provided inside the housing 242, and the preheating assembly 245 is configured as an electric heating wire.
EXAMPLE III
In view of the above, the process of placing the reagent tubes into the holding capsule 230 one by one and taking the reagent tubes out of the holding capsule 230 one by one is tedious, and has a certain labor intensity; in view of the above problems, the embodiment of the present application is configured with a dedicated reagent tube stent 400 for the clamping capsule 230 on the basis of the above embodiments, and is further provided with a stent bearing assembly 220, specifically:
as shown in fig. 9 and 10, the reagent vessel support 400 includes a support frame 410, a stopper piece 420, and a slide bottom plate 430; the supporting frame 410 is a frame structure, and plays a role in supporting and positioning the limiting piece 420; the limiting sheet 420 is used for limiting the spatial position of each reagent tube on the reagent tube holder 400, and the structure is preferably a combination of a plurality of wave-shaped strips as shown in fig. 9; the sliding bottom plate 430 is plate-shaped, is slidably positioned on the supporting frame 410 and is located below the limiting piece 420, and the sliding direction is perpendicular to the height direction of the supporting frame 410; the sliding bottom plate 430 is densely provided with lower leakage holes 431; the lower leakage holes 431 are through holes, correspond to the reagent tubes on the reagent tube support 400 one by one, and are positioned right below the reagent tubes on the reagent tube support 400, the diameter of the lower leakage holes 431 is slightly larger (not more than 5 mm) than that of the reagent tubes, the sliding bottom plate 430 plays a supporting role for the reagent tubes on the reagent tube support 400, and when the medical staff pushes the sliding bottom plate 430 to enable the axis of the lower leakage holes 431 to coincide with the axis of the reagent tubes on the reagent tube support 400, the reagent tubes leak out of the lower leakage holes 431;
as shown in fig. 11, the stent carrier assembly 220 is positioned directly below the capsule support assembly 210 for holding the reagent tube stent 400; the bracket bearing assembly 220 is of a box structure, the bottom plate is a partition plate 212, and through holes 213 are densely distributed in the partition plate 212; the through holes 213 are through holes, the diameter of each through hole is slightly larger than (not more than 5 mm) that of the reagent tube, and the through holes correspond to the clamping holes 231 one by one;
as shown in fig. 12, the number of the holding bladders 230 is two, the two holding bladders 230 have different heights, the two holding bladders 230 are arranged one above the other and fixed together, the holding bladder 230 at the bottom is shorter, and the inflated thickness is 0.5 to 3 cm;
as shown in fig. 11, the rack bearing assembly 220 includes a bearing plate 221 and a connection plate 222; the carrier plate 221 is fixed to the capsule supporting assembly 210 by a connecting plate 222; the connecting plate 222 is used for connecting and is fixed at the bottom of the capsule supporting assembly 210 or is integrally formed with the capsule supporting assembly 210; the carrier plate 221 serves to carry the reagent tube holder 400, and is disposed parallel to the partition plate 212, with a distance therebetween greater than the length of the reagent tube; the top of the clamp supporter 110 is fixed to the bottom of the loading plate 221.
Preferably, a limiting groove is further disposed on the upper surface of the carrier plate 221, and the limiting groove is used for limiting the position of the reagent tube holder 400 on the carrier plate 221 so that the reagent tubes on the clamping holes 231 can be conveniently placed on the reagent tube holder 400.
When the reagent bottle is used, a medical worker places the reagent bottle holder 400 containing the reagent bottle right above the holding bag body 230, and the lower leakage holes 431 are in one-to-one correspondence with the holding holes 231; then controlling the clamping capsule 230 at the bottom to expand by a certain amount to ensure that the reagent tube does not leak out of the clamping hole 231 of the clamping capsule 230; meanwhile, the holding capsule 230 at the top is controlled to expand by a certain amount, so that the minimum diameter of the holding hole 231 on the holding capsule 230 is slightly smaller than or equal to the diameter of the reagent tube (i.e. smaller than the diameter of the reagent tube by 5 mm), and the specific amount is determined according to actual requirements; thereafter, the sliding bottom plate 430 is pushed or pulled to cause the reagent tube (under the multiple actions of its own weight, the friction between the reagent tube and the holding capsule 230, and the elastic force of the holding capsule 230) to slowly fall into the holding hole 231; controlling the clamping bladder 230 to expand for mixing of the reagents; after mixing, the empty reagent tube holder 400 is placed on the carrier plate 221, and then the two holding capsules 230 are controlled to contract by a certain amount, so that the reagent tubes slowly fall into the reagent tube storage positions on the reagent tube holder 400 under the influence of gravity.
Preferably, the device based on image color information acquisition processing is positioned on the support bearing assembly 220, and is used for acquiring image color information to further determine the detection result.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. An oncology clinical primary examination instrument comprises a vibration mixing device (100), a clamp device, a power assembly and a control unit, wherein the vibration mixing device (100) is used for mixing substances in a reagent tube in a mode of shaking the clamp device, a clamp supporting body (110) with a frame structure or a rod body as a main body is positioned at the top of the vibration mixing device (100), and the clamp device is fixed at the top of the clamp supporting body (110); the fixture device is characterized by comprising a capsule supporting assembly (210), a clamping capsule (230) and a capsule expansion and contraction assembly (240);
the bladder support assembly (210) is a box structure or a frame structure, positioned on top of the clamp support (110);
the clamping capsule body (230) is an elastic capsule body, and the main body is cylindrical or prismatic;
the bottom of the clamping capsule body (230) is positioned on the capsule body supporting assembly (210), clamping holes (231) are densely distributed in the clamping capsule body (230), the axial direction of the clamping holes (231) is the same as the height direction of the clamping capsule body (230) and is a through hole, the clamping holes (231) are not communicated with the inner space of the clamping capsule body (230), and the diameter of the clamping holes (231) is larger than that of the reagent tube before the clamping capsule body (230) is expanded;
the balloon expansion and contraction assembly (240) is used for controlling the clamping balloon (230) to expand and contract and is a pump;
the clamping capsule body (230) is matched with a special reagent tube bracket (400);
the reagent tube bracket (400) comprises a supporting frame (410), a limiting sheet (420) and a sliding bottom plate (430);
the supporting frame (410) is used for supporting the limiting sheet (420); the limiting sheet (420) is used for limiting the spatial position of each reagent tube on the reagent tube bracket (400);
the sliding bottom plate (430) is plate-shaped, is positioned on the supporting frame (410) in a sliding manner and is positioned below the limiting sheet (420), and the sliding direction is vertical to the height direction of the supporting frame (410);
the sliding bottom plate (430) is densely provided with lower leakage holes (431); the lower leakage holes (431) are through holes, correspond to the reagent tubes on the reagent tube support (400) one by one, are positioned right below the reagent tubes on the reagent tube support (400), the diameter of the lower leakage holes (431) is larger than that of the reagent tubes, the sliding bottom plate (430) plays a supporting role for the reagent tubes on the reagent tube support (400), and when the medical staff pushes the sliding bottom plate (430) to enable the axis of the lower leakage holes (431) to coincide with the axis of the reagent tubes on the reagent tube support (400), the reagent tubes leak out of the lower leakage holes (431);
also comprises a bracket bearing component (220),
the stent carrier assembly (220) is positioned right below the capsule supporting assembly (210) and is used for containing the reagent tube stent (400);
the support bearing assembly (220) is of a box structure, the bottom plate is a partition plate (212), and through holes (213) are densely distributed in the partition plate (212); the through holes (213) are through holes, the diameter of each through hole is larger than that of the reagent tube, and the through holes correspond to the clamping holes (231) one by one;
the number of the clamping capsules (230) is two, the two clamping capsules (230) are only different in height, the two clamping capsules (230) are arranged one above the other and fixed together, the clamping capsule (230) positioned at the bottom is shorter, and the thickness after expansion is 0.5-3 cm;
the bracket bearing assembly (220) comprises a bearing plate (221) and a connecting plate (222);
the bearing plate (221) is fixed on the capsule supporting assembly (210) through a connecting plate (222);
the connecting plate (222) is used for connecting and is fixed at the bottom of the capsule supporting component (210) or is integrally formed with the capsule supporting component (210);
the bearing plate (221) plays a role of bearing the reagent tube bracket (400), is arranged in parallel with the partition plate (212), and the distance between the bearing plate and the partition plate is greater than the length of the reagent tube; the top of the clamp support body (110) is fixed at the bottom of the bearing plate (221);
the device also comprises a medium temperature control component;
the medium temperature control component comprises an elastic support body (320) and a heating wire (330);
the elastic supporting body (320) is of a spring structure and plays a role in supporting the heating wires (330), two ends of the elastic supporting body are fixed inside the clamping capsule body (230), and the elastic supporting body is provided with a plurality of clamping holes (231) which correspond to the clamping holes one by one;
the axis of the elastic support body (320) is coincident with the axis of the clamping hole (231);
the heating wire (330) is an electric heating wire, is positioned on the elastic supporting body (320), and operates under the control of a control unit; a preheating assembly (245) for preheating the medium is further arranged inside the shell (242), and the preheating assembly (245) is structurally an electric heating wire.
2. The clinical primary screening instrument for oncology department according to claim 1, further comprising a media temperature control assembly;
the clamping capsule body (230) is also provided with through holes (232), the through holes (232) are densely distributed on the clamping capsule body (230), the axial line of the through holes (232) is parallel to the axial line of the clamping holes (231), and the clamping holes (231) are not communicated with the inner space of the clamping capsule body (230);
the medium temperature control assembly comprises temperature control columns (310), the temperature control columns (310) are cylindrical and are densely distributed on the upper surface of the capsule body supporting assembly (210) and inserted into the penetrating holes (232), and the temperature control columns (310) correspond to the penetrating holes (232) one by one and are distributed on the periphery of the clamping holes (231); the surface of the temperature control column (310) is densely distributed with electric heating sheets or heating wires (330) and operates under the control of the control unit.
3. The clinical primary examination instrument for oncology department according to claim 1, further comprising a medium temperature control assembly, the medium temperature control assembly comprising a temperature control column (310);
the temperature control columns (310) are cylindrical, are positioned inside the clamping capsule bodies (230), are multiple in number, have the same axial direction as the clamping holes (231), and are distributed on the periphery of the clamping holes (231);
the surface of the temperature control column (310) is densely distributed with electric heating sheets or heating wires (330) and operates under the control of the control unit.
4. The clinical examination apparatus for clinical oncology according to any one of claims 1 to 3, wherein the balloon expansion and contraction assembly (240) comprises a medium input assembly (241);
the media input assembly (241) includes a housing (242), a plunger (243), a plunger drive assembly (244), and a delivery tube (246);
the delivery tube (246) communicating the housing (242) with the gripping capsule (230);
the piston (243) is slidably positioned in the housing (242) under the driving of a piston driving assembly (244), and the piston (243) is used for conveying the medium of the housing (242) to the interior of the clamping capsule (230) through a conveying pipe (246).
5. The clinical primary examination instrument for oncology department according to claim 2 or 3, wherein the heating wire (330) is spirally wound around the temperature control column (310).
6. The clinical preliminary examination apparatus for oncology according to claim 5, wherein the number of the heating wires (330) is plural, and the control unit is capable of controlling the temperature of the same fixture device at different positions by controlling the number of the operation of the heating wires (330).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210525757.7A CN114602361B (en) | 2022-05-16 | 2022-05-16 | Clinical instrument of examining of oncology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210525757.7A CN114602361B (en) | 2022-05-16 | 2022-05-16 | Clinical instrument of examining of oncology |
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| CN114602361A CN114602361A (en) | 2022-06-10 |
| CN114602361B true CN114602361B (en) | 2022-08-26 |
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| CN202210525757.7A Expired - Fee Related CN114602361B (en) | 2022-05-16 | 2022-05-16 | Clinical instrument of examining of oncology |
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| US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
| CN109596406A (en) * | 2019-02-15 | 2019-04-09 | 孙驰南 | A kind of first test examination instrument of oncology clinic |
| CN210206949U (en) * | 2019-07-05 | 2020-03-31 | 谭珊 | Test-tube rack that clinical laboratory used |
| CN214361359U (en) * | 2020-10-19 | 2021-10-08 | 大连海关技术中心 | Multiplex real-time fluorescence PCR detection kit |
| CN214357533U (en) * | 2020-12-03 | 2021-10-08 | 西安博天生物工程有限公司 | Kit for detecting antibody |
| CN215029166U (en) * | 2021-06-05 | 2021-12-07 | 深圳市华瑞康生物科技有限公司 | Nucleic acid sampling pipe carrier |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215376A (en) * | 1989-09-08 | 1993-06-01 | Becton, Dickinson And Company | Method for causing vortices in a test tube |
| CN208865557U (en) * | 2018-09-28 | 2019-05-17 | 南京林业大学 | Reagent shakes bracket |
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2022
- 2022-05-16 CN CN202210525757.7A patent/CN114602361B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
| CN109596406A (en) * | 2019-02-15 | 2019-04-09 | 孙驰南 | A kind of first test examination instrument of oncology clinic |
| CN210206949U (en) * | 2019-07-05 | 2020-03-31 | 谭珊 | Test-tube rack that clinical laboratory used |
| CN214361359U (en) * | 2020-10-19 | 2021-10-08 | 大连海关技术中心 | Multiplex real-time fluorescence PCR detection kit |
| CN214357533U (en) * | 2020-12-03 | 2021-10-08 | 西安博天生物工程有限公司 | Kit for detecting antibody |
| CN215029166U (en) * | 2021-06-05 | 2021-12-07 | 深圳市华瑞康生物科技有限公司 | Nucleic acid sampling pipe carrier |
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| CN114602361A (en) | 2022-06-10 |
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