CN114569084A - Brain function imaging method and system with visual and custom-arranged channels - Google Patents
Brain function imaging method and system with visual and custom-arranged channels Download PDFInfo
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- 230000003925 brain function Effects 0.000 title claims abstract description 37
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- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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Abstract
The invention discloses a brain function imaging method with visual and custom-arranged channels, which comprises the following steps: a, establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model through software; b, matching the grid graph with a fiber cap model; c, performing self-defined channel arrangement on the grid map according to brain function detection requirements, and mapping channel arrangement data to a 3D head model for visual display; d, judging whether the channel arrangement needs to be adjusted, and if so, returning to the step c; if not, sending the channel arrangement data to a lower computer; and e, the lower computer controls the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data to obtain imaging data meeting the brain function detection requirement. According to the invention, the channel arrangement grid graph is established, and the grid graph is matched with the fiber cap model, so that the channel arrangement can be defined on the grid graph in a user-defined manner, the channel arrangement condition can be adjusted rapidly and accurately, and the actual requirement is met.
Description
Technical Field
The invention belongs to the technical field of near-infrared brain function imaging, and particularly relates to a brain function imaging method and system with visual and custom-arranged channels.
Background
As a representative of brain function imaging technologies, functional magnetic resonance imaging (fMRI), Positron Emission Tomography (PET), electroencephalogram (EEG), and other technologies play an important role in the field of brain function research and diagnosis and treatment of brain diseases, but the application of these technologies is limited due to the high cost, low time resolution, the limited requirements on the subject or patient, and possible side effects. Near infrared spectroscopy imaging (NIRS) is an important component of brain function imaging technology with the advantages of low cost, high temporal resolution, no side effects, no restrictions on the subject or patient, etc.
The near infrared spectral imaging technology has been developed earlier abroad, and there are more mature products such as ETG series of Hitachi, Japan, FOIRE series of Shimadzu, and CW series of Techen, USA. The related technology in China is relatively laggard, and no mature product exists.
Chinese patent publication No. CN103156620A discloses a multi-channel parallel near infrared spectral imaging system, which uses a multi-wavelength LED to complete the emission of near infrared light, an avalanche photodiode to detect weak light signals, and an analog lock-in amplifier technology to realize signal amplification, and can use the near infrared spectral computer function imaging helmet disclosed in chinese patent application CN200520002784.8 to improve the unreasonable design of the adaptive head part. The multichannel parallel near infrared spectrum imaging system can continuously, quickly and accurately detect and collect cerebral blood oxygen signals, overcomes the defects of the existing functional near infrared system, and truly exerts the advantages of the functional near infrared spectrum imaging technology relative to other brain function imaging technologies. Although the near infrared spectrum imaging system of the above patent can complete the blood oxygen information detection, the following defects still exist: different research subjects or brain function detection needs need to observe the brain area functions of different parts through near-infrared equipment, different brain areas need different channel arrangements, and the above-mentioned patent can not realize highly free visual channel arrangement, when needing to detect different brain area functions, can not visual self-defined adjustment, and the channel arrangement is more troublesome.
Therefore, it is desirable to provide a method and a system for brain function imaging with channel visualization customized arrangement to solve the above technical problems.
Disclosure of Invention
The invention aims to provide a brain function imaging method and system with visual and custom-arranged channels, aiming at the problems in the prior art.
In order to achieve the purpose, the invention adopts the technical scheme that:
a brain function imaging method with visual and custom-arranged channels comprises the following steps:
a, establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model matched with the 3D head model through software;
b, matching the grid graph with a fiber cap model;
c, performing self-defined channel arrangement on the grid map according to brain function detection requirements, and mapping channel arrangement data to a 3D head model for visual display;
d, judging whether the channel arrangement needs to be adjusted, and if so, returning to the step c; if not, sending the channel arrangement data to a lower computer;
and e, the lower computer controls the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data to obtain imaging data meeting the brain function detection requirement.
According to the invention, the channel arrangement can be defined on the grid map by establishing the channel arrangement grid map and matching the grid map with the fiber cap model; and the channel arrangement data are mapped to the 3D head model for visual display, so that the channel arrangement can be conveniently and visually adjusted, the channel arrangement condition can be rapidly and accurately adjusted, and the actual research or detection requirements are met.
Specifically, in step a, the grid point distribution in the grid map corresponds to the probe distribution on the fiber cap, that is, each grid point position in the grid map corresponds to one probe position on the fiber cap.
Specifically, in the step b, mapping the position information of each probe on the optical fiber cap to each corresponding grid point on the grid map, wherein the position information of each probe on the optical fiber cap is matched with the position information of the corresponding part on the 3D head model; when the transmitting probe or the receiving probe is placed on a certain grid point in the grid diagram, the transmitting probe or the receiving probe corresponding to the position of the grid point on the optical fiber cap is opened.
Specifically, in step c, the channel arrangement data includes: the number and position information of the transmitting probes and the receiving probes on the grid map; after the positions and the number of the transmitting probes and the receiving probes are arranged in a user-defined manner in the grid diagram, the transmitting probes and the receiving probes are matched with the grid positions on the optical fiber cap and are opened, and a detecting optical signal receiving and transmitting channel is formed; because the position information of the 3D head model is matched with the position information of the optical fiber cap model, after the positions and the number of the transmitting probes and the receiving probes are configured in the grid diagram, the optical signal receiving and transmitting channels can be correspondingly displayed on the 3D head model, namely the number and the positions of the transmitting probes and the receiving probes can be displayed on the 3D head model, the visual display of the detecting optical signal receiving and transmitting channels is realized, and the arrangement of the channels is convenient to adjust.
Specifically, in step d, the basis for determining whether the channel arrangement needs to be adjusted is: whether the current channel arrangement meets the requirements for detecting or researching the brain region functional imaging position; if the specific brain region part cannot be detected by the current channel arrangement, the channel arrangement needs to be adjusted, and the channel arrangement condition on the 3D head model can be observed while adjusting.
In step e, the lower computer controls the transmitting probes and the receiving probes at various positions on the optical fiber cap to be opened and closed, so that channel arrangement can be adjusted quickly, and channel adjustment efficiency is improved.
Corresponding to the brain function imaging method for the visual self-defined arrangement of the channels, the invention also provides a brain function imaging system for the visual self-defined arrangement of the channels, which comprises an upper computer, a lower computer and an optical fiber cap which are sequentially connected;
the upper computer is used for establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model, and performing custom channel arrangement and visual display of channel arrangement;
the lower computer is used for controlling the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data;
a plurality of transmitting probes and a plurality of receiving probes are arranged at intervals on the inner side of the optical fiber cap, and the transmitting probes and the receiving probes are electrically connected with a lower computer respectively;
the lower computer controls a receiving probe and a transmitting probe at corresponding positions on the optical fiber cap to work according to channel arrangement data issued by the upper computer, a detection light signal sent by the transmitting probe is received by the receiving probe after being reflected by cerebral cortex, the receiving probe converts a received spectrum signal into an electric signal and transmits the electric signal to the lower computer, the lower computer uploads the electric signal to the upper computer, and the upper computer performs a series of digital filtering sampling reduction processing on the transmitted electric signal to obtain brain function imaging data of a detected object.
According to the invention, the emission of the detection light and the reception of the spectrum signal are integrated in the probe of the optical fiber cap, an electric signal transmission mode is adopted to replace an optical signal transmission mode, and an optical fiber is not required to be connected on the probe, so that the wearing burden of a user is reduced, and the experience feeling is improved.
Specifically, the transmitting probe and the receiving probe adopt coupling type optical transceiving probes with completely same structures;
the optical transceiving probe is used for transmitting a detection light signal to the cerebral cortex or receiving a spectrum signal reflected back by the cerebral cortex;
and the lower computer is used for controlling and switching the working mode of the optical transceiving probe.
Further, the optical transceiver probe includes:
at least two light emitting units for emitting probe light signals of a plurality of wavelengths;
the light receiving unit is used for receiving the spectral signals reflected back through the cerebral cortex;
a housing for enclosing the light emitting unit and the light receiving unit;
and one end of the shell is provided with an inlet and an outlet for the light signal to enter and exit.
Furthermore, the two light emitting units are respectively and obliquely arranged on two opposite side walls of the shell, two reflectors are further arranged on the two opposite side walls of the shell, the reflecting surfaces of the two reflectors respectively correspond to the light emitting directions of the two light emitting units, and the reflectors are used for guiding the detection light emitted by the light emitting units out of the inlet and the outlet of the shell; the light receiving unit is installed at one end of the shell far away from the inlet and the outlet. The design can further reduce the volume of the probe, so that the integration of the probe is more compact and the probe is convenient to install on the optical fiber cap.
Further, the working modes of the optical transceiving probe comprise a transmitting mode and a receiving mode;
when the light emitting unit is switched to the emitting mode, the light receiving unit stops working, and the light emitting unit works normally;
when the receiving mode is switched, the light emitting unit stops working, and the light receiving unit works normally.
Compared with the prior art, the invention has the beneficial effects that: (1) according to the invention, the channel arrangement can be defined on the grid map by establishing the channel arrangement grid map and matching the grid map with the fiber cap model; the channel arrangement data are mapped to the 3D head model for visual display, so that the channel arrangement can be conveniently and visually adjusted, the channel arrangement condition can be rapidly and accurately adjusted, and the actual research or detection requirements are met; (2) according to the invention, the emission of the detection light and the reception of the spectrum signal are integrated in the probe of the optical fiber cap, and an electric signal transmission mode is adopted to replace an optical signal transmission mode, so that an optical fiber is not required to be connected to the probe, the wearing burden of a user is reduced, and the experience feeling is improved; (3) the optical transceiving probe can be used as a transmitting probe and a receiving probe, and can be arranged in a user-defined mode according to actual requirements in the specific using process, so that the efficiency of channel adjustment is improved.
Drawings
Fig. 1 is a schematic flow chart of a brain function imaging method with visual custom arrangement of channels according to embodiment 1 of the present invention.
Fig. 2 is a schematic diagram of a grid diagram of channel arrangement in embodiment 1 of the present invention.
Fig. 3 is a schematic diagram illustrating an effect of arranging the transmitting probes and the receiving probes on the grid map in embodiment 1 of the present invention.
Fig. 4 is a schematic diagram of an internal optical path when the optical transceiver probe is switched to the transmission mode in embodiment 2 of the present invention.
Fig. 5 is a schematic diagram of an internal optical path when the optical transceiver probe is switched to the receiving mode in embodiment 2 of the present invention.
In the figure: 1. a housing; 2. a light receiving unit; 3. a light emitting unit; 4. a mirror; 5. and (7) an inlet and an outlet.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
As shown in fig. 1, the present embodiment provides a brain function imaging method with a visual custom arrangement of channels, which includes the following steps:
a, establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model matched with the 3D head model through 3D software (the 3D software is installed on an upper computer);
b, matching the grid graph with a fiber cap model;
c, performing self-defined channel arrangement on the grid map according to brain function detection requirements, and mapping channel arrangement data to a 3D head model for visual display;
d, judging whether the channel arrangement needs to be adjusted, and if so, returning to the step c; if not, sending the channel arrangement data to a lower computer;
and e, the lower computer controls the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data to obtain imaging data meeting the brain function detection requirement.
According to the invention, the channel arrangement can be defined on the grid map by establishing the channel arrangement grid map and matching the grid map with the fiber cap model; and the channel arrangement data are mapped to the 3D head model for visual display, so that the channel arrangement can be conveniently and visually adjusted, the channel arrangement condition can be rapidly and accurately adjusted, and the actual research or detection requirements are met.
Specifically, as shown in fig. 2, in step a, the grid point distribution in the grid map corresponds to the probe distribution on the fiber cap, that is, each grid point position in the grid map corresponds to one probe position on the fiber cap.
Specifically, in the step b, mapping the position information of each probe on the optical fiber cap to each corresponding grid point on the grid map, wherein the position information of each probe on the optical fiber cap is matched with the position information of the corresponding part on the 3D head model; when the transmitting probe or the receiving probe is placed on a certain grid point in the grid diagram, the transmitting probe or the receiving probe corresponding to the position of the grid point on the optical fiber cap is opened.
Specifically, in step c, the channel arrangement data includes: the number and position information of the transmitting probes and the receiving probes on the grid map; after the positions and the number of the transmitting probes and the receiving probes are arranged in a user-defined manner in the grid diagram, the transmitting probes and the receiving probes are matched with the grid positions on the optical fiber cap and are opened, and a detecting optical signal receiving and transmitting channel is formed; because the position information of the 3D head model is matched with that of the optical fiber cap model, after the positions and the number of the transmitting probes and the receiving probes are configured in the grid diagram, the optical signal transceiving channels can be correspondingly displayed on the 3D head model, namely, the number and the positions of the transmitting probes and the receiving probes can be displayed on the 3D head model, the visual display of the detecting optical signal transceiving channels is realized, and the arrangement of the channels is convenient to adjust.
Specifically, in step d, the basis for determining whether the channel arrangement needs to be adjusted is: whether the current channel arrangement meets the requirements for detecting or researching the brain region functional imaging position; if the specific brain region part cannot be detected by the current channel arrangement, the channel arrangement needs to be adjusted, and the channel arrangement condition on the 3D head model can be observed while adjusting.
In step e, the lower computer controls the transmitting probes and the receiving probes at various positions on the optical fiber cap to be opened and closed, so that channel arrangement can be adjusted quickly, and channel adjustment efficiency is improved.
As shown in fig. 3, S1(0, 2), S2(2, 0), S3(0, -2), S4(-2, 0) in the grid map are the positions of the customized 4 transmitting probes, and D1(0, 0) is the position of the customized 1 receiving probe; in the specific implementation process, the number and the positions of the transmitting probes and the receiving probes can be adjusted according to actual requirements, and the positions of S1, S2, S3, S4 and D1 are directly dragged in the grid diagram, so that the channel arrangement can be adjusted; or adding more transmitting probes (S5, S6 and the like) and receiving probes (D2, D3 and the like) to adjust the channel arrangement.
Example 2
As shown in the figure, the embodiment provides a brain function imaging system with visual and custom-arranged channels, which comprises an upper computer, a lower computer and an optical fiber cap, which are sequentially connected;
the upper computer is used for establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model, and performing custom channel arrangement and visual display of channel arrangement;
the lower computer is used for controlling the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data;
a plurality of transmitting probes and a plurality of receiving probes are arranged on the inner side of the optical fiber cap at intervals, and the transmitting probes and the receiving probes are electrically connected with a lower computer respectively;
the lower computer controls a receiving probe and a transmitting probe at corresponding positions on the optical fiber cap to work according to channel arrangement data issued by the upper computer, a detection light signal sent by the transmitting probe is received by the receiving probe after being reflected by cerebral cortex, the receiving probe converts a received spectrum signal into an electric signal and transmits the electric signal to the lower computer, the lower computer uploads the electric signal to the upper computer, and the upper computer performs a series of digital filtering sampling reduction processing on the transmitted electric signal to obtain brain function imaging data of a detected object. In this embodiment, the upper computer is a computer, and the lower computer is a controller.
This embodiment is through the transmission with the probe light and the receiving integration of spectral signal in the probe of optic fibre cap, adopts electrical signal transmission's mode to replace light signal transmission's mode, need not to connect optic fibre on the probe, has alleviateed the burden that the user wore, has promoted experience and has felt.
Specifically, the transmitting probe and the receiving probe adopt coupling type optical transceiving probes with completely same structures;
the optical transceiving probe is used for transmitting a detection light signal to the cerebral cortex or receiving a spectrum signal reflected back by the cerebral cortex;
and the lower computer is used for controlling and switching the working mode of the optical transceiving probe.
Further, the optical transceiving probe comprises:
two light emitting units 3 for emitting probe light signals of a plurality of wavelengths;
the light receiving unit 2 is used for receiving the spectral signals reflected by the cerebral cortex;
a housing 1 for enclosing the light emitting unit 3 and the light receiving unit 2;
an inlet and an outlet 5 are arranged at one end of the shell 1 and used for the entrance and exit of optical signals.
Furthermore, the two light emitting units 3 are respectively and obliquely installed on two opposite side walls of the housing 1, two reflectors 4 are further arranged on the two opposite side walls of the housing 1, the reflecting surfaces of the two reflectors 4 respectively correspond to the light emitting directions of the two light emitting units 3, and the reflectors 4 are used for guiding the detection light emitted by the light emitting units 3 out of the inlet and outlet 5 of the housing 1; the light receiving unit 2 is mounted at one end of the housing 1 far away from the inlet/outlet 5. The design can further reduce the volume of the probe, so that the integration of the probe is more compact and the probe is convenient to install on the optical fiber cap.
Further, the working modes of the optical transceiving probe comprise a transmitting mode and a receiving mode;
as shown in fig. 4, when the transmission mode is switched, the light receiving unit 2 stops operating, and the light emitting unit 3 operates normally;
as shown in fig. 5, when the receiving mode is switched, the light emitting unit 3 stops operating and the light receiving unit 2 operates normally.
Specifically, the light emitting unit 3 employs a laser diode, which has the advantages of small volume, light weight, low power consumption, simple driving circuit, convenient modulation, mechanical shock resistance, vibration resistance, and the like.
In this embodiment, the wavelengths of the two laser diodes are 690nm and 830nm, respectively.
Specifically, the light receiving unit 2 adopts an avalanche photodiode, and compared with a vacuum photomultiplier, the avalanche photodiode has the advantages of small volume, no need of a high-voltage power supply and the like, and is more suitable for practical application; compared with a common semiconductor photodiode, the avalanche photodiode has the advantages of high sensitivity, high speed and the like, and particularly when the system bandwidth is large, the detection performance of the system can be greatly improved.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A brain function imaging method with visual and custom-arranged channels is characterized by comprising the following steps:
a, establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model matched with the 3D head model through software;
b, matching the grid graph with a fiber cap model;
c, performing self-defined channel arrangement on the grid map according to brain function detection requirements, and mapping channel arrangement data to a 3D head model for visual display;
d, judging whether the channel arrangement needs to be adjusted, and if so, returning to the step c; if not, sending the channel arrangement data to a lower computer;
and e, the lower computer controls the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data to obtain imaging data meeting the brain function detection requirement.
2. The method for brain function imaging with channel visualization customized arrangement according to claim 1, wherein in step a, the distribution of grid points in the grid map corresponds to the distribution of probes on the fiber cap.
3. The method for brain function imaging with visual custom arrangement of channels according to claim 1, wherein in step b, the position information of each probe on the fiber cap is mapped to each corresponding grid point on the grid map, and the position information of each probe on the fiber cap is matched with the position information of the corresponding part on the 3D head model.
4. The method for brain function imaging with channel visualization customized arrangement according to claim 1, wherein in step c, the channel arrangement data includes: and the quantity and position information of the transmitting probes and the receiving probes on the grid map.
5. A brain function imaging system with visual and custom-arranged channels is based on the brain function imaging method with visual and custom-arranged channels according to any one of claims 1 to 4, and is characterized by comprising an upper computer, a lower computer and an optical fiber cap which are sequentially connected;
the upper computer is used for establishing a channel arrangement grid diagram, a 3D head model and a fiber cap model, and performing custom channel arrangement and visual display of channel arrangement;
the lower computer is used for controlling the opening of the channel at the corresponding position on the optical fiber cap according to the channel arrangement data;
the optical fiber cap is characterized in that a plurality of transmitting probes and a plurality of receiving probes are arranged on the inner side of the optical fiber cap at intervals, and the transmitting probes and the receiving probes are electrically connected with a lower computer respectively.
6. The brain function imaging system with the visual self-defined arrangement of the channels as claimed in claim 5, wherein the transmitting probe and the receiving probe adopt coupling type optical transceiving probes with completely identical structures;
the optical transceiving probe is used for transmitting a detection light signal to the cerebral cortex or receiving a spectrum signal reflected back by the cerebral cortex;
and the lower computer is used for controlling and switching the working mode of the optical transceiving probe.
7. The system of claim 6, wherein the optical transceiver probe comprises:
at least two light emitting units for emitting probe light signals of a plurality of wavelengths;
the light receiving unit is used for receiving the spectral signals reflected back through the cerebral cortex;
a housing for enclosing the light emitting unit and the light receiving unit;
and one end of the shell is provided with an inlet and an outlet for the light signal to enter and exit.
8. The brain function imaging system with the visual and custom-arranged channels according to claim 7, wherein the two light emitting units are respectively installed on two opposite side walls of the housing in an inclined manner, two reflectors are further arranged on the two opposite side walls of the housing, the reflecting surfaces of the two reflectors respectively correspond to the light emitting directions of the two light emitting units, and the reflectors are used for guiding the detection light emitted by the light emitting units out of the inlet and outlet of the housing; the light receiving unit is installed at one end of the shell far away from the inlet and the outlet.
9. The brain function imaging system with visual and custom arrangement of channels according to claim 7, wherein the working modes of the optical transceiver probe include a transmitting mode and a receiving mode;
when the light emitting unit is switched to the emitting mode, the light receiving unit stops working, and the light emitting unit works normally;
when the receiving mode is switched, the light emitting unit stops working, and the light receiving unit works normally.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210326210.4A CN114569084A (en) | 2022-03-30 | 2022-03-30 | Brain function imaging method and system with visual and custom-arranged channels |
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| CN202210326210.4A CN114569084A (en) | 2022-03-30 | 2022-03-30 | Brain function imaging method and system with visual and custom-arranged channels |
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| CN117156072A (en) * | 2023-11-01 | 2023-12-01 | 慧创科仪(北京)科技有限公司 | Device for processing near infrared data of multiple persons, processing equipment and storage medium |
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| US20170224246A1 (en) * | 2014-08-06 | 2017-08-10 | Institute Of Automation Chinese Academy Of Sciences | Method and System for Brain Activity Detection |
| CN114176522A (en) * | 2021-12-09 | 2022-03-15 | 武汉资联虹康科技股份有限公司 | Near-infrared brain function imaging system with flexibly configurable channels |
| CN114246556A (en) * | 2022-03-01 | 2022-03-29 | 慧创科仪(北京)科技有限公司 | Positioning method, apparatus and storage medium for near-infrared brain function imaging device |
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| US20170224246A1 (en) * | 2014-08-06 | 2017-08-10 | Institute Of Automation Chinese Academy Of Sciences | Method and System for Brain Activity Detection |
| CN114176522A (en) * | 2021-12-09 | 2022-03-15 | 武汉资联虹康科技股份有限公司 | Near-infrared brain function imaging system with flexibly configurable channels |
| CN114246556A (en) * | 2022-03-01 | 2022-03-29 | 慧创科仪(北京)科技有限公司 | Positioning method, apparatus and storage medium for near-infrared brain function imaging device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117156072A (en) * | 2023-11-01 | 2023-12-01 | 慧创科仪(北京)科技有限公司 | Device for processing near infrared data of multiple persons, processing equipment and storage medium |
| CN117156072B (en) * | 2023-11-01 | 2024-02-13 | 慧创科仪(北京)科技有限公司 | Device for processing near infrared data of multiple persons, processing equipment and storage medium |
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