CN114544593A - Embedded dielectrophoresis in-situ Raman spectrum system - Google Patents
Embedded dielectrophoresis in-situ Raman spectrum system Download PDFInfo
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- CN114544593A CN114544593A CN202210227789.9A CN202210227789A CN114544593A CN 114544593 A CN114544593 A CN 114544593A CN 202210227789 A CN202210227789 A CN 202210227789A CN 114544593 A CN114544593 A CN 114544593A
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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Abstract
A built-in dielectrophoresis in-situ Raman spectrum system comprises a first laser emitter, a second laser emitter, a first lens group, a second lens group and a third lens group, wherein the first laser emitter emits first laser to the first lens group, and the first laser is converged by the first lens group and then enters a specified area of a sample container flow channel; the first laser emitted from the sample container enters the imaging camera through the objective lens; the second laser emitter emits second laser to the second lens group, the second laser is incident to a specified area of a sample container flow channel through the objective lens after the light path of the second laser is changed through the selected lens group, the second laser is reflected by the surface of liquid bubbles or liquid drops in the microemulsion controlled by dielectrophoresis in the specified area, the second laser reflected by the surface of the liquid drops of the liquid bubbles changes the light path through the selected lens group and is emitted to the third lens group, and the second laser emitted by the third lens group is captured by the Raman spectrometer. The invention can dynamically display the surface property of the liquid drop in the liquid bubble or the microemulsion in real time, and can provide a stable and controllable non-contact non-destructive in-situ characterization means for the dynamic analysis of liquid such as water or microemulsion and the like in the micro-mesoscopic scale.
Description
Technical Field
The invention belongs to the technical field of droplet forming, and particularly relates to an embedded dielectrophoresis in-situ Raman spectrum system.
Background
Since the discovery of the microemulsion system in 1943, theoretical research has been greatly developed, and the microemulsion system is widely applied to the fields of food, cosmetics, agriculture, pharmacy, medical treatment and the like. Characterization is an essential means of material research. There are many methods for characterizing the shape and physical properties of the microemulsion, such as electron microscopy, scattering technology, spectroscopy, etc., but these characterization methods all have their inherent defects and single functions.
The electron microscope technology needs to freeze and sample the microemulsion, which can damage the structure of the microemulsion and can not realize dynamic observation. The application of scattering and spectroscopy techniques has been successful, however the associated equipment is complex and the measurement process takes a long time. Temperature, as an important consideration for emulsions, plays an important role in the preparation of microemulsions and in subsequent changes. Scattering and spectroscopic techniques do not allow for in situ instantaneous characterization of the droplet morphology in a microemulsion during temperature changes. In the prior art, mechanisms are mostly speculated based on phenomena, and real-time display of droplet forms and acquisition of interface information are technical problems to be solved urgently in the development process of microemulsion technology.
Disclosure of Invention
Therefore, the invention provides an embedded dielectrophoresis in-situ Raman spectrum system, which solves the problem that the prior art cannot effectively display the liquid drop form in real time and acquire interface information.
In order to achieve the above purpose, the invention provides the following technical scheme: an in-situ Raman spectrum system with embedded dielectrophoresis comprises a first laser emitter, a first lens group, a sample container, an objective lens, an imaging camera, a second laser emitter, a second lens group, a selection lens group, a third lens group and a Raman spectrometer;
the first laser emitter emits first laser to the first lens group, and the first laser emitted by the first laser emitter is converged by the first lens group and then is incident to a specified area of the sample container flow channel; the first laser light emitted from the sample container enters the imaging camera through the objective lens;
the second laser emitter emits second laser to the second lens group, the second laser emitted by the second laser emitter is incident to the designated area of the sample container flow channel through the objective lens after the light path of the second laser is changed by the selection lens group, the surface of liquid bubbles or liquid drops in microemulsion in the designated area in the sample container flow channel reflects the second laser, the second laser reflected by the surface of the liquid drops of the liquid bubbles changes the light path through the selection lens group and emits the second laser to the third lens group, and the second laser emitted by the third lens group is incident to the Raman spectrometer.
As a preferable scheme of the in-line dielectrophoresis in-situ raman spectroscopy system, a first diaphragm is arranged between the first lens group and the sample container, and the first diaphragm is used for carrying out range and position selection on the incident area of the sample container for the first laser;
a second diaphragm is arranged between the objective lens and the sample container, and the second diaphragm selects the range and the position of second laser in an incidence area of the sample container;
the selection lens group is formed by stacking two selection lenses in the radial direction of the microscope, and the selection lens group is used for providing a new light path channel for microscope imaging to enter from the top of the sample.
The optimal scheme of the embedded dielectrophoresis in-situ Raman spectrum system also comprises a display terminal, wherein the imaging camera adopts an ultra-high speed camera with a CCD light sensing element, and the imaging camera is connected with the display terminal; the display terminal is a PC machine which can process and display image data, and is used for dynamically displaying the surface morphology of liquid bubbles or liquid drops in the microemulsion in the designated area in the flow channel of the sample container.
As a preferred scheme of the embedded dielectrophoresis in-situ Raman spectrum system, the display terminal is further connected with the Raman spectrometer, and the display terminal is used for jointly displaying the surface morphology of the liquid drops, Raman spectrum signals and indexes obtained by processing.
As a preferable scheme of the in-line dielectrophoresis in-situ Raman spectroscopy system, the sample container is integrated with a fluid channel, two sides of the fluid channel are deposited with dielectrophoresis electrodes, the dielectrophoresis electrodes are connected with a signal generator, and the dielectrophoresis electrodes are used for controlling the space position of bubbles in liquid or liquid drops in microemulsion in a designated area.
As a preferred scheme of the in-situ Raman spectrum system of the in-line dielectrophoresis, the sampleA base platform is arranged below the container, and the sample container is made of ITO, SiC, IZO or Al2O3And an organic compound.
As a preferable scheme of the embedded dielectrophoresis in-situ Raman spectrum system, the dielectrophoresis electrode is made of at least one of Au, Ag, Sb, Sn, Pt, Cu, Al or semiconductor IZO and ITO.
As a preferable scheme of the embedded dielectrophoresis in-situ Raman spectroscopy system, the first diaphragm and the second diaphragm are made of at least one of Cu, Al, Mo and Pt.
As a preferred scheme of the in-situ raman spectroscopy system with embedded dielectrophoresis, the first laser emitted by the first laser emitter is any one of red light, blue light and green light;
the second laser transmitter emits second laser wavelength of 785nm/1300 nm.
As a preferable scheme of the in-line dielectrophoresis in-situ raman spectroscopy system, the wavelength of the first laser emitted by the first laser emitter is green light 525 nm;
the wavelength of the second laser emitted by the second laser emitter is 785 nm.
The invention has the following advantages: the device is provided with a first laser emitter, a first lens group, a sample container, an objective lens, an imaging camera, a second laser emitter, a second lens group, a selection lens group, a third lens group and a Raman spectrometer; the first laser emitter emits first laser to the first lens group, and the first laser emitted by the first laser emitter is converged by the first lens group and then enters a designated area of the sample container flow channel; the first laser emitted from the sample container enters the imaging camera through the objective lens; the second laser transmitter transmits second laser to the second lens group, the second laser transmitted by the second laser transmitter is transmitted to the designated area of the sample container flow channel through the objective lens after the light path is changed by the selection lens group, the liquid bubbles or the liquid drop surface in the microemulsion in the designated area in the sample container flow channel reflects the second laser, the second laser reflected by the liquid drop surface of the liquid bubbles changes the light path through the selection lens group and is transmitted to the third lens group, and the second laser transmitted by the third lens group is transmitted to the Raman spectrometer. The method can dynamically show the surface properties of liquid bubbles or liquid drops in the microemulsion in real time, and can provide a stable and controllable non-contact non-destructive in-situ characterization means for dynamic analysis of liquid such as water or microemulsion on the micro-mesoscopic scale.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so that those skilled in the art can understand and read the present invention, and do not limit the conditions for implementing the present invention, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the functions and purposes of the present invention, should still fall within the scope of the present invention.
FIG. 1 is a schematic diagram of an in-line dielectrophoresis in-situ Raman spectroscopy system provided in an embodiment of the invention;
fig. 2 is a modification example of the in-line dielectrophoresis in-situ raman spectroscopy system provided in the embodiment of the present invention.
In the figure, 1, a first laser transmitter; 2. a first lens group; 3. a sample container; 4. an objective lens; 5. an imaging camera; 6. a second laser transmitter; 7. a second lens group; 8. selecting a lens group; 9. a third lens group; 10. a Raman spectrometer; 11. a first diaphragm; 12. a second diaphragm; 13. a display terminal; 14. a fluid channel; 15. dielectrophoresis electrodes; 16. a base station.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 and fig. 2, an in-line dielectrophoresis in-situ raman spectroscopy system according to an embodiment of the present invention includes a first laser emitter 1, a first lens group 2, a sample container 3, an objective lens 4, an imaging camera 5, a second laser emitter 6, a second lens group 7, a selection lens group 8, a third lens group 9, and a raman spectrometer 10;
the first laser emitter 1 emits first laser to the first lens group 2, and the first laser emitted by the first laser emitter 1 is converged by the first lens group 2 and then is incident to a specified area of a flow channel of the sample container 3; the first laser light emitted from the sample container 3 enters the imaging camera 5 through the objective lens 4;
the second laser emitter 6 emits second laser to the second lens group 7, the second laser emitted by the second laser emitter 6 is incident to a designated area of the flow channel of the sample container 3 through the objective lens 4 after the light path of the second laser is changed by the selection lens group 8, the surface of liquid bubbles or liquid drops in microemulsion in the designated area in the flow channel of the sample container 3 reflects the second laser, the second laser reflected by the surface of the liquid drops of the liquid bubbles changes the light path through the selection lens group 8 and emits the second laser to the third lens group 9, and the second laser emitted by the third lens group 9 is incident to the raman spectrometer 10.
In this embodiment, the first lens group 2 includes a plurality of biconvexs, the second lens group 7 includes two biconvexs and a reflector, and the emission directions of the first laser and the second laser are perpendicular. The selection lens group 8 is formed by stacking two selection lenses in the radial direction of the microscope, and can provide a new light path channel for microscope imaging so that the light path channel can enter from the top of a sample.
In the embodiment, a first diaphragm 11 is arranged between the first lens group 2 and the sample container 3, and the first diaphragm 11 selects the range and the position of the first laser in the incidence area of the sample container 3; a second diaphragm 12 is arranged between the objective 4 and the sample container 3, and the second diaphragm 12 selects the range and the position of the second laser light in the incident region of the sample container 3. The material of the first aperture 11 and the second aperture 12 includes, but is not limited to, materials with low light transmittance such as Cu, Al, Mo, Pt, and the like. The first laser emitted by the first laser emitter 1 is any one of red light, blue light and green light; the second laser light emitted by the second laser emitter 6 has any one of 785nm/1300nm wavelengths. The wavelength of the first laser emitted by the first laser emitter 1 is green light, and is preferably 525 nm; the second laser light emitted by the second laser transmitter 6 preferably has a wavelength of 785 nm.
Specifically, the first diaphragm 11 enables the area of the sample container 3 into which the first laser beam is incident to be selected, the light path passing through the first diaphragm 11 passes through the objective lens 4 to enter the imaging camera 5, and the operating area can be directionally selected by means of the imaging camera 5. The second diaphragm 12 is tightly attached to the upper part of the sample container 3, the second diaphragm 12 is convenient for the positioning of the spectroscopic system, the second laser is reflected by bubbles in the liquid in the designated area, namely the surface of gas and liquid or the surface of small liquid drops in microemulsion, and then the light path is changed by the selection lens group 8, emitted to the third lens group 9 and then emitted to the Raman spectrometer 10.
In the embodiment, the system further comprises a display terminal 13, the imaging camera 5 adopts an ultra-high speed camera with a CCD light sensing element, and the imaging camera 5 is connected with the display terminal 13; the display terminal 13 is a PC capable of processing and displaying image data, and the display terminal 13 is used for dynamically displaying the surface morphology of the liquid bubbles or droplets in the microemulsion in a designated area in the flow channel of the sample container 3. The display terminal 13 is further connected with the raman spectrometer 10, and the display terminal 13 performs combined display on the surface morphology of the liquid drop, the raman spectrum signal and the processed index. The sample container 3 is integrated with a fluid channel 14, two sides of the fluid channel 14 are deposited with dielectrophoresis electrodes 15, the dielectrophoresis electrodes 15 are made of at least one of Au, Ag, Sb, Sn, Pt, Cu, Al or semiconductor IZO and ITO, the dielectrophoresis electrodes 15 are connected with a signal generator, and the dielectrophoresis electrodes 15 are used for controlling the space position of bubbles in liquid or liquid drops in microemulsion in a designated area.
Specifically, the imaging camera 5 and the raman spectrometer 10 belong to the prior art, and the imaging camera 5 and the raman spectrometer 10 are connected with the display terminal 13 with a display, so that the operating area of the sample container 3 can be directionally selected. The fluid channel 14 allows liquid to flow, the dielectrophoresis electrode 15 can control bubbles in the liquid or small droplets in the microemulsion in the area to move, the bubbles in the liquid or the small droplets in the microemulsion in the area to be controlled can also be fixed, the observation is convenient, the property of the object to be detected can be dynamically displayed in real time by virtue of the display terminal 13, and an effective in-situ characterization means is provided for the dynamic analysis of the microemulsion on the micro-mesoscopic scale.
In this embodiment, the base 16 is disposed below the sample container 3, and the material for manufacturing the sample container 3 includes, but is not limited to, high-transmittance materials such as ITO, SiC, IZO, Al2O3, and SiO 2. That is, the sample container 3 and the base 16 are both made of transparent materials, so that the sample container 3 can be observed conveniently from a macroscopic angle, and meanwhile, the base 16 can support without influencing the passing of laser.
In summary, the invention is provided with a first laser emitter 1, a first lens group 2, a sample container 3, an objective lens 4, an imaging camera 5, a second laser emitter 6, a second lens group 7, a selection lens group 8, a third lens group 9 and a raman spectrometer 10; the first laser emitter 1 emits first laser to the first lens group 2, and the first laser emitted by the first laser emitter 1 is converged by the first lens group 2 and then is incident to a specified area of a flow channel of the sample container 3; the first laser light emitted from the sample container 3 enters the imaging camera 5 through the objective lens 4; the second laser emitter 6 emits second laser to the second lens group 7, the second laser emitted by the second laser emitter 6 is incident to a designated area of the flow channel of the sample container 3 through the objective lens 4 after the light path of the second laser is changed by the selection lens group 8, the surface of liquid bubbles or liquid drops in microemulsion in the designated area in the flow channel of the sample container 3 reflects the second laser, the second laser reflected by the surface of the liquid drops of the liquid bubbles changes the light path through the selection lens group 8 and emits the second laser to the third lens group 9, and the second laser emitted by the third lens group 9 is incident to the raman spectrometer 10. The sample container 3 is integrated with a fluid channel 14, a dielectrophoresis electrode 15 arranged according to a specific function is integrated in the vicinity of the fluid channel 14, the dielectrophoresis electrode 15 is connected with a signal generator, and the dielectrophoresis electrode 15 is used for controlling the space position of bubbles in a liquid or droplets in a microemulsion in a designated area. The first diaphragm 11 enables the selection of the region of the sample container 3 into which the first laser light is incident, the light path passing through the first diaphragm 11 passing through the objective 4 into the imaging camera 5, the operating region being directionally selectable by means of the imaging camera 5. The second diaphragm 12 is tightly attached to the upper part of the sample container 3, the second diaphragm 12 is convenient for the positioning of the spectroscopic system, the second laser is reflected by bubbles in the liquid in the designated area, namely the surface of gas and liquid or the surface of small liquid drops in microemulsion, and then the light path is changed by the selection lens group 8, emitted to the third lens group 9 and then emitted to the Raman spectrometer 10. The fluid channel 14 allows liquid to flow, the dielectrophoresis electrode 15 can control bubbles in the liquid or small droplets in the microemulsion in the area to move, the bubbles in the liquid or the small droplets in the microemulsion in the control area can also be fixed, the observation is convenient, the property of an object to be detected can be dynamically displayed in real time by virtue of the display terminal 13, and an effective in-situ characterization means is provided for the dynamic analysis of the microemulsion in the micro-mesoscale.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. An in-situ Raman spectroscopy system with embedded dielectrophoresis is characterized by comprising a first laser emitter (1), a first lens group (2), a sample container (3), an objective lens (4), an imaging camera (5), a second laser emitter (6), a second lens group (7), a selection lens group (8), a third lens group (9) and a Raman spectrometer (10);
the first laser emitter (1) emits first laser to the first lens group (2), and the first laser emitted by the first laser emitter (1) is converged by the first lens group (2) and then enters a designated area of a flow channel of the sample container (3); the first laser light emitted from the sample container (3) enters the imaging camera (5) through the objective lens (4);
the second laser emitter (6) emits second laser to the second lens group (7), the second laser emitted by the second laser emitter (6) is incident to a designated area of a flow channel of the sample container (3) through the objective lens (4) after a light path of the second laser is changed through the selection lens group (8), the second laser is reflected by the surface of liquid bubbles or liquid drops in microemulsion in the designated area in the flow channel of the sample container (3), the light path of the second laser reflected by the surface of the liquid drops of the liquid bubbles is changed through the selection lens group (8) and is emitted to the third lens group (9), and the second laser emitted by the third lens group (9) is incident to the Raman spectrometer (10).
2. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 1, wherein a first diaphragm (11) is arranged between the first lens group (2) and the sample container (3), the first diaphragm (11) providing range and position selection for the incidence area of the first laser light on the sample container (3);
a second diaphragm (12) is arranged between the objective lens (4) and the sample container (3), and the second diaphragm (12) selects the range and the position of the second laser in the incidence area of the sample container (3);
the selection lens group (8) is formed by stacking two selection lenses in the radial direction of the microscope, and the selection lens group (8) is used for providing a new optical path channel for microscope imaging to enter from the top of the sample.
3. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 2, further comprising a display terminal (13), wherein the imaging camera (5) is an ultra-high speed camera employing CCD photo-sensing elements, and the imaging camera (5) is connected to the display terminal (13); the display terminal (13) is a PC for processing and displaying image data; the display terminal (13) is used for dynamically displaying the surface morphology of liquid bubbles or liquid drops in the micro-emulsion in a designated area in the flow channel of the sample container (3).
4. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 3, wherein the display terminal (13) is further connected to the Raman spectrometer (10), and the display terminal (13) displays the surface morphology of the liquid drop, the Raman spectrum signal and the processed index in combination.
5. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 3, wherein the sample vessel (3) is integrated with a fluid channel (14), dielectrophoresis electrodes (15) are deposited on both sides of the fluid channel (14), the dielectrophoresis electrodes (15) are connected to a signal generator, and the dielectrophoresis electrodes (15) are used for spatial position control of bubbles in the liquid or droplets in the microemulsion in a specified region.
6. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 5, wherein a base (16) is arranged below the sample container (3), and the sample container (3) is made of ITO, SiC, IZO or Al2O3And an organic compound.
7. The in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 6, wherein the dielectrophoresis electrode (15) is made of at least one of Au, Ag, Sb, Sn, Pt, Cu, Al, or IZO, ITO.
8. An in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 2, wherein the first diaphragm (11) and the second diaphragm (12) are made of at least one of Cu, Al, Mo and Pt.
9. The in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 1, wherein the first laser light emitted by the first laser emitter (1) is any one of red light, blue light and green light;
the second laser transmitter (6) emits second laser wavelength of 785nm/1300 nm.
10. The in-line dielectrophoresis in-situ Raman spectroscopy system according to claim 9, wherein the first laser emitter (1) emits first laser light having a wavelength of 525 nm; the wavelength of the second laser emitted by the second laser emitter (6) is 785 nm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210227789.9A CN114544593A (en) | 2022-03-08 | 2022-03-08 | Embedded dielectrophoresis in-situ Raman spectrum system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210227789.9A CN114544593A (en) | 2022-03-08 | 2022-03-08 | Embedded dielectrophoresis in-situ Raman spectrum system |
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