CN114533037B - Disease detection system and method based on children breathing gas - Google Patents
Disease detection system and method based on children breathing gas Download PDFInfo
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- CN114533037B CN114533037B CN202210167494.7A CN202210167494A CN114533037B CN 114533037 B CN114533037 B CN 114533037B CN 202210167494 A CN202210167494 A CN 202210167494A CN 114533037 B CN114533037 B CN 114533037B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
Abstract
The invention discloses a disease detection system and method based on child breathing gas, and relates to the technical field of expiration detection. The system comprises a server and expiration acquisition detection equipment (hereinafter referred to as equipment), wherein the equipment measures the temperature and the humidity of expired gas and gas to be acquired and respectively sends the temperature and the humidity as a first gas parameter and a second gas parameter to the server; so that the server generates a first control instruction and a second control instruction; the equipment adjusts the temperature of the equipment according to the first control instruction to obtain the gas to be collected, and the equipment adjusts the temperature of the equipment according to the second control instruction to collect the sample to be detected in the gas to be collected; detecting the content of various target compounds in a sample to be detected, and sending the content to a server as a detection result; the server alerts about the content of each target compound. Through the temperature of adjusting equipment, reduce the content of vapor in the expired gas, and then improve the efficiency that expired gas gathered, shorten acquisition time, guarantee the accuracy of testing result.
Description
Technical Field
The invention relates to the technical field of expiration detection, in particular to a disease detection system and method based on children breathing gas.
Background
Exhaled breath analysis has become a common diagnostic method for non-invasive health diagnosis. Some organic compounds in the exhaled air of the human body can become biomarkers of various diseases, and whether the human body has the diseases or not can be judged by collecting and detecting the exhaled air and analyzing the content of the biomarkers. In the prior art, detection is usually performed by two exhaled gas samples according to the volatilization properties of the biomarkers: collecting and detecting exhaled breath for detecting Volatile Organic Compounds (VOCs) in the exhaled breath; respiratory gas condensate (EBC) is collected and detected for detection of non-volatile organic compounds in exhaled breath.
In actual breath testing, the biomarker levels are typically on the ppm (parts per million concentration) scale due to the very low levels in respiratory gases. Therefore, a long gas sample collection is required to effectively analyze the levels of biomarkers in the respiratory gases. And to children expiration detection, need shorten the time that gaseous sample gathered as far as to avoid because too long time gaseous sample gathers and probably influences children's mood, and then leads to the maloperation, influences the testing result accuracy.
Disclosure of Invention
The present invention is directed to solving the above-mentioned problems of the background art, and provides a disease detection system and method based on children breathing gas.
The purpose of the invention can be realized by the following technical scheme:
in a first aspect of the embodiments of the present invention, there is provided a disease detection system based on children breathing gas, including a server and an expired air collection and detection device, wherein:
the breath collecting and detecting device is used for measuring the temperature and the humidity of the exhaled gas of the person to be detected according to a preset period, and sending the temperature and the humidity as first gas parameters to the server;
the server is used for sending a first control instruction to the breath collecting and detecting equipment according to the first gas parameter;
the breath collecting and detecting device is further used for adjusting the temperature of the breath collecting and detecting device according to the first control instruction so as to reduce the content of water vapor in the exhaled air and obtain a gas to be collected; measuring the temperature and humidity of the gas to be collected according to a preset period, and sending the temperature and humidity as second gas parameters to the server;
the server is used for sending a second control instruction to the breath collecting and detecting equipment according to the second gas parameter;
the breath collecting and detecting device is further used for adjusting the temperature of the breath collecting and detecting device according to the second control instruction so as to collect the compound in the gas to be collected as a sample to be detected; detecting the content of a plurality of target compounds in the sample to be detected, and sending the content to the server as a detection result;
the server is further configured to alarm for each target compound if the content of the target compound in the detection result is not within a preset range.
In a second aspect of the embodiments of the present invention, there is also provided a disease detection method based on child breathing gas, where the method is applied to an expired air collection and detection device, and includes:
measuring the temperature and humidity of the exhaled air of the person to be detected according to a preset period, and sending the temperature and humidity as first air parameters to the server; so that the server sends a first control instruction to the breath collection and detection device according to the first gas parameter;
adjusting the temperature of the breath collection detection equipment according to the first control instruction so as to reduce the content of water vapor in the exhaled breath to serve as gas to be collected;
measuring the temperature and the humidity of the gas to be collected according to a preset period, and sending the temperature and the humidity as second gas parameters to the server; so that the server sends a second control instruction to the breath collection and detection device according to the second gas parameter;
adjusting the temperature of the breath collecting and detecting equipment according to the second control instruction so as to collect the compound in the gas to be collected as a sample to be detected;
detecting the content of a plurality of target compounds in the sample to be detected, and sending the content to the server as a detection result; and aiming at each target compound, if the content of the target compound in the detection result is not in a preset range, the server gives an alarm.
Optionally, the breath collection detection device comprises a gas input module and a saliva collection module;
before measuring the temperature and humidity of the exhaled air of the person to be detected and sending the temperature and humidity to the server as air parameters, the method further comprises the following steps:
collecting the exhaled mixture of the person to be detected through the gas input module;
and removing saliva drops in the exhaled mixture through a saliva collecting module to obtain the exhaled air.
Optionally, the breath collecting and detecting device further comprises a condenser tube module, a first sensor module, a second sensor module and a first cooling module; the condenser pipe module comprises an unsaturated section and a supersaturated section, and when breath collection detection is carried out, the expired gas firstly passes through the unsaturated section to obtain the gas to be collected, and then the gas to be collected passes through the supersaturated section; the first sensor module is disposed at an input end of the unsaturated segment; the second sensor module is disposed at an intersection of an output end of the undersaturation section and an input end of the oversaturation section; the first cooling module is disposed at the unsaturated section;
the temperature and the humidity of the exhaled air of a person to be detected are measured according to a preset period and are sent to the server as first air parameters, and the method comprises the following steps:
acquiring, by the first sensor module, a first temperature and a first humidity of the exhaled gas;
collecting, by the second sensor module, a second temperature and a second humidity of the exhaled gas;
sending the first temperature, the first humidity, the second temperature and the second humidity as first gas parameters to the server according to a preset period;
adjusting the temperature of the breath collection detection device according to the first control instruction to reduce the content of water vapor in the exhaled breath as a gas to be collected, comprising:
and starting the first cooling module according to the first control instruction so as to enable the exhaled air to be in an unsaturated state, and forming a condensation film on the inner wall of the unsaturated section so as to reduce the content of water vapor in the exhaled air to be used as the gas to be collected.
Optionally, the exhaled breath collection and detection apparatus further comprises a third sensor module, a second cooling module, an exhaled breath condensate EBC collection module, and a volatile organic compound VOC collection module; the third sensor module and the VOC acquisition module are deployed at the output end of the supersaturated section; the second cooling module is deployed in the supersaturated section; the EBC acquisition module is deployed at the intersection of the output end of the unsaturated section and the input end of the supersaturated section;
measuring the temperature and the humidity of the gas to be collected according to a preset period, and sending the temperature and the humidity to the server as second gas parameters, wherein the method comprises the following steps:
collecting, by the second sensor module, a third temperature and a third humidity of the gas to be collected;
acquiring a fourth temperature and a fourth humidity of the gas to be acquired through the third sensor module;
sending the third temperature, the third humidity, the fourth temperature and the fourth humidity as second gas parameters to the server according to a preset period;
adjusting the temperature of the breath collection and detection device according to the second control instruction to collect the compound in the gas to be collected as a sample to be detected, including:
starting the second cooling module according to the second control instruction so that the gas to be collected is in a supersaturated state, and forming condensate containing non-volatile compounds on the inner wall of the supersaturated section;
collecting the condensate through the EBC collection module to serve as EBC to be detected;
and collecting the gas to be collected containing volatile compounds through the VOC collecting module to serve as the VOC to be detected.
Optionally, the detection result includes the content of the plurality of non-volatile compounds in the EBC to be detected and the content of the plurality of volatile compounds in the VOC to be detected.
In a third aspect of the embodiments of the present invention, there is also provided a disease detection method based on children breathing gas, where the method is applied to a server, and includes:
receiving a first gas parameter acquired by breath acquisition and detection equipment, and sending a first control instruction to the breath acquisition and detection equipment according to the first gas parameter; the first gas parameter is the temperature and humidity of the exhaled gas of the person to be detected; adjusting the temperature of the breath collection and detection equipment by the breath collection and detection equipment according to the first control instruction to reduce the content of water vapor in the exhaled air, taking the breath collection and detection equipment as a gas to be collected, measuring the temperature and humidity of the gas to be collected, and sending the measured temperature and humidity as second gas parameters to the server;
receiving the second gas parameter, and sending a second control instruction to the breath collection detection equipment according to the second gas parameter; adjusting the temperature of the breath collection detection equipment according to the second control instruction by the breath collection detection equipment to collect compounds in the gas to be collected as a sample to be detected, detecting the content of various target compounds in the sample to be detected, and sending the content as a detection result to the server;
and receiving the detection result, and alarming for each target compound if the content of the target compound in the detection result is not in a preset range.
Optionally, the first gas parameter comprises a first temperature, a first humidity, a second temperature, and a second humidity of the exhaled gas; the first temperature and the first humidity are acquired by a first sensor module of the breath acquisition detection device; the second temperature and the second humidity are acquired by a second sensor module of the breath acquisition and detection device; the first sensor module and the second sensor module are deployed at a condenser tube module of the breath collection testing device; the condensation pipe module comprises an unsaturated section and a supersaturated section, and when expiration collection detection is carried out, the expired gas firstly passes through the unsaturated section to obtain the gas to be collected, and then the gas to be collected passes through the supersaturated section; the first sensor module is deployed at an input end of the unsaturated section; the second sensor module is disposed at an intersection of an output end of the undersaturation section and an input end of the oversaturation section;
receiving a first gas parameter collected by breath collection detection equipment, and sending a first control instruction to the breath collection detection equipment according to the first gas parameter, wherein the breath collection detection equipment comprises:
calculating a saturation ratio of the exhaled gas as a first saturation ratio based on the first temperature and the first humidity; the saturation ratio is used for judging whether the exhaled air is in a saturated state;
calculating a saturation ratio of the exhaled air as a second saturation ratio based on the second temperature and the second humidity;
and sending a first control instruction to the breath collection detection device, so that the first saturation ratio is smaller than 1, and the second saturation ratio is equal to 1.
Optionally, the second gas parameter includes a third temperature, a third humidity, a fourth temperature, and a fourth humidity of the gas to be collected; the third temperature and the third humidity are collected by the second sensor module; the fourth temperature and the fourth humidity are acquired by a third sensor module of the breath acquisition and detection device; the third sensor module is deployed at an output of the oversaturation section;
receiving the second gas parameter, and sending a second control instruction to the breath collection detection device according to the second gas parameter, including:
calculating the saturation ratio of the gas to be collected according to the third temperature and the third humidity, and taking the saturation ratio as a third saturation ratio;
calculating the saturation ratio of the gas to be collected according to the fourth temperature and the fourth humidity to serve as a fourth saturation ratio;
and sending a second control instruction to the breath collection detection device to enable the third saturation ratio to be equal to 1 and the fourth saturation ratio to be larger than 1.
Optionally, the sample to be detected comprises an EBC to be detected and a VOC to be detected, and the detection result comprises the content of multiple non-volatile compounds in the EBC to be detected and the content of multiple volatile compounds in the VOC to be detected.
The disease detection system based on the children breathing gas comprises a server and expiration collecting and detecting equipment, wherein the expiration collecting and detecting equipment measures the temperature and the humidity of the expired gas of a person to be detected according to a preset period and sends the temperature and the humidity as first gas parameters to the server; the server sends a first control instruction to the breath collecting and detecting equipment according to the first gas parameters; the breath collecting and detecting device adjusts the temperature of the breath collecting and detecting device according to the first control instruction so as to reduce the content of water vapor in the exhaled air to obtain the gas to be collected, measures the temperature and the humidity of the gas to be collected according to a preset period, and sends the temperature and the humidity as second gas parameters to the server; the server sends a second control instruction to the breath collecting and detecting equipment according to the second gas parameter; the breath collection detection device adjusts the temperature of the breath collection detection device according to the second control instruction so as to collect the compound in the gas to be collected as a sample to be detected; detecting the content of various target compounds in a sample to be detected, and sending the content to a server as a detection result; and the server gives an alarm for each target compound if the content of the target compound in the detection result is not in a preset range. The temperature of the exhaled air collection detection equipment is adjusted, the content of water vapor in the exhaled air is reduced, the exhaled air collection efficiency is improved, the collection time is shortened, and the accuracy of detection results is guaranteed.
Drawings
The invention will be further described with reference to the accompanying drawings.
FIG. 1 is a block diagram of a childhood respiratory gas-based disease detection system according to an embodiment of the present invention;
FIG. 2 is a flow chart of a method for detecting a disease based on respiratory gases of children according to an embodiment of the present invention;
fig. 3 is a flowchart of a disease detection method based on children breathing gas according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides a disease detection system based on children breathing gas. Referring to fig. 1, fig. 1 is a block diagram of a disease detection system based on children breathing gas according to an embodiment of the present invention. The system comprises a server 101 and an breath acquisition detection device 102, wherein:
the breath collecting and detecting device 102 is used for measuring the temperature and humidity of the exhaled breath of the person to be detected according to a preset period, and sending the temperature and humidity as first gas parameters to the server 101;
the server 101 is used for sending a first control instruction to the exhaled breath collecting and detecting device 102 according to the first gas parameter;
the breath collecting and detecting device 102 is further configured to adjust the temperature of the breath collecting and detecting device 102 according to the first control instruction, so as to reduce the content of water vapor in the exhaled air, and obtain a gas to be collected; measuring the temperature and humidity of the gas to be collected according to a preset period, and sending the temperature and humidity as second gas parameters to the server 101;
the server 101 is configured to send a second control instruction to the breath collecting and detecting device 102 according to the second gas parameter;
the breath collecting and detecting device 102 is further configured to adjust the temperature of the breath collecting and detecting device 102 according to the second control instruction, so as to collect a compound in the gas to be collected, which is used as a sample to be detected; detecting the content of various target compounds in a sample to be detected, and sending the content as a detection result to the server 101;
the server 101 is further configured to alarm, for each target compound, if the content of the target compound in the detection result is not within a preset range.
According to the expiration detection system for children medical treatment provided by the embodiment of the invention, the content of water vapor in expired gas is reduced by adjusting the temperature of expiration collection detection equipment, so that the expired gas collection efficiency is improved, the collection time is shortened, and the accuracy of a detection result is ensured.
In one implementation, the server 101 may include a first receiving module 1011, a first sending module 1012, an instruction generating module 1013, and a detection result determining module 1014.
The receiving module 1011 is configured to receive the first gas parameter, the second gas parameter, and the detection result sent by the breath collection and detection device 102. A sending module 1012, configured to send the first control instruction and the second control instruction to the breath collection and detection device 102. The instruction generating module 1013 is configured to generate a first control instruction according to the first gas parameter and generate a second control instruction according to the second gas parameter. The detection result determining module 1014 is configured to, for each target compound, alarm if the content of the target compound in the detection result is not within a preset range.
Breath collection detection device 102 may include a gas input module 1021, a saliva collection module 1022, a condenser tube module 1023, a first sensor module 1024, a second sensor module 1025, a third sensor module 1026, a first cooling module 1027, a second cooling module 1028, an exhaled breath condensate EBC collection module 1029, a volatile organic compound VOC collection module 10210, a second transmission module 10211, a second reception module 10212, and a detection module 10213.
And a gas input module 1021 for collecting the exhaled mixture of the person to be detected. And a saliva collecting module 1022, configured to remove saliva droplets from the exhaled mixture to obtain exhaled air.
And the condensing tube module 1023 is used for reducing the content of water vapor in the exhaled gas to obtain the gas to be collected, and then condensing the gas to be collected into liquid. The condenser tube module 1023 comprises an unsaturated section and a supersaturated section, and when expiration collection detection is carried out, expired gas firstly passes through the unsaturated section to obtain gas to be collected, and then the gas to be collected passes through the supersaturated section; the first sensor module 1024 is disposed at the input end of the unsaturated section and is used for detecting the temperature and humidity of the exhaled gas entering the input end of the unsaturated section; the second sensor module 1025 is deployed at the intersection of the output end of the unsaturated section and the input end of the supersaturated section, exhaled gas at the intersection is to-be-collected gas, and the second sensor module 1025 is used for detecting the temperature and humidity of the exhaled gas flowing out of the output end of the unsaturated section, namely the temperature and humidity of the to-be-collected gas entering the input end of the supersaturated section; a third sensor module 1026 is deployed at the output of the supersaturated section for detecting the temperature and humidity of the gas to be collected as it exits the output of the supersaturated section.
A first cooling module 1027 disposed at the unsaturated zone for adjusting a temperature of the unsaturated zone according to a first control command; a second cooling module 1028 is disposed in the supersaturated section for adjusting the temperature of the supersaturated section according to a second control command; the exhaled gas condensate EBC acquisition module 1029 is arranged at the intersection of the output end of the unsaturated section and the input end of the supersaturated section, and is used for acquiring condensate formed by the supersaturated section as the EBC to be detected; a VOC collection module 10210 is disposed at the output end of the supersaturated section for collecting the gas to be collected containing volatile compounds as the VOC to be detected. The detection module 10213 is used for detecting the contents of various target compounds in the EBC to be detected and the VOC to be detected as detection results.
A second sending module 10211, configured to send the first gas parameter, the second gas parameter, and the detection result to the server 101; the second receiving module 10212 is configured to receive the first control instruction and the second control instruction sent by the server 101.
The embodiment of the invention also provides a disease detection method based on children breathing gas, which is applied to the breath collection and detection device 102. Referring to fig. 2, fig. 2 is a flowchart of a disease detection method based on children breathing gas according to an embodiment of the present invention. The method may comprise the steps of:
s201: the temperature and the humidity of the exhaled air of the person to be detected are measured according to a preset period and are sent to the server as first air parameters, so that the server sends a first control instruction to the exhaled air collecting and detecting device according to the first air parameters.
S202: and adjusting the temperature of the exhaled air collecting and detecting equipment according to the first control instruction so as to reduce the content of water vapor in the exhaled air and obtain the gas to be collected.
S203: and measuring the temperature and the humidity of the gas to be collected according to a preset period, and sending the temperature and the humidity as second gas parameters to the server so that the server sends a second control instruction to the breath collection detection equipment according to the second gas parameters.
S204: and adjusting the temperature of the breath collecting and detecting equipment according to the second control instruction so as to collect the compound in the gas to be collected as the sample to be detected.
S205: and detecting the content of various target compounds in the sample to be detected, and sending the content as a detection result to the server so that the server can give an alarm for each target compound if the content of the target compound in the detection result is not within a preset range.
According to the expired air detection method for children medical treatment provided by the embodiment of the invention, the temperature of expired air collection detection equipment is adjusted, so that the content of water vapor in expired air is reduced, the expired air collection efficiency is improved, the collection time is shortened, and the accuracy of a detection result is ensured.
In one implementation, the preset period may be set by a technician according to experience, and is not limited herein. The first gas parameter and the second gas parameter are sent through periodic collection, the temperature of the breath collection detection equipment can be adjusted in real time in the whole breath collection process, the content of water vapor in the exhaled gas is reduced, and compounds in the gas to be collected are collected.
In one implementation, the exhaled breath is a mixture, assuming a composition of 75% nitrogen, 15.1% oxygen, 3.7% carbon dioxide, 6.2% water vapor, and ppm (parts per million concentration) level biomarker compounds (the target compounds described above).
In one implementation, the compound of interest may be a compound used in the art to diagnose childhood disease. For example, the target compound may be isoprene, acetone, isopropanol, 1-propanol, 2-butanone, 2-pentanone, toluene, xylene, cortisol, and 8-isoprostaglandin F 2α And the like.
In one embodiment, an breath collection detection device includes a gas input module and a saliva collection module;
before step S201, the method further includes:
step one, collecting the exhaled mixture of the person to be detected through a gas input module.
And step two, removing saliva drops in the exhaled mixture through a saliva collecting module to obtain exhaled air.
In one implementation, the gas input module may be a disposable plastic mouthpiece that facilitates collection of the child's exhale mix.
In one embodiment, step S201 includes:
step one, collecting a first temperature and a first humidity of exhaled air through a first sensor module.
And step two, acquiring a second temperature and a second humidity of the exhaled air through a second sensor module.
And step three, sending the first temperature, the first humidity, the second temperature and the second humidity as first gas parameters to a server according to a preset period, so that the server sends a first control instruction to the breath collecting and detecting equipment according to the first gas parameters.
Step S202 specifically includes:
and starting the first cooling module according to the first control instruction so as to enable the exhaled air to be in an unsaturated state, and forming a condensation film on the inner wall of the unsaturated section so as to reduce the content of water vapor in the exhaled air to be used as the gas to be collected.
In one implementation, the server may calculate a saturation ratio of the exhaled gas as a first saturation ratio based on the first temperature and the first humidity, and calculate a saturation ratio of the exhaled gas as a second saturation ratio based on the second temperature and the second humidity.
According to the Antoine equation, namely the formula (1), the saturated vapor pressure P of the water vapor can be calculated sat 。
Wherein, C1, C2 and C3 are Antoine constants respectively, and T is the temperature of the mixed gas (which may be the exhaled gas, or may be the gas to be collected).
The partial vapor pressure can be calculated using equation (2):
P v ＝cRT (2)
wherein R is the universal gas constant of water vapor, and c is the concentration of water vapor in the mixed gas, namely the humidity of the mixed gas.
The saturation ratio of the vapor can be calculated using equation (3):
in the condensation module, if the mixed gas delta is less than 1, the mixed gas is unsaturated, and if the delta is more than 1, the mixed gas is supersaturated. When the mixed gas is in an unsaturated state, the overall temperature of the mixed gas is higher than the dew point temperature of the water vapor, and the water vapor can form a thin condensation film by diffusing to the supercooling wall. When the mixed gas is in a supersaturated state, the overall temperature of the mixed gas is lower than the dew point temperature of water vapor, and the water vapor diffuses to the supercooling wall to form liquid drops.
The server sends a first control instruction to the expiration collection detection device, so that the first saturation ratio is smaller than 1, the second saturation ratio is equal to 1, and the mixed gas is in an unsaturated state in an unsaturated section. And then to
In one embodiment, step S203 comprises:
step one, collecting a third temperature and a third humidity of the exhaled air through a second sensor module.
And step two, acquiring a fourth temperature and a fourth humidity of the gas to be acquired through a third sensor module.
And step three, sending the third temperature, the third humidity, the fourth temperature and the fourth humidity serving as second gas parameters to the server according to a preset period, so that the server sends a second control instruction to the breath collecting and detecting device according to the second gas parameters.
Step S204 includes:
step one, a second cooling module is started according to a second control instruction so that the gas to be collected is in a supersaturated state, and condensate containing a non-volatile compound is formed on the inner wall of a supersaturated section;
collecting condensate through an EBC collection module to serve as EBC to be detected;
and step three, collecting the gas to be collected containing the volatile compounds through a VOC collecting module to serve as the VOC to be detected.
In one implementation, the server may calculate a saturation ratio of the gas to be collected according to the third temperature and the third humidity as a third saturation ratio, and calculate a saturation ratio of the gas to be collected according to the fourth temperature and the fourth humidity as a fourth saturation ratio.
The server sends a second control instruction to the expiration collection detection equipment, so that the third saturation ratio can be equal to 1, the fourth saturation ratio is greater than 1, and the mixed gas is in a supersaturated state in the supersaturated section.
In one embodiment, the assay results include the levels of the plurality of non-volatile compounds in the EBC to be assayed and the levels of the plurality of volatile compounds in the VOC to be assayed.
In one implementation, the detection module can measure the collected VOCs to be detected by using gas chromatography, laser spectroscopy, or other related techniques. The detection module may measure the collected EBC to be detected by using liquid chromatography or immunoassay.
Based on the same inventive concept, the embodiment of the present invention further provides a disease detection method based on children breathing gas, and the method is applied to the server 101. Referring to fig. 3, fig. 3 is a flowchart of a method for detecting a disease based on respiratory gas of children according to an embodiment of the present invention, where the method includes:
s301, receiving a first gas parameter collected by the breath collection and detection device, sending a first control instruction to the breath collection and detection device according to the first gas parameter, so that the breath collection and detection device adjusts the temperature of the breath collection and detection device according to the first control instruction to reduce the content of water vapor in the exhaled gas, taking the gas as a gas to be collected, measuring the temperature and humidity of the gas to be collected, and sending the gas as a second gas parameter to a server.
S302, receiving the second gas parameter, sending a second control instruction to the breath collecting and detecting device according to the second gas parameter, so that the breath collecting and detecting device adjusts the temperature of the breath collecting and detecting device according to the second control instruction, collects compounds in the gas to be collected as a sample to be detected, detects the content of various target compounds in the sample to be detected, and sends the content of various target compounds as a detection result to a server.
And S303, receiving the detection result, and alarming for each target compound if the content of the target compound in the detection result is not in a preset range.
The first gas parameter is the temperature and humidity of the exhaled air of the person to be detected.
In steps S301-S303, reference may be made to the description of steps S201-S205 above in relation to the operation of the breath acquisition detection device.
In one embodiment, step S301 comprises:
step one, calculating the saturation ratio of the exhaled air according to the first temperature and the first humidity, and taking the saturation ratio as a first saturation ratio.
And step two, calculating the saturation ratio of the exhaled air according to the second temperature and the second humidity, and taking the saturation ratio as a second saturation ratio.
And step three, sending a first control instruction to the expiration collection detection equipment to enable the first saturation ratio to be smaller than 1 and the second saturation ratio to be equal to 1.
Wherein the saturation ratio is used for judging whether the exhaled air is in a saturated state.
In one embodiment, step S302 includes:
and step one, calculating the saturation ratio of the gas to be collected according to the third temperature and the third humidity as a third saturation ratio.
And step two, calculating the saturation ratio of the gas to be collected according to the fourth temperature and the fourth humidity as a fourth saturation ratio.
And step three, sending a second control instruction to the breath collecting and detecting equipment to enable the third saturation ratio to be equal to 1 and the fourth saturation ratio to be larger than 1.
In one embodiment, the assay results include the amount of the plurality of non-volatile compounds in the EBC to be assayed and the amount of the plurality of volatile compounds in the VOC to be assayed.
In the above embodiments, the implementation may be wholly or partially realized by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When loaded and executed on a computer, cause the processes or functions described in accordance with the embodiments of the invention to be performed in whole or in part. The computer may be a general purpose computer, a special purpose computer, a network of computers, or other programmable device. The computer instructions may be stored in a computer readable storage medium or transmitted from one computer readable storage medium to another, for example, from one website site, computer, server, or data center to another website site, computer, server, or data center via wired (e.g., coaxial cable, fiber optic, digital Subscriber Line (DSL)) or wireless (e.g., infrared, wireless, microwave, etc.). The computer-readable storage medium can be any available medium that can be accessed by a computer or a data storage device, such as a server, a data center, etc., that incorporates one or more of the available media. The usable medium may be a magnetic medium (e.g., floppy Disk, hard Disk, magnetic tape), an optical medium (e.g., DVD), or a semiconductor medium (e.g., solid State Disk (SSD)), among others.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising a," "8230," "8230," or "comprising" does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.
All the embodiments in the present specification are described in a related manner, and the same and similar parts among the embodiments may be referred to each other, and each embodiment focuses on differences from other embodiments.
The above description is only for the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall fall within the protection scope of the present invention.
Claims (6)
1. A child breathing gas based disease detection system comprising a server and an breath collection detection device, wherein:
the breath collecting and detecting device is used for measuring the temperature and the humidity of the exhaled gas of the person to be detected according to a preset period, and sending the temperature and the humidity as first gas parameters to the server;
the server is used for sending a first control instruction to the breath collecting and detecting equipment according to the first gas parameter;
the breath collecting and detecting device is further used for adjusting the temperature of the breath collecting and detecting device according to the first control instruction so as to reduce the content of water vapor in the exhaled air and obtain the gas to be collected; measuring the temperature and the humidity of the gas to be collected according to a preset period, and sending the temperature and the humidity as second gas parameters to the server;
the server is used for sending a second control instruction to the breath collecting and detecting equipment according to the second gas parameter;
the breath collecting and detecting device is further used for adjusting the temperature of the breath collecting and detecting device according to the second control instruction so as to collect the compound in the gas to be collected as a sample to be detected; detecting the content of a plurality of target compounds in the sample to be detected, and sending the content to the server as a detection result;
the server is also used for alarming for each target compound if the content of the target compound in the detection result is not in a preset range;
the breath collecting and detecting equipment further comprises a condenser pipe module, a first sensor module, a second sensor module and a first cooling module; the condensation pipe module comprises an unsaturated section and a supersaturated section, and when expiration collection detection is carried out, the expired gas firstly passes through the unsaturated section to obtain the gas to be collected, and then the gas to be collected passes through the supersaturated section; the first sensor module is disposed at an input end of the unsaturated segment; the second sensor module is deployed at an intersection of an output end of the undersaturation section and an input end of the supersaturation section; the first cooling module is disposed at the unsaturated section;
the first sensor module is used for collecting a first temperature and a first humidity of the exhaled air;
the second sensor module is used for acquiring a second temperature and a second humidity of the exhaled air;
the breath collecting and detecting device is used for sending the first temperature, the first humidity, the second temperature and the second humidity as first gas parameters to the server according to a preset period;
the expired air collection and detection device is specifically used for starting the first cooling module according to the first control instruction so as to enable the expired air to be in an unsaturated state, and a condensation film is formed on the inner wall of the unsaturated section so as to reduce the content of water vapor in the expired air and serve as the gas to be collected.
2. A child's breathing gas based illness detection system according to claim 1, wherein said breath collection detection device includes a gas input module and a saliva collection module;
the gas input module is used for collecting the exhaled mixture of the person to be detected;
a saliva collection module for removing saliva droplets from the exhaled mixture to obtain the exhaled air.
3. The children's breathing gas-based illness detection system of claim 1, wherein said exhaled breath collection detection apparatus further comprises a third sensor module, a second cooling module, an exhaled breath condensate EBC collection module, and a volatile organic compound, VOC, collection module; the third sensor module and the VOC acquisition module are deployed at the output end of the supersaturated section; the second cooling module is disposed in the supersaturated section; the EBC acquisition module is deployed at the intersection of the output end of the unsaturated section and the input end of the supersaturated section;
the second sensor module is used for acquiring a third temperature and a third humidity of the gas to be acquired;
the third sensor module is used for acquiring a fourth temperature and a fourth humidity of the gas to be acquired;
the breath collecting and detecting device is used for sending the third temperature, the third humidity, the fourth temperature and the fourth humidity as second gas parameters to the server according to a preset period;
the breath collection detection device is specifically configured to start the second cooling module according to the second control instruction, so that the gas to be collected is in a supersaturated state, and a condensate containing a non-volatile compound is formed on an inner wall of the supersaturated section;
the EBC acquisition module is used for acquiring the condensate as the EBC to be detected;
the VOC acquisition module is used for acquiring the gas to be acquired containing volatile compounds and used as the VOC to be detected.
4. The childhood respiratory gas-based disease detection system of claim 3, wherein the detection results comprise the content of non-volatile compounds in the EBC to be detected and the content of volatile compounds in the VOC to be detected.
5. A childhood respiratory gas-based illness detection system according to claim 3,
the server is specifically used for receiving a first gas parameter acquired by the exhaled breath acquisition and detection device, and calculating a saturation ratio of the exhaled breath according to the first temperature and the first humidity to serve as a first saturation ratio; calculating a saturation ratio of the exhaled gas as a second saturation ratio based on the second temperature and the second humidity; sending a first control instruction to the breath collection detection device to enable the first saturation ratio to be smaller than 1 and enable the second saturation ratio to be equal to 1; wherein the saturation ratio is used for judging whether the exhaled air is in a saturated state.
6. A childhood respiratory gas-based illness detection system according to claim 5,
the server is specifically configured to receive the second gas parameter, and calculate a saturation ratio of the gas to be collected according to the third temperature and the third humidity, as a third saturation ratio; calculating the saturation ratio of the gas to be collected according to the fourth temperature and the fourth humidity to serve as a fourth saturation ratio; and sending a second control instruction to the breath collection detection device to enable the third saturation ratio to be equal to 1 and enable the fourth saturation ratio to be larger than 1.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022138A (en) * | 1995-06-02 | 2000-02-08 | Sonander; Sven Olof | Method and apparatus for measuring dew point temperature of a moist gas |
| WO2021201905A1 (en) * | 2020-04-03 | 2021-10-07 | Zeteo Tech, Inc. | Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols |
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| WO2008099003A2 (en) * | 2007-02-16 | 2008-08-21 | Universiteit Maastricht | Apparatus for and method of condensing exhaled breath |
| US20200121222A1 (en) * | 2018-10-17 | 2020-04-23 | The Feinstein Institutes For Medical Research | Systems and methods for measurement of gas concentration difference between inhalation and exhalation |
| KR102543496B1 (en) * | 2019-08-26 | 2023-06-13 | 제테오 테크, 인코포레이티드 | Diagnosis of tuberculosis and other diseases using exhaled breath |
| CN114470451A (en) * | 2021-12-22 | 2022-05-13 | 安徽省立医院(中国科学技术大学附属第一医院) | Therapeutic equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022138A (en) * | 1995-06-02 | 2000-02-08 | Sonander; Sven Olof | Method and apparatus for measuring dew point temperature of a moist gas |
| WO2021201905A1 (en) * | 2020-04-03 | 2021-10-07 | Zeteo Tech, Inc. | Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols |
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