CN114522002A

CN114522002A - Close net support

Info

Publication number: CN114522002A
Application number: CN202210428751.8A
Authority: CN
Inventors: 杨新健; 刘健; 张义森; 王坤; 张莹; 李艺影
Original assignee: Beijing Neurosurgical Institute
Current assignee: Shanghai Xinwei Medical Technology Co ltd
Priority date: 2022-04-22
Filing date: 2022-04-22
Publication date: 2022-05-24
Anticipated expiration: 2042-04-22
Also published as: CN114522002B

Abstract

The invention provides a dense mesh bracket, which comprises two first components positioned at two ends of the dense mesh bracket and a second component positioned between the two first components, wherein the second component comprises one or more folding units, the folding units are in a compressed state when the dense mesh bracket is not released, and the folding units in the compressed state are in a hollow cylindrical shape; the folding units are expanded and deformed into an expanded state after the dense mesh stent is released, the folding units in the expanded state are of a multilayer structure, and the maximum diameter of the folding units in the expanded state is larger than that of the first component after the dense mesh stent is released. The dense net support has the advantages that: the applicability to fusiform or giant aneurysm is better, the adherence of the dense mesh stent in the fusiform aneurysm is increased, the second part is favorably fixed in the aneurysm, and the two ends of the dense mesh stent are prevented from contracting into the aneurysm in the stent expanding process; simple structure, need not to use extra fillers such as spring coil just can fix dense net support effectively.

Description

Close net support

Technical Field

The invention relates to the field of medical instruments, in particular to a dense mesh support.

Background

The current latest interventional therapy device for human intracranial vascular aneurysms is a dense mesh stent. The dense mesh support with small diameter and high PPI is formed by mixing and weaving superfine cobalt-cadmium-nickel alloy wires, platinum-tungsten alloy wires, nickel-titanium wires, platinum-iridium wires and the like. The dense mesh stent forms an interception barrier at the neck of the aneurysm in the blood vessel through high surface tension between meshes of the stent, so that the speed of blood flowing into the aneurysm is reduced, the flow is reduced, and the direction of the blood flow is changed. Blood flows along the lumen of the dense mesh stent, further coagulating the blood within the aneurysm volume, forming an embolic mass. The active substances in the blood vessel are attached to the surface of the dense mesh stent at the neck of the tumor, so that the surface of the dense mesh stent is endothelialized, and the effect of reconstructing the blood vessel is realized.

The diameter of the dense net stent (or called blood flow guiding device) on the market at present is the same diameter, and a few stents are open at two ends and have the same diameter in the middle. When the dense mesh stent is used at the fusiform aneurysm or huge aneurysm, the common cylindrical dense mesh stent with the same diameter is difficult to adhere to the wall in the aneurysm due to the larger inner diameter of the aneurysm, so that the dense mesh stent is difficult to fix in the aneurysm. The dense mesh stent may be displaced by blood flow within the aneurysm and by foreshortening caused by expansion of the stent itself, which may cause one or both ends of the dense mesh stent to retract into the aneurysm sac due to the displacement. In this case, the dense mesh stent may not perform a blood flow guiding function, but may cause thromboembolism, resulting in vessel occlusion or aneurysm rupture.

To address this problem, clinicians often place additional coils or the like of filler material at the aneurysm, but this procedure adds time to the procedure and also burdens the patient with the procedure.

In view of the foregoing, it would be desirable in the art to provide a dense mesh stent that overcomes the deficiencies of the prior art.

Disclosure of Invention

The invention provides a dense net support which can solve the problems in the prior art. The purpose of the invention is realized by the following technical scheme.

One embodiment of the invention provides a dense mesh bracket, which comprises two first parts and a second part, wherein the two first parts are positioned at two ends of the dense mesh bracket, the second part is positioned between the two first parts and comprises one or more folding units, the folding units are in a compressed state when the dense mesh bracket is not released, and the folding units in the compressed state are in a hollow cylindrical shape; the folding units are expanded and deformed into an expanded state after the dense mesh stent is released, the folding units in the expanded state are of a multilayer structure, and the maximum diameter of the folding units in the expanded state is larger than that of the first component after the dense mesh stent is released.

According to the dense mesh support provided by the above one embodiment of the invention, after the dense mesh support is released, the folding unit deforms to form the convex part surrounding one circle of the dense mesh support and the contraction part located on one side of the bottom of the convex part, the contraction part contracts towards the other side of the bottom of the convex part, and the top of the convex part is folded towards one side of the contraction part to form a stacked multilayer structure.

According to the dense mesh stent provided by the embodiment of the invention, the second part comprises a folding unit, and after the dense mesh stent is released, the convex part of the folding unit is folded towards the near end or the far end of the dense mesh stent.

According to the dense mesh support provided by the above one embodiment of the invention, the second part comprises a plurality of folding units, and after the dense mesh support is released, the convex parts of all the folding units are folded towards the same end of the dense mesh support.

According to the dense mesh support provided by the above one embodiment of the invention, the second component comprises a plurality of folding units, and after the dense mesh support is released, the convex parts of the folding units are respectively folded towards different ends of the dense mesh support.

According to the dense mesh stent provided by the embodiment of the invention, the maximum diameter of the second part is n times of the maximum diameter of the first part, wherein n is more than or equal to 2 and less than or equal to 5.

According to the dense-mesh stent provided by the embodiment of the invention, the dense-mesh stent is formed by weaving metal woven wires or non-metal woven wires, or by weaving metal woven wires and non-metal woven wires in a mixed manner.

According to the dense mesh stent provided by the embodiment of the invention, the folding units are separated.

According to the dense mesh stent provided by the embodiment of the invention, the folding units are partially overlapped.

Drawings

Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments with reference to the following drawings.

Figure 1 shows a side view of a dense mesh stent according to one embodiment of the present invention.

Fig. 2 shows a perspective view of the dense mesh stent according to one embodiment of the present invention as shown in fig. 1.

Fig. 3 shows a schematic cross-sectional view in direction a of the dense mesh scaffold according to an embodiment of the invention as shown in fig. 1.

Fig. 4 shows a schematic diagram of the deformation process of the dense-mesh stent after release according to one embodiment of the invention.

Fig. 5 shows a schematic view of a dense mesh stent comprising two folding units according to one embodiment of the invention.

Fig. 6 shows a schematic view of a dense mesh stent comprising two folding units according to another embodiment of the present invention.

Figure 7 shows a side view of a dense mesh stent with partial overlap between two folded units according to one embodiment of the present invention.

Fig. 8 shows a perspective view of a dense mesh stent according to an embodiment of the invention shown in fig. 7 with a partial overlap between two folding units.

Reference numbers and part names: 1-first part, 2-second part, 20-folded unit, 201-bulge, 202-constriction, 203-overlap region.

Detailed Description

The following describes embodiments of the present invention with reference to the drawings and examples, and those skilled in the art can easily understand the technical solutions, technical problems to be solved, and technical effects to be produced by the present invention through the contents described in the present specification. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not to be construed as limiting the invention. In addition, for convenience of description, only portions related to the invention are shown in the drawings.

It should be noted that the structures, ratios, sizes, and the like shown in the drawings are only used for matching with the contents described in the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions for implementing the present invention, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes fall within the scope covered by the technical contents disclosed by the present invention without affecting the effects and achievable by the present invention.

Reference to words such as "first," "second," "the," and the like do not denote a limitation of quantity, and may refer to the singular or the plural. The present invention is directed to the terms "including," "comprising," "having," and any variations thereof, which are intended to cover non-exclusive inclusions; for example, a process, method, system, article, or apparatus that comprises a list of steps or modules (elements) is not limited to the listed steps or elements, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus. The terms "connected," "coupled," and the like in the description of the present invention are not restricted to physical or mechanical connections, but may also include electrical connections, whether direct or indirect.

Figure 1 shows a side view of a dense mesh stent according to one embodiment of the present invention. Fig. 2 shows a perspective view of the dense mesh stent according to one embodiment of the present invention as shown in fig. 1. Fig. 3 shows a schematic cross-sectional view in direction a of the dense mesh scaffold according to an embodiment of the invention as shown in fig. 1. As shown in fig. 1-3, the dense mesh stent comprises two first parts 1 at two ends of the dense mesh stent and a second part 2 between the two first parts 1, the second part 2 comprises one or more folding units 20, the folding units 20 are in a compressed state when the dense mesh stent is not released, and the folding units 20 in the compressed state are in a hollow cylindrical shape; after the dense mesh stent is released, the folding units 20 are expanded and deformed into an expanded state, the folding units 20 in the expanded state are of a multilayer structure, and the maximum diameter of the folding units 20 in the expanded state is larger than that of the first component 1 after the dense mesh stent is released.

According to the dense mesh stent provided by the embodiment of the invention, after the dense mesh stent is released, the maximum diameter of the second component 2 is n times of the maximum diameter of the first component 1, wherein n is more than or equal to 2 and less than or equal to 5.

According to the dense-mesh stent provided by the above one embodiment of the invention, the dense-mesh stent is formed by weaving metal woven wires or non-metal woven wires, or by weaving metal woven wires and non-metal woven wires in a mixed manner.

According to the dense mesh stent provided by the embodiment of the invention, the metal material is a metal wire of a memory alloy material, and the metal wire comprises cobalt-chromium-nickel alloy, platinum-gold core nickel-titanium alloy, platinum-tungsten alloy and nickel-titanium alloy.

According to the dense mesh stent provided by the above one embodiment of the invention, the non-metallic material comprises polydioxanone, poly-L-lactic acid and polycaprolactone.

Fig. 4 shows a schematic diagram of the deformation process of the dense-mesh stent after release according to one embodiment of the invention. As shown in fig. 4, after the dense mesh stent is released, the folding unit 20 deforms to form a convex portion 201 surrounding the dense mesh stent for one circle and a contraction portion 202 located at one side of the bottom of the convex portion 201, the contraction portion 202 contracts towards the other side of the bottom of the convex portion 201, and the top of the convex portion 201 is folded towards one side of the contraction portion 202 to form a stacked multilayer structure.

According to the dense mesh stent provided by the above one embodiment of the present invention, after the folding unit 20 is deformed, the shrinkage of the end of the dense mesh stent located on the same side of the convex portion 201 as the shrinkage portion 202 is greater than the shrinkage of the end of the dense mesh stent located on the different side of the convex portion 201 as the shrinkage portion 202.

According to the dense mesh stent provided by the embodiment of the invention, the second component 2 comprises a folding unit 20, and the folding unit 20 is folded towards the proximal end C or the distal end B of the dense mesh stent.

According to the dense mesh stent provided by the embodiment of the invention, the far end B of the dense mesh stent refers to the end of the dense mesh stent far away from a guide wire operator when the dense mesh stent is delivered into a blood vessel; the proximal end C of the dense mesh stent refers to the end of the dense mesh stent that is near the guidewire operator when the dense mesh stent is delivered into a blood vessel.

Fig. 5 shows a schematic view of a dense mesh stent comprising two folded units according to an embodiment of the invention. As shown in fig. 5, the second member 2 includes a plurality of folding units 20, and the plurality of folding units 20 are folded toward the same end of the dense mesh stent.

According to the dense mesh stent provided by the above one embodiment of the present invention, the convex portions 201 of the plurality of folding units 20 are all folded toward the distal end B or the proximal end C of the dense mesh stent.

Fig. 6 shows a schematic view of a dense mesh stent comprising two folding units according to another embodiment of the present invention. As shown in fig. 6, wherein the second member 2 comprises a plurality of folding units 20, the plurality of folding units 20 are folded towards different ends of the dense mesh stent.

According to the dense mesh stent provided by the above one embodiment of the present invention, the convex portions 201 of some of the folded units 20 in the plurality of folded units 20 are folded toward the distal end B of the dense mesh stent, and the convex portions 201 of the remaining folded units 20 are folded toward the proximal end C of the dense mesh stent.

According to the dense mesh stent provided by the above one embodiment of the present invention, a plurality of folding units 20 are separated from one another. The folding unit 20 expands, deforms and folds to form a multilayer structure with three layers of dense nets stacked.

Figure 7 shows a side view of a dense mesh stent with partial overlap between two folded units according to one embodiment of the present invention. Fig. 8 shows a perspective view of a dense mesh stent according to an embodiment of the invention shown in fig. 7 with a partial overlap between two folding units. As shown in fig. 7 to 8, the dense mesh stent according to the above-mentioned one embodiment of the present invention is provided, in which a plurality of folding units 20 are partially overlapped with each other. The partially overlapped folded units 20 form a five-layer dense-mesh stacked multi-layer structure in the overlapping region 203.

The dense net support has the advantages that: the applicability to fusiform or huge aneurysms is better, the second part is positioned in the aneurysms when the dense mesh stent is released, the diameter of the second part is larger than that of the first part, the adherence of the dense mesh stent in the fusiform aneurysms is increased, the second part is favorably fixed in the aneurysms, the displacement of the dense mesh stent is prevented, and two ends of the dense mesh stent are prevented from contracting into the aneurysms in the stent expanding process; simple structure need not use extra filler such as spring coil and just can fix the dense net support effectively in the corresponding position in blood vessel and aneurysm, has reduced operation time, has alleviateed patient's operation burden.

While the invention has been described and illustrated with reference to specific embodiments thereof, such description and illustration are not intended to limit the invention. It will be clearly understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the true spirit and scope of the present invention as defined by the appended claims. The illustrations may not be drawn to scale. There may be a difference between the technical reproduction in the present invention and the actual equipment due to variables in the manufacturing process and the like. There may be other embodiments of the invention not specifically illustrated. The specification and drawings are to be regarded in an illustrative rather than a restrictive sense. Modifications may be made to adapt a particular situation, material, composition of matter, method, or process to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims. Although the methods disclosed herein have been described with reference to particular operations performed in a particular order, it should be understood that these operations may be combined, sub-divided, or reordered to form equivalent methods without departing from the teachings of the present disclosure. Accordingly, unless specifically indicated herein, the order and grouping of the operations is not a limitation of the present invention.

Claims

1. A dense mesh stent comprises two first components positioned at two ends of the dense mesh stent and a second component positioned between the two first components, and is characterized in that the second component comprises one or more folding units, the folding units are in a compressed state when the dense mesh stent is not released, and the folding units in the compressed state are in a hollow cylindrical shape; the folding units are expanded and deformed into an expanded state after the dense mesh stent is released, the folding units in the expanded state are of a multilayer structure, and the maximum diameter of the folding units in the expanded state is larger than that of the first component after the dense mesh stent is released.

2. The dense mesh stent of claim 1, wherein the folding unit deforms after the dense mesh stent is released to form a convex part surrounding one circle of the dense mesh stent and a contraction part located at one side of the bottom of the convex part, the contraction part contracts towards the other side of the bottom of the convex part, and the top of the convex part is folded towards one side of the contraction part to form a stacked multilayer structure.

3. The dense mesh stent of claim 2, wherein the second member comprises a folding unit, and the convex part of the folding unit is folded towards the proximal end or the distal end of the dense mesh stent after the dense mesh stent is released.

4. The dense mesh stent of claim 2, wherein the second part comprises a plurality of folding units, and the convex parts of all the folding units are folded towards the same end of the dense mesh stent after the dense mesh stent is released.

5. The dense mesh stent of claim 2, wherein the second member comprises a plurality of folding units, and the convex parts of the folding units are folded towards different ends of the dense mesh stent respectively after the dense mesh stent is released.

6. The dense mesh stent of claim 2, wherein the maximum diameter of the second member is n times the maximum diameter of the first member, wherein 2 ≦ n ≦ 5.

7. The dense mesh stent of claim 2, wherein the dense mesh stent is woven from woven wires of a metal material or woven wires of a non-metal material, or woven wires of a metal material and woven wires of a non-metal material.

8. A dense mesh stent according to any one of claims 4 to 5, wherein a plurality of folded units are separated.

9. A dense mesh stent according to any one of claims 4 to 5, wherein a plurality of folded units are partially overlapped.