CN114504521A - Emulsified composition of water-dispersed sunscreen agent - Google Patents
Emulsified composition of water-dispersed sunscreen agent Download PDFInfo
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- CN114504521A CN114504521A CN202210259728.0A CN202210259728A CN114504521A CN 114504521 A CN114504521 A CN 114504521A CN 202210259728 A CN202210259728 A CN 202210259728A CN 114504521 A CN114504521 A CN 114504521A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The present invention provides a sunscreen composition comprising the water dispersible sunscreen Tinosorb S lite Aqua, said composition being an emulsified system comprising: an emulsifier which is a combination of steareth-21 and a C14-22 alcohol/C12-20 alkyl glucoside; a thickener; grease; and water. The invention also relates to the use of a combination of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside as emulsifier in sunscreen compositions comprising the water dispersible sunscreen Tinosorb S lite Aqua, said compositions being emulsified systems which remain stable at low temperatures.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an emulsified composition containing a water dispersible sunscreen Tinosorb S lite Aqua.
Background
It is well known that ultraviolet radiation poses many health risks to humans. These include short-term hazards, as well as long-term effects. Short-term damage is mainly manifested as sunburn, suntan, sunburn; long-term effects tend to be cumulative, manifested by erythema, photoaging, photodermatosis, and even skin cancer.
Ultraviolet rays are classified into UVA, UVB, and UVC according to wavelength. UVC is almost inaccessible to the earth's surface by atmospheric barriers. Whereas UVA and UVB can partially penetrate the atmosphere to the earth's surface and cause direct damage to the skin. To reduce the damage of ultraviolet radiation to the skin, sunscreen cosmetics should be used for protection before exposure to the sun. The use of sunscreen cosmetics is the most common ultraviolet protection measure at present, can prevent erythema and sunburn induced by sunlight, prevent or reduce DNA damage, regularly use sunscreen cosmetics can also inhibit precancerous skin damage, and can obviously reduce the occurrence of solar tumors.
In recent years, the amount of sunscreen products used has been increasing with the increase in the awareness of consumers of sunscreen. The sun-screening agent is the core of sun-screening products and has a decisive influence on the performance of the sun-screening products. There has been much worry about the safety of sunscreens. First, there is a concern that the components of the sunscreen will cause some irritation to the skin. Secondly, there is a concern that some organic sunscreens may be absorbed transdermally or have potential interference with endocrine systems, but there is currently insufficient clinical data to justify these safety concerns. Therefore, the addition ratio of the sunscreen agent should be reduced as much as possible under the premise of ensuring the efficacy.
On the other hand, sunscreens leave a greasy, heavy impression on the user experience for a large part of the population. Complaints about skin feel are endless, which makes many people want to use it without use. Skin feel problems with sunscreen products are mainly due to the fact that most chemical sunscreens are greasy or oleophilic compounds. The liquid oil type sunscreen agent can be directly added and emulsified in the preparation process; however, for solid forms of sunscreen it is necessary to use other liquid oils as solvents to dissolve them before adding them to the formulation. These solid sunscreens are more stable and safer, but at the same time they have a low solubility in fats and oils. For example, bis-ethylhexyloxyphenol methoxyphenyl triazine, which is a sunscreen agent, has good stability and high safety, can protect both UVB and UVA, but has low solubility in grease. This means that when it is used, a large amount of polar oil needs to be added to dissolve first. The result is a formulation that is greasy and not refreshing in skin feel.
CN102655850A invented a novel polyglyceryl UV filter that can increase the solubility of solid sunscreens. The solubility of the bis-ethylhexyloxyphenol methoxyphenyl triazine is improved by 18 percent from 13 percent, and a plurality of (more than 5 times) thick grease is also needed to be used as a solvent, so that the improvement on the skin feeling of the formula is limited. The sunscreen product used in the patent is an aqueous dispersion prepared by dispersing and emulsifying bis-ethylhexyloxyphenol methoxyphenyl triazine, and the aqueous dispersion can be directly added into a formula, so that the problem of greasy skin feel is solved. However, the novel water-dispersible sunscreen agent also has certain application problems.
CN111050742 prepares the polymer dispersion with the average particle size less than 1000nm, and the polymer dispersion is applied to an oil-in-water system, but the system contains alcohol and is easy to cause stimulation. And it does not investigate the product stability below 0 degrees.
The novel water-dispersible sunscreen agent Tinosorb S lite Aqua is selected as a research object, and is applied to different emulsification systems to research the stability of the systems.
Disclosure of Invention
In one aspect, the present invention provides a sunscreen composition comprising the water dispersible sunscreen Tinosorb S lite Aqua, said composition being an emulsified system comprising:
an emulsifier which is a combination of steareth-21 and a C14-22 alcohol/C12-20 alkyl glucoside;
a thickener;
grease; and
and (3) water.
In a preferred embodiment, the weight ratio of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside in the sunscreen composition of the present invention is from 2:5 to 5: 2.
In a preferred embodiment, the thickener in the sunscreen composition is selected from the group consisting of: VP/acrylates/lauryl methacrylate copolymers, acrylates/vinyl isodecanoate crosspolymers, or combinations thereof. In a preferred embodiment, the oil or fat in the sunscreen composition is selected from: dioctyl carbonate, dibutyl adipate, isononyl isononanoate, or combinations thereof.
In a preferred embodiment, the sunscreen composition comprises 2-12% by weight of Tinosorb S Lite Aqua. In a preferred embodiment, the sunscreen composition comprises from 0.1 to 10% by weight of an emulsifier. In a preferred embodiment, the sunscreen composition comprises from 0.2 to 5% by weight of a thickener. In a preferred embodiment, the sunscreen composition comprises from 5 to 20% by weight of the oil.
In another aspect, the present invention provides the use of a combination of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside as emulsifier in a sunscreen composition comprising the water dispersible sunscreen Tinosorb S lite Aqua, which composition is an emulsified system which remains stable at low temperatures (e.g., -15 ℃).
Brief description of the drawings
FIG. 1 shows the results of observation of the volume using a polarizing microscope (LEICA DM2700P, 400 Xmagnification) after sampling samples for 2 weeks-15 ℃ stability.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein. For the purposes of the present invention, the following terms are defined below.
The term "about" as used herein refers to an amount, level, value, dimension, size, or amount that differs by up to 30%, 20%, or 10% as compared to the amount, level, value, dimension, size, or amount of a reference. The percentages used herein are by weight unless otherwise indicated.
Throughout the specification and claims, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
According to the present invention, the term "cosmetic" refers to a chemical industry or fine chemical product which is applied, sprayed or the like, to any part of the surface of the human body, such as skin, hair, nails, lips, and teeth, etc., for the purpose of cleaning, maintaining, beautifying, modifying and changing the appearance, or correcting the odor of the human body, and maintaining a good state.
As used herein, "sunscreen composition" refers to a formulation (e.g., lotion, spray, gel, or other topical product) that absorbs and/or reflects some of the Ultraviolet (UV) radiation of the sun and thus helps prevent the negative effects of sun exposure (e.g., sunburn, premature aging, etc.).
The invention selects Tinosorb S lite Aqua as a novel water-dispersible sunscreen agent as a research object, applies the novel water-dispersible sunscreen agent to different emulsification systems, and researches the stability of the systems (including the stability at room temperature, 4 ℃, 15 ℃, 40 ℃ and 48 ℃).
It has been surprisingly found that the emulsion system prepared with the emulsifier steareth-21 alone does not crystallize sunscreen as demonstrated by stability measurements at-15 ℃. Therefore, steareth-21 has an accelerating effect on the low temperature stability of Tinosorb S Lite Aqua.
Emulsifier
In some preferred embodiments of the present invention, the emulsifier employed in the sunscreen composition is selected from the group consisting of: steareth-21 (e.g., supplied under the trade name Eumulgin S21, BASF); potassium cetyl phosphate (e.g., available under the trade name amphsol K, DSM); c14-22 alcohol/C12-20 alkyl glucoside (e.g., as supplied under the trade name Montanov L, SEPPIC); PEG-4 polyglycerol-2 stearate (e.g., supplied under the tradename Hostacerin DGSB, Clariant); or a combination thereof.
In some embodiments, the sunscreen composition may comprise from about 0.1% to about 10% by weight of the emulsifier, based on the total weight of the composition. In some embodiments, the composition may comprise from about 0.5% to about 8% by weight of the emulsifier, based on the total weight of the composition. In some embodiments, the composition may comprise from about 0.5 to about 5 weight percent emulsifier based on the total weight of the composition. In some embodiments, the composition may comprise from about 2 to 5 weight percent emulsifier based on the total weight of the composition.
In some embodiments, the sunscreen composition may include a combination of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside as emulsifiers. In a particular embodiment, the sunscreen composition comprises from about 4% to about 5% by weight of emulsifier, based on the total weight of the composition. The composition may comprise about 4.5 wt% emulsifier based on the total weight of the composition. In a preferred embodiment, the steareth-21 is present in the sunscreen composition in an amount of no more than 4% by weight.
In some embodiments, the weight ratio of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside in the sunscreen composition is from 2:5 to 5: 2. In a particular embodiment, the weight ratio of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside in the sunscreen composition is 5: 4.
Thickening agent
In some preferred embodiments of the present invention, the thickening agent employed in the sunscreen composition is selected from the group consisting of: VP/acrylates/lauryl methacrylate copolymers (e.g., available under the trade name antraron sensor, Ashland Calvert city USA); (ii) acrylic/vinyl isodecanoate crosspolymer (supplied under the trade name Stabylen-30, 3V SIGMA); silica dimethyl silylate (trade name HDK H20, supplied by WACKER); or a combination thereof.
In some embodiments, the sunscreen composition may comprise from about 0.2% to about 5% by weight of the thickening agent, based on the total weight of the composition. The composition may comprise from about 0.2 to about 1 weight percent of a thickening agent, based on the total weight of the composition.
Oil and fat
In some preferred embodiments of the present invention, the sunscreen composition comprises an oil selected from the group consisting of: dioctyl carbonate (trade name Cetiol CC, supplied by BASF); dibutyl adipate (trade name Cetiol B, supplied by BASF); isononyl isononanoate (trade name LANOL99), supplied by SEPPIC); polydimethylsiloxane (available under the trade name Belsil DM 1PLUS, Wacker) or combinations thereof.
In some embodiments, the sunscreen composition may comprise from about 5% to about 20% by weight of the oil, based on the total weight of the composition. The composition may comprise from about 10 wt% to about 20 wt% of the oil based on the total weight of the composition.
Sunscreen agent
In some embodiments, the sunscreen composition comprises a water dispersible sunscreen. For example, sunscreen compositions comprise bis-ethylhexyloxyphenol methoxyphenyl triazine, acrylic acid/C12-22 alkanol methacrylate copolymer, arginine, coco glucoside, disodium lauryl sulfosuccinate, water (available under the trade name Tinosorb S Lite Aqua, BASF).
In some embodiments, the sunscreen composition may comprise from about 2% to about 12% by weight of the water dispersible sunscreen agent, based on the total weight of the composition. The composition may comprise from about 2 to about 10 wt% of a water dispersible sunscreen agent, based on the total weight of the composition. In a preferred embodiment, the sunscreen composition comprises from about 5% to about 8% by weight of the water dispersible sunscreen agent, based on the total weight of the composition.
In some embodiments, the sunscreen composition comprises an oil soluble sunscreen. For example, sunscreen compositions comprise ethylhexyl triazone (e.g., available under the trade name Uvinul T150, BASF); methylenebis-benzotriazoltetramethylbutylphenol (trade name Tinosorb M, supplied by BASF); ethylhexyl methoxycinnamate; ethylhexyl salicylate; or a combination thereof.
In some embodiments, the sunscreen composition may comprise from about 2 to about 20 wt% oil-soluble sunscreen, based on the total weight of the composition. The composition may comprise from about 2 to about 15 weight percent of an oil-soluble sunscreen agent, based on the total weight of the composition. In a preferred embodiment, the sunscreen composition comprises from about 2 to about 10 wt% oil-soluble sunscreen agent, based on the total weight of the composition.
In some embodiments, the sunscreen compositions of the present invention comprise a combination of a water-dispersible sunscreen and an oil-soluble sunscreen. In some embodiments, the sunscreen composition may comprise from about 2 to about 30 weight percent of one or more sunscreen agents, based on the total weight of the composition. The composition may comprise from about 2 to about 20 weight percent of one or more sunscreen agents, based on the total weight of the composition.
In some embodiments, the sunscreen compositions of the present invention comprise a combination of Tinosorb M and Tinosorb S Lite Aqua.
Topical compositions
In some embodiments, the sunscreen compositions of the present invention have a pH of 6 to 8. In a preferred embodiment, the pH of the sunscreen composition of the present invention is from 6.5 to 7.5.
The compositions may be prepared using mixing and blending methods well known in the sunscreen and cosmetic arts.
The composition may be combined with a "cosmetically acceptable topical carrier", i.e., a topical carrier capable of containing other ingredients dispersed or dissolved therein and having acceptable properties that render it safe for topical use.
The cosmetically acceptable topical carrier may optionally include a wide variety of additional oil-soluble and/or oil-dispersible materials commonly used in compositions for application to the skin at levels established in the art. For example, surfactants, emulsifiers, pearlizing or opacifying agents, thickeners, emollients, conditioning agents, humectants, chelating agents, exfoliants, preservatives, pH adjusters, and additives that enhance the appearance, feel, or fragrance of the composition, such as colorants, fragrances, tactile modifiers, and the like, may be included.
Method of use
As used herein, "topically applying" means spraying, wiping, spreading or spreading directly on the outer skin or scalp, for example, by hand or by an applicator such as a wipe, roller or spray.
The sunscreen composition may be applied to the skin of the user in any desired manner. In some aspects, the product may be applied directly by hand, or the product may be applied using a device such as a cosmetic cotton swab or other implement. The composition is advantageously applied to the skin in order to facilitate sample absorption. The composition may be left on the area to be applied for a desired level of time, such as from about 5 seconds to about 5 minutes. Alternatively, the composition may be left on the area of application and continued to be applied until absorption.
The compositions of the present invention are sprayable. As used herein, "sprayable" means that the composition, when manually actuated or released by pressurization from a dispensing mechanism such as a bottle or aerosol can having a pump spray nozzle, produces an evenly distributed and reproducible spray pattern over an area of defined shape (e.g., circular, annular) and size. The composition may be sprayable without the use of a propellant, i.e., in a non-aerosol form.
The invention will be further illustrated by the following specific examples. It should be noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as many insubstantial modifications and variations of the invention may be made by those skilled in the art in light of the above teachings. Test methods in which specific conditions are not specified in the following examples are generally carried out under conventional conditions or under conditions recommended by the manufacturer. All percentages and parts are by weight unless otherwise indicated.
Experimental materials:
sunscreen agents:
methylenebis-benzotriazoltetramethylbutylphenol, supplied by BASF (trade name Tinosorb M);
bis-ethylhexyloxyphenol methoxyphenyl triazine, acrylic acid/C12-22 alkanol methacrylate copolymer, arginine, coco glucoside, disodium lauryl sulfosuccinate, water, supplied by BASF (trade name Tinosorb S Lite Aqua);
emulsifier:
potassium cetyl phosphate, supplied by DSM (trade name amphsol K);
steareth-21, supplied by BASF (trade name Eumulgin S21);
PEG-4 polyglycerol-2 stearate, supplied by Clariant (trade name Hostacerin DGSB);
PEG-20 methyl glucose sesquistearate, available from Lubrizol (trade name glucimate SSE-20);
cetearyl olive oleate, sorbitan olive oleate, supplied by Hallstar (trade name Olivem 1000);
c14-22 alcohol/C12-20 alkyl glucoside, supplied by SEPPIC (trade name Montanov L);
thickening agent:
VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer, available from Ashland calcium city USA (trade name Antaron Sensors);
(ii) acrylic/vinyl isodecanoate crosspolymer, supplied by 3V SIGMA (trade name Stabylen-30);
grease:
dioctyl carbonate supplied by BASF (trade name Cetiol CC);
dibutyl adipate, supplied by BASF (trade name Cetiol B);
isononyl isononanoate, supplied by SEPPIC (trade name LANOL 99);
example 1: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 63.3 parts by mass of deionized water, 2.5 parts by mass of an emulsifier potassium cetyl phosphate, 0.1 part by mass of a thickener VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer and 0.1 part by mass of a thickener acrylic acid (ester)/vinyl isodecanoate cross-linked polymer.
2. Weighing oil phase raw materials: 4 parts of grease dioctyl carbonate, 12 parts of grease dibutyl adipate and 2 parts of emulsifier C14-22 alcohol/C12-20 alkyl glucoside.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 45-50 ℃, adding 7 parts by mass of a sun-screening agent Tinosorb S lite Aqua, stirring for 2-3 minutes after adding, stirring and cooling to room temperature, adding 9 parts by mass of a sun-screening agent Tinosorb M, and stirring uniformly for later use.
TABLE 1
Example 2: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 63.3 parts by mass of deionized water, 0.1 part by mass of a thickener VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer and 0.1 part by mass of a thickener acrylic acid (ester)/vinyl isodecanoate crosslinked polymer.
2. Weighing oil phase raw materials: emulsifier steareth-212.5 parts by mass, grease dioctyl carbonate 4 parts by mass, grease dibutyl adipate 12 parts by mass, and emulsifier C14-22 alcohol/C12-20 alkyl glucoside 2 parts by mass.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 45-50 ℃, adding 7 parts by mass of a sun-screening agent Tinosorb S lite Aqua, stirring for 2-3 minutes after adding, stirring and cooling to room temperature, adding 9 parts by mass of a sun-screening agent Tinosorb M, and stirring uniformly for later use.
TABLE 2
Example 3: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 63.3 parts by mass of deionized water, 0.1 part by mass of a thickener VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer and 0.1 part by mass of a thickener acrylic acid (ester)/vinyl isodecanoate crosslinked polymer.
2. Weighing oil phase raw materials: 2.5 parts of emulsifier PEG-4 polyglycerol-2 stearate, 4 parts of grease dioctyl carbonate, 12 parts of grease dibutyl adipate and 2 parts of emulsifier C14-22 alcohol/C12-20 alkyl glucoside.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 45-50 ℃, adding 7 parts by mass of a sun-screening agent Tinosorb S lite Aqua, stirring for 2-3 minutes after adding, stirring and cooling to room temperature, adding 9 parts by mass of a sun-screening agent Tinosorb M, and stirring uniformly for later use.
TABLE 3
Example 4: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 63.3 parts by mass of deionized water, 2.5 parts by mass of an emulsifier PEG-20 methyl glucose sesquistearate, 0.1 part by mass of a thickener VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer and 0.1 part by mass of a thickener acrylic acid (ester)/vinyl isodecanoate cross-linked polymer.
2. Weighing oil phase raw materials: 4 parts of grease dioctyl carbonate, 12 parts of grease dibutyl adipate and 2 parts of emulsifier C14-22 alcohol/C12-20 alkyl glucoside.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 45-50 ℃, adding 7 parts by mass of a sun-screening agent Tinosorb S lite Aqua, stirring for 2-3 minutes after adding, stirring and cooling to room temperature, adding 9 parts by mass of a sun-screening agent Tinosorb M, and stirring uniformly for later use.
TABLE 4
Example 5: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 63.3 parts by mass of deionized water, 0.1 part by mass of a thickener VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer and 0.1 part by mass of a thickener acrylic acid (ester)/vinyl isodecanoate crosslinked polymer.
2. Weighing oil phase raw materials: 2.5 parts by mass of emulsifier cetearyl alcohol olive oleate and sorbitan olive oleate, 4 parts by mass of grease dioctyl carbonate, 12 parts by mass of grease dibutyl adipate and 2 parts by mass of emulsifier C14-22 alcohol/C12-20 alkyl glucoside.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 45-50 ℃, adding 7 parts by mass of a sun-screening agent Tinosorb S lite Aqua, stirring for 2-3 minutes after adding, stirring and cooling to room temperature, adding 9 parts by mass of a sun-screening agent Tinosorb M, and stirring uniformly for later use.
TABLE 5
Test example 1: stability survey
Stability studies were performed on the samples of examples 1-5. The resulting mixture was placed in a room temperature refrigerator, a 4 ℃ refrigerator, a minus 15 ℃ refrigerator, a high temperature (40 ℃) incubator, and a high temperature (48 ℃) incubator, respectively, and the time was examined for 2 weeks. The results after the stability study are shown in the following table:
TABLE 6
And (4) conclusion: except for example 2, the coarse particles appeared in examples 1, 3, 4 and 5 after 2 weeks at-15 ℃, and the fineness of the particles was significantly reduced. The stability of example 2 is best illustrated.
Test example 2:
samples from 2 weeks to 15 ℃ stability studies were sampled and the material was observed using a polarizing microscope. The results are shown in FIG. 1.
From the results of stability examination after storage at-15 ℃ for 2 weeks, it can be found that: formulation prepared with emulsifier steareth-21 alone (example 2) showed no crystallization of sunscreen. Therefore, steareth-21 has an accelerating effect on the low temperature stability of Tinosorb S Lite Aqua compared to several other emulsifiers.
Example 6: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 70.35 parts by mass of deionized water, and 0.2 part by mass of a thickener acrylate/vinyl isodecanoate cross-linked polymer.
2. Weighing oil phase raw materials: 210.8 parts of emulsifier steareth-210, 3.5 parts of grease dioctyl carbonate, 15 parts of grease dibutyl adipate and 2 parts of emulsifier C14-22 alcohol/C12-20 alkyl glucoside.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 60 ℃, adding 0.15 mass part of tromethamine, homogenizing for 5 minutes after all the tromethamine is added
6. Cooling to 45-50 ℃, adding 8 parts by mass of a sun-screening agent Tinosorb S lite Aqua, homogenizing for 2-3 minutes after adding, stirring and cooling to room temperature for later use.
TABLE 7
Example 7: preparation of sunscreen compositions
1. Weighing water-phase raw materials: 67.15 parts by mass of deionized water, and 0.2 part by mass of a thickener acrylate/vinyl isodecanoate crosslinked polymer.
2. Weighing oil phase raw materials: emulsifier steareth-214 parts by mass, grease dioctyl carbonate 3.5 parts by mass, grease dibutyl adipate 15 parts by mass, and emulsifier C14-22 alcohol/C12-20 alkyl glucoside 2 parts by mass.
3. The water phase and the oil phase are respectively dissolved and dispersed in a water bath kettle at the temperature of 80-85 ℃.
Slowly adding the oil phase into the water phase under the condition of homogenizing at 4.80-85 ℃, and homogenizing for 5 minutes after all the oil phase is added.
5. Cooling to 60 ℃, adding 0.15 mass part of tromethamine, homogenizing for 5 minutes after all the tromethamine is added
6. Cooling to 45-50 ℃, adding 8 parts by mass of a sun-screening agent Tinosorb S lite Aqua, homogenizing for 2-3 minutes after adding, stirring and cooling to room temperature for later use.
TABLE 8
Test example 3: stability survey
Stability tests were performed on the samples of examples 2, 6, 7. The resulting mixture was placed in a room temperature refrigerator, a 4 ℃ refrigerator, a minus 15 ℃ refrigerator, a high temperature (40 ℃) incubator, and a high temperature (48 ℃) incubator, respectively, and the time was examined for 2 weeks. The results after the stability study are shown in the following table:
TABLE 9
The results show that when the emulsifier in the formula is increased to 4%, the high-temperature stability of the formula is not passed.
Application example
Application scenarios: sunscreen cream, sunscreen lotion and sunscreen spray for adults
Application example 1: preparation of sunscreen cream for adults
The process comprises the following steps: heating phase A to 80 deg.C, homogenizing, dispersing, adding phase B heated to 80 deg.C, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C, stirring, cooling to 45 deg.C, adding phase D, homogenizing for 3 min, stirring, and cooling to 35 deg.C.
Application example 2: preparation of sunscreen lotion for adults
The process comprises the following steps: heating phase A to 80 deg.C, homogenizing, dispersing, adding phase B heated to 80 deg.C, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C, stirring, cooling to 45 deg.C, adding phase D, homogenizing for 3 min, stirring, and cooling to 35 deg.C.
Application example 3: preparation of sunscreen spray for adults
The process comprises the following steps: heating phase A to 80 deg.C, homogenizing, dispersing, adding phase B heated to 80 deg.C, homogenizing for 5 min, stirring, cooling to 50 deg.C, adding phase C, stirring, cooling to 45 deg.C, adding phase D, homogenizing for 3 min, stirring, and cooling to 35 deg.C.
Claims (10)
1. A sunscreen composition comprising the water dispersible sunscreen Tinosorb S lite Aqua, said composition being an emulsified system comprising:
an emulsifier which is a combination of steareth-21 and a C14-22 alcohol/C12-20 alkyl glucoside;
a thickener;
grease; and
and (3) water.
2. A sunscreen composition according to claim 1 wherein the weight ratio of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside is from 2:5 to 5: 2.
3. The sunscreen composition of claim 1, wherein the thickening agent is selected from the group consisting of: VP/acrylates/lauryl methacrylate copolymers, acrylates/vinyl isodecanoate crosspolymers, or combinations thereof.
4. The sunscreen composition of claim 1, wherein the oil is selected from the group consisting of: dioctyl carbonate, dibutyl adipate, isononyl isononanoate, or combinations thereof.
5. A sunscreen composition according to claim 1, wherein the sunscreen composition comprises 2-12% by weight Tinosorb S Lite Aqua.
6. The sunscreen composition of claim 1, wherein the sunscreen composition comprises 0.1-10 wt% of an emulsifier.
7. The sunscreen composition of claim 1, wherein the sunscreen composition comprises 0.2-5% by weight of a thickening agent.
8. The sunscreen composition of claim 1, wherein the sunscreen composition comprises from 5 to 20% by weight of oil.
9. Use of a combination of steareth-21 and C14-22 alcohol/C12-20 alkyl glucoside as emulsifier in a sunscreen composition comprising the water dispersible sunscreen Tinosorb S lite Aqua, said composition being an emulsified system which remains stable at low temperatures.
10. Use according to claim 9, wherein the composition is stable at-15 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210259728.0A CN114504521A (en) | 2022-03-16 | 2022-03-16 | Emulsified composition of water-dispersed sunscreen agent |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210259728.0A CN114504521A (en) | 2022-03-16 | 2022-03-16 | Emulsified composition of water-dispersed sunscreen agent |
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| CN114504521A true CN114504521A (en) | 2022-05-17 |
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| CN202210259728.0A Pending CN114504521A (en) | 2022-03-16 | 2022-03-16 | Emulsified composition of water-dispersed sunscreen agent |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103402488A (en) * | 2011-02-07 | 2013-11-20 | 株式会社资生堂 | Sunscreen cosmetic |
| US20170290756A1 (en) * | 2014-09-09 | 2017-10-12 | Basf Se | Mixtures of cosmetic uv absorbers |
| CN109010087A (en) * | 2018-09-16 | 2018-12-18 | 韩后化妆品股份有限公司 | A kind of efficient sunscreen composition with cooling effect |
| CN110063901A (en) * | 2019-03-18 | 2019-07-30 | 曼秀雷敦(中国)药业有限公司 | A kind of sun-proof creams and preparation method thereof suitable for sensitive flesh |
| WO2020160267A1 (en) * | 2019-02-01 | 2020-08-06 | Beiersdorf Ag | Sunscreen compositions |
| CN111867551A (en) * | 2019-02-27 | 2020-10-30 | 株式会社Lg生活健康 | Cosmetic composition for cutting ultraviolet rays, having ultraviolet ray cutting efficiency increased by ultraviolet rays |
-
2022
- 2022-03-16 CN CN202210259728.0A patent/CN114504521A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103402488A (en) * | 2011-02-07 | 2013-11-20 | 株式会社资生堂 | Sunscreen cosmetic |
| US20170290756A1 (en) * | 2014-09-09 | 2017-10-12 | Basf Se | Mixtures of cosmetic uv absorbers |
| CN109010087A (en) * | 2018-09-16 | 2018-12-18 | 韩后化妆品股份有限公司 | A kind of efficient sunscreen composition with cooling effect |
| WO2020160267A1 (en) * | 2019-02-01 | 2020-08-06 | Beiersdorf Ag | Sunscreen compositions |
| CN111867551A (en) * | 2019-02-27 | 2020-10-30 | 株式会社Lg生活健康 | Cosmetic composition for cutting ultraviolet rays, having ultraviolet ray cutting efficiency increased by ultraviolet rays |
| CN110063901A (en) * | 2019-03-18 | 2019-07-30 | 曼秀雷敦(中国)药业有限公司 | A kind of sun-proof creams and preparation method thereof suitable for sensitive flesh |
Non-Patent Citations (1)
| Title |
|---|
| 无: "WINONA薇诺娜清透防晒乳", Retrieved from the Internet <URL:https://www.cosdna.com/chs/cosmetic_8c27463304.html> * |
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