CN114486176A - Confocal distance imaging calibration device and calibration method - Google Patents
Confocal distance imaging calibration device and calibration method Download PDFInfo
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- CN114486176A CN114486176A CN202210081863.0A CN202210081863A CN114486176A CN 114486176 A CN114486176 A CN 114486176A CN 202210081863 A CN202210081863 A CN 202210081863A CN 114486176 A CN114486176 A CN 114486176A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000005286 illumination Methods 0.000 claims abstract description 16
- 238000012014 optical coherence tomography Methods 0.000 claims description 41
- 210000004209 hair Anatomy 0.000 claims description 7
- 230000005499 meniscus Effects 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 4
- 238000004026 adhesive bonding Methods 0.000 claims description 3
- 238000010226 confocal imaging Methods 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 abstract description 3
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- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
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- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
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Abstract
The invention discloses a confocal distance imaging calibration device and a calibration method, wherein the device comprises: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera; the lighting unit emits light sources with two different wavelengths; a cross center target is arranged in the middle of the target element, and light emitted by the illumination unit is emitted into the collimating lens through the target element; the collimating lens collimates the light emitted by the lighting unit; the reflector is used for reflecting the light collimated by the collimating lens to the scanning lens unit; the scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope; the beam splitter reflects the projected light to the calibration camera. The confocal distance imaging calibration device and the confocal distance imaging calibration method have the advantages that the confocal distance adjustment is carried out on the OCT and SLO fundus imaging systems in a light spot quality analysis mode, the subjective error caused by a human eye observation method is avoided, and the calibration are more reliable. And the debugging time in the production process is saved, and the overall efficiency is improved.
Description
Technical Field
The invention relates to a confocal distance imaging calibration device and a confocal distance imaging calibration method.
Background
OCT (optical Coherence tomography) utilizes weak coherent light to generate interference, detects signals of different depth layers of tissues and obtains a three-dimensional image by scanning. Slo (scanning Laser ophthalmopy) uses linear light reflected back into the human eye to obtain detailed images of structures in the back of the eye, such as the retina, optic nerve and blood vessels. The laser light passes through the back of the eye and the reflected light is used to form an image that can be used to show changes in the eye in real time or for OCT navigation to create a three-dimensional image.
The problem of inconsistent wavelengths of OCT and SLO light paths exists in the system, and the situation is shown that when OCT imaging is optimal, SLO cannot meet the optimal imaging requirement, and conversely, when SLO imaging is optimal, OCT imaging cannot meet the optimal imaging requirement.
The existing debugging process is too subjective, depends on the subjective judgment of debugging personnel, has no certain standard basis, and causes unavoidable errors caused subjectively. In addition, the existing method needs two debuggers to complete the calibration and calibration process, which causes waste of human resources in the production process.
Disclosure of Invention
The invention provides a confocal distance imaging calibration device and a confocal distance imaging calibration method, which solve the technical problems, and specifically adopt the following technical scheme:
a confocal distance imaging calibration device is used for OCT and SLO fundus imaging systems, the OCT and SLO fundus imaging systems comprise an OCT imaging subsystem and an SLO imaging subsystem, the confocal distance imaging calibration device comprises: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera;
the illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to the propagation direction of the light path;
the calibration camera is arranged at a human eye information acquisition position of the OCT and SLO fundus imaging system and is used for simulating human eyes;
the spectroscope is arranged in a main optical path of the OCT and SLO fundus imaging system;
the lighting unit can switch and emit light sources with two different wavelengths;
a cross center target is arranged in the middle of the target element, and light emitted by the illumination unit passes through the target element and then enters the collimating lens;
the collimating lens is used for collimating the light emitted by the lighting unit;
the reflector is used for reflecting the light collimated by the collimating lens to the scanning lens unit;
the scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope;
the beam splitter reflects the projected light to the calibration camera.
Further, the lighting unit includes a mounting plate, a first light source, a second light source, a power source, and a start switch.
The first light source and the second light source are arranged on the same side of the mounting plate;
the power supply is arranged on the mounting plate and is electrically connected to the first light source and the second light source;
the starting switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source so as to be used for turning on or off the lighting unit.
Further, the lighting unit further comprises a switching on light;
the switch is arranged on the mounting plate and electrically connected to the power supply, the first light source and the second light source so as to switch the light emitting states of the first light source and the second light source.
Further, the first light source comprises a plurality of first light emitters;
the second light source includes a plurality of second light emitters.
The first and second light emitters are LEDs.
Further, the starting switch and the changeover switch are the same element.
Further, the first light source is a near-infrared light source;
the second light source is a white light source.
Further, the scanning lens unit is a double cemented lens;
the scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
Further, the refractive index of the collimator lens is 1.52;
the focal length of the collimating lens is 75 mm;
the refractive index of the convex lens is 1.56;
the refractive index of the negative meniscus concave lens is 1.62;
the focal length of the scanning lens unit is 60 mm.
A confocal distance imaging calibration method is used for the confocal distance imaging calibration device and comprises the following steps:
turning on the lighting unit, adjusting the lighting unit to emit a light source with a first wavelength, and projecting the cross hairs engraved on the target element onto a sensor of the calibration camera;
adjusting the reflector to enable the cross-hair of the target element to be superposed with the cross-hair of the system target of the OCT and SLO fundus imaging system;
adjusting the lighting unit to emit a light source of a second wavelength;
turning off a light source of the SLO imaging subsystem, turning on the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem to enable the half-peak height width of a light spot received by a sensor of the calibration camera to meet a preset condition;
and then turning on a light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem, so that the half-peak height width of the light spot received by a sensor of the calibration camera also meets the preset condition.
Further, the light source with the first wavelength is white light;
the light source of the second wavelength is near infrared light.
The confocal distance imaging calibration device and the confocal distance imaging calibration method have the beneficial effects that the confocal distance adjustment is carried out on the OCT and SLO fundus imaging systems in a light spot quality analysis mode, so that the subjective error caused by a human eye observation method is avoided, and the calibration are more reliable. And the debugging time in the production process is saved, and the overall efficiency is improved.
Drawings
FIG. 1 is a schematic diagram of a confocal distance imaging calibration apparatus of the present invention;
FIG. 2 is a schematic diagram of the confocal distance imaging calibration device of the present invention applied to OCT and SLO fundus imaging systems;
FIG. 3 is a schematic representation of a targeting element of the present invention;
FIG. 4 is a schematic view of an illumination unit of a target element of the present invention;
fig. 5 is a schematic view of a scan lens unit of the present invention.
Detailed Description
The invention is described in detail below with reference to the figures and the embodiments.
Fig. 1 shows a confocal distance imaging calibration device of the present application, which is used for adjusting OCT and SLO fundus imaging systems. As shown in fig. 2, a schematic diagram of applying the confocal distance imaging calibration device to OCT and SLO fundus imaging systems is shown, wherein the OCT and SLO fundus imaging systems include an OCT imaging subsystem and an SLO imaging subsystem. The confocal distance imaging calibration device is used for adjusting the OCT imaging subsystem and the SLO imaging subsystem to enable the OCT imaging subsystem and the SLO imaging subsystem to have a common focal length.
In this application, the confocal distance imaging calibration apparatus includes: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera. The illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to the propagation direction of the light path. The calibration camera is arranged at the human eye information acquisition position of the OCT and SLO fundus imaging system and is used for simulating human eyes. The spectroscope is arranged in a main optical path of the OCT and SLO fundus imaging system.
In particular, the lighting unit is switchable to emit light sources of two different wavelengths. The middle of the target element is provided with a cross-shaped central target, and light emitted by the illumination unit passes through the target element and then enters the collimating lens, as shown in fig. 3. The collimating lens is used for collimating the light emitted by the illumination unit. The reflector is used for reflecting the light collimated by the collimating lens to the scanning lens unit. The scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope. The beam splitter reflects the projected light to the calibration camera.
The adjusting method of the confocal distance imaging calibration device comprises the following steps: the illumination unit is turned on, adjusted to emit a light source of a first wavelength, projecting a cross hair engraved on the target element onto the sensor of the calibration camera. The center line scale of the target pattern provides a calibration position for adjusting the center spot. Specifically, there is also a cross center system target in front of the calibration camera. And adjusting the reflector to enable the cross hairs of the target element to be superposed with the cross hairs of the system target of the OCT and SLO fundus imaging system. The lighting unit is tuned to emit a light source of a second wavelength. And turning off a light source of the SLO imaging subsystem, turning on the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem so that the half-peak height width of a light spot received by a sensor of the calibration camera meets a preset condition. And then turning on a light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem, so that the half-peak height width of the light spot received by a sensor of the calibration camera also meets the preset condition. At the moment, the imaging positions of the two optical paths meet the requirement of confocal distance, namely the confocal distance adjustment of the OCT and SLO fundus imaging systems is completed.
The method for measuring the half-peak height and width is an industry universal means, so that the half-peak height and width meets the value required by the actual use of the system, and the specific value is determined according to the system requirement, and is not detailed here.
As shown in fig. 4, the lighting unit includes a mounting plate, a first light source, a second light source, a power source, and a start switch. The first light source and the second light source are arranged on the same side of the mounting plate. The power supply is arranged on the mounting plate and electrically connected to the first light source and the second light source. The starting switch is arranged on the mounting plate and is electrically connected to the power supply, the first light source and the second light source so as to be used for turning on or off the lighting unit.
Preferably, the lighting unit further comprises a switch-on light. The switch is arranged on the mounting plate and electrically connected to the power supply, the first light source and the second light source so as to switch the light emitting states of the first light source and the second light source.
In this application, the first light source comprises a plurality of first light emitters. The second light source includes a plurality of second light emitters. The first and second light emitters are LEDs. Wherein, the first light source is a near-infrared light source. The second light source is a white light source.
Specifically, the first light source and the second light source are arranged as shown in the figure, wherein 1, 3, 5, 7 and 9 are near-infrared LEDs, and 2, 4, 6 and 8 are white LEDs.
In the present application, the starting switch and the changeover switch are one and the same element. In the initial state, both the near-infrared LED and the white LED are turned off. The white light LED is turned on when the selector switch is pressed once, the white light LED is turned off and the near-infrared LED is turned on when the selector switch is pressed for the second time, and the near-infrared LED is turned off when the selector switch is pressed for the third time. Thus, one start switch member can be reduced.
As a preferred embodiment, the scanning lens unit is a double cemented lens, as shown in fig. 5. Specifically, the scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
Preferably, in the present application, the refractive index of the collimator lens is 1.52, and the focal length of the collimator lens is 75 mm. The refractive index of the convex lens is 1.56, and the refractive index of the negative meniscus concave lens is 1.62. The focal length of the scanning lens unit is 60 mm.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.
Claims (10)
1. A confocal distance imaging calibration device is used for an OCT (optical coherence tomography) and SLO (slit optical coherence tomography) fundus imaging system, wherein the OCT and SLO fundus imaging system comprises an OCT imaging subsystem and an SLO imaging subsystem, and the confocal distance imaging calibration device comprises: the device comprises an illumination unit, a target element, a collimating lens, a reflecting mirror, a scanning lens unit, a spectroscope and a calibration camera;
the illumination unit, the target element, the collimating lens, the reflecting mirror, the scanning lens unit, the spectroscope and the calibration camera are sequentially arranged according to a light path propagation direction;
the calibration camera is arranged at a human eye information acquisition position of the OCT and SLO fundus imaging system and is used for simulating human eyes;
the spectroscope is arranged in a main optical path of the OCT and SLO fundus imaging system;
the lighting unit can be switched to emit light sources with two different wavelengths;
a cross central target is arranged in the middle of the target element, and light emitted by the illumination unit passes through the target element and then is emitted into the collimating lens;
the collimating lens is used for collimating the light emitted by the lighting unit;
the reflector is used for reflecting the light collimated by the collimating lens to the scanning lens unit;
the scanning lens unit is used for projecting the light reflected by the reflecting mirror to the spectroscope;
the spectroscope reflects the projected light to the calibration camera.
2. The confocal imaging calibration apparatus of claim 1,
the lighting unit includes a mounting plate, a first light source, a second light source, a power source, and a start switch.
The first light source and the second light source are arranged on the same side of the mounting plate;
the power supply is arranged on the mounting plate and is electrically connected to the first light source and the second light source;
the start switch is disposed on the mounting plate and electrically connected to the power source, the first light source and the second light source for turning on or off the lighting unit.
3. The confocal imaging calibration apparatus according to claim 2,
the lighting unit further comprises a switching on light;
the switch is disposed on the mounting plate and electrically connected to the power source, the first light source and the second light source for switching a light emitting state of the first light source and the second light source.
4. The confocal imaging calibration apparatus of claim 3,
the first light source comprises a plurality of first light emitters;
the second light source includes a plurality of second light emitters.
The first and second light emitters are LEDs.
5. The confocal imaging calibration apparatus of claim 3,
the starting switch and the change-over switch are the same element.
6. The confocal imaging calibration apparatus of claim 1,
the first light source is a near-infrared light source;
the second light source is a white light source.
7. The confocal imaging calibration apparatus of claim 1,
the scanning lens unit is a double-cemented lens;
the scanning lens unit is formed by gluing a convex lens and a negative meniscus concave lens.
8. The confocal imaging calibration apparatus of claim 7,
the refractive index of the collimating lens is 1.52;
the focal length of the collimating lens is 75 mm;
the refractive index of the convex lens is 1.56;
the refractive index of the negative meniscus concave lens is 1.62;
the focal length of the scanning lens unit is 60 mm.
9. A confocal distance imaging calibration method for the confocal distance imaging calibration apparatus of claim 1, comprising the steps of:
turning on the illumination unit, adjusting the illumination unit to emit a light source with a first wavelength, and projecting the cross hairs engraved on the target element onto a sensor of the calibration camera;
adjusting the mirror to cause the cross hairs of the target element to coincide with the cross hairs of the system target of the OCT and SLO fundus imaging systems;
adjusting the lighting unit to emit a light source of a second wavelength;
turning off a light source of the SLO imaging subsystem, turning on the light source of the OCT imaging subsystem, and adjusting the focal length position of a first collimating lens of the OCT imaging subsystem, so that the half-peak height width of a light spot received by a sensor of the calibration camera meets a preset condition;
and then turning on the light source of the SLO imaging subsystem, turning off the light source of the OCT imaging subsystem, and adjusting the focal length position of a second collimating lens of the SLO imaging subsystem, so that the half-peak height and width of the light spot received by the sensor of the calibration camera also meet the preset conditions.
10. The confocal distance imaging calibration method according to claim 9,
the light source with the first wavelength is white light;
the light source of the second wavelength is near infrared light.
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