CN114467974A - Bacteriostatic agent copper sulfate effervescent tablet for dissolution instrument - Google Patents
Bacteriostatic agent copper sulfate effervescent tablet for dissolution instrument Download PDFInfo
- Publication number
- CN114467974A CN114467974A CN202210078413.6A CN202210078413A CN114467974A CN 114467974 A CN114467974 A CN 114467974A CN 202210078413 A CN202210078413 A CN 202210078413A CN 114467974 A CN114467974 A CN 114467974A
- Authority
- CN
- China
- Prior art keywords
- copper sulfate
- effervescent
- acid
- effervescent tablet
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 title claims abstract description 43
- 229910000365 copper sulfate Inorganic materials 0.000 title claims abstract description 40
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 25
- 238000004090 dissolution Methods 0.000 title abstract description 11
- 239000000022 bacteriostatic agent Substances 0.000 title abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000894006 Bacteria Species 0.000 claims abstract description 13
- 239000000314 lubricant Substances 0.000 claims abstract description 10
- 239000007884 disintegrant Substances 0.000 claims abstract description 8
- 239000003085 diluting agent Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 15
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 15
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 12
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 230000003385 bacteriostatic effect Effects 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 239000000084 colloidal system Substances 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 4
- 241000530268 Lycaena heteronea Species 0.000 abstract description 2
- 230000012010 growth Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 11
- 239000008118 PEG 6000 Substances 0.000 description 8
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 8
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 8
- 239000003826 tablet Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 238000010008 shearing Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000005739 Bordeaux mixture Substances 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 229910052927 chalcanthite Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- CRPOUZQWHJYTMS-UHFFFAOYSA-N dialuminum;magnesium;disilicate Chemical compound [Mg+2].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] CRPOUZQWHJYTMS-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000006799 invasive growth in response to glucose limitation Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
Abstract
The invention discloses a dissolution instrument bacteriostatic agent copper sulfate effervescent tablet. The invention relates to blue copper sulfate effervescent tablets and a preparation method thereof. The copper sulfate effervescent tablet contains auxiliary materials such as copper sulfate, effervescent disintegrant, lubricant, diluent and the like, and the selection of proper effervescent disintegrant and lubricant is the key for ensuring the stable quality of the effervescent tablet preparation. The invention has the advantages of few auxiliary materials, high disintegration speed and easy water dissolution, can inhibit the growth of bacteria in water and can prolong the service life of the water.
Description
Technical Field
The invention belongs to the field of pharmaceutical preparations, and relates to a dissolution instrument bacteriostatic agent copper sulfate effervescent tablet.
Background
Since the water in the tank of the dissolution apparatus is generally at about 37 ℃, bacteria easily grow, the tank becomes dirty, and the dissolution phenomenon may not be observed clearly.
Copper sulfate (copper sulfate) is an inorganic compound with antibacterial and bactericidal effects, and has chemical formula of CuSO4. Is white or off-white powder,the aqueous solution was weakly acidic and blue. Blue copper sulfate pentahydrate (CuSO4 & 5H2O, also known as chalcanthite) is formed when crystallized from an aqueous solution, and this principle can be used to test for the presence of water. The crystal water is decomposed after being heated and lost, is stable at normal temperature and normal pressure, does not deliquesce, and can be gradually weathered in dry air.
Copper sulfate is an important raw material for preparing other copper-containing compounds. Mixing with lime milk to obtain Bordeaux mixture as bactericide. Also used as an electrolyte in electrolytic refining of copper.
The copper sulfate effervescent tablet has the following defects that the temperature and the humidity need to be controlled in the preparation process, the copper sulfate has toxicity, and a mask and gloves need to be worn in the operation process.
Disclosure of Invention
The invention provides an effervescent tablet solid preparation which has the functions of bacteriostasis and sterilization of copper sulfate, is convenient to use and takes effect quickly. The copper sulfate effervescent tablet comprises the following components in parts by mass:
100-300 parts by mass of an effervescent disintegrant;
10-50 parts by mass of a lubricant;
10-20 parts by mass of a binder;
100-200 parts by mass of a diluent;
and 500 parts of copper sulfate.
In the copper sulfate effervescent tablet, the effervescent disintegrant comprises an organic acid source, a carbon dioxide source and colloidal magnesium aluminum silicate;
the acid source is at least one selected from citric acid, adipic acid, malic acid, boric acid, tartaric acid, fumaric acid and hydrochloric acid;
the carbon dioxide source is selected from at least one of sodium bicarbonate, sodium carbonate, potassium carbonate and potassium bicarbonate;
the dosage of the colloidal magnesium aluminum silicate is 1-2% of the total mass of the organic acid source and the carbon dioxide source.
The lubricant is a water-soluble lubricant; specifically polyethylene glycol 6000.
The adhesive is at least one of water, ethanol, polyvinylpyrrolidone (PVP) water solution and ethanol solution;
the wetting agent is 5% PVP absolute ethanol solution.
The method for preparing the copper sulfate effervescent tablet comprises the following steps: mixing the given components according to a ratio, granulating, drying and tabletting to obtain the finished product.
The application of the copper sulfate effervescent tablets in bacteriostasis and/or sterilization also belongs to the protection scope of the invention.
In the bacteriostasis and sterilization, the bacteria are derived from at least one of protozoa and lower algae with colloid.
The copper sulfate effervescent tablet provided by the invention contains auxiliary materials such as copper sulfate, an effervescent disintegrant, a lubricant, a diluent and the like, and the selection of a proper effervescent disintegrant and a proper lubricant is the key for ensuring the stable quality of the effervescent tablet preparation. The invention has the advantages of few auxiliary materials, high disintegration speed and easy water dissolution, can inhibit the growth of bacteria in water and can prolong the service life of the water.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples, but the present invention is not limited to the following examples. The method is a conventional method unless otherwise specified. The starting materials are commercially available from the open literature unless otherwise specified. The colloidal magnesium aluminum silicate used in the examples described below was purchased from Hubei forgiving Biotechnology Limited, CAS No. 71205-22-6.
Example 1
The invention provides an effervescent tablet solid preparation which has the functions of bacteriostasis and sterilization of copper sulfate, is convenient to use and takes effect quickly.
[ prescription ]
| Components | In an amount of mg |
| Copper sulfate | 250 |
| Tartaric acid | 300 |
| 5% PVP absolute ethanol solution | 2.5 |
| PEG6000 | 1.5 |
| Components | In an amount of mg |
| Copper sulfate | 250 |
| Sodium bicarbonate | 200 |
| 5% PVP absolute ethanol solution | 2.5 |
| PEG6000 | 1.5 |
| Colloidal magnesium aluminum silicate | 5 |
[ PREPARATION METHOD ] A
And (3) granulating: adding copper sulfate, tartaric acid, PEG6000 and 5% PVP (polyvinyl pyrrolidone) absolute ethanol solution into a wet granulator for granulation (stirring parameter 100rpm, and shearing parameter 1500 rpm); drying (air inlet temperature is 60 ℃), adding copper sulfate, sodium bicarbonate, PEG6000, 5% PVP absolute ethanol solution and colloidal magnesium aluminum silicate into a wet granulator for granulation (stirring parameter is 100rpm, and shearing parameter is 1500rpm), drying, granulating (400hz) by using a granulator, uniformly mixing, and tabletting to obtain the copper sulfate effervescent tablet. Each tablet weighs about 1.0 g/tablet, and the hardness is 60N. After tabletting, the test was conducted for hardness, friability, disintegration, and the like.
Example 2
[ prescription ]
| Components | In an amount of mg |
| Copper sulfate | 250 |
| Tartaric acid | 350 |
| 5% PVP absolute ethanol solution | 3 |
| PEG6000 | 1 |
| Components | In an amount of mg |
| Copper sulfate | 250 |
| Sodium bicarbonate | 150 |
| 5% PVP absolute ethanol solution | 3 |
| PEG6000 | 1 |
| Colloidal magnesium aluminum silicate | 5 |
[ PREPARATION METHOD ]
And (3) granulating: adding copper sulfate, tartaric acid, PEG6000 and 5% PVP absolute ethanol solution into a wet granulator for granulation (stirring parameter 100rpm, shearing parameter 1500 rpm); drying (air inlet temperature is 60 ℃), adding copper sulfate, sodium bicarbonate, PEG6000, 5% PVP and colloidal magnesium aluminum silicate anhydrous ethanol solution into a wet granulator for granulation (stirring parameter is 100rpm, shearing parameter is 1500rpm), drying, granulating (400hz) by using a granulator, mixing uniformly, and tabletting to obtain the copper sulfate effervescent tablet. Each tablet weighs about 1.0 g/tablet, and the hardness is 60N. After tabletting, the test was conducted for hardness, friability, disintegration, and the like.
The evaluation and results of bacteriostasis and sterilization of the product obtained in the above example are as follows:
comparing the dissolution instrument water tank without the product with the dissolution instrument water tank with the product, wherein the comparison is divided into two groups: one set was four tablets without comparative addition to formula 1 and two were four doses without comparative addition to formula 2. The appearance and the degree of contamination of the dissolution apparatus water were observed after one month.
Disintegration time limit:
referring to the general rule of the fourth part of the 'Chinese pharmacopoeia' 2015 edition < 0921: the disintegration time limit detection method > measures the disintegration condition of the copper sulfate effervescent tablets:
the product is compared with benzalkonium bromide to detect the bacteriostatic activity of copper sulfate in water, the experiment is that the test is carried out by comparing two bacteriostatic agents with different concentrations, the test is placed for 7 days and 14 days, then the total number of bacteria is counted, a sample is processed, diluted to a proper concentration, and cultured under a certain condition (culture medium, culturing at the temperature of 30 +/-1 ℃ for 72 +/-3 h and the like), and the total number of bacteria contained in 1g (mL) of the sample is obtained. The antibacterial activity is judged.
Calculation of total number of bacteria:
when the plate colony is counted, the plate colony can be observed by naked eyes, and if the colony morphology is small, the observation can be carried out by a magnifying glass. After counting the total number of bacteria on each plate, the average of two plate colonies at the same dilution was determined.
Plates with a total of bacteria between 30-300 were selected for total bacteria determination, using an average of two plate colonies per dilution. One of the two plates is not suitable for being used when the larger flaky bacterial colony grows; if the plate-shaped colonies are less than half of the plate and the other half of the plate colonies are uniformly distributed, the half plate colonies can be calculated and multiplied by 2 to represent the total bacteria number of the whole plate.
The statistical results are as follows:
through the examination of the bacteriostatic activity, the copper sulfate has a good effect of inhibiting the total number of bacteria.
Claims (7)
1. A copper sulfate effervescent tablet comprises the following components in parts by mass:
100-300 parts by mass of an effervescent disintegrant;
10-50 parts by mass of a lubricant;
10-20 parts by mass of a binder;
100-200 parts by mass of a diluent;
and 500 parts of copper sulfate.
2. The copper sulfate effervescent tablet of claim 1, wherein: the effervescent disintegrant comprises an organic acid source, a carbon dioxide source and colloidal magnesium aluminum silicate;
the acid source is at least one selected from citric acid, adipic acid, malic acid, boric acid, tartaric acid, fumaric acid and hydrochloric acid;
the carbon dioxide source is selected from at least one of sodium bicarbonate, sodium carbonate, potassium carbonate and potassium bicarbonate;
the dosage of the colloidal magnesium aluminum silicate is 1-2% of the total mass of the organic acid source and the carbon dioxide source.
3. Copper sulfate effervescent tablets according to claim 1 or 2, characterized in that: the lubricant is a water-soluble lubricant; in particular polyethylene glycol 6000.
4. A copper sulfate effervescent tablet as claimed in any one of claims 1 to 3, wherein: the adhesive is selected from at least one of water, ethanol, polyvinylpyrrolidone (PVP) water solution and ethanol solution;
the wetting agent is 5% PVP absolute ethanol solution.
5. A process for preparing a copper sulfate effervescent tablet as defined in any one of claims 1-4, comprising: mixing the given components according to a ratio, granulating, drying and tabletting to obtain the finished product.
6. Use of copper sulphate effervescent tablets as claimed in any one of claims 1 to 4 for bacteriostatic and/or bactericidal purposes.
7. Use according to claim 6, characterized in that: in the bacteriostasis and sterilization, the bacteria are derived from at least one of protozoa and lower algae with colloid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210078413.6A CN114467974A (en) | 2022-01-24 | 2022-01-24 | Bacteriostatic agent copper sulfate effervescent tablet for dissolution instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210078413.6A CN114467974A (en) | 2022-01-24 | 2022-01-24 | Bacteriostatic agent copper sulfate effervescent tablet for dissolution instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114467974A true CN114467974A (en) | 2022-05-13 |
Family
ID=81473924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210078413.6A Pending CN114467974A (en) | 2022-01-24 | 2022-01-24 | Bacteriostatic agent copper sulfate effervescent tablet for dissolution instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114467974A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB121590A (en) * | 1917-12-20 | 1919-08-14 | Jean Urruty | Composition for Cleaning Condenser Tubes and the like. |
| FR1070602A (en) * | 1952-11-26 | 1954-08-03 | Method for performing rapid analyzes of physiological fluids, in particular urine | |
| JPH0585901A (en) * | 1991-09-26 | 1993-04-06 | Hokko Chem Ind Co Ltd | Foamable agricultural chemical formulation for application on water surface |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| JPH06183903A (en) * | 1992-12-24 | 1994-07-05 | Haiponetsukusu Japan:Kk | Foaming tablet for life prolongation of cut flower |
| CN1268885A (en) * | 1997-09-02 | 2000-10-04 | 尤尼利弗公司 | Oral compositions |
| CN105130677A (en) * | 2015-09-15 | 2015-12-09 | 南京农业大学 | Water-culture flower nutrient solution concentrated effervescent tablet formula and preparation method thereof |
-
2022
- 2022-01-24 CN CN202210078413.6A patent/CN114467974A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB121590A (en) * | 1917-12-20 | 1919-08-14 | Jean Urruty | Composition for Cleaning Condenser Tubes and the like. |
| FR1070602A (en) * | 1952-11-26 | 1954-08-03 | Method for performing rapid analyzes of physiological fluids, in particular urine | |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| JPH0585901A (en) * | 1991-09-26 | 1993-04-06 | Hokko Chem Ind Co Ltd | Foamable agricultural chemical formulation for application on water surface |
| JPH06183903A (en) * | 1992-12-24 | 1994-07-05 | Haiponetsukusu Japan:Kk | Foaming tablet for life prolongation of cut flower |
| CN1268885A (en) * | 1997-09-02 | 2000-10-04 | 尤尼利弗公司 | Oral compositions |
| CN105130677A (en) * | 2015-09-15 | 2015-12-09 | 南京农业大学 | Water-culture flower nutrient solution concentrated effervescent tablet formula and preparation method thereof |
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Application publication date: 20220513 |