CN114453041A

CN114453041A - Micro-droplet preparation device

Info

Publication number: CN114453041A
Application number: CN202210227557.3A
Authority: CN
Inventors: 江帆; 颜举; 黄君宏; 谢宝山
Original assignee: Guangzhou University
Current assignee: Guangzhou University
Priority date: 2022-03-08
Filing date: 2022-03-08
Publication date: 2022-05-10

Abstract

The invention provides a micro-droplet preparation device, which relates to the technical field of droplet preparation and comprises a liquid injection pipe, wherein a collection vessel is arranged below the liquid injection pipe, a top plate is arranged on one side of the liquid injection pipe, and the liquid injection pipe is connected with the top plate through a linear reciprocating driving device; the liquid injection pipe is controlled to do linear reciprocating motion by the linear reciprocating driving device, so that liquid drops can be thrown out by using the inertia force of the motion of the fluid, and the liquid injection pipe has the advantages of simple structure, easiness in manufacturing and low cost; the size of the micro-droplets can be controlled by controlling the speed of the linear reciprocating driving device and the diameter of the liquid injection pipe, the preparation method is simple and clear, a flow channel structure does not need to be additionally designed, and the compatibility is high.

Description

Micro-droplet preparation device

Technical Field

The invention relates to the technical field of droplet preparation, in particular to a micro-droplet preparation device.

Background

The micro-droplets can be widely applied in the fields of chemical engineering, biological medical treatment and the like. The preparation of the liquid drops mainly comprises an active preparation method and a passive preparation method. The principle of the active method for preparing the liquid drops is that external force acts on fluid to generate pressure difference, and the shearing force and the surface tension difference of the fluid are utilized to form the liquid drops. The passive method for preparing liquid drops mainly generates liquid drops in a focusing mode through the design of a flow channel structure. Compared with a passive preparation method, the active preparation method does not need elaborate micro-pipeline structure design and has enlarged precision range.

Although the active method has better control efficiency on the generation of the liquid drops, the active method has higher requirements on the device and the material of the device, thereby invisibly increasing the experimental difficulty and the cost. For example, patent "CN 104741158A-a method and device for generating micro-droplets by using inertial force", which obtains the inertial force through a centrifuge, and simultaneously generates droplets by using the surface tension of the fluid itself, has the disadvantages of high use cost and complicated operation. Patent "CN 113769808A-a rotary drop generator", this patent technology uses a crank-link mechanism to make a circular motion of a fluid and combine the interfacial shear force of the fluid to cut off the drops. However, the PDMS material is needed in the patent, which is relatively expensive, and the flow channel needs to be carved on the material, and the cost of the flow channel design needs to be increased.

Disclosure of Invention

The invention aims to provide a micro-droplet preparation device, which can prepare micro-droplets in a simpler operation mode and at lower manufacturing cost;

the invention provides a micro-droplet preparation device which comprises an injection pipe, wherein a collection vessel is arranged below the injection pipe, a top plate is arranged on one side of the injection pipe, and the injection pipe is connected with the top plate through a linear reciprocating driving device.

Further, the linear reciprocating driving device comprises an electromagnetic driving system and a spring return system.

Further, the electromagnetic driving system comprises an electromagnet and a permanent magnet, the electromagnet is fixed on the top plate, and the permanent magnet is fixed on the liquid injection pipe.

Furthermore, the spring reset system comprises at least two reset springs, the two reset springs are respectively positioned on two sides of the electromagnetic driving system, and two ends of each reset spring are respectively connected with the top plate and the liquid injection pipe.

Further, the collection ware includes transition case and drawer case, the transition case is located annotate the below of liquid pipe and be equipped with the collection mouth, the drawer case activity sets up transition bottom of the case portion.

Furthermore, the top of transition box is equipped with the case lid, it is located to collect the mouth on the case lid, it is equipped with the spout to lie in on the case lid one side of collecting the mouth, one side of annotating the liquid pipe is connected with the slide bar, the slide bar slidable insert in the spout.

Further, the liquid injection pipe comprises an inner phase input pipe and an outer phase input pipe, and the outer phase input pipe is wrapped on the inner phase input pipe in a spiral surrounding mode.

Furthermore, the top plate comprises a fixed plate and a positioning plate, the positioning plate is arranged on one side, close to the liquid injection pipe, of the fixed plate in a sliding mode, and the linear reciprocating driving device is connected with the positioning plate.

Furthermore, a positioning groove is formed in one side, close to the liquid injection pipe, of the fixing plate, the positioning plate is arranged in the positioning groove in a sliding mode, a locking nut is arranged on one side, far away from the liquid injection pipe, of the fixing plate, and the locking nut penetrates through the fixing plate and is locked with the positioning plate.

Further, the bottom end of the top plate is connected with the collecting dish through a hinge mechanism.

According to the technical scheme, the linear reciprocating motion of the liquid injection pipe is controlled by using the linear reciprocating driving device, so that liquid drops can be thrown out by using the inertia force generated by the motion of fluid, the structure is simple, the manufacturing is easy, and the cost is low; the size of the micro-droplets can be controlled by controlling the speed of the linear reciprocating driving device and the diameter of the liquid injection pipe, the preparation method is simple and clear, a flow channel structure does not need to be additionally designed, and the compatibility is high.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic illustration of an explosive structure according to the present invention;

FIG. 3 is a schematic view of the linear reciprocating drive of the present invention;

FIG. 4 is a schematic view of a slide bar of the present invention;

FIG. 5 is a cross-sectional view of the invention of FIG. 4;

FIG. 6 is a schematic view of the hinge mechanism of the present invention;

FIG. 7 is a cross-sectional view of the lid of the present invention;

FIG. 8 is a schematic diagram of the voltage cycling of the electromagnet of the present invention;

FIG. 9 is a schematic representation of a single emulsion of the present invention prior to preparation;

FIG. 10 is a schematic representation of a single emulsion after preparation in accordance with the present invention;

FIG. 11 is a schematic representation of the double emulsion of the present invention prior to preparation;

FIG. 12 is a schematic representation of a double emulsion of the invention after preparation;

FIG. 13 is a schematic view of the liquid pouring spout of the present invention before it is tilted for preparation;

FIG. 14 is a schematic view of the pouring spout of the present invention after it has been tilted;

FIG. 15 is a schematic view of the injection tube of the present invention before horizontal preparation;

FIG. 16 is a schematic view of the injection tube of the present invention after horizontal preparation;

FIG. 17 is a schematic view of the present invention employing retractable sleeve retraction;

FIG. 18 is a schematic view of the present invention using telescoping tubes for extension;

description of reference numerals:

1-liquid injection pipe, 101-internal phase input pipe, 102-external phase input pipe, 103-liquid inlet, 104-micro-liquid drop outlet

2-collection vessel, 201-transition box, 202-drawer box and 203-drainage tube

3-top plate, 301-fixing plate, 302-positioning plate, 303-positioning groove, 304-locking nut,

4-electromagnetic driving system, 401-electromagnet, 402-permanent magnet,

5-spring return system, 501-return spring,

6-telescopic sleeve,

7-box cover, 701-collection port, 702-chute,

8-sliding rod, 801-pulley,

9-hinge mechanism, 10-microdroplet, 11-double emulsion;

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise. Furthermore, the terms "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Example 1

As shown in figures 1 and 2, the invention provides a micro-droplet preparation device, which comprises an injection tube 1, a collecting vessel 2 is arranged below the injection tube 1, a top plate 3 is arranged on one side of the injection tube 1, and the injection tube 1 is connected with the top plate 3 through a linear reciprocating driving device.

Specifically, the liquid filling pipe 1 is a vertically arranged pipe, the upper part of which is provided with a liquid inlet 103 for connecting with a liquid container, and the lower part of which is provided with a micro-droplet outlet 104. The linear reciprocating driving device drives the liquid injection pipe 1 to do linear reciprocating motion, the liquid in the liquid injection pipe 1 moves along with the linear reciprocating driving device and accumulates inertia force, when the liquid flows out from the micro-droplet outlet 104, the carried inertia force causes the liquid to form shearing force with the liquid injection pipe 1, and the liquid flows down in a droplet shape, thereby forming micro-droplets 10; when the micro-droplets 10 leave from the micro-droplet outlet 104 at the lower part of the liquid injection pipe 1, the micro-droplets enter the collection dish 2 below under the action of gravity to be collected; it is expected that when the movement speed of the pouring spout 1 is increased, that is, the inertial force of the liquid is increased, the drop diameter of the liquid drops will be made smaller because the dropping speed thereof by the influence of gravity in the pouring spout 1 is constant. The linear reciprocating driving device can be a pneumatic telescopic rod, a cam mechanism, a crank connecting rod and the like, and only needs to drive the liquid injection pipe 1 to reciprocate. The top plate 3 is positioned at one side of the liquid injection pipe 1 and the collecting vessel 2 and used for providing a fixed and installed foundation for the linear reciprocating driving device, the top plate 3 is fixed in the using process, and the linear reciprocating driving device connected with the top plate 3 controls the movement of the liquid injection pipe 1.

In addition, in the present embodiment 1, the liquid pouring spout 1 is not limited to be vertically disposed, and may be disposed obliquely, as long as the effect of preparing the micro-droplets 10 can be achieved similarly.

Example 2

The present embodiment 2 further describes a linear reciprocating driving device:

as shown in fig. 1, the linear reciprocating drive apparatus includes an electromagnetic drive system 4 and a spring return system 5. Specifically, in the embodiment 2, the linear reciprocating driving device is actively driven by the electromagnetic driving system 4, and is driven and reset by the spring resetting system 5, so as to realize reciprocating driving.

As shown in FIGS. 2, 3 and 5, the electromagnetic drive system 4 comprises an electromagnet 401 and a permanent magnet 402, wherein the electromagnet 401 is fixed on the top plate 3, and the permanent magnet 402 is fixed on the pour spout 1. Specifically, the coil current in the electromagnet 401 is controllable, the coil current is alternating current, the current direction is periodically changed and controllable, so that the electrode of the electromagnet 401 changes along with the period, the electrode of the other permanent magnet 402 is kept unchanged, the periodic opening and closing of the electromagnet 401 form periodic elastic force and tensile force, the liquid injection pipe 1 is driven to do periodic smooth motion, and the inertia force is formed to throw out liquid drops; the electromagnet 401 is controllable in current according to the time of generation of liquid drops, and the other permanent magnet 402 is connected with the liquid injection pipe 1, and the liquid injection pipe 1 is periodically moved towards or away from the electromagnet 401 under the periodic attraction force or pushing force of the electromagnet 401.

As shown in FIG. 2, FIG. 3 and FIG. 5, the spring return system 5 comprises at least two return springs 501, the two return springs 501 are respectively located at two sides of the electromagnetic drive system 4, and two ends of the return springs 501 are respectively connected with the top plate 3 and the liquid injection pipe 1. Specifically, because the liquid pouring spout 1 is vertically disposed, two return springs 501 are disposed on the upper and lower sides of the electromagnetic drive system 4, so that the entire liquid pouring spout 1 can move synchronously and stably. When the electromagnetic driving system 4 is electrified and contracted, the return spring 501 is compressed to accumulate potential energy, and the liquid injection pipe 1 moves towards the top plate 3; when the electromagnetic driving system 4 is powered off and expands, the return spring 501 releases potential energy to move the liquid injection pipe 1 away from the top plate 3, so that the inertia force for generating liquid drops is obtained.

As shown in fig. 8, it should be noted that, in order to avoid the situation that the return spring 501 repeatedly bounces during operation, the voltage of the electromagnet 401 changes as shown in fig. 8, but the polarity of the permanent magnet 402 does not change, and after the droplet generation effect is completed, the voltage of the electromagnet 401 rapidly changes direction, so that the acceleration direction changes, and the failure of droplet preparation caused by the repeated oscillation of the return spring 501 is avoided; that is, the initial state of the electromagnetic drive system 4 is the attraction state, the return spring 501 is the compression state, the N, S pole of the electromagnet 401 is changed according to the generation process of the micro-droplets 10, thereby controlling the compression and the bounce of the return spring 501, and avoiding the inertia effect of the liquid injection tube 1 caused by the repetition of the spring through the electrode conversion of the electromagnet 401.

As shown in fig. 17 and 18, it should be noted that in this embodiment 7, the spring return system 5 may be replaced by a retractable loop bar, so as to avoid the influence of the large current caused by the strong spring after the liquid drops are generated by the attraction and repulsion actions of the electromagnet 401 and the permanent magnet 402. Preparation failure due to too strong spring stiffness can also be avoided. The telescopic sleeves 6 are kept lubricated, and each sleeve is in a circular truncated cone shape with a small head and a large tail, so that the phenomenon that the sleeve is sheathed out due to misoperation of the electromagnet 401 and the device is damaged is avoided.

Example 3

Example 3 the collection dish 2 is further described:

as shown in fig. 1 and 2, the collection container 2 includes a transition box 201 and a drawer box 202, the transition box 201 is located below the liquid injection pipe 1 and is provided with a collection port 701, and the drawer box 202 is movably disposed at the bottom of the transition box 201. Specifically, drawer box 202 is located transition case 201 bottom and communicates with transition case 201 is inside, and the liquid drop is produced the back, because the influence of gravity, can sink into at the bottom of transition case 201, takes drawer box 202 out and can collect the liquid drop. One side of the transition box 201 is also provided with a liquid drainage pipe 203 which is communicated with the inside of the transition box 201 and used for draining a part of the liquid drops collected in the transition box 201 when the liquid drops are too much and then taking the drawer box 202 to avoid spilling the liquid drops.

As shown in fig. 4, 5 and 7, the top of the transition box 201 is provided with a box cover 7, the collection port 701 is positioned on the box cover 7, a sliding groove 702 is arranged on one side of the box cover 7 positioned at the collection port 701, a sliding rod 8 is connected to one side of the liquid injection pipe 1, and the sliding rod 8 is slidably inserted in the sliding groove 702. Specifically, the bottom of slide bar 8 is equipped with pulley 801, and pulley 801 rolls in embedding spout 702, does benefit to the production of inertial force, and because annotate liquid pipe 1 and pass through slide bar 8 and move along spout 702, has further reduced and has annotated liquid pipe 1 and vibrate the direction deviation that causes along with reset spring 501 repeatedly, makes the liquid droplet get into collection mouth 701 more easily, and the length of spout 702 is designed (generally is greater than reset spring 501 maximum extension length) according to reset spring 501 limit extension length, does benefit to electromagnet 401 and normally works.

Example 4

Example 4 describes the preparation of a double emulsion 11 by means of the present apparatus:

as shown in FIG. 5, FIG. 11-FIG. 16, the pouring spout 1 comprises an internal phase inlet spout 101 and an external phase inlet spout 102, and the external phase inlet spout 102 is spirally wrapped around the internal phase inlet spout 101. Specifically, the fluid in the external phase input pipe 102 wraps the fluid in the internal phase input pipe 101 along the wall of the spiral pipe to form an annular flow of the internal and external phases, and the fluid at the position of the micro-droplet outlet 104 of the liquid injection pipe 1 has an internal layer and an external layer, so that when the fluid is "thrown" into droplets, the fluid has an internal and external two-layer structure, and the fluid becomes the double emulsion 11. The inner side of the pipe wall of the external phase input pipe 102 is communicated with the outer side of the pipe wall of the internal input pipe and is spirally wound, the liquid inlet 103 of the internal input pipe is positioned at the top end of the liquid injection pipe 1, and the liquid inlet 103 of the external phase input pipe 102 is positioned at one side of the liquid injection pipe 1. Two input tubes are used when 11 drops of double emulsion are required to be generated; only the internal phase input line 101 is used when it is desired to generate single emulsion droplets.

Example 5

Example 5 further describes the top plate 3:

as shown in FIGS. 1 to 5, the top plate 3 comprises a fixed plate 301 and a positioning plate 302, the positioning plate 302 is slidably disposed on the fixed plate 301 on the side close to the pouring spout 1, and the linear reciprocating drive device is connected to the positioning plate 302. Specifically, the positioning plate 302 can slide up and down on the fixing plate 301 to adjust the height of the injection tube 1, so that the micro-droplet outlet 104 of the injection tube 1 is positioned above the surface of the collected liquid in the collection dish 2 and cannot be poured into the liquid surface; of course, the positioning plate 302 can also slide left and right to adjust the micro-droplet outlet 104 of the liquid injection tube 1 to align with the collection port 701 below.

As shown in FIGS. 2 and 6, a positioning groove 303 is formed on the fixing plate 301 on the side close to the pouring spout 1, a positioning plate 302 is slidably disposed in the positioning groove 303, a lock nut 304 is disposed on the fixing plate 301 on the side away from the pouring spout 1, and the lock nut 304 penetrates the fixing plate 301 and is locked to the positioning plate 302. Specifically, the positioning groove 303 and the positioning plate 302 are both in a T-shaped structure with matched sizes, the positioning plate 302 is embedded into the fixing plate 301 through the positioning groove 303 and slides up and down, and due to the clamping of the T-shaped structure, the locking nut 304 can tightly press the positioning plate 302 into the positioning groove 303 to realize locking and fixing.

Example 6

This example 6 describes the tilt movement of the pouring spout 1;

as shown in fig. 6, 13-16, the bottom end of the top plate 3 is connected to the collection dish 2 by a hinge mechanism 9. Specifically, the hinge mechanism 9 may be a bolt and a nut, a damping rotating shaft, etc. to connect the top plate 3 with the collection dish 2 and allow the top plate 3 to rotate at a certain angle relative to the collection dish 2, and due to the rotation of the top plate 3, the injection tube 1 also rotates correspondingly to incline the injection tube 1 to prepare the micro-droplets 10 in an inclined state. In the state that the top plate 3 is inclined by rotation, the return spring 501 is a spring with strong rigidity and strong flexibility resistance, and can bear the gravity of the liquid filling pipe 1 to keep the liquid filling pipe parallel to the top plate 3. Even when the top plate 3 is placed horizontally, the return spring 501 selects a spring that can support the pouring spout 1 without tilting, and the pouring spout 1 is kept parallel to the top plate 3, so that the double emulsion 11 can be dropped in a horizontal state. In addition, in order to match the inclined state movement of the liquid injection pipe 1, the slide rod 8 can be designed to be a telescopic rod, and the joint of the slide rod 8 and the liquid injection pipe 1 is designed to be in rotary connection, namely, the slide rod 8 can still play a role in guiding when the liquid injection pipe 1 is changed from a vertical state to an inclined state.

The working principle of the invention is as follows:

firstly, injecting fluid into a liquid inlet 103 of a liquid injection pipe 1, then enabling the liquid injection pipe 1 to be close to or far from a top plate 3 through an electromagnet 401 with periodic current change on the top plate 3 and a permanent magnet 402 on the liquid injection pipe 1, determining the movement direction of the liquid injection pipe 1 through a return spring 501/a telescopic sleeve 6, realizing that the liquid injection pipe 1 is driven to do periodic smooth movement, forming inertia force, and throwing liquid drops at a micro-liquid drop outlet 104 of the liquid injection pipe 1; the droplets pass through the transition box 201 under the action of gravity and then enter the drawer box 202, and the prepared micro droplets 10 can be taken out by taking out the drawer box 202.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. The micro-droplet preparation device is characterized by comprising a liquid injection pipe, wherein a collection vessel is arranged below the liquid injection pipe, a top plate is arranged on one side of the liquid injection pipe, and the liquid injection pipe is connected with the top plate through a linear reciprocating driving device.

2. The micro-droplet production apparatus of claim 1, wherein the linear reciprocating drive comprises an electromagnetic drive system and a spring return system.

3. The micro-droplet preparation apparatus of claim 2, wherein the electromagnetic driving system comprises an electromagnet and a permanent magnet, the electromagnet is fixed on the top plate, and the permanent magnet is fixed on the liquid injection pipe.

4. The micro-droplet preparation apparatus according to claim 2, wherein the spring return system comprises at least two return springs, the two return springs are respectively located at two sides of the electromagnetic driving system, and two ends of the return springs are respectively connected with the top plate and the liquid injection pipe.

5. The micro-droplet preparation apparatus according to claim 1, wherein the collection vessel comprises a transition box and a drawer box, the transition box is located below the liquid injection pipe and is provided with a collection port, and the drawer box is movably arranged at the bottom of the transition box.

6. The micro-droplet preparation apparatus according to claim 5, wherein a cover is disposed on the top of the transition box, the collection port is disposed on the cover, a slide slot is disposed on one side of the cover, the slide slot is slidably inserted into the slide slot, and a slide rod is connected to one side of the liquid injection tube.

7. The microdroplet preparation device of claim 1, wherein the liquid injection tube comprises an internal phase input tube and an external phase input tube, and the external phase input tube is wrapped on the internal phase input tube in a spiral surrounding manner.

8. The micro-droplet preparation apparatus according to claim 1, wherein the top plate comprises a fixing plate and a positioning plate, the positioning plate is slidably disposed on a side of the fixing plate close to the liquid injection pipe, and the linear reciprocating driving device is connected to the positioning plate.

9. The apparatus according to claim 8, wherein a positioning groove is formed on a side of the fixing plate close to the injection tube, the positioning plate is slidably disposed in the positioning groove, and a locking nut is disposed on a side of the fixing plate away from the injection tube, the locking nut penetrating through the fixing plate and locking with the positioning plate.

10. The micro-droplet preparation apparatus of claim 1, wherein the bottom end of the top plate is connected to the collection dish by a hinge mechanism.