CN114452543B - Phototherapy irradiation device for promoting different types of wounds to heal - Google Patents

Phototherapy irradiation device for promoting different types of wounds to heal Download PDF

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CN114452543B
CN114452543B CN202210272996.6A CN202210272996A CN114452543B CN 114452543 B CN114452543 B CN 114452543B CN 202210272996 A CN202210272996 A CN 202210272996A CN 114452543 B CN114452543 B CN 114452543B
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light
shell
irradiation
power
wound
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CN114452543A (en
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阴慧娟
崔峰
杜庆喆
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Tianjin Kunwei Biomedical Technology Partnership Enterprise LP
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Institute of Biomedical Engineering of CAMS and PUMC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0624Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0616Skin treatment other than tanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0636Irradiating the whole body
    • A61N2005/064Irradiating the whole body in a vertical position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/065Light sources therefor
    • A61N2005/0651Diodes
    • A61N2005/0652Arrays of diodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662Visible light
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02BCLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
    • Y02B20/00Energy efficient lighting technologies, e.g. halogen lamps or gas discharge lamps
    • Y02B20/40Control techniques providing energy savings, e.g. smart controller or presence detection

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  • Engineering & Computer Science (AREA)
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  • Radiation-Therapy Devices (AREA)

Abstract

A phototherapy irradiation device to promote healing of different types of wounds includes an LED array, a carrier assembly, and a control assembly. The invention has the beneficial effects that: the irradiation device irradiates by adopting light with three wavelengths, LEDs of the device are arranged in a specific array, emergent light spots are uniform, blue light, red light and infrared light can be combined by different wavelengths, and different powers and irradiation times are set, so that the device is used for healing various wounds, has a good treatment effect, and achieves the purposes of improving the continuous state of inflammation and promoting the wound healing in the epithelial evolution process; the device comprises a bracket part, a bracket part and a control part, wherein the bracket part is divided into a handheld bracket and an adjustable bracket and is suitable for various application scenes; the device is small in size and high in safety, and can be used for hospital treatment and family nursing.

Description

Phototherapy irradiation device for promoting different types of wounds to heal
Technical Field
The invention relates to a phototherapy irradiation device, in particular to a phototherapy irradiation device for promoting different types of wounds to heal, and belongs to the technical field of medical instruments.
Background
Biological wound healing is a complex process including an acute inflammation phase, a cell proliferation phase and a repair phase 3 phases, each of which affect each other. The type of wound (e.g., surgical wound, contaminated wound, refractory wound), the extent of injury and the ability of tissue regeneration determine the manner in which the wound is repaired, the healing time and the size of the scar. The therapeutic principle should be timely sterilization to prevent re-injury and promote tissue regeneration.
According to research, factors influencing wound healing are divided into systemic factors and local factors, and the two factors have great influence on wound regeneration and repair.
Systemic factors: systemic factors include age, nutrition and disease. In age, adolescents have strong tissue regeneration capacity and rapid wound healing speed. The old people have weak tissue regeneration capability and slow healing, and have great relation with the aging of blood vessels and the reduction of blood supply of the old people. Nutritionally, there is a delay in granulation tissue and wound healing when protein, and especially sulfur-containing amino acids, are deficient. In the aspect of diseases, diabetes and other diseases cause a series of influences such as blood sugar rise and blood flow reduction, and wounds are difficult to heal.
Local factors: local factors include wound infection aspects, local blood circulation aspects. In wound infection, infection presents a major obstacle to wound repair, and many suppurative bacteria produce toxins and enzymes that can cause tissue necrosis and matrix or collagen fibril lysis. This not only aggravates the local tissue damage, but also hinders healing. When a wound is infected, the exudate is so large that it can increase the tension of the local wound, often causing the healing wound or the sutured wound to split open, or causing the infection to spread and aggravate the injury. On the one hand, it ensures the oxygen and nutrients required for tissue regeneration, and on the other hand, it also plays an important role in the absorption of necrotic substances and in the control of local infections. When local blood flow is well supplied, regeneration and repair are good, and conversely, when the lower limb blood vessel has atherosclerosis or varicose veins and causes local poor blood circulation, the wound is slowly healed.
A number of wound healing techniques have not been studied to date, and for the prior art:
(1) sterilizing and bandaging: disinfecting with iodine tincture or alcohol or purple water, and rubbing from inside to outside along the wound edge without applying iodine tincture or alcohol into the wound. If foreign matters exist in the wound, the wound should be carefully treated, is large and easy to take out and can be taken out; deep and small, difficult to remove, and not reluctant to remove, so as to avoid introducing bacteria into the wound or increasing bleeding. A piece of clean cloth is attached to a hard object to press the wound. If the wound is on the limbs, the wounded part is lifted to be higher than the heart, blood can be stopped slowly, and the wound is waited to be naturally healed after the dressing is completed.
The problems that exist are that: the healing speed of the wound by the disinfection and package method mainly depends on the autoimmunity, and the wound is very slow to heal for the old and the diabetic patients without external treatment intervention.
(2) Use of the dressing:
various modern dressings have been developed based on the theory of wet healing. The dressing is divided into dressing for assisting wound treatment (including debridement dressing and anti-infection dressing) and dressing for accelerating wound repair (including moisture retention, liquid seepage management dressing, growth promotion dressing, tissue engineering skin and the like), provides a comfortable environment, protects an ulcer surface, controls seepage and the like.
The problems that exist are that: at present, the traditional dressing and the novel dressing have advantages and disadvantages, the types of the existing dressings are various, various new materials are continuously made, the functions are increasingly improved, but the purposes of the dressing are different from those of the ideal dressing in the true sense, and the dressing has a certain difference and has poor treatment effect on chronic ulcers such as diabetic ulcers, pressure sores and the like.
(3) Negative pressure wound therapy: the medical foam embedded with the drainage tube covers the whole wound surface and is connected with a negative pressure machine through a sucking disc and a pipeline to realize negative pressure wound treatment, and the medical foam is non-invasive treatment. The wound surface is in a wet environment, the local blood flow is increased, the local edema is eliminated to a certain degree, the exudation is reduced, the microenvironment is improved, the deep cavity of the wound surface is reduced, the mechanical stress is changed, the cell proliferation is promoted, the angiogenesis and the granulation tissue hyperplasia are promoted, and the purposes of reducing the size of the wound and promoting the healing of the wound are achieved.
The problems that exist are that: there is currently insufficient evidence to support the benefits of negative pressure wound therapy as an adjuvant healing measure to control bioburden.
(4) Phototherapy equipment: at present, near-infrared therapeutic instruments are adopted in phototherapy instruments for treating diabetic feet on the market, flexible therapeutic pieces are selected for the therapeutic instruments, and light sources are arranged in the therapeutic pieces to irradiate the wounds of patients. The instrument adopts a specific single-wavelength infrared ray light energy treatment system, the specific wavelength is generally 890nm +/-10 nm, the penetrating power can reach subcutaneous 5cm, the near infrared ray therapeutic apparatus is used as a simple, high-efficiency and easy-to-use rehabilitation treatment device, no wound and no side effect exist, and the autoimmune rehabilitation system is excited by improving local blood circulation of the near infrared ray therapeutic apparatus.
The problems that exist are as follows: the phototherapy instruments on the market mostly adopt single near infrared wavelength therapy, only pay attention to penetration depth, but neglect specific absorption of different biological tissues to light in the wound healing process, do not consider the absorption wavelength range of different photoreceptors, and cause that the treatment effect is unstable and not significant. Meanwhile, the spot range, the positioning, the usability and the like of the phototherapy instrument have large differences. .
Disclosure of Invention
The present invention is directed to solving the above problems by providing a phototherapy irradiation device that promotes healing of different types of wounds.
The invention realizes the purpose through the following technical scheme: a phototherapy irradiation device for promoting healing of different types of wounds comprises
The LED array is a packaged LED light source capable of emitting three wavelengths, the LED array arrangement interval which can uniformly emit light on a target irradiation surface is calculated according to the LED light beam distribution characteristics, the LED array arrangement interval forms a uniform light emitting array, and the LED array comprises LED array circuit boards which respectively control the three wavelengths to emit light;
the carrier assembly forms a main body supporting structure of the irradiation device and consists of a loading assembly and a support assembly, wherein the loading assembly comprises a shell and a light-transmitting sheet fixedly arranged at the front end of the shell, and the bottom end of the side edge of the shell is provided with a universal mounting hole connected with the support assembly; the bracket assembly includes: the universal triangular support of the hand-held support or the adjustable support is connected with the universal mounting hole on the shell;
the control assembly is used for controlling the irradiation device to work and comprises a control circuit board loading assembly arranged in the shell, a control interface loading assembly arranged on a control panel at the tail end of the shell and a liquid crystal display screen, the control circuit board loading assembly comprises a single chip microcomputer, a voltage reduction and voltage stabilization circuit, a high-power LED driving circuit and a capacitor resistor, the single chip microcomputer is in MM32F103KET type and performs signal transmission with the liquid crystal display screen, the control interface loading assembly comprises a setting key and a start/pause button which are positioned below the liquid crystal display screen and a program selection button which is positioned below the setting key, the single chip microcomputer is in signal transmission connection with the control interface loading assembly, a power supply port which is electrically connected with external 220V alternating current through a power supply adapter is arranged on the control panel at the tail end of the shell, and one power supply of the power supply port is electrically connected with the single chip through the voltage reduction and voltage stabilization circuit, and the other power supply of the power supply port is electrically connected with the LED array circuit board through the high-power LED driving circuit.
As a still further scheme of the invention: the LED array circuit board is positioned on the inner side of the light transmitting sheet at the front end of the shell, LED light sources of LED bare chips with three wavelengths, namely blue light (the range of 400-500nm), red light (the range of 600-700nm) and infrared light (the range of 800-900nm), which are arranged in parallel are arranged and packaged on the LED array circuit board according to an array form, and a corresponding resistance resistor is placed on each wavelength LED circuit to adjust the input voltage and the current of the LEDs with the three wavelengths to be similar.
As a still further scheme of the invention: the bracket component is detachably connected with the universal mounting hole through a threaded link.
As a still further scheme of the invention: the light transmission sheet is a high-transparency optical lens sheet.
As a still further scheme of the invention: and the tail end control panel of the shell is also provided with a startup and shutdown key.
As a still further scheme of the invention: after the setting key is clicked, setting irradiation treatment parameters through a blue light power adjusting button, a red light power adjusting button, an infrared light power adjusting button and a time setting button which are arranged on a control panel at the tail end of the shell, wherein the power adjusting button is a microswitch, the power is adjusted up by 5mW (milliwatt) for 1 time at each point, the adjustment is totally 3 steps, the range is 5-15mW, and the range can be adjusted by changing a resistor assembly on a control circuit; the time is set to the micro switch of the button, and the time is increased by 1min and ranges from 0min to 30min after the micro switch is pressed for 1 time per point.
As a still further scheme of the invention: after the program selection button is clicked, program selection or setting is carried out through a program A, a program B or a program C arranged on a control panel at the tail end of the shell, wherein the programs A-C can be composed of fixed parameters of different types of wound irradiation treatment, the program A can be set as an operation wound irradiation treatment scheme, the red light power is set to be 5mW, the infrared light power is set to be 5mW, and the irradiation time is set to be 10 min; the program B can be set as a contaminated wound irradiation treatment scheme, the blue light power is 10mW, the red light power is 10mW, and the irradiation time is 20 min; the program C can be set as a diabetic foot irradiation treatment scheme, wherein the red light power is 15mW, the infrared light power is 15mW, and the irradiation time is 10 min. These programs can be set by the physician's own experience in the clinic, and can be factory set according to the treatment recommendations of literature.
The invention has the beneficial effects that:
1. the LEDs of the device are arranged in a specific array, the emergent light spots are uniform, and the blue light, the red light and the infrared light can be used for healing various types of wounds through the combination of different wavelengths and the setting of different powers and irradiation times;
2. the device has small volume, can be used for hospitals and family nursing;
3. the device support part is divided into a handheld support and an adjustable support, is flexible to use and is suitable for various application scenes.
Drawings
FIG. 1 is a schematic view of a treatment regimen of the present invention;
FIG. 2 is a schematic diagram of the front end structure of the present invention;
FIG. 3 is a schematic view of the tail end structure of the present invention;
FIG. 4 is a schematic view of the rear end of the present invention;
FIG. 5 is a schematic diagram of a three-wavelength LED array arrangement according to the present invention;
FIG. 6 is a schematic diagram of an LED array distribution circuit of the present invention;
FIG. 7 is a schematic diagram of a control circuit according to the present invention;
FIG. 8 is a schematic view of a third embodiment of the present invention;
FIG. 9 is a graph showing the effect of the four wound healing phototherapy devices of the present invention on wound cleaning in mice;
FIG. 10 is a graph showing the effects of a four-wound healing phototherapy device according to an embodiment of the present invention on the treatment of infected wounds in mice;
fig. 11 shows the effect of the four wound healing phototherapy devices of the present invention on the treatment of diabetic wounds in mice.
In the figure: 1. the LED lamp comprises a light-transmitting sheet, 2, an LED array circuit board, 3, a shell, 4, a universal mounting hole, 5, a liquid crystal display screen, 6, a startup and shutdown key, 7, a setting key, 8, a blue light power adjusting key, 9, a red light power adjusting button, 10, an infrared light power adjusting button, 11, a time setting button, 12, a start/pause button, 13, a program selecting button, 14, programs A and 15, programs B and 16, programs C and 17 and a power supply port.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example one
Referring to fig. 1-8, a phototherapy irradiation device for promoting healing of different types of wounds comprises
The LED array is a packaged LED light source capable of emitting three wavelengths, an even light emitting array is formed at a specific interval (according to the light beam distribution characteristics of a single LED, the arrangement interval of the LED array is calculated to be 2cm on an irradiation surface at a specific distance, and under the condition of even irradiation, each LED is spaced by 2cm and is in square distribution), the LED array comprises LED array circuit boards 2 for respectively controlling the three wavelengths to emit light, and the LED array circuit boards are combined by adjusting the respective optical power densities of the three wavelengths to achieve the purpose of treating wounds such as clean wounds, pollution wounds and wounds which are difficult to heal;
the carrier assembly forms a main body supporting structure of the irradiation device and consists of a loading assembly and a support assembly, wherein the loading assembly comprises a shell 3 and a light-transmitting sheet 1 fixedly arranged at the front end of the shell 3, and the bottom end of the side edge of the shell 3 is provided with a universal mounting hole 4 connected with the support assembly; the bracket assembly includes: the universal triangular support of the hand-held support or the adjustable support is connected with the universal mounting hole on the shell;
a control assembly for controlling the irradiation device to work, and comprising a control circuit board loading assembly arranged in the shell 3, a control interface loading assembly and a liquid crystal display 5, wherein the control circuit board loading assembly mainly comprises a single chip microcomputer such as MM32F103KET, a voltage reduction and voltage stabilization circuit, a high-power LED drive circuit, a capacitance resistor and other elements, the control interface loading assembly is arranged on a control panel at the tail end of the shell 3, the control circuit board loading assembly comprises a single chip microcomputer with MM32F103KET, a voltage reduction and voltage stabilization circuit, a high-power LED drive circuit and a capacitance resistor which are in signal transmission with the liquid crystal display 5, the control interface loading assembly comprises a setting key 7 and a start/pause button 12 which are positioned below the liquid crystal display 5, and a program selection button 13 which is positioned below the setting key 7, the single chip microcomputer is in signal transmission connection with the control interface loading assembly, and the control panel at the tail end of the shell 3 is provided with a power adapter which is electrically connected with 220V alternating current through the power adapter The power supply port 17, one power supply of the power supply port 17 is electrically connected with the single chip through the voltage reduction and stabilization circuit, and the other power supply of the power supply port 17 is electrically connected with the LED array circuit board 2 through the high-power LED driving circuit.
In the embodiment of the invention, the LED array circuit board 2 is located inside the light-transmitting sheet 1 at the front end of the housing 3, and the LED array circuit board 2 is packaged with blue light (range 400-; the LED light source with the bare LED dies with three wavelengths is characterized in that a corresponding resistance resistor is arranged on each wavelength LED circuit to adjust the input voltage and current of the LEDs with the three wavelengths to be similar, 400-wavelength light and 500-nm wavelength light mainly play a role in diminishing inflammation and sterilizing in the process of promoting wound healing, 600-wavelength light and 700-nm wavelength light play a role in repairing cells and promoting blood circulation in the process of promoting wound healing, and 800-wavelength light and 900-nm wavelength light play a role in easing pain in the process of promoting wound healing.
In the embodiment of the invention, the bracket component is detachably connected with the universal mounting hole 4 through the threaded connection, and the bracket component adopts two designs of a handheld bracket and an adjustable bracket, so that the portability of the device is improved, and different irradiation requirements are met.
In the embodiment of the invention, the light transmission sheet 1 is a high-transparency optical lens sheet, so that the distance between the LED array and the skin is kept, meanwhile, the interior of the machine is free of dust, the LED array is protected, and the reliability of the device is improved.
Example two
Referring to fig. 1-8, a phototherapy irradiation device for promoting healing of different types of wounds comprises
A control assembly for controlling the irradiation device to work, and comprising a control circuit board loading assembly arranged in the shell 3, a control interface loading assembly and a liquid crystal display 5, wherein the control circuit board loading assembly mainly comprises a single chip microcomputer such as a model MM32F103KET, a voltage reduction and voltage stabilization circuit, a high-power LED drive circuit and a capacitance resistance element, the control interface loading assembly is arranged on a control panel at the tail end of the shell 3, the control circuit board loading assembly comprises the single chip microcomputer with the model MM32F103KET, the voltage reduction and voltage stabilization circuit, the high-power LED drive circuit and the capacitance resistance which are in signal transmission with the liquid crystal display 5, the control interface loading assembly comprises a setting key 7 and a start/pause button 12 which are positioned below the liquid crystal display 5, and a program selection button 13 which is positioned below the setting key 7, the single chip microcomputer is in signal transmission connection with the control interface loading assembly, and the control panel at the tail end of the shell 3 is provided with a control panel which is electrically connected with a 220V alternating current through a power adapter And one power supply of the power supply port 17 is electrically connected with the single chip through a voltage reduction and stabilizing circuit, and the other power supply of the power supply port 17 is electrically connected with the LED array circuit board 2 through a high-power LED driving circuit.
In the embodiment of the invention, a switch-on/off key 6 is further arranged on the control panel at the tail end of the shell 3, and is a main switch key of the device, the device is powered on after being pressed down, an interface screen is bright, and the operation of setting parameters can be started.
In the embodiment of the present invention, after the setting key 7 is clicked, irradiation treatment parameters are set through a blue light power adjusting button 8, a red light power adjusting button 9, an infrared light power adjusting button 10 and a time setting button 11 which are arranged on a control panel at the tail end of the housing 3, wherein the power adjusting button is a micro switch, and the power is adjusted up by 5mW after 1 click, which is a total of 3 steps of adjustment, and the range is 5-15mW, and the range can be adjusted by changing a resistor component on a control circuit; the time setting button 11 is a microswitch, and the time is increased by 1min and ranges from 0min to 30min after the time is pressed for 1 time per point.
After the program selection button 13 is clicked, program selection or setting is carried out through a program A14, a program B15 or a program C16 arranged on a control panel at the tail end of the shell 3, wherein the programs A-C can be composed of fixed parameters of different types of wound irradiation treatment, the program A14 can be set as an operation wound irradiation treatment scheme, the red light power is set to be 5mW, the infrared light power is set to be 5mW, and the irradiation time is set to be 10 min; the program B15 can be set as a contaminated wound irradiation treatment scheme, wherein the blue light power is 10mW, the red light power is 10mW, and the irradiation time is 20 min; the program C16 can be set as the diabetes foot irradiation treatment scheme, and the red light power is 15mW, the infrared light power is 15mW, and the irradiation time is 10 min. These programs can be set by the physician's own experience in the clinic, and can be factory set according to the treatment recommendations of literature.
EXAMPLE III
Referring to fig. 8, a phototherapy irradiation device for promoting healing of different types of wounds includes a fixed procedure treatment operation procedure
Determining the type of the wound of the patient → clicking a switch key, starting the device → clicking a set key, setting the treatment time → clicking a program selection button → clicking a program ABC button → clicking a start button → performing the irradiation treatment → timing is completed → completing the treatment → turning off.
Example four
Referring to fig. 9 to 11, a phototherapy irradiation device for promoting different types of wounds to heal is provided to treat different types of wounds of a mouse, and experimental data thereof includes:
(1) wound cleansing effect
A clean wound model was prepared using BALB/c mice (9-10 weeks old, male, about 25g), and a 1cm thick skin was prepared by cutting the entire skin at the middle and lower back with surgical scissors 2 The wound of (1). Treating mouse wound with 3-wavelength wound healing device with different power densities (5-15 mW/cm) 2 ) The irradiation time is 10min, the treatment is carried out for 1 time every day for 14 days continuously, the wound healing speed of the light treatment experimental group is obviously higher than that of the control group, and the wound is basically healed by 14 days.
(2) Wound infection effect
A BALB/c mouse (9-10 weeks old, male, about 25g) was used to prepare an infected wound model, and a surgical scissors was used to cut the whole skin at the middle and lower back to prepare a 1cm skin 2 The wound of (1). 100ul of staphylococcus aureus and verdigris are dripped on the woundPseudomonas bacteria 1: 1 mixed concentration of 5X 10 7 And (5) preparing CFU/mL mixed bacterial liquid, and obtaining the wound after 72 h. The wound of the mouse is treated by adopting a 3-wavelength wound healing treatment device which is divided into different power densities (5-15 mW/cm) 2 ) The irradiation time is 20min, the treatment is carried out for 1 time every day for 14 consecutive days, the wound healing speed of the light treatment experimental group is obviously higher than that of the control group, the effect is equivalent to that of the antibiotic group, and the wound is basically healed by fourteen days.
(3) Wound healing effect of diabetes
Preparing a diabetic wound model by using BALB/c mice (9-10 weeks old, male, 25g), carrying out intraperitoneal injection on the BALB/c mice after fasting and water prohibition for 12h, carrying out intraperitoneal injection on the BALB/c mice for 1 time by using an STZ (the STZ is prepared in 0.1mol/L sodium citrate buffer solution with the concentration of 1% and the pH value of 4.5) at a dose of 150mg/kg body weight, taking blood after 1 week to measure blood sugar, judging the mice as the diabetic mice when the blood sugar is higher than 16.5mmol/L, and preparing a1 cm-thick skin on the middle lower part of the back by using surgical scissors to cut off the whole skin on the middle lower part of the back 2 The wound of (1). Treating mouse wound with 3-wavelength wound healing device with different power densities (5-15 mW/cm) 2 ) The irradiation time is 10min, the treatment is carried out for 1 time every day for 14 days continuously, the wound healing speed of the light treatment experimental group is obviously higher than that of the control group, and the wound is basically healed by 14 days.
The working principle is as follows: the low-energy LED light with the wavelength ranges of 400-500nm, 600-700nm and 800-900nm is adopted to carry out combined irradiation with different wavelengths and different powers, so as to achieve the purpose of promoting wound healing by eliminating wound inflammation, relieving pain and promoting cell proliferation.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (4)

1. A phototherapy irradiation device for promoting healing of different types of wounds, characterized by: comprises that
The LED array is a packaged LED light source capable of emitting three wavelengths, the LED array arrangement interval which can uniformly emit light on a target irradiation surface is calculated according to the LED light beam distribution characteristics, the LED array arrangement interval forms a uniform light emitting array, and the LED array comprises LED array circuit boards (2) which respectively control the three wavelengths to emit light;
the carrier assembly forms a main body supporting structure of the irradiation device and consists of a loading assembly and a support assembly, the loading assembly comprises a shell (3) and a light-transmitting sheet (1) fixedly installed at the front end of the shell (3), and the bottom end of the side edge of the shell (3) is provided with a universal installation hole (4) connected with the support assembly; the bracket assembly includes: the handheld bracket or the adjustable bracket is connected with the universal mounting hole on the shell (3);
the control assembly is used for controlling the irradiation device to work and comprises a control circuit board loading assembly arranged in the shell (3), a control interface loading assembly arranged on a control panel at the tail end of the shell (3) and a liquid crystal display (5), the control circuit board loading assembly comprises a single chip microcomputer, a voltage reduction and voltage stabilization circuit, a high-power LED driving circuit and a capacitance resistor, the single chip microcomputer is in signal transmission connection with the control interface loading assembly, the control interface loading assembly comprises a setting key (7) and a start/pause button (12) which are positioned below the liquid crystal display (5) and a program selection button (13) which is positioned below the setting key (7), the control panel at the tail end of the shell (3) is provided with a power supply port (17) which is electrically connected with the external 220V alternating current through a power supply adapter, one power supply of the power supply port (17) is electrically connected with the single chip through a voltage reduction and stabilization circuit, and the other power supply of the power supply port (17) is electrically connected with the LED array circuit board (2) through a high-power LED driving circuit;
the LED array circuit board (2) is positioned on the inner side of the light transmitting sheet (1) at the front end of the shell (3), and the LED array circuit board (2) is packaged with blue light arranged in parallel according to an array form, wherein the range is 400-500 nm; red light in the range of 600-700 nm; infrared light, range 800-; LED light sources of LED bare chips with three wavelengths, and a corresponding resistance resistor is arranged on each wavelength LED circuit to adjust the input voltage and current of the LEDs with the three wavelengths to be similar;
after the setting key (7) is clicked, setting irradiation treatment parameters through a blue light power adjusting button (8), a red light power adjusting button (9), an infrared light power adjusting button (10) and a time setting button (11) which are arranged on a control panel at the tail end of the shell (3), wherein the power adjusting button is a microswitch, the power is adjusted up by 5mW (milliwatt) 1 time at each point, the adjustment is carried out in 3 steps totally, the range is 5-15mW, and the range can be adjusted by changing a resistor assembly on a control circuit; a time setting button (11) is a microswitch, and the time is increased by 1min in a range of 0-30min after the microswitch is pressed for 1 time per point;
after the program selection button (13) is clicked, program selection or setting is carried out through a program A (14), a program B (15) or a program C (16) which are arranged on a control panel at the tail end of the shell (3), wherein the programs A-C are composed of fixed parameters of different types of wound irradiation treatment, the program A (14) is set to be an operation wound irradiation treatment scheme, the red light power is set to be 5mW, the infrared light power is set to be 5mW, and the irradiation time is set to be 10 min; program B (15) is set as a contaminated wound irradiation treatment scheme, and blue light power is set to be 10mW, red light power is set to be 10mW, and irradiation time is set to be 20 min; the program C (16) is set as a diabetic foot irradiation treatment scheme, the red light power is 15mW, the infrared light power is 15mW, and the irradiation time is 10 min.
2. A phototherapy irradiation device as defined in claim 1, wherein: the bracket component is detachably connected with the universal mounting hole (4) through a threaded link.
3. A phototherapy irradiation device as defined in claim 1, wherein: the light transmitting sheet (1) is a high-transparency optical lens sheet.
4. A phototherapy irradiation device as defined in claim 1, wherein: and a startup and shutdown key (6) is further arranged on the tail end control panel of the shell (3).
CN202210272996.6A 2022-03-18 2022-03-18 Phototherapy irradiation device for promoting different types of wounds to heal Active CN114452543B (en)

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CN203139413U (en) * 2013-03-22 2013-08-21 北京德麦特捷康科技发展有限公司 Dermatopathy therapeutic instrument with combined light source
CN105498096A (en) * 2015-12-18 2016-04-20 金进科技(深圳)有限公司 Optical wound therapy apparatus
CN109966650A (en) * 2017-12-28 2019-07-05 广东百视特照明电器有限公司 A kind of Led treating herpes instrument and treatment method
CN110681062A (en) * 2019-09-28 2020-01-14 复旦大学 Auxiliary phototherapy equipment for bone defect repair
CN110681058A (en) * 2019-09-28 2020-01-14 复旦大学 Pulsed light phototherapy equipment
CN112972906A (en) * 2021-03-04 2021-06-18 湖北协进半导体科技有限公司 Multifunctional LED beauty and health lamp based on red, yellow and blue wavelength gain
CN113663225A (en) * 2021-07-27 2021-11-19 杭州大力神医疗器械有限公司 High-energy photon pulsation treatment system
CN113633896A (en) * 2021-09-14 2021-11-12 中国医学科学院生物医学工程研究所 Optical irradiation device and method for treating diabetic foot

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