CN114432163A - 膜和包含所述膜的口腔护理组合物 - Google Patents
膜和包含所述膜的口腔护理组合物 Download PDFInfo
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- CN114432163A CN114432163A CN202011200316.7A CN202011200316A CN114432163A CN 114432163 A CN114432163 A CN 114432163A CN 202011200316 A CN202011200316 A CN 202011200316A CN 114432163 A CN114432163 A CN 114432163A
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- oral care
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- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- 210000004885 white matter Anatomy 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
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- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229910052984 zinc sulfide Inorganic materials 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
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Abstract
膜和包含所述膜的口腔护理组合物。本发明涉及膜和包含所述膜的口腔护理组合物。本文中描述的是用于口腔护理组合物中的膜,其包含:二氧化硅;聚合物;天然树胶;以及折射率为约1.0至约2.5的颗粒;其中所述聚合物与多糖的重量比为约2∶1至约3∶1。
Description
技术领域
本发明涉及膜和包含所述膜的口腔护理组合物。
背景技术
已经承认美学效果在许多产品的消费者接受中发挥重要作用。在许多情况下,装饰效果已被用于区分市场上的特定产品并识别具有特定独特特性的产品。在洁牙剂(dentifrice)领域中,已知其中掺有对比(contrasting)的有色薄片(flake)的基本上透明的洁牙剂产品,例如牙膏和凝胶。这样的薄片提供了消费者感到满意并且促进洁牙剂的使用,特别是儿童的使用的美学效果。尽管这样的产品已经获得了消费者的认可,但是本领域试图进一步改善这些产品的美学效果以及美容和治疗益处,以鼓励在践行口腔卫生中使用洁牙剂。
此外,存在某些成分,已知这些成分在不损害洁牙剂中的膜的韧性和/或稳定性的情况下提供期望的不透明性。然而,已知提供这种益处的某些成分与不期望的影响相关。因此,仍然需要在不损害洁牙剂中的膜的韧性和/或稳定性的同时提供期望美感的另外的成分。设计本发明的某些实施方案以满足这些和其他目的。
发明内容
本发明的一些实施方案提供了用于口腔护理组合物中的柔性膜,其包含:二氧化硅;聚合物;天然树胶(natural gum);以及折射率为约1.0至约2.5的颗粒;其中聚合物与多糖的重量比为约2∶1至约3∶1。
本发明的另一些实施方案提供了一种口腔护理组合物,其包含:口腔可接受的载体;以及多个膜或膜片段,其中每个膜或膜片段包含:二氧化硅;折射率为约1.5至约2.0的颗粒;纤维素材料;以及多糖;其中纤维素材料和多糖以约2.5∶1的重量比存在;并且其中所述膜基本上不含含钛材料(titanium containing material)。
本发明的另一些实施方案提供了包含如本文中所述膜的口腔护理组合物。
又一些实施方案提供了使用本文中所述膜和组合物的方法。
具体实施方式
为了说明的目的,通过参考本发明的多个示例性实施方案描述了本发明的原理。尽管本文中具体描述了本发明的某些实施方案,但是本领域普通技术人员将容易认识到,相同的原理同样适用于其他装置和方法,并且可以在其他装置和方法中使用。在详细描述本发明的某些实施方案之前,应当理解,本发明在其应用方面不限于所示出的任何特定实施方案的细节。本文中使用的术语出于说明目的,而不是限制目的。
如本文和所附权利要求书中所使用的,除非上下文另有规定,否则没有数量词修饰的名词表示一个/种或更多个/种。任何成分类别的单数形式不仅指该类别中的一个化学物种,而且还指那些化学物种的混合物。术语“一个”(或“一种”)、“一个/种或更多个/种”和“至少一个/种”在本文中可以互换地使用。术语“包括”、“包含”和“具有”可以互换地使用。术语“包括”应解释为“包括但不限于”。术语“包含”应解释为“包含但不限于”。
当提及数字时,术语“约”意指在该数字的10%范围内的任何数字。例如,短语“约0.050wt%”是指介于0.04500wt%与0.05500wt%之间并且包括0.04500wt%和0.05500wt%的数字。
如自始至终所使用的,范围用作用于描述该范围内的每一个值和每个值的简写。范围内的任何值都可以被选择作为范围的端点。
术语“混合物”将被广义地解释。它是指成分的混合物。混合物可以是固体、液体、半固体。如果混合物是液体,则混合物可以是溶液、乳液、分散体、显示丁达尔效应的混合物或任何其他均匀混合物。在一个实施方案下,混合物是贮存稳定的。当提及成分列表时,除非另外特别指出,否则术语“混合物”是指上述成分彼此的混合物、任何上述成分与上面未提及的其他成分的混合物以及几种上述成分与上面未提及的其他成分的混合物。例如,短语“氟化物源选自氟化亚锡(stannous fluoride)、氟化钠、氟化胺、单氟磷酸钠及其混合物”中的术语“混合物”是指以下中的任一种:氟化亚锡和氟化钠的混合物;或氟化亚锡和氟化胺的混合物;或氟化亚锡和单氟磷酸钠的混合物;或氟化钠和氟化胺的混合物;或氟化钠和单氟磷酸钠的混合物;或氟化胺、单氟磷酸钠的混合物;或氟化亚锡和任何其他氟化物源的混合物;或氟化钠和任何其他氟化物源的混合物;或氟化胺和任何其他氟化物源的混合物;或单氟磷酸钠和任何其他氟化物源的混合物;以及其其他组合。
用于例举或定义属(genus)的物种(species)列表中的任何成员可以与物种列表中的任何其他成员互不相同,或与其重叠,或是其子集,或与其等同,或与其几乎相同,或与其相同。此外,除非明确说明,否则例如当叙述马库什群组时,定义或例举属的物种列表是开放式的,并且给出可以存在定义或例举该属的与列出的任何其他物种一样好或比列出的任何其他物种更好的其他物种。
本文中引用的所有参考文献均在此通过引用整体并入。在本公开内容中的定义与所引用的参考文献的定义冲突的情况下,以本公开内容为准。
当用于描述本发明时,术语“基本上透明的”应当意指半透明或透明的。术语“洁牙剂”应包括牙膏和凝胶。
在一些实施方案中,本文中所述膜可以包含折射率为约1.5至2的颗粒物质;以及纤维素材料(例如HPMC)和淀粉,其中纤维素材料∶淀粉的重量比为约2.5∶1。在一些实施方案中,膜还可以包含着色剂(colorant)例如染料(dye)或颜料(pigment)、香料(flavorant)、甜味剂和/或治疗剂例如抗菌剂(antibacterial agent)或口气清新剂(breath freshening agent)。
膜厚度的大小为0.5至10微米,并且优选2至3微米。然后将本发明的干燥的膜切割或冲压成颗粒尺寸为0.01至0.50英寸,优选0.08至0.25英寸的成形薄片。
在一些实施方案中,口腔护理组合物还包含抗恶臭剂。在一些实施方案中,额外的抗恶臭化合物是已知的气味控制剂。此外,其他含金属的化合物,例如铜、亚锡(stannous)、铋、锶的含金属的化合物,以及增强唾液流动、起到洗去气味作用的肉质植物(succulent)或其他成分可用于本文中所述组合物中。截留或吸附恶臭分子的某些强的基于柑橘的香料、气味吸收复合物也可用于要求保护的组合物中。例如,如例如美国专利第6,664,254号中公开的,具有将恶臭分子(例如硫醇、硫化物和胺)包封在其结构内的能力。合适的气味控制活性物还包括但不限于可以中断产生气味的过程的酶。例如,气味阻断酶例如精氨酸脱亚氨酶可以有效地配制在本发明的组合物中。另外,有效抑制恶臭分子的细菌产生的分子可以用于控制气味,例如干扰细菌酶半胱氨酸脱巯基酶和/或蛋氨酸γ-裂解酶的试剂。适用于气味阻断或作为气味阻断剂的气味控制活性物包括但不限于通过氧化或以其他方式与恶臭分子发生化学反应而起作用的试剂,包括过氧化物、高氯酸盐和具有活化双键的反应性分子。
在一些实施方案中,本发明的口腔护理组合物包含载体。载体可以包括但不限于水或其他水性溶剂体系。在一些实施方案中,载体是口腔可接受的载体。在一些实施方案中,口腔可接受的载体还可以包含保湿剂。可能的保润剂是乙醇;多元醇,其包括但不限于甘油、乙二醇、肌醇、麦芽糖醇、甘露糖醇、山梨糖醇、木糖醇、丙二醇、聚丙二醇(PPG)、聚乙二醇(PEG)及其混合物;或糖类,包括但不限于果糖、葡萄糖、蔗糖和糖类的混合物(例如蜂蜜)。
在另一些实施方案中,口腔护理组合物还可以包含抗菌剂。在另一些实施方案中,抗菌剂选自:三氯生(5-氯-2-(2,4-二氯苯氧基)苯酚);8-羟基喹啉及其盐;锌或亚锡离子源,例如柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸钠锌、氟化亚锡、单氟磷酸亚锡和焦磷酸亚锡;铜(II)化合物,例如铜(II)的氯化物、氟化物、硫酸盐和氢氧化物;邻苯二甲酸及其盐,例如邻苯二甲酸单钾镁;血根碱(sanguinarine);季铵化合物,例如烷基吡啶氯化物(例如十六烷基吡啶氯化物(CPC)、CPC与锌和/或酶的组合、十四烷基吡啶氯化物和N-十四烷基-4-乙基吡啶氯化物);双胍类,例如氯己定二葡糖酸盐、海克替啶、奥替尼啶、阿来西定;卤化双酚化合物,例如2,2’亚甲基双-(4-氯-6-溴酚);苯扎氯铵;水杨酰苯胺、溴化度米芬;碘;磺胺类;双双胍类(bisbiguanide);酚类;哌啶衍生物,例如地莫匹醇和辛哌醇;木兰提取物;麝香草酚;丁香酚;薄荷醇;香叶醇;香芹酚;柠檬醛;桉树脑;儿茶酚;4-烯丙基儿茶酚;己基雷琐酚;水杨酸甲酯;抗生素,例如奥格门汀(augmentin)、阿莫西林、四环素、多西环素、米诺环素、甲硝唑、新霉素、卡那霉素和克林霉素;或其混合物。
在一些实施方案中,抗菌剂以按重量计约0.001%至约3%、按重量计约0.05%至约2%或按重量计约0.075%至约1.5%的浓度存在。
在一些实施方案中,口腔护理组合物还可以包含防龋剂、脱敏剂、黏度调节剂、稀释剂、表面活性剂、乳化剂、泡沫调节剂、pH调节剂、研磨剂(abrasive)、口感剂、甜味剂、调味剂、着色剂、防腐剂、氨基酸、抗氧化剂、抗牙垢剂(anti-calulus agent)、氟离子源、增稠剂、用于预防或治疗口腔的硬组织或软组织的病症或障碍的活性剂、黏合剂、增白剂及其组合。应当理解,虽然以上材料类别中的每一种的一般属性可以不同,但是可以存在一些共同的属性,并且任何给定的材料可以在两种或更多种这样的材料类别中用于多种目的。优选地,选择载体以与组合物的其他成分相容。
本发明的一些实施方案任选地包含氨基酸。合适的氨基酸包括但不限于精氨酸、半胱氨酸、亮氨酸、异亮氨酸、赖氨酸、丙氨酸、天冬酰胺、天冬氨酸盐/酯、苯丙氨酸、谷氨酸盐/酯、谷氨酸、苏氨酸、谷氨酰胺、色氨酸、甘氨酸、缬氨酸、脯氨酸(praline)、丝氨酸、酪氨酸、和组氨酸以及其两种或更多种的组合。氨基酸可以包括R和L形式及其盐形式。氨基酸(及其盐形式)还可以包括氨基酸的酸酯和/或脂肪酰胺衍生物(例如月桂酰精氨酸乙酯盐酸盐(ELAH))。
本发明的又一些实施方案提供了包含抗氧化剂的口腔护理组合物。可以使用任何口腔可接受的抗氧化剂,包括丁基化羟基茴香醚(BHA)、丁基化羟基甲苯(BHT)、维生素A、类胡萝卜素、维生素E、类黄酮、多酚、抗坏血酸、草本抗氧化剂、叶绿素、褪黑激素及其混合物。
本发明的另一些实施方案包括抗牙垢(牙垢控制)剂。合适的抗牙垢剂包括但不限于磷酸盐和多磷酸盐(例如焦磷酸盐)、聚氨基丙磺酸(AMPS)、六偏磷酸盐、柠檬酸锌三水合物、多肽、聚烯烃磺酸盐、聚烯烃磷酸盐、二膦酸盐。在一些实施方案中,抗牙垢剂以约0.1%至约30%的量存在。口腔组合物可以包含不同的抗牙垢剂的混合物。在一个优选的实施方案中,使用焦磷酸四钠(TSPP)和三聚磷酸钠(STPP)。在一些实施方案中,抗牙垢剂包含按重量计约0.1%至约5%的TSPP。在另一些实施方案中,抗牙垢剂包含按重量计约0.1%至约10%的STPP。
本发明的另一些实施方案包含用以调节组合物的流变性和感觉的各种洁牙剂成分,例如表面活性剂、增稠剂或胶凝剂等。
本发明的一些实施方案提供了包含亚锡离子或亚锡离子源的口腔护理组合物。合适的亚锡离子源包括但不限于氟化亚锡、其他卤化亚锡例如氯化亚锡二水合物,焦磷酸亚锡,有机亚锡羧酸盐例如亚锡的甲酸盐、乙酸盐、葡糖酸盐、乳酸盐、酒石酸盐、草酸盐、丙二酸盐和柠檬酸盐,乙二醇亚锡(stannous ethylene glyoxide)等。一种或更多种亚锡离子源任选地且说明性地以约0.01%至约10%,例如约0.1%至约7%或约1%至约5%的总量存在。
本发明的一些实施方案提供了包含表面活性试剂(表面活性剂)的口腔护理组合物。合适的表面活性剂包括但不限于C8-C20烷基硫酸盐的水溶性盐、C8-C20脂肪酸的磺化单甘油酯、肌氨酸盐、牛磺酸盐、月桂基硫酸钠、椰油酰基单甘油酯磺酸钠、月桂基肌氨酸钠、月桂基羟乙基磺酸钠(sodium lauryl isoethionate)、月桂醇聚氧乙烯醚羧酸钠(sodium laureth carboxylate)和十二烷基苯磺酸钠、以及椰油酰胺基丙基甜菜碱。
在一些实施方案中,口腔护理组合物包含增稠剂。可以使用任何口腔可接受的增稠剂,包括但不限于卡波姆(也称为羧基乙烯基聚合物),角叉菜胶(也称为爱尔兰苔藓),并且更特别是-角叉菜胶(ι-角叉菜胶),高分子量聚乙二醇(例如可从Dow化学公司获得),纤维素聚合物例如羟乙基纤维素、羧甲基纤维素(CMC)及其盐例如CMC钠,天然树胶例如刺梧桐树胶、黄原胶、阿拉伯树胶和西黄蓍胶,胶体硅酸镁铝,以及胶体二氧化硅和/或气相二氧化硅及其混合物。一种或更多种增稠剂任选地以约0.1%至约90%,例如约1%至约50%或约5%至约35%的总量存在。
如果需要的话,本发明的另一些实施方案任选地在组合物中包含香料、甜味剂、着色剂、泡沫调节剂、口感剂和/或附加的其他物质。
本发明的又一些实施方案包含一种或更多种额外的活性物质,其可操作用于预防或治疗口腔的硬组织或软组织的病症或障碍、预防或治疗生理障碍或病症,或提供美容益处。这样的另外的活性成分的实例包括催涎剂(sialagogue)或唾液刺激剂、抗牙斑剂(antiplaque agent)、抗炎剂和/或脱敏剂。
也可以将黏附增强剂添加至口腔护理组合物中,所述黏附增强剂包括但不限于蜡,包括蜂蜡,矿物油,塑性凝胶(矿物油和聚乙烯的共混物),矿脂,白矿脂,虫胶,versagel(液体石蜡、丁烯/乙烯/苯乙烯氢化共聚物的共混物),聚乙烯蜡,微晶蜡,聚异丁烯,聚乙烯吡咯烷酮/乙酸乙烯酯共聚物,和不溶性聚丙烯酸酯共聚物。
还有效地作为黏附增强剂的是液体亲水性聚合物,包括聚乙二醇,具有通式:HOCH2(CH2OCH2)n1CH2OH(其中n1表示氧亚乙基的平均数量)的环氧乙烷的非离子聚合物。可从Dow Chemical获得的聚乙二醇由诸如200、300、400、600、2000的数字表示,该数字表示聚合物的近似平均分子量,以及式:HO(C2H4O)a1(C3H6O)b1(C2H4O)c1H的环氧乙烷和环氧丙烷的非离子嵌段共聚物。优选选择嵌段共聚物(相对于a1、b1和c1),使得环氧乙烷成分占共聚物分子的按重量计约65%至约75%,并且共聚物的平均分子量为约2,000至约15,000,其中所述共聚物以使得所述组合物在室温下为液体的浓度存在于液体牙齿增白组合物中。
用于实践本发明的特别期望的嵌段共聚物在商业上可从BASF获得,并且被命名为Pluraflo L1220(PEG/PPG 116/66),其平均分子量为约9,800。亲水性聚(环氧乙烷)嵌段平均为聚合物的按重量计约65%。
合成的阴离子聚羧酸盐也可以在本发明的口腔组合物中用作用于洁牙剂组合物中的任何抗菌剂、抗牙垢剂或其他活性剂的功效增强剂。这样的阴离子聚羧酸盐通常以其游离酸或优选部分或更优选完全中和的水溶性碱金属(例如钾并且优选钠)盐或铵盐的形式使用。优选的是马来酸酐或酸与另一种可聚合的烯键式不饱和单体的1∶4至4∶1共聚物,优选分子量(M.W.)为约30,000至约1,800,000,最优选约30,000至约700,000的甲基乙烯基醚/马来酸酐。这些共聚物的实例可从GAF Corporation以商品名(甲基乙烯基醚/马来酸酐)获得,例如AN 139(M.W.500,000)、AN 119(M.W.250,000);S-97医药级(M.W.700,000)、AN 169(M.W.1,200,000-1,800,000)和AN 179(M.W.高于1,800,000);其中优选的共聚物是S-97医药级(M.W.700,000)。
当存在时,以有效实现口腔组合物中的任何抗菌剂、抗牙垢剂或其他活性剂的功效的期望增强的量使用阴离子聚羧酸盐。通常,阴离子聚羧酸盐以按重量计约0.05%至约4%,优选按重量计约0.5%至约2.5%存在于口腔组合物中。
用于本发明的各种实施方案的组合物中的黏合增强剂以按重量计约0%至约20%的量存在。优选地,黏合增强剂以按重量计约2%至约15%的量存在。
本发明的一些实施方案任选地包含增白剂,其包括但不限于:过氧化物化合物,例如过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物、过氧酸、其可药用盐,及其混合物。碱金属和碱土金属的过氧化物包括过氧化锂、过氧化钾、过氧化钠、过氧化镁、过氧化钙、过氧化钡,及其混合物。有机过氧化合物包括过氧化脲(也称为脲过氧化氢)、甘油基过氧化氢、烷基过氧化氢、二烷基过氧化物、烷基过氧酸、过氧酯、二酰基过氧化物、苯甲酰基过氧化物和单过氧基邻苯二甲酸酯/盐,及其混合物。过氧酸及其盐包括有机过氧酸,例如烷基过氧酸;以及单过氧基邻苯二甲酸盐及其混合物;以及无机过氧酸盐,例如碱金属和碱土金属(例如锂、钾、钠、镁、钙和钡)的过硫酸盐、二过硫酸盐、过碳酸盐、过磷酸盐、过硼酸盐和过硅酸盐,及其混合物。在各种实施方案中,过氧化物化合物包括过氧化氢、过氧化脲、过碳酸钠及其混合物。
在一些实施方案中,在本发明的组合物中可以包含非过氧化物增白剂。本文中可用的那些中的增白剂包括非过氧化合物,例如二氧化氯、亚氯酸盐和次氯酸盐。亚氯酸盐和次氯酸盐包括碱金属和碱土金属例如锂、钾、钠、镁、钙和钡的亚氯酸盐和次氯酸盐。非过氧化物增白剂还包括着色剂,例如二氧化钛和羟基磷灰石;颜料;或者染料。在一些实施方案中,增白剂从水性载体分离。在一些实施方案中,增白剂通过增白剂的包封而从水性载体分离。
在某些实施方案中,组合物包含约65%至99.9%的载体和进一步包含的成分,即以下中的一者或更多者:防龋剂、脱敏剂、黏度调节剂、稀释剂、表面活性剂、乳化剂、泡沫调节剂、pH调节剂、研磨剂、口感剂、甜味剂、调味剂、着色剂、防腐剂、氨基酸、抗氧化剂、抗牙垢剂、氟离子源、增稠剂、用于预防或治疗口腔硬组织或软组织的病症或障碍的活性剂、增白剂及其组合。在组合物的另一个实施方案中,组合物包含约80%至99.5%的载体和进一步包含的成分。在组合物的另一个实施方案中,组合物包含约90%至99%的载体和进一步包含的成分。
在一些实施方案中,在本发明的组合物中也可以包含研磨剂抛光材料。在一些实施方案中,研磨剂抛光材料可以为不会过度磨损牙本质的任何材料。这些材料包括例如二氧化硅(包括凝胶和沉淀物)、碳酸钙、正磷酸二钙二水合物、焦磷酸钙、磷酸三钙、聚偏磷酸钙、不溶性聚偏磷酸钠、水合氧化铝、以及树脂磨料材料例如脲和甲醛的颗粒缩合产物,以及其他材料,例如Cooley等人于1962年12月25日在美国专利3,070,510中所公开的(通过引用并入本文)。也可以使用研磨剂的混合物。
在一些实施方案中,研磨剂体系包含二氧化硅。在一个实施方案中,二氧化硅用作研磨剂。在另一个实施方案中,二氧化硅用作增稠剂。在又一个实施方案中,口腔护理组合物包含研磨剂二氧化硅和增稠性二氧化硅二者。
适用于本发明的组合物中的二氧化硅可以通过本领域已知的或将要开发的任何方法来制备,并且如果需要的话,可以进行表面改性以提高颗粒黏附到牙齿表面的能力。实例可以在例如美国专利申请公开第20070104660号中找到,其内容通过引用并入本文。在实施方案中,二氧化硅以总组合物的按重量计5%或更大的量存在于组合物中。或者,二氧化硅可以以按重量计5%、6%、7%、8%、9%、10%、15%、20%或25%的量存在。
在一些实施方案中,二氧化硅包括沉淀二氧化硅。沉淀二氧化硅是二氧化硅(二氧化硅(silicon dioxide),SiO2)的无定形形式,其为白色粉末状材料。沉淀二氧化硅是通过从含有硅酸盐的溶液中沉淀而产生的。在一个实施方案中,沉淀二氧化硅的产生始于碱性硅酸盐溶液与无机酸的反应。在搅拌的同时将硫酸和硅酸钠溶液添加至水中,然后在碱性条件下进行沉淀。搅拌、沉淀的持续时间、反应物的添加速率、其温度和浓度以及pH的选择可以改变二氧化硅的特性。通过在升高的温度下搅拌来避免形成凝胶阶段。在制造过程中将得到的白色沉淀物过滤、洗涤和干燥。
二氧化硅的实例包括可从Evonik获得的105-High、103、113、115、116、117、120、124、153、163、165、167、168、203、9175;可从W.R.Grace获得的750二氧化硅、753二氧化硅、756二氢化硅81二氧化硅、SM 850C二氧化硅、82二氧化硅、SM 500T二氧化硅、SM 614T二氧化硅;可从Solvay获得的63、73、SoftCleanTM、331、43;可从PQ Corporation获得的SORBOSIL AC33、SORBOSIL AC43、SORBOSIL BFG10、SORBOSILBFG50、SORBOSIL BFG51、SORBOSIL BFG52、SORBOSIL BFG54、SORBOSIL CBT60S、SORBOSILCBT70、SORBOSIL BFG100。
在某些实施方案中,二氧化硅包括可从PQ Corporation获得的Sorbosil AC43二氧化硅。在一个实施方案中,AC43二氧化硅的特性包括:平均颗粒尺寸为2.7微米至4.0微米(如通过MALVERN MASTERSIZER确定的),筛余物为+45μm,在105℃下的水分损失最大为8.0%,在1000℃下的灼烧损失最大为14.0%,以及在水性悬浮体中的pH为5.5至7.5。
在一些实施方案中,增稠剂二氧化硅是高表面积和内部孔体积的合成无定形沉淀材料,以提供约50ml/20克二氧化硅或更大的吸水量和约200ml/100g二氧化硅或更大的吸油量(按照ASTM D281方法)。可以使用的增稠剂二氧化硅的实例为165、163和153;200和22S(可从Evonik获得);15和SM 660(可从W.R.Grace&Co.获得);(可从印度Madhu Silica获得);以及Tixocil 43B(可从Rhodia获得)。
在另一些实施方案中,本发明的口腔护理组合物包含这样的二氧化硅颗粒:例如,其颗粒尺寸分布为3至4微米;或者作为替代地,颗粒尺寸分布为5至7微米;作为替代地,颗粒尺寸分布为3至5微米;作为替代地,颗粒尺寸分布为2至5微米;或者作为替代地,颗粒尺寸分布为2至4微米。
也可以向本发明的口腔护理组合物中添加碳酸氢钠。碳酸氢钠(也称为小苏打)是一种具有广泛用途的家用产品,包括用于洁牙剂和口腔清洗剂中。其为白色粉末,溶于水,并且除非被稳定化,否则往往在水性体系中释放二氧化碳。
在一些实施方案中,本发明的组合物包含着色剂。在一些实施方案中,着色剂包括颜料。如本文所使用的,“颜料”是合成或天然的水不溶性物质,其向另外的物质赋予颜色。在一些实施方案中,颜料进一步增强牙齿的洁白度。如本领域中已知的,可以通过沉积光学增亮剂、蓝色颜料或蓝色染料来改变白色物质的视觉感知。这种效果通常用于洗衣剂产品中以使白色衣服对人眼显得“更白”。相同的概念已被应用于牙齿增白。参见Colgate-Palmolive Company的PCT公开号WO 2015/099642,其通过引用整体并入本文。
在另一些实施方案中,颜料能够反射足够的光使得经处理的牙齿比其初始颜色可感知地更白。在一些实施方案中,可以对颜料进行着色使得其自然色在紫红色至蓝绿色以内。更特别地,颜料可以是紫色的或蓝色的,例如在国际色彩指数(Color IndexInternational)中列出的那些之一。
在一些实施方案中,组合物中的颜料的量可以为0.01至0.075重量%,例如0.05%。在另一些实施方案中,基于组合物的总量,组合物中的颜料的量可以为0.01至0.05重量%、或按重量计0.03%至0.05%。颜料可以均匀地分布在整个组合物中,或者可以分散在第二相例如条纹或其他共挤出的第二相中。这样的“双相”组合物具有各相可以被不同地着色的优点,从而为消费者提供视觉上更具吸引力的产品。
在一些实施方案中,着色剂包括染料。如本文所使用的,术语“染料”是指有机物质,其在水性介质中基本上是水溶性的(在其中染料保持化学稳定的)。与本公开内容的增白洁牙剂组合物一起使用的染料通常为目前根据《食品药物和化妆品法案》(Food Drug&Cosmetic Act)认证的用于食品和摄入药物中的食用色素添加剂,包括诸如以下染料:FD&C红色3号(四碘荧光素的钠盐)、FD&C黄色5号(4-对磺基苯基偶氮-1-对磺基苯基-5-羟基吡唑-3羧酸的钠盐)、FD&C黄色6号(对磺基苯基偶氮-B-萘酚-6-单磺酸盐的钠盐)、FD&C绿色3号(4-{[4-(N-乙基-对磺基苄基氨基)-苯基]-(4-羟基-2-锍-苯基)-亚甲基}-[1-N-乙基-N-对磺基苄基]-Δ-3,5-环己二烯亚胺]的二钠盐)、FD&C蓝色1号(二苄基二乙基-二氨基三苯基甲醇三磺酸酐的二钠盐)、FD&C蓝色2号(靛蓝的二磺酸的钠盐)、D&C绿色5号、D&C橙色5号、D&C红色21号、D&C红色22号、D&C红色27号、D&C红色28号、D&C红色30号、D&C红色40号、D&C黄色10号,及其各种比例的混合物。
口腔护理组合物中的一种或更多种染料的量可以广泛变化。例如,基于增白洁牙剂组合物的总量,本公开内容的增白洁牙剂组合物中的一种或更多种染料的量可以为0.02重量%至2重量%、或0.02重量%至1.5重量%、或0.02重量%至1重量%、或0.02重量%至0.5重量%、或0.02重量%至0.15重量%、或0.02重量%至0.1重量%。在至少一个实施方案中,一种或更多种染料可以均匀地布置或分散在整个增白洁牙剂组合物中。在另一个实施方案中,一种或更多种染料可以布置或分散在增白洁牙剂组合物的不同相中。例如,一种或更多种染料可以布置或分散在增白洁牙剂组合物的第一相(例如,疏水相)中,以及一种或更多种剩余的染料或者没有染料可以布置或分散在增白洁牙剂组合物的第二相(例如,亲水相)中。
在一些实施方案中,表面活性剂选自C8-20烷基硫酸盐的水溶性盐、C8-20脂肪酸的磺化单甘油酯、肌氨酸盐、牛磺酸盐、月桂基硫酸钠、椰油酰基单甘油酯磺酸钠、月桂基肌氨酸钠、月桂基羟乙基磺酸钠(sodium lauryl isoethionate)、月桂醇聚氧乙烯醚羧酸钠和十二烷基苯磺酸钠、椰油酰胺基丙基甜菜碱,及其混合物。
合适的表面活性剂的另外的实例包括高级脂肪酸单甘油酯单硫酸盐的水溶性盐,例如氢化椰子油脂肪酸的单硫酸化单甘油酯的钠盐;高级烷基硫酸盐,例如月桂基硫酸钠;烷基芳基磺酸盐,例如十二烷基苯磺酸钠;高级烷基磺基乙酸盐,例如月桂基磺基乙酸钠;1,2-二羟基丙烷磺酸酯的高级脂肪酸酯;以及低级脂族氨基羧酸化合物的基本上饱和的高级脂族酰基酰胺,例如在脂肪酸、烷基或酰基中具有12至16个碳的那些;等等。最后提到的酰胺的实例包括N-月桂基肌氨酸,以及N-月桂基肌氨酸、N-肉豆蔻酰基肌氨酸或N-棕榈酰基肌氨酸的钠盐、钾盐和乙醇胺盐。另外包括例如非阴离子聚氧乙烯表面活性剂,例如泊洛沙姆(Poloxamer)407、硬脂醇聚醚(Steareth)30、聚山梨酯20和蓖麻油;以及两性表面活性剂,例如椰油酰胺基丙基甜菜碱(tegobaine)和椰油酰胺基丙基甜菜碱月桂基葡糖苷;环氧乙烷与可与之反应并且具有长的烃链(例如,12至20个碳原子的脂族链)的各种含氢化合物的缩合产物,所述缩合产物(ethoxamer)包含亲水性聚氧乙烯部分,例如聚(环氧乙烷)与脂肪酸、脂肪、醇、脂肪酰胺和其他脂肪部分,以及与环氧丙烷和聚环氧丙烷的缩合产物。
在一些实施方案中,黏度调节剂选自甲基纤维素、羟丙基甲基纤维素、羟乙基丙基纤维素、羟丁基甲基纤维素、羧甲基纤维素,其盐,及其混合物。
在另一些实施方案中,本发明的组合物可以任选地包含另外的口腔可接受的增稠剂,其选自但不限于以下中的一者或更多者:卡波姆,也称为羧基乙烯基聚合物;角叉菜胶,也称为爱尔兰苔藓(Irish moss),更特别地,角叉菜胶(ι-角叉菜胶);高分子量聚乙二醇(例如可从Dow化学公司获得的);纤维素聚合物,例如羟乙基纤维素、羧甲基纤维素(CMC)及其盐,例如CMC钠;天然树胶,例如刺梧桐树胶、黄原胶、阿拉伯树胶和西黄蓍胶;以及胶体硅酸镁铝;及其混合物。任选地,基于组合物的重量,这样的另外的增稠剂以约0.1wt%至约50wt%,例如约0.1wt%至约35wt%或约1wt%至约15wt%的总量存在。
在一些实施方案中,本发明的组合物包含至少一种甜味剂,其可用于例如增强组合物的味道。可以使用任何口腔可接受的天然或人工甜味剂,包括但不限于:右旋糖、蔗糖、麦芽糖、糊精、干燥的转化糖、甘露糖、木糖、核糖、果糖、左旋糖、半乳糖、玉米糖浆(包括高果糖玉米糖浆和玉米糖浆固体)、部分水解的淀粉、氢化淀粉水解产物、山梨糖醇、甘露糖醇、木糖醇、麦芽糖醇、异麦芽酮糖醇(isomalt)、阿司帕坦、纽甜、糖精及其盐、基于二肽的强力甜味剂、甜蜜素(cyclamate)等。
又一些实施方案提供了包含选自以下中的甜味剂的组合物:阿司帕坦、乙酰磺胺酸钾、罗汉果(僧果)水果提取物、纽甜、糖精、甜菊、三氯蔗糖、木糖醇、爱德万甜(advantame)、及其混合物。
一种或更多种甜味剂存在的总量可任选地强烈取决于所选的特定甜味剂,但是基于组合物的总重量,通常为0.005wt.%至5wt.%。
在一些实施方案中,组合物包含氟离子源。氟离子源包括但不限于:氟化亚锡、氟化钠、氟化钾、单氟磷酸钾、单氟磷酸钠、单氟磷酸铵、氟硅酸钠、氟硅酸铵、胺氟化物如奥拉氟(olaflur)(N′-十八烷基三亚甲基二胺-N,N,N′-三(2-乙醇)-二氢氟化物)、氟化铵,及其组合。在某些实施方案中,氟离子源包括氟化亚锡、氟化钠、胺氟化物、单氟磷酸钠,及其混合物。在某些实施方案中,本发明的口腔护理组合物也可以包含足以提供约50ppm至约5000ppm氟离子,例如约100ppm至约1000ppm、约200ppm至约500ppm、或约250ppm氟离子的氟离子源或提供氟的成分。氟离子源可以以约0.001wt.%至约10wt.%,例如约0.003wt.%至约5wt.%、0.01wt.%至约1wt.%、或约0.05wt.%的水平添加至本发明的组合物中。然而,应理解,用于提供适当水平的氟离子的氟化物盐的重量明显基于盐中抗衡离子的重量而变化,并且本领域技术人员可以容易地确定这样的量。
在一些实施方案中,口腔护理组合物呈选自以下的形式:牙膏;液体(例如漱口剂或口腔清洗剂);凝胶;喷雾;或者利用牙托施加于牙齿的组合物。在某些实施方案中,组合物呈牙膏的形式。在一些实施方案中,牙膏适于通过刷涂而施加至牙齿。在另一些实施方案中,口腔护理组合物呈可摄取固体或不可摄取固体的形式(例如片剂或珠粒)。
可以将本文中所述膜冲压成各种形状吸引人的薄片,例如心形、星形、菱形和圆形。
在一些实施方案中,纤维素材料包含低黏度氢丙基甲基纤维素(HPMC)。当使用HPMC作为成膜剂时,优选HPMC的如使用乌氏(Ubbelohde)管黏度计在20℃下以按重量计2%HPMC水溶液确定的黏度在约1毫帕秒(mPa.秒)至约40mPa.秒的范围内。优选地,HPMC在20℃下的黏度为约3mpa.秒至约20mpa.秒。HPMC可从Dow化学公司以商品名Methocel E5 LV商购。Methocel E5 LV是USP级的低黏度HPMC,具有29.1%的甲氧基和9%的羟基丙基取代。其是白色或类白色的自由流动的干粉。作为2wt.%水溶液,如用乌氏管黏度计测量的,其在20℃下的黏度为5.1mPa.秒。
预胶化玉米淀粉是可商购的。优选的淀粉可从Cerestar公司以商品名CerestarPolar Tex-Instant12640获得。该Cerestar淀粉是预胶化的、稳定化的和交联的糯玉米淀粉。它在冷水中是可容易分散的和可容易溶胀的。在其干形式下,其是白色的自由流动的粉末,其中平均薄片尺寸不超过180微米并且85%的薄片小于75微米。其堆积密度为44磅/英尺3。
在一些实施方案中,本发明提供了用于口腔护理组合物中的膜,所述膜包含:聚合物、黏土、蜡或其组合;以及折射率为约1.0至约2.5的颗粒物质。
在一些实施方案中,聚合物选自:水溶性聚合物;水不溶性聚合物;水分散性聚合物;及其两种或更多种的组合。在另一些实施方案中,聚合物包含纤维素材料、乙烯基聚合物、丙烯酸类聚合物(acrylate polymer)、及其两种或更多种的组合。
在又一些实施方案中,纤维素材料包含羟烷基纤维素(例如,羟丙基甲基纤维素(HPMC)、羟丙基纤维素、羟乙基纤维素、甲基纤维素、羧甲基纤维素,及其混合物)。在某些实施方案中,乙烯基聚合物选自:聚乙烯吡咯烷酮;交联聚乙烯吡咯烷酮;聚乙烯吡咯烷酮-乙酸乙烯酯共聚物;聚乙烯醇;羧基乙烯基聚合物;及其两种或更多种的组合。
在一些实施方案中,膜包含天然树胶。在另一些实施方案中,天然树胶选自:藻酸钠;角叉菜胶;黄原胶;阿拉伯树胶(gum acacia);阿拉伯胶(arabic gum);瓜尔胶;短梗霉聚糖;琼脂;甲壳质;壳聚糖;果胶;刺梧桐胶;槐豆胶;西黄蓍胶;淀粉(例如,麦芽糊精、直链淀粉、高直链淀粉、玉米淀粉、马铃薯淀粉、稻淀粉(rice starch)、木薯淀粉、豌豆淀粉、甘薯淀粉、大麦淀粉、小麦淀粉、糯玉米淀粉、改性淀粉(例如羟丙基化高直链淀粉)、糊精、果聚糖(levan)、痂囊腔菌聚糖(elsinan)、麸质);以及其两种或更多种的组合。
在一些实施方案中,颗粒物质选自:锌化合物;钙化合物;亚锡化合物(stannouscompound);及其两种或更多种的组合。在又一些实施方案中,颗粒物质选自:锌氧化物(zinc oxide);焦磷酸钙;磷酸二钙二水合物;碳酸钙;以及锡氧化物(stannic oxide)。在一些实施方案中,颗粒材料包括焦磷酸钙。
在某些实施方案中,颗粒物质的折射率为约1.1至约2.4,任选地约1.2至约2.3、约1.3至约2.2、约1.4至约2.1、约1.5至约2.0、约1.5至约1.9、约1.5至约1.8、约1.5至约1.7、或约1.5至约1.6。
在一些实施方案中,聚合物包含纤维素材料。在又一些实施方案中,膜包含纤维素材料和淀粉。在另一些实施方案中,聚合物和淀粉以约2.5∶1的重量比存在。
在一些实施方案中,纤维素材料包含羟丙基甲基纤维素。在一些实施方案中,基于膜的总重量,纤维素材料以约1wt.%至约20wt.%的量存在。在另一些实施方案中,基于膜的总重量,纤维素材料以约5wt.%至约15wt.%的量存在。在又一些实施方案中,基于膜的总重量,纤维素材料以约7.5wt.%至约12.5wt.%的量存在。又一些实施方案提供了这样的膜,其中基于膜的总重量,纤维素材料以约8wt.%至约10wt.%的量存在。在一些实施方案中,基于膜的总重量,纤维素材料以约9wt.%的量存在。
在某些实施方案中,基于膜的总重量,淀粉以约1wt.%至约5wt.%的量存在。在一些实施方案中,基于膜的总重量,淀粉以约2wt.%至约4.5wt.%的量存在。在又一些实施方案中,基于膜的总重量,淀粉以约3.5wt.%至约4.25wt.%的量存在。又一些实施方案提供了这样的膜,其中基于膜的总重量,淀粉以约3.75wt.%至约4wt.%的量存在。
在一些实施方案中,本发明提供了包含约0.1wt.%至约20wt.%的颗粒材料的膜。在另一些实施方案中,本发明提供了包含约1wt.%至约18wt.%、约5wt.%至约16wt.%、或约10wt.%至约15wt.%的颗粒材料的膜。本发明的又一些实施方案提供了包含约15wt.%的颗粒材料的膜。
在一些实施方案中,膜基本上不含含钛材料。在另一些实施方案中,膜不含含钛材料。在某些实施方案中,含钛材料选自二氧化钛和钛涂覆的云母(titanium coated mica)。
在一些实施方案中,本发明提供了包含增塑剂的膜。在另一些实施方案中,本发明提供了选自以下的增塑剂:甘油;邻苯二甲酸类衍生物;丙二醇;低分子量聚乙二醇;及其两种或更多种的组合。
在一些实施方案中,本发明提供了断裂强度大于约750psi(5,171kPa)的膜。本发明提供了这样的本文中所述膜,其断裂强度大于约1,000psi(6,894kPa)、1,100psi(7,584kPa)、大于约1,250psi(8,618kPa)或大于约1,500psi(10,342kPa)。在多个实施方案中,膜的断裂强度为约750psi(5,171kPa)至约5,000psi(34,470kPa)或约750psi(5,171kPa)至约2,900psi(19,995kPa)。
在某些实施方案中,本发明提供了厚度为约0.01mm至约0.1mm的膜。在另一些实施方案中,本发明提供了厚度为约0.25mm至约0.75mm的膜。在又一些实施方案中,本发明提供了厚度为约0.05mm的膜。
在一些实施方案中,本发明提供包括本文中所述膜中的任一者的口腔护理组合物。在一些实施方案中,本发明提供了包括在40℃下约1个月之后保持基本上不溶解的膜的口腔护理组合物。在一些实施方案中,本发明提供了包括在40℃下约2个月之后保持基本上不溶解的膜的口腔护理组合物。
在另一些实施方案中,本发明提供了包括在60℃下约1个月之后保持基本上不溶解的膜的口腔护理组合物。在另一些实施方案中,本发明提供了包括在60℃下约2个月之后保持基本上不溶解的膜的口腔护理组合物。
又一些实施方案提供了这样的口腔护理组合物,其包含口腔可接受的载体以及多个膜或膜片段,其中每个膜或膜片段包含:折射率为约1.5至约2.0的颗粒物质;纤维素材料;以及多糖;其中纤维素材料和多糖以约2.5∶1的重量比存在;并且其中膜基本上不含含钛材料。
本发明的另一些实施方案提供了清洁哺乳动物对象的口腔表面的方法,其包括将本文中所述膜或组合物中的任一者施用于有此需要的对象的口腔表面。本发明的又一些实施方案提供了还包括冲洗口腔的步骤的方法。
实施例
本文中描述的实例和其他实施方式都是示例性的,并且不旨在限制描述本公开内容的组合物和方法的全部范围。可以在结果基本上相似的情况下在本公开内容的范围内对具体实施方式、材料、组合物和方法进行等效改变、修改和变型。
进行了多个实验以评估本发明的膜的多种特性,例如:不透明性;韧性;以及膜在牙膏中的稳定性。用于评估膜的方法和由这些实验产生的结果在下面描述。
不透明性:使用计量仪测量膜的L*a*b*,并通过下式计算ΔW:W*=((a*-0)2+(b*-0)2+(L*-100)2)1/2;ΔW=W(膜)-W(对照)。ΔW得分越高,膜不透明性越好。统计学上的显著差异被认为是限定不透明性是通过还是失败。中性意指样品的ΔW低于对照,但牙膏的外观仍然良好。
韧性:韧性主要通过在平台上使膜的浆料伸展开的过程来限定。如果膜太黏而无法伸展开,则韧性失败。同时,也使用在干燥之后是否均匀地形成膜来评估韧性。仅平滑且不破损的膜才可以视为韧性通过。
在牙膏中的稳定性:将膜切成正方形条,然后以0.12%的剂量施加在透明牙膏中。然后将牙膏置于60℃的烘箱中一个月以观察条的性能。在牙膏中的稳定性差的情况下,一些条在老化之后溶解在牙膏中。然而,一些条在老化之后仍很好地保留在牙膏中并且在下表中被提及为可接受的。
表1:天然碳酸钙
表2:磷酸二钙二水合物
剂量 | 不透明性 | 韧性 | 在TP中的稳定性 |
0.96% | 中性 | 通过 | 溶解 |
2% | 通过 | 通过 | 溶解 |
3% | 通过 | 通过 | 溶解 |
5% | 通过 | 通过 | 溶解 |
10% | 通过 | 失败 | n/a |
表3:焦磷酸钙
剂量 | 不透明性 | 韧性 | 在TP中的稳定性 |
0.96% | 失败 | 通过 | 溶解 |
7% | 中性 | 通过 | 可接受的 |
10% | 通过 | 失败 | n/a |
表4:HPMC/淀粉比值评估
表5:Dical和Cal Pyro水平优化
10%Dical | 15%Dical | 15%Cal Pyro | |
HPMC(wt.%) | 9.38 | 9.38 | 9.38 |
膜不透明性 | 高 | 高 | 高 |
膜韧性 | 高 | 高 | 可接受的 |
膜稳定性 | 溶解 | 溶解 | 未溶解 |
表6:Cap Pyro水平优化
剂量 | 不透明性 | 韧性 | 在TP中的稳定性 |
0.96% | 失败 | 通过 | 溶解 |
7% | 中性 | 通过 | 可接受的 |
10% | 中性 | 通过 | 可接受的 |
15% | 通过 | 通过 | 可接受的 |
18% | 通过 | 失败 | n/a |
表7:锡氧化物水平优化
剂量 | 不透明性 | 韧性 | 在60℃下1个月 |
0.5% | 失败 | 通过 | n/a |
0.96% | 通过 | 通过 | 通过 |
3% | 通过 | 通过 | 通过 |
5% | 通过 | 通过 | 通过 |
虽然已经参照多个实施方案描述了本发明,为了完全公开本发明,已经相当详细地阐述了这些实施方案,但是这样的实施方案仅是示例性的并且不旨在为限制性的或者表示本发明所有方面的详尽列举。本发明的范围由所附的权利要求确定。此外,对于本领域技术人员将显而易见的是,在不脱离本发明的精神和原理的情况下,可以在这样的详细内容上进行许多改变。
Claims (52)
1.用于口腔护理组合物中的柔性膜,其包含:
二氧化硅;
聚合物;
天然树胶;以及
折射率为约1.0至约2.5的颗粒;
其中所述聚合物与多糖的重量比为约2∶1至约3∶1。
2.根据权利要求1所述的膜,其中所述聚合物选自:水溶性聚合物;水不溶性聚合物;水分散性聚合物;以及其两种或更多种的组合。
3.根据权利要求2所述的膜,其中所述聚合物包含纤维素材料;乙烯基聚合物;丙烯酸类聚合物;以及其两种或更多种的组合。
4.根据权利要求3所述的膜,其中所述纤维素材料包含羟烷基纤维素(例如,羟丙基甲基纤维素(HPMC)、羟丙基纤维素、羟乙基纤维素、甲基纤维素、羧基甲基纤维素及其混合物)。
5.根据权利要求3或权利要求4所述的膜,其中所述乙烯基聚合物选自:聚乙烯吡咯烷酮;交联聚乙烯吡咯烷酮;聚乙烯吡咯烷酮-乙酸乙烯酯共聚物;聚乙烯醇;羧基乙烯基聚合物;以及其两种或更多种的组合。
7.根据任一前述权利要求所述的膜,其中所述天然树胶选自:藻酸钠;角叉菜胶;黄原胶;阿拉伯树胶;阿拉伯胶;瓜尔胶;短梗霉聚糖;琼脂;甲壳质;壳聚糖;果胶;刺梧桐胶;槐豆胶;西黄蓍胶;淀粉(例如,麦芽糊精、直链淀粉、高直链淀粉、玉米淀粉、马铃薯淀粉、稻淀粉、木薯淀粉、豌豆淀粉、甘薯淀粉、大麦淀粉、小麦淀粉、糯玉米淀粉、改性淀粉(例如羟丙基化高直链淀粉)、糊精、果聚糖、痂囊腔菌聚糖、麸质);以及其两种或更多种的组合。
8.根据任一前述权利要求所述的膜,其中所述颗粒包含:锌化合物;钙化合物;亚锡化合物;或者其两种或更多种的组合。
9.根据任一前述权利要求所述的膜,其中所述颗粒包含:锌氧化物;焦磷酸钙;磷酸二钙二水合物;碳酸钙;锡氧化物;或者其两种或更多种的组合。
10.根据任一前述权利要求所述的膜,其中所述颗粒的折射率为约1.1至约2.4,任选地约1.2至约2.3、约1.3至约2.2、约1.4至约2.1、约1.5至约2.0、约1.5至约1.9、约1.5至约1.8、约1.5至约1.7、或约1.5至约1.6。
11.根据任一前述权利要求所述的膜,其中所述聚合物包含纤维素材料。
12.根据任一前述权利要求所述的膜,其中所述天然树胶包含淀粉。
13.根据任一前述权利要求所述的膜,其中所述聚合物和所述天然树胶以约2.8∶1的重量比存在。
14.根据权利要求3至13中任一项所述的膜,其中所述纤维素材料包含羟丙基甲基纤维素。
15.根据权利要求3至14中任一项所述的膜,其中基于所述膜的总重量,所述纤维素材料以约1wt.%至约20wt.%的量存在。
16.根据权利要求3至15中任一项所述的膜,其中基于所述膜的总重量,所述纤维素材料以约5wt.%至约15wt.%的量存在。
17.根据权利要求13至16中任一项所述的膜,其中基于所述膜的总重量,所述纤维素材料以约7.5wt.%至约12.5wt.%的量存在。
18.根据权利要求3至17中任一项所述的膜,其中基于所述膜的总重量,所述纤维素材料以约8wt.%至约11wt.%的量存在。
19.根据权利要求3至18中任一项所述的膜,其中基于所述膜的总重量,所述纤维素材料以约10.5wt.%至约11wt.%(例如10.73wt.%)的量存在。
20.根据任一前述权利要求所述的膜,其中基于所述膜的总重量,所述天然树胶以约1wt.%至约5wt.%的量存在。
21.根据任一前述权利要求所述的膜,其中基于所述膜的总重量,所述天然树胶以约2wt.%至约4.5wt.%的量存在。
22.根据任一前述权利要求所述的膜,其中基于所述膜的总重量,所述天然树胶以约3.5wt.%至约4.25wt.%的量存在。
23.根据任一前述权利要求所述的膜,其中基于所述膜的总重量,所述天然树胶以约3.75wt.%至约4wt.%的量存在。
24.根据任一前述权利要求所述的膜,其包含约0.1wt.%至约20wt.%的所述颗粒。
25.根据任一前述权利要求所述的膜,其包含约0.5wt.%至约19wt.%、约1wt.%至约18wt.%、约2wt.%至约17.5wt.%、约3wt.%至约15wt.%、约4wt.%至约或约10wt.%、或约5wt.%至约8wt.%的所述颗粒。
26.根据任一前述权利要求所述的膜,其包含约0.5wt.%、1wt.%、3wt.%或约5wt.%的所述颗粒。
27.根据权利要求26所述的膜,其中所述颗粒包含亚锡化合物。
28.根据权利要求27所述的膜,其中所述亚锡化合物是锡氧化物。
29.根据任一前述权利要求所述的膜,其中所述二氧化硅包括高清洁二氧化硅。
30.根据任一前述权利要求所述的膜,其中所述膜基本上不含含钛材料。
31.根据任一前述权利要求所述的膜,其中所述膜不含含钛材料。
32.根据权利要求30或权利要求31所述的膜,其中所述含钛材料选自二氧化钛和钛涂覆的云母。
33.根据任一前述权利要求所述的膜,其还包含增塑剂。
34.根据权利要求33所述的膜,其中所述增塑剂选自:甘油;邻苯二甲酸类衍生物;丙二醇;低分子量聚乙二醇;以及其两种或更多种的组合。
35.根据任一前述权利要求所述的膜,其还包含香料。
36.根据权利要求35所述的膜,其中所述香料包含薄荷醇或其衍生物。
37.根据任一前述权利要求所述的膜,其中所述膜的断裂强度大于约750psi。
38.根据任一前述权利要求所述的膜,其中所述膜的厚度为约0.01mm至约0.1mm。
39.根据任一前述权利要求所述的膜,其中所述膜的厚度为约0.25mm至约0.75mm。
40.根据任一前述权利要求所述的膜,其中所述膜的厚度为约0.05mm。
41.根据任一前述权利要求所述的膜,其还包含着色剂。
42.根据任一前述权利要求所述的膜,其还包含抗菌剂。
43.口腔护理组合物,其包含根据任一前述权利要求所述的膜;以及口腔可接受的载体。
44.根据权利要求43所述的口腔护理组合物,其中所述膜在40℃下在约2个月之后保持基本上不溶解。
45.根据权利要求43或权利要求44所述的口腔护理组合物,其中所述膜在60℃下在约1个月之后保持基本上不溶解。
46.口腔护理组合物,其包含:
口腔可接受的载体;以及
多个膜或膜片段,其中每个膜或膜片段包含:
二氧化硅;
折射率为约1.5至约2.0的颗粒;
纤维素材料;以及
多糖;
其中所述纤维素材料和所述多糖以约2.5∶1的重量比存在;并且
其中所述膜基本上不含含钛材料。
47.根据权利要求46所述的口腔护理组合物,其中所述颗粒材料包括难溶性亚锡化合物。
48.根据权利要求46或权利要求47所述的口腔护理组合物,其中所述颗粒包含锡氧化物。
49.根据权利要求46至48中任一项所述的口腔护理组合物,其中所述纤维素材料包含羟丙基甲基纤维素。
50.根据权利要求46至49中任一项所述的口腔护理组合物,其中所述多糖包含淀粉。
51.清洁哺乳动物对象的口腔表面的方法,其包括将根据权利要求43至50中任一项所述的组合物施用于有此需要的对象的口腔表面。
52.根据权利要求51所述的方法,其还包括冲洗口腔。
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