CN114431840A

CN114431840A - Pulse acquisition device, pulse acquisition method and system

Info

Publication number: CN114431840A
Application number: CN202210362253.8A
Authority: CN
Inventors: 杨婕; 王新安; 李秋平; 尚怡辰; 王丹
Original assignee: Peking University Shenzhen Graduate School
Current assignee: Peking University Shenzhen Graduate School
Priority date: 2022-04-08
Filing date: 2022-04-08
Publication date: 2022-05-06

Abstract

According to the pulse acquisition device, the pulse acquisition method and the pulse acquisition system, the pulse acquisition device applies continuously-changing pressure to the measured object, and acquires a group of pulse signals of the measured object under the continuously-changing pressure, so that the pulse signals are richer and more diverse. Then finding out the target pulse signal with the maximum peak value in the group of pulse signals, and taking the target pulse signal as the pulse signal of the middle pulse; or extracting the upper envelope of the group of pulse signals, and taking the target pulse signal corresponding to the maximum value of the upper envelope as the pulse signal of the midpulse. And then, the pulse signals of the deep pulse and the superficial pulse are obtained according to the pressure and the pulse signals of the middle pulse, so that the automatic identification of the three pulse conditions of the deep pulse, the superficial pulse and the superficial pulse is realized, and the automation degree of detection is improved.

Description

Pulse acquisition device, pulse acquisition method and system

Technical Field

The invention relates to the field of medical instruments, in particular to a pulse acquisition device, a pulse acquisition method and a pulse acquisition system.

Background

The Pulse (Pulse) is the palpable arterial Pulse of the human body surface. Pulse taking is also called pulse feeling, which is a diagnostic method for TCM to understand the intrinsic changes of disease by pressing the arteries of a patient with hands according to the pulse condition. The pulse-taking is composed of the appearance (deep or shallow), speed (fast or slow), intensity (forceful or weak), rhythm (regular or not, with or without pause) and morphology of the artery pulse. The pulse condition is an important basis for the syndrome differentiation of traditional Chinese medicine, and has important clinical significance for distinguishing the causes of diseases, deducing the changes of the diseases, identifying the true and false of the disease conditions, judging the prognosis of the diseases and the like.

The pulse diagnosis of the traditional Chinese medicine lacks of quantitative standards, and is often 'easy to get in the heart and difficult to understand under the fingers'. Modern pulse diagnosis in traditional Chinese medicine requires objectification and standardization, and influence and persuasion of traditional Chinese medicine can be further expanded only by collecting reliable pulse data by a scientific method and carrying out standard explanation on traditional Chinese medicine diagnosis and treatment by using advanced scientific means such as big data or artificial intelligence.

Compared with modern medicine, the modernization of traditional Chinese medicine is relatively slow, and the important reason is that the traditional Chinese medicine lacks modern research equipment suitable for exerting the advantages of the traditional Chinese medicine.

To effectively treat the disease, correct diagnosis is needed, and the correct pulse acquisition directly determines the pulse diagnosis effect. The pulse condition is complicated and complicated, and the stable and reliable collection of pulse information, which is influenced by factors such as the weather, age, sex, constitution, work and rest, mental state and the like, is the cornerstone of all modern pulse diagnosis.

When pulse diagnosis information is collected, the pulse part, the pulse process and the pulse information quantity can all influence the clinical syndrome differentiation and treatment. Theoretically, the more abundant and effective the collected information, the more accurate the syndrome differentiation result. In the prior art, the pulse sensor is used for detecting the pulse of a patient under a certain pressure, and the obtained pulse signal is single, so that the subsequent diagnosis and treatment of doctors are not facilitated.

Disclosure of Invention

The application provides a pulse acquisition device, a pulse acquisition method and a pulse acquisition system, and aims to solve the problem of single pulse signal.

An embodiment provides a pulse acquisition system comprising:

the pulse acquisition device is used for applying continuously-changed pressure to the measured object and acquiring a group of pulse signals of the measured object under the continuously-changed pressure;

a pulse processing device for:

finding a target pulse signal with the maximum peak value in the group of pulse signals, and taking the target pulse signal as a pulse signal of a midpulse; or extracting the upper envelopes of the group of pulse signals, searching the maximum value of the upper envelopes to obtain a target pulse signal corresponding to the maximum value, and taking the target pulse signal as the pulse signal of the midpulse;

the continuously changed pressure is continuously reduced pressure, the pulse signal at a first preset position before the target pulse signal is used as a pulse signal of deep pulse, and the pulse signal at a second preset position after the target pulse signal is used as a pulse signal of superficial pulse; or, the continuously changing pressure is continuously increased pressure, the pulse signal at a third preset position before the target pulse signal is taken as a pulse signal of a superficial pulse, and the pulse signal at a fourth preset position after the target pulse signal is taken as a pulse signal of a deep pulse.

In one embodiment, a pulse acquisition system is provided,

the pulse signal at a first preset position before the target pulse signal is used as a pulse signal of a deep pulse, and the pulse signal at a second preset position after the target pulse signal is used as a pulse signal of a superficial pulse, and the method comprises the following steps:

finding out a pulse signal with a peak value or an upper envelope corresponding to the amplitude value as a target amplitude value from pulse signals before the target pulse signal, and taking the pulse signal as a pulse signal of a deep pulse; the target amplitude is half of a peak-to-peak value of the target pulse signal, or is half of an amplitude corresponding to an upper envelope of the target pulse signal;

finding out the pulse signal with the peak value or the upper envelope corresponding to the amplitude value as the target amplitude value from the pulse signals behind the target pulse signal, and taking the pulse signal as the pulse signal of the floating pulse;

taking the pulse signal at the third preset position before the target pulse signal as the pulse signal of the superficial pulse, and taking the pulse signal at the fourth preset position after the target pulse signal as the pulse signal of the deep pulse, including:

finding out a pulse signal with the peak value or the upper envelope corresponding to the amplitude value of the target amplitude value from pulse signals before the target pulse signal, and taking the pulse signal as a pulse signal of a superficial pulse;

and finding out the pulse signal with the peak value or the upper envelope corresponding to the target amplitude from the pulse signals behind the target pulse signal, and taking the pulse signal as the pulse signal of the deep pulse.

An embodiment provides a pulse acquisition system, further including: taking adjacent pulse signals before and after the target pulse signal as pulse signals of the midpulse;

taking the pulse signals adjacent to the front and the back of the first preset position as pulse signals of deep pulse, and taking the pulse signals adjacent to the front and the back of the second preset position as pulse signals of superficial pulse; alternatively, the first and second electrodes may be,

and taking the pulse signals adjacent to the front and back of the third preset position as the pulse signals of the superficial pulse, and taking the pulse signals adjacent to the front and back of the fourth preset position as the pulse signals of the deep pulse.

In the pulse acquisition system provided by an embodiment, the pulse acquisition device comprises a piezoelectric pulse sensor; the piezoelectric pulse sensor comprises a sensor probe and a conditioning circuit; the sensor probe comprises a convex part, an arched part and a piezoelectric film; the bulge is arranged at the top of the arch part and is used for contacting with a measured object; the bottom of the arched part is arched, and the piezoelectric film is attached to the bottom of the arched part; the conditioning circuit is electrically connected with the piezoelectric film.

In the pulse acquisition system provided by an embodiment, the pulse acquisition device further comprises a pressurizing module for applying continuously variable pressure to the measured object; the pressurizing module includes:

an air bag for pressurizing the sensor probe;

the air pump is used for inflating the air bag;

the electromagnetic valve is used for deflating the air bag;

and the air pressure sensor is used for acquiring the air pressure of the air bag.

In one embodiment, a pulse acquisition system is provided,

the pulse acquisition device further comprises a controller; the controller is used for controlling the electromagnetic valve to close an air discharging path of the air bag, controlling the air pump to start working and charging the air bag, applying continuously changing pressure to the sensor probe when the air bag is charged, controlling the air pump to stop working after the air pressure is gradually increased to a preset peak pressure according to the air pressure detected by the air pressure sensor, controlling the electromagnetic valve to discharge the air bag to gradually attenuate the air pressure to atmospheric pressure, and acquiring a signal output by the conditioning circuit during the period to obtain a group of pulse signals of the measured object under the continuously changing pressure; alternatively, the first and second electrodes may be,

the pulse processing device is used for controlling the electromagnetic valve to close an air discharge path of the air bag, controlling the air pump to start working and inflating the air bag, applying continuously changing pressure to the sensor probe when the air bag is inflated, controlling the air pump to stop working after the air pressure is gradually increased to a preset peak pressure according to the air pressure detected by the air pressure sensor, controlling the electromagnetic valve to discharge the air bag to gradually attenuate the air pressure to atmospheric pressure, and acquiring a group of pulse signals of the measured object under the continuously changing pressure by the signals output by the conditioning circuit during the period.

An embodiment provides a pulse acquisition system, wherein before the pulse acquisition device applies the continuously variable pressure to the object to be measured, the pulse acquisition device is further configured to:

acquiring an initial pulse signal of a detected object, judging whether the amplitude of the initial pulse signal is lower than a preset adjusting threshold value, and if so, improving the gain of subsequent pulse signals.

In the pulse collecting system according to an embodiment, the piezoelectric pulse sensor further includes a PCB board, the conditioning circuit is disposed on the PCB board, and the conditioning circuit includes a differential sub-circuit; and the components of the differential sub-circuit are symmetrically distributed on the PCB.

An embodiment provides a pulse acquisition method, comprising:

applying continuously variable pressure to the measured object, and collecting a group of pulse signals of the measured object under the continuously variable pressure;

One embodiment provides a pulse acquisition device, which comprises a piezoelectric pulse sensor and a pressurizing module used for applying continuously-changed pressure to a measured object;

the piezoelectric pulse sensor comprises a sensor probe and a conditioning circuit; the sensor probe comprises a convex part, an arched part and a piezoelectric film; the bulge is arranged at the top of the arch part and is used for contacting with a measured object; the bottom of the arched part is arched, and the piezoelectric film is attached to the bottom of the arched part; the conditioning circuit is electrically connected with the piezoelectric film;

the pressurizing module includes:

an air bag for pressurizing the sensor probe;

the air pump is used for inflating the air bag;

the electromagnetic valve is used for deflating the air bag;

According to the pulse acquisition device, the pulse acquisition method and the pulse acquisition system of the embodiment, the pulse acquisition device applies continuously-changing pressure to the measured object to acquire a group of pulse signals of the measured object under the continuously-changing pressure, so that the pulse signals are richer and more diverse. Then finding out the target pulse signal with the maximum peak value in the group of pulse signals, and taking the target pulse signal as the pulse signal of the middle pulse; or extracting the upper envelope of the group of pulse signals, and taking the target pulse signal corresponding to the maximum value of the upper envelope as the pulse signal of the midpulse. And then, the pulse signals of the deep pulse and the superficial pulse are obtained according to the pressure and the pulse signals of the middle pulse, so that the automatic identification of the three pulse conditions of the deep pulse, the superficial pulse and the superficial pulse is realized, and the automation degree of detection is improved.

Drawings

FIG. 1 is a block diagram of a pulse acquisition system according to an embodiment of the present invention;

FIG. 2 is a time domain diagram of a set of pulse signals in the pulse acquisition system according to the present invention;

FIG. 3 is a schematic diagram of a pulse curve of a middle pulse in the pulse acquisition system according to the present invention;

fig. 4 is a schematic diagram of a pulse signal corresponding to floating and sinking extracted from a pulse curve in the pulse acquisition system provided by the present invention;

FIG. 5 is a schematic diagram of the pulse curve of deep pulse in the pulse acquisition system according to the present invention;

FIG. 6 is a schematic diagram of the pulse curve of a superficial pulse in the pulse acquisition system according to the present invention;

FIG. 7 is a schematic diagram of a pulse acquisition system according to the present invention showing three floating, middle and deep pulses;

FIG. 8 is a block diagram of a piezoelectric pulse sensor in the pulse acquisition system according to the present invention;

FIG. 9 is a front view of a sensor probe in the pulse acquisition system of the present invention;

FIG. 10 is a top view of a sensor probe in the pulse acquisition system of the present invention;

FIG. 11 is a circuit diagram of a differential sub-circuit in the pulse acquisition system according to the present invention;

fig. 12 is a schematic distribution diagram of components of a differential sub-circuit on a PCB in the pulse acquisition system according to the present invention;

FIG. 13 is a block diagram of a pressurizing module in the pulse acquiring system according to the present invention;

fig. 14 is a flowchart of a pulse acquisition method in the pulse acquisition system according to the present invention.

Detailed Description

The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to a person skilled in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

As shown in fig. 1, the pulse acquiring system of the present invention includes a pulse acquiring device 10 and a pulse processing device 20. The pulse acquiring device 10 and the pulse processing device 20 may communicate with each other through a wired connection or a wireless connection. The present embodiment is described by taking a wireless communication connection as an example. The pulse collecting device 10 includes a wireless communication module, such as a bluetooth module, a 4G module, a 5G module, etc.

The pulse acquiring device 10 is used for applying a continuously changing pressure to the object to be measured, acquiring a group of pulse signals of the object to be measured under the continuously changing pressure, and transmitting the group of pulse signals to the pulse processing device 20, for example, the group of pulse signals is transmitted to the pulse processing device 20 through the wireless communication module in this embodiment. The continuously variable pressure may be a continuously decreasing pressure or a continuously increasing pressure, and the present embodiment is described by taking the former as an example. After the pulse collecting device 10 increases the pressure to the preset peak pressure, the pressure is gradually attenuated, so that the continuously reduced pressure is formed. The pulse of the tested object is measured during the continuous reduction of the pressure to obtain a group of pulse signals. In this embodiment, the pulse acquiring device 10 transmits all the pulse signals measured by the subject to be measured to the pulse processing device 20. The measured object is usually a human, and the specific measurement position may be a wrist position. A group of pulse signals acquired by the pulse acquisition device 10 contain pulses corresponding to different pressures, so that the pulse signals are richer and more diversified.

The pulse processing device 20 is used for processing the pulse signals transmitted by the pulse acquisition device 10 to obtain pulse signals corresponding to the floating and sinking. The pulse acquisition device 10 only transmits a group of pulse signals of the tested object under the continuously changing pressure, and the pulse processing device 20 directly processes the pulse signals. If the pulse acquiring device 10 transmits all the pulse signals of the object, the time domain diagram is shown in fig. 2, where curve a is the pulse curve formed by the pulse signals, and curve b is the pressure curve of the pressure applied by the pulse acquiring device 10. The pulse processing device 20 extracts a set of pulse signals of the subject under the continuously changing pressure, such as the portion of the curve a outlined by the dashed line, and further extracts the pulse curve (signal) corresponding to the floating and sinking from the portion of the pulse curve. The details will be described below.

The way of processing the resulting mid-pulse signal can be varied, two of which are described below:

in the first mode, the pulse processing device 20 finds a target pulse signal having the largest peak-to-peak value (peak-to-peak value) among the pulse signals in the group, and uses the target pulse signal as a pulse signal of a midpulse. There are various ways to find the maximum peak-to-peak value, for example, the envelope of the group of pulse signals can be extracted, and the maximum value of the envelope is the maximum value of the peak-to-peak value.

In the second mode, as shown in fig. 4, the pulse processing device 20 extracts the upper envelopes of the pulse signals, finds the maximum value of the upper envelopes to obtain the target pulse signal corresponding to the maximum value, and uses the target pulse signal as the pulse signal of the midpulse.

Both of the above two ways are to find the pulse signal with the maximum or maximum amplitude as the pulse signal of the midpulse. On the basis, pulse signals within a preset time period containing the target pulse signal can be used as pulse signals of the midpulse. In the present embodiment, the pulse processing device 20 further takes at least the pulse signals adjacent to the target pulse signal as the pulse signals of the midpulse, as indicated by a curve f2 drawn by a dashed box in fig. 3.

In this embodiment, the continuously variable pressure provided by the pulse acquiring device 10 is a continuously reduced pressure. The great force of pressing the wrist corresponding to the sunken pulse is great, so the pulse processing device 20 takes the pulse signal at the first preset position before (with great pressure) the target pulse signal as the pulse signal of the sunken pulse, and takes the pulse signal at the second preset position after (with small pressure) the target pulse signal as the pulse signal of the superficial pulse.

The first preset position and the second preset position may be set according to doctor's habits, clinical experience, and the like. In this embodiment, the first preset position is: the position of the pulse signal with the target amplitude is corresponding to the peak value or the upper envelope before the target pulse signal. The target amplitude may be a half of a peak-to-peak value of the target pulse signal, or a half of an upper envelope corresponding to the target pulse signal. The pulse processing device 20 finds the pulse signal with the peak value as the target amplitude value from the pulse signals before the target pulse signal and uses the pulse signal as the pulse signal of the sinking pulse, or finds the pulse signal with the corresponding upper envelope as the target amplitude value and uses the pulse signal as the pulse signal of the sinking pulse; that is, the pulse signal enveloped at 1/2 maximum peak-to-peak value or 1/2 maximum peak value before the target pulse signal is regarded as the pulse signal of the deep pulse. Similarly, the pulse signals within a preset time period including the pulse signals of the sunken pulse can be used as the pulse signals of the sunken pulse. In this embodiment, the pulse processing device 20 further uses at least the pulse signals adjacent to each other before and after the first preset position as the pulse signals of the sunken pulse, as shown by a curve f1 selected from a dashed frame in fig. 5.

In this embodiment, the second preset position is: the position of the pulse signal with the target amplitude is behind the target pulse signal, and the peak value or the upper envelope corresponds to the position of the pulse signal with the target amplitude. The pulse processing device 20 finds the pulse signal with the peak value as the target amplitude value from the pulse signals behind the target pulse signal and uses the pulse signal as the pulse signal of the superficial pulse, or finds the pulse signal with the corresponding upper envelope as the target amplitude value and uses the pulse signal as the pulse signal of the superficial pulse; that is, the pulse signal enveloped at 1/2 maximum peak-to-peak value or 1/2 maximum peak value after the target pulse signal is regarded as the pulse signal of the floating pulse. Similarly, the pulse signals within a preset time period including the pulse signals of the floating pulse can be used as the pulse signals of the floating pulse. In this embodiment, the pulse processing device 20 further uses at least the pulse signals adjacent to the second preset position as the pulse signals of the superficial pulse, as shown by a curve f3 selected from the dashed box in fig. 6.

In the embodiment where the continuously changing pressure is a continuously increasing pressure, the pulse processing device 20 takes the pulse signal at the third preset position before the target pulse signal as the pulse signal of the superficial pulse, and takes the pulse signal at the fourth preset position after the target pulse signal as the pulse signal of the deep pulse. The third preset position and the fourth preset position can be set according to doctor habits, clinical experience and the like. In this embodiment, the third preset position is: the position of the pulse signal with the target amplitude is corresponding to the peak value or the upper envelope before the target pulse signal. The pulse processing device 20 finds a pulse signal having a peak-to-peak value as a target amplitude value among pulse signals preceding the target pulse signal and uses the pulse signal as a superficial pulse signal, or finds a pulse signal having an upper envelope corresponding to the target amplitude value and uses the pulse signal as a superficial pulse signal. Similarly, the pulse signals within a preset time period including the pulse signal of the floating pulse can be used as the pulse signals of the floating pulse. In this embodiment, the pulse processing device 20 further uses at least the pulse signals adjacent to each other before and after the third preset position as the pulse signals of the floating pulse. In this embodiment, the fourth preset position is: the position of the pulse signal with the target amplitude is behind the target pulse signal, and the peak value or the upper envelope corresponds to the position of the pulse signal with the target amplitude. The pulse processing device 20 finds a pulse signal having a peak-to-peak value as a target amplitude value among pulse signals subsequent to the target pulse signal and uses the pulse signal as a pulse signal of a deep pulse, or finds a pulse signal having an upper envelope corresponding to the target amplitude value and uses the pulse signal as the pulse signal of the deep pulse. Similarly, the pulse signals within a preset time period including the pulse signals of the sunken pulse can be used as the pulse signals of the sunken pulse. In this embodiment, the pulse processing device 20 further uses at least the pulse signals adjacent to each other before and after the fourth preset position as the pulse signals of the deep pulse.

Therefore, the pulse processing device 20 realizes the automatic identification of the three pulse conditions of floating, middle and deep, and improves the automation degree and accuracy of detection. The pulse processing device 20 may be a host computer, various types of computers, a mobile phone, etc., and may also be integrated with the pulse collecting device 10 to form a medical apparatus for measuring pulse. The pulse processing device 20 includes a display, and the pulse signals corresponding to the floating and sinking pulse signals can be simultaneously displayed in a waveform diagram through the display, as shown in fig. 7, so as to be conveniently viewed by a doctor.

The pulse measurement is very sensitive to pressure, and the traditional Chinese medicine can accurately distinguish the health conditions of different organs according to different forces such as floating, sinking and the like. However, the pulse-taking process is easy to be in mind and is difficult to be clarified, the floating and sinking forces are still indefinite, and different individual body conditions are different, so that a uniform force index cannot be formed. In order to avoid the interference caused by the pressure, the invention adopts a pulse acquisition mode under the continuously variable pressure to measure the pulse signals under the continuously variable pressure, carries out subsequent analysis to form a pulse-pressure curve, combines a large amount of data analysis, adopts the method to extract the floating and sinking signals, obtains rich floating and sinking pulse conditions and solves the problems. As can also be known from the above method for extracting the floating-sinking signal, the floating, middle and sinking defined in the present invention are not a specific pressure value, but are obtained by analyzing and processing the signal itself; can adapt to patients with different pulse conditions, realizes standardized measurement and has good accuracy.

The pulse acquisition device 10 includes a piezoelectric pulse sensor 120. As shown in fig. 8, the piezoelectric pulse sensor 120 includes a sensor probe 121 and a conditioning circuit 122. Referring to fig. 9 and 10, the sensor probe 121 includes a protrusion 1211, an arch 1212, and a piezoelectric film 1213. The projection 1211 is used to make contact with an object to be measured, for example, a wrist of a patient. The projection 1211 is disposed at the top of the arch 1212. The protrusion 1211 and the arch 1212 may be fixed or integrally formed to transmit pressure. The bottom of the arch portion 1212 is arched (curved), and in the embodiment, the bottom of the arch portion 1212 is convexly arched. The bottom of the arch 1212 may be convexly curved, spherical, etc. The piezoelectric film 1213 is attached to the bottom of the arch 1212. The conditioning circuit 122 is electrically connected to the piezoelectric film 1213. In the measuring process, the protruding part can increase the pressure at the contact part of the protruding part and the skin, and accurate positioning and pressure application during testing can be realized more easily. The arch part is designed to cater to the wrist curve of a human body and the deformation direction of the piezoelectric film during pressurization by utilizing the arch shape, so that the extension of the piezoelectric film is facilitated, and the piezoelectric effect is exerted to a greater extent. Thereby improving the accuracy of the pulse measurement.

According to a traditional piezoelectric pulse sensor, a piezoelectric film of the traditional piezoelectric pulse sensor is directly contacted with the skin of a human body, however, myoelectric interference and displacement often exist in the actual measurement process, a large measurement error is caused, and the accuracy is not high. In the sensor probe 121 of the present invention, the force generated by the pulse is transmitted to the arch portion 1212 through the protrusion 1211, and then transmitted to the piezoelectric film 1213 through the arch portion 1212, the force transmission direction is shown by the arrow in fig. 9, and the portion of the piezoelectric film 1213 attached to the arch portion is convex, so as to convert the pulse pressure change in the vertical direction into the horizontal direction, thereby generating the piezoelectric effect and generating the corresponding electrical signal to the conditioning circuit 122. The protruding portion 1211 (protruding point) realizes accurate positioning during pulse measurement, that is, the extra protrusion can more accurately and effectively perform pulse measurement, thereby greatly reducing myoelectric interference and measurement errors caused by displacement in the test process. The sensor probe 121 is placed perpendicular to the radial artery during measurement, and is beneficial to extension of a piezoelectric film after fixation, so that the piezoelectric film can play a piezoelectric effect to a greater extent, generate greater deformation, further generate an electrical signal with a greater amplitude, and effectively improve the signal-to-noise ratio of the signal.

In this embodiment, the piezoelectric film is a polyvinylidene fluoride piezoelectric film (PVDF). The polyvinylidene fluoride piezoelectric film is bonded to the convex bottom surface of the arch portion 1212 by room temperature vulcanized silicone rubber adhesive (RTV).

The diameter of the existing sensor probe is more than 15mm, and the existing sensor probe is used for single-point measurement and meets the use requirement, but the size is large, so that three-point synchronous measurement of cun, guan and chi cannot be carried out, and complete three pulse waves are difficult to obtain. It is also difficult to find sensors that meet both dimensional and accuracy requirements in the industrial field. If the pulse sensor provided by the invention needs to perform multi-point measurement, the width W of the sensor probe 121 can be set to be not more than 10mm, and then one pulse sensor can be provided with three sensor probes 121 to measure pulses of cun, guan and chi respectively, so that pulse signals are enriched, and more sufficient data support is provided for diagnosis and treatment of doctors. Of course, the number of the sensor probes 121 is not limited to one or three, and two or more than three may be provided according to the measurement requirement.

In the conventional pulse sensor, the sensor probe is usually large (small, but the measurement accuracy of the small probe is insufficient) in consideration of the fact that the piezoelectric film needs a large area and the piezoelectric film can effectively contact the wrist. Through the probe structure, the protruding part 1211 does not need to be large, the width W of the sensor probe 121 does not need to be large (such as 10 mm), and the area of the piezoelectric film can be made up from the length direction.

The surface of the projection 1211, which is in contact with the object to be measured, may be a plane, an arc surface, or the like, and even if the wrist of the patient is displaced during measurement, the projection 1211 can be in contact with the surface, so that the pressure caused by the pulse is transmitted to the piezoelectric film 1213 through the arch portion 1212, and the anti-interference capability is strong.

The projection area (projected from top to bottom) of the arch 1212 is larger than the projection area of the projection 1211, and the projection 1211 is disposed at the center of the top of the arch 1212. In other words, the arch 1212 needs to be attached with a piezoelectric film, which has a larger area than the protrusion 1211 and can increase the signal-to-noise ratio of the signal.

The piezoelectric pulse sensor further includes a PCB (not shown) on which the conditioning circuit 122 is disposed. The conditioning circuit 122 includes a differential sub-circuit 1221, the electrical signal generated by the piezoelectric film is transmitted to the differential sub-circuit 1221, and the differential sub-circuit 1221 utilizes the characteristics of common mode rejection and differential mode amplification to reduce interference. The components of the differential sub-circuit 1221 are symmetrically distributed on the PCB. The 50Hz power frequency interference is introduced by commercial power and can not be completely removed, the frequency of the interference is closer to the pulse signal, and if hardware filtering is directly adopted, effective components in the signal can be removed by setting the cut-off frequency to be 20Hz and 30 Hz. The invention utilizes the characteristics of the sensor to output the signals of the piezoelectric film to the differential circuit for processing, greatly reduces power frequency interference by virtue of a completely symmetrical circuit structure and the characteristics of the differential circuit, and effectively shields electromagnetic interference in the air. The piezoelectric film can be connected with the differential sub-circuit 1221 through a double-core shielding wire, so that the anti-interference effect is further improved.

As shown in fig. 11, the differential sub-circuit 1221 according to an embodiment includes a first resistor R1, a second resistor R2, a third resistor R3, a first capacitor C1, a second capacitor C2, a third capacitor C3, a fourth capacitor C4, and an amplifier chip U1. The positive electrode output end IN + of the piezoelectric film 1213 is connected with the + IN end of the amplifier chip U1 and one end of the first resistor R1; the other end of the first resistor R1 is connected with an external first power supply end and is also grounded through a first capacitor C1; the negative electrode output end IN-of the piezoelectric film 1213 is connected with the-IN end of the amplifier chip U1 and one end of the second resistor R2; the other end of the second resistor R2 is connected with an external first power supply end (1/2 VCC) and is grounded through a second capacitor C2; the-VS end of the amplifier chip U1 is grounded, the-RG end of the amplifier chip U1 is connected with the + RG end through a third resistor R3, and the + VS end of the amplifier chip U1 is connected with an external second power supply end (such as a 3.3V voltage supply end) and is also grounded through a third capacitor C3; the REF end of the amplifier chip U1 is connected to an external first power supply end (1/2 VCC) and is also grounded through a fourth capacitor C4; the OUT terminal of the amplifier chip U1 is the output terminal of the differential sub-circuit and is connected to the filter sub-circuit 1222.

Fig. 12 is a layout of the differential sub-circuit on the PCB, where components of the differential sub-circuit are substantially symmetrically distributed, for example, on the PCB, the second resistor R2 and the first resistor R1, the second capacitor C2 and the first capacitor C1, and the third capacitor C3 and the fourth capacitor C4 are substantially symmetrically distributed about a transverse center line (shown by a dotted line).

The conditioning circuit 122 may also include a filtering sub-circuit 1222 and/or an amplifying sub-circuit 1223. The piezoelectric film is connected to the input terminal of the filter sub-circuit 1222 via the differential sub-circuit 1221, and the output terminal of the filter sub-circuit 1222 is connected to the amplifier sub-circuit 1223. The filtering sub-circuit 1222 filters the signal output by the difference sub-circuit 1221, and the amplifying sub-circuit 1223 performs gain amplification on the filtered signal. The components of the filtering sub-circuit 1222 and/or the amplifying sub-circuit 1223 may also be symmetrically distributed on the PCB board. The amplifying sub-circuit 1223 may be an adjustable gain amplifier (VGA), or may be composed of a digital potentiometer and an operational amplifier, so as to achieve gain adjustment.

In some embodiments, the pulse collection device further comprises a wrist band. The sensor probe is fixed on the wrist strap and further fixed on the wrist through the wrist strap.

In this embodiment, the pulse acquiring apparatus includes a pressurizing module 110 for applying a continuously varying pressure to the object to be measured. As shown in fig. 13, the pressurizing module 110 includes an air pressure sensor 111, an air bag 112, an air pump 113, an electromagnetic valve 114, and a driving module 115.

The air bag 112 is used for pressurizing the sensor probe, and the pressure generated by the inflation of the air bag can directly act on the sensor probe or can apply pressure to the back of the wrist or the wrist strap so as to be transmitted to the sensor probe. The sensor probe may be secured to the balloon 112 and then secured to the wrist by the balloon 112, such as a ring balloon, which may be pressurized while restraining the wrist. Of course, the balloon may be secured to the wristband and similarly pressurized after inflation.

The air pump 113 is used to inflate the air bag 112.

The solenoid valve 114 is used to deflate the bladder 112.

The air pressure sensor 111 is used for collecting the air pressure of the air bag 112 and transmitting the air pressure to the controller.

The driving module 115 is used for driving the air pump 113 and the solenoid valve 114.

The pulse acquisition apparatus 10 further includes a controller 130. The process of measuring the pulse of the tested person is as follows: the sensor probe is fixed at the corresponding position of the arm of the tested person through the air bag and/or the wrist strap. The controller 130 controls the electromagnetic valve 114 to close the deflation gas path of the air bag 112, controls the air pump 113 to start working, inflates the air bag 112, applies continuously changing pressure to the sensor probe when the air bag 112 is inflated, controls the air pump 113 to stop working after the air pressure is gradually increased to a preset peak pressure according to the air pressure detected by the air pressure sensor 111, controls the electromagnetic valve 114 to deflate the air bag 112, gradually attenuates the air pressure to atmospheric pressure, and obtains a set of pulse signals of the measured object under the continuously reduced pressure during the period by obtaining the signal output by the conditioning circuit 122. The peak pressure may be set as desired, and may be, for example, 200 mmHg. The controller 130 controls the solenoid valve 114 to deflate the air bag 112, so that the air pressure is gradually attenuated to the atmospheric pressure, specifically, the solenoid valve 114 is partially opened first, the air bag 112 is deflated, the air pressure is gradually attenuated to a preset stage pressure, then the solenoid valve 114 is completely opened to deflate, and the air pressure is recovered to the atmospheric pressure. The stage pressure may be set as required, and may be 40mmHg, for example.

The voltage of the control signal output by the controller 130 may not directly drive the electromagnetic valve 114 and the air pump 113, so that the controller 130 may control the electromagnetic valve 114 and the air pump 113, and the controller 130 may control (drive) the electromagnetic valve 114 and the air pump 113 through the driving module 115.

Of course, the function of the controller 130 can also be performed by the pulse processing device 20, that is, the pulse processing device 20 can control the electromagnetic valve 114 to close the deflation gas path of the air bag 112, control the air pump 113 to start operating, inflate the air bag 112, apply continuously changing pressure to the sensor probe when the air bag 112 is inflated, control the air pump 113 to stop operating after the air pressure is gradually increased to a preset peak pressure according to the air pressure detected by the air pressure sensor 111, and control the electromagnetic valve 114 to deflate the air bag 112, so that the air pressure is gradually attenuated to the atmospheric pressure. During this period, the electrical signal generated by the piezoelectric film is output to the conditioning circuit 122, and is processed by the conditioning circuit 122 to obtain a set of pulse signals of the subject under the continuously reduced pressure, and further transmitted to the pulse processing device 20. The detailed process is the same as above, and is not described herein.

The pulse collection device 10 further includes a power management module 140, and the power management module 140 is used for supplying power to the pulse collection device 10, and for example, includes a battery compartment for accommodating one or more batteries, and a voltage conversion circuit for converting the battery power (e.g. 3V) into 3.3V to be supplied to the conditioning circuit, the voltage boost module 110, the controller 130, and the like, such as 1/2VCC and the 3.3V voltage in fig. 11 can be provided by the power management module 140.

The controller 130 may include an analog-to-digital converter and a processor. The analog-to-digital converter (AD) is responsible for converting the analog signal output by the conditioning circuit into a digital signal and sending the digital signal into the processor. The conversion rate may be 500Hz, and the AD selected may be a 12-bit AD carried by the processor, or may be an AD chip, such as a 12, 16, or 24-bit AD chip. The processor can be various devices with data processing capability, such as an MCU, a singlechip, a microprocessor, an FPGA and the like. MCU is adopted in this embodiment, because the operating current of air pump and solenoid valve is great, MCU's the unable direct drive of IO mouth, so drive module's effect is for receiving come from MCU control signal, increase control current, and then control air pump and solenoid valve's operating condition.

Before the pulse acquisition device 10 applies continuously changing pressure to the object to be measured, an initial pulse signal of the object to be measured can be acquired, whether the amplitude of the initial pulse signal is lower than a preset adjustment threshold value or not is judged, if yes, the gain of the subsequent pulse signal is increased, and the amplitude of the pulse signal after gain amplification exceeds the adjustment threshold value. Therefore, no matter the pulse intensity of the object to be measured, the pulse signal obtained by the pulse processing device 20 can be in an ideal range, and the accuracy of extracting the floating and sinking signals is improved.

For example, the pulse acquisition device 10 acquires 3s of initial pulse signals, the analog-to-digital converter samples at a sampling rate of 500Hz to obtain 1500 data points, and the 1500 data points are sent to the processor (such as MCU). The processor divides the data points into 4 periods, calculates the maximum value and the minimum value of each period, subtracts the maximum value and the minimum value to obtain the amplitude of the period, repeats the steps for four times to obtain four amplitudes, and takes the average value as the amplitude of the initial pulse signal. The adjustment threshold may be set as desired, and may be 2/3 for the range of the analog-to-digital converter, for example. In this embodiment, the measurement range of the adc is 0-3.3V, and the adjustment threshold may be set to 2.2V to fully exhibit the performance. If the amplitude is smaller than 2.2V, the processor performs gradual adjustment and amplification through the amplification sub-circuit 1223, that is, the gain of the amplification sub-circuit 1223 is increased step by step, so that the amplitude exceeds 2.2V. Then, the formal measurement can be started, that is, the pulse acquisition device 10 applies continuously changing pressure to the measured object, and acquires a group of pulse signals of the measured object under the continuously changing pressure. After one measurement is taken, the processor resets the gain of the amplification sub-circuit 1223, e.g. to the initial value, i.e. 1 time. And during the next measurement, whether the gain needs to be adjusted is judged again according to the initial pulse signal.

Some patients are weak and have small pulse amplitude, but the interference signal is not weakened, so the pulse signal needs to be amplified. Before the pressurization starts, the pulse signals of the patient are collected, and if the amplitude is less than 2.2V, the signals need to be amplified by VGA, then the signals are amplified to be more than 2.2V by VGA, and then the pressurization starts to be measured formally. Therefore, no matter the condition of the patient, all pulse signals are between 0 and 3.3V, and the phenomenon of over-range cannot occur; and self-feedback is formed, and the gain of the circuit is automatically regulated and controlled by combining VGA according to the amplitude of pulse waveform, so that the acquired signals are all in an ideal interval, and the subsequent data analysis is facilitated.

In summary, the pulse acquisition system provided by the invention adopts the arched sensor probe with the convex points, so that the problems of unstable data, jitter and the like during acquisition are effectively solved, the signal to noise ratio is greatly improved, and stable support is provided for subsequent data analysis. And the sensor probe is not limited by the contact area of the piezoelectric film any more, so that the sensor probe has extremely strong expansibility, can be proportionally increased and contracted according to test requirements, can be used for single-point pulse acquisition, and can be suitable for multi-point acquisition and even lattice acquisition for subsequently exploring three parts and nine seasons. In order to solve the problem of measurement interference caused by uncertain pressure, the method creatively provides the steps of collecting pulse signals under continuously changing pressure, and slicing data by combining a self-adaptive floating-sinking algorithm to obtain rich floating-sinking signals so as to carry out subsequent analysis. The differential input circuit structure with complete symmetry is adopted, and the signal is transmitted by combining the double-core shielding wire, so that the electromagnetic interference and the power frequency interference in the air are effectively reduced, and the signal-to-noise ratio of the signal is further improved. The gain of the pulse signal is adjusted by self-feedback, the waveform amplitude is automatically judged, and the gain of the circuit is automatically adjusted and controlled by combining the VGA, so that the acquired signals are all in an ideal interval, and the subsequent data analysis is facilitated.

Based on the pulse acquisition provided by the above embodiment, the present invention further provides a pulse acquisition method, as shown in fig. 14, including the following steps:

the pulse acquisition device applies continuously variable pressure to the measured object and acquires a group of pulse signals of the measured object under the continuously variable pressure;

the pulse processing device finds a target pulse signal with the maximum peak value in the group of pulse signals and takes the target pulse signal as a pulse signal of a midpulse; or extracting the upper envelopes of the group of pulse signals, searching the maximum value of the upper envelopes to obtain a target pulse signal corresponding to the maximum value, and taking the target pulse signal as the pulse signal of the midpulse;

the continuously changed pressure is continuously reduced pressure, the pulse processing device takes the pulse signal at a first preset position before the target pulse signal as a pulse signal of deep pulse, and takes the pulse signal at a second preset position after the target pulse signal as a pulse signal of superficial pulse; or, the continuously changing pressure is continuously rising pressure, and the pulse processing device takes the pulse signal at a third preset position before the target pulse signal as a pulse signal of a superficial pulse and takes the pulse signal at a fourth preset position after the target pulse signal as a pulse signal of a deep pulse. The specific process has been described in detail in the embodiment of the system, and is not described herein.

Those skilled in the art will appreciate that all or part of the steps of the various methods in the above embodiments may be implemented by instructions associated with hardware via a program, which may be stored in a computer-readable storage medium, and the storage medium may include: read-only memory, random access memory, magnetic or optical disk, and the like.

The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. Numerous simple deductions, modifications or substitutions may also be made by those skilled in the art in light of the present teachings.

Claims

1. A pulse acquisition system, comprising:

a pulse processing device for:

2. The pulse acquisition system of claim 1,

finding out a pulse signal with the peak value or the upper envelope corresponding to the amplitude value as the target amplitude value from pulse signals behind the target pulse signal, and taking the pulse signal as a pulse signal of a superficial pulse;

3. The pulse acquisition system of claim 1 further comprising: taking adjacent pulse signals before and after the target pulse signal as pulse signals of the midpulse;

4. The pulse acquisition system of claim 1 wherein the pulse acquisition device comprises a piezoelectric pulse sensor; the piezoelectric pulse sensor comprises a sensor probe and a conditioning circuit; the sensor probe comprises a convex part, an arched part and a piezoelectric film; the bulge is arranged at the top of the arch part and is used for contacting with a measured object; the bottom of the arched part is arched, and the piezoelectric film is attached to the bottom of the arched part; the conditioning circuit is electrically connected with the piezoelectric film.

5. The pulse acquisition system of claim 4 wherein the pulse acquisition device further comprises a pressurizing module for applying a continuously varying pressure to the subject; the pressurizing module includes:

an air bag for pressurizing the sensor probe;

the air pump is used for inflating the air bag;

the electromagnetic valve is used for deflating the air bag;

6. The pulse acquisition system of claim 5,

the pulse processing device is used for controlling the electromagnetic valve to close an air discharging gas path of the air bag, controlling the air pump to start working and inflating the air bag, applying continuously changing pressure to the sensor probe when the air bag is inflated, controlling the air pump to stop working after the air pressure is gradually increased to a preset peak pressure according to the air pressure detected by the air pressure sensor, controlling the electromagnetic valve to deflate the air bag, gradually attenuating the air pressure to atmospheric pressure, and acquiring the signal output by the conditioning circuit during the period to obtain a group of pulse signals of the object to be measured under the continuously changing pressure.

7. The pulse acquisition system of claim 1, wherein the pulse acquisition device, prior to applying the continuously varying pressure to the subject, is further configured to:

8. The pulse acquisition system of claim 4 wherein the piezoelectric pulse sensor further comprises a PCB board, the conditioning circuit disposed on the PCB board, the conditioning circuit comprising a differential sub-circuit; and the components of the differential sub-circuit are symmetrically distributed on the PCB.

9. A pulse acquisition method, comprising:

the continuously changed pressure is continuously reduced pressure, the pulse signal at a first preset position before the target pulse signal is used as a pulse signal of deep pulse, and the pulse signal at a second preset position after the target pulse signal is used as a pulse signal of superficial pulse; or the continuously changed pressure is continuously increased pressure, the pulse signal at a third preset position before the target pulse signal is taken as a superficial pulse signal, and the pulse signal at a fourth preset position after the target pulse signal is taken as a deep pulse signal.

10. A pulse acquisition device is characterized by comprising a piezoelectric pulse sensor and a pressurizing module for applying continuously-changed pressure to a measured object;

the pressurizing module includes:

an air bag for pressurizing the sensor probe;

the air pump is used for inflating the air bag;

the electromagnetic valve is used for deflating the air bag;