CN114404707B

CN114404707B - Blood oxygenation device

Info

Publication number: CN114404707B
Application number: CN202111614252.XA
Authority: CN
Inventors: 董凡; 谢庆武; 朱梦晓; 王英
Original assignee: Jafron Biomedical Co Ltd
Current assignee: Jafron Biomedical Co Ltd
Priority date: 2021-12-27
Filing date: 2021-12-27
Publication date: 2023-08-18
Anticipated expiration: 2041-12-27
Also published as: CN114404707A

Abstract

The invention discloses a blood oxygenation device, which comprises a blood input pipeline, a blood output pipeline, an oxygenation branch, a blood purification branch, an oxygenator, a power component, a blood perfusion device, a control system and a first timing component for detecting the continuous working time of the power component; the oxygenator and the power component are connected in series on the oxygenation branch, and the blood perfusion device is arranged on the blood purification branch; the control system is configured to: controlling the oxygenation branch to start working; acquiring feedback information of the first timing component; if the continuous working time of the oxygenation branch is judged to be greater than or equal to the first preset time, a first control signal is sent out; the first control signal is used for indicating that the blood purifying branch is connected to the oxygenation branch so that the oxygenation branch and the blood purifying branch work simultaneously. The invention judges whether to add HP treatment through the control system, does not need medical staff to judge when to add HP treatment according to experience, and is beneficial to the application and popularization of the treatment mode of ECMO+HP.

Description

Blood oxygenation device

Technical Field

The invention relates to the field of medical instruments, in particular to a blood oxygenation device.

Background

The extracorporeal membrane oxygenation (Extracorporeal Membrane Oxygenation, ECMO) treatment technique is mainly used to provide sustained in vitro respiration and circulation to a patient suffering from severe cardiopulmonary failure to maintain the patient's life; the basic principle of ECMO treatment is: leading out blood from Sup>A vein of Sup>A human body, performing pulmonary oxygenation through Sup>A membrane of an oxygenator, removing carbon dioxide in the blood, and returning the oxygenated blood to the vein of the human body (V-V transfer) or to an artery of the human body (V-A transfer); among them ECMO treatments can be classified as: V-V and V-A transitions, wherein V-V transitions are primarily used for in vitro respiratory support, and V-A transitions are used for both in vitro respiratory support and cardiac support. ECMO therapy has been widely applied to patients after cardiac surgery, partially or completely replacing cardiopulmonary function of the patient, equivalent to an "artificial lung" or "artificial heart" outside the patient; depending on clinical treatment requirements, patients typically employ ECMO for a duration of 12 hours to 1 month; particularly, when dealing with the treatment of the new coronary pneumonia, the ECMO technology plays an extremely critical curative role.

The blood perfusion (HP) treatment technology is to directly contact the blood of a patient with an adsorbent in a blood perfusion device, and adsorb metabolites, poisons and the like in the patient through the adsorbent so as to achieve the purpose of removing the metabolites, poisons and the like; the blood perfusion treatment technology is used as one of branches of the blood purification treatment technology, the blood perfusion device is of different types so as to be suitable for different types of disease treatment processes, for example, the blood perfusion device adopts HA380 blood perfusion device produced by Jianshan biotechnology group Co., ltd, wherein the adsorbent in the HA380 blood perfusion device adopts neutral macroporous adsorption resin, and when blood flows into the HA380 blood perfusion device, excessive inflammatory factors and excessive oxidative metabolites in the blood are adsorbed by different acting forces so as to reduce damage to important organs; the HP treatment technology is widely applied to knee toxicity, septic shock, acute respiratory distress syndrome, multiple organ dysfunction syndrome, severe pancreatitis, cardiac surgery, burn complications and the like, and good clinical treatment effects are achieved.

However, there are currently several drawbacks to both ECMO and HP therapy alone, such as the ECMO therapy causing various mechanisms and inflammatory responses in the patient itself, further causing complications such as organ damage and organ dysfunction in the patient; for example, the clinical symptoms suitable for HP treatment are relatively narrow, especially for critical patients caused by new coronaries, the critical patients usually have symptoms such as heart and lung failure, and if HP treatment is adopted alone, the corresponding treatment effect cannot be achieved. For this reason, those skilled in the art combine the advantages of both blood purification treatment techniques and ECMO techniques to address some critically ill patients, such as those caused by new coronaries.

However, at present, when medical staff performs disease treatment by combining HP treatment technology and ECMO technology, the method generally adopted is as follows: after ECMO treatment is performed on the patient for a certain period of time, HP treatment is added through subjective judgment of medical staff. The combined treatment method is dependent on manual subjective judgment, and the medical staff can add HP treatment at any time according to own experience, so that on one hand, the manual operation mode is dependent on clinical treatment experience of the medical staff, mistakes are easy to occur, for example, the medical staff forgets to add the HP treatment mode in the ECMO treatment process, on the other hand, the medical staff lacks a standard operation mode, the addition time point of the HP treatment mode in the ECMO treatment process is easy to be incorrect, and the inflammatory factor removal effect is poor when the patient performs HP treatment; then the inexperienced medical staff does not know how to perform the combined treatment operation of HP and ECMO, and does not adopt the HP+ECMO treatment mode, which is a core problem for limiting the popularization and application of the HP+ECMO treatment mode; therefore, a new therapeutic approach to hp+ecmo is needed to solve this problem.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention aims to provide a blood oxygenation device.

The invention adopts the following technical scheme: a blood oxygenation device, comprising a blood input pipeline, a blood output pipeline, an oxygenation branch, a blood purification branch, an oxygenator, a power component, a blood perfusion device, a first timing component and a control system;

the oxygenator and the power component are arranged on the oxygenation branch line in series, and the blood perfusion device is arranged on the blood purification branch line;

the input end of the oxygenation branch is connected with one end of the blood input pipeline, and the output end of the oxygenation branch is connected with one end of the blood output pipeline;

the input end of the blood purification branch is used for being connected with the output end of the oxygenation branch, and the output end of the blood purification branch is used for being connected with the input end of the oxygenation branch;

the power component is used for providing power for the flow of blood, and the first timing component is used for detecting the continuous working time of the power component;

the control system is configured to:

controlling the oxygenation branch to start working;

acquiring feedback information of the first timing component;

if the continuous working time of the oxygenation branch is judged to be greater than or equal to a first preset time, a first control signal is sent out; the first control signal is used for indicating that the input end of the blood purification branch is connected with the output end of the oxygenation branch and the output end of the blood purification branch is connected with the input end of the oxygenation branch, so that the oxygenation branch and the blood purification branch work simultaneously.

As one embodiment, the blood oxygenation device further comprises a first alarm device, wherein the first control signal is used for controlling the first alarm device to send out a first alarm signal, and the first alarm signal is used for indicating a worker to connect the input end of the blood purification branch to the output end of the oxygenation branch and connect the output end of the blood purification branch to the input end of the oxygenation branch; or alternatively, the process may be performed,

the blood purification branch is provided with a control valve, and the first control signal is used for controlling the control valve to conduct the blood purification branch with the oxygenation branch.

As an embodiment, the control system is further configured to:

and setting the first preset time according to the first blood flow of the oxygenation branch.

As one embodiment, the blood oxygenation device further includes a rotation speed acquisition means for acquiring a rotation speed of the power means;

the control system is further configured to:

and when the oxygenation branch is controlled to start working, controlling the power component to operate at a first rotation speed, and determining the first blood flow of the oxygenation branch according to the first rotation speed.

As an embodiment, the control system is further configured to:

and if the continuous working time of the power component is larger than or equal to the first preset time, controlling the power component to operate at a second rotating speed, wherein the second rotating speed is larger than the first rotating speed.

As an embodiment, the blood oxygenation device further comprises a second timing means for detecting the continuous working time of the blood purification branch;

the control system is further configured to:

acquiring feedback information of the second timing component;

if the continuous working time of the blood purification branch is judged to be more than or equal to the second preset time, a second control signal is sent out; the second control signal is used for indicating that the input end of the purification branch is disconnected with the output end of the oxygenation branch and the output end of the blood purification branch is disconnected with the input end of the oxygenation branch, so that the blood purification branch stops working.

As an embodiment, the control system is further configured to:

and setting the second preset time according to the blood flow of the blood purification branch.

As one embodiment, the blood oxygenation device further comprises a first flow detection means for detecting a blood flow of the blood output line;

The control system is further configured to:

when the blood purification branch circuit works, controlling the power component to operate at a second rotating speed, and determining a second blood flow rate of the oxygenation branch circuit according to the second rotating speed;

and determining the blood flow of the blood purification branch according to the second blood flow of the oxygenation branch and the blood flow of the blood output pipeline.

As an embodiment, the control system is further configured to:

and if the continuous working time of the blood purification branch is larger than or equal to the second preset time, controlling the power component to operate at a third rotating speed, wherein the third rotating speed is smaller than the first rotating speed.

As one embodiment, the blood oxygenation device further comprises a first color detection means for detecting a blood color of the blood output line and a second color detection means for detecting a blood color of the blood input line;

the control system is further configured to:

and determining the treatment effect of the blood oxygenation device according to the blood color of the blood output pipeline and the blood color of the blood input pipeline.

Compared with the prior art, the invention has the beneficial effects that: the control system judges the continuous working time of the oxygenation branch and the first preset time according to the feedback information of the first timing component, and determines whether to send out a first control signal, so as to determine whether to add HP treatment. Therefore, the blood oxygenation device provided by the invention judges whether to add HP treatment through the control system, does not need medical staff to judge when to add HP treatment according to own experience, does not depend on manual subjective judgment any more, can also adopt the ECMO+HP treatment mode even though the medical staff is inexperienced, is beneficial to the application and popularization of the ECMO+HP treatment mode, and is further beneficial to the effective treatment of critical patients.

Drawings

FIG. 1 is a schematic view showing a blood oxygenation device according to an embodiment of the invention;

FIG. 2 is a schematic diagram showing the connection of the blood oxygenation device in a state where the oxygenation branch and the blood purification branch are operated together;

FIG. 3 is a schematic diagram illustrating a connection of a blood oxygenation device according to an embodiment of the invention in a state in which the oxygenation branch is operating alone;

FIG. 4 is a schematic diagram illustrating a control system according to a first embodiment of the present invention;

FIG. 5 is a schematic diagram of the operation of a centrifugal pump according to a first embodiment of the present invention;

FIG. 6 is a schematic view of an oxygenator according to a first embodiment of the present invention;

FIG. 7 is a schematic diagram showing a variation between the exchange efficiency of the oxygenator and the blood flow of the oxygenation branch according to an embodiment of the invention;

fig. 8 is a schematic diagram illustrating a connection of a blood oxygenation device according to a second embodiment of the invention.

In the figure: 100. a blood oxygenation device; 101. a blood inlet line; 102. a blood output line; 103. an oxygenation branch; 104. a blood purification branch; 105. an oxygenator; 1051. an artificial fibrous membrane; 1052. a blood inlet; 1053. a blood outlet; 1054. a gas inlet; 1055. a gas outlet; 106. a power component; 107. A blood perfusion device; 108. a control valve; 20. a control system; 211. a first control module; 212. a second control module; 213. a third control module; 221. a first time judging module; 222. a second time judging module; 231. a first time acquisition module; 232. a second time acquisition module; 24. a flow acquisition module; 251. a first rotational speed setting module; 252. a second rotation speed setting module; 26. a flow calculation module; 271. A first flow judgment module; 272. a second flow judgment module; 28. a color judgment module; 29. a fault judging module; 31. a first timing member; 32. a second timing member; 41. a first alarm device; 42. A second alarm device; 50. a rotation speed acquisition unit; 61. a first flow rate detecting section; 62. a second flow rate detecting section; 71. a first color detection section; 72. a second color detecting section; 80. a physiological parameter detecting component.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and detailed description, wherein it is to be understood that, on the premise of no conflict, the following embodiments or technical features may be arbitrarily combined to form new embodiments. Wherein the arrows in the figure indicate the flow direction of the liquid.

Embodiment one:

referring to fig. 1 to 3, an embodiment of the present invention provides a blood oxygenation device 100, which includes a blood input line 101, a blood output line 102, an oxygenation branch 103, a blood purification branch 104, an oxygenator 105, a power unit 106, a blood perfusion unit 107, a control system 20 and a first timing unit 31. An oxygenator 105 and a power unit 106 are disposed in series on the oxygenation branch 103, and a hemoperfusion cartridge 107 is disposed on the blood purification branch 104. The input end of the oxygenation branch 103 is connected to one end of the blood input line 101, and the output end of the oxygenation branch 103 is connected to one end of the blood output line 102. The input of the blood purification branch 104 is adapted to be connected to the output of the oxygenation branch 103, and the output of the blood purification branch 104 is adapted to be connected to the input of the oxygenation branch 103. The power unit 106 is used for powering the flow of blood, and the first timing unit 31 is used for detecting the continuous operation time of the power unit 106. The control system 20 is configured to: controlling the oxygenation branch 103 to start working; acquiring feedback information of the first timing part 31; if the continuous working time of the oxygenation branch 103 is larger than or equal to the first preset time, a first control signal is sent out; the first control signal is used to instruct the connection of the input of the blood purification branch 104 to the output of the oxygenation branch 103 and the connection of the output of the blood purification branch 104 to the input of the oxygenation branch 103, so that the oxygenation branch 103 and the blood purification branch 104 operate simultaneously. Wherein the first predetermined time is an optimal time for adding a blood perfusion (HP) treatment to the patient after an in vitro epicatechin oxygenation (Extracorporeal Membrane Oxygenation, ECMO) treatment has generated sufficient inflammatory factors.

In this embodiment, by providing the oxygenator 105 and the power unit 106 in series on the oxygenation branch 103, the oxygenation branch 103 can be enabled to perform ECMO treatment on the patient. By providing the blood perfusion apparatus 107 to the blood purification branch 104, the blood purification branch 104 can be subjected to HP treatment for the patient. In practical application, one end of the blood input pipeline 101 is connected with the input end of the oxygenation branch 103, and the other end of the blood input pipeline 101 is connected with a vein of a human body so as to realize venous blood drawing; one end of the blood output line 102 is connected to the output end of the oxygenation branch 103, and the other end of the blood output line 102 is connected to an artery of a human body or a vein of a human body. When the other end of the blood output line 102 is connected to a vein of a human body, V-V inversion is achieved; when the other end of the blood output line 102 is connected to an artery of the human body, V-Sup>A inversion is achieved.

In use, the control system 20 first controls the oxygenation branch 103 to initiate operation to deliver ECMO therapy to the patient alone; if the control system 20 determines that the continuous operation time of the oxygenation branch 103 is greater than or equal to the first preset time according to the feedback information of the first timing unit 31, a first control signal is sent to connect the input end of the blood purification branch 104 to the output end of the oxygenation branch 103 and the output end of the blood purification branch 104 to the input end of the oxygenation branch 103, so that the oxygenation branch 103 and the blood purification branch 104 operate simultaneously, that is, ECMO treatment and HP treatment are performed on the patient simultaneously; if the control system 20 determines that the continuous operation time of the oxygenation branch 103 is less than the first preset time according to the feedback information of the first timing unit 31, the first control signal is not sent out, and the ECMO treatment is continued to be performed on the patient alone. Referring to fig. 3, a schematic diagram of the piping connections for performing ECMO therapy alone is shown.

With the above technical solution, the control system 20 determines, according to the feedback information of the first timing unit 31, the continuous operation time of the oxygenation branch 103 and the first preset time, and determines whether to send out the first control signal, thereby determining whether to add the HP treatment. Therefore, the blood oxygenation device 100 provided in the embodiment of the invention judges whether to add HP treatment through the control system 20, does not need medical staff to judge when to add HP treatment according to own experience, does not rely on artificial subjective judgment any more, and even inexperienced medical staff can also adopt the treatment mode of ecmo+hp, thereby being beneficial to the application and popularization of the treatment mode of ecmo+hp and further beneficial to the effective treatment of critical patients.

Referring to fig. 1 and 4, the control system 20 includes a first control module 211, a first time determination module 221, and a second control module 212. The first control module 211 is used for controlling the oxygenation branch 103 to start working; the first time determining module 221 is configured to obtain feedback information of the first timing component 31, determine whether a continuous operation time of the oxygenation branch 103 is greater than or equal to a first preset time, and send out a first driving signal if the continuous operation time of the oxygenation branch 103 is greater than or equal to the first preset time; the second control module 212 is configured to send out a first control signal according to the first driving signal.

As one embodiment, the power component 106 is a power pump. As a preferred embodiment, the power pump is a centrifugal pump. Fig. 5 shows the working principle of a centrifugal pump, which relies on a pump head to perform high-speed rotation, and transmits kinetic energy to liquid through a rotating impeller or viscous shear force, so that the inner side wall of the pump forms a high-pressure area, and a low-pressure area is formed in the center, the central part of the centrifugal pump is an inlet, and the peripheral part of the centrifugal pump is an outlet, so that the liquid moves unidirectionally from the center to the periphery under the action of pressure difference, and blood in an oxygenation branch flows according to a specific flow direction, wherein a power component 106 is the only power source in the blood oxygenation device 100 provided by the embodiment of the invention. It will be appreciated that in other embodiments, the power pump may be a roll pump.

Referring to fig. 1, the blood oxygenation device 100 further includes a first alarm device 41, where the first control signal is used to control the first alarm device 41 to send a first alarm signal, and the first alarm signal is used to instruct a worker to connect an input end of the blood purification branch 104 to an output end of the oxygenation branch 103 and connect an output end of the blood purification branch 104 to an input end of the oxygenation branch 103. By arranging the first alarm device 41, when the control system 20 judges that the continuous working time of the oxygenation branch 103 is greater than or equal to the first preset time according to the feedback information of the first timing component 31, a first control signal is sent to the first alarm device 41, so that the first alarm device 41 sends a first warning signal to remind a medical staff to add HP treatment.

As one embodiment, the control system 20 is further configured to: the first preset time is set according to the first blood flow of the oxygenation branch 103. In practical applications, the blood flow of the oxygenation branch 103 corresponds to the oxygen exchange rate in the oxygenator 105. As an embodiment, referring to fig. 6, an artificial fiber membrane 1051 is disposed inside the oxygenator 105, and the oxygenator 105 has a blood inlet 1052, a blood outlet 1053, a gas inlet 1054, and a gas outlet 1055, wherein after entering the inside of the oxygenator 105, blood and gas are respectively located on two sides of the artificial fiber membrane 1051, for example, blood is located on the inner side of the artificial fiber membrane 1051, and gas is located on the outer side of the artificial fiber membrane 1051. The carbon dioxide in the blood exchanges with the oxygen in the gas through the artificial fiber membrane 1051 to perform the oxygenation process, and thus the blood output from the oxygenator 105 is oxygen-containing blood. In the oxygenator 105, the exchange efficiency between carbon dioxide in blood and oxygen in gas is affected by the blood flow rate of the oxygenator 105 in addition to the close relationship with the membrane material of the artificial fiber membrane 1051, and since the blood flow rate of the oxygenator 105 is equal to the blood flow rate of the oxygenation branch 103, the exchange efficiency between carbon dioxide in blood and oxygen in gas is affected by the blood flow rate of the oxygenation branch 103, and only when the blood flow rate of the oxygenation branch 103 is in a specific range, the exchange efficiency between carbon dioxide in blood and oxygen in gas is in a specific range. By way of example, fig. 7 shows a graph of the change between the exchange efficiency of the oxygenator 105 and the blood flow of the oxygenation branch 103, the exchange efficiency of the oxygenator 105 being only higher when the blood flow of the oxygenation branch 103 is M0; therefore, when the first time obtaining module 231 obtains the blood flow of the oxygenation branch 103, the oxygenation performance of the oxygenator 105 on the blood of the patient can be obtained according to the curve in fig. 7, so as to determine the satisfaction degree of the oxygenation on the respiratory demand of the human body; when the exchange efficiency of the oxygenator 105 is higher, the oxygen content in the blood output after oxygenation can meet the respiratory requirement of a human body, and the level of inflammatory factors generated in the oxygenation process is higher, the blood needs to be subjected to HP treatment by the blood perfusion device 107 as soon as possible, and the first preset time is shorter, so that the blood perfusion device 107 needs to be adopted to adsorb the inflammatory factors in the blood as soon as possible, and the balance state is maintained; conversely, when the exchange efficiency of the oxygenator 105 is smaller, the level of inflammatory factors generated during the oxygenation process is lower, the first preset time is longer, and after the ECMO treatment is needed to be longer, the blood perfusion device 107 is used to adsorb inflammatory factors in blood, so that the hp+ecmo combined treatment efficiency is improved. Therefore, the blood flow of the oxygenation branch 103 is different, and the corresponding first preset time is different. In this embodiment, the control system 20 sets the first preset time according to the internal connection of the blood flow of the oxygenation branch 103, the exchange efficiency of the oxygenator 105, the inflammatory factor level generated during the oxygenation process, and the first preset time, so as to add the HP treatment at the appropriate time for performing the ECMO treatment, and improve the hp+ecmo combined treatment efficiency. In practical application, a database of a first preset time is provided in the control system 20, and the control system 20 matches the corresponding first preset time according to the blood flow of the oxygenation branch 103.

Referring to fig. 1 and 4, the control system 20 further includes a first time acquisition module 231, where the first time acquisition module 231 is configured to set a first preset time according to the first blood flow of the oxygenation branch 103. By providing the first time acquisition module 231, the control system 20 is enabled to set a first preset time according to the first blood flow of the oxygenation branch 103.

As an embodiment, the blood oxygenation device 100 further comprises a rotational speed obtaining part 50, the rotational speed obtaining part 50 being configured to obtain the rotational speed of the power part 106; the control system 20 is further configured to: when the control oxygenation branch 103 starts to operate, the control power unit 106 is operated at a first rotational speed, and a first blood flow rate of the oxygenation branch 103 is determined based on the first rotational speed. By providing the rotation speed acquisition means 50, the rotation speed of the power means 106 can be acquired, and when the oxygenation branch 103 starts to operate, the power means 106 is operated at the first rotation speed, and the rotation speed acquisition means 50 can detect that the power means 106 is operated at the first rotation speed. The rotational speed obtaining part 50 feeds back the detected information to the control system 20, and the control system 20 determines the first blood flow rate of the oxygenation branch 103 according to the information fed back by the rotational speed obtaining part 50, and sets a first preset time according to the first blood flow rate. In practical applications, the greater the rotational speed of the power member 106, the greater the blood flow rate of the oxygenation branch 103, and the correspondence exists between the rotational speed of the power member 106 and the blood flow rate of the oxygenation branch 103. As one embodiment, there is a correspondence between the rotational speed of the power member 106 and the blood flow rate of the oxygenation branch 103 as shown in table 1. The control system 20 may calculate the blood flow rate of the oxygenation branch 103 according to table 1 when the rotational speed obtaining means 50 obtains the rotational speed of the power means 106, according to the correspondence relation shown in table 1. Alternatively, a database of the correspondence relationship between the rotational speed of the power member 106 and the blood flow rate of the oxygenation branch 103 may be directly stored in the blood oxygenation device 100, and when the rotational speed of the power member 106 is obtained by the rotational speed obtaining member 50, the blood flow rate of the oxygenation branch 103 may be checked from the database.

TABLE 1

Running speed of the power unit (unit: r/min)	Blood flow of oxygenation branch (unit: ml/min)
		20	5
30	6
		40	7
50	8
		60	9

Referring to fig. 1 and 4, the control system 20 further includes a flow rate acquisition module 24, where the flow rate acquisition module 24 is configured to determine the blood flow rate of the oxygenation branch 103 according to the feedback information of the rotational speed acquisition component 50. The first control module 211 is also configured to control the power component 106 to operate at a first rotational speed when the oxygenation branch 103 is controlled to be active. In this embodiment, when the first control module 211 controls the oxygenation branch 103 to start working, the power unit 106 is controlled to operate at the first rotational speed, the rotational speed obtaining unit 50 feeds back the rotational speed information of the power unit 106 to the flow obtaining module 24, and the flow obtaining module 24 determines the first blood flow of the oxygenation branch 103 according to the feedback information of the rotational speed obtaining unit 50 and feeds back the first blood flow information of the oxygenation branch 103 to the first time obtaining module 231.

As one embodiment, the control system 20 is further configured to: if the continuous operation time of the power unit 106 is greater than or equal to the first preset time, the power unit 106 is controlled to operate at a second rotation speed, and the second rotation speed is greater than the first rotation speed. That is, after the HP treatment is added, the power member 106 is operated at a second rotational speed that is greater than the first rotational speed. By this arrangement, the blood flowing from the oxygenation branch 103 after the HP treatment is added partially flows into the purification branch and ensures that there is sufficient blood flow in the purification branch in the preset direction.

Referring to fig. 1 and 4, the control system 20 further includes a first rotational speed setting module 251, where the first rotational speed setting module 251 is configured to control the power component 106 to operate at the second rotational speed according to the first driving signal. By this arrangement, when the control system 20 determines that the continuous operation time of the power unit 106 is greater than or equal to the first preset time, the power unit 106 can be controlled to operate at the second rotational speed.

Referring to fig. 1, the blood oxygenation device 100 further includes a second timing means 32, the second timing means 32 being configured to detect a continuous operation time of the blood purification branch 104; the control system 20 is further configured to: acquiring feedback information of the second timing part 32; if the continuous working time of the blood purification branch 104 is greater than or equal to the second preset time, a second control signal is sent out; the second control signal is used to instruct to disconnect the input of the blood purification branch 104 from the output of the oxygenation branch 103 and disconnect the output of the blood purification branch 104 from the input of the oxygenation branch 103, so that the blood purification branch 104 is stopped. By such arrangement, the control system 20 is used to determine whether to disconnect the HP treatment, so that it is not necessary for the medical staff to determine when to disconnect the HP treatment according to their own experience, and the ECMO+HP treatment mode is easier to be adopted by inexperienced medical staff, which is further beneficial to the application and popularization of the ECMO+HP treatment mode. The second preset time is the time used by the blood purification branch 104 when the effect of removing inflammatory factors in blood is optimal.

Referring to fig. 1 and 4, the control system 20 further includes a second time determination module 222 and a third control module 213. The second time determining module 222 is configured to obtain feedback information of the second timing component 32, determine that the continuous operation time of the blood purification branch 104 is greater than or equal to a second preset time, and send out a second driving signal if the continuous operation time of the blood purification branch 104 is greater than or equal to the second preset time; the third control module 213 is configured to send out a second control signal according to the second driving signal. By this arrangement, the control system 20 can obtain feedback information from the second timing element 32 and can send out a second control signal when it is determined that the continuous operation time of the blood purification branch 104 is greater than or equal to the second preset time.

In this embodiment, the second control signal is used to control the first alarm device 41 to send out a third alarm signal, where the third alarm signal is used to instruct a worker to disconnect the input end of the blood purification branch 104 from the output end of the oxygenation branch 103 and disconnect the output end of the blood purification branch 104 from the input end of the oxygenation branch 103. In practical application, after hearing the third warning signal sent by the first alarm device 41, the medical staff disconnects the blood purification branch 104 from the oxygenation branch 103.

As one embodiment, the control system 20 is further configured to: the second preset time is set according to the blood flow rate of the blood purification branch 104. Wherein, the blood flow of the blood purification branch 104 is different, and the corresponding second preset time is different. In this embodiment, the control system 20 sets the second preset time according to the internal relationship between the blood flow of the blood purification branch 104, the adsorption efficiency of the blood perfusion device 107 to inflammatory factors in blood, and the second preset time. In practical application, a database of second preset time is provided in the control system 20, and the control system 20 matches the corresponding second preset time according to the blood flow of the blood purification branch 104.

Referring to fig. 1 and 4, the control system 20 further includes a second time acquisition module 232, where the second time acquisition module 232 is configured to set a second preset time according to the blood flow of the blood purification branch 104. By providing the second time acquisition module 232, the control system 20 is enabled to set a second preset time according to the blood flow of the blood purification branch 104.

Referring to fig. 1, the blood oxygenation device 100 further includes a first flow detection member 61, the first flow detection member 61 being configured to detect a blood flow of the blood output line 102; the control system 20 is further configured to: when the blood purification branch 104 works, the power component 106 is controlled to operate at a second rotating speed, and the second blood flow of the oxygenation branch 103 is determined according to the second rotating speed; the blood flow of the blood purification branch 104 is determined from the second blood flow of the oxygenation branch 103 and the blood flow of the blood output line 102. In practice, the second blood flow of the oxygenation branch 103 minus the blood flow of the blood output line 102 is equal to the blood flow of the blood purification branch 104. By this arrangement, the blood flow rate of the blood purification branch 104 is determined, thereby further setting the second preset time. In the present embodiment, the first flow rate detecting member 61 detects the blood flow rate of the blood output line 102 by an ultrasonic detection method.

Referring to fig. 1 and 4, the control system 20 further includes a flow calculation module 26, where the flow calculation module 26 is configured to determine the blood flow of the blood purification branch 104 according to the second blood flow of the oxygenation branch 103 and the blood flow of the blood output line 102. In this embodiment, when the blood purification branch 104 is operated, the first rotational speed setting module 251 controls the power unit 106 to operate at the second rotational speed according to the first driving signal, the rotational speed obtaining unit 50 feeds back the detected rotational speed information of the power unit 106 to the flow obtaining module 24, the flow obtaining module 24 determines the second blood flow rate of the oxygenation branch 103 according to the feedback information of the rotational speed obtaining unit 50, and feeds back the second blood flow rate information of the oxygenation branch 103 to the flow calculating module 26, and the first flow detecting unit 61 feeds back the detected blood flow rate information of the blood output line 102 to the flow calculating module 26, and the flow calculating module 26 determines the blood flow rate of the blood purification branch 104 according to the second blood flow rate of the oxygenation branch 103 and the blood flow rate of the blood output line 102.

As one embodiment, the control system 20 is further configured to: if the continuous operation time of the blood purification branch 104 is greater than or equal to the second preset time, the power unit 106 is controlled to operate at a third rotation speed, which is less than the first rotation speed. That is, after the HP treatment is turned off, the power member 106 is controlled to operate at a third rotational speed that is less than the first rotational speed. If the power member 106 is rotated at a second rotational speed, which is greater than the first rotational speed, after the HP treatment is turned off, the blood flow in the blood output line 102 is maintained at a high level, which may cause uncomfortable symptoms (such as chest distress, palpitation, etc.) to the patient, and therefore, in order to ensure safety of the ECMO treatment of the patient after the HP treatment is turned off, the power member 106 is controlled to operate at a third rotational speed to decrease the blood flow of the oxygenation branch 103, thereby maintaining safety of the patient during the treatment.

Referring to fig. 1 and 4, the control system 20 further includes a second rotational speed setting module 252, where the second rotational speed setting module 252 is configured to control the power component 106 to operate at a third rotational speed according to the second driving signal. By this arrangement, the power component 106 can be controlled to operate at the third rotational speed when the control system 20 determines that the continuous operation time of the blood purification branch 104 is greater than or equal to the second preset time.

Referring to fig. 1, the blood oxygenation device 100 further includes a second alarm device 42, where the second alarm device 42 is configured to send a second alarm signal when the operation state of the blood purification branch 104 is abnormal; the control system 20 is further configured to: if the blood flow of the blood purification branch 104 is less than the preset blood flow, the second alarm device 42 is controlled to send out a second alarm signal. The preset blood flow is the minimum blood flow allowed by the blood perfusion device 107. The blood flow of the blood perfusion device 107, that is, the blood flow of the blood purification branch 104, only when the blood flow of the blood perfusion device 107 is greater than or equal to the preset blood flow, the blood perfusion device 107 can exert a corresponding adsorption effect on the blood; if the blood flow of the blood perfusion device 107 is smaller than the preset blood flow, the blood flow obtained by the diversion of the blood purification branch 104 is too small, the blood flow of the blood perfusion device 107 is too small, the blood perfusion device 107 can only adsorb a small amount of blood, and the effect of the HP treatment is poor. In this embodiment, if the control system 20 is configured to determine that the blood flow of the blood purification branch 104 is smaller than the preset blood flow, the second alarm device 42 is controlled to send out the second alarm signal to prompt the medical staff to deal with the failure of too small flow as soon as possible.

Referring to fig. 1 and 4, the control system 20 further includes a first flow determining module 271, where the first flow determining module 271 is configured to determine a difference between the blood flow of the blood purification branch 104 and a preset blood flow, and if the blood flow of the blood purification branch 104 is determined to be less than the preset blood flow, control the second alarm device 42 to send out a second alarm signal.

Referring to fig. 1, the blood oxygenation device 100 further includes a second flow detecting means 62, the second flow detecting means 62 for detecting a blood flow of the blood input line 101; the control system 20 is further configured to: the safe state of the blood oxygenation device 100 is determined from the blood flow rate of the blood input line 101 and the blood flow rate of the blood output line 102. Normally, when ECMO therapy is performed alone or in combination with hp+ecmo therapy, the blood flow of the blood input line 101 and the blood flow of the blood output line 102 are equal or approximately equal, and then the difference between the blood flow of the blood input line 101 and the blood flow of the blood output line 102 is lower than the preset difference (the preset difference is an allowable error); when the difference between the blood flow of the blood inlet line 101 and the blood flow of the blood outlet line 102 is higher than the preset difference, it is indicated that a flow failure occurs in the blood inlet line 101, the blood outlet line 102, the oxygenation branch 103 and the blood purification branch 104, and possible factors causing such a flow failure are: the broken liquid leakage occurs in the pipeline, the liquid blockage in the pipeline, the blood leakage phenomenon occurs at the joint between the blood purification branch 104 and the oxygenation branch 103, and the like. Accordingly, embodiments of the present invention secure clinical treatment of a patient by configuring the control system 20 to determine a treatment safety state of the blood oxygenation device 100 based on the blood flow of the blood inlet line 101 and the blood flow of the blood outlet line 102. In practice, the second flow rate detecting unit 62 detects the blood flow rate of the blood output line 102 by ultrasonic detection.

Referring to fig. 1 and 4, the control system 20 further includes a second flow rate determining module 272, where the second flow rate determining module 272 is configured to detect a difference between the blood flow rate of the blood input line 101 and the blood flow rate of the blood output line 102, and determine a quality safety state of the blood oxygenation device 100 according to the difference.

Referring to fig. 1, the blood oxygenation device 100 further includes a first color detection means 71 and a second color detection means 72, the first color detection means 71 being for detecting a blood color of the blood output line 102, the second color detection means 72 being for detecting a blood color of the blood input line 101; the control system 20 is further configured to: the therapeutic effect of the blood oxygenation device 100 is determined based on the blood color of the blood output line 102 and the blood color of the blood input line 101. When the patient is treated with ECMO or hp+ecmo, the oxygen content of the blood fed to the oxygenator 105 is low, and the oxygen content of the blood fed to the oxygenator 105 is increased after the oxygenation in the oxygenator 105; if the patient is normally treated with ECMO or the combination of HP and ECMO, the exchange efficiency of the oxygenator 105 is maintained at a normal level, and the blood color in the blood output line 102 is different from the blood color in the blood input line 101, the blood color in the blood output line 102 may be actually more reddish than the blood color in the blood input line 101. According to the embodiment of the invention, the control system 20 judges the treatment effectiveness of the blood oxygenation device 100 according to the blood color of the blood output pipeline 102 and the blood color of the blood input pipeline 101, and determines the treatment effect.

In practical application, the first color detecting unit 71 and the second color detecting unit 72 acquire color images of blood in the pipeline through an ultrasonic detecting device, and then an intelligent algorithm or image processing software in the prior art is utilized to obtain RGB values of the blood, and the RGB values are used as standard parameters for evaluating the colors, so that different colors are quantitatively distinguished. Wherein, RGB represents three colors of red, green and blue respectively. When the first color detecting means 71 detects the blood color of the blood output line 102 and derives a first RGB value, and the second color detecting means 72 detects the blood color of the blood input line 101 and derives a second RGB value, the control system 20 determines whether the exchange efficiency of the oxygenator 105 is at a normal level based on the difference between the first RGB value and the second RGB value. For example, when the first RGB value and the second RGB value are not different or almost the same, it indicates that the oxygen content of blood does not change before and after passing through the oxygenation branch 103, and the ECMO treatment or the hp+ecmo combination treatment is in an ineffective state, so that the treatment effect is poor.

In one embodiment, the control system 20 further includes a color determination module 28, wherein the color determination module 28 is configured to determine a difference between the first RGB value and the second RGB value, and determine the therapeutic effect of the blood oxygenation device 100 based on the difference.

Referring to fig. 1, the blood oxygenation device 100 further comprises a physiological parameter detecting means 80, the physiological parameter detecting means 80 being configured to detect a physiological parameter of the patient when the oxygenation branch 103 and the blood purification branch 104 are simultaneously operated; the control system 20 is further configured to: based on the feedback information from the physiological parameter detecting unit 80, the safe state of the blood oxygenation device 100 is determined. The physiological parameters are blood pressure, pulse, heart rate, temperature and the like of a human body, and when ECMO and HP are simultaneously applied to a patient, the risk of anaphylactic reaction of the patient is caused, and the physiological parameters of the patient are detected by the physiological parameter detection part 80 to judge the treatment safety state when ECMO and HP are applied to the patient. For example, when the temperature of the human body is detected to rise sharply, clinical symptoms such as sweating appear, which indicate that the treatment of the human body is abnormal, and medical staff is required to deal with the clinical abnormal state in time.

As an embodiment, the control system 20 further includes a failure determination module 29, and the failure determination module 29 determines the safe state of treatment of the blood oxygenation device 100 according to the feedback information of the physiological parameter detecting means 80.

Embodiment two:

referring to fig. 1 and 8, the difference between the present embodiment and the first embodiment is that the blood purifying branch 104 is connected to and disconnected from the oxygenation branch 103 in a different manner. In the first embodiment, after hearing the first warning signal sent by the first alarm device 41, the medical staff communicates the blood purification branch 104 with the oxygenation branch 103, and after hearing the third warning signal sent by the first alarm device 41, the medical staff disconnects the blood purification branch 104 from the oxygenation branch 103; in this embodiment, the first control signal controls the blood purification branch 104 to be connected to the oxygenation branch 103, and the second control signal controls the blood purification branch 104 to be disconnected from the oxygenation branch 103.

Referring to fig. 1 and 8, the blood purification branch 104 is provided with a control valve 108, a first control signal is used for controlling the control valve 108 to connect the blood purification branch 104 with the oxygenation branch 103, and a second control signal is used for controlling the control valve 108 to disconnect the blood purification branch 104 from the oxygenation branch 103. In practice, the control valve 108 is provided at the input of the blood purification branch 104. When the continuous operation time of the oxygenation branch 103 is greater than or equal to the first preset time, the control system 20 sends a first control signal to control the control valve 108 to be opened, so that the blood purification branch 104 is communicated with the oxygenation branch 103; when the continuous operation time of the blood purification branch 104 is greater than or equal to the second preset time, the control system 20 sends out a second control signal to control the control valve 108 to be closed, so that the blood purification branch 104 is disconnected from the oxygenation branch 103. In this embodiment, the control valve 108 is a one-way valve.

The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present invention are intended to be within the scope of the present invention as claimed.

Claims

1. The blood oxygenation device is characterized by comprising a blood input pipeline, a blood output pipeline, an oxygenation branch, a blood purification branch, an oxygenator, a power component, a blood perfusion device, a first timing component and a control system;

the control system is configured to:

controlling the oxygenation branch to start working;

acquiring feedback information of the first timing component;

2. The blood oxygenation device of claim 1, further comprising a first alarm device, wherein the first control signal is configured to control the first alarm device to emit a first alert signal, the first alert signal being configured to instruct a worker to connect the input of the blood purification branch to the output of the oxygenation branch and the output of the blood purification branch to the input of the oxygenation branch; or alternatively, the process may be performed,

3. The blood oxygenation device of claim 1, wherein the control system is further configured to:

4. A blood oxygenation device according to claim 3, further comprising a rotational speed acquisition means for acquiring a rotational speed of the power means;

the control system is further configured to:

5. The blood oxygenation device of claim 4, wherein the control system is further configured to:

6. The blood oxygenation device of claim 4, further comprising a second timing means for detecting a continuous on time of the blood purification branch;

the control system is further configured to:

acquiring feedback information of the second timing component;

7. The blood oxygenation device of claim 6, wherein the control system is further configured to:

8. The blood oxygenation device of claim 7, further comprising a first flow detection means for detecting a blood flow of the blood output line;

the control system is further configured to:

9. The blood oxygenation device of claim 7, wherein the control system is further configured to:

10. The blood oxygenation device of claim 1, further comprising a first color detection component for detecting a blood color of the blood output line and a second color detection component for detecting a blood color of the blood input line;

The control system is further configured to: