CN114403443A - Drop pill containing astaxanthin and preparation method thereof - Google Patents

Drop pill containing astaxanthin and preparation method thereof Download PDF

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Publication number
CN114403443A
CN114403443A CN202210131314.XA CN202210131314A CN114403443A CN 114403443 A CN114403443 A CN 114403443A CN 202210131314 A CN202210131314 A CN 202210131314A CN 114403443 A CN114403443 A CN 114403443A
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Prior art keywords
astaxanthin
parts
pill
dripping
dropping
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CN202210131314.XA
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Chinese (zh)
Inventor
高慧
李春华
李忠友
李星欣
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Yunnan Aierkang Biotechnology Co ltd
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Yunnan Aierkang Biotechnology Co ltd
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Priority to CN202210131314.XA priority Critical patent/CN114403443A/en
Publication of CN114403443A publication Critical patent/CN114403443A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a dropping pill containing astaxanthin and a preparation method thereof, which comprises the following components in parts by weight: 2-11 parts of astaxanthin, 2-8 parts of beta-nicotinamide mononucleotide, 40-80 parts of water-soluble matrix, 0.04-0.2 part of sweetening agent, 2-20 parts of functional sugar alcohol, 3-15 parts of fruits and vegetables, 0.05-0.5 part of antioxidant, 0-3.0 parts of essence, 0.1-1.0 part of sour agent and 0.05-0.5 part of acid-base balance regulator. The drop pill prepared by the invention has stable performance, convenient carrying and pure and beautiful taste, can still keep the original astaxanthin efficacy, and has the biological efficacy of resisting oxidation, improving immunity, delaying senescence and inhibiting free radicals.

Description

Drop pill containing astaxanthin and preparation method thereof
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a dropping pill containing astaxanthin and a preparation method thereof.
Background
Astaxanthin, also known as astaxanthin or astaxanthin, is a carotenoid and a strong natural antioxidant. Astaxanthin, like other carotenoids, is a fat-soluble and water-soluble pigment, and has a strong antioxidant capacity 550 times that of vitamin E and 10 times that of beta-carotene. The molecular structure of the astaxanthin contains 13 conjugated double bonds, hydroxyl and unsaturated ketone groups existing on a terminal ring structure and alpha-hydroxyketone consisting of the hydroxyl and the ketone groups, the multiple unsaturated double bond structure of the astaxanthin determines that the astaxanthin is easy to degrade and oxidize under the action of light, oxygen and heat, and meanwhile, the astaxanthin extracted from haematococcus pluvialis exists in the form of ester, the content of the astaxanthin accounts for about 5 percent of that of astaxanthin oil, so that the astaxanthin cannot be directly applied to an aqueous environment, and the utilization rate of the astaxanthin is reduced.
The drop pill is a pellet preparation prepared by heating, melting and mixing solid or liquid medicine and appropriate substance (generally called matrix), dripping into immiscible condensate, and shrinking and condensing. The preparation method of the dripping pill has the advantages of simple equipment, convenient operation, contribution to labor protection, short process period, high productivity, easily controlled process conditions, stable quality, accurate dosage, short heating time, easy oxidation and increased stability after the volatile medicine is dissolved in the matrix. However, the pill has small drug-loading rate, low corresponding drug content and large dosage, and simultaneously, the selected matrix and condensing agent are less, so that the variety of the pill is limited, and not all effective components can be prepared into the pill.
In recent years, studies have been made to investigate the effect of storage and processing conditions on the stability of astaxanthin, confirming that the stability and bioavailability of astaxanthin can be improved by controlling the processing and formulation conditions. The existing astaxanthin preparation formulation comprises a soft capsule, a dispersing agent, micro/nano particles and an emulsifying agent. However, no relevant report is found in the research of preparing astaxanthin into the dropping pill.
Disclosure of Invention
The invention aims to provide an astaxanthin dropping pill which has stable performance, convenient carrying and pure and beautiful taste, can still keep the original astaxanthin efficacy, and has the biological efficacies of resisting oxidation, improving immunity, delaying senility and inhibiting free radicals.
In order to solve the technical problems, the invention provides the following technical scheme:
the invention provides an astaxanthin dripping pill which comprises the following components in parts by weight: 2-11 parts of astaxanthin, 2-8 parts of beta-nicotinamide mononucleotide, 40-80 parts of water-soluble matrix, 0.04-0.2 part of sweetening agent, 2-20 parts of functional sugar alcohol, 3-15 parts of fruits and vegetables, 0.05-0.5 part of antioxidant, 0-3.0 parts of essence, 0.1-1.0 part of sour agent and 0.05-0.5 part of acid-base balance regulator.
Preferably, the astaxanthin is one or two of astaxanthin microcapsule powder and haematococcus pluvialis powder.
Preferably, the water-soluble matrix comprises one or more of PEG4000, PEG6000, sodium stearate, water and glycerol.
Preferably, the functional sugar alcohol comprises one or more of erythritol, xylitol, mannitol, maltitol and sorbitol.
Preferably, the acid-base balance regulator comprises one or more of sodium chloride, sodium citrate, potassium chloride and potassium citrate.
The invention provides a preparation method of an astaxanthin dripping pill, which comprises the following steps:
(1) pouring astaxanthin, beta-nicotinamide mononucleotide, sweetener, functional sugar alcohol, fruits and vegetables, antioxidant, essence, acidity regulator and acid-base balance regulator into water-soluble matrix, heating and stirring to obtain dripping pill;
(2) dripping the dropping liquid of the dropping pill into liquid paraffin to obtain the astaxanthin dropping pill.
Preferably, the dropping height in the step (2) is 5-20 cm.
Preferably, the dropping temperature in the step (2) is 70-100 ℃.
Preferably, the inner diameter of the dropping pipe for dropping in the step (2) is 1.0-2.0 mm, and the outer diameter is 2.0-4.0 mm.
Preferably, the liquid paraffin in step (2) is cooled by an ice water bath.
Compared with the prior art, the invention has the following beneficial effects:
the astaxanthin is prepared into the dropping pill for the first time, and the prepared dropping pill has stable performance, convenient carrying, pure and beautiful taste, small health and safety risk and easy storage; can still maintain the original astaxanthin efficacy, and has biological effects of resisting oxidation, improving immunity, delaying aging, and inhibiting free radicals.
The astaxanthin dropping pill prepared by the method has the advantages of simple process, no dust, low production cost and good industrial practicability.
Drawings
Figure 1 is a flow chart of the preparation of astaxanthin dropping pills.
Detailed Description
The invention provides an astaxanthin dripping pill which is characterized by comprising the following components in parts by weight: 2-11 parts of astaxanthin, 2-8 parts of beta-nicotinamide mononucleotide, 40-80 parts of water-soluble matrix, 0.04-0.2 part of sweetening agent, 2-20 parts of functional sugar alcohol, 3-15 parts of fruits and vegetables, 0.05-0.5 part of antioxidant, 0-3.0 parts of essence, 0.1-1.0 part of sour agent and 0.05-0.5 part of acid-base balance regulator. The sources of the components are not particularly limited in the present invention, and commercially available products known to those skilled in the art may be used.
In the present invention, the astaxanthin is preferably 3 to 11 parts by weight, and more preferably 10 parts by weight. The astaxanthin is preferably astaxanthin microcapsule powder or one or two of astaxanthin microcapsule powder and haematococcus pluvialis powder, and is more preferably astaxanthin microcapsule powder. In the invention, the haematococcus pluvialis powder is haematococcus pluvialis wall-broken powder.
In the invention, the weight part of the beta-nicotinamide mononucleotide is preferably 3-5 parts, and more preferably 4.25 parts. The beta-nicotinamide mononucleotide of the invention has the functions of delaying senility, promoting blood flow and heart health, preventing neurological diseases and resisting obesity and diabetes.
In the present invention, the water-soluble base is preferably 65 to 75 parts by weight, and more preferably 72.12 parts by weight. In the invention, the water-soluble matrix is preferably one or more of PEG4000, PEG6000, sodium stearate, water and glycerol, and more preferably PEG6000, water and glycerol. As an embodiment, when the water-soluble matrix is PEG6000, water and glycerin, the PEG6000 is preferably 61.43 parts by weight, the water is preferably 4.58 parts by weight, and the glycerin is preferably 6.11 parts by weight.
In the present invention, the weight part of the sweetener is preferably 0.05 to 0.1 part, and more preferably 0.09 part. The sweetening agent in the invention is preferably one or more of acesulfame potassium, saccharin sodium, mogroside, neotame, aspartame, stevioside and sucralose, and is more preferably sucralose.
In the present invention, the weight part of the functional sugar alcohol is preferably 6 to 15 parts, and more preferably 11.04 parts. In the present invention, the functional sugar alcohol is preferably one or more of erythritol, xylitol, mannitol, maltitol, and sorbitol, and more preferably two of erythritol and xylitol. As an embodiment, when the functional sugar alcohols are erythritol and xylitol, the weight part of erythritol is preferably 2 to 10 parts, more preferably 4.25 parts, and the weight part of xylitol is preferably 2 to 10 parts, more preferably 6.79 parts. The functional sugar alcohol has low heat, does not stimulate insulin secretion, does not cause blood sugar rise and obesity, and can prevent dental caries.
In the invention, the weight part of the fruits and vegetables is preferably 5-10 parts, and more preferably 8.49 parts. The fruit and vegetable of the invention is preferably one or more of fruit and vegetable powder, fruit and vegetable juice and fruit and vegetable extract, and more preferably fruit and vegetable powder. As an implementation mode, the fruits and vegetables are coconut milk raw powder, and the weight part of the coconut milk raw powder is 8.49 parts.
In the invention, the antioxidant is preferably 0.08-0.3 part by weight, and more preferably 0.1 part by weight. In the invention, the antioxidant is preferably one or more of vitamin C, tea polyphenol, vitamin E, bamboo leaf antioxidant, licorice antioxidant, rosemary extract, green tea extract and carotenoid, and more preferably vitamin C. As an embodiment, the vitamin C is 0.1 part by weight.
In the invention, the essence is preferably 0.2-2.5 parts by weight, and more preferably 0.5 part by weight. The essence is preferably natural plant essence.
In the invention, the weight part of the sour agent is preferably 0.2-0.8 part, and more preferably 0.4 part. In the present invention, the acidulant is preferably one or more of citric acid, lactic acid, tartaric acid, acetic acid, malic acid, and gluconic acid, and more preferably citric acid. As an embodiment, the citric acid is 0.4 parts by weight.
In the invention, the weight part of the acid-base balance regulator is preferably 0.08-0.3 part, and more preferably 0.1 part. The acid-base balance regulator in the invention is preferably one or more of sodium chloride, sodium citrate, potassium chloride and potassium citrate, and more preferably sodium citrate. As one possible embodiment, the sodium citrate is 0.1 part by weight.
The invention provides a preparation method of the astaxanthin dropping pill, which comprises the following steps:
(1) pouring astaxanthin, beta-nicotinamide mononucleotide, sweetener, functional sugar alcohol, fruits and vegetables, antioxidant, essence, acidity regulator and acid-base balance regulator into water-soluble matrix, heating and stirring to obtain dripping pill;
(2) dripping the dropping liquid of the dropping pill into cooled liquid paraffin to obtain the astaxanthin dropping pill.
In the present invention, the water-soluble matrix is preferably three of PEG6000, water and glycerin. As an implementation mode, the PEG6000 needs to be melted at high temperature, the melted PEG6000 is uniformly mixed with the astaxanthin, the beta-nicotinamide mononucleotide, the sweetener, the functional sugar alcohols, the fruits and vegetables, the antioxidant, the essence, the sour agent and the acid-base balance regulator to ensure that all the components are completely melted, and then water and glycerol are added to be heated and uniformly mixed.
In the invention, the melting temperature is 90-100 ℃.
The dripping temperature of the dripping pill is preferably 70-100 ℃, and more preferably 70-85 ℃; the preferred dripping height is 5-20 cm, and the more preferred dripping height is 10-15 cm; the inner diameter of the dripping pipe for dripping is 1.0-2.0 mm, more preferably 1.5mm, and the outer diameter is 2.0-4.0 mm, more preferably 3.0 mm; the dripping height is the distance between the dropper and the liquid paraffin horizontal plane. In the invention, the constant temperature and the hydrostatic pressure of the dropping liquid are kept constant in the dropping process. In the invention, proper dropping temperature, dropping height and inner and outer diameters of a dropper used for dropping are set, so that dropping pills with uniform particle weight and particle size and good smoothness and roundness can be obtained, and the original activity of astaxanthin can be maintained.
In the present invention, the temperature of the liquid paraffin is preferably cooled by ice-water bath. The dropping pill prepared by the invention can slowly float upwards or sink in the liquid paraffin, so that the prepared dropping pill is well formed.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
The astaxanthin dropping pill of the embodiment comprises the following components in parts by weight:
10 parts of astaxanthin microcapsule powder, 600061.43 parts of PEG, 0.09 part of sucralose, 4.25 parts of erythritol, 6.79 parts of xylitol, 8.49 parts of coconut milk raw powder, 4.25 parts of beta-nicotinamide mononucleotide, 0.4 part of citric acid, 0.1 part of sodium citrate, 0.1 part of vitamin C, 4.58 parts of water and 6.11 parts of glycerol.
The preparation method of the astaxanthin dropping pill comprises the following steps:
(1) heating the PEG6000 in parts by weight in an oven or a water bath kettle to 95 ℃ to melt the PEG6000 to obtain molten PEG 6000;
(2) uniformly mixing the astaxanthin microcapsule powder, beta-nicotinamide mononucleotide, sucralose, erythritol, xylitol, coconut milk raw powder, citric acid, sodium citrate and vitamin C in parts by weight, pouring the mixture into molten PEG6000, and uniformly stirring at 70-85 ℃ to melt the mixture to obtain dropping pills;
(3) placing the beaker filled with the liquid paraffin in a cold water basin containing an ice bag to obtain cooled liquid paraffin;
(4) dripping the dripping pill into cooled liquid paraffin with a dropper with inner diameter of 1.5mm and outer diameter of 3.0mm, maintaining the temperature of the dropper mouth at 70 deg.C and the height of the dropper at 15cm to obtain astaxanthin dripping pill.
Example 2
The astaxanthin dropping pill of the embodiment comprises the following components in parts by weight:
4.25 parts of astaxanthin microcapsule powder, 600070.24 parts of PEG, 0.1 part of sucralose, 4.25 parts of erythritol, 6.79 parts of xylitol, 6.74 parts of coconut milk raw powder, 5 parts of beta-nicotinamide mononucleotide, 0.2 part of citric acid, 0.1 part of sodium citrate, 0.2 part of vitamin C, 2.74 parts of water and 5.36 parts of glycerol.
The preparation method of the astaxanthin dropping pill in the embodiment is different from the embodiment 1 in that the heating temperature in the step (1) is 100 ℃, the dropper mouth temperature in the step (4) is 65 ℃, and the dropper height is 12 cm; the other steps were the same as in example 1.
Example 3
The astaxanthin dropping pill of the embodiment comprises the following components in parts by weight:
7.5 parts of haematococcus pluvialis wall-breaking powder, 600065.21 parts of PEG, 0.2 part of sucralose, 3.27 parts of erythritol, 14.23 parts of xylitol, 5.48 parts of coconut milk raw powder, 3.78 parts of beta-nicotinamide mononucleotide, 0.6 part of citric acid, 0.4 part of sodium citrate, 0.2 part of vitamin C, 2 parts of water and 4.5 parts of glycerol.
The preparation method of the astaxanthin dropping pill of the embodiment is different from the embodiment 1 in that the heating temperature in the step (1) is 90 ℃, the dropper mouth temperature in the step (4) is 75 ℃, the dropper height is 18cm, and other steps are the same as the embodiment 1.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. An astaxanthin dripping pill is characterized by comprising the following components in parts by weight: 2-11 parts of astaxanthin, 2-8 parts of beta-nicotinamide mononucleotide, 40-80 parts of water-soluble matrix, 0.04-0.2 part of sweetening agent, 2-20 parts of functional sugar alcohol, 3-15 parts of fruits and vegetables, 0.05-0.5 part of antioxidant, 0-3.0 parts of essence, 0.1-1.0 part of sour agent and 0.05-0.5 part of acid-base balance regulator.
2. The astaxanthin drop pill of claim 1, wherein the astaxanthin is one or both of astaxanthin microcapsule powder and haematococcus pluvialis powder.
3. The astaxanthin drop pill of claim 1, wherein the water soluble matrix comprises one or more of PEG4000, PEG6000, sodium stearate, water, glycerol.
4. The astaxanthin drop pill of claim 1, wherein the functional sugar alcohol comprises one or more of erythritol, xylitol, mannitol, maltitol, and sorbitol.
5. The astaxanthin drop pill of claim 1, wherein the acid-base balance regulator comprises one or more of sodium chloride, sodium citrate, potassium chloride and potassium citrate.
6. The method for preparing an astaxanthin dripping pill according to any one of claims 1 to 5, comprising the following steps:
(1) pouring astaxanthin, beta-nicotinamide mononucleotide, sweetener, functional sugar alcohol, fruits and vegetables, antioxidant, essence, acidity regulator and acid-base balance regulator into water-soluble matrix, heating and stirring to obtain dripping pill;
(2) dripping the dropping liquid of the dropping pill into liquid paraffin to obtain the astaxanthin dropping pill.
7. The method for preparing an astaxanthin dripping pill according to claim 6, wherein the dripping height in the step (2) is 5-20 cm.
8. The method for preparing an astaxanthin dripping pill according to claim 6, wherein the dripping temperature in the step (2) is 70-100 ℃.
9. The method for producing an astaxanthin dropping pill according to claim 6, wherein the inner diameter of the dropping pill for dropping in the step (2) is 1.0 to 2.0mm, and the outer diameter thereof is 2.0 to 4.0 mm.
10. The method for preparing an astaxanthin dripping pill according to claim 6, wherein the liquid paraffin in the step (2) is cooled in an ice-water bath.
CN202210131314.XA 2022-02-14 2022-02-14 Drop pill containing astaxanthin and preparation method thereof Pending CN114403443A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105725184A (en) * 2016-02-02 2016-07-06 北京同仁堂健康药业股份有限公司 Composition containing haematococcus pluvialis and collagen and preparing method thereof
CN107753445A (en) * 2016-08-18 2018-03-06 江苏康缘药业股份有限公司 A kind of bilobalide K dripping pill and preparation method thereof
CN111888464A (en) * 2020-08-06 2020-11-06 朱洪滨 A health composition with antiaging and immunity enhancing effects
CN112515070A (en) * 2020-11-11 2021-03-19 云南爱尔康生物技术有限公司 Sports beverage containing astaxanthin, taurine, nicotinamide mononucleotide and electrolyte and preparation method thereof
CN113262237A (en) * 2021-06-09 2021-08-17 云南维他源生物科技有限公司 AGNM composition, preparation and application thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105725184A (en) * 2016-02-02 2016-07-06 北京同仁堂健康药业股份有限公司 Composition containing haematococcus pluvialis and collagen and preparing method thereof
CN107753445A (en) * 2016-08-18 2018-03-06 江苏康缘药业股份有限公司 A kind of bilobalide K dripping pill and preparation method thereof
CN111888464A (en) * 2020-08-06 2020-11-06 朱洪滨 A health composition with antiaging and immunity enhancing effects
CN112515070A (en) * 2020-11-11 2021-03-19 云南爱尔康生物技术有限公司 Sports beverage containing astaxanthin, taurine, nicotinamide mononucleotide and electrolyte and preparation method thereof
CN113262237A (en) * 2021-06-09 2021-08-17 云南维他源生物科技有限公司 AGNM composition, preparation and application thereof

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