CN114388335A - Mass spectrum data acquisition device and method based on multichannel technology - Google Patents
Mass spectrum data acquisition device and method based on multichannel technology Download PDFInfo
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- CN114388335A CN114388335A CN202111660029.9A CN202111660029A CN114388335A CN 114388335 A CN114388335 A CN 114388335A CN 202111660029 A CN202111660029 A CN 202111660029A CN 114388335 A CN114388335 A CN 114388335A
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- 238000005516 engineering process Methods 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000001819 mass spectrum Methods 0.000 title claims abstract description 16
- 150000002500 ions Chemical class 0.000 claims abstract description 124
- 238000013507 mapping Methods 0.000 claims abstract description 26
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 238000004364 calculation method Methods 0.000 claims abstract description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 9
- 238000001514 detection method Methods 0.000 description 6
- 230000001846 repelling effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001196 time-of-flight mass spectrum Methods 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/025—Detectors specially adapted to particle spectrometers
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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Abstract
The invention provides a mass spectrum data acquisition device and a method based on a multichannel technology, wherein the mass spectrum data acquisition device based on the multichannel technology comprises a repulsion electrode and a first detector; further comprising: the first detector and the second detector are arranged in sequence, and the tolerance degree to the ionic strength is gradually improved; the calculating unit is used for respectively outputting ions with the same intensity on the first detector and the second detector to obtain a first mapping relation of conversion between the intensities of the ions output by the first detector and the second detector; and converting the output ion intensity of the second detector according to the first mapping relationship; the memory is used for storing the mapping relation; the control unit is used for adjusting the repulsion voltage so that the incident ions are deflected to a selected detector; the output unit is used for obtaining the ion intensity and the flight time according to the conversion results output by the first detector and the calculation unit. The invention has the advantages of long service life and the like.
Description
Technical Field
The invention relates to mass spectrometry, in particular to a mass spectrometry data acquisition device and method based on a multichannel technology.
Background
Time of Flight Mass Spectrometer (TOFMS) is a commonly used Mass Spectrometer with the technical principle: the ions with different mass-to-charge ratios are given the same initial kinetic energy, the ions reach the detector through the same flight path, and the ions with different mass-to-charge ratios are distinguished according to different arrival times, so that qualitative and quantitative analysis of the substances is completed. High gain microchannel plates are typically used as detectors in time-of-flight mass spectrometers. However, the characteristics of the time-of-flight full spectrum analysis lead to that if the microchannel plate is impacted by high-intensity ion flow for a long time in the using process, the performance is easy to be attenuated, and the service life is greatly shortened.
In order to solve the above problems, the following technical solutions are generally adopted:
1. before the ions enter the time-of-flight mass spectrum, high-intensity ions are filtered by utilizing quadrupole rod transmission;
2. applying pulses to the grid at the front end of the detector removes unwanted ions before they reach the microchannel plate
3. Mass spectrometry detection by applying pulsed voltages to the outer sector housing of a sector energy analyzer to screen out or select portions of ions to eliminate interfering ion effects
In the above mentioned schemes, high-intensity ions are filtered in different ways to reduce the damage to the microchannel plate detector. But with the consequent drawbacks: these approaches can result in loss of filtered ion information and failure to acquire full spectral data.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a mass spectrum data acquisition device based on a multichannel technology.
The purpose of the invention is realized by the following technical scheme:
the mass spectrum data acquisition device based on the multichannel technology comprises a repulsion electrode and a first detector; the mass spectrum data acquisition device based on the multichannel technology further comprises:
the first detector and the second detector are arranged in sequence, and the tolerance degree of the first detector and the second detector to the ionic strength is gradually improved;
the calculating unit is used for respectively outputting ions with the same intensity on the first detector and the second detector to obtain a first mapping relation of conversion between the intensities of the ions output by the first detector and the second detector; and converting the output ion intensity of the second detector according to the first mapping relationship;
a memory for storing the mapping relationship;
a control unit for adjusting the repeller voltage such that incident ions are deflected to a selected detector;
and the output unit is used for obtaining the ion intensity and the flight time according to the conversion results output by the first detector and the calculation unit.
The invention also aims to provide a mass spectrum data acquisition method based on the multichannel technology, and the aim of the invention is realized by the following technical scheme:
the mass spectrum data acquisition method based on the multichannel technology comprises the following steps:
(A1) the ions enter a first detector, and ion intensity information and flight time are output;
(A2) dividing intensity intervals according to the intensity distribution in the ion intensity information, wherein each intensity interval corresponds to a detector, and the higher the ion intensity is, the higher the tolerance degree of the corresponding detector to the ion intensity is, so as to obtain the corresponding relation between the ions and the detectors as well as the flight time;
(A3) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A4) obtaining and storing a mapping relation of conversion among detector outputs according to the ion intensities respectively output by the same-intensity ions at different detectors;
(A5) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A6) converting the ion intensity output by each detector according to the mapping relation;
(A7) output ion intensity and time of flight.
Compared with the prior art, the invention has the beneficial effects that:
1. the service life is long;
ions are subjected to secondary separation by using different flight times, so that the ions with different intensities enter suitable detection channels (each detector has different tolerance degrees on the ion intensity) for detection, the damage of high-intensity ions to the MCP detector is avoided, the service life is prolonged, and meanwhile, full-spectrum data can be obtained;
2. the obtained data are accurate;
a two-stage pre-scanning and formal scanning mode is adopted, so that the problem of inconsistent response of different detectors (detection channels) is solved, and the accuracy of data acquisition is improved;
3. the data is comprehensive;
the multi-channel detection mode of (a plurality of detectors) is adopted, the problem that an MCP detector cannot detect supersaturated ions is avoided, and the dynamic range of ion detection is widened.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:
fig. 1 is a schematic flow chart of a mass spectrometry data acquisition method based on a multichannel technique according to an embodiment of the present invention.
Detailed Description
Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. Some conventional aspects have been simplified or omitted for the purpose of explaining the technical solution of the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
the mass spectrum data acquisition device based on the multichannel technology comprises the following components:
a repeller and a first detector;
the first detector and the second detector are arranged in sequence, and the tolerance degree of the second detector to the ion intensity is gradually improved, namely the tolerance degree of the second detector to the ion intensity is higher than that of the first detector;
the calculating unit is used for respectively outputting ions with the same intensity on the first detector and the second detector to obtain a first mapping relation of conversion between the intensities of the ions output by the first detector and the second detector; and converting the output ion intensity of the second detector according to the first mapping relationship;
a memory for storing the mapping relationship;
a control unit for adjusting the repeller voltage such that incident ions are deflected to a selected detector;
and the output unit is used for obtaining the ion intensity and the flight time according to the conversion results output by the first detector and the calculation unit.
In order to adapt to the receiving of ions with different intensities, further, the mass spectrum data acquisition device further comprises:
the first detector, the second detector and the third detector are arranged in sequence, and the tolerance degree of the third detector to the ion intensity is gradually improved;
the computing unit is used for respectively outputting ions with the same intensity on the first detector, the second detector and the third detector to obtain a second mapping relation of conversion between the ion intensities output by the first detector and the third detector and sending the second mapping relation to the memory for storage; and converting the output ion intensity of the third detector according to the second mapping relationship;
the output unit is used for obtaining the ion intensity according to the conversion results output by the first detector and the calculation unit.
As shown in fig. 1, the method for acquiring mass spectrum data based on multichannel technology includes the following steps:
(A1) the ions enter a first detector, and ion intensity information and flight time are output;
(A2) dividing intensity intervals according to the intensity distribution in the ion intensity information, wherein each intensity interval corresponds to a detector, and the higher the ion intensity is, the higher the tolerance degree of the corresponding detector to the ion intensity is, so as to obtain the corresponding relation between the ions and the detectors as well as the flight time;
(A3) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A4) obtaining and storing a mapping relation of conversion among detector outputs according to the ion intensities respectively output by the same-intensity ions at different detectors;
(A5) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A6) converting the ion intensity output by each detector according to the mapping relation;
(A7) output ion intensity and time of flight.
In order to reduce the complexity of the structure and the difficulty of operation, furthermore, along the arrangement direction of each detector, the tolerance of the detector to the ion intensity is gradually improved.
Example 2:
the application example of the mass spectrum data acquisition device and method based on the multichannel technology in the embodiment 1 of the invention is disclosed.
In this application, the first detector is a microchannel plate detector, the second detector is a faraday cup, the third detector is a charge receiving plate, and the individual detectors are arranged in series.
As shown in fig. 1, the method for acquiring mass spectrometry data based on a multichannel technique, that is, the working method of the mass spectrometry data acquisition device of this embodiment, includes the following steps:
(A1) pre-scanning 1, enabling ions to enter a first detector, and outputting ion intensity information and flight time;
(A2) dividing intensity intervals according to the intensity distribution in the ion intensity information: the intensity is lower than 10000 and is a low intensity interval, 10000 to 20000 are medium intensity intervals, and more than 20000 are high intensity intervals; each intensity interval corresponds to a detector, the higher the ion intensity is, the higher the tolerance degree of the corresponding detector to the ion intensity is, the lower intensity interval corresponds to a microchannel plate detector, the middle intensity interval corresponds to a Faraday cup, and the higher intensity interval corresponds to a charge receiving plate, so that the corresponding relation between ions and the detector and the flight time is obtained;
(A3) pre-scanning 2, enabling ions to enter, and according to the corresponding relation, repelling the ions to a detector corresponding to the ions, and obtaining the output ion intensity of the detector;
(A4) obtaining and storing a mapping relation, usually a linear relation, of conversion between detector outputs according to the ion intensities respectively output by different detectors of ions with the same intensity;
(A5) formal scanning, namely, enabling ions to enter, and according to the corresponding relation, repelling the ions to a detector corresponding to the ions and obtaining the output ion intensity of the detector;
(A6) converting the ion intensity output by each detector according to the mapping relation;
(A7) output ion intensity and time of flight.
Claims (6)
1. The mass spectrum data acquisition device based on the multichannel technology comprises a repulsion electrode and a first detector; it is characterized in that the mass spectrum data acquisition device based on the multichannel technology further comprises:
the first detector and the second detector are arranged in sequence, and the tolerance degree of the first detector and the second detector to the ionic strength is gradually improved;
the calculating unit is used for respectively outputting ions with the same intensity on the first detector and the second detector to obtain a first mapping relation of conversion between the intensities of the ions output by the first detector and the second detector; and converting the output ion intensity of the second detector according to the first mapping relationship;
a memory for storing the mapping relationship;
a control unit for adjusting the repeller voltage such that incident ions are deflected to a selected detector;
and the output unit is used for obtaining the ion intensity and the flight time according to the conversion results output by the first detector and the calculation unit.
2. The mass spectrometry data acquisition device based on multichannel technology as claimed in claim 1, characterized in that the mass spectrometry data acquisition device further comprises:
the first detector, the second detector and the third detector are arranged in sequence, and the tolerance degree of the third detector to the ion intensity is gradually improved;
the computing unit is used for respectively outputting ions with the same intensity on the first detector, the second detector and the third detector to obtain a second mapping relation of conversion between the ion intensities output by the first detector and the third detector and sending the second mapping relation to the memory for storage; and converting the output ion intensity of the third detector according to the second mapping relationship;
the output unit is used for obtaining the ion intensity according to the conversion results output by the first detector and the calculation unit.
3. The multichannel-technology-based mass spectrometry data acquisition device of claim 2, wherein the first detector is a microchannel plate detector, the second detector is a faraday cup, and the third detector is a charge receiving plate.
4. The mass spectrum data acquisition method based on the multichannel technology comprises the following steps:
(A1) the ions enter a first detector, and ion intensity information and flight time are output;
(A2) dividing intensity intervals according to the intensity distribution in the ion intensity information, wherein each intensity interval corresponds to a detector, and the higher the ion intensity is, the higher the tolerance degree of the corresponding detector to the ion intensity is, so as to obtain the corresponding relation between the ions and the detectors as well as the flight time;
(A3) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A4) obtaining and storing a mapping relation of conversion among detector outputs according to the ion intensities respectively output by the same-intensity ions at different detectors;
(A5) the ions are incident, and according to the corresponding relation, the ions are repelled to the detector corresponding to the ions, and the output ion intensity of the detector is obtained;
(A6) converting the ion intensity output by each detector according to the mapping relation;
(A7) output ion intensity and time of flight.
5. The method of claim 4, wherein the detectors are more tolerant to ion intensities along the direction of alignment of the detectors.
6. The method of claim 5, wherein each detector comprises a first detector, a Faraday cup and a charge-receiving plate arranged in sequence, and the first detector is a microchannel plate detector.
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| CN202111660029.9A CN114388335A (en) | 2021-12-30 | 2021-12-30 | Mass spectrum data acquisition device and method based on multichannel technology |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040222374A1 (en) * | 2003-05-07 | 2004-11-11 | Scheidemann Adi A. | Ion detector array assembly and devices comprising the same |
| JP2005302622A (en) * | 2004-04-15 | 2005-10-27 | Hitachi High-Technologies Corp | Time-of-flight type mass spectrometer, and method of mass spectrometry |
| JP2008282571A (en) * | 2007-05-08 | 2008-11-20 | Shimadzu Corp | Time-of-flight mass spectrometer |
| US20120112060A1 (en) * | 2010-11-05 | 2012-05-10 | Shimadzu Corporation | Multi-Turn Time-of-Flight Mass Spectrometer |
| US20120305760A1 (en) * | 2011-06-02 | 2012-12-06 | Robert Blick | Membrane Detector for Time-of-Flight Mass Spectrometry |
| US20190189418A1 (en) * | 2017-12-20 | 2019-06-20 | Shimadzu Corporation | Ion analyzer |
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2021
- 2021-12-30 CN CN202111660029.9A patent/CN114388335A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040222374A1 (en) * | 2003-05-07 | 2004-11-11 | Scheidemann Adi A. | Ion detector array assembly and devices comprising the same |
| JP2005302622A (en) * | 2004-04-15 | 2005-10-27 | Hitachi High-Technologies Corp | Time-of-flight type mass spectrometer, and method of mass spectrometry |
| JP2008282571A (en) * | 2007-05-08 | 2008-11-20 | Shimadzu Corp | Time-of-flight mass spectrometer |
| US20120112060A1 (en) * | 2010-11-05 | 2012-05-10 | Shimadzu Corporation | Multi-Turn Time-of-Flight Mass Spectrometer |
| US20120305760A1 (en) * | 2011-06-02 | 2012-12-06 | Robert Blick | Membrane Detector for Time-of-Flight Mass Spectrometry |
| US20190189418A1 (en) * | 2017-12-20 | 2019-06-20 | Shimadzu Corporation | Ion analyzer |
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