CN114367322A - Freeze-drying preparation based on quantitative liquid transfer device - Google Patents
Freeze-drying preparation based on quantitative liquid transfer device Download PDFInfo
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- CN114367322A CN114367322A CN202110104382.2A CN202110104382A CN114367322A CN 114367322 A CN114367322 A CN 114367322A CN 202110104382 A CN202110104382 A CN 202110104382A CN 114367322 A CN114367322 A CN 114367322A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
Abstract
The invention provides a freeze-dried preparation based on a quantitative liquid transfer device, which comprises the quantitative liquid transfer device capable of sucking and discharging a dissolving solution quantitatively or a packaging device packaged with the freeze-dried preparation; the dissolving solution is packaged in the quantitative liquid-transfering device, or is packaged in a packaged product separately, or is packaged in the packaging device separately from the freeze-dried preparation. The invention can realize that the quantitative dissolving solution is used for dissolving the freeze-dried preparation, the operation is convenient and fast, and the use effect of the freeze-dried preparation is optimized.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a freeze-dried preparation based on a quantitative liquid transfer device.
Background
The freeze-dried preparation is a new cosmetic, because the freeze-dried preparation does not contain antiseptic components, has small irritation to skin and is favored by wide consumers, in the existing commercial freeze-dried preparation, the freeze-dried preparation is packaged in a bubble cap or a packaging bag, when the freeze-dried preparation is used, the freeze-dried preparation is taken out and placed on a cosmetic cotton, and is matched with cosmetic water or purified water, after the freeze-dried preparation is completely dissolved, the freeze-dried preparation is applied to the face for use, when the freeze-dried preparation is used by the method, the cosmetic water or the purified water cannot be quantified, when the water is too much, the concentration of the product after the dissolution is low, when the water is too little, part of the product cannot be completely dissolved, and therefore, the performance of the freeze-dried preparation cannot reach the optimal state.
Disclosure of Invention
The invention aims to provide a freeze-dried preparation based on a quantitative liquid transfer device, aiming at the problem that the use of the freeze-dried preparation in the prior art is inconvenient to control the amount of a dissolving solution for dissolving.
The technical scheme adopted for realizing the purpose of the invention is as follows:
a freeze-dried preparation based on a quantitative liquid-transfering device comprises a quantitative liquid-transfering device which can suck and eject a dissolving solution quantitatively, or a packaging device which is also packaged with the freeze-dried preparation;
the dissolving solution is packaged in the quantitative liquid-transfering device, or is packaged in a packaged product separately, or is packaged in the packaging device separately from the freeze-dried preparation.
In the above technical solution, the quantitative liquid-transfering device is a dropper bottle, a quantitative squeeze bottle, a press pump bottle or a liquid-transfering gun.
In the technical scheme, the packaging device packaged with the freeze-drying preparation is in a spherical, annular, tubular, heart-shaped, star-shaped, prismatic, conical or cartoon shape provided with a liquid inlet and a vent valve.
In the above technical scheme, the liquid outlet of the quantitative liquid-transfering device can be connected with the liquid inlet of the packaged product or the packaging device in a clamping manner.
In the technical scheme, the quantitative liquid transfer device is a quantitative liquid transfer gun, a dissolved solution storage cavity for packaging dissolved solution and a quantitative mechanism for controlling liquid discharge are arranged in the quantitative liquid transfer gun, a dissolved solution outlet communicated with the dissolved solution storage cavity is formed in the bottom of the quantitative liquid transfer gun, and a detachable sealing end cover is arranged on the dissolved solution outlet;
the packaging device packaged with the freeze-drying preparation is a gun head, a ventilation valve is arranged on the gun head, the dissolved liquid outlet is matched and clamped with a liquid inlet of the gun head, and a sealing piece is arranged on the liquid inlet.
In the above technical solution, the quantitative pipette comprises an outer sleeve and the quantitative mechanism, wherein:
the bottom of the outer sleeve is provided with the solution outlet;
the quantifying mechanism comprises a piston positioned in the outer sleeve and an upper limiting bulge and a lower limiting bulge which are fixed on the inner wall of the outer sleeve, the top of the piston is fixed with a pressing button, a compression spring is arranged between the piston and the lower limiting bulge, and the space at the bottom of the piston is a solution cavity.
In the above technical solution, the structure of the outer sleeve may be a structure with a thick upper part and a thin lower part, or a cylindrical structure, or a structure with a bulge formed in the middle.
In the above technical solution, the sealing member is a sealing cover or a breakable sealing film.
In the technical scheme, a plurality of gun heads are packaged in a packaging box, and the quantitative liquid-transfering gun is additionally packaged or is commonly packaged with the plurality of gun heads;
or the quantitative pipette is clamped and packaged with one gun head, and the other gun heads are independently packaged.
In the technical scheme, the shape of the gun head can be spherical, annular, tubular, heart-shaped, star-shaped, prism-shaped, conical or cartoon-shaped.
In the technical scheme, the quantitative liquid transfer device is not packaged with the dissolving liquid, the dissolving liquid is packaged in a packaging product separately, the packaging product is provided with an opening for the quantitative liquid transfer device to enter for liquid absorption, and the opening is provided with a detachable sealing cover.
In the technical scheme, the packaging product is a packaging bottle, a packaging can or a packaging bag.
In the above technical solution, the quantitative pipetting device includes an outer sleeve, a piston located in the outer sleeve, and a push-off mechanism disposed outside the outer sleeve, wherein:
a suction nozzle structure communicated with the outer sleeve is fixed at the bottom of the outer sleeve, and a detachable suction head is detachably connected to the bottom of the suction nozzle structure;
a pressing button is fixed on the top of the piston, an upper limiting bulge and a lower limiting bulge are fixed on the inner wall of the outer sleeve, and a compression spring is arranged between the piston and the lower limiting bulge;
the push-off mechanism comprises a push-off button and a connecting rod structure fixed at the bottom of the push-off button, the push-off button is connected with the top of the outer sleeve in a sliding manner, and the bottom of the connecting rod structure is in contact with the top of the detachable suction head.
In the above technical solution, the quantitative pipette comprises an outer sleeve and a quantitative mechanism, wherein:
the bottom of the outer sleeve is provided with a solution outlet, and the solution outlet is provided with a detachable sealing end cover;
the quantitative mechanism comprises a piston positioned in the outer sleeve, and an upper limiting bulge and a lower limiting bulge which are fixed on the inner wall of the outer sleeve, wherein the top of the piston is fixed with a pressing button, and a compression spring is arranged between the piston and the lower limiting bulge.
In the technical scheme, the quantitative liquid transfer device is not packaged with a dissolving liquid, the dissolving liquid and the freeze-dried preparation are separately packaged in the packaging device, the packaging device is an intermediate septum gun head, a liquid inlet for the quantitative liquid transfer device to insert and form a clamping is formed in the intermediate septum gun head, a sealing element is arranged on the liquid inlet, a flexible intermediate septum is arranged in the gun head and divides the packaging body into two chambers, and the dissolving liquid and the freeze-dried preparation are respectively packaged in the two chambers.
In the above technical solution, the sealing member is a detachable cover or a sealing cover for the quantitative pipetting device to break and enter.
In the technical scheme, the sealing cover is an aluminum-plastic film;
or the sealing cover is an aluminum cover, and the aluminum cover comprises a rubber plug which is hermetically connected with the liquid inlet and an aluminum layer which is coated outside the rubber plug and the liquid inlet;
or the sealing cover is a sealing aluminum cover and a plastic cover nested on the sealing aluminum cover, and the center of the plastic cover is provided with a hole.
In the technical scheme, the shape of the septal gun head can be spherical, annular, tubular, heart-shaped, star-shaped, prism-shaped, conical or cartoon-shaped and the like.
In the technical scheme, the freeze-dried preparation only comprises a quantitative liquid transferring device which can quantitatively suck and eject the dissolved solution, the quantitative liquid transferring device is a quantitative liquid transferring gun, a dissolved solution storage cavity for packaging the dissolved solution and a quantitative mechanism for controlling liquid discharge are arranged in the quantitative liquid transferring gun, a dissolved solution outlet communicated with the dissolved solution storage cavity is formed in the bottom of the quantitative liquid transferring gun, and a detachable sealing end cover is arranged on the dissolved solution outlet.
In the technical scheme, the packaging device for packaging the freeze-dried preparation comprises a plurality of free insertion units and a hard sealing cover, wherein the hard sealing cover is provided with a vent valve;
each free plug-in unit is internally provided with a packaging cavity for packaging a freeze-dried preparation, the packaging cavity is communicated with circulation ports formed at two ends of the plug-in unit, flexible sealing films are arranged on the circulation ports, when the two plug-in units are plugged, the two packaging cavities are in sealed butt joint, and the hard sealing cover can be plugged in the plug-in unit at the bottommost part to seal the circulation ports hard.
In the above technical scheme, the bottom of the free plugging unit is a convex plugging portion, the top of the free plugging unit is a concave plugging portion matched with the convex plugging portion, the convex plugging portion is provided with a positioning flange, and the concave plugging portion is provided with a positioning groove matched with the positioning flange.
In the technical scheme, the quantitative liquid-transfering device comprises a packaging bottle and a dropper detachably assembled on the packaging bottle, and a port of the dropper can be matched with a liquid inlet of the packaging device so as to realize clamping in a butt joint mode.
In the above technical scheme, the quantitative liquid-transfering device is an extrusion bottle, the end of the extrusion bottle is provided with an extrusion outlet, the extrusion outlet is provided with a detachable sealing cover, the extrusion bottle is a rigid packaging bottle, the bottle body is provided with a flexible pressing part, and the extrusion outlet can be matched with the liquid inlet of the packaging device to realize clamping in a butt joint mode.
In the above technical scheme, the quantitative liquid-transfering device is a pressing bottle, and comprises a pressing bottle body and a pressing pump, wherein the outlet of the pressing pump can be matched with the liquid inlet of the packaging device so as to realize clamping by butt joint.
Compared with the prior art, the invention has the beneficial effects that:
1. the quantitative liquid transfer device realizes the quantification of the dissolving solution for dissolving the freeze-dried preparation, so that the skin care effect of the freeze-dried preparation is optimal, and the effect of precisely caring the skin is achieved.
2. The solution in storage does not contact with the external environment, and the cleanliness is high in the using process.
3. The liquid outlet of the quantitative liquid-transferring device can be connected with the liquid inlet of a packaging product or a packaging device in a clamping mode, single-hand operation is achieved, quantitative output of dissolved liquid can be achieved by pressing a control button of the quantitative liquid-transferring gun, and the quantitative liquid-transferring gun is convenient and fast to use, time-saving and labor-saving.
Drawings
Fig. 1 (a) and (B) are schematic structural views of two kinds of quantitative pipetting devices (without a packaging device) in example 1.1, and (C) is a schematic structural view of a packaging device with a quantitative pipetting device in example 1.2.
FIG. 2 is a schematic view of the structure of the quantitative pipetting device in example 2.2.
FIG. 3 is a schematic view of the structure of the quantitative pipetting device in example 2.3.
Fig. 4 (a) and (B) are schematic illustrations of the construction of two different septal tips of example 3.1.
Fig. 5 is a schematic structural view of the free plug unit in embodiment 4.
Fig. 6 is a schematic structural diagram of the quantitative pipetting device in example 1.2.2, wherein (a) is a schematic structural diagram of a packaging bottle and a dropper, and (B) is a schematic structural diagram of a dropper and a packaging device used in cooperation.
Fig. 7 is a schematic structural diagram of the quantitative pipetting device in example 1.2.3, wherein (a) is a schematic structural diagram of a squeeze bottle, and (B) is a schematic structural diagram of a squeeze bottle and a packaging device in cooperation.
Fig. 8 is a schematic structural diagram of the quantitative pipetting device in example 1.2.4, wherein (a) is a schematic structural diagram of a pressing bottle, and (B) is a schematic structural diagram of a pressing bottle and a packaging device used in cooperation.
FIG. 9 is a schematic view showing the structure of the quantitative pipetting device in example 5 in a state where it is docked with a packaging device of a different configuration.
In the figure: 1-control button, 2-volume adjusting knob, 3-suction head detaching button, 4-volume display window, 5-sleeve, 6-elastic suction nozzle, 7-suction nozzle, 8-outer sleeve, 9-piston, 10-pressing button, 11-upper limiting bulge, 12-lower limiting bulge, 13-suction nozzle structure, 14-connecting rod structure, 15-solution cavity, 16-detachable suction nozzle, 17-sealing end cover, 18-pushing button, 19-gun head, 20-flexible septum, 21-cavity, 22-sealing cover, 23-packaging device, 24-vent valve, 25-free plug-in unit, 26-hard sealing cover, 27-packaging cavity, 28-flow opening, 29-positioning flange, 30-positioning groove, 31-vent valve.
Detailed Description
The invention is described in further detail below with reference to the figures and specific examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
1.1
The utility model provides a freeze-drying preparation based on ration is moved liquid device, is including inhaling, beat out the ration of dissolving the liquid and move liquid device, be equipped with in the ration is moved liquid device and is used for packing the solution storage chamber that dissolves the liquid and be used for controlling the quantitative mechanism who goes out the liquid, ration move liquid device's bottom be equipped with dissolve the solution export that the chamber is linked together with dissolve liquid storage chamber, it is equipped with detachable end cover to dissolve the liquid export.
When the face washing liquid is used every time, the sealing end cover is opened, a one-time quantitative liquid transfer device is pressed to pump out one-time dosage of dissolving liquid, the dissolving liquid is pumped into a package of freeze-dried powder to dissolve the freeze-dried powder, and the dissolving liquid is smeared on the face after being dissolved. A quantitative pipetting device is matched with a plurality of packages with freeze-dried preparations for use, and can dissolve a plurality of freeze-dried preparation products.
Preferably, the freeze-dried preparation is freeze-dried powder, and the dissolving solution is purified water, toning lotion or essence water and is used for dissolving the freeze-dried powder.
Preferably, the dosing pipetting device comprises an outer sleeve 8 and a dosing mechanism, wherein:
the bottom of the outer sleeve 8 is provided with the solution outlet, and the solution outlet is provided with a detachable sealing end cover 17;
the quantitative mechanism comprises a piston 9 positioned in the outer sleeve 8, an upper limit bulge 11 and a lower limit bulge 12 which are fixed on the inner wall of the outer sleeve 8, a press button 10 is fixed at the top of the piston 9, a compression spring is arranged between the piston 9 and the lower limit bulge 12, and a space at the bottom of the piston 9 is a solution cavity 15.
The dissolving solution is filled in the dissolving solution cavity 15, when the dissolving solution is used, the sealing end cover 17 is firstly opened, then the pressing button 10 is pressed once, the piston 9 moves for a distance of one stroke (the distance between the upper limiting bulge 11 and the lower limiting bulge 12), a certain amount of dissolving solution is ejected from a dissolving solution outlet, and when the pressing button 10 is loosened, the piston 9 is reset to be recovered to be used for the next time under the action of the compression spring.
Preferably, the structure of the outer sleeve 8 may be a structure with a thick upper part and a thin lower part, or a cylindrical structure, or a structure with a bulge formed in the middle.
1.2
A pipette-based lyophilized formulation comprising a quantitative pipetting device for aspirating and dispensing a solution as described in example 1.1 and one or more replaceable packaging devices 23 containing lyophilized formulation, the solution outlet mating with a liquid inlet of the packaging device for mating engagement, the liquid inlet being provided with a removable seal.
1.2.1
Preferably, the quantitative liquid transfer device is a quantitative liquid transfer gun, the packaging device 23 is a gun head, and the gun head is provided with a vent valve 24, wherein the vent valve 24 ensures that the dissolving liquid smoothly enters the gun head. The quantitative pipette is matched with one or more gun heads for use.
When the quantitative liquid-transferring gun is used every time, a dissolving liquid outlet of the quantitative liquid-transferring gun is inserted into a gun head, the gun head is driven into the gun head to dissolve the freeze-dried powder in the gun head, and the dissolving liquid obtained by dissolution is poured out from the gun head and is smeared on the face for use. The solution in the storage cavity of each quantitative pipette can be used for dozens of times and matched with dozens of pipette heads.
Preferably, the sealing member is a sealing cover or a breakable sealing film, when the sealing member is the sealing cover, the sealing cover is opened, then the solution outlet of the pipette is inserted into the pipette head, and when the sealing member is the sealing film, the solution outlet of the pipette is directly inserted into the pipette head, the sealing film is punctured, and the solution is injected into the pipette head. Realizing single-hand operation.
In the practical application process, a plurality of rifle heads can be matched with one liquid-transfering gun body, and a plurality of rifle heads are packaged in one packing box, and the liquid-transfering gun body is packaged in addition to realize selling alone, also can pack with a plurality of rifle heads in common for the liquid-transfering gun body, in order to realize supporting sale.
Preferably, the lance tip may be in the shape of a round tube, a prism, a cone, a cartoon figure or the like. The shape of the lance tip does not affect its application.
1.2.2
As shown in fig. 6, the quantitative liquid-transferring device is a packaging bottle and a dropper 32 detachably mounted on the packaging bottle, and the dissolving liquid is packaged in the packaging bottle. The dropper comprises a suction pipe 33 extending into the packaging bottle and a rubber head 34 communicated with the suction pipe, and when the dropper is used each time, the rubber head is squeezed, a certain amount of solution is extracted from the packaging bottle, and then the solution is injected into the packaging device. The port of the dropper can be matched with the liquid inlet of the packaging device 23 to realize butt joint and clamping. The quantitative pipetting device is matched with one or more packaging devices for use.
1.2.3
As shown in fig. 7, the quantitative liquid-transferring device is an extrusion bottle, an extrusion outlet 36 is arranged at the end of the extrusion bottle 35, a detachable sealing cover 37 is arranged on the extrusion outlet, the dissolving solution is packaged in the extrusion bottle, the extrusion bottle is a rigid packaging bottle, and a flexible pressing part 38 is arranged on the bottle body. When the packaging device is used every time, the sealing cover is opened, the packaging device 23 is inserted into the extrusion outlet, the flexible pressing part is pressed, and a certain amount of solution is extruded from the extrusion bottle and enters the packaging device. The extrusion outlet can be matched with the liquid inlet of the packaging device 23 to realize butt joint and clamping. The quantitative pipetting device is matched with one or more packaging devices for use.
1.2.4
As shown in fig. 8, the quantitative liquid-transfering device is a pressing bottle, and includes a pressing bottle body 39 and a pressing pump 40, the outlet of the pressing pump can be matched with the liquid inlet of the packaging device 23 to realize butt joint and clamping, and when the pressing pump is pressed once every time of use, a quantitative dissolving liquid enters into the packaging device. The quantitative pipetting device is matched with one or more packaging devices for use.
Example 2
2.1
The utility model provides a freeze-drying preparation based on ration moves liquid device, includes the ration that can quantitatively inhale, beat out and dissolve the liquid and move liquid device and pack the packing article that has dissolved liquid, wherein the cavity of liquid-moving rifle body is empty, be equipped with the opening that supplies the liquid outlet of ration to move liquid device to get into on the packing article, be equipped with the sealed lid of detachable on the opening.
The dissolving solution is purified water, cosmetic water or essence water.
The packaging product is a packaging bottle, a packaging can or a packaging bag.
Taking a packaging bottle as an example, in each use, a quantitative liquid-transferring device is used for sucking a dose of dissolving liquid from the packaging bottle, and then the dose of dissolving liquid is ejected for dissolving the freeze-dried preparation.
2.2
The quantitative pipetting device of embodiment 2.1 can adopt a prior art laboratory pipette gun, and has the following structure:
gas piston formula pipetting gun includes control button 1, volume adjust knob 2, suction head shirk button 3, sleeve 5, elasticity suction nozzle 6 and suction head 7, be equipped with volume display window 4 on the sleeve 5, be equipped with piston structure in the sleeve 5, piston structure is in under control button 1's the pushing down effect, the solution in the solution cavity is released in the downstream, piston structure's below is equipped with the spring and upwards resets in order to promote piston structure, volume adjust knob 2 is used for adjusting piston structure is at the ascending height of vertical side in order to adjust its a motion stroke, more one-step liquid output of adjusting.
The elastic suction nozzle 6 is assembled at the bottom of the sleeve 5 and communicated with the dissolving liquid cavity, the suction head 7 can be assembled at the bottom of the elastic suction nozzle 6 in a sealing mode and can be detached from the elastic suction nozzle 6 under the action of the suction head detaching button 3, a connecting rod is fixed at the bottom of the suction head detaching button 3, the end of the connecting rod extends out of the bottom of the elastic suction nozzle 6, and when the suction head detaching button 3 is pressed down, the connecting rod pushes the suction head 7 to detach the suction head 7.
Furthermore, a volume adjusting block is arranged in the sleeve 5, the volume adjusting knob 2 drives the volume adjusting block to rotate, a plurality of grooves which are located at different heights are formed in the volume adjusting block, and protrusions which can be inserted into the grooves in a matched mode are arranged on the piston structure.
Various pipette guns known in the art, such as the quick pipette disclosed in CN201086016Y, may also be used.
2.3
The quantitative pipetting device of example 2.1 can also adopt the following simplified structure:
the quantitative pipetting device comprises an outer sleeve 8, a piston 9 positioned in the outer sleeve 8 and a push-off mechanism arranged outside the outer sleeve, wherein:
a suction nozzle structure 13 communicated with the outer sleeve 8 is fixed at the bottom of the outer sleeve, and a detachable suction head 16 is detachably connected at the bottom of the suction nozzle structure 13;
a pressing button 10 is fixed on the top of the piston 9, an upper limiting bulge 11 and a lower limiting bulge 12 are fixed on the inner wall of the outer sleeve 8, and a compression spring is arranged between the piston 9 and the lower limiting bulge 12;
the push-off mechanism comprises a push-off button 18 and a connecting rod structure 14 fixed at the bottom of the push-off button 18, the push-off button 18 is connected with the top of the outer sleeve in a sliding manner, and the bottom of the connecting rod structure 14 is in contact with the top of the detachable sucker 16.
When the dissolving liquid is sucked, the detachable suction head 16 is fixed at the bottom of the push-off button 18, the press button 10 is pressed, then the detachable suction head 16 is placed in a packaged product, a dose of the dissolving liquid in the packaged product enters the detachable suction head 16, then the press button 10 is pressed, the dissolving liquid in the detachable suction head 16 is ejected, the push-off button 18 is pressed, the detachable suction head 16 is abandoned, and a new clean detachable suction head 16 is installed for the next use.
2.4
The quantitative pipetting device used in example 1.1 was used, except that the solution chamber 15 was empty and not filled with the solution.
Example 3
3.1
The utility model provides a packing has mesophragma rifle head of solution and freeze-drying preparation, includes mesophragma rifle head, be equipped with on the mesophragma rifle head and supply the inserted inlet of pipette, be equipped with the sealing member on the inlet, wherein be equipped with flexible mesophragma 20 in the mesophragma rifle head, flexible mesophragma will the mesophragma rifle head is separated into two cavities 21, packs solution and freeze-drying preparation in two cavities respectively.
Preferably, the seal is a removable cap or a sealing cap 22 that is breakable and accessible by the dosing mechanism.
Preferably, the shape of the septal gun head can be a round tube shape, a prism shape, a conical shape, a cartoon shape or the like. The shape of the septal lance tip does not affect its use.
Preferably, the flexible barrier is a PVC film.
3.2
The utility model provides a freeze-drying preparation based on ration pipetting device, includes ration pipetting device and one or more embodiment 3.1 septum rifle head 19, be equipped with on the septum rifle head and supply the ration pipetting device to insert and form the inlet of block, freeze-drying preparation is packing freeze-dried powder or freeze-dried piece. The dissolving solution is purified water, cosmetic water or essence water.
Preferably, the sealing cover is an aluminum cover, and the aluminum cover comprises a rubber plug in sealing connection with the liquid inlet and an aluminum layer coated outside the rubber plug and the liquid inlet. During the use, utilize the rifle head of pipetting gun body to prick aluminium lamination and rubber buffer, the rifle head enters into the interior block that forms of mesophragma rifle head, realizes one-hand operation, presses the control button of pipetting gun body, inflates in the packing body, under the effect of atmospheric pressure, and flexible mesophragma breaks, dissolves liquid and freeze-drying preparation and mixes, treats that freeze-drying preparation dissolves the back completely, opens sealed lid, will dissolve after the solution after dissolving and scribble in facial use.
The sealing cover can also be a sealing aluminum cover and a plastic cover nested on the sealing aluminum cover, and the center of the plastic cover is provided with a hole. When the flexible middle partition is used, the gun head is aligned to the opening, the aluminum cover is punctured and enters the packaging body, and the flexible middle partition is broken through inflation.
3.3
The quantitative pipetting device in example 3.2 can be the quantitative pipetting device in example 1.1, example 2.2 or example 2.3, and when the structure of example 1.3 is used, the solution chamber 15 is not filled with the solution, or the quantitative pipetting device in example 3.2 can be a common syringe, and the flexible septum can be broken.
Example 4
In order to achieve individualized dispensing of lyophilized formulation doses or types.
The packaging device for packaging the freeze-dried preparation comprises a plurality of free plug-in units 25 and a hard sealing cover 26, wherein a vent valve 31 is arranged on the hard sealing cover;
be equipped with the packing cavity 27 of packing freeze-dried preparation in each free grafting unit, the packing cavity with form in the circulation mouth 28 at grafting unit both ends is linked together, all be equipped with flexible seal membrane on the circulation mouth, when two grafting units are pegged graft, two packing cavity seal butt joints, sealed lid is used for sealing the circulation mouth of bottommost grafting unit firmly.
When the quantitative liquid transferring device is used, the hard sealing cover is sealed on the bottom flow port of the bottommost inserting unit, the vent valve 31 is matched with the bottom flow port, then the inserting units which are packaged with different freeze-drying preparations are inserted together according to individual selection to form an inserting gun head, the quantitative liquid transferring device is used for pricking the sealing film of the topmost inserting unit, a dissolving liquid is injected into the inserting gun head, in the process of injecting the liquid, the flexible sealing film is broken under the action of pressure, the packaging cavities are communicated, and the freeze-drying powder in the packaging cavities is dissolved and used by the dissolving liquid. And the bottom is sealed by a hard sealing cover to prevent the flexible sealing film at the bottom from cracking.
Therefore, the packaging problem of blending unstable components, such as combination of VC and arbutin, VC and nicotinamide, VC and collagen, ferulic acid and peptide, ferulic acid and baicalin and the like, can be separately stored in different free plug-in units, and when in use, the free plug-in units are plugged together for blending. Or multiple doses can be realized to be used immediately after being prepared, so that the dose flexibility is realized. For example, for some fixed components, 1 part of the fixed components can be used for acting, and 3 parts of the fixed components can be used for acting, and the fixed components can be freely mixed according to requirements.
Preferably, the bottom of the free plugging unit is a convex plugging part, the top of the free plugging unit is a concave plugging part matched with the convex plugging part, the convex plugging part is provided with a positioning flange 29, and the concave plugging part is provided with a positioning groove 30 matched with the positioning flange. When two adjacent free grafting units are pegged graft, when the locating flange inserts in another positioning groove, the flexible seal membrane in bottom of the free grafting unit that is located the top hugs closely the flexible seal membrane in top of the free grafting unit that is located the below, and when two flexible seal membranes broke under the pressure effect, two packing cavities were linked together.
Example 5
A freeze-dried preparation based on a quantitative liquid-transfering device comprises a quantitative liquid-transfering device which can suck and eject a dissolving solution quantitatively, or a packaging device which is also packaged with the freeze-dried preparation;
the dissolving solution is packaged in the quantitative liquid-transfering device, or is packaged in a packaged product separately, or is packaged in the packaging device separately from the freeze-dried preparation.
The quantitative liquid-transfering device is a dropping bottle, a quantitative squeezing bottle, a pressing pump bottle or a liquid-transfering gun. The packaging device for packaging lyophilized preparation is spherical, annular, tubular, heart-shaped, star-shaped, prism-shaped, cone-shaped or cartoon-shaped with liquid inlet and air vent valve. As shown in FIG. 9, the quantitative liquid transfer device A is a push pump bottle, the packaging device is a sphere, the quantitative liquid transfer device B is a push pump bottle, the packaging device is a round tube, the quantitative liquid transfer device C is a quantitative squeeze bottle, and the packaging device is a star.
In addition, different forms of packaging devices can be matched and used in one set of products to package freeze-dried preparations with different functions for distinguishing, for example, the freeze-dried preparation with the water replenishing function is packaged in a spherical packaging device, and the freeze-dried preparation with the whitening function is packaged in a star-shaped packaging device. The user takes according to the demand, is convenient for discern.
Spatially relative terms, such as "upper," "lower," "left," "right," and the like, may be used in the embodiments for ease of description to describe one element or feature's relationship to another element or feature as illustrated in the figures. It will be understood that the spatial terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "lower" can encompass both an upper and a lower orientation. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
Moreover, relational terms such as "first" and "second," and the like, may be used solely to distinguish one element from another element having the same name, without necessarily requiring or implying any actual such relationship or order between such elements.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (24)
1. A freeze-dried preparation based on a quantitative liquid transfer device is characterized by comprising the quantitative liquid transfer device which can suck and pump out a dissolving solution quantitatively or a packaging device which is also packaged with the freeze-dried preparation;
the dissolving solution is packaged in the quantitative liquid-transfering device, or is packaged in a packaged product separately, or is packaged in the packaging device separately from the freeze-dried preparation.
2. A lyophilized formulation based on a quantitative pipetting device according to claim 1 wherein the quantitative pipetting device is a dropper bottle, a quantitative squeeze bottle, a push pump bottle or a pipette gun.
3. The freeze-dried preparation based on a quantitative pipetting device according to claim 1 wherein the packaging device in which the freeze-dried preparation is packaged is in the shape of a sphere, a ring, a tube, an loving heart, a star, a prism, a cone or a cartoon with a liquid inlet and a gas vent valve.
4. The lyophilized formulation based on a quantitative pipetting device as recited in claim 1 wherein the outlet of the quantitative pipetting device is snap-connectable to the inlet of the package or packaging device.
5. The freeze-dried preparation based on a quantitative pipetting device as recited in claim 1 wherein the quantitative pipetting device is a quantitative pipetting gun, a solution storage chamber for packaging solution and a quantitative mechanism for controlling the pipetting are arranged in the quantitative pipetting gun, a solution outlet communicated with the solution storage chamber is arranged at the bottom of the quantitative pipetting gun, and a detachable sealing end cap is arranged on the solution outlet;
the packaging device packaged with the freeze-drying preparation is a gun head, a ventilation valve is arranged on the gun head, the dissolved liquid outlet is matched and clamped with a liquid inlet of the gun head, and a sealing piece is arranged on the liquid inlet.
6. The quantitative pipette device based lyophilized formulation of claim 5, wherein the quantitative pipette gun comprises an outer sleeve and the dosing mechanism, wherein:
the bottom of the outer sleeve is provided with the solution outlet;
the quantifying mechanism comprises a piston positioned in the outer sleeve and an upper limiting bulge and a lower limiting bulge which are fixed on the inner wall of the outer sleeve, the top of the piston is fixed with a pressing button, a compression spring is arranged between the piston and the lower limiting bulge, and the space at the bottom of the piston is a solution cavity.
7. A lyophilized formulation based on a quantitative pipetting device according to claim 6 wherein the outer sleeve has a configuration of a thick top and thin bottom, or a cylindrical configuration, or a configuration with a bulge formed in the middle.
8. A lyophilized formulation based on a quantitative pipetting device according to claim 5 wherein the sealing member is a sealing cap or a breakable sealing membrane.
9. The quantitative pipetting device-based lyophilized formulation according to claim 5 wherein a plurality of tips are packaged in a single package, and the quantitative pipetting gun is packaged in addition to or in common with a plurality of tips;
or the quantitative pipette is clamped and packaged with one gun head, and the other gun heads are independently packaged.
10. The lyophilized formulation based on a quantitative pipetting device according to claim 5, wherein the tip is in the shape of a sphere, a ring, a tube, an loving heart, a star, a prism, a cone or a cartoon character.
11. A lyophilized formulation based on a quantitative pipetting device according to claim 1 wherein the quantitative pipetting device is not packaged with a solution, the solution is packaged separately in a package, the package is provided with an opening for the quantitative pipetting device to enter for pipetting, and the opening is provided with a detachable sealing cover.
12. A freeze-dried formulation based on a quantitative pipetting device according to claim 11 wherein the package is a packaging bottle, a packaging can or a packaging bag.
13. A lyophilized formulation based on a dosing pipetting device as recited in claim 11 wherein the dosing pipetting device comprises an outer sleeve, a piston within the outer sleeve, and a push-off mechanism disposed outside the outer sleeve, wherein:
a suction nozzle structure communicated with the outer sleeve is fixed at the bottom of the outer sleeve, and a detachable suction head is detachably connected to the bottom of the suction nozzle structure;
a pressing button is fixed on the top of the piston, an upper limiting bulge and a lower limiting bulge are fixed on the inner wall of the outer sleeve, and a compression spring is arranged between the piston and the lower limiting bulge;
the push-off mechanism comprises a push-off button and a connecting rod structure fixed at the bottom of the push-off button, the push-off button is connected with the top of the outer sleeve in a sliding manner, and the bottom of the connecting rod structure is in contact with the top of the detachable suction head.
14. The quantitative pipette device based lyophilized formulation of claim 11, wherein the quantitative pipette gun comprises an outer sleeve and a dosing mechanism, wherein:
the bottom of the outer sleeve is provided with a solution outlet, and the solution outlet is provided with a detachable sealing end cover;
the quantitative mechanism comprises a piston positioned in the outer sleeve, and an upper limiting bulge and a lower limiting bulge which are fixed on the inner wall of the outer sleeve, wherein the top of the piston is fixed with a pressing button, and a compression spring is arranged between the piston and the lower limiting bulge.
15. The quantitative pipetting device-based lyophilized preparation according to claim 1, wherein the quantitative pipetting device is not packaged with a solution separately packaged in the packaging device, the packaging device is a septum tip, a liquid inlet for the quantitative pipetting device to insert and form a clamping is formed in the septum tip, a sealing member is arranged on the liquid inlet, a flexible septum is arranged in the tip, the flexible septum separates the packaging body into two chambers, and the two chambers are respectively packaged with the solution and the lyophilized preparation.
16. A lyophilized formulation based on a quantitative pipetting device as recited in claim 15 wherein the seal is a removable cap or a sealed cap that is breakable and accessible by the quantitative pipetting device.
17. The quantitative pipette device-based lyophilized formulation according to claim 15, wherein the sealing cap is an aluminum plastic film;
or the sealing cover is an aluminum cover, and the aluminum cover comprises a rubber plug which is hermetically connected with the liquid inlet and an aluminum layer which is coated outside the rubber plug and the liquid inlet;
or the sealing cover is a sealing aluminum cover and a plastic cover nested on the sealing aluminum cover, and the center of the plastic cover is provided with a hole.
18. The lyophilized formulation based on a quantitative pipetting device according to claim 15 wherein the shape of the septal tip is spherical, annular, tubular, heart-shaped, star-shaped, prismatic, conical, or cartoon-shaped, or the like.
19. The lyophilized preparation based on a quantitative pipetting device according to claim 1, which comprises only a quantitative pipetting device capable of sucking and discharging a solution quantitatively, wherein the quantitative pipetting device is a quantitative pipetting gun, a solution storage chamber for packaging the solution and a quantitative mechanism for controlling the liquid discharge are arranged in the quantitative pipetting gun, a solution outlet communicated with the solution storage chamber is arranged at the bottom of the quantitative pipetting gun, and a detachable sealing end cap is arranged on the solution outlet.
20. The freeze-dried preparation based on a quantitative pipetting device as recited in claim 1 wherein the packaging means in which the freeze-dried preparation is packaged comprises a plurality of free-access units and a hard sealing cap provided with a vent valve;
the automatic packaging device is characterized in that a packaging cavity for packaging a freeze-dried preparation is arranged in each free inserting unit, the free inserting unit is provided with the packaging cavity communicated with circulation ports formed at two ends of the inserting unit, flexible sealing films are arranged on the circulation ports, when the two inserting units are inserted, the two packaging cavities are in sealed butt joint, and the hard sealing covers can be inserted into the inserting units at the bottommost part to seal the circulation ports hard.
21. The lyophilized formulation for a metered dose pipetting device according to claim 20, wherein the free plug unit has a male plug portion at the bottom and a female plug portion at the top, the female plug portion being adapted to the male plug portion, the male plug portion having a positioning flange thereon and the female plug portion having a positioning groove adapted to the positioning flange thereon.
22. The freeze-dried preparation based on quantitative pipetting device as recited in claim 1, wherein the quantitative pipetting device is a packaging bottle and a dropper detachably assembled on the packaging bottle, and the port of the dropper can be matched with the liquid inlet of the packaging device to realize the clamping by butt joint.
23. The freeze-dried preparation based on a quantitative pipetting device as recited in claim 1 wherein the quantitative pipetting device is a squeeze bottle, the end of the squeeze bottle is provided with a squeeze outlet, the squeeze outlet is provided with a detachable sealing cover, the squeeze bottle is a rigid packaging bottle, the bottle body is provided with a flexible pressing part, and the squeeze outlet can be matched with the liquid inlet of the packaging device to realize butt joint and clamping.
24. The lyophilized formulation based on a quantitative pipetting device according to claim 1, wherein the quantitative pipetting device is a push bottle comprising a push bottle body and a push pump, the push pump outlet being mateable with the liquid inlet of the packaging device for docking and snap-fitting.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020111117476 | 2020-10-16 | ||
| CN202011111747 | 2020-10-16 |
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| CN114367322A true CN114367322A (en) | 2022-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110104382.2A Pending CN114367322A (en) | 2020-10-16 | 2021-01-26 | Freeze-drying preparation based on quantitative liquid transfer device |
| CN202120215861.7U Active CN216799875U (en) | 2020-10-16 | 2021-01-26 | Freeze-dried preparation package based on quantitative liquid transfer device |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202120215861.7U Active CN216799875U (en) | 2020-10-16 | 2021-01-26 | Freeze-dried preparation package based on quantitative liquid transfer device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114752658A (en) * | 2022-06-15 | 2022-07-15 | 上海邦先医疗科技有限公司 | Nucleic acid detection method and system based on micro-fluidic chip |
-
2021
- 2021-01-26 CN CN202110104382.2A patent/CN114367322A/en active Pending
- 2021-01-26 CN CN202120215861.7U patent/CN216799875U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114752658A (en) * | 2022-06-15 | 2022-07-15 | 上海邦先医疗科技有限公司 | Nucleic acid detection method and system based on micro-fluidic chip |
| CN114752658B (en) * | 2022-06-15 | 2022-10-14 | 江苏汇先医药技术有限公司 | Nucleic acid detection method and system based on micro-fluidic chip |
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| CN216799875U (en) | 2022-06-24 |
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