CN1143464A - Calcium L-threonate for food additives and preparing process and use thereof - Google Patents
Calcium L-threonate for food additives and preparing process and use thereof Download PDFInfo
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- CN1143464A CN1143464A CN96106507A CN96106507A CN1143464A CN 1143464 A CN1143464 A CN 1143464A CN 96106507 A CN96106507 A CN 96106507A CN 96106507 A CN96106507 A CN 96106507A CN 1143464 A CN1143464 A CN 1143464A
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- threonic acid
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Abstract
A food additive, L-calcium threonate, for beverage, solid food, or flavourings serves to improve the eating enjoyment of food and supplement calcium for human body. Its preparation method is rational, simple and easy.
Description
The present invention relates to food additives, particularly relate to a kind of preparation method and its usage of l threonic acid food additives.
Quickening along with development and national economy and people's lives rhythm, the drink that makes things convenient for miscellaneous emerges in an endless stream, do not considering whether these drinks meet under the prerequisite of sanitary standard, it is found that, various fruit-flavored beverages, composite beverage and the carbonic acid vapour beverage etc. of market sale now, ubiquity mouthfeel and is sent out puckery, compares problems such as sweet taste is impure with new fruit drink.On the other hand, people know, calcium is one of most important element in the human body, it participates in all vital movement processes, especially the ionized calcium in the blood plasma is being brought into play prior physiological action, it is necessary to the function of keeping neuromuscular, skeletal system and the permeability of cell membrane and capillary, and the condensing of the activation of many enzymes, blood, renal function and keeping of respiratory function all be unable to do without it, and it is also in the release of neurotransmitter and hormone, amino acid whose picked-up with in conjunction with, B simultaneously
12Physiology courses such as absorption in also bringing into play important effect.But, according to investigation in recent years, the actual intake of China resident calcium is well below normal person's calcium demand: national average calcium intake only is that 500mg/ is about day, and normal person's calcium demand should be 800～1200mg/ day, both differ very big, so chronically, seriously calcium deficiency will inevitably cause multiple diseases such as osteoporosis.And at present, China still do not have a kind ofly to make absorption of human body and conversion ratio height, enteron aisle is not had the food additives with calcium supplementing effect of shortcoming such as stimulation.
The purpose of this invention is to provide a kind of absorption conversion ratio that both can significantly improve the human calcium, can improve the food additives of food mouthfeel, elimination beverage astringent taste again.
Another object of the present invention provides a kind of preparation method of above-mentioned food additives.
A further object of the invention provides a kind of purposes of above-mentioned food additives.
L threonic acid as food additives of the present invention is white particle, and is almost tasteless, can be water-soluble, be insoluble to alcohol, and ether and chloroform, its molecular formula is C
8H
14O
10Ca, chemical structural formula is:
Its preparation method is: add a certain amount of L-ascorbic acid (V in water
c), after the L-ascorbic acid is dissolved fully, slowly add calcium carbonate under stirring, under 10～60 ℃, in above-mentioned system, slowly drip hydrogen peroxide, after in 40～80 ℃, being incubated 1～4 hour, add activated carbon again, filter, filtrate concentrates down at 30～90 ℃, crystallization at room temperature, dry down at 50～100 ℃.
In the preparation method of described l threonic acid, the adding of calcium carbonate is wanted slowly, in order to avoid produce a large amount of carbon dioxides suddenly, is being with in the system liquid to go out outside the container.
Can also comprise the filter cake that filters behind the activated carbon adding among the preparation method of l threonic acid of the present invention, with 80 ℃ of hot water wash twice, the merging of washing lotion and filtrate concentrate.
Preparation method's technology of l threonic acid of the present invention is reasonable, simple, and productive rate reaches as high as 90%, and the purity height, is that collection is replenished the calcium and seasoning is the food additives of one.
Food additives l threonic acid of the present invention is the metabolite of L-ascorbic acid in human body, has participated in a lot of physiology courses, and is nontoxic, has no side effect, and helps human body to ascorbic absorption, and can replenish human calcium's content rapidly.
Be to utilize of the experiment of SD rat below to the situation that absorbs and the serum calcium situation of change of l threonic acid.
The SD male rat is used in experiment, conforms after buying and observes 3, is divided into three groups then at random, two experimental group (branch high and low dose), a blank group.The weight of animals 203.75 ± 8.76 grams.
Grouping back animal monoculture was at first fed the artificial calcic feed of preparing 3 days in metabolic cage, make it adapt to feed and change.Begin then to change and feed the calcium deficiency feed, to the 4th day on the calcium deficiency feed basis of continuing to feed, press high dose 80mgCa
2+/ 1 day and low dosage 40mgCa
2+/ only 1 day, irritate for respectively two experimental group animals to be fed with 3% starch solution of l threonic acid, once a day, the blank group is irritated the starch suspension of stomach 3%.Each treated animal is freely drunk deionized water.
The Nutrition and Metabolism cage can be urinated mouse, excrement separates fully, and regularly collect whole urine, excrement, numbering every day, is used for quantitative assay.
Animal feeding environment: 20 ℃ ± 1 ℃ of room temperature, humidity 55%, Artificial Control light application time 12hr/ days.
The calcium deficiency feed formula is as follows:
％
Egg albumen powder 24
Starch 40
Sucrose 23
Soybean oil 5
Cellulose 4
Mixed inorganic 3
Mixed vitamin 1
During detection, each animal blood, urine, excrement and feed before and after the experiment are carried out calcium content measure.Blood, urine are directly measured, and the ashing after drying of excrement, feed is measured then.All adopt useful titration and measure, each sample is made three parallel samples, gets average, and the result is as follows:
Table 1 SD rat absorbs situation (%) to l threonic acid
| Dosage | The SD number of rats | Absorptivity | Utilization rate | Net utilization |
| 626mg/ day | ????10 | ?95.30 | ?76.83 | ?73.22 |
| 313mg/ day | ????10 | ?89.33 | ?89.13 | ?79.62 |
Table 2 is compared blood calcium situation of change mg/dl with the blank group
| Dosage | The SD number of rats | The blood calcium value added |
| 626mg/ day | ????2.685 | |
| 313mg/ day | ????1.480 |
More than two groups of tests, animal calcium net utilization all reaches more than 70%, illustrates that l threonic acid is a kind of goods of replenishing the calcium with high-absorbility, high usage.
Be the experimental result behind the edible l threonic acid of human body below.
Select 10 of young man volunteers, 22 years old mean age, do not have the absorption of other calcium preparation and high calcium food during being tried.The oral for each person every day l threonic acid of experimenter 1 time, each 1.72 grams, calcic 220mg took 7 days continuously, respectively at before the experiment and after the experiment, left and took 4 hours urine on an empty stomach early morning, urinated calcium and measured.Under the similarity condition, the oral of calcium citrate, calcium gluconae and calcium carbonate and detection have been carried out.The mensuration of urine calcium is used the EDTA titration, and the mensuration of UCr is used the picric acid colorimetric method.
Three index determining results in experiment front and back such as table 3.
Table 3
| 4 hours urine calcium total amounts (mg) | Ca mg/100ml urine | Ca mg/g creatinine | ||||
| Before the experiment | After the experiment | Before the experiment | After the experiment | Before the experiment | Experiment | |
| Mean value standard deviation number confidence factor probability | ?27.09??????73.03 ?10.81??????22.72 ?10?????????10 ?????5.7739 ?????＜0.01 | ?20.64???????36.41 ?4.20????????6.68 ?10??????????10 ?????6.3200 ?????＜0.01 | ?144.15???266.62 ?53.67????109.05 ?10???????10 ?????3.1864 ?????＜0.01 | |||
Above experimental result credit is by statistics analysed processing, and difference all has highly significant between three each data of index experiment front and back, and the P value illustrates that all less than 0.01 l threonic acid can make human calcium's accretion of stock rapidly, reaches the purpose of replenishing human calcium's content rapidly.
Before and after the experiment, several calcium preparations are taken urine calcium amount after 0～4 hour to such as table 2.
Table 4
| The L-threonic acid calcium | Calcium citrate | Calcium gluconae | Calcium carbonate | |
| 0-4 hour urine calcium amount (mg/dl urine) after taking medicine | 36.41 | ?19 | ?14 | |
| 0-4 hour urine calcium increment (mg/dl urine) after taking medicine | 15.8 | ?9.8 | ?6.9 | |
| 0-4 hour urine calcium amount (mg/mg creatinine) after taking medicine | 0.27 | ?0.15 | ?0.13 | |
| 0-4 hour urine calcium increment (mg/mg creatinine) after taking medicine | 0.123 | ?0.081 | ?0.045 |
Above experimental result explanation, every result of l threonic acid all is better than calcium citrate, calcium gluconae, calcium carbonate, is more suitable for absorption by human body.
Because the optical activity of the l threonic acid as food additives of the present invention causes its biologically active, it is absorbed in vivo easily, can when replenishing the calcium, play the effect that improves food taste.Be that l threonic acid can under the prerequisite of the mouthfeel of improving food, not only increase the nutrition of food as additive of flavourings such as solid food additive, monosodium glutamate such as beverage additive, bread or biscuits, also can play the effect of replenishing the calcium rapidly.
L threonic acid can improve the mouthfeel of all kinds of fruit drinks, composite beverage and carbonic acid vapour beverage as beverage additive, remove astringent taste, promote the fragrant and sweet smell of beverage, its main cause is that l threonic acid has the composition (as pigment, tannic acid etc.) of astringent taste to combine with these to have formed tasteless complex compound.Addition is preferably 0.0.1～1%.
Product below by 10 volunteers that participate in this experiment are repaid contrast.The characteristic of improving beverage mouthfeel that this beverage additive has is described.
Choose the 125ml almond bevertage, to wherein adding the 50mgL-threonic acid calcium, after 5 minutes, repay with the almond bevertage contrast product that do not add l threonic acid, 10 volunteers think that all mouthfeel obviously improves, and do not have puckery nonirritant, pure fragrant and sweet flavor increase.
Other gets 125ml orange granule juice beverage, to wherein adding the 50mgL-threonic acid calcium, makes the contrast product with blank after 5 minutes and repays, and 10 volunteers think that all mouthfeel obviously improves, and do not have puckery nonirritant, and are pure fragrant and sweet good to eat, approach the pure juice taste.
Get the Shanhai Pass Orange soda (carbonic acid vapour type) of 125ml again, to wherein adding the 50mgL-threonic acid calcium, make the contrast product with blank after 5 minutes and repay, 10 volunteers think that all mouthfeel obviously improves, and are no puckery, pure fragrant and sweet good to eat, near the pure juice mouthfeel.
Choose Sprite, Finda each 200mL of carbonic acid vapour beverage of being produced by Coca-Cola again, to wherein adding the 50mgL-threonic acid calcium, make contrast product with blank after 5 minutes and repay, 10 volunteers think that all mouthfeel obviously improves no puckery and sweet taste increase.
L threonic acid can increase the sweet taste of food as solid food additives such as bread, biscuits, increases the nutrition of food, more importantly is to reach the purpose of replenishing the calcium, and addition is preferably 1～5%.
The present invention is described further below in conjunction with embodiment.
Embodiment
In the reactor that agitator and cooling water sandwich are installed.The L-ascorbic acid that adds 25Kg water and 17.6Kg, after the L-ascorbic acid is fully dissolved, stir and slowly add 20Kg calcium carbonate down, remain at system temperature under 30～40 ℃ the situation, slowly drip the 40Kg hydrogen peroxide, and keep 30～40 ℃ of constant temperature, add activated carbon then, be warmed up to and be concentrated to 1/3 of original volume under 60 ℃, cooling, crystallization, the dry finished product l threonic acid that gets.
The l threonic acid that makes as beverage additive, is added in the orange juice (every bottle contains l threonic acid 1.6g).Children's (7 years old age) by 10 serious calcium deficiency drink three bottles every day, drink continuously 15 days, and 10 children declare with one accord, the orange juice that has added additive is drunk than getting well of not adding, and does not have astringent taste, and mouthfeel is fragrant and sweet, and 10 children's calcium deficiency phenomenon is clearly better, and cure rate reaches 90%, and concrete testing result is as follows:
The responder is 4 efficient 40% in 3 days
The responder is 7 efficient 70% in 4 days
The responder is 10 efficient 100% in 10 days
8 cure rates 80% of healing person in 10 days
9 cure rates 90% of healing person in 15 days
With the l threonic acid that makes additive as bread, select children's (8 years old age) of 10 serious calcium deficiency, eat two gems (including l threonic acid 4g) every day, eat 10 days continuously after, testing result is as follows:
Responder 7 people efficient 70% in 5 days
Responder 10 people efficient 100% in 10 days
Healing person's 8 people's cure rates 80% in 10 days
Above presentation of results, employing l threonic acid of the present invention can improve the mouthfeel and the grade of food significantly as the additive of varieties of food items, more adapt to absorption by human body, particularly after having eaten the food that contains l threonic acid, can increase the calcium reserves of human body promptly, significantly, reach the purpose of replenishing human calcium's content rapidly.
Claims (10)
1. food additives is characterized in that containing l threonic acid.
2. the preparation method of food additives as claimed in claim 1 is characterized in that adding a certain amount of L-ascorbic acid (V in water
c), after the L-ascorbic acid is dissolved fully, slowly add calcium carbonate under stirring, under 10～60 ℃, in above-mentioned system, slowly drip hydrogen peroxide, after in 40～80 ℃, being incubated 1～4 hour, add activated carbon again, filter, filtrate concentrates down at 30～90 ℃, crystallization at room temperature, dry down at 50～100 ℃.
In the preparation method of described l threonic acid, the adding of calcium carbonate is wanted slowly, in order to avoid produce a large amount of carbon dioxides suddenly, is being with in the system liquid to go out outside the container.
3. preparation method as claimed in claim 2 is characterized in that the filter cake that filters behind the activated carbon adding, and with 80 ℃ of hot water wash twice, washing lotion is concentrated with the filtrate merging.
4. the purposes of a l threonic acid is characterized in that being used for beverage additive.
5. purposes as claimed in claim 4, the addition that it is characterized in that additive is 0.01～0.1%.
6. the purposes of a l threonic acid is characterized in that being used for the solid food additive.
7. purposes as claimed in claim 6, the addition that it is characterized in that additive is 1～5%.
8. purposes as claimed in claim 5 is characterized in that solid food is bread, biscuit, and dilated food.
9. the purposes of a l threonic acid is characterized in that being used for additive of flavourings.
10. purposes as claimed in claim 7 is characterized in that flavouring is monosodium glutamate, cooking wine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106507A CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106507A CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1143464A true CN1143464A (en) | 1997-02-26 |
| CN1039571C CN1039571C (en) | 1998-08-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96106507A Expired - Fee Related CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
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| Country | Link |
|---|---|
| CN (1) | CN1039571C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000010962A1 (en) * | 1998-08-18 | 2000-03-02 | Beijing Juneng Asia Pacific Life Scientific Research Center | Chromium l-threonate, process for preparation of the same and their use |
| US6713513B2 (en) * | 2001-07-03 | 2004-03-30 | Juneng Industry Co., Ltd. | Method for treating cartilage related diseases |
| US6727288B2 (en) * | 2001-03-07 | 2004-04-27 | Juneng Industry Co., Ltd. | Method for treating bone fracture |
| US8142803B2 (en) | 2007-03-22 | 2012-03-27 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US8377473B2 (en) | 2009-07-01 | 2013-02-19 | Magceutics, Inc. | Slow release magnesium composition and uses thereof |
| CN112047836A (en) * | 2020-09-16 | 2020-12-08 | 浙江天瑞化学有限公司 | Preparation method and equipment of calcium L-threonate |
| CN112724032A (en) * | 2020-12-28 | 2021-04-30 | 宁波盈前科技有限公司 | Threonine calcium product and production method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
| WO1990012571A1 (en) * | 1989-04-07 | 1990-11-01 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin c |
-
1996
- 1996-06-13 CN CN96106507A patent/CN1039571C/en not_active Expired - Fee Related
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000010962A1 (en) * | 1998-08-18 | 2000-03-02 | Beijing Juneng Asia Pacific Life Scientific Research Center | Chromium l-threonate, process for preparation of the same and their use |
| CN1074762C (en) * | 1998-08-18 | 2001-11-14 | 北京巨能亚太生命科学研究中心 | Process for preparing chromium L-threonate, its preparing process and application |
| US6548687B1 (en) | 1998-08-18 | 2003-04-15 | Kai Yu | Chromium L-threonate, process for preparation of the same and their use |
| US6727288B2 (en) * | 2001-03-07 | 2004-04-27 | Juneng Industry Co., Ltd. | Method for treating bone fracture |
| US6713513B2 (en) * | 2001-07-03 | 2004-03-30 | Juneng Industry Co., Ltd. | Method for treating cartilage related diseases |
| EP1443918A4 (en) * | 2001-07-03 | 2004-11-24 | Juneng Industry Co Ltd | Calcium l-threonate for preventing or treating bone facture |
| US8178133B2 (en) | 2007-03-22 | 2012-05-15 | Magceutics, Inc. | Magnesium compositions and uses thereof |
| US9737563B2 (en) | 2007-03-22 | 2017-08-22 | Neurocentria, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US8178132B2 (en) | 2007-03-22 | 2012-05-15 | Magceutics, Inc. | Magnesium-containing food compositions |
| US8178118B2 (en) | 2007-03-22 | 2012-05-15 | Magceutics, Inc. | Magnesium compositions and uses thereof for cognitive function |
| US8142803B2 (en) | 2007-03-22 | 2012-03-27 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US9757414B2 (en) | 2007-03-22 | 2017-09-12 | Neurocentria, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US8637061B2 (en) | 2007-03-22 | 2014-01-28 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US8163301B2 (en) | 2007-03-22 | 2012-04-24 | Magceutics, Inc. | Magnesium compositions and uses thereof for metabolic disorders |
| US9125878B2 (en) | 2007-03-22 | 2015-09-08 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US9616038B2 (en) | 2007-03-22 | 2017-04-11 | Neurocentria, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| US8734855B2 (en) | 2009-07-01 | 2014-05-27 | Magceutics, Inc. | Slow release magnesium composition and uses thereof |
| US8377473B2 (en) | 2009-07-01 | 2013-02-19 | Magceutics, Inc. | Slow release magnesium composition and uses thereof |
| CN112047836A (en) * | 2020-09-16 | 2020-12-08 | 浙江天瑞化学有限公司 | Preparation method and equipment of calcium L-threonate |
| CN112724032A (en) * | 2020-12-28 | 2021-04-30 | 宁波盈前科技有限公司 | Threonine calcium product and production method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1039571C (en) | 1998-08-26 |
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