CN114343583A

CN114343583A - 3D fluorescence tomography animal molecule image scanning equipment

Info

Publication number: CN114343583A
Application number: CN202210023505.4A
Authority: CN
Inventors: 窦少彬
Original assignee: Suzhou Alte Computing Technology Co ltd
Current assignee: Suzhou Alte Computing Technology Co ltd
Priority date: 2022-01-10
Filing date: 2022-01-10
Publication date: 2022-04-15

Abstract

The invention provides a 3D fluorescence tomography animal molecular image scanning device, which comprises a shell, a transparent placing mechanism arranged in the shell and provided with a scanning cavity, and a scanning mechanism arranged in the scanning cavity and sleeved above the placing mechanism, wherein the scanning mechanism comprises a lifting component arranged on the bottom wall of the scanning cavity, an adjusting component arranged on the lifting component, and a scanning piece arranged on the adjusting component; the adjusting assembly comprises a lifting seat and a moving piece, wherein one end of the lifting seat is arranged on the lifting assembly through a rotating piece, the end face of the lifting seat is provided with a scanning port, the moving piece is arranged on the wall of the scanning port and moves on the wall of the port, and the moving piece is connected with the scanning piece; the opening of the scanning port is circular; the invention can conveniently and comprehensively scan the small living animal, improves the imaging details of the small living animal and ensures the accuracy of the imaging details.

Description

3D fluorescence tomography animal molecule image scanning equipment

Technical Field

The invention relates to the technical field of optical molecular imaging, in particular to a 3D fluorescence tomography animal molecular image scanning device.

Background

In vivo bioluminescence imaging (in vivo bioluminescence imaging) is a molecular and gene expression analysis and detection system developed in recent years. It consists of a sensitive CCD and its analysis software and luciferase (luciferase) and luciferin (luciferin) as reporters. By utilizing a sensitive detection method, researchers can directly monitor biological processes such as growth and metastasis of tumors in living organisms, infectious disease development processes, expression of specific genes and the like, the small animal living body fluorescence imaging technology is increasingly popularized and applied at home and abroad, more and more researchers hope to track and observe the growth of tumor cells in the living organisms and the reaction of drug treatment for a long time through the technology, hope to observe the distribution and metabolism condition of fluorescence-labeled polypeptides, antibodies and small molecular drugs in the bodies, compared with the traditional technology, the living body fluorescence imaging technology does not need to kill animals, can repeatedly track and image the same animal for a long time, can improve the comparability of data, and avoids the influence of individual difference on test results; the distribution and metabolic condition of the marker in the animal body can be known, and the defects of the traditional in vitro experiment method are avoided; in particular, the problem can be researched by a primitive method, namely, the research object does not need to be marked in advance, and then the behavior of the research object is researched by using a fluorescent marker, so that the observation result is real and reliable.

When present traditional toy live body fluorescence imaging equipment scans the toy, earlier carry out fluorescence labeling to the live body toy, scan the toy again, but current scanning device is not convenient for carry out the accurate scanning to each position of toy when scanning the toy, leads to the details of the formation of image of live body toy accurate inadequately.

Disclosure of Invention

Aiming at the technical problems, the invention provides a 3D fluorescence tomography animal molecular image scanning device which can conveniently and comprehensively scan living small animals, improve the imaging details of the living small animals and ensure the accuracy of the imaging details.

In order to achieve the purpose, the invention provides the following technical scheme: A3D fluorescence tomography animal molecule image scanning device comprises a shell, a transparent placing mechanism arranged in the shell and provided with a scanning cavity, and a scanning mechanism arranged in the scanning cavity and sleeved above the placing mechanism, wherein the scanning mechanism comprises a lifting assembly arranged on the bottom wall of the scanning cavity, an adjusting assembly arranged on the lifting assembly, and a scanning piece arranged on the adjusting assembly;

the adjusting assembly comprises a lifting seat and a moving piece, one end of the lifting seat is arranged on the lifting assembly through a rotating piece, the end face of the lifting seat is provided with a scanning port, the moving piece is arranged on the wall of the scanning port and moves on the wall of the port, and the moving piece is connected with the scanning piece; the opening of the scanning port is circular.

Preferably, a connecting port and a heat dissipation port are formed in the side surface of the shell, and a lifting plate movably connected is arranged in the connecting port; the opening of the heat dissipation port is provided with a heat dissipation plate, and the heat dissipation plate is provided with a plurality of heat dissipation holes; and a filter screen is arranged on the heat dissipation holes.

Preferably, the transparent placing mechanism comprises a rotary table arranged on the bottom wall of the scanning cavity, a height-adjusting piece arranged on the rotary table, and a placing block arranged on the height-adjusting piece, wherein a placing groove is formed in the upper end face of the placing block, and the placing block is made of transparent materials.

Preferably, the height adjusting piece comprises a telescopic arm, a telescopic screw and a telescopic rod, wherein the bottom end of the telescopic arm is arranged on the turntable, the top end face of the telescopic arm is provided with a telescopic groove, the bottom end of the telescopic arm penetrates through the telescopic groove, the telescopic rod is arranged in the telescopic groove, the top end of the telescopic rod penetrates through the telescopic groove, the telescopic rod is connected with the placing block and sleeved on the telescopic screw, the telescopic rod is in threaded connection with the telescopic screw, the side face of the telescopic rod is provided with a limiting block, and the limiting block is arranged in a limiting groove formed in the inner wall of the telescopic groove along the vertical direction; the telescopic rod is made of transparent materials.

Preferably, the lifting assembly comprises two lifting screws vertically arranged on the bottom wall of the scanning cavity and two lifting blocks respectively sleeved on the lifting screws and in threaded connection with the lifting screws, and the lifting blocks are connected with the side face of the lifting seat through the rotating member.

Preferably, the rotating part comprises two rotating rods, one end of each rotating rod is arranged on the side face of the lifting seat, the other end of each rotating rod is connected with the lifting block, the rotating gear is sleeved on one of the rotating rods, the adjusting motor is arranged on the lifting block, the output end of the adjusting motor is connected with the adjusting gear, and the adjusting gear is meshed with the rotating gear.

Preferably, the lifting seat is sleeved on the placing block through a scanning port, and an annular driving groove is formed in the wall of the scanning port; the moving piece comprises a fixed rack and a driving block which are arranged on the bottom wall of the driving groove, and a driving gear which is arranged on the driving block and meshed with the fixed rack, and the driving gear is driven by a motor; the driving block is connected with the scanning piece.

Preferably, a moving groove is formed in the side face of the driving block, and a moving block connected with the driving block is arranged in the moving groove.

The invention has the beneficial effects that: through directly placing the live body toy on transparent placing mechanism, rethread scanning mechanism is convenient for carry out comprehensive scanning to the toy, realizes carrying out comprehensive scanning to the live body toy, has improved the detail that forms images to the toy to the accuracy of formation of image detail has been guaranteed, and only can realize through scanning device mechanism that convenient to use is to the comprehensive scanning of toy.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention without limiting the invention in which:

fig. 1 is a schematic diagram of a simple structure of a 3D fluorescence tomography molecular imaging scanning apparatus according to the present invention.

Fig. 2 is a schematic diagram of an internal structure of a 3D fluorescence tomography molecular imaging scanning apparatus according to the present invention.

Fig. 3 is a schematic structural diagram of the transparent placing mechanism and the scanning mechanism of the invention.

Fig. 4 is a schematic structural view of the lifting base of the present invention.

FIG. 5 is a schematic diagram of a moving element according to the present invention.

Fig. 6 is a schematic structural view of the transparent placement mechanism of the present invention.

Fig. 7 is an enlarged schematic view of the structure at the position a of the present invention.

In the figure: 1. a housing; 2. a connecting port; 3. a lifting plate; 4. a heat dissipation plate; 5. a scanning chamber; 6. a lifting screw; 7. a lifting block; 8. a lifting seat; 9. a scanning member; 10. adjusting the motor; 11. an adjusting gear; 12. a rotating gear; 13. a height adjusting piece; 14. placing the blocks; 15. a placement groove; 16. a scanning port; 17. a drive slot; 18. fixing a rack; 19. a moving groove; 20. a drive block; 21. a drive gear; 22. a turntable; 23. a telescopic arm; 24. a telescopic groove; 25. a limiting groove; 26. a telescopic screw; 27. a telescopic rod.

Detailed Description

In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is further described below with reference to the specific embodiments and the attached drawings, but the following embodiments are only the preferred embodiments of the invention, and not all embodiments are provided. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention.

Referring to fig. 1-7, a 3D fluorescence tomography molecular image scanning device comprises a housing 1, a transparent placing mechanism disposed inside the housing 1 and provided with a scanning cavity 5, and a scanning mechanism disposed inside the scanning cavity 5 and sleeved above the placing mechanism, wherein the scanning mechanism comprises a lifting assembly disposed on the bottom wall of the scanning cavity 5, an adjusting assembly disposed on the lifting assembly, and a scanning element 9 disposed on the adjusting assembly;

the adjusting component comprises a lifting seat 8 and a moving part, wherein one end of the lifting seat is arranged on the lifting component through a rotating part, the end surface of the lifting seat is provided with a scanning port 16, the moving part is arranged on the wall of the opening of the scanning port 16 and moves on the wall of the opening, and the moving part is connected with the scanning part 9; the opening of the scanning port 16 is circular in shape.

As shown in fig. 1-7, the height of the scanning element 9 can be adjusted conveniently by the lifting assembly, and the moving element moving on the wall of the opening of the scanning opening 16 by the moving element can drive the scanning element 9 to move circumferentially in the scanning opening 16 on the lifting base 8, so that the scanning element 9 can be driven to scan the whole small living animal, and the scanning of the small living animal can be facilitated due to the fact that the scanning is inconvenient due to the fact that different directions and positions appear on the surface, and the accuracy of the scanning imaging details can be guaranteed.

A connecting port 2 and a heat dissipation port are formed in the side surface of the shell 1, and a lifting plate 3 which is movably connected is arranged in the connecting port 2; the opening of the heat dissipation port is provided with a heat dissipation plate 4, and the heat dissipation plate 4 is provided with a plurality of heat dissipation holes; the heat dissipation holes are provided with filter screens.

As shown in fig. 1-2, the lifting plate 3 can slide up and down to seal the connection port 2, and the heat generated inside the casing 1 can be dissipated through the heat dissipation port, so that the heat is prevented from accumulating inside the casing 1, and the scanning mechanism inside the casing 1 is prevented from being damaged.

The transparent placing mechanism comprises a rotary table 22 arranged on the bottom wall of the scanning cavity 5, a heightening piece 13 arranged on the rotary table 22 and a placing block 14 arranged on the heightening piece 13, a placing groove 15 is formed in the upper end face of the placing block 14, and the placing block 14 is made of transparent materials.

As shown in fig. 2, fig. 3 and fig. 6, the placing block 14 is made of a transparent material, so that when a living animal is placed on the placing block 14 for scanning, the situation that the placing block 14 blocks the animal is avoided, and incomplete scanning is avoided, wherein the turntable 22 is driven by an asynchronous stepping motor, so that the placing block 14 is driven to rotate together with the living animal on the placing block 14, and the small animal is scanned.

The height adjusting piece 13 comprises a telescopic arm 23, the bottom end of which is arranged on the turntable 22 and the end surface of the top end of which is provided with a telescopic groove 24, a telescopic screw rod 26, the bottom end of which is arranged in the telescopic groove 24 in a penetrating way, and a telescopic rod 27, the bottom end of which is arranged in the telescopic groove 24 in a penetrating way, the top end of which is connected with the placing block 14 and is sleeved on the telescopic screw rod 26, wherein the telescopic rod 27 is in threaded connection with the telescopic screw rod 26, the side surface of the telescopic rod 27 is provided with a limiting block, and the limiting block is arranged in a limiting groove 25 which is arranged on the inner wall of the telescopic groove 24 along the vertical direction; the telescopic rod 27 is made of transparent material.

As shown in fig. 6, wherein the telescopic rod 27 is made of transparent material and prevents the small animal from being scanned, so as to perform fine scanning on the whole small animal, wherein the bottom of the telescopic groove 24 is provided with a stepping motor connected with a telescopic screw 26, so as to control the distance between the placing block 14 and the bottom wall of the scanning cavity 5, and move in the limiting groove 25 through the limiting block, so as to ensure that the placing block 14 is stably lifted.

The lifting component comprises two lifting screw rods 6 vertically arranged on the bottom wall of the scanning cavity 5 and two lifting blocks 7 which are respectively sleeved on the different lifting screw rods 6 and are in threaded connection with the lifting screw rods 6, and the lifting blocks 7 are connected with the side surface of the lifting seat 8 through rotating parts.

The rotating part comprises two rotating rods, a rotating gear 12 and an adjusting motor 10, wherein one end of each rotating rod is arranged on the side face of the lifting seat 8, the other end of each rotating rod is connected with different lifting blocks 7, the rotating gear 12 is sleeved on one rotating rod, the adjusting motor 10 is arranged on the lifting block 7, the output end of the adjusting motor is connected with the adjusting gear 11, and the adjusting gear 11 is meshed with the rotating gear 12.

As shown in fig. 3, the adjusting motor 10 is also a stepping motor, so as to control the rotation angle and the forward rotation or reverse rotation of the lifting seat 8, so as to scan the whole body of the small animal through the scanning member 9 arranged on the lifting seat 8 by the moving member.

The lifting seat 8 is sleeved on the placing block 14 through a scanning port 16, and an annular driving groove 17 is formed in the wall of the opening of the scanning port 16; the moving member comprises a fixed rack 18 and a driving block 20 which are arranged on the bottom wall of the driving groove 17, and a driving gear 21 which is arranged on the driving block 20 and is meshed with the fixed rack 18, and the driving gear 21 is driven by a motor; the driving block 20 is connected with the scanning element 9.

As shown in fig. 1-7, by rotating the component and the driving component, the scanning component 9 can be driven to rotate around the small animal as the center in all directions, so that the whole body of the small animal can be scanned and imaged by the scanning component 9, the small animal in the living body can be scanned comprehensively, the imaging details of the small animal can be improved, the imaging details can be ensured, the structure is simple, the cost of the scanning device can be reduced, and the popularization and the use can be facilitated.

A moving groove 19 is formed on the side surface of the driving block 20, and a moving block connected with the driving block 20 is arranged in the moving groove 19.

As shown in fig. 6, in which the driving block 20 is stably moved in the driving groove 17 by stably sliding the moving block in the moving groove 19.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A3D fluorescence tomography animal molecule image scanning device comprises a shell (1), a transparent placing mechanism arranged in a scanning cavity (5) arranged in the shell (1), and a scanning mechanism arranged in the scanning cavity (5) and sleeved above the placing mechanism, and is characterized in that the scanning mechanism comprises a lifting component arranged on the bottom wall of the scanning cavity (5), an adjusting component arranged on the lifting component, and a scanning component (9) arranged on the adjusting component;

the adjusting assembly comprises a lifting seat (8) and a moving piece, wherein one end of the lifting seat is arranged on the lifting assembly through a rotating piece, the end face of the lifting seat is provided with a scanning port (16), the moving piece is arranged on the port wall of the scanning port (16) and moves on the port wall, and the moving piece is connected with the scanning piece (9); the opening of the scanning opening (16) is circular.

2. The 3D fluorescence tomography molecular image scanning apparatus of claim 1, wherein: a connecting port (2) and a heat dissipation port are formed in the side surface of the shell (1), and a lifting plate (3) which is movably connected is arranged in the connecting port (2); the opening of the heat dissipation port is provided with a heat dissipation plate (4), and the heat dissipation plate (4) is provided with a plurality of heat dissipation holes; and a filter screen is arranged on the heat dissipation holes.

3. The 3D fluorescence tomography molecular image scanning apparatus of claim 1, wherein: the transparent placing mechanism comprises a rotary table (22) arranged on the bottom wall of a scanning cavity (5), a height-adjusting piece (13) arranged on the rotary table (22) and a placing block (14) arranged on the height-adjusting piece (13), wherein a placing groove (15) is formed in the upper end face of the placing block (14), and the placing block (14) is made of transparent materials.

4. The 3D fluorescence tomography molecular image scanning device of claim 3, wherein: the height adjusting piece (13) comprises a telescopic arm (23) with a bottom end arranged on a rotary table (22) and a top end surface provided with a telescopic groove (24), a telescopic screw rod (26) with a bottom end penetrating through the telescopic groove (24), and a telescopic rod (27) with a bottom end penetrating through the telescopic groove (24), a top end connecting and placing block (14) and sleeved on the telescopic screw rod (26), wherein the telescopic rod (27) is in threaded connection with the telescopic screw rod (26), a limiting block is arranged on the side surface of the telescopic rod (27), and the limiting block is arranged in a limiting groove (25) formed in the inner wall of the telescopic groove (24) along the vertical direction; the telescopic rod (27) is made of transparent materials.

5. The 3D fluorescence tomography molecular image scanning device of claim 4, wherein: the lifting assembly comprises two lifting screw rods (6) vertically arranged on the bottom wall of the scanning cavity (5) and two lifting blocks (7) which are respectively sleeved on the lifting screw rods (6) and are in threaded connection with the lifting screw rods (6), and the lifting blocks (7) are connected with the side face of the lifting seat (8) through the rotating piece.

6. The 3D fluorescence tomography molecular image scanning device of claim 5, wherein: the rotating piece comprises two rotating rods, one of which is sleeved on the rotating rod of the lifting block (7), a rotating gear (12) on the rotating rod and an adjusting motor (10) which is arranged on the lifting block (7) and has an output end connected with an adjusting gear (11), wherein one end of each rotating rod is arranged on the side face of the lifting seat (8) and the other end of the side face of the lifting seat is connected with the other end of the lifting block (7), the adjusting gear (11) is meshed with the rotating gear (12).

7. The 3D fluorescence tomography molecular image scanning device of claim 6, wherein: the lifting seat (8) is sleeved on the placing block (14) through a scanning port (16), and an annular driving groove (17) is formed in the wall of the opening of the scanning port (16); the moving piece comprises a fixed rack (18) and a driving block (20) which are arranged on the bottom wall of the driving groove (17), and a driving gear (21) which is arranged on the driving block (20) and is meshed with the fixed rack (18), and the driving gear (21) is driven by a motor; the driving block (20) is connected with the scanning piece (9).

8. The 3D fluorescence tomography molecular image scanning apparatus of claim 7, wherein: a moving groove (19) is formed in the side face of the driving block (20), and a moving block connected with the driving block (20) is arranged in the moving groove (19).