CN114317239A - Method and device for adjusting gas concentration in incubator and incubator - Google Patents
Method and device for adjusting gas concentration in incubator and incubator Download PDFInfo
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- CN114317239A CN114317239A CN202111486895.0A CN202111486895A CN114317239A CN 114317239 A CN114317239 A CN 114317239A CN 202111486895 A CN202111486895 A CN 202111486895A CN 114317239 A CN114317239 A CN 114317239A
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 154
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 77
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 77
- 238000004422 calculation algorithm Methods 0.000 claims abstract description 54
- 230000001276 controlling effect Effects 0.000 claims description 11
- 230000001105 regulatory effect Effects 0.000 claims description 11
- 230000006870 function Effects 0.000 claims description 6
- 239000007789 gas Substances 0.000 description 139
- 238000004364 calculation method Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 11
- 238000007789 sealing Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 8
- 238000004891 communication Methods 0.000 description 6
- 241001125929 Trisopterus luscus Species 0.000 description 3
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- 238000005859 coupling reaction Methods 0.000 description 3
- 238000012258 culturing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/04—Apparatus for enzymology or microbiology with gas introduction means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
Abstract
The application relates to the technical field of biological medical treatment, and discloses a method for adjusting gas concentration in an incubator, which comprises the following steps: calculating the conduction time of the gas electromagnetic valve by adopting a PID control algorithm; compensating the conduction time by using the set gas leakage compensation value; and controlling the conduction of the gas electromagnetic valve according to the compensated conduction time so as to compensate the carbon dioxide leaked in the incubator. The influence of the tightness of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered. The incubator controls the on-off of the gas electromagnetic valve according to the compensated on-off duration, the influence of the tightness of the box body on the adjustment of the concentration of the carbon dioxide can be reduced, and the accuracy of the adjustment of the concentration of the carbon dioxide is improved. The application also discloses a device and incubator for adjusting gas concentration in the incubator.
Description
Technical Field
The present application relates to the field of biomedical technology, and for example, to a method and an apparatus for adjusting the gas concentration in an incubator, and an incubator.
Background
At present, a carbon dioxide incubator is a device for culturing cells/tissues in vitro by simulating and forming a growth environment similar to cells/tissues in an organism in an incubator body, is an advanced instrument for culturing cells, tissues and bacteria, and is key equipment necessary for developing immunology, oncology, genetics and biological engineering. The carbon dioxide incubator requires therefore, a precise adjustment of the concentration of carbon dioxide in the container for the cultivation of tissues and cells of the human body.
In the prior art, a carbon dioxide incubator is controlled by a PID (Proportion Integration, Differentiation) algorithm to adjust the concentration of carbon dioxide in the incubator body.
In the process of implementing the embodiments of the present disclosure, it is found that at least the following problems exist in the related art:
due to the limitation of the process level, the sealing performance of the box body of the carbon dioxide incubator cannot be hundreds of percent, and the carbon dioxide gas in the box body leaks to cause the concentration of the carbon dioxide in the box body to be reduced. Therefore, when the concentration of the carbon dioxide in the box body is adjusted through the PID control algorithm, errors can be generated due to the influence of the sealing performance of the box body, and the adjustment of the concentration of the carbon dioxide is not accurate enough.
Disclosure of Invention
The following presents a simplified summary in order to provide a basic understanding of some aspects of the disclosed embodiments. This summary is not an extensive overview nor is intended to identify key/critical elements or to delineate the scope of such embodiments but rather as a prelude to the more detailed description that is presented later.
The embodiment of the disclosure provides a method and a device for adjusting gas concentration in an incubator, and the incubator, so as to reduce the influence of the tightness of the incubator on the adjustment of carbon dioxide concentration and improve the accuracy of the adjustment of carbon dioxide concentration.
In some embodiments, the incubator comprises a pipeline for delivering carbon dioxide into the incubator and a gas solenoid valve for controlling the on-off of the pipeline, and the carbon dioxide is delivered into the incubator under the condition that the gas solenoid valve is switched on; the method comprises the following steps: calculating the conduction time of the gas electromagnetic valve by adopting a PID control algorithm; compensating the conduction time by using the set gas leakage compensation value; and controlling the conduction of the gas electromagnetic valve according to the compensated conduction time so as to compensate the carbon dioxide leaked in the incubator.
In some embodiments, the apparatus comprises: a processor and a memory storing program instructions, the processor being configured to, upon execution of the program instructions, perform the above-described method for adjusting a gas concentration within an incubator.
In some embodiments, the carbon dioxide incubator comprises: the system comprises a pipeline for conveying carbon dioxide into the incubator and a gas electromagnetic valve for controlling the on-off of the pipeline, wherein the carbon dioxide is conveyed into the incubator under the condition that the gas electromagnetic valve is conducted; and the device for adjusting the gas concentration in the incubator.
The method and the device for adjusting the gas concentration in the incubator and the carbon dioxide incubator provided by the embodiment of the disclosure can realize the following technical effects:
the incubator adopts a PID control algorithm to obtain the conduction time of the gas electromagnetic valve, and the conduction time is compensated through the set gas leakage compensation value to control the conduction of the gas electromagnetic valve, so that the carbon dioxide leaked in the incubator is compensated. The influence of the tightness of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered. The incubator controls the on-off of the gas electromagnetic valve according to the compensated on-off duration, the influence of the tightness of the box body on the adjustment of the concentration of the carbon dioxide can be reduced, and the accuracy of the adjustment of the concentration of the carbon dioxide is improved.
The foregoing general description and the following description are exemplary and explanatory only and are not restrictive of the application.
Drawings
One or more embodiments are illustrated by way of example in the accompanying drawings, which correspond to the accompanying drawings and not in limitation thereof, in which elements having the same reference numeral designations are shown as like elements and not in limitation thereof, and wherein:
FIG. 1 is a schematic diagram of a method for regulating gas concentration within an incubator according to embodiments of the present disclosure;
FIG. 2 is a schematic diagram of another method for regulating gas concentration within an incubator provided by embodiments of the present disclosure;
FIG. 3 is a schematic diagram of another method for regulating gas concentration within an incubator provided by embodiments of the present disclosure;
FIG. 4 is a schematic diagram of another method for regulating gas concentration within an incubator provided by embodiments of the present disclosure;
FIG. 5 is a schematic diagram of another method for regulating gas concentration within an incubator provided by embodiments of the present disclosure;
FIG. 6 is a schematic diagram of an apparatus for regulating the concentration of gases within an incubator according to embodiments of the present disclosure.
Detailed Description
So that the manner in which the features and elements of the disclosed embodiments can be understood in detail, a more particular description of the disclosed embodiments, briefly summarized above, may be had by reference to the embodiments, some of which are illustrated in the appended drawings. In the following description of the technology, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the disclosed embodiments. However, one or more embodiments may be practiced without these details. In other instances, well-known structures and devices may be shown in simplified form in order to simplify the drawing.
The terms "first," "second," and the like in the description and in the claims, and the above-described drawings of embodiments of the present disclosure, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the present disclosure described herein may be made. Furthermore, the terms "comprising" and "having," as well as any variations thereof, are intended to cover non-exclusive inclusions.
The term "plurality" means two or more unless otherwise specified.
In the embodiment of the present disclosure, the character "/" indicates that the preceding and following objects are in an or relationship. For example, A/B represents: a or B.
The term "and/or" is an associative relationship that describes objects, meaning that three relationships may exist. For example, a and/or B, represents: a or B, or A and B.
The term "correspond" may refer to an association or binding relationship, and a corresponds to B refers to an association or binding relationship between a and B.
The embodiment of the disclosure discloses an incubator, which comprises a pipeline for conveying carbon dioxide into the incubator and a gas electromagnetic valve for controlling the on-off of the pipeline, wherein the carbon dioxide is conveyed into the incubator under the condition that the gas electromagnetic valve is switched on.
Based on the structure of the incubator, and as shown in fig. 1, an embodiment of the present disclosure provides a method for adjusting a gas concentration in the incubator, including:
and S01, the incubator adopts a PID control algorithm to calculate the conduction time of the gas electromagnetic valve.
And S02, the incubator compensates the conduction time by the set gas leakage compensation value.
And S03, the incubator controls the conduction of the gas electromagnetic valve according to the compensated conduction time length so as to compensate the carbon dioxide leaked in the incubator.
By adopting the method for adjusting the concentration of the gas in the incubator, which is provided by the embodiment of the disclosure, the tightness of the incubator body of the incubator cannot be sealed by hundreds of percent due to the limitation of the process level, and the carbon dioxide gas in the incubator body can be slowly leaked usually, so that the concentration of the carbon dioxide in the incubator body is reduced. Therefore, when the concentration of the carbon dioxide in the box body is adjusted through the PID control algorithm, due to leakage of the carbon dioxide, the PID control algorithm generates errors during calculation, and therefore the output result is not matched with the actual situation of the incubator. Therefore, the incubator adopts a PID control algorithm to obtain the conduction time, and compensates the conduction time to control the on-off of the gas electromagnetic valve, thereby realizing the compensation of the carbon dioxide leaked in the incubator. The influence of the tightness of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered. The incubator controls the start and stop of the gas electromagnetic valve according to the compensated conduction time length, the influence of the tightness of the box body on the adjustment of the concentration of carbon dioxide can be reduced, and the accuracy of the adjustment of the concentration of carbon dioxide is improved. Alternatively, the gas leakage compensation value may be obtained according to the following manner: the incubator acquires the calculation period of the PID control algorithm and the working period of the gas solenoid valve; the incubator calculates the ratio of the working period to the calculation period; the incubator calculates the product of the ratio and the minimum precision of PID output; the product is determined as a gas leak compensation value. The minimum precision of the PID output is the minimum value of the opening time of the gas electromagnetic valve in the working period, which is output by the PID control algorithm.
Therefore, the compensation duration is determined by utilizing the calculation period and the working period, and the influence of the sealing performance of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered. The incubator controls the start and stop of the gas electromagnetic valve according to the compensated conduction time length, the influence of the tightness of the box body on the adjustment of the concentration of carbon dioxide can be reduced, and the accuracy of the adjustment of the concentration of carbon dioxide is improved.
In conjunction with fig. 2, an embodiment of the present disclosure provides a method for adjusting a gas concentration in an incubator, including:
and S01, the incubator adopts a PID control algorithm to calculate the conduction time of the gas electromagnetic valve.
And S21, the incubator acquires the gas leakage rate of the box body and sets a gas leakage compensation value according to the gas leakage rate.
And S02, the incubator compensates the conduction time by the set gas leakage compensation value.
And S03, the incubator controls the conduction of the gas electromagnetic valve according to the compensated conduction time length so as to compensate the carbon dioxide leaked in the incubator.
By adopting the method for adjusting the gas concentration in the incubator, provided by the embodiment of the disclosure, the incubator can determine the gas leakage compensation value according to the gas leakage rate, and then the conduction time calculated by the PID control algorithm is compensated through the gas leakage compensation value, so that the influence of the sealing property of the incubator body on the adjustment of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the adjustment of the carbon dioxide concentration is improved.
In conjunction with fig. 3, an embodiment of the present disclosure provides a method for adjusting a gas concentration in an incubator, including:
and S01, the incubator adopts a PID control algorithm to calculate the conduction time of the gas electromagnetic valve.
And S31, the incubator is used as a gas leakage compensation value according to the compensation value set by the user.
And S02, the incubator compensates the conduction time by the set gas leakage compensation value.
And S03, the incubator controls the conduction of the gas electromagnetic valve according to the compensated conduction time length so as to compensate the carbon dioxide leaked in the incubator.
By adopting the method for adjusting the gas concentration in the incubator provided by the embodiment of the disclosure, the incubator can compensate the conduction time calculated by the PID control algorithm through any set compensation value, and determine a gas leakage compensation value adapted to the actual situation according to the compensated carbon dioxide concentration curve, for example, the set compensation value can be the calculation period of the PID control algorithm. The incubator further compensates the conduction time calculated by the PID control algorithm through the gas leakage compensation value, the influence of the tightness of the incubator body on the adjustment of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the adjustment of the carbon dioxide concentration is improved.
In conjunction with fig. 4, an embodiment of the present disclosure provides a method for adjusting a gas concentration in an incubator, including:
and S01, the incubator adopts a PID control algorithm to calculate the conduction time of the gas electromagnetic valve.
S41, incubator calculated V ═ Δ c × V1/Tg.
S42, the incubator sets a gas leakage compensation value according to the gas leakage rate.
And S02, the incubator compensates the conduction time by the set gas leakage compensation value.
And S03, the incubator controls the conduction of the gas electromagnetic valve according to the compensated conduction time length so as to compensate the carbon dioxide leaked in the incubator.
Where V is the gas leakage rate, Δ c is the concentration percentage of gas leakage over time Tg, V1 is the volume of the tank, and Tg is the leakage time of the gas.
By adopting the method for adjusting the gas concentration in the incubator provided by the embodiment of the disclosure, the incubator can calculate the gas leakage rate according to the concentration difference of the gas in the leakage time. For example, a gas of a predetermined concentration, for example, carbon dioxide of 15% concentration is introduced into the box of the incubator. And then closing the air inlet valve, and detecting the residual concentration of the gas after a set time, so that the difference value between the set concentration and the residual concentration is the concentration percentage of gas leakage in the set time, and the gas leakage rate is obtained by multiplying the concentration percentage by the volume V1 of the box body and dividing the volume by the set time, wherein the leakage time is the set time. And determining a gas leakage compensation value according to the gas leakage rate. The influence of the sealing performance of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the regulation of the carbon dioxide concentration is improved.
Optionally, the incubator sets a gas leakage compensation value according to the gas leakage rate, including: the incubator acquires a working period set by the gas electromagnetic valve, and determines the volume of gas leaked in the working period according to the gas leakage rate and the working period; the incubator sets a gas leakage compensation value according to the volume of gas leaked in the working period.
Thus, the incubator can obtain the volume of gas leaked in the incubator body in the working period according to the gas leakage rate of the incubator body in unit time and the set working period of the gas electromagnetic valve. Thereby calculating a gas leakage compensation value in the basic duty cycle based on the gas volume.
Optionally, the incubator determines the volume of gas leaked during the work cycle according to the gas leakage rate and the work cycle, and comprises: incubator calculation V2 ═ V × T1; wherein, T1 is the working period set by the gas solenoid valve, and V2 is the gas volume leaked in the working period. In this way, the gas leak compensation value during a work cycle can be calculated from the volume of gas leaking during the work cycle. Optionally, the incubator sets a gas leakage compensation value according to a volume of gas leaked in a work cycle, including: the incubator calculates T2 ═ V2/Flow; wherein, T2 is the gas leakage compensation value, and Flow is the Flow rate of the gas solenoid valve.
Therefore, after the incubator obtains the volume of the gas leaked in the working period according to the gas leakage rate, the incubator divides the flow rate of the gas electromagnetic valve to obtain the opening time of the gas electromagnetic valve, and the result is the gas leakage compensation value. The PID control algorithm is compensated through the gas leakage compensation value, the influence of the sealing performance of the box body on the adjustment of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the adjustment of the carbon dioxide concentration is improved.
In conjunction with fig. 5, an embodiment of the present disclosure provides a method for adjusting a gas concentration in an incubator, including:
and S01, the incubator adopts a PID control algorithm to calculate the conduction time of the gas electromagnetic valve.
S51, the incubator calculates the sum of the gas leakage compensation value and the conduction time length, and determines the sum as the compensated conduction time length.
And S03, the incubator controls the conduction of the gas electromagnetic valve according to the compensated conduction time length so as to compensate the carbon dioxide leaked in the incubator.
By adopting the method for adjusting the gas concentration in the incubator, provided by the embodiment of the disclosure, the incubator can determine the gas leakage rate of the incubator body according to the gas leakage rate, and further determine the gas leakage compensation value according to the gas leakage rate and the flow of the gas electromagnetic valve. The influence of the sealing performance of the box body on the regulation of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the regulation of the carbon dioxide concentration is improved.
Optionally, the calculating, by the incubator, the conduction duration of the gas solenoid valve by using a PID control algorithm includes: incubator calculation Ek＝Set-Cur，delta＝Ek-Ek-1，Pout＝P×EkDout ═ D × delta, T2 ═ Pout + Dout; wherein E iskSetting an error value of a current calculation period, setting a Set concentration value, Cur a current concentration value, delta a change rate of the error, Ek-1For the error value of the previous calculation cycle, Pout is a proportional term, P is a proportional coefficient, Dout is a differential term, D is a differential coefficient, and T2 is the on-time.
And the current concentration value is the concentration of the carbon dioxide in the box body at the time point of calculation of the current calculation period by the PID control algorithm. The error value of the current calculation cycle is: the set concentration value minus the current concentration value. The error value of the last calculation cycle is: and subtracting the concentration value of the carbon dioxide in the box at the time point calculated by the PID control algorithm in the previous calculation period from the set concentration value.
Thus, the integral term is removed from the PID control algorithm in the above steps because the integral term of the PID control algorithm is used for eliminating the steady-state error of the system, and the integral term of the PID control algorithm is ineffective and can be ignored in a short time because the gas diffusion is fast and the response of the system is fast. The integral term is removed when the carbon dioxide concentration is adjusted by the PID control algorithm, so that the calculation pressure of the system is reduced. And the incubator determines a proportional term and a differential term of a PID control algorithm according to the current concentration value and the set concentration value of the carbon dioxide in the box body. The integral term of the traditional PID control algorithm is omitted, and the system pressure is relieved. The incubator calculates the sum of the proportional term, the differential term, and the gas leakage compensation value, and determines the sum as the on-time. The PID control algorithm is compensated through the gas leakage compensation value, the influence of the sealing performance of the box body on the adjustment of the carbon dioxide concentration by the PID control algorithm is fully considered, and the accuracy of the PID control algorithm on the adjustment of the carbon dioxide concentration is improved.
Optionally, the incubator controls the conduction of the gas solenoid valve according to the compensated conduction time to compensate the carbon dioxide leaked in the incubator, including: the incubator determines the conduction time as the working time of the gas electromagnetic valve; and the incubator controls the gas electromagnetic valve to operate according to the compensated conduction time length in the working period of the gas electromagnetic valve.
In this way, because the actuator of the incubator for adjusting the concentration of carbon dioxide is a gas solenoid valve, the conduction time of the PID control algorithm is the opening time of the gas solenoid valve in the current working cycle. The incubator determines the conduction time length as the working time length of the gas electromagnetic valve, and controls the running working time length of the gas electromagnetic valve in the working period of the gas electromagnetic valve. The PID control algorithm is compensated through the gas leakage compensation value, and the influence of the sealing performance of the box body on the adjustment of the carbon dioxide concentration by the PID control algorithm is fully considered. The opening duration of the gas electromagnetic valve in the current working period is matched with the actual concentration of the carbon dioxide in the box body and the sealing performance of the box body, and the accuracy of the PID control algorithm for adjusting the concentration of the carbon dioxide is improved. In the actual use process, the calculation period of the PID control algorithm of the incubator is far shorter than the working period of the gas electromagnetic valve. And in the working period, before the gas electromagnetic valve is opened, acquiring the conduction time calculated by the latest PID control algorithm, and controlling the gas electromagnetic valve to operate according to the compensated conduction time in the current working period according to the conduction time.
As shown in fig. 6, an embodiment of the present disclosure provides an apparatus for adjusting a gas concentration in an incubator, which includes a processor (processor)100 and a memory (memory) 101. Optionally, the apparatus may also include a Communication Interface (Communication Interface)102 and a bus 103. The processor 100, the communication interface 102, and the memory 101 may communicate with each other via a bus 103. The communication interface 102 may be used for information transfer. Processor 100 may invoke logic instructions in memory 101 to perform the method for regulating the concentration of gases within an incubator of the embodiments described above.
In addition, the logic instructions in the memory 101 may be implemented in the form of software functional units and stored in a computer readable storage medium when the logic instructions are sold or used as independent products.
The memory 101, which is a computer-readable storage medium, may be used for storing software programs, computer-executable programs, such as program instructions/modules corresponding to the methods in the embodiments of the present disclosure. The processor 100 executes functional applications and data processing, i.e. the method for regulating the gas concentration in an incubator in the above-described embodiments, by executing program instructions/modules stored in the memory 101.
The memory 101 may include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required for at least one function; the storage data area may store data created according to the use of the terminal device, and the like. In addition, the memory 101 may include a high-speed random access memory, and may also include a nonvolatile memory.
The embodiment of the disclosure provides an incubator, which comprises a pipeline for conveying carbon dioxide into the incubator and a gas electromagnetic valve for controlling the on-off of the pipeline, wherein the carbon dioxide is conveyed into the incubator under the condition that the gas electromagnetic valve is switched on; and the device for adjusting the gas concentration in the incubator.
Embodiments of the present disclosure provide a storage medium having stored thereon computer-executable instructions configured to perform the above-described method for adjusting a concentration of a gas within an incubator.
The storage medium may be a transitory storage medium or a non-transitory storage medium.
The technical solution of the embodiments of the present disclosure may be embodied in the form of a software product, where the computer software product is stored in a storage medium and includes one or more instructions to enable a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method of the embodiments of the present disclosure. And the aforementioned storage medium may be a non-transitory storage medium comprising: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes, and may also be a transient storage medium.
The above description and drawings sufficiently illustrate embodiments of the disclosure to enable those skilled in the art to practice them. Other embodiments may incorporate structural, logical, electrical, process, and other changes. The examples merely typify possible variations. Individual components and functions are optional unless explicitly required, and the sequence of operations may vary. Portions and features of some embodiments may be included in or substituted for those of others. Furthermore, the words used in the specification are words of description only and are not intended to limit the claims. As used in the description of the embodiments and the claims, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. Similarly, the term "and/or" as used in this application is meant to encompass any and all possible combinations of one or more of the associated listed. Furthermore, the terms "comprises" and/or "comprising," when used in this application, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. Without further limitation, an element defined by the phrase "comprising an …" does not exclude the presence of other like elements in a process, method or apparatus that comprises the element. In this document, each embodiment may be described with emphasis on differences from other embodiments, and the same and similar parts between the respective embodiments may be referred to each other. For methods, products, etc. of the embodiment disclosures, reference may be made to the description of the method section for relevance if it corresponds to the method section of the embodiment disclosure.
Those of skill in the art would appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software may depend upon the particular application and design constraints imposed on the solution. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the disclosed embodiments. It can be clearly understood by the skilled person that, for convenience and brevity of description, the specific working processes of the system, the apparatus and the unit described above may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.
In the embodiments disclosed herein, the disclosed methods, products (including but not limited to devices, apparatuses, etc.) may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units may be merely a logical division, and in actual implementation, there may be another division, for example, multiple units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form. The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to implement the present embodiment. In addition, functional units in the embodiments of the present disclosure may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit.
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. In the description corresponding to the flowcharts and block diagrams in the figures, operations or steps corresponding to different blocks may also occur in different orders than disclosed in the description, and sometimes there is no specific order between the different operations or steps. For example, two sequential operations or steps may in fact be executed substantially concurrently, or they may sometimes be executed in the reverse order, depending upon the functionality involved. Each block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations, can be implemented by special purpose hardware-based systems that perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
Claims (10)
1. A method for regulating the concentration of a gas in an incubator, the incubator comprising a conduit for delivering carbon dioxide into the incubator and a gas solenoid valve controlling the on/off of the conduit, the carbon dioxide being delivered into the incubator with the gas solenoid valve switched on, the method comprising:
calculating the conduction time of the gas electromagnetic valve by adopting a proportional-integral-derivative PID control algorithm;
compensating the conducting time by using a set gas leakage compensation value;
and controlling the conduction of the gas electromagnetic valve according to the compensated conduction time so as to compensate the carbon dioxide leaked in the incubator.
2. The method of claim 1, wherein the gas leak compensation value is set as follows:
acquiring a gas leakage rate of the box body, and setting a gas leakage compensation value according to the gas leakage rate; alternatively, the first and second electrodes may be,
and taking the compensation value set by the user as the gas leakage compensation value.
3. The method of claim 2, wherein obtaining a gas leak rate of the tank comprises:
calculating V ═ Δ c × V1/Tg;
where V is the gas leakage rate, Δ c is the concentration percentage of gas leakage over time Tg, V1 is the volume of the tank, and Tg is the leakage time of the gas.
4. The method of claim 2, wherein said setting the gas leak compensation value as a function of the gas leak rate comprises:
acquiring a working period set by the gas electromagnetic valve, and determining the volume of gas leaked in the working period according to the gas leakage rate and the working period;
and setting the gas leakage compensation value according to the volume of the leaked gas in the working period.
5. The method of claim 4, wherein said determining a volume of gas leaked during said duty cycle based on said gas leakage rate and said duty cycle comprises:
calculating V2 ═ V × T1;
wherein T1 is the working period set by the gas solenoid valve, and V2 is the gas volume leaked in the working period.
6. The method of claim 4, wherein said setting said gas leak compensation value based on a volume of gas leaked during said duty cycle comprises:
calculating T2 ═ V2/Flow;
wherein T2 is the gas leakage compensation value, and Flow is the Flow rate of the gas solenoid valve.
7. The method of claim 1, wherein the compensating the on-time with the set gas leakage compensation value comprises:
and calculating the sum of the gas leakage compensation value and the conduction time length, and determining the sum as the compensated conduction time length.
8. The method according to any one of claims 1 to 6, wherein the controlling of the conduction of the gas solenoid valve according to the compensated conduction time period to compensate for the carbon dioxide leaked in the incubator comprises:
determining the compensated conduction time length as the working time length of the gas electromagnetic valve;
and controlling the gas electromagnetic valve to operate according to the compensated conduction time length in the working period of the gas electromagnetic valve.
9. An apparatus for regulating the concentration of a gas within an incubator, comprising a processor and a memory storing program instructions, wherein the processor is configured to perform a method for regulating the concentration of a gas within an incubator according to any one of claims 1 to 8 when executing the program instructions.
10. A carbon dioxide incubator comprising a pipeline for delivering carbon dioxide into the incubator and a gas solenoid valve for controlling on/off of the pipeline, wherein carbon dioxide is delivered into the incubator when the gas solenoid valve is turned on, characterized by further comprising the apparatus for adjusting the gas concentration in the incubator according to claim 9.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111486895.0A CN114317239A (en) | 2021-12-07 | 2021-12-07 | Method and device for adjusting gas concentration in incubator and incubator |
| PCT/CN2022/109744 WO2023103422A1 (en) | 2021-12-07 | 2022-08-02 | Method and apparatus for adjusting gas concentration in incubator, and incubator |
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| CN202111486895.0A CN114317239A (en) | 2021-12-07 | 2021-12-07 | Method and device for adjusting gas concentration in incubator and incubator |
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| CN114317239A true CN114317239A (en) | 2022-04-12 |
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Cited By (2)
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| CN114717364A (en) * | 2022-04-18 | 2022-07-08 | 青岛海尔生物医疗科技有限公司 | Method and device for controlling three-gas incubator and three-gas incubator |
| WO2023103422A1 (en) * | 2021-12-07 | 2023-06-15 | 青岛海尔生物医疗科技有限公司 | Method and apparatus for adjusting gas concentration in incubator, and incubator |
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| Publication number | Publication date |
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| WO2023103422A1 (en) | 2023-06-15 |
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