CN114315595B - Preparation method of carbon-supported iron-based catalyst and application of intermediate synthesis of anticancer inhibitor of carbon-supported iron-based catalyst - Google Patents

Preparation method of carbon-supported iron-based catalyst and application of intermediate synthesis of anticancer inhibitor of carbon-supported iron-based catalyst Download PDF

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CN114315595B
CN114315595B CN202111439912.5A CN202111439912A CN114315595B CN 114315595 B CN114315595 B CN 114315595B CN 202111439912 A CN202111439912 A CN 202111439912A CN 114315595 B CN114315595 B CN 114315595B
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reaction
catalyst
ethanol
iron
based catalyst
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CN114315595A (en
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邱仁华
李定中
李铖汉
阳天宝
路浩
张文胜
尹双凤
神户宣明
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Aurisco Pharmaceutical Co ltd
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Abstract

The invention aims to provide a preparation method of a carbon-supported iron-based catalyst and application of an anticancer inhibitor intermediate thereof in synthesis. According to the method, the prepared monoatomic iron-based carbon doped material is used as a catalyst, hydrazine hydrate is used as a hydrogen source, and the key intermediate is synthesized by reacting in solvents such as methanol, ethanol, isopropanol and the like under mild conditions with high yield. The method has the following advantages: the high-purity target product can be obtained only by suction filtration and washing, the solvent can be recycled, and the catalyst can be reused for ten times after being washed, dried and activated by the solvent. The preparation method of the catalyst has the advantages of simple process, environment friendliness, high efficiency, low cost, good functional group compatibility and simple post-treatment, and has potential value of industrial production.

Description

Preparation method of carbon-supported iron-based catalyst and application of intermediate synthesis of anticancer inhibitor of carbon-supported iron-based catalyst
[ field of technology ]
The invention relates to a novel synthesis method of an iron-based carbon supported catalyst and application thereof in synthesis of an anticancer drug intermediate, belonging to the field of medicine catalytic synthesis. The catalyst has simple preparation process and mild condition, and the catalyst is used in reducing nitro group as intermediate of anticancer medicine into amino compound.
[ background Art ]
Amino compounds are important fine chemical intermediates, and can be widely applied to the fields of pesticides, organic functional materials, medicines and the like. The main method for synthesizing the organic amine compound is to reduce the nitro compound into amino compound, and the most widely used method at present is to reduce the nitro compound into amine compound: iron and hydrazine. For example: iron, calcium chloride and hydrazine systems, ferric trichloride and hydrazine systems, ferric hydroxide oxide, polymer and hydrazine systems, nano-ferric oxide and hydrazine systems, and iron carbon doped and hydrazine systems. The above method for nitroreduction has many problems, a large amount of byproduct iron black is produced, the post-treatment is complex, the yield is low, the reaction time is long, the tolerance of functional groups is poor, the environmental pollution is large, and the preparation of the catalyst is complex. In addition, palladium carbon hydrogenation reduction, the reaction process needs a specially-made high-pressure resistant reaction kettle, has high equipment requirements and has great potential safety hazard. Iron is an element which is green, environment-friendly, cheap and necessary for human body, and is one of the metal elements with highest content on the earth. Based on the background, a large amount of literature researches prove that the novel synthesis method of the iron-based carbon-supported single-atom catalyst is prepared, the preparation process of the catalyst is simple, the condition is mild, the catalyst is applied to the synthesis of a plurality of key anticancer drug intermediates, and the method adopts cheap and easily available industrial charcoal as a catalyst raw material. Research shows that the catalyst can reduce nitro compound into amine compound in high yield, and the catalyst may be reused ten times after being re-activated through simple filtering and solvent washing, and the catalyst has high catalytic activity. At present, no published literature and patent application about a single-atom catalyst for iron-doped carbon nitration reduction exist at home and abroad.
[ invention ]
The invention aims to provide a novel preparation method of an iron and carbon supported catalyst, which is applied to the synthesis of key intermediates of anticancer drugs such as the anticancer drugs of octreotide, gefitinib, afatinib, imatinib, AMG510, dacatinib, ceritinib, lapatinib, apatinib and the like. The synthesis method takes the iron-based carbon negative material prepared by us as a catalyst, takes hydrazine hydrate as a hydrogen source, and synthesizes a key intermediate in high yield through mild reaction in solvents such as methanol, ethanol, isopropanol and the like. The target product is obtained by simple filtration, solvent washing and high purity recovery of the solvent, and the catalyst can be reused for ten times after solvent washing, drying and activation. The method is characterized in that: the synthesized iron-based carbon carrier is used as a catalyst, the nitrobenzene derivative I is used as a reaction raw material, the reaction is effectively carried out in an alcohol solvent at 60-100 ℃, and the aminobenzene derivative II can be obtained within 2-8 h.
Wherein said R is 1 、R 2 、R 3 、R 4 、R 5 Is a functional group such as hydrogen, hydroxyl, fluorine, chlorine, bromine, methyl, ethyl, cyano, hydroxyl, amide, tert-butyl, phenyl, etc.
In the synthesis method, the dosage of the iron catalyst is 0.1 equivalent, and the alcohol is a solvent; the reaction time is 2-8h, and the reaction temperature is-25 ℃ to 85 ℃.
The synthesis method for reducing nitro-synthetic ammonia compounds by using the iron-carbon doped single-atom catalyst opens up a new low-cost green path, and has the advantages that: the yield of the target product is high, the reaction condition is mild, and the reaction operation is simple.
[ description of the drawings ]
Fig. 1 is a route diagram of the carbon-supported iron-based catalyst prepared by the invention applied to synthesis of a key anticancer drug intermediate, fig. 2 is an EDXmapping imaging diagram of the carbon-supported iron-based catalyst, and fig. 3 is an AC-TEM imaging diagram of the carbon-supported iron-based catalyst.
[ detailed description ] of the invention
According to the invention, ferric chloride hexahydrate (270 g,1 mol) is dissolved in 1000-2000ml of water, activated carbon (1200 g,10 mol) is added, the temperature is raised to 60-100 ℃, 50% sodium hydroxide solution (160-200 g,4-5 mol) is slowly added dropwise, stirring is carried out for 1-5h at 60-100 ℃, stirring and cooling are carried out to room temperature, stirring is carried out overnight, filtering is carried out, and washing is carried out. And drying at 60-400 ℃ for 12-24 hours to obtain 1300g of carbon-supported iron-based catalyst. Then 0.1mol of the iron-based supported catalyst is added into 1mol of nitrobenzene derivative, dissolved in 2-3L of alcohol solution, and reacted for 2-8 hours at the temperature of 60-100 ℃ to obtain the target aniline compound. The invention is further illustrated below in connection with specific preparations:
example 1:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 =ethyl, R 1 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 =ethyl, R 1 ＝R 3 ＝R 4 ＝R 5 ) The yield is 98%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 2:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 ，R 3 Methyl, R 1 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 ，R 3 Methyl, R 1 ＝R 4 ＝R 5 =h), yield 95%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 3:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 Methyl, R 2 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 Methyl, R 2 ＝R 3 ＝R 4 ＝R 5 =h), yield 96%, purity greater than 99%, catalyst 80-200 ℃ dryActivated overnight and reused. Example 4:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 =chloro, R 4 Methyl, R 2 ＝R 3 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 =chloro, R 4 Methyl, R 2 ＝R 3 ＝R 5 =h), yield 90%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 5:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 =fluoro, R 2 Methyl, R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 =fluoro, R 2 Methyl, R 3 ＝R 4 ＝R 5 =h), yield 91%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 6:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 =chloro, R 2 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 =chloro, R 2 ＝R 3 ＝R 4 ＝R 5 =h), yield 93%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 7:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 3 =chloro, R 1 ＝R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 3 =chloro, R 1 ＝R 2 ＝R 4 ＝R 5 =h), yield 95%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 8:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 =fluoro, R 1 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 =fluoro, R 1 ＝R 3 ＝R 4 ＝R 5 =h), yield 94%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 9:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 =bromine, R 2 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 =bromine, R 2 ＝R 3 ＝R 4 ＝R 5 =h), yield 87%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 10:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 3 =bromine, R 1 ＝R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, hot filtering, washing with ethanol, and recovering solvent to obtain white solid aniline derivativeBiological II (R) 3 =bromine, R 1 ＝R 2 ＝R 4 ＝R 5 =h), yield 86%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 11:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 =bromine, R 4 =trifluoromethyl, R 1 ＝R 3 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 =bromine, R 4 =trifluoromethyl, R 1 ＝R 3 ＝R 5 =h), yield 86%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 12:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 Methyl, R 3 =fluoro, R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 Methyl, R 3 =fluoro, R 2 ＝R 4 ＝R 5 =h), yield 46%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 13:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 3 Amino group, R 1 ＝R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 3 Amino group, R 1 ＝R 2 ＝R 4 ＝R 5 =h), yield 91%, purity greater than 99%, catalyst 80-200 ℃ dried overnightActivating and reusing.
Example 14:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 Amino group, R 1 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 Amino group, R 1 ＝R 3 ＝R 4 ＝R 5 =h), yield 91%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 15:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 Ethyl alcohol, R 1 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 Ethyl alcohol, R 1 ＝R 3 ＝R 4 ＝R 5 =h), yield 80%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 16:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 1 =hydroxy, R 2 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 1 =hydroxy, R 2 ＝R 3 ＝R 4 ＝R 5 =h), yield 93%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 17:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 3 =amide, R 1 ＝R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 3 =amide, R 1 ＝R 2 ＝R 4 ＝R 5 =h), yield 93%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 18:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 2 Methyl formate, R 1 ＝R 3 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 2 Methyl formate, R 1 ＝R 3 ＝R 4 ＝R 5 =h), yield 96%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 19:
nitrobenzene derivative I (R) was charged into a 5L reaction flask 3 Acetylene group, R 1 ＝R 2 ＝R 4 ＝R 5 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative II (R) 3 Acetylene group, R 1 ＝R 2 ＝R 4 ＝R 5 =h), yield 90%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 20:
1mol of nitrobenzene derivative 3-nitro-5-fluoropyridine and 0.1mol of iron-based catalyst and 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 3-amino-5-fluoropyridine, the yield is 91 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 21:
1mol of nitrobenzene derivative 2-nitro-3-hydroxy-5-bromopyridine and 0.1mol of iron-based catalyst, 2-3L ethanol are added into a 5L reaction flask, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 2-amino-3-hydroxy-5-bromopyridine, the yield is 92%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 22:
1mol of nitrobenzene derivative 7-fluoro-6-nitroquinolin-2- (1H) -one and 0.1mol of iron-based catalyst, 2-3L ethanol were added to a 5L reaction flask, and the reaction was stirred at 60-70℃for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 7-fluoro-6-aminoquinoline-2- (1 hydrogen) -ketone, the yield is 81 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 23:
1mol of nitrobenzene derivative 7-chloro-8-nitroquinoline and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 7-chloro-8-aminoquinoline, the yield is 81 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 24:
1mol of nitrobenzene derivative 5-nitrobenzimidazole and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 5-aminobenzimidazole, the yield is 88 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 25:
1mol of nitrobenzene derivative 4-nitroindole and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 4-aminoindole, the yield is 89%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 26:
1mol of nitrobenzene derivative 5-nitroindole and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative 5-aminoindole, the yield is 88 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 27:
1mol of nitrobenzene derivative 7-nitroindole and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain the white solid aniline derivative 7-aminoindole, the yield is 86 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 28:
1mol of 2-isopropoxy-5-methyl-4- (pyridin-4-yl) nitrobenzene and 0.1mol of iron-based catalyst, 2-3L ethanol are added into a 5L reaction flask, the reaction is stirred at 60-70 ℃ for 2-8h and followed by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 2-isopropoxy-5-methyl-4- (pyridine-4-yl) aniline, the yield is 86 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 29:
into a 5L reaction flask was charged (S) -N 4 - (3-chloro-4-fluorophenyl) -6-nitro-7- ((tetrahydrofuran-3-yl) oxy) quinazolin-4-amine 1mol and iron-based catalysisThe reaction was stirred at 60-70℃for 2-8h with 0.1mol of 2-3L ethanol and was followed by TLC until completion. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid (S) -N 4 - (3-chloro-4-fluorophenyl) -7- ((tetrahydrofuran-3-yl) oxy) quinazoline-4, 6-diamine, the yield is 86%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 30:
n was added to a 5L reaction flask 1 - (2- (dimethylamino) ethyl) -5-methoxy-N 1 -methyl-N 4 - (4- (1-methyl-1H-indol-3-yl) pyrimidin-2-yl) -2-nitrobenzene-1, 4-diamine 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 60-70℃for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid N 1 - (2- (dimethylamino) ethyl) -5-methoxy-N 1 -methyl-N 4 - (4- (1-methyl-1H-indol-3-yl) pyrimidine-2-yl) benzene-1, 2, 4-triamine has the yield of 92%, the purity of more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 31:
1mol of N- (4-fluoro-2-methoxy-5-nitrophenyl) -4- (1-methyl-1H-indol-3-yl) pyrimidine-2-amine and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8H, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid N- (4-fluoro-2-methoxy-5-aminophenyl) -4- (1-methyl-1H-indol-3-yl) pyrimidine-2-amine, the yield is 92 percent, the purity is more than 99 percent, and the catalyst is dried and activated at 80-200 ℃ for repeated use.
Example 32:
1mol of 4-methoxy-5- (3-morpholinopropoxy) -2-nitrobenzonitrile and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 2-amino-4-methoxy-5- (3-morpholinopropoxy) benzonitrile, the yield is 89%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 33:
1mol of 1- (4-nitrophenyl) cyclopentane-1-carbonitrile and 0.1mol of iron-based catalyst, 2-3L of ethanol were added to a 5L reaction flask, and the reaction was stirred at 60-70℃for 2-8 hours and followed by TLC until completion. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 1- (4-aminophenyl) cyclopentane-1-carbonitrile, the yield is 94 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 34:
1mol of 2-chloro-4-methyl-3-nitropyridine and 0.1mol of iron-based catalyst, 2-3L of ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 2-chloro-4-methylpyridine-3-amine, the yield is 91 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 35:
in a 5L reaction flask was added 1mol of 2-chloro-1- ((3-fluorobenzyl) oxy) -4-nitrobenzene and 0.1mol of iron-based catalyst, 2-3L ethanol, and the reaction was stirred at 60-70℃for 2-8h and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 2-chloro-1- ((3-fluorobenzyl) oxy) -4-aniline, the yield is 89%, the purity is more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 36:
1mol of N- (3-chloro-4-fluorophenyl) -7-methoxy-6-nitroquinazolin-4-amine and 0.1mol of iron-based catalyst, 2-3L ethanol are added into a 5L reaction bottle, the reaction is stirred at 60-70 ℃ for 2-8h, and the reaction is tracked by TLC until the reaction is complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid N- (3-chloro-4-fluorophenyl) -7-methoxy quinazoline-4, 6-diamine, the yield is 93 percent, the purity is more than 99 percent, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 37:
adding N-' into a 5L reaction bottle1mol of 2-methyl-5-nitrophenyl) -4- (pyridin-3-yl) pyrimidin-2-amine and 0.1mol of iron-based catalyst, 2-3L ethanol were reacted at 60-70℃with stirring for 2-8h and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid 6-methyl-N 1 - (4- (pyridine-3-yl) pyrimidine-2-yl) benzene-1, 3-diamine has the yield of 96%, the purity of more than 99%, and the catalyst is dried and activated overnight at 80-200 ℃ and is reused.
Example 38:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 Amino group, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 2 Amino group, R 1 ＝R 3 ＝R 4 =h), yield 94%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 39:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 ＝R 2 Methyl, R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 1 ＝R 2 Methyl, R 3 ＝R 4 =h), yield 96%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 40:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 Methyl, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 2 Methyl, R 1 ＝R 3 ＝R 4 =h), yield 97%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 41:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =methoxy, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 2 =methoxy, R 1 ＝R 3 ＝R 4 =h), yield 90%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 42:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =hydroxy, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 2 =hydroxy, R 1 ＝R 3 ＝R 4 =h), yield 89%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 43:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 ＝R 2 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 1 ＝R 2 ＝R 3 ＝R 4 =h), yield 76%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 44:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 Amino group, R 2 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 1 Amino group, R 2 ＝R 3 ＝R 4 =h), yield 93%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 45:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 =bromine, R 2 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at 75-85 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid aniline derivative IV (R) 1 =bromine, R 2 ＝R 3 ＝R 4 =h), yield 95%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 46:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =chloro, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 2 =chloro, R 1 ＝R 3 ＝R 4 =h), yield 96%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 47:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 =fluoro, R 2 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 1 =fluoro, R 2 ＝R 3 ＝R 4 =h), yield 96%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 48:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 Cyano, R 2 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 1 Cyano, R 2 ＝R 3 ＝R 4 =h), yield 90%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 49:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =chloro, R 4 =fluoro, R 1 ＝R 3 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 2 =chloro, R 4 =fluoro, R 1 ＝R 3 =h), yield 91%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 50:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 =fluoro, R 2 =chloro, R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 1 =fluoro, R 2 =chloro, R 3 ＝R 4 =h), yield 89%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 51:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =bromine, R 4 =fluorine，R 1 ＝R 3 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 2 =bromine, R 4 =fluoro, R 1 ＝R 3 =h), yield 89%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
Example 52:
A5L reaction flask was charged with nitrobenzene derivative III (R 2 =bromine, R 1 ＝R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 2 =bromine, R 1 ＝R 3 ＝R 4 =h), yield 92%, purity greater than 99%, catalyst 80-200 ℃ dried overnight for activation, and repeated use.
Example 53:
A5L reaction flask was charged with nitrobenzene derivative III (R 1 ＝R 2 =fluoro, R 3 ＝R 4 =h) 1mol and iron-based catalyst 0.1mol,2-3L ethanol, the reaction was stirred at-25 ℃ to 25 ℃ for 2-8H and followed by TLC until the reaction was complete. After the reaction is finished, the mixture is filtered by heat, washed by ethanol and the solvent is recovered to obtain white solid phenylhydrazine derivative V (R) 1 ＝R 2 =fluoro, R 3 ＝R 4 =h), yield 93%, purity greater than 99%, catalyst dried overnight at 80-200 ℃ for activation, and repeated use.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims (2)

1. The application of the carbon-supported iron-based catalyst in preparing phenylhydrazine derivative V is characterized in that the carbon-supported iron-based catalyst is prepared by the following preparation method:
dissolving 270g of ferric chloride hexahydrate and 1mol in 1000-2000ml of water, adding 1200g of active carbon and 10mol, heating to 60-100 ℃, slowly dripping 160-200g of 50% sodium hydroxide solution and 4-5mol, stirring for 1-5h at 60-100 ℃, stirring and cooling to room temperature, stirring overnight, filtering and washing, drying at 60-400 ℃ for 12-24h to obtain 1300g of carbon-supported iron-based catalyst,
the method for preparing phenylhydrazine derivative V comprises the following steps: adding 0.1mol of the carbon-supported iron-based catalyst into 1mol of nitrobenzene derivative III, dissolving in 2-3L of alcohol solution, and reacting for 2-8 hours in the presence of hydrazine hydrate at the temperature of minus 25-25 ℃ to obtain phenylhydrazine derivative V, wherein the reaction formula is as follows:
wherein said R is 1 、R 2 、R 3 、R 4 Each independently is fluorine, chlorine, bromine, cyano.
2. The use of the carbon-supported iron-based catalyst according to claim 1 for the preparation of phenylhydrazine derivatives V, wherein the carbon-supported iron-based catalyst is reusable.
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