CN114306944A - Portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease - Google Patents
Portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease Download PDFInfo
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- CN114306944A CN114306944A CN202210071287.1A CN202210071287A CN114306944A CN 114306944 A CN114306944 A CN 114306944A CN 202210071287 A CN202210071287 A CN 202210071287A CN 114306944 A CN114306944 A CN 114306944A
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Abstract
The invention provides a portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease, which is head-mounted and comprises a magnetic field coil, a coil bracket, an LED light source, a light source bracket, a bracket shaft, a power supply and signal two-in-one line, a rechargeable power supply, a master controller, a magnetic field coil driver and an LED light source driver. The device can generate a pulse magnetic field and a pulse optical signal with the frequency of 4Hz to 90Hz, can tune and enhance the gamma frequency band and the theta frequency band of the brain wave of the Alzheimer's disease patient, can simultaneously regulate and control the neural excitability of different functional brain areas of the temporal lobe and the occipital lobe by simultaneously carrying out magnetic stimulation and optical stimulation, synergistically enhance the neural activity of the cognitive related multifunctional brain areas based on the neural plasticity and the neural network interaction of the functional brain areas, and realize the function of improving the learning and memory cognitive abilities of the patient. The device of the invention has the appearance similar to an earphone, is small and portable, is convenient for a patient to wear, does not influence the daily action of the patient, and can realize two treatment modes of hospitalization and household.
Description
Technical Field
The invention relates to the technical field of nerve regulation and control technology, magnetic stimulation technology, optical stimulation technology and medical equipment, in particular to a portable magneto-optical stimulation device, and particularly relates to a rehabilitation assistive device for improving cognitive impairment of patients with Alzheimer's disease.
Background
Research shows that the inside of the brain of an Alzheimer disease patient can generate A beta amyloid accumulation, and the clinic treatment mostly adopts medicaments, but the effect is not obvious and adverse reactions occur. In addition, the gamma band (30-80Hz) of the brain waves of the Alzheimer's disease patients is damaged, and the gamma band is proved to be closely related to the cognitive functions of the brain, such as learning and memory. Another study showed that administering transcranial electrical stimulation in the theta range (4-8Hz) to patients with Alzheimer's disease also improved the cognitive impairment symptoms of the patients.
The gamma frequency band of the Alzheimer's brain wave can be successfully activated by external multi-physical factor stimulation, such as optical signals, acoustic signals and magnetic fields, so that the accumulation of Abeta amyloid can be slowed down, and the corresponding brain cognitive functions of learning, memory and the like are improved. However, most of the existing auxiliary devices are single magnetic stimulation (such as transcranial magnetic stimulation) or acousto-optic stimulation, and are mostly gamma frequency bands, and no portable device with both magnetic stimulation and optical stimulation exists, the frequency covers the gamma frequency band and the theta frequency band, the requirement of a patient for simultaneously using the two physical factors for stimulation anytime and anywhere is met, and the treatment effect is improved.
Disclosure of Invention
In order to solve the technical problems, the invention provides a portable magneto-optical stimulation device for improving cognitive impairment of Alzheimer's disease, which has the following specific technical scheme:
the invention discloses a portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease, which comprises a magnetic field coil, an LED light source, a coil bracket, a light source bracket, a bracket shaft, a power supply, a signal two-in-one line and a power supply driving device, wherein the power supply is connected with the coil bracket through a power supply line; the magnetic field coil consists of a pair of circular Helmholtz coils and is arranged on the coil bracket; the LED light source is arranged on the light source bracket; the light source bracket is connected with the coil bracket into a whole through the bracket shaft; the light source bracket can freely rotate and position over the head of a user and in front of eyes through the bracket shaft, so that the light source bracket is convenient to wear and use; the power supply driving equipment comprises a rechargeable power supply, a master controller, a magnetic field coil driver and an LED light source driver, and is connected with the magnetic field coil and the LED light source through a power supply and signal combined line; the magnetic field coil generates a pulse magnetic field with adjustable frequency from 4Hz to 90Hz, and the LED light source generates pulse light signals with adjustable frequency from 4Hz to 90 Hz.
Furthermore, the coil size of the magnetic field coil covers the ear and the nearby area of the user, and the distance between the pair of circular Helmholtz coils is 120mm-180mm and is adjustable; the coil support is soft material to the distance between a pair of circular helmholtz coils is adjusted, thereby is fit for all kinds of crowds and uses.
Furthermore, the LED light source is provided with two rows of LED lamp beads, each row is provided with a plurality of LED lamp beads, and the two rows of LED lamp beads are vertically arranged on the light source bracket; the LED lamp beads are low-power patch lamp beads.
Further, the light source support is made of soft materials and is adjusted together with the coil support, so that the LED lamp is suitable for different people.
Furthermore, the power supply and the signal can be freely extended and retracted between 80cm and 150cm, so that the use requirements of people with different heights can be met.
Furthermore, the coil support and the light source support are made of soft plastics of polyamide, polyformaldehyde, polycarbonate, thermoplastic polyester, ultra-high molecular weight polyethylene or vinyl alcohol copolymer, and the coil support and the light source support are of hollow structures, so that power lines and signal lines can be conveniently arranged.
Furthermore, the magnetic field coil driver consists of a square wave signal generator and an IGBT power tube, the square wave signal generator generates a square wave signal with adjustable frequency, and the IGBT power tube is driven to convert an input direct current electric signal into a pulse signal with adjustable amplitude and frequency; the pulse signal is used for driving the magnetic field coil to generate a pulse magnetic field with adjustable frequency, the frequency range is 4-90Hz, and the amplitude is 0-5 mT.
Further, the LED light source driver comprises time base integrated circuit, resistance and electric capacity, time base integrated circuit produces frequency adjustable pulse signal, through resistance and electric capacity release give the LED light source produces frequency adjustable pulse light signal, pulse light signal's frequency range is 4-90Hz, and the intensity of light is felt according to the user and is adjusted the power.
Furthermore, the master controller is a single chip microcomputer which independently controls the frequency, amplitude and on-off of the magnetic field coil driver and also independently controls the frequency, light intensity and on-off of the LED light source driver; different combined treatment modes are generated by carrying out time sequence control on the overall controller.
Further, the combined treatment mode includes single θ frequency range pulsed magnetic stimulation, single γ frequency range pulsed magnetic stimulation, single θ frequency range pulsed light stimulation, single γ frequency range pulsed light stimulation, simultaneous θ frequency range pulsed magnetic stimulation and θ frequency range pulsed light stimulation, simultaneous θ frequency range pulsed magnetic stimulation and γ frequency range pulsed light stimulation, simultaneous γ frequency range pulsed magnetic stimulation and θ frequency range pulsed light stimulation, simultaneous γ frequency range pulsed magnetic stimulation and γ frequency range pulsed light stimulation, alternating θ frequency range pulsed magnetic stimulation and θ frequency range pulsed light stimulation, alternating θ frequency range pulsed magnetic stimulation and γ frequency range pulsed light stimulation, alternating γ frequency range pulsed magnetic stimulation and θ frequency range pulsed light stimulation, and alternating γ frequency range pulsed magnetic stimulation and γ frequency range pulsed light stimulation.
Has the advantages that:
the invention realizes real-time pulse magnetic stimulation and pulse light stimulation in a head-wearing mode. The design frequency is 4Hz-90Hz, the stimulation requirements of a gamma frequency band and a theta frequency band are met, and the gamma frequency band and the theta frequency band of the brain waves of the Alzheimer's disease patient can be tuned and enhanced. Compared with a single magnetic stimulation or light stimulation device, the device can simultaneously regulate and control the nerve excitability of different functional brain areas of the temporal lobe and the occipital lobe by simultaneously carrying out magnetic stimulation and light stimulation, and can synergistically enhance the cognitive-related multifunctional brain area nerve activity and improve the memory and cognitive ability of the Alzheimer disease patient based on the neural plasticity and the neural network interaction of the functional brain areas. The device of the invention is similar to an earphone in appearance, is small and portable, is convenient for a patient to wear, does not influence the daily action of the patient, can realize two treatment modes of hospitalization and household, and has important industrial economic value and scientific and technological application value.
Drawings
Figure 1 is a diagram of a model of the portable magneto-optical stimulation device of the present invention;
fig. 2 is a control schematic diagram of the portable magneto-optical stimulation device of the present invention;
figure 3 is a schematic view of the wearing of the portable magneto-optical stimulation device of the present invention;
fig. 4 is a detailed view of the light emitting portion of the portable magneto-optical stimulation device of the present invention.
In the figure: the LED lamp comprises a magnetic field coil 1, an LED light source 2, a coil support 3, a light source support 4, a support shaft 5, a power supply and signal doubling line 6, a rechargeable power supply 7, a master controller 8, a magnetic field coil driver 9 and an LED light source driver 10.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Specific implementations of the present invention are further described below in conjunction with the following figures:
the invention provides a portable magneto-optical stimulation device for improving cognitive impairment of Alzheimer's disease based on the basic principle that Alzheimer's disease patients can activate gamma frequency bands and theta frequency bands for enhancing brain waves under exogenous physical stimulation of different frequencies so as to improve cognitive impairment, which mainly comprises: the device comprises a magnetic field coil 1, an LED light source 2, a coil support 3, a light source support 4, a support shaft 5, a power supply and signal doubling-up line 6, a rechargeable power supply 7, a master controller 8, a magnetic field coil driver 9 and an LED light source driver 10. The appearance of portable magneto-optical stimulation device is similar to an earphone, is small and exquisite and light, is convenient for a patient to wear, does not influence the daily action of the patient, and can realize two treatment modes of hospitalization and household.
The model diagram of the portable magneto-optical stimulation device is shown in fig. 1, the magnetic field coil 1 is composed of a pair of circular helmholtz coils with the diameter of 80mm, the pair of circular helmholtz coils is installed on the coil support 3 and is positioned at two sides of the head of a user close to ears, and the distance between the two coils is adjustable within the range of 120mm-180 mm. The LED light source 2 is provided with two rows of LED lamp beads, each row is provided with 10LED lamp beads, the LED lamp beads are arranged on the light source support 4 and are arranged up and down, and the distance between the LED lamp beads and the light source support is 4cm, as shown in figure 4. The LED lamp bead is made of a patch type 3020UCWC cold white light, the working current is 20mA, the light emitting angle is 120 degrees, and the brightness is 5-7 LM. The light source support 4 is connected with the coil support 3 into a whole through the support shaft 5. Through the support shaft 5, the light source support 4 can be freely rotated and positioned right above the head and in front of the eyes of the user, and is convenient to wear and use, as shown in fig. 3. The power supply driving equipment mainly comprises a rechargeable power supply 7, a master controller 8, a magnetic field coil driver 9 and an LED light source driver 10, and is connected with the magnetic field coil 1 and the LED light source 2 through the power supply and signal two-in-one line 6. The telescopic length of the power supply and signal two-in-one line 6 is 80cm to 150 cm.
The control schematic diagram of the portable magneto-optical stimulation device is shown in fig. 2, the rechargeable power supply 7 is connected with the master controller 8, the master controller 8 is connected with the magnetic field coil driver 9 and the LED light source driver 10, the magnetic field coil 1 is connected with the magnetic field coil driver 9, and the LED light source 2 is connected with the LED light source driver 10. The magnetic field coil driver 9 is controlled by the master controller 8, so that the frequency of the pulse magnetic field is adjustable within the range of 4Hz to 90Hz, the main working frequency is theta frequency band or gamma frequency band, and the magnetic field intensity is 0-5 mT. The master controller 8 controls the LED light source driver 10, so that the frequency of the pulse light source is adjustable within the range of 4Hz to 90Hz, and the light intensity is adjustable. The rechargeable power supply 7 is a lithium ion battery, the master controller 8 is a single chip microcomputer, the magnetic field coil driver 9 is composed of a square wave signal generator and an IGBT power tube, and the LED light source driver 10 is composed of a time base integrated circuit NE555 and a resistor capacitor.
In actual use, as shown in fig. 3, the light source holder 4 and the coil holder 3 of the portable magneto-optical stimulation device are rotatably overlapped on the head in a first step; the second step is to rotate the light source holder 4 via the holder shaft 5 so that the LED light source 2 is in front of the user's eyes. Thirdly, the portable magneto-optical stimulation device can be started through the master controller 8, and the frequency and the size of a pulse magnetic field and a pulse light source are controlled; fourthly, multiple stimulation modes can be selected through the master controller 8, including independent theta frequency range pulse magnetic stimulation, independent gamma frequency range pulse magnetic stimulation, independent theta frequency range pulse optical stimulation, independent gamma frequency range pulse optical stimulation, synchronous theta frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, synchronous theta frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, synchronous gamma frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, synchronous gamma frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, alternate theta frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, alternate theta frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, alternate gamma frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, and the 12 stimulation modes are provided. After the stimulation is finished, the power supply is turned off through the master controller 8, and the head-wearing part is taken down. The applicable modes of different Alzheimer disease patients are explored through multiple stimulation modes, and the learning and memory cognitive ability of the Alzheimer disease patients is improved.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and the preferred embodiments are not exhaustive and do not limit the invention to the precise embodiments described. Various modifications and improvements of the technical solution of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solution of the present invention is to be covered by the protection scope defined by the claims.
Claims (10)
1. A portable magneto-optical stimulation device for ameliorating cognitive impairment in alzheimer's disease, characterized by: the LED lamp comprises a magnetic field coil, an LED light source, a coil bracket, a light source bracket, a bracket shaft, a power supply and signal combined line and power supply driving equipment; the magnetic field coil consists of a pair of circular Helmholtz coils and is arranged on the coil bracket; the LED light source is arranged on the light source bracket; the light source bracket is connected with the coil bracket into a whole through the bracket shaft; the light source bracket can freely rotate and position over the head of a user and in front of eyes through the bracket shaft, so that the light source bracket is convenient to wear and use; the power supply driving equipment comprises a rechargeable power supply, a master controller, a magnetic field coil driver and an LED light source driver, and is connected with the magnetic field coil and the LED light source through a power supply and signal combined line; the magnetic field coil generates a pulse magnetic field with adjustable frequency from 4Hz to 90Hz, and the LED light source generates pulse light signals with adjustable frequency from 4Hz to 90 Hz.
2. A portable magneto-optical stimulation device according to claim 1, characterized in that: the size of the coil of the magnetic field coil covers the ear and the nearby area of a user, and the distance between the pair of circular Helmholtz coils is 120-180 mm and can be adjusted; the coil support is soft material to the distance between a pair of circular helmholtz coils is adjusted, thereby is fit for all kinds of crowds and uses.
3. A portable magneto-optical stimulation device according to claim 1, characterized in that: the LED light source is provided with two rows of LED lamp beads, each row is provided with a plurality of LED lamp beads, and the two rows of LED lamp beads are vertically arranged on the light source bracket; the LED lamp beads are low-power patch lamp beads.
4. A portable magneto-optical stimulation device according to claim 2, characterized in that: the light source support is made of soft materials and is adjusted together with the coil support, so that the LED lamp is suitable for different people.
5. A portable magneto-optical stimulation device according to claim 1, characterized in that: the power supply and the signal are combined into a line, the length of the power supply and the signal can be freely extended and retracted between 80cm and 150cm, and the use requirements of people with different heights can be met.
6. A portable magneto-optical stimulation device according to claim 4, characterized in that: the coil support and the light source support are made of soft plastics selected from polyamide, polyformaldehyde, polycarbonate, thermoplastic polyester, ultra-high molecular weight polyethylene or vinyl alcohol copolymer, and the coil support and the light source support are of hollow structures, so that power lines and signal lines can be conveniently arranged.
7. A portable magneto-optical stimulation device according to claim 1, characterized in that: the magnetic field coil driver consists of a square wave signal generator and an IGBT power tube, the square wave signal generator generates a square wave signal with adjustable frequency, and the IGBT power tube is driven to convert an input direct current electric signal into a pulse signal with adjustable amplitude and frequency; the pulse signal is used for driving the magnetic field coil to generate a pulse magnetic field with adjustable frequency, the frequency range is 4-90Hz, and the amplitude is 0-5 mT.
8. A portable magneto-optical stimulation device according to claim 1, characterized in that: the LED light source driver comprises time base integrated circuit, resistance and electric capacity, time base integrated circuit produces frequency adjustable pulse signal, through resistance and electric capacity release give the LED light source produces frequency adjustable pulse light signal, pulse light signal's frequency range is 4-90Hz, and the intensity of light is felt according to the user and is adjusted the power.
9. A portable magneto-optical stimulation device according to claim 1, characterized in that: the master controller is a single chip microcomputer which independently controls the frequency, amplitude and on-off of the magnetic field coil driver and also independently controls the frequency, light intensity and on-off of the LED light source driver; different combined treatment modes are generated by carrying out time sequence control on the overall controller.
10. A portable magneto-optical stimulation device according to claim 9, characterized in that: the combined treatment mode comprises independent theta frequency range pulse magnetic stimulation, independent gamma frequency range pulse magnetic stimulation, independent theta frequency range pulse optical stimulation, independent gamma frequency range pulse optical stimulation, synchronous theta frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, synchronous theta frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, synchronous gamma frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, synchronous gamma frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, alternate theta frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, alternate theta frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation, alternate gamma frequency range pulse magnetic stimulation and theta frequency range pulse optical stimulation, and alternate gamma frequency range pulse magnetic stimulation and gamma frequency range pulse optical stimulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210071287.1A CN114306944A (en) | 2022-01-21 | 2022-01-21 | Portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease |
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| CN202210071287.1A CN114306944A (en) | 2022-01-21 | 2022-01-21 | Portable magneto-optical stimulation device for improving cognitive impairment caused by Alzheimer's disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115006681A (en) * | 2022-06-05 | 2022-09-06 | 上海中医药大学 | Flashing light stimulation nerve regulation and control device capable of flexibly regulating parameters |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115006681A (en) * | 2022-06-05 | 2022-09-06 | 上海中医药大学 | Flashing light stimulation nerve regulation and control device capable of flexibly regulating parameters |
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