CN114306936A

CN114306936A - Programmable device and implantable neurostimulation system

Info

Publication number: CN114306936A
Application number: CN202210089774.0A
Authority: CN
Inventors: 马艳
Original assignee: Sceneray Co Ltd
Current assignee: Sceneray Co Ltd
Priority date: 2022-01-25
Filing date: 2022-01-25
Publication date: 2022-04-12
Also published as: WO2023142534A1

Abstract

A programming device and an implantable neurostimulation system are provided, the implantable neurostimulation system comprising the programming device disposed outside a patient and a stimulator implanted in the patient; the programming device is communicatively connected with the stimulator, the programming device including a controller; the controller is configured to: receiving a sliding operation by using a touch screen, and responding to the sliding operation to acquire timing information of a stimulation program, wherein the stimulation program is used for indicating an identification and a parameter value of a stimulation parameter of the stimulator, and the timing information is used for indicating a starting time and an ending time; and generating a control instruction based on the stimulation program and timing information thereof, and sending the control instruction to the stimulator so as to enable the stimulator to generate and apply electrical stimulation to the target tissue of the patient according to the control instruction. The program control equipment can meet different stimulation requirements of different patients, and is wide in application range and better in user experience.

Description

Programmable device and implantable neurostimulation system

Technical Field

The present application relates to the field of implantable medical device technology, and more particularly, to a programmable device and an implantable neurostimulation system.

Background

The implanted nerve stimulation system mainly comprises a stimulator implanted in a body and a program control device in vitro. The nerve regulation and control technology is mainly characterized in that electrodes are implanted into a specific structure (namely a target point) in a body through a stereotactic operation, and a stimulator implanted into the body of a patient sends electric pulses to the target point through the electrodes to regulate and control the electric activities and functions of corresponding nerve structures and networks, so that symptoms are improved, and pain is relieved.

The existing program control equipment is not humanized enough in the aspect of timing stimulation, and generally speaking, the stimulation time corresponding to the stimulation program is set by a manufacturer and cannot be adjusted. For example: 8 points in the morning to 8 points in the evening correspond to the stimulation program with larger stimulation pulse amplitude, and the rest of the time is automatically switched to the stimulation program with smaller stimulation pulse amplitude.

The program control equipment has the defects that a user cannot set stimulation time corresponding to a stimulation program independently, different stimulation requirements of different patients cannot be met, the use is not flexible, and the user experience is poor.

Disclosure of Invention

The application aims to provide a program-controlled device and an implantable nerve stimulation system, different stimulation requirements of different patients are met, the application range is wide, and the user experience is better.

The purpose of the application is realized by adopting the following technical scheme:

in a first aspect, the present application provides a programming device for use in an implantable neurostimulation system, which includes the programming device disposed outside a patient and a stimulator implanted in the patient;

the programming device is communicatively connected with the stimulator, the programming device including a controller;

the controller is configured to:

receiving a sliding operation by using a touch screen, and responding to the sliding operation to acquire timing information of a stimulation program, wherein the stimulation program is used for indicating an identification and a parameter value of a stimulation parameter of the stimulator, and the timing information is used for indicating a starting time and an ending time;

and generating a control instruction based on the stimulation program and timing information thereof, and sending the control instruction to the stimulator so as to enable the stimulator to generate and apply electrical stimulation to the target tissue of the patient according to the control instruction.

The technical scheme has the beneficial effects that: on one hand, a user can flexibly set timing information corresponding to a stimulation program, and compared with a program control device with nonadjustable timing information, the program control device can meet different stimulation requirements of different patients, and is wide in application range and better in user experience; on the other hand, the user can set the timing information through sliding operation, and compared with a mode of gradually adjusting through key operation and a mode of directly inputting a specific numerical value, the operation steps of the user are greatly reduced, so that the setting of the timing information is faster and more convenient, and the use experience of the user is further improved.

In some optional embodiments, the controller is configured to acquire timing information of the stimulation program in the following manner:

receiving the sliding operation by using the touch screen, and responding to the sliding operation to acquire timing information of a target program control mode, wherein the target program control mode is used for indicating at least one stimulation program;

timing information for each of the stimulation programs is determined based on the target programming mode and its timing information.

The technical scheme has the beneficial effects that: the target program control mode can indicate one or more stimulation programs, and a user can synchronously set the timing information of the multiple stimulation programs by setting the timing information of the target program control mode, so that the requirements of different patients in practical application are met.

In some optional embodiments, the controller is further configured to obtain timing information for each of the stimulation programs as follows:

when the target programming mode indicates a single stimulation program, determining timing information of the target programming mode as timing information of the single stimulation program;

when the target programming mode indicates a plurality of stimulation programs, timing information for each of the stimulation programs is determined based on timing information for the target programming mode, a duration of each of the stimulation programs, and a ranking of the plurality of stimulation programs.

The technical scheme has the beneficial effects that: when the target program control mode indicates a single stimulation program, the provided electrical stimulation is in a single form in a time period corresponding to the timing information of the target program control mode; when the target programming mode indicates a plurality of stimulation programs, electrical stimulation performed in sequence using the plurality of stimulation programs may be provided within a time period corresponding to the timing information of the target programming mode.

In some optional embodiments, the controller is further configured to:

when a first time period corresponding to the timing information of the target program control mode is overlapped with a second time period corresponding to the preset timing information of the existing program control mode, determining an overlapping time period;

and when the coincidence time period is detected to be part of the second time period, removing the coincidence time period from the second time period to obtain a remaining time period, and updating the timing information of the existing program control mode by using the remaining time period.

The technical scheme has the beneficial effects that: when the timing information of the target program control mode conflicts with the previously set timing information of the existing program control mode, the second time period corresponding to the timing information of the existing program control mode is deduplicated with the timing information of the target program control mode as the standard, the timing information of the existing program control mode is updated, the timing information of the target program control mode is not changed, the adjustment intention of the user can be reflected, and the use preference of the user is met.

In some optional embodiments, the controller is further configured to:

and when the coincidence time period is detected to be the whole second time period, removing the timing information of the existing program control mode.

The technical scheme has the beneficial effects that: when the coincidence time period is all of the second time period, the timing information of the existing program control mode can be removed, and the program control mode corresponding to the second time period is changed from the existing program control mode to the target program control mode.

In some optional embodiments, the controller is further configured to:

displaying a dial plate by using the touch screen, and displaying two sliding blocks which can slide in the circumferential direction of the dial plate, wherein the positions of the two sliding blocks are respectively used for indicating the starting time and the ending time corresponding to the target program control mode;

the sliding operation is an operation of sliding one slider or an operation of sliding two sliders.

The technical scheme has the beneficial effects that: through setting up dial plate and slider, the start time can be reflected through the position of slider on the dial plate clearly directly perceivedly with the end moment, and the user of being convenient for sets up timing information.

In some optional embodiments, the controller is further configured to obtain timing information of the target programming mode by:

respectively detecting whether the operation of sliding each sliding block is effective or not so as to obtain effective operation in the sliding operation;

and acquiring timing information of the target program control mode based on the effective operation.

The technical scheme has the beneficial effects that: the sliding operation can be an operation of sliding one sliding block or an operation of sliding two sliding blocks, and when a user slides one sliding block and the operation of sliding the sliding block is judged to be effective, the timing information of the target program control mode is acquired according to the position of the sliding block; when the user slides the two sliders, as long as the operation of sliding one of the sliders or the two sliders is judged to be effective, the timing information of the target program control mode is acquired according to the position of the slider corresponding to the effective operation.

That is to say, no matter slide a slider or slide two sliders, as long as there is effective operation, just can acquire the timing information of target programme-controlled mode, reduced the operation degree of difficulty that the user regularly set up, to the user that hand controllability is relatively poor, especially parkinson patient, when sliding two sliders, even only the operation of sliding one of them slider is judged effective, also can set up timing information, can give positive feedback to the user from this, alleviate user's psychological burden greatly, promote user's use experience.

and respectively detecting whether the operation of sliding each sliding block is effective, and acquiring the timing information of the target program control mode when the operation of sliding each sliding block is effective.

The technical scheme has the beneficial effects that: when a user slides a slider and the operation of sliding the slider is judged to be effective, acquiring timing information of a target program control mode according to the position of the slider; when the user slides the two sliders, only the operation of sliding the two sliders is judged to be effective, and the timing information of the target program control mode is acquired according to the positions of the two sliders.

That is, regardless of whether one slider is slid or two sliders are slid, the timing information of the target program control mode is acquired only when the operations corresponding to all the slid sliders are valid, and when the user slides two sliders and only one of the slid operations is determined to be valid, the timing information cannot be set. To patients such as depression, bipolar disorder, the action of making impulsion, not mentality easily, the programme-controlled equipment of this application has certain threshold in timing information's setting, only the user can set up timing information in the stable operation under the state of wisdom, cool and quiet to guarantee user's life safety, simultaneously, to personnel of using programme-controlled equipment unintentionally such as children, only by the gliding operation that all sliders correspond when all effective, just acquire the timing information of target programme-controlled mode, can further avoid the maloperation.

In some alternative embodiments, with one of the sliders being slid as the target slider, the process of detecting whether the operation of sliding the target slider is valid is as follows:

acquiring a sliding path corresponding to the target slider based on the operation of sliding the target slider, and detecting whether the positions of all track points of the sliding path are in a preset sliding area;

when the position of at least one track point of the sliding path is not in the preset sliding area, determining that the operation of sliding the target sliding block is invalid;

and when the positions of all track points of the sliding path are in the preset sliding area, determining that the operation of sliding the target sliding block is effective.

The technical scheme has the beneficial effects that: whether the operation of the sliding target slider is effective or not is judged by detecting the positions of the track points of the sliding path, and the operation of the sliding target slider is determined to be effective only when the positions of the track points are in a preset sliding area, so that timing information is acquired, and therefore misoperation of a user can be avoided.

In some optional embodiments, the controller is further configured to detect whether an operation of sliding the target slider is effective in the following manner:

when the positions of all track points of the sliding path are in the preset sliding area, acquiring a reference path corresponding to the sliding path based on a starting point, an end point and a path direction of the sliding path, wherein the reference path is a part of a preset circular path, the path direction of the reference path is determined by the path direction of the sliding path, and the preset circular path is in the preset sliding area;

detecting whether the similarity of the sliding path and the reference path is not smaller than a preset similarity threshold value;

when the similarity is smaller than the preset similarity threshold, determining that the operation of sliding the target slider is invalid;

and when the similarity is not smaller than the preset similarity threshold, determining that the operation of sliding the target slider is effective.

The technical scheme has the beneficial effects that: the method comprises the steps of judging whether sliding operation is effective or not by using a detection process in two stages, acquiring timing information of a target program control mode only when the sliding operation is judged to be effective, when the position of each track point of a sliding path is detected to be in a preset sliding area in the first stage, not directly determining that the sliding operation is effective, but entering detection in the second stage, determining that the sliding operation is effective when the similarity is detected to be not smaller than a preset similarity threshold value, and further acquiring the timing information.

Specifically, in the first stage, detecting whether the positions of the track points of the sliding path are all in a preset sliding region, when detecting that the positions of the track points of the sliding path are all in the preset sliding region, indicating that a user may have an intention of setting timing information, and then entering the second stage; in the second stage, based on the starting point, the end point and the path direction of the sliding path, a reference path corresponding to the sliding path is obtained, the similarity between the sliding path and the reference path is obtained, whether the similarity is not smaller than a preset similarity threshold value or not is detected, and when the similarity is not smaller than the preset similarity threshold value, it can be determined that the sliding operation is not a misoperation, and the sliding operation is effective.

The effectiveness judgment result obtained through the detection processes of the two stages is not the final purpose, and the final purpose is to judge the real intention of the user operation according to the effectiveness judgment result, so that the set timing information accords with the psychological expectation of the user, and the use experience of the user is improved.

In some optional embodiments, the controller is further configured to obtain the reference path by:

finding a point which is closest to the starting point of the sliding path on the preset circular path to serve as the starting point of the reference path;

finding a point which is closest to the end point of the sliding path on the preset circular path to serve as the end point of the reference path;

taking a path between a starting point and an end point of the reference path from the preset circular path as the reference path based on the path direction of the sliding path.

The technical scheme has the beneficial effects that: the method comprises the steps of taking a point, closest to a starting point of a sliding path, on a preset circular path as the starting point of a reference path, taking a point, closest to an end point of the sliding path, on the preset circular path as the end point of the reference path, and intercepting a path, from the starting point to the end point of the reference path, in the preset circular path along the path direction of the sliding path as the reference path, so that the obtained reference path is more attached to the sliding path, and the corresponding timing information is more reasonable to obtain according to the reference path, and the intention of a user in setting the timing information can be truly reflected.

In some optional embodiments, the two sliders include a start slider for indicating a start time and an end slider for indicating an end time;

and a vector pointing to the starting sliding block from the center of the dial plate is used as a first vector, a vector pointing to the ending sliding block from the center of the dial plate is used as a second vector, and an included angle from the first vector to the second vector along the clockwise direction of the dial plate is not more than 180 degrees.

The technical scheme has the beneficial effects that: and selecting the clockwise direction of the dial as the extending direction from the starting time to the ending time, wherein the time period from the starting time to the ending time does not exceed the time period corresponding to a half dial.

For example: the time period of one circle around the dial is set as 24 hours, and when the corresponding time of the positions of the two sliders is 23: 00 and 1: 00, determine 23: the slider corresponding to 00 is a starting slider, 1: the slider corresponding to 00 is the end slider, and the time period determined thereby is 23: 00 to 1 of the following day: 00(2 hours duration), rather than 1: 00 to 23 of the day: 00 (time duration is 22 hours), which is more suitable for the operation habit of the user.

In some optional embodiments, the controller is further configured to:

displaying clock information of the stimulator and clock information of the programmable device by using the touch screen;

and receiving synchronous operation by using the touch screen, and responding to the synchronous operation to synchronously process the clock information of the stimulator and the clock information of the program control equipment.

The technical scheme has the beneficial effects that: by synchronously processing the clock information of the stimulator and the clock information of the program control equipment, the deviation of the setting of the timing information caused by the asynchronization of the clock information of the stimulator and the program control equipment can be avoided.

In some optional embodiments, the controller is further configured to:

acquiring a first corresponding relation between the disease type and a preset duration;

determining a preset time length corresponding to the patient based on the disease type of the patient and the first corresponding relation;

and prompting the user to operate again when detecting that the duration corresponding to the timing information of the target program control mode is longer than the preset duration corresponding to the patient.

The technical scheme has the beneficial effects that: the time length allowed by the patients with different disease types to receive stimulation is different, and the corresponding preset time length is determined according to the disease types of the patients, so that the timing information can only be set within the range allowed by the corresponding preset time length, and the life safety of the patients is guaranteed.

In some optional embodiments, the controller is further configured to:

acquiring a second corresponding relation between the disease type and a preset tissue;

and acquiring a preset tissue corresponding to the disease type of the patient as a target tissue corresponding to the patient based on the disease type of the patient and the second corresponding relation.

The technical scheme has the beneficial effects that: the body tissues stimulated by patients with different disease types are different, and the corresponding target tissues are determined according to the disease types of the patients, so that the electrical stimulation is applied to the target tissues of the patients in a targeted manner, and the requirements of practical application are met.

In some alternative embodiments, the stimulation parameter is one or more of a pulse width parameter, an amplitude parameter, and a frequency parameter of the voltage.

The technical scheme has the beneficial effects that: the target parameter can be any one of a pulse width parameter, an amplitude parameter and a frequency parameter of the voltage, so that the program control device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter, and the requirements of practical application are met.

In some alternative embodiments, the patient's disease type comprises one or more of epilepsy, tremor, parkinson's disease, depression, obsessive compulsive disorder, alzheimer's disease, and drug addiction.

The technical scheme has the beneficial effects that: the program control equipment can be used for controlling stimulators in patients with different disease types, and the application range is wide.

In some optional embodiments, the programming device further comprises the touch screen and a communication module, and the controller is electrically connected with the touch screen and the communication module respectively;

the touch screen is configured to receive user operations, and the communication module is configured to enable data interaction between the programming device and the stimulator.

The technical scheme has the beneficial effects that: the touch screen and the communication module can be arranged on the program control equipment, so that the program control equipment has a man-machine interaction function and a communication function.

In some alternative embodiments, the implantable neurostimulation system comprises the programming device disposed outside of a patient and a stimulator implanted within the patient;

the stimulator is configured to generate and apply electrical stimulation to target tissue of the patient;

the programming device is communicatively connected with the stimulator, the programming device including a controller:

the controller is configured to:

and generating a control instruction based on the stimulation program and the timing information thereof, and sending the control instruction to the stimulator.

The technical scheme has the beneficial effects that: the implantable nerve stimulation system can meet different stimulation requirements of different patients, has wide application range and better use experience of users; and the user can set the timing information through sliding operation, and compared with a mode of gradually adjusting through key operation and a mode of directly inputting a specific numerical value, the operation steps of the user are greatly reduced, so that the setting of the timing information is faster and more convenient, and the use experience of the user is further improved.

Drawings

The present application is further described below with reference to the drawings and examples.

Fig. 1 is a schematic flowchart of a control method of a program control device according to an embodiment of the present disclosure;

fig. 2 is a schematic flowchart of acquiring timing information of a stimulation program according to an embodiment of the present disclosure;

fig. 3 is a partial schematic flowchart of a control method of a program control device according to an embodiment of the present application;

fig. 4 is a partial schematic flow chart of a control method of another programmable device according to an embodiment of the present application;

FIG. 5 is a schematic diagram of a display interface of a touch screen provided in an embodiment of the present application;

fig. 6 is a schematic flowchart illustrating a process of obtaining timing information of a target program control mode according to an embodiment of the present application;

FIG. 7 is a schematic flowchart illustrating a process of detecting whether a sliding operation is valid according to an embodiment of the present disclosure;

FIG. 8 is a schematic flow chart of another method for detecting whether a sliding operation is effective according to an embodiment of the present disclosure;

fig. 9 is a schematic flowchart of acquiring a reference path according to an embodiment of the present application;

FIG. 10 is a schematic flowchart of another method for obtaining configuration parameter values of a target parameter according to an embodiment of the present disclosure;

fig. 11 is a block diagram of a program control device according to an embodiment of the present disclosure;

fig. 12 is a block diagram of an implantable neurostimulation system according to an embodiment of the present disclosure.

Detailed Description

The present application is further described with reference to the accompanying drawings and the detailed description, and it should be noted that, in the present application, the embodiments or technical features described below may be arbitrarily combined to form a new embodiment without conflict.

Referring to fig. 1, an embodiment of the present application provides a control method of a programming device, which is applied to an implantable neurostimulation system, where the implantable neurostimulation system includes the programming device disposed outside a patient and a stimulator implanted in the patient;

the programming device is communicatively coupled with the stimulator.

The method comprises a step S101 to a step S102.

Step S101: receiving a sliding operation by using a touch screen, and responding to the sliding operation to acquire timing information of a stimulation program, wherein the stimulation program is used for indicating an identification and a parameter value of a stimulation parameter of the stimulator, and the timing information is used for indicating a starting time and an ending time;

step S102: and generating a control instruction based on the stimulation program and timing information thereof, and sending the control instruction to the stimulator so as to enable the stimulator to generate and apply electrical stimulation to the target tissue of the patient according to the control instruction.

In some embodiments, obtaining timing information for a stimulation program may be setting timing information for a stimulation program for which timing information has not been set (e.g., a newly added stimulation program).

In other embodiments, obtaining timing information for a stimulation program may be a modification of the timing information for a stimulation program for which timing information has been set. In some embodiments, the stimulation parameters of the stimulation program can be adjusted at any time, and the parameter values of the stimulation parameters corresponding to the stimulation program can be set or modified (by using a touch screen).

Therefore, on one hand, a user can flexibly set timing information corresponding to a stimulation program, and compared with a program control device with nonadjustable timing information, the program control device can meet different stimulation requirements of different patients, and is wide in application range and better in user experience; on the other hand, the user can set the timing information through sliding operation, and compared with a mode of gradually adjusting through key operation and a mode of directly inputting a specific numerical value, the operation steps of the user are greatly reduced, so that the setting of the timing information is faster and more convenient, and the use experience of the user is further improved.

The stimulator may be any one of an Implantable nerve electrical stimulation device, an Implantable cardiac electrical stimulation System (also called cardiac pacemaker), an Implantable Drug Delivery System (I DDS for short), and a lead switching device. Examples of the implantable neural electrical Stimulation device include Deep Brain Stimulation (DBS), Cortical Brain Stimulation (CNS), Spinal Cord Stimulation (SCS), Sacral Nerve Stimulation (SNS), and Vagal Nerve Stimulation (VNS). The stimulator is disposed within the patient for providing electrical stimulation.

Programmed devices may include, but are not limited to: smart phones (such as Android phones, iOS phones, etc.), tablet computers, portable personal computers, Mobile Internet Devices (MID), and other Devices, which are not limited in the embodiments of the present application.

In some optional embodiments, the programming device may further include the touch screen and a communication module.

Therefore, the touch screen and the communication module can be arranged on the program control equipment, so that the program control equipment has a man-machine interaction function and a communication function.

In some embodiments, the programming device may include a physician programming device and/or a patient programming device.

The patient programming device is provided for the patient, who can use the patient programming device to adjust the stimulation parameters of the corresponding stimulator. Specifically, a corresponding preset adjustment range may be set based on the disease information of the patient, and the patient may only adjust the stimulation parameters of the corresponding stimulator within the corresponding preset adjustment range.

The doctor program control equipment is equipped for doctors, and one doctor program control equipment can utilize the communication module to respectively carry out data interaction with stimulators of a plurality of patients.

In some implementations, the communication module may include a wired communication module and/or a wireless communication module.

The wired communication module may include one or more of a fiber optic communication unit, a coaxial cable communication unit, an open wire communication unit, a waveguide communication unit, and an opto-electronic communication unit; the wireless communication module may include one or more of a 4G communication unit, a 5G communication unit, a WIFI communication unit, a near field communication unit, a WiGig communication unit, a bluetooth communication unit, a ZigBee communication unit, a microwave communication unit, a satellite communication unit, and an atmospheric laser communication unit.

The wired communication module is stable, and has high reliability and high transmission rate; the wireless communication module has longer communication distance, is not limited by wires, has certain mobility, can communicate through wireless connection in a mobile state, and has lower cost.

In some embodiments, the touch screen may include any one of a resistive touch screen, a capacitive touch screen, and a surface acoustic wave screen.

In some alternative embodiments, the stimulation parameter may be one or more of a pulse width parameter, an amplitude parameter, and a frequency parameter of the voltage.

Therefore, the target parameter can be any one of a pulse width parameter, an amplitude parameter and a frequency parameter of the voltage, so that the program control device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter, and the requirements of practical application are met.

In some embodiments, the stimulation parameters may also include one or more of stimulation pattern, energy output pattern.

The stimulation mode is used for indicating monopolar stimulation or multipolar stimulation, and the energy output mode is used for indicating constant voltage stimulation or constant current stimulation.

Constant voltage stimulation, namely the output voltage is fixed and unchanged, and the current changes along with the change of the resistance; constant current stimulation, namely output current is constant, and voltage changes along with the change of resistance.

Referring to fig. 2, in some alternative embodiments, the step S101 may include steps S201 to S202.

Step S201: receiving the sliding operation by using the touch screen, and responding to the sliding operation to acquire timing information of a target program control mode, wherein the target program control mode is used for indicating at least one stimulation program;

step S202: timing information for each of the stimulation programs is determined based on the target programming mode and its timing information.

The number of stimulation programs indicated by the target programming mode is not limited in the present application, and may be 1, 3, 6 or 8.

Therefore, the target program control mode can indicate one or more stimulation programs, and a user can synchronously set the timing information of the plurality of stimulation programs by setting the timing information of the target program control mode, so that the requirements of different patients in practical application are met.

In one embodiment, the target programming mode indicates stimulation program a, which indicates: pulse width 60 mus, amplitude 0.2V, frequency 80Hz, timing information of the target programming mode is for example: 12: 00 to 15: 00, it can thus be determined that the timing information of stimulation program a is 12: 00 to 15: 00, then at 12: 00 to 15: 00, applying the electrical stimulation corresponding to the stimulation program a to the patient.

In another specific application, when the target programming mode indicates a plurality of stimulation programs, the timing information of each stimulation program is determined by means of average distribution or preset proportion distribution of the timing information of the target programming mode.

For example: the target program control mode sequentially indicates a stimulation program b, a stimulation program c and a stimulation program d. The timing information of the target program control mode is 15: 00 to 16: 00, the timing information of the stimulation program b is 15: 00 to 15: 20, timing information of the stimulation program c is 15: 20 to 15: 40; timing information for stimulation program d was 15: 40 to 16: 00.

in some optional embodiments, the step S202 may include:

Therefore, when the target program control mode indicates a single stimulation program, the form of the provided electric stimulation is single in the time period corresponding to the timing information of the target program control mode; when the target programming mode indicates a plurality of stimulation programs, electrical stimulation performed in sequence using the plurality of stimulation programs may be provided within a time period corresponding to the timing information of the target programming mode.

In one specific application, the target programming mode sequentially instructs the stimulation program e, the stimulation program f, and the stimulation program g. The duration of the stimulation program e is 120s, the duration of the stimulation program f is 90s, the duration of the stimulation program g is 150s, and the stimulation period of the target program control mode is 120s +90s +150 s-360 s.

The timing information of the target program control mode is 15: 00 to 16: 00, then at 15: 00 to 16: 00, electrical stimulation may be applied to the patient for 10 stimulation cycles in cycles, with timing information for stimulation program e being 0 to 120s, timing information for stimulation program f being 120 to 210s, and timing information for stimulation program g being 210 to 360s, per stimulation cycle (0 to 360 s).

In a specific application, no stimulation (i.e. zero parameter value of the stimulation parameter) may also be used as a stimulation means, e.g. in the form of a stimulation program gap.

For example: the target program control mode sequentially indicates a stimulation program h, a stimulation program j and a stimulation program empty in sequence.

Referring to fig. 3, in some alternative embodiments, the method may further include steps S301 to S302.

Step S301: when a first time period corresponding to the timing information of the target program control mode is overlapped with a second time period corresponding to the preset timing information of the existing program control mode, determining an overlapping time period;

step S302: and when the coincidence time period is detected to be part of the second time period, removing the coincidence time period from the second time period to obtain a remaining time period, and updating the timing information of the existing program control mode by using the remaining time period.

Therefore, when the timing information of the target program control mode conflicts with the previously set timing information of the existing program control mode, the second time period corresponding to the timing information of the existing program control mode is deduplicated with the timing information of the target program control mode as the standard, the timing information of the existing program control mode is updated, the timing information of the target program control mode is not changed (the setting result of the user is maintained), the adjustment intention of the user can be reflected, and the use preference of the user is met.

In a specific application, the first time period corresponding to the timing information of the target program control mode is 2: 00 to 5: 00, a second time period corresponding to the timing information of the existing program control mode is 4: 00 to 7: 00, overlap period 4: 00 to 5: 00, the overlapping time period is a part of the second time period, and after the overlapping time period is removed in the second time period, a remaining time period 5 is obtained: 00 to 7: 00, updating the timing information of the existing program control mode by using the remaining time period, so that the timing information of the existing program control mode indicates 5: 00 to 7: 00.

referring to fig. 4, in some optional embodiments, the method may further include step S303.

Step S303: and when the coincidence time period is detected to be the whole second time period, removing the timing information of the existing program control mode.

Therefore, when the coincidence time period is all the second time period, the timing information of the existing program control mode can be removed, and the program control mode corresponding to the second time period is changed from the existing program control mode to the target program control mode.

In a specific application, the first time period corresponding to the timing information of the target program control mode is 2: 00 to 5: 00, a second time period corresponding to the timing information of the existing program control mode is 4: 00 to 5: 00, overlap period 4: 00 to 5: 00, the coincidence time period is the whole second time period, and the timing information of the existing program control mode is removed.

In some embodiments, when it is detected that the overlap period is the entirety of the second period, the timing information of the existing programming mode may be adjusted (in the form of a delay or the like) so that the first period does not overlap the adjusted second period. In this case, the timing duration of the existing programming mode is unchanged.

In a specific application, the first time period corresponding to the timing information of the target program control mode is 2: 00 to 5: 00, a second time period corresponding to the timing information of the existing program control mode is 4: 00 to 5: 00, overlap period 4: 00 to 5: 00, if the coincidence time period is the whole second time period, adjusting the timing information of the existing program control mode, and after adjustment, the second time period is 5: 00 to 7: 00.

in some optional embodiments, the method may further comprise:

Therefore, by arranging the dial plate and the sliding block, the starting time and the ending time can be clearly and intuitively reflected through the position of the sliding block on the dial plate, and a user can conveniently set timing information.

The shape of the slider is not limited in the present application, and the shape of the slider may be any one of a circle, a triangle, a rectangle, and a polygon.

Referring to fig. 5, in a particular application, the time span represented by a week on the dial may be 6 hours, 8 hours, 12 hours, or 24 hours.

The circumference of the dial may be provided with a plurality of scales, for example: along the clockwise direction of dial plate can be provided with 4 scales, and the moment that these 4 scales represent is 0 in proper order: 00 (24: 00), 6: 00. 12: 00 and 18: 00.

in some embodiments, the dial plate is sequentially provided with N scales along the clockwise direction, and a difference between a time corresponding to the kth scale and a time corresponding to the (k-1) th scale is different from a difference between a time corresponding to the (k + 1) th scale and a time corresponding to the kth scale. N is an integer greater than 2, and k is an integer greater than 1 and less than N.

For example: the dial is provided with 6 scales in turn along the clockwise direction, and the moments represented by the 6 scales are 0: 00. 8: 00. 14: 00. 19: 00. 21: 00 and 23: 00.

in some embodiments, the two sliders may include a start slider for indicating a start time and an end slider for indicating an end time, wherein the set range of the start time and the end time is 0: 00 to 23: 59 (or 0: 00: 00 to 23: 59: 59), and the sliders corresponding to the start slider and the end slider are constant and do not change due to the sliding operation by the user.

In a particular application, the start slider and the end slider may be displayed in the same color and/or the same shape.

In another specific application, the start slider and the end slider may be displayed in different colors and/or different shapes, respectively.

For example, the start slider is displayed as a slider a in blue on the touch screen, the end slider is displayed as a slider b in yellow on the touch screen, and the time corresponding to the position of the slider a is 8: 00, the time corresponding to the sliding block b is 22: 00, the starting time is 8: 00, the end time is 22: 00.

for example, an arc area (having a certain width in the radial direction) corresponding to the timing information of the target program control mode may be displayed in green, and one end of the arc area may point from the starting point to the end point by using a position corresponding to the starting time of the target program control mode as the starting point and another end of the arc area may point from the starting point to the end point by using a position corresponding to the ending time of the target program control mode as the end point, thereby intuitively displaying the time period corresponding to the timing information of the target program control mode.

In some embodiments, when the setting of the timing information of one program control mode is completed, the timing information of the program control mode is the preset timing information of the existing program control mode.

For example, an arc area (having a certain width in the radial direction) corresponding to the timing information of the existing program control mode may be displayed in red, one end of the arc area uses a position corresponding to the start time of the existing program control mode as a starting point, and the other end of the arc area uses a position corresponding to the end time of the existing program control mode as an end point, and points to the end point from the starting point, so as to visually display a time period corresponding to the timing information of the existing program control mode and prompt a user that the time period corresponding to the arc area has the corresponding existing program control mode.

Referring to fig. 6, in some alternative embodiments, the step S201 may include steps S401 to S402.

Step S401: respectively detecting whether the operation of sliding each sliding block is effective or not so as to obtain effective operation in the sliding operation;

step S402: and acquiring timing information of the target program control mode based on the effective operation.

Therefore, the sliding operation can be an operation of sliding one sliding block or an operation of sliding two sliding blocks, and when a user slides one sliding block and the operation of sliding the sliding block is judged to be effective, the timing information of the target program control mode is acquired according to the position of the sliding block; when the user slides the two sliders, as long as the operation of sliding one of the sliders or the two sliders is judged to be effective, the timing information of the target program control mode is acquired according to the position of the slider corresponding to the effective operation.

In some optional embodiments, the step S201 may include:

Thus, when a user slides a slider and the operation of sliding the slider is judged to be effective, the timing information of the target program control mode is acquired according to the position of the slider; when the user slides the two sliders, only the operation of sliding the two sliders is judged to be effective, and the timing information of the target program control mode is acquired according to the positions of the two sliders.

That is, regardless of whether one slider is slid or two sliders are slid, the timing information of the target program control mode is acquired only when the operations corresponding to all the slid sliders are valid, and when the user slides two sliders and only one of the slid operations is determined to be valid, the timing information cannot be set. To patients such as depression, bipolar disorder, the action of making impulsion, anhelation easily, the programme-controlled equipment of this application has certain operation threshold in timing information's setting, only the user can set up timing information in the stable operation under the state of intelligence improvement, cool and quiet to guarantee user's life safety, simultaneously, to personnel of using programme-controlled equipment unintentionally such as children, only by when the operation that gliding all sliders correspond is all effective, just acquire the timing information of target programme-controlled mode, can further avoid the maloperation.

The application can set timing information through simple sliding operation, and the efficiency of setting is promoted for the doctor who uses program control equipment, and simultaneously, the patient who uses this program control equipment has still been considered, judges earlier whether the operation is effective, sets up timing information in view of the above again, has accomplished the people-oriented from this, has embodied humanized care.

Referring to fig. 7, in some alternative embodiments, with one of the sliders being slid as the target slider, the process of detecting whether the operation of sliding the target slider is valid may include steps S501 to S503.

Step S501: acquiring a sliding path corresponding to the target slider based on the operation of sliding the target slider, and detecting whether the positions of all track points of the sliding path are in a preset sliding area;

step S502: when the position of at least one track point of the sliding path is not in the preset sliding area, determining that the operation of sliding the target sliding block is invalid;

step S503: and when the positions of all track points of the sliding path are in the preset sliding area, determining that the operation of sliding the target sliding block is effective.

Therefore, whether the operation of the sliding target slider is effective or not is judged by detecting the positions of the track points of the sliding path, and the operation of the sliding target slider is determined to be effective only when the positions of the track points are in the preset sliding area, so that the timing information is acquired, and therefore the misoperation of a user can be avoided.

Referring to fig. 8, in some alternative embodiments, the process of detecting whether the operation of sliding the target slider is valid may include steps S601 to S604.

Step S601: when the positions of all track points of the sliding path are in the preset sliding area, acquiring a reference path corresponding to the sliding path based on a starting point, an end point and a path direction of the sliding path, wherein the reference path is a part of a preset circular path, the path direction of the reference path is determined by the path direction of the sliding path, and the preset circular path is in the preset sliding area;

step S602: detecting whether the similarity of the sliding path and the reference path is not smaller than a preset similarity threshold value;

step S603: when the similarity is smaller than the preset similarity threshold, determining that the operation of sliding the target slider is invalid;

step S604: and when the similarity is not smaller than the preset similarity threshold, determining that the operation of sliding the target slider is effective.

In some embodiments, the shape of the predetermined sliding area may be a circular ring concentric with the predetermined circumferential path.

Therefore, whether the sliding operation is effective or not is judged by using the detection process in the two stages, the timing information of the target program control mode is acquired only when the sliding operation is judged to be effective, when the positions of all track points of the sliding path are detected in the first stage and are all in the preset sliding area, the sliding operation is not directly determined to be effective, but the detection in the second stage is entered, when the similarity is detected to be not less than the preset similarity threshold value, the sliding operation is determined to be effective, the timing information is acquired, the detection process in the two stages can play a role in double insurance, unreasonable timing information caused by misoperation of a user is avoided, and the life safety of the patient is guaranteed.

In some embodiments, the similarity between the sliding path and the reference path may be obtained as follows:

obtaining a plurality of similarity training data, wherein each similarity training data comprises a sample sliding path used for training, a sample reference path and the labeling similarity of the sample sliding path and the sample reference path;

training a preset deep learning model by using a plurality of similarity training data to obtain a similarity model;

and inputting the sliding path and the reference path into the similarity model to obtain the similarity.

Therefore, a preset deep learning model can be trained according to the similarity training data to obtain a similarity model, corresponding similarities can be automatically generated in real time only by inputting the sliding path and the reference path into the similarity model, and the intelligent degree is high. Through design, a proper amount of neuron calculation nodes and a multilayer operation hierarchical structure are established, a proper input layer and a proper output layer are selected, a preset deep learning model can be obtained, through learning and tuning of the preset deep learning model, a functional relation from input to output is established, although the functional relation between input and output cannot be found 100%, the functional relation can be close to a real incidence relation as far as possible, and the similarity model obtained through training can output corresponding similarity in real time and has high reliability of an output result.

In some embodiments, the preset similarity threshold may be obtained as follows:

acquiring a third corresponding relation between the disease type and the similarity threshold;

and acquiring a similarity threshold corresponding to the disease type of the patient as the preset similarity threshold based on the disease type of the patient and the third corresponding relation.

Therefore, the hand control capability of patients with different disease types is possibly different, compared with the patients with strong hand control force, the deviation between the sliding path and the preset circumferential path of the Parkinson patient with poor hand control force during sliding is possibly larger, the similarity is possibly lower, different preset similarity threshold values are adopted for the patients with different disease types, the program control equipment can support the patient with poor hand control force to perform sliding operation, and the operation difficulty of the patient when the program control equipment is used is greatly reduced.

In a specific application, the threshold of similarity for parkinson's disease is 60%, the threshold of similarity for depression is 80%, and the threshold of similarity for drug addiction is 85%.

For example, if Zhang III is a Parkinson patient, the preset similarity threshold of Zhang III is 60%. When the disease type of the patient is more than one, the lowest one of the similarity thresholds corresponding to all the disease types of the patient can be used as the preset similarity threshold of the patient, or the highest one of the similarity thresholds corresponding to all the disease types of the patient can be used as the preset similarity threshold of the patient.

Referring to fig. 9, in some alternative embodiments, the reference path may be obtained by steps S701 to S703:

step S701: finding a point which is closest to the starting point of the sliding path on the preset circular path to serve as the starting point of the reference path;

step S702: finding a point which is closest to the end point of the sliding path on the preset circular path to serve as the end point of the reference path;

step S703: taking a path between a starting point and an end point of the reference path from the preset circular path as the reference path based on the path direction of the sliding path.

Therefore, a point on the preset circular path, which is closest to the starting point of the sliding path, is used as the starting point of the reference path, a point on the preset circular path, which is closest to the end point of the sliding path, is used as the end point of the reference path, and a path between the starting point and the end point of the reference path along the path direction of the sliding path in the preset circular path is intercepted and used as the reference path, so that the obtained reference path is more attached to the sliding path, the corresponding timing information is more reasonable to obtain according to the reference path, and the intention of a user in setting the timing information can be truly reflected.

Therefore, the clockwise direction of the dial is selected as the extending direction from the starting time to the ending time, and the time period from the starting time to the ending time does not exceed the time period corresponding to half of the dial.

For example: the time period of one circle around the dial is set to be 24 hours (namely, the 24-hour system is adopted), and when the positions of the two sliders correspond to the time of 23: 00 and 1: 00, determine 23: the slider corresponding to 00 is a starting slider, 1: the slider corresponding to 00 is the end slider, and the time period determined thereby is 23: 00 to 1 of the following day: 00(2 hours duration), rather than 1: 00 to 23 of the day: 00 (time duration is 22 hours), which is more suitable for the operation habit of the user.

In a specific application, the time corresponding to the positions of the two sliders is 5: 00 and 15: 00, determination 5: the slider corresponding to 00 is a start slider, 15: the slider corresponding to 00 is the end slider, and the time period determined thereby is 5: 00 to 15: 00 (duration 10 hours).

In this way, the sliders corresponding to the start slider and the end slider are not constant, and the specific allocation of the two sliders is determined by the sliding operation of the user.

For example, the two sliders are a slider c and a slider d, respectively, and when the position of the slider c corresponds to the time 23: 00, the time corresponding to the position of the slide block d is 1: when 00, the slide block c is a starting slide block, and the slide block d is an ending slide block; and when the position of the slide c corresponds to the time 15: 00, the time corresponding to the position of the slide block d is 5: at 00, the slider c is the end slider and the slider d is the start slider.

Referring to fig. 10, in some alternative embodiments, the method may further include steps S801 to S802.

Step S801: displaying clock information of the stimulator and clock information of the programmable device by using the touch screen;

step S802: and receiving synchronous operation by using the touch screen, and responding to the synchronous operation to synchronously process the clock information of the stimulator and the clock information of the program control equipment.

Therefore, the clock information of the stimulator and the clock information of the program control equipment are synchronously processed, so that the condition that the timing information setting of the stimulator and the program control equipment is deviated due to the asynchronous clock information can be avoided.

In one particular application, the clock information of the stimulator indicates 16: 47: clock information indication of the programming device 16: 40: and 20, synchronizing the clock information of the stimulator and the clock information of the programmable device, so that the clock information of the stimulator and the clock information of the programmable device are synchronized, and the synchronization is 16: 40: 20.

in some optional embodiments, the method may further comprise:

Therefore, the time length allowed by the patients with different disease types to receive stimulation is different, and the corresponding preset time length is determined according to the disease types of the patients, so that the timing information can only be set within the range allowed by the corresponding preset time length, and the life safety of the patients is guaranteed.

In a specific application, the preset time period corresponding to the Parkinson's disease is 8 hours, the preset time period corresponding to the depression is 3 hours, and the preset time period corresponding to the drug addiction disease is 7 hours.

For example, if the patient Zhang III is a Parkinson patient, the preset time period of Zhang III is 8 hours. When the disease type of the patient is more than one, the shortest one of the preset time lengths corresponding to all the disease types of the patient can be used as the preset time length of the patient.

In some optional embodiments, the method may further comprise:

The predetermined tissue may be brain tissue, and the predetermined tissue may include one or more of a subthalamic nucleus, a medial globus pallidus, a thalamic ventral intermediate nucleus, a left inner capsular limb, a left nucleus accumbens, a right nucleus accumbens, and a right nucleus accumbens. In some embodiments, the predetermined tissue may be brain tissue formed from a plurality of brain cells. In other embodiments, the predetermined tissue may be a single brain cell.

Therefore, the body tissues stimulated by patients with different disease types are different, and the corresponding target tissues are determined according to the disease types of the patients, so that the electric stimulation is applied to the target tissues of the patients in a targeted manner, and the requirements of practical application are met.

The programmable device of the present application is not limited to the types of diseases that can be used, including but not limited to: convulsive disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., Major Depressive Disorder (MDD)), manic depression, anxiety, post-traumatic stress disorder, depression, Obsessive Compulsive Disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., tremor or parkinson's disease), huntington's disease, alzheimer's disease, drug addiction, or other neurological or psychiatric diseases and injuries. When the program control device is used for treating drug addiction patients, the program control device can help drug addicts to abstain drugs and improve the happiness and life quality of the drug addicts.

Therefore, the stimulator in the patient with different disease types can be controlled by the program control equipment, and the application range is wide.

Referring to fig. 11, the present application further provides a program control device 100, and a specific implementation manner of the program control device is consistent with the implementation manner and the achieved technical effect described in the embodiment of the control method, and details of the implementation manner and the achieved technical effect are not repeated.

The programming device 100 is applied to an implantable neurostimulation system, which comprises the programming device 100 arranged outside a patient body and a stimulator implanted in the patient body;

the programming device 100 is communicatively coupled with the stimulator, the programming device 100 including a controller 103;

the controller 103 is configured to:

receiving a sliding operation by using the touch screen 101, and acquiring timing information of a stimulation program in response to the sliding operation, wherein the stimulation program is used for indicating an identification and a parameter value of a stimulation parameter of the stimulator, and the timing information is used for indicating a starting time and an ending time;

In some embodiments, the controller 103 may include at least one memory, at least one processor, and a bus connecting different platform systems. The memory may include one or more of Random Access Memory (RAM), Read Only Memory (ROM), and cache memory, among others. The memory stores a computer program that can be executed by the processor. The bus may be any of several types of bus structures including a memory bus, a peripheral bus, an accelerated graphics port, or a local bus using any of a variety of bus architectures.

In some optional embodiments, the controller 103 is configured to obtain timing information of the stimulation program as follows:

receiving the sliding operation by using the touch screen 101, and acquiring timing information of a target program control mode in response to the sliding operation, wherein the target program control mode is used for indicating at least one stimulation program;

In some optional embodiments, the controller 103 is further configured to obtain timing information for each of the stimulation programs as follows:

In some optional embodiments, the controller 103 is further configured to:

displaying a dial by using the touch screen 101, and displaying two sliding blocks which can slide in the circumferential direction of the dial, wherein the positions of the two sliding blocks are respectively used for indicating the starting time and the ending time corresponding to the target program control mode;

In some optional embodiments, the controller 103 is further configured to obtain timing information of the target programming mode by:

In some optional embodiments, the controller 103 is further configured to detect whether the operation of sliding the target slider is valid in the following manner:

In some optional embodiments, the controller 103 is further configured to obtain the reference path by:

In some optional embodiments, the controller 103 is further configured to:

displaying clock information of the stimulator and clock information of the programming device 100 by using the touch screen 101;

receiving a synchronization operation by the touch screen 101, and synchronizing the clock information of the stimulator and the clock information of the programming device 100 in response to the synchronization operation.

In some optional embodiments, the controller 103 is further configured to:

In some optional embodiments, the programming device 100 further comprises the touch screen 101 and a communication module 102, and the controller 103 is electrically connected to the touch screen 101 and the communication module 102 respectively;

the touch screen 101 is configured to receive user operations and the communication module 102 is configured to enable data interaction between the programming device 100 and the stimulator.

Referring to fig. 12, the present application further provides an implantable neurostimulation system 300, and the specific implementation manner thereof is consistent with the implementation manner and the achieved technical effect described in the above embodiment of the control method, and details are not repeated.

In some alternative embodiments, the implantable neurostimulation system 300 comprises the programming device 100 disposed outside of a patient and a stimulator 200 implanted within the patient;

the stimulator 200 is configured to generate and apply electrical stimulation to the target tissue of the patient;

the programming device 100 is communicatively coupled with the stimulator 200, the programming device 100 including a controller 103:

the controller 103 is configured to:

receiving a sliding operation by using the touch screen 101, and acquiring timing information of a stimulation program in response to the sliding operation, wherein the stimulation program is used for indicating an identification and a parameter value of a stimulation parameter of the stimulator 200, and the timing information is used for indicating a starting time and an ending time;

based on the stimulation program and its timing information, control instructions are generated and sent to the stimulator 200.

Therefore, the implantable neurostimulation system 300 can meet different stimulation requirements of different patients, and has wide application range and better user experience; and the user can set the timing information through sliding operation, and compared with a mode of gradually adjusting through key operation and a mode of directly inputting a specific numerical value, the operation steps of the user are greatly reduced, so that the setting of the timing information is faster and more convenient, and the use experience of the user is further improved.

It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

When an element is referred to as being "on" or "on," "connected to" or "coupled to" another element, it can be directly on, connected or coupled to the other element or intervening elements may be present. However, when an element is referred to as being "directly on," "directly connected to" or "directly coupled to" another element, there are no intervening elements present. For purposes of this disclosure, the term "connected" may refer to physically, electrically, etc., and may or may not have intermediate components. While the present application is described in terms of various aspects, including exemplary embodiments, the principles of the invention should not be limited to the disclosed embodiments, but are also intended to cover various modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Claims

1. A programming device for use in an implantable neurostimulation system, the implantable neurostimulation system comprising the programming device disposed outside a patient and a stimulator implanted in the patient;

the controller is configured to:

2. The programming device of claim 1, wherein the controller is configured to obtain timing information for the stimulation program by:

3. The programming device according to claim 2, wherein the controller is further configured to obtain timing information for each of the stimulation programs by:

4. The programming device of claim 2, wherein the controller is further configured to:

5. The programming device of claim 4, wherein the controller is further configured to:

6. The programming device of claim 2, wherein the controller is further configured to:

7. The programming device of claim 6, wherein the controller is further configured to obtain timing information for the target programming mode by:

8. The programming device of claim 6, wherein the controller is further configured to obtain timing information for the target programming mode by:

9. The program-controlled apparatus according to claim 7 or 8, wherein, with one of the sliders being slid as a target slider, the process of detecting whether the operation of sliding the target slider is effective is as follows:

10. The programming device in accordance with claim 9, wherein the controller is further configured to detect whether an operation of sliding the target slider is valid by:

11. The programming device of claim 10, wherein the controller is further configured to obtain the reference path by:

12. The programmable device of claim 6, wherein the two sliders comprise a start slider for indicating a start time and an end slider for indicating an end time;

13. The programming device of claim 1, wherein the controller is further configured to:

14. The programming device of claim 2, wherein the controller is further configured to:

15. The programming device of claim 1, wherein the controller is further configured to:

16. The programming device according to claim 1, wherein the stimulation parameter is one or more of a pulse width parameter, an amplitude parameter, and a frequency parameter of a voltage.

17. The programming device of claim 1, wherein the patient's disease type comprises one or more of epilepsy, tremor, parkinson's disease, depression, obsessive compulsive disorder, alzheimer's disease, and drug addiction.

18. The programming device according to claim 1, further comprising the touch screen and a communication module, the controller being electrically connected to the touch screen and the communication module, respectively;

19. An implantable neurostimulation system, comprising the programming device disposed outside a patient and a stimulator implanted in the patient;

the controller is configured to: