CN114306721B - Waterproof and breathable foam dressing and preparation method thereof - Google Patents
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Abstract
The invention provides a waterproof and breathable foam dressing and a preparation method thereof, and relates to the technical field of medical dressings. A waterproof and breathable foam dressing comprises the following raw materials in parts by weight: 0.5-2 parts of glycerol, 0.1-0.5 part of carbomer, 5-8 parts of poloxamer, 0.5-1 part of antibiotic, 2-3 parts of surfactant, 15-17 parts of polyethylene glycol, 1-3 parts of toluene diisocyanate, 0.1-0.5 part of polyvinylpyrrolidone, 5-13 parts of auxiliary material and 0.5-1 part of sodium hyaluronate. The preparation method comprises obtaining filtrate; obtaining a first reactant; obtaining a second reactant; obtaining a third reactant; and obtaining a waterproof and breathable finished foam dressing product. The waterproof and breathable foam dressing has the advantages of good breathability, waterproofness and good wound repair effect.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to a waterproof and breathable foam dressing and a preparation method thereof.
Background
The skin, as the largest organ of the human body, plays an important role in the processes of sensing external stimulation, regulating the body temperature, regulating and controlling the water evaporation loss, protecting various tissues and organs in the body from physical and chemical damages, resisting the invasion of pathogenic microorganisms and the like. When the skin is damaged in large areas, many local and even systemic problems are caused, and serious and even life-threatening problems are caused. Therefore, in the case of a large-area defect or difficult healing of the skin, it is very important to cover the surface of the skin with a medical dressing for repair.
The medical dressing is a medical sanitary material for temporarily covering the surfaces of various wounds and wounds, can be used as a temporary substitute for skin, prevents bacterial infection and other external factors from affecting the skin, prevents excessive loss of moisture and protein, and plays roles in protecting the wound surface and promoting healing. The traditional medical dressing mainly comprises natural materials such as cotton, gauze and bandages, is mostly dry, cannot actively provide a warm and moist healing environment for the wound, cannot promote the recovery of the wound, and has limited capability of maintaining cell tissue fluid; and the traditional medical dressing can be integrated with tissues after the wound is healed, so that secondary injury and pain are brought to a patient in the later dressing removing process. Therefore, the traditional medical dressing is difficult to meet the requirements of people, and the novel medical dressing with better performance is gradually valued by people.
However, the existing dressing has the problems of poor air permeability and water impermeability, and after long-time use, the existing dressing can cause skin to be lack of oxygen and whitened, is not beneficial to wound repair, has poor moisture absorption effect and single applicable environment. Therefore, there is an urgent need to develop a wound dressing that has good air permeability, is truly beneficial to wound repair, and can meet the needs of most patients in terms of cost and comfort.
Disclosure of Invention
The invention aims to provide a waterproof and breathable foam dressing which has the advantages of good breathability, waterproofness and good wound repairing effect
The invention also aims to provide a preparation method of the waterproof and breathable foam dressing, so as to prepare the foam dressing which is good in breathability, waterproof and good in wound repairing effect.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In one aspect, the embodiment of the application provides a waterproof and breathable foam dressing, which comprises the following raw materials in parts by weight: 0.5-2 parts of glycerol, 0.1-0.5 part of carbomer, 5-8 parts of poloxamer, 0.5-1 part of antibiotic, 2-3 parts of surfactant, 15-17 parts of polyethylene glycol, 1-3 parts of toluene diisocyanate, 0.1-0.5 part of polyvinylpyrrolidone, 5-13 parts of auxiliary material and 0.5-1 part of sodium hyaluronate.
In another aspect, embodiments of the present application provide a method for preparing a waterproof and breathable foam dressing, including the following steps:
adding deionized water into the auxiliary materials, mixing, crushing, and filtering to obtain filtrate;
mixing polyethylene glycol and glycerol, heating, adding toluene diisocyanate, and stirring to obtain a first reactant;
mixing poloxamer, antibiotics and a surfactant, adding polyvinylpyrrolidone and deionized water, and stirring to obtain a second reactant;
adding the first reactant and carbomer into the second reactant, stirring uniformly, adding sodium hyaluronate and filtrate, placing in a foaming mold, and carrying out heat preservation reaction to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
according to the invention, glycerol and polyethylene glycol are mixed, toluene diisocyanate is added for reaction, the generated first reactant is mixed with the first reactant and filtrate after the reaction of poloxamer, antibiotics, glycerol, polyvinylpyrrolidone and deionized water, the mixture is mixed with the first reactant and the filtrate, so that the harvested third reactant has excellent hydrophilicity, can absorb wound tissue fluid and has the functions of water resistance and seepage resistance, the foam dressing also has excellent biocompatibility and adhesiveness, the prepared foam dressing can be suitable for the healing stages of various wounds, has semi-sealing property, can prevent grown tissues from entering foam pores, can form a closed environment, provides an environment suitable for wound healing, and further can help wound healing. Moreover, the foam dressing also has good air permeability, so that the skin can not be whitened due to oxygen deficiency. In addition, the filtrate adopting the auxiliary materials can effectively prevent wound infection, has the effects of resisting bacteria and diminishing inflammation, and can promote wound repair and accelerate wound healing. Because the sodium hyaluronate is added, the hydrophilic glycosaminoglycan is an important component of extracellular matrix, can moisten wounds, avoids crusting and plays a role in promoting wound healing. The invention adopts antibiotics, can effectively sterilize and promote wound healing. According to the invention, the PU film is selected as the bearing layer, and based on the characteristics of good elasticity and high lightness of the PU film, the PU film can adapt to joint parts, has the advantages of water resistance and air permeability, can ensure that a wound is ventilated but not infected, and is transparent and visible, can be replaced according to the absorption condition of a dressing, and is more convenient.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a graph showing oxygen permeability in experimental example (II) of the present invention;
FIG. 2 is a graph showing the bacteriostatic rate of Escherichia coli and Staphylococcus aureus in the experimental example (III) of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides a waterproof and breathable foam dressing which comprises the following raw materials in parts by weight: 0.5-2 parts of glycerol, 0.1-0.5 part of carbomer, 5-8 parts of poloxamer, 0.5-1 part of antibiotic, 2-3 parts of surfactant, 15-17 parts of polyethylene glycol, 1-3 parts of toluene diisocyanate, 0.1-0.5 part of polyvinylpyrrolidone, 5-13 parts of auxiliary material and 0.5-1 part of sodium hyaluronate. According to the invention, glycerol and polyethylene glycol are mixed, toluene diisocyanate is added for reaction, the generated first reactant is mixed with the first reactant and filtrate after poloxamer, antibiotics, glycerol, polyvinylpyrrolidone and deionized water are mixed and reacted, and then the mixture is mixed with the first reactant and the filtrate, so that the harvested third reactant has excellent hydrophilicity and biocompatibility and adhesiveness, and the prepared foam dressing can be suitable for healing stages of various wounds, has semi-closed property, can prevent grown tissues from entering foam pores, and further can help the wounds to heal. In addition, the filtrate adopting the auxiliary materials can effectively prevent wound infection, has the effects of resisting bacteria and diminishing inflammation, and can promote wound repair and accelerate wound healing. The sodium hyaluronate is added, is hydrophilic glycosaminoglycan, is an important component of extracellular matrix, can moisten wounds, avoids crusting and plays a role in promoting wound healing. The invention adopts antibiotics, can effectively sterilize and promote wound healing.
In some embodiments of the present invention, the above-mentioned auxiliary materials comprise 2 to 5 parts by weight of notoginseng, 1 to 3 parts by weight of phellodendron bark, 1 to 2 parts by weight of dragon's blood and 1 to 3 parts by weight of frankincense. The pseudo-ginseng has the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain, can effectively shorten bleeding and blood coagulation time, can resist platelet aggregation and promote the proliferation of hematopoietic stem cells when being acted on a wound surface, thereby promoting the healing of the wound surface; the phellodendron bark has an inhibiting effect on dermatophytes, and can inhibit the growth of bacteria around a wound surface, so that the wound surface is ensured to heal, and the wound surface is prevented from being infected by bacteria; the dragon's blood has the functions of promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, healing sore and promoting granulation, and can effectively promote blood circulation, heal wound, promote wound healing, relieve wound pain and further promote wound healing when being applied to the wound; the frankincense can effectively play roles in activating blood and qi, relieving pain and promoting granulation, and can diminish inflammation, relieve pain, increase leucocytes and promote wound healing. Under the cooperation of the medicines, the wound surface healing speed can be effectively accelerated, and the effect of promoting wound healing is further achieved.
In some embodiments of the present invention, the surfactant is silicone oil L580.
The present invention also provides a method of manufacturing a waterproof breathable foam dressing comprising the steps of:
adding deionized water into the auxiliary materials, mixing, crushing, and filtering to obtain filtrate;
mixing polyethylene glycol and glycerol, heating, adding toluene diisocyanate, and stirring to obtain a first reactant;
mixing poloxamer, antibiotics and a surfactant, adding polyvinylpyrrolidone and deionized water, and stirring to obtain a second reactant;
adding the first reactant and carbomer into the second reactant, stirring uniformly, adding sodium hyaluronate and filtrate, placing in a foaming mold, and carrying out heat preservation reaction to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing (the finished product is solid).
The foam dressing can be prepared quickly, simply and conveniently by the method. The material of bearer layer is the PU membrane, selects the PU membrane as the bearer layer, and it is good to have elasticity based on the PU membrane, slightly high characteristics, can adapt to joint position, and it has waterproof ventilative advantage simultaneously, can make the ventilative nevertheless not infected of wound, and in addition, the PU membrane is transparent visual, can change according to the absorption condition of dressing, and is more convenient.
In some embodiments of the present invention, the weight ratio of the deionized water to the auxiliary materials is (1-2): 1, the impurity content of the filtered filtrate is lower than 0.1 percent. So that the content of the harvested filtrate is not excessive, the concentration of active ingredients in the filtrate is ensured, and the filtrate is pasteurized to ensure the safety of the final product. The impurity of the filtrate is low, the purity of the finally prepared product can be ensured, and the stable quality of the foam dressing is further ensured, so that the effect is stable.
In some embodiments of the present invention, the first reactant is specifically obtained by mixing polyethylene glycol and glycerol, heating to 60-75 ℃, adding toluene diisocyanate, and stirring for 1-2 hours.
In some embodiments of the present invention, the second reactant is specifically prepared by mixing poloxamer, antibiotic and surfactant, adding polyvinylpyrrolidone, mixing, and adding the mixture to polyvinylpyrrolidone, poloxamer, antibiotic and surfactant in a weight ratio of (1.5-3): 1 for 1-2min to obtain a second reactant.
In some embodiments of the invention, the antibiotic is at least one of gentamicin, aspirin, and erythromycin hydrochloride.
In some embodiments of the present invention, the third reactant is specifically obtained by adding the first reactant and carbomer into the second reactant, stirring uniformly at a speed of 1000 to 3000r/min, adding sodium hyaluronate and filtrate, placing in a foaming mold, and performing a heat preservation reaction at 50 to 70 ℃ to obtain the third reactant, wherein a weight ratio of the first reactant to the second reactant is (1-2): 1.
in some embodiments of the present invention, the third reactant is obtained after heat preservation at 50-70 ℃ for 8-10h in a foaming mold.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 20g of pseudo-ginseng, 10g of golden cypress, 10g of dragon's blood, 10g of frankincense and 50g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content of less than 0.1%;
mixing 150g of polyethylene glycol and 5g of glycerol, heating to 60 ℃, adding 10g of toluene diisocyanate, and stirring for 1 hour to obtain a first reactant;
mixing 50g of poloxamer, 5g of gentamicin and 20g of silicone oil L580, adding 1g of polyvinylpyrrolidone and 114g of deionized water, and stirring for 1min to obtain a second reactant;
mixing the first reactant and the second reactant according to a weight ratio of 1:1, adding 1g of carbomer, stirring uniformly at a speed of 1000-3000 r/min, adding 5g of sodium hyaluronate and filtrate, placing in a foaming mold, and keeping the temperature at 50 ℃ for 8 hours to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
Example 2
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 40g of pseudo-ginseng, 20g of golden cypress, 15g of dragon's blood, 20g of frankincense and 142g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content lower than 0.1%;
mixing 160g of polyethylene glycol and 12g of glycerol, heating to 70 ℃, adding 20g of toluene diisocyanate, and stirring for 1.5 hours to obtain a first reactant;
mixing 70g of poloxamer, 8g of gentamicin and 20g of silicone oil L580, adding 3g of polyvinylpyrrolidone and 200g of deionized water, and stirring for 1.5min to obtain a second reactant;
mixing the first reactant and the second reactant according to a weight ratio of 1.5:1, adding 3g of carbomer, stirring uniformly at a speed of 1000-3000 r/min, adding 8g of sodium hyaluronate and filtrate, placing in a foaming mold, and keeping the temperature at 60 ℃ for 9 hours to obtain a third reactant;
and (3) applying a third reactant on the bearing layer to obtain a finished waterproof and breathable foam dressing product.
Example 3
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 50g of pseudo-ginseng, 30g of golden cypress, 20g of dragon's blood, 30g of frankincense and 260g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content of less than 0.1%;
mixing 170g of polyethylene glycol and 20g of glycerol, heating to 75 ℃, adding 30g of toluene diisocyanate, and stirring for 2 hours to obtain a first reactant;
mixing 80g of poloxamer, 10g of gentamicin and 30g of silicone oil L580, adding 5g of polyvinylpyrrolidone and 375g of deionized water, and stirring for 2min to obtain a second reactant;
mixing a first reactant and a second reactant according to a weight ratio of 2:1, adding 5g of carbomer, uniformly stirring at a speed of 1000-3000 r/min, adding 10g of sodium hyaluronate and filtrate, placing in a foaming mold, and preserving heat at 70 ℃ for 10 hours to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
Example 4
This example differs from example 2 in that: the antibiotic is aspirin.
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 40g of pseudo-ginseng, 20g of golden cypress, 15g of dragon's blood, 20g of frankincense and 142g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content of less than 0.1%;
mixing 160g of polyethylene glycol and 12g of glycerol, heating to 70 ℃, adding 20g of toluene diisocyanate, and stirring for 1.5 hours to obtain a first reactant;
mixing 70g of poloxamer, 8g of aspirin and 20g of silicone oil L580, adding 3g of polyvinylpyrrolidone and 200g of deionized water, and stirring for 1.5min to obtain a second reactant;
mixing the first reactant and the second reactant according to a weight ratio of 1.5:1, adding 3g of carbomer, stirring uniformly at a speed of 1000-3000 r/min, adding 8g of sodium hyaluronate and filtrate, placing in a foaming mold, and keeping the temperature at 60 ℃ for 9 hours to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
Example 5
This example differs from example 2 in that: the antibiotic is erythromycin hydrochloride.
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 40g of pseudo-ginseng, 20g of golden cypress, 15g of dragon's blood, 20g of frankincense and 142g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content lower than 0.1%;
mixing 160g of polyethylene glycol and 12g of glycerol, heating to 70 ℃, adding 20g of toluene diisocyanate, and stirring for 1.5 hours to obtain a first reactant;
70g of poloxamer, 8g of erythromycin hydrochloride and 20g of silicone oil L580 are mixed, 3g of polyvinylpyrrolidone and 200g of deionized water are added, and stirring is carried out for 1.5min to obtain a second reactant;
mixing the first reactant and the second reactant according to a weight ratio of 1.5:1, adding 3g of carbomer, stirring uniformly at a speed of 1000-3000 r/min, adding 8g of sodium hyaluronate and filtrate, placing in a foaming mold, and keeping the temperature at 60 ℃ for 9 hours to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
Example 6
This example differs from example 2 in that: the antibiotics are gentamicin, aspirin and erythromycin hydrochloride.
A method of manufacturing a waterproof breathable foam dressing comprising the steps of:
mixing 40g of pseudo-ginseng, 20g of golden cypress, 15g of dragon's blood, 20g of frankincense and 142g of deionized water, crushing after mixing, and filtering to obtain filtrate with the impurity content of less than 0.1%;
mixing 160g of polyethylene glycol and 12g of glycerol, heating to 70 ℃, adding 20g of toluene diisocyanate, and stirring for 1.5 hours to obtain a first reactant;
70g of poloxamer, 2g of gentamicin, 3g of aspirin, 3g of erythromycin hydrochloride and 20g of silicone oil L580 are mixed, 3g of polyvinylpyrrolidone and 200g of deionized water are added, and stirring is carried out for 1.5min to obtain a second reactant;
mixing the first reactant and the second reactant according to a weight ratio of 1.5:1, adding 3g of carbomer, stirring uniformly at a speed of 1000-3000 r/min, adding 8g of sodium hyaluronate and filtrate, placing in a foaming mold, and keeping the temperature at 60 ℃ for 9 hours to obtain a third reactant;
and (3) applying a third reactant on the bearing layer to obtain a finished waterproof and breathable foam dressing product.
Examples of the experiments
Dressing in vitro cytotoxicity test
The test is carried out according to the test method of GB/T16886.5-2017 medical apparatus biological evaluation part 5 in vitro cytotoxicity test, the foam dressing prepared in the examples 1-6 of the application is tested according to the determination method of cytotoxicity, and discrete particles are detected in cytoplasm, no cell is dissolved, and the condition of no cell proliferation decrease is 0-level no reaction; no more than 20% of the cells were found to be rounded, loosely adherent, free of intracytoplasmic granules or show a change in morphology, or occasionally lysed, and only a slight inhibition of cell growth was observed as a grade 1 mild response; measuring that no more than 50% of cells are in a round shrinkage state and have no intracytoplasmic granules, no large-range cell lysis exists, and no more than 50% of cell growth inhibition condition can be observed as a grade 2 mild reaction degree; no more than 70% of the cells were found to be rounded or lysed, the cell layer was not completely destroyed, but more than 50% of the cell growth inhibition was observed as grade 3 moderate degree of response; almost complete or complete destruction of the cell layer was measured as a degree of grade 4 severe response.
The examination of the foam dressings prepared in examples 1 to 6 of the present application is shown in table 1.
TABLE 1
| Test specimen | Extent of reaction |
| Example 1 | |
| Example 2 | |
| Example 3 | Level 1 |
| Example 4 | |
| Example 5 | |
| Example 6 | |
As can be seen from table 1, the cytotoxicity of the foam dressing prepared in the present application was 0 to 1 grade, which indicates that the foam dressing prepared in the present application is safe.
Oxygen permeability
The oxygen permeability of each of the foam dressings prepared in examples 1 to 6 of the present application was examined by a differential pressure gas permeameter, and the results are shown in fig. 1.
According to figure 1, the air permeability of the foam dressing prepared by the method is good, and the maximum air permeability can reach 310 multiplied by 10− 11cm3·cm/cm2S mmHg, because the foam dressing prepared in this application is porous, it has excellent oxygen permeability.
(III) bacteriostatic property
In the application, escherichia coli and staphylococcus aureus are used as gram-negative bacteria and gram-positive bacteria models, the antibacterial performance of the foam dressing prepared in the examples 1-6 is detected by adopting an agar diffusion method, and the inhibition effect of the foam dressing on the bacterial growth is detected.
Culturing Escherichia coli and Staphylococcus aureus in LB culture solution for 24h, measuring absorbance of bacteria solution at wavelength of 600nm with ultraviolet-visible spectrophotometer, and diluting to 10 with LB culture solution5And (3) each CFU/mL is reserved, 100 mu L of bacterial solution is respectively dripped on the foam dressing prepared in the embodiment 1-6, a blank group (without the foam dressing) is used as a control group, 100 mu L of bacterial solution is dripped on the blank group, shaking culture is carried out for 24h, then absorbance is detected, and the bacteriostasis rate is tested. The bacteriostasis rate is obtained by dividing the difference between the absorbance of the control group and the absorbance of the example group by the difference between the absorbance of the control group and the absorbance of the LB medium and then multiplying the obtained product by one hundred percent. The results are shown in FIG. 2. FIG. 2 shows the bacteriostatic rates of E.coli and S.aureus.
According to fig. 2, it can be seen that the foam dressings prepared in examples 1 to 6 of the present application have good inhibitory effects on bacteria, and the inhibitory rate is greater than 99% for both escherichia coli and staphylococcus aureus.
In summary, according to the present invention, glycerol and polyethylene glycol are mixed, toluene diisocyanate is added to react, so as to generate the first reactant, poloxamer, antibiotic, glycerol, polyvinylpyrrolidone and deionized water are mixed to react, and then the first reactant and the filtrate are mixed, so that the harvested third reactant has excellent hydrophilicity, can absorb wound tissue fluid, has waterproof and anti-permeation effects, and also has excellent biocompatibility and adhesiveness, and the prepared foam dressing can be applied to various wound healing stages, has semi-sealing properties, can prevent grown tissue from entering foam pores, can form a closed environment, provides an environment suitable for wound healing, and further can help wound healing. Moreover, the foam dressing also has good air permeability, so that the skin can not be whitened due to oxygen deficiency. In addition, the filtrate adopting the auxiliary materials can effectively prevent wound infection, has the effects of resisting bacteria and diminishing inflammation, and can promote wound repair and accelerate wound healing. Because the sodium hyaluronate is added, the hydrophilic glycosaminoglycan is an important component of extracellular matrix, can moisten wounds, avoids crusting and plays a role in promoting wound healing. The invention adopts antibiotics, can effectively sterilize and promote wound healing. According to the invention, the third reactant is coated on the bearing layer, and the bearing layer has a good waterproof effect, so that the foam dressing prepared by the method also has a good waterproof effect.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The waterproof and breathable foam dressing is characterized by comprising the following raw materials in parts by weight: 0.5-2 parts of glycerol, 0.1-0.5 part of carbomer, 5-8 parts of poloxamer, 0.5-1 part of antibiotic, 2-3 parts of surfactant, 15-17 parts of polyethylene glycol, 1-3 parts of toluene diisocyanate, 0.1-0.5 part of polyvinylpyrrolidone, 5-13 parts of auxiliary material and 0.5-1 part of sodium hyaluronate.
2. The waterproof and breathable foam dressing as claimed in claim 1, wherein the auxiliary materials comprise 2-5 parts by weight of pseudo-ginseng, 1-3 parts by weight of phellodendron amurense, 1-2 parts by weight of dragon's blood and 1-3 parts by weight of frankincense.
3. The waterproof breathable foam dressing of claim 1, wherein the surfactant is silicone oil L580.
4. A method of manufacturing a waterproof breathable foam dressing according to any one of claims 1 to 3, characterized in that it comprises the following steps:
adding deionized water into the auxiliary materials, mixing, crushing, and filtering to obtain filtrate;
mixing polyethylene glycol and glycerol, heating, adding toluene diisocyanate, and stirring to obtain a first reactant;
mixing poloxamer, antibiotics and a surfactant, adding polyvinylpyrrolidone and deionized water, and stirring to obtain a second reactant;
adding the first reactant and carbomer into the second reactant, stirring uniformly, adding sodium hyaluronate and filtrate, placing in a foaming mold, and carrying out heat preservation reaction to obtain a third reactant;
and (3) coating the third reactant on the bearing layer to obtain the finished waterproof and breathable foam dressing.
5. The method for preparing the waterproof and breathable foam dressing according to claim 4, wherein the weight ratio of the deionized water to the auxiliary materials is (1-2): 1, and the impurity content of the filtered filtrate is lower than 0.1%.
6. The preparation method of the waterproof and breathable foam dressing according to claim 4, wherein the first reactant is obtained by mixing polyethylene glycol and glycerol, heating to 60-75 ℃, adding toluene diisocyanate, and stirring for 1-2 hours.
7. The preparation method of the waterproof and breathable foam dressing according to claim 4, wherein the second reactant is prepared by mixing poloxamer, antibiotic and surfactant, adding polyvinylpyrrolidone, mixing, and adding the mixture, wherein the weight ratio of the mixture to the polyvinylpyrrolidone, the poloxamer, the antibiotic and the surfactant is (1.5-3): 1 for 1-2min to obtain a second reactant.
8. The method for preparing the waterproof and breathable foam dressing according to claim 4, wherein the antibiotic is at least one of gentamicin, aspirin and erythromycin hydrochloride.
9. The preparation method of the waterproof and breathable foam dressing according to claim 4, wherein the third reactant is obtained by adding the first reactant and carbomer into the second reactant, uniformly stirring at a speed of 1000-3000 r/min, adding sodium hyaluronate and filtrate, placing in a foaming mold, and carrying out heat preservation reaction at 50-70 ℃ to obtain the third reactant, wherein the weight ratio of the first reactant to the second reactant is (1-2): 1.
10. the method for preparing the waterproof and breathable foam dressing according to claim 4, wherein the third reactant is obtained after heat preservation at 50-70 ℃ for 8-10 hours in a foaming mold.
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| CN109432481A (en) * | 2018-12-06 | 2019-03-08 | 广州润虹医药科技股份有限公司 | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof |
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| CN113041389A (en) * | 2021-05-06 | 2021-06-29 | 南昌智产科技有限公司 | Medical dressing of antibiotic hydrophilic polyurethane foam |
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