CN114306559A - Formula for treating gouty arthritis through oral administration and external washing - Google Patents

Abstract

The invention discloses a formula for treating gouty arthritis by oral administration and external washing, which is prepared from the following raw materials in parts by weight: 15g of Chinese pulsatilla root, 30g of rabdosia rubescens, 15g of siegesbeckia orientalis, 15g of yam, 30g of glabrous greenbrier rhizome, 30g of kudzuvine root, 30g of sargentgloryvine stem, 15g of Chinese angelica, 20g of prepared rehmannia root, 30g of Chinese yam, 15g of radix achyranthis bidentatae, 15g of plantain seed, 15g of largehead atractylodes rhizome, 30g of astragalus, 12g of turmeric, 12g of cassia twig and 6g of scorpion. The traditional Chinese medicine composition is prepared according to the traditional Chinese medicine theory and the guidance thought of detoxifying, purging turbidity and removing blood stasis, achieves the purposes of improving joint function, relieving pain, promoting uric acid excretion, reducing hyperuricemia and improving life quality by tonifying five internal organs, enhancing the immunity of the organism, clearing heat, detoxifying, promoting diuresis, removing blood stasis, eliminating phlegm, dispelling rheumatism, benefiting joints, dredging collaterals and relieving pain, and obtains better curative effect clinically; the traditional Chinese medicine composition accords with the theory of traditional Chinese medicine and aims at the pathogenesis characteristics of gouty arthritis, and has the advantages of definite curative effect, high safety, small toxic and side effects, little possibility of damage to the metabolism of liver and kidney.

Description

Formula for treating gouty arthritis through oral administration and external washing

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a formula for treating gouty arthritis by oral administration and external washing.

Background

Gout (gout) is a heterogeneous disease formed by abnormal increase of blood uric acid level of a human body due to purine metabolic disorder and uric acid excretion disorder and deposition of urate crystals among tissues, and the clinical characteristics of hyperuricemia, tophus deposition, repeated attack of characteristic acute and chronic arthritis and even renal failure seriously affect the life quality of patients.

The traditional Chinese medicine considers that the innate endowment is insufficient, and the acquired preference to eating the thick taste of the ointment beam gradually damages the spleen, so that the dampness and turbidity are not dissolved for a long time until the dampness and turbidity are accumulated and the joints are unfavorable; or the dysfunction of spleen and kidney after aging is the main cause of gouty arthritis, and has a certain relationship with the causes of fatigue, diet, environment, exopathic infection and the like.

Modern medicine has the following medicines for treating acute gouty arthritis: non-steroidal anti-inflammatory drugs, colchicine, glucocorticoids, biological agents and the like. The 2012 ACR guidelines recommend that monotherapy or combination therapy be applied depending on the severity of the arthritis and the number of affected joints. When the non-steroidal anti-inflammatory drug is applied, adverse reactions such as thrombotic cardiovascular events, gastrointestinal perforation, ulcer, bleeding and the like are easily induced.

Disclosure of Invention

The invention aims to provide a formula for treating gouty arthritis by oral administration and external washing, which considers that the main pathogenesis of gout is dampness turbidity, stasis and internal resistance, is prepared by the guidance idea of detoxifying, purging turbidity and removing stasis, achieves the aims of improving joint function, relieving pain and improving life quality by tonifying five internal organs, enhancing the immunity of the organism, clearing away heat and toxic materials, promoting diuresis, removing turbidity, removing stasis and eliminating phlegm, dispelling wind-damp and benefiting joints, and dredging collaterals and relieving pain, and obtains better curative effect clinically.

In order to solve the technical problems, the invention adopts the following technical scheme:

the invention provides a formula for treating gouty arthritis by oral administration and external washing, which is characterized by being prepared from the following raw materials in parts by weight: 15g of Chinese pulsatilla root, 30g of rabdosia rubescens, 15g of siegesbeckia orientalis, 15g of yam, 30g of glabrous greenbrier rhizome, 30g of kudzuvine root, 30g of sargentgloryvine stem, 15g of Chinese angelica, 20g of prepared rehmannia root, 30g of Chinese yam, 15g of radix achyranthis bidentatae, 15g of plantain seed, 15g of largehead atractylodes rhizome, 30g of astragalus, 12g of turmeric, 12g of cassia twig and 6g of scorpion.

The using method comprises the following steps:

1. decocting with water 1 dose 900ml daily, and orally administering at 3 times, 200ml each time, and 7 days as a treatment course. The curative effect is observed after 2 treatment courses.

2. 300ml is applied to swelling and pain joints for 2 times of wet (hot) application for 30 minutes each time;

3. making into powder, pill or capsule at a certain proportion, 3 times daily, 12g each time; the patch is applied 1 time per day.

The invention has the beneficial effects that:

1. according to the traditional Chinese medicine theory, the traditional Chinese medicine composition is formulated according to the guiding thought of detoxifying, purging turbidity and removing blood stasis, and achieves the purposes of improving joint functions, relieving pain, promoting uric acid excretion, reducing hyperuricemia and improving life quality by tonifying five internal organs, enhancing the immunity of the organism, clearing heat, detoxifying, promoting diuresis, discharging turbidity, removing blood stasis, eliminating phlegm, dispelling wind-damp, benefiting joints, dredging collaterals and relieving pain, so that a better curative effect is obtained clinically.

2. The traditional Chinese medicine composition accords with the theory of traditional Chinese medicine and aims at the pathogenesis characteristics of gouty arthritis, has definite curative effect and high safety, and hardly has damage to the metabolism of liver and kidney.

3. The formula has obvious clinical curative effect on treating acute gouty arthritis, can obviously improve the clinical effect of patients, and has great significance for tracking and treating the illness state of the patients.

The following further explains the beneficial effects of the invention by combining the effects of the main components in the invention:

rabdosia rubescens (nature and taste) is bitter, sweet and slightly cold. [ FUNCTIONS ] has effects in clearing away heat and toxic materials, promoting blood circulation, and relieving pain. Can be used for treating throat pain including acute pharyngitis and tonsillitis, skin snake bite, rheumatic osteoarthropathy, osteodynia, etc

Chinese pulsatilla root (nature and taste) is bitter in taste and cold in nature; gui Wei and Dachang Jing (function indications) have the effects of clearing away heat and toxic material, cooling blood, improving eyesight, eliminating dampness and killing parasites, and are mainly used for treating clinical diseases of heat-toxin dysentery, epistaxis, blood hemorrhoids, leukorrhagia, pruritus vulvae, pyocutaneous disease, scrofula and the like in clinic. In addition, the Chinese medicinal preparation also has obvious treatment effects on stomachache, bloody toxin dysentery, toothache and fracture pain. The water decoction of the Chinese pulsatilla root has obvious inhibition effect on various bacterial infections of a body, such as dysentery bacillus infection and intestinal pathogenic bacteria infection. The Chinese medicinal composition can be used for treating infection symptoms of a human body by being combined with medicaments such as coptis chinensis, ash bark, phellodendron and the like, and has an obvious good treatment effect.

Herba siegesbeckiae: [ PROPERTIES AND WESTERN ] is pungent, bitter and cold in nature; enters liver and kidney meridians and has the efficacies of expelling wind-damp, benefiting joints and detoxifying. It can be used for treating rheumatalgia, apoplexy, hemiplegia, rubella, eczema, skin ulcer, and carbuncle.

1, Ningpo Yam rhizome: [ PROPERTIES AND WESTERN-FRIENDLY ] bitter in taste and slightly cold in nature; enters liver and lung meridians and has the efficacies of dispelling wind-damp, promoting blood circulation to remove meridian obstruction, clearing lung and eliminating phlegm. It can be used for treating rheumatism, cough with asthma due to phlegm-heat, thoracic obstruction, traumatic injury, carbuncle, swelling, and sore.

Glabrous greenbrier rhizome: [ PROPERTIES AND FLAVOUR ] sweet, bland and neutral; they enter liver and stomach meridians and have the actions and indications of removing toxicity, removing dampness and easing joint movement. It can be used for treating syphilis sore, spasm of limbs, stranguria with turbid discharge, leukorrhagia, eczema, pruritus, carbuncle, swelling, and sore.

Kudzu root: [ PROPERTIES AND FLAVOUR ] sweet, pungent and cool in nature; invigorating spleen and stomach meridians [ function and indication ] has the effects of relieving muscles and fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and relieving diarrhea. It can be used for treating fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency.

Sargentgloryvine stem: [ PROPERTIES AND FLAVOUR ] bitter in taste and neutral in nature; belongs to large intestine and liver channel, has the efficacies of clearing away heat and toxic material, promoting blood circulation, dispelling wind and relieving pain. It can be used for treating abdominal pain due to intestinal abscess, heat-toxin pyocutaneous disease, traumatic injury, amenorrhea, dysmenorrhea, and rheumatalgia.

Prepared rehmannia root: [ PROPERTIES AND WESTERN PROPERTIES ] the medicine which belongs to the liver channel and the kidney channel is prepared by steaming and drying the dried rehmannia root, has the functions of nourishing, nourishing yin, enriching the blood, replenishing essence and replenishing marrow, and is used for treating deficiency fire flaring-up phenomena of liver and kidney yin deficiency, soreness and weakness of waist and knees, bone steaming tidal fever, spermatorrhea, night sweat, thirst-quenching internal heat and liver and kidney yin deficiency, and also can treat sallow complexion, palpitation, abnormal menstruation, metrorrhagia, leukorrhagia and other blood deficiency symptoms caused by blood deficiency.

Chinese yam: [ PROPERTIES AND FLAVOUR ] sweet in taste and neutral in nature; enter spleen, lung and kidney meridians and have the efficacies of supplementing qi and nourishing yin, tonifying spleen, lung and kidney, and securing essence and stopping leukorrhagia. It can be used for treating spleen deficiency, anorexia, asthenia, loose stool, diarrhea, cough and asthma due to lung deficiency, spermatorrhea, leukorrhagia, frequent micturition, internal heat, and diabetes.

Achyranthes bidentata: [ CHARACTERISTICS AND WESTER ] is bitter, sweet, sour and neutral, and is used in liver and kidney meridians, and has the functions of promoting blood circulation, dredging channels, nourishing liver and kidney, strengthening bones and muscles, inducing diuresis, treating stranguria, and purging pathogenic fire. Achyranthes root has the functions of promoting blood circulation, removing blood stasis, dredging the meridian and reducing the excretion, so the medicine is more suitable for various gynecological diseases and traumatic injury. It is commonly used to treat amenorrhea, dysmenorrhea, abdominal pain during menstruation, retained afterbirth and traumatic injury caused by blood stasis. The achyranthes root has the functions of invigorating liver and kidney, strengthening tendons and bones and dispelling rheumatism while activating blood circulation, so that the achyranthes root can be used for treating soreness and pain of waist and knees and flaccidity of lower limbs. Niu xi is good at moving downward and can induce diuresis to treat stranguria, so it can be used to treat stranguria, edema and dysuria. Achyranthes root, radix Achyranthis bidentatae is bitter in taste and good at purging and descending, can conduct heat and purge and draw blood downward, and can also treat headache, vertigo, toothache, aphtha of the mouth and tongue, hematemesis and other symptoms.

Plantain seed: [ PROPERTIES AND WESTERN PROPERTIES ] the meridian tropism is sweet and bland in flavor, and slightly cold in nature; it enters lung, liver, kidney and bladder meridians. [ FUNCTIONS INDICATION ] has effects of clearing heat, promoting diuresis, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm. It can be used for treating dysuria, stranguria with turbid discharge, edema, dysentery, conjunctival congestion, nebula, and cough with dyspnea due to phlegm-heat.

White atractylodes rhizome: [ PROPERTIES AND flavors ] is bitter, sweet and warm, enters spleen and stomach meridians, and [ functions and indications ] induce diuresis to alleviate edema, strengthen superficies to arrest sweating, eliminate dampness and strengthen spleen. Atractylodis rhizoma can be used for treating spleen deficiency, abdominal distention, and diarrhea. Bighead atractylodes rhizome can promote diuresis, so that edema can be treated, spontaneous perspiration can also be treated, and the medicine can treat symptoms of dizziness and palpitation caused by phlegm and fluid retention. The rhizoma atractylodis macrocephalae can prevent miscarriage and treat diseases of restlessness and premature delivery of fetuses. Atractylodis rhizoma has effects of invigorating spleen, regulating stomach function, eliminating dampness, promoting diuresis, preventing miscarriage, and suppressing sweating.

Astragalus root: [ PROPERTIES AND DENSITY ] sweet and warm in nature and entering lung and spleen meridians [ functions and indications ] has the main core function of tonifying qi, strengthening exterior and promoting pus discharge, healing sore and tissue regeneration, and inducing diuresis and expelling toxin. In clinic, Huangqi is indicated for qi deficiency and hypodynamia due to qi deficiency, and also for qi deficiency in middle energizer manifested as inability to eat food, abdominal distention, loose stool, etc. In addition, radix astragali has the function of relieving collapse, can treat collapse of middle-jiao energy, such as proctoptosis and chronic dribbling, can also treat edema, ulcer and carbuncle-abscess due to qi deficiency, can tonify qi and heal wound, can treat internal heat, cough and diabetes, and also has the function of treating nephritis and albuminuria inside blood.

Turmeric: [ PROPERTIES AND WESTERN ] is pungent, bitter and cold in nature; the liver, gallbladder and heart meridians (function indications) have the efficacies of activating blood and qi, and dredging channels and relieving pain. It is mainly used for treating pain due to qi stagnation and blood stasis, and arthralgia due to wind-dampness.

Chinese angelica: [ PROPERTIES AND FLAVOUR ] is sweet, pungent and warm. [ FUNCTIONS ] can tonify blood, regulate menstruation, alleviate pain, moisten dryness and smooth intestines. Treating menoxenia, amenorrhea, abdominal pain, abdominal mass, metrorrhagia and metrostaxis; headache due to blood deficiency, vertigo, flaccidity arthralgia; intestinal dryness, difficulty in defecation, and severe dysentery; carbuncle, deep-rooted carbuncle, sore, traumatic injury.

Cassia twig: [ PROPERTIES AND FLAVOUR ] pungent, sweet and warm. Meridian tropism includes heart, lung and bladder meridians. [ FUNCTIONS ] can induce sweat, dispel muscles, warm and dredge meridians, strengthen yang, regulate qi, and calm the adverse flow of qi. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.

Scorpion: [ PROPERTIES AND FLAVOURS ]: salty, pungent, neutral and toxic. Meridian tropism: the meridian of foot jueyin. [ Functions and indications ]: dispelling pathogenic wind, relieving spasm, dredging collaterals, and removing toxic substance; it can be used for treating convulsion, epilepsy, apoplexy, hemiplegia, facial distortion, migraine, rheumatalgia, tetanus, tuberculous lymphadenitis, and rubella and sore. Detailed Description

The technical solutions of the present invention will be described clearly and completely in the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

A formula for treating gouty arthritis through oral administration and external washing is prepared from the following raw materials in parts by weight: 15g of Chinese pulsatilla root, 30g of rabdosia rubescens, 15g of siegesbeckia orientalis, 15g of dioscorea nipponica makino, 30g of glabrous greenbrier rhizome, 30g of kudzuvine root, 30g of sargentgloryvine stem, 15g of Chinese angelica, 20g of prepared rehmannia root, 30g of Chinese yam, 15g of radix achyranthis bidentatae, 15g of plantain seed, 15g of largehead atractylodes rhizome, 30g of astragalus, 12g of turmeric, 12g of cassia twig and 6g of scorpion

The compatibility of the components is characterized in that:

the compatibility efficacy is enhanced: the Chinese pulsatilla root has the effects of clearing heat, eliminating dampness, cooling blood and detoxifying, the rabdosia rubescens has the effects of clearing heat, detoxifying, cooling blood, the glabrous greenbrier rhizome has the effects of detoxifying, dispelling wind-damp and benefiting joints; the semen plantaginis has the effects of clearing heat, promoting urination and discharging turbidity, the achyranthes bidentata has the effects of clearing heat, removing toxicity, removing dampness and discharging turbidity, and the bighead atractylodes rhizome has the effects of tonifying spleen, promoting urination and removing dampness, and promotes purine metabolism and uric acid excretion.

The largehead atractylodes rhizome and the astragalus root tonify qi of lung and spleen, and the astragalus root and the angelica root tonify qi and nourish blood, and are mutually compatible to enhance the immunity of the organism. The combination of radix astragali and radix Puerariae can strengthen yang and qi, and enhance the functions of descending foul smell and ascending clear qi. The atractylodes, the yam and the astragalus root have the effects of tonifying spleen and removing dampness, and the yam have the effects of reducing phlegm and relieving cough, and can reduce the generation of phlegm-dampness.

Prepared rehmannia root has the effects of tonifying liver and blood, achyranthes root has the effects of tonifying liver and kidney, strengthening tendons and bones, Chinese yam has the effects of tonifying spleen and kidney and homology of liver and kidney, and the effect of tonifying liver and kidney is reflected.

Scorpio has effects in expelling pathogenic wind, dredging collaterals, removing toxic materials, relieving swelling, and relieving pain; turmeric, achyranthes root, Chinese angelica and sargentgloryvine stem have the effects of activating blood and dissolving stasis, and activating blood and nourishing blood; herba Siegesbeckiae, Ningpo Yam rhizome, and rhizoma Smilacis Glabrae have effects in promoting blood circulation, dredging collaterals, dispelling pathogenic wind, removing dampness, and easing joint movement; it is combined with Gui Zhi to warm and dredge meridians and promote blood circulation in joints. The combination of Huang Qi and Jiang Huang can tonify qi and activate blood, so that Jiang Huang can activate blood without damaging healthy qi.

The prescription is prepared from radix puerariae and cassia twig, and has the effects of enhancing the excretion of turbid toxin, tonifying qi, invigorating yang, promoting blood circulation and dispelling wind-damp.

The method comprises the following steps: tonifying five internal organs, enhancing the immunity of the organism, clearing away heat and toxic materials, promoting diuresis, discharging turbidity, removing blood stasis, eliminating phlegm, dispelling wind-damp, benefiting joints, dredging collaterals and relieving pain. The compatibility of the recipe is characterized by coordinating the functions of the five internal organs and having obvious effects of detoxifying and purging turbidity.

1. Data and method

1.1 general data application clinical trials of the invention: the experiment adopts the data of diagnosing and treating the gouty arthritis in the Qingchuan county traditional Chinese medicine hospital from 1 month in 2019 to 6 months in 2021, which are all primary gout, and the course of the disease is 3-15 days. Randomly divided into 2 groups, 25 treatment groups, 17 men and 8 women; the age is 35-75 years, and the average age is 48 years. Control group 25, male 15, female 10; the age is 35-75 years, and the average age is 45 years. Two groups of general data are similar (p > 0.05).

1.2 the diagnosis standard refers to the handbook on immune rheumatism diagnosis and differential diagnosis compiled by the king golden armor, the acute disease is caused, the disease is developed in the middle of the night, the asymmetric arthritis of the lower limbs, the 1 st metatarsophalangeal joint is the first joint, the obvious red swelling and pain of the thumb, knee, ankle, wrist, elbow joint and soft tissue around the joint are caused in 90 percent of cases, the blood uric acid is more than 416mmol/L, the soft tissue swelling around the joint can be seen by X-ray, and even the bone near the joint can be seen to puncture and chisel, worm erosion and the like.

1.3 methods of treatment: decocting with water 1 dose 900ml per day, and orally administering 200ml each time for 3 times; 300ml remained every day, and the pain joint is applied with damp (hot) for 2 times; 7 days is a course of treatment, and the curative effect is observed after 2 courses of treatment. The control group is orally administered with colchicine 1mg for the first time, and 0.5mg in 2 hr thereafter, with a total amount of 6-8mg per day, and is stopped for 24-48 hr or when gastrointestinal symptoms such as vomiting and diarrhea appear; indomethacin 25mg is taken orally, 3 times daily, and is stopped after pain subsides; sodium bicarbonate 1g is taken orally 3 times a day, and is stopped when the urine pH value is higher than 6.5. The effect was assessed after 15 days of treatment in both groups.

1.4 evaluation of therapeutic effect was made according to "practical internal medicine". And (3) healing: the symptom signs disappear, and the blood uric acid falls to a normal range. The method has the following advantages: the symptoms and physical signs are reduced, and the blood uric acid is close to the normal value. And (4) invalidation: the symptoms and physical signs are not obviously relieved, and the blood uric acid is higher than the normal value.

1.5 statistical treatment X2 test and t test were used.

2. As a result:

the treatment group has 25 cases, 5 cases are cured, 14 cases are effective, 1 case is ineffective, and the total effective rate is 96%; in 25 control groups, 2 cases are cured, 21 cases are effective, 2 cases are ineffective, and the total effective rate is 92%. Two groups of differences were not significant (p > 0.05). In 25 cases of treatment, no gastrointestinal symptoms appeared; in the control group, 25 cases showed symptoms of abdominal pain, vomiting and diarrhea in 5 cases, discomfort in the gastric cavity in 15 cases, and no symptoms in 5 cases.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims (1)

1. The formula for treating gouty arthritis through oral administration and external washing is characterized by being prepared from the following raw materials in parts by weight: 15g of Chinese pulsatilla root, 30g of rabdosia rubescens, 15g of siegesbeckia orientalis, 15g of yam, 30g of glabrous greenbrier rhizome, 30g of kudzuvine root, 30g of sargentgloryvine stem, 15g of Chinese angelica, 20g of prepared rehmannia root, 30g of Chinese yam, 15g of radix achyranthis bidentatae, 15g of plantain seed, 15g of largehead atractylodes rhizome, 30g of astragalus, 12g of turmeric, 12g of cassia twig and 6g of scorpion.