CN114306270A - Compound taxol capsule and tablet preparation method and process - Google Patents
Compound taxol capsule and tablet preparation method and process Download PDFInfo
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- CN114306270A CN114306270A CN202110436443.5A CN202110436443A CN114306270A CN 114306270 A CN114306270 A CN 114306270A CN 202110436443 A CN202110436443 A CN 202110436443A CN 114306270 A CN114306270 A CN 114306270A
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Abstract
The invention discloses a method and a process for preparing compound taxol anticancer capsule tablets, which comprises the following steps: step 1: remove the impurity, dispose the attached earth and other impurity of yew branch and leaf skin surface to effectual germ, the mycotic of yew branch and leaf skin surface and the residue of chemical fertilizer pesticide are disposed, step 2: slicing, slicing the removed Japanese Yew bole, and pulverizing into 3-5cm pieces. Has the advantages that: the invention greatly improves the yield of the taxol extract in the taxol anticancer capsule tablet by adopting modes of ultrafiltration extraction, concentration and the like, and simultaneously carries out detoxification before the processing by an ultrafiltration method and secondary detoxification after the processing, so that the toxicity of the taxol in the tablet is reduced by more than 98 percent, the effective activity is not damaged, the operation is simple, and the treatment effect and the safety of the taxol anticancer capsule tablet are greatly improved.
Description
Technical Field
The invention relates to the technical field of Chinese herbal medicines, in particular to a method and a process for preparing compound taxol anticancer capsules.
Background
Paclitaxel is the most potent anticancer drug with the strongest anticancer activity among all plant anticancer drugs and alkaloids, so in recent years, capsules and tablets prepared by using extracted paclitaxel are widely used in cancer treatment.
The production process of nontoxic taxol extraction from taxus chinensis adopts various extraction process modes such as extraction, ultrasonic extraction and the like in relevant reports at home and abroad and related documents at present; although the extraction and ultrasonic extraction processes are advanced and the extraction rate is high, the loss of cancer-suppressing active substances in paclitaxel is more, research and experiments show that the paclitaxel extracted in a non-toxic manner is better than the toxic paclitaxel, the physiological activity is still stronger, and the non-toxic extraction retains a plurality of cancer-suppressing active substances, especially small molecular compounds in pigment of sequoia japonica, which is very important for relieving cancer pain and suppressing the growth of cancer cells, however, the non-toxic extraction process is not common at home at present.
Disclosure of Invention
The invention aims to solve the problems and provide a method and a process for preparing compound paclitaxel anticancer capsules.
The invention realizes the purpose through the following technical scheme:
the compound taxol anticancer capsule preparation method and the process thereof comprise the following steps:
step 1: removing impurities
Soil and other impurities attached to the surfaces of the branches and leaves of the taxus chinensis are removed, so that germs, mildew and pesticide residues on the surfaces of the branches and leaves of the taxus chinensis can be effectively removed;
step 2: slicing
Cutting the removed Japanese Yew bole into slices, and pulverizing to 3-5 cm;
and step 3: drying by baking
Feeding the taxus chinensis slices into a hot air circulation dryer to be dried for 2 hours;
and 4, step 4: pulverizing
Crushing the dried taxus chinensis fragments into 10-20 meshes by a stainless steel crusher;
and 5: wall breaking by ultramicro nanoparticles
Pulverizing Taxus chinensis fragments to below 300 mesh by ultramicro nanoscale wall breaking machine;
step 6: peeling off by soaking in ethanol
Because the taxane diterpenoid is insoluble in water and easily soluble in ethanol, the taxus chinensis is soaked in 30 percent of 95 percent medical ethanol and 70 percent aqueous solvent according to the proportion of 1:4, after the taxus chinensis is soaked for 24 hours by indirect heating, the liquid temperature is indirectly heated to the range of the stable physiological activity of the diterpenoid, and the mixture is rapidly stirred for 20 minutes to promote the stripping of the alkane diterpenoid in the flow phase impact at the proper temperature;
and 7: primary filter
Filtering the stirred and stripped solution by using a filter screen with the fineness of 500 meshes, and soaking filter residues in 30 percent ethanol and 70 percent hydrosolvent for the second time;
and 8: detoxification treatment
Indirectly heating the solution after primary filtration to appropriate temperature, gradually increasing liquid temperature, gradually floating toxic light volatile oil on the surface of ethanol solution, and accumulating to the center with temperature increase, adsorbing with oil-absorbing paper, or taking out with stainless steel spoon, and concentrating to extract volatile oil in the future;
and step 9: low pressure macroporous ultrafiltration
Setting the granularity to be 0.01um and the granularity of the taxane diterpenoid compound to be 0.01-0.002um by adopting an ultrafiltration membrane separator; therefore, firstly, the detoxified ethanol solution is pressurized and ultrafiltered and intercepted by 0.01um of low-pressure macropores, and the intercepted substances are large molecules with no utilization value, such as crude fibers, tiny dust, colloid and the like;
step 10: high pressure small hole ultra-filtration
Intercepting the low-pressure macroporous permeate liquid by high-pressure small holes of 0.001um to obtain large and small molecule concentrated solutions of taxane diterpene and other compounds;
step 11: vacuum permeation concentration by chromatography
Combining the eluent of the high-pressure small-hole ultrafiltration permeate through the silica gel chromatography column in the vacuum state and the large and small molecule concentrated solution intercepted by the high-pressure small-hole ultrafiltration, and carrying out medium-temperature vacuum infiltration and concentration on the combined concentrated solution for 2 hours to obtain a paste after the large and small molecules are combined;
step 12: recovery of ethanol
Mixing the vacuum-permeated small molecular ethanol solution and the chromatographically permeated small molecular ethanol solution, and distilling and recycling the mixture by using a distiller;
step 13: secondary detoxification
Pouring the vacuum permeation concentrated paste into a thin-wall stainless steel disc, sending into a constant-temperature drying oven, sealing, sucking air, and drying for 3 hr, wherein the concentrated paste contains part of light Douglas fir essential oil and ethanol, when the paste temperature gradually rises, Douglas fir essential oil will sublimate and evaporate with ethanol, and after 3 hr, no ethanol crystal can be presented;
step 14: low temperature vacuum drying
Crushing the basically dry ethanol-free crystal, putting into another thin-wall stainless steel plate, and freeze-drying in a vacuum freeze-drying machine at a low temperature of more than 38 deg.C under vacuum for 12 hr to obtain nontoxic paclitaxel crystal (extract);
step 15: crushing of crystals
Rapidly pulverizing the dried crystal into 80 mesh by stainless steel high speed pulverizer to obtain paclitaxel extract, wherein the color is light red irregular crystal powder, and the content of paclitaxel is determined to be 30%;
step 16: preparation of Capsule tablets
The paclitaxel extract after extraction and drying is respectively prepared into capsule tablets according to the specifications of 0.066 g/capsule and 0.037 g/capsule, and then the compound paclitaxel anticancer capsule tablets can be prepared.
Furthermore, the purpose of the nano ultramicro wall breaking in the step 5 is that because the small molecular compounds of the taxane diterpene category are tightly attached to the inner nucleus and the outer nucleus of the cell, and the cytocolloid and the adhesive force are strong, even if the small molecular compounds are soaked in ethanol and expand and crack, part of alkane diterpene compounds can not be released, and the diterpene and other compounds can be effectively obtained after the wall breaking by adopting an ultramicro nanoscale wall breaking machine.
Furthermore, the physical state and the physicochemical property of the paclitaxel extract prepared by the invention are as follows: the paclitaxel extract contains protein, amino acids, minerals, biotin, taxane diterpenes, taxine, taxol, taxuspolysaccharide, taxol red pigment, taxol tannin, taxus polyphenol, taxus adenosine and other compounds, and has the advantages of high viscosity, light red crystalline powder, slightly bitter and astringent taste, and the smell of the pine and fir; the paclitaxel extract is easy to absorb moisture, the viscosity is increased when the temperature is higher than 15 ℃, viscous fluid is gradually formed, when the temperature is reduced to below 5 ℃, the paclitaxel extract is reduced into crystal blocks, the physiological activity of the paclitaxel extract is unchanged through detection, but microorganisms are increased, and when the paclitaxel extract is refrigerated or frozen at a low temperature below zero, the physical state and the physicochemical indexes of the paclitaxel extract are relatively stable.
Further, the use method of the compound paclitaxel anticancer capsule tablet is as follows: when the content of each capsule is 0.066 g multiplied by 60 capsules/bottle and the net content is 3.96 g per bottle, the compound paclitaxel capsule is taken three times a day, 2 capsules are taken each time, 6 capsules are taken each time, and 30 days are a course of treatment (three bottles); the compound paclitaxel tablet has a content of 0.037 g × 90 tablet/bottle per tablet and a net content of 3.33 g per bottle, and is taken three times a day, three tablets are taken each time, 9 tablets are taken each day, and 30 days is a course of treatment (three bottles).
Further, after C57BL/6 mice were inoculated with Lewis lung cancer cells, they were randomly divided into four dose groups of model group, positive control group, Taxus chinensis extract 0.92, 0.46, 0.23 and 0.11g body weight; respectively intragastrically administering the corresponding dose of the Chinese yew extract for 1 time per day for 14 days; the positive control group is administered with fluorouracil 3 times by intragastric administration, and the dosage of each administration is 50mg of body weight; the result shows that the yew extract with the weight dose of 0.92g has certain inhibition effect on the growth of Lewis lung cancer tumor of mice, and the inhibition rate is 61.6%. Fluorouracil significantly reduced the white blood cell count, thymus and spleen indices in mice, while the dose groups of the taxus extract had no significant effect.
Further, the main action mechanism of the paclitaxel anticancer capsule tablet is as follows: after paclitaxel and cell receptor, the released TNF-a inhibitor enters into cell nucleus through new hair capillary and cell membrane of tumor to promote the polymerization of tumor microtubule, and does not react with unpolymerized tubulin self-dimer; the inhibitor TNF-a accumulates a large amount of microtubules, also called protein gene inhibitors, in cancer cells, the accumulation of the microtubules interferes with and destroys the gene immune and repair response functions of the cancer cells, particularly stops cancer cell division in mitosis G2/m, leads rapidly dividing tumor cells to be firmly fixed in the mitosis stage, prevents the cancer cells from growing and replicating rapidly, and induces and kills the cancer cells by resisting the dynamic equilibrium of tubulin and dimer, thus leading the tumor cells to atrophy and apoptosis.
The invention has the beneficial effects that:
the invention greatly improves the yield of the taxol extract in the taxol anticancer capsule tablet by adopting modes of ultrafiltration extraction, concentration and the like, and simultaneously carries out detoxification before the processing by an ultrafiltration method and secondary detoxification after the processing, so that the toxicity of the taxol in the tablet is reduced by more than 98 percent, the effective activity is not damaged, the operation is simple, and the treatment effect and the safety of the taxol anticancer capsule tablet are greatly improved.
Drawings
FIG. 1 is a process flow diagram of the compound paclitaxel anticancer capsule tablet preparation method and process of the present invention.
Detailed Description
The compound taxol anticancer capsule preparation method and the process thereof comprise the following steps:
step 1: removing impurities
Soil and other impurities attached to the surfaces of the branches and leaves of the taxus chinensis are removed, so that germs, mildew and pesticide residues on the surfaces of the branches and leaves of the taxus chinensis can be effectively removed;
step 2: slicing
Cutting the removed Japanese Yew bole into slices, and pulverizing to 3-5 cm;
and step 3: drying by baking
Feeding the taxus chinensis slices into a hot air circulation dryer to be dried for 2 hours;
and 4, step 4: pulverizing
Crushing the dried taxus chinensis fragments into 10-20 meshes by a stainless steel crusher;
and 5: wall breaking by ultramicro nanoparticles
Pulverizing Taxus chinensis fragments to below 300 mesh by ultramicro nanoscale wall breaking machine;
step 6: peeling off by soaking in ethanol
Because the taxane diterpenoid is insoluble in water and easily soluble in ethanol, the taxus chinensis is soaked in 30 percent of 95 percent medical ethanol and 70 percent aqueous solvent according to the proportion of 1:4, after the taxus chinensis is soaked for 24 hours by indirect heating, the liquid temperature is indirectly heated to the range of the stable physiological activity of the diterpenoid, and the mixture is rapidly stirred for 20 minutes to promote the stripping of the alkane diterpenoid in the flow phase impact at the proper temperature;
and 7: primary filter
Filtering the stirred and stripped solution by using a filter screen with the fineness of 500 meshes, and soaking filter residues in 30 percent ethanol and 70 percent hydrosolvent for the second time;
and 8: detoxification treatment
Indirectly heating the solution after primary filtration to appropriate temperature, gradually increasing liquid temperature, gradually floating toxic light volatile oil on the surface of ethanol solution, and accumulating to the center with temperature increase, adsorbing with oil-absorbing paper, or taking out with stainless steel spoon, and concentrating to extract volatile oil in the future;
and step 9: low pressure macroporous ultrafiltration
Setting the granularity to be 0.01um and the granularity of the taxane diterpenoid compound to be 0.01-0.002um by adopting an ultrafiltration membrane separator; therefore, firstly, the detoxified ethanol solution is pressurized and ultrafiltered and intercepted by 0.01um of low-pressure macropores, and the intercepted substances are large molecules with no utilization value, such as crude fibers, tiny dust, colloid and the like;
step 10: high pressure small hole ultra-filtration
Intercepting the low-pressure macroporous permeate liquid by high-pressure small holes of 0.001um to obtain large and small molecule concentrated solutions of taxane diterpene and other compounds;
step 11: vacuum permeation concentration by chromatography
Combining the eluent of the high-pressure small-hole ultrafiltration permeate through the silica gel chromatography column in the vacuum state and the large and small molecule concentrated solution intercepted by the high-pressure small-hole ultrafiltration, and carrying out medium-temperature vacuum infiltration and concentration on the combined concentrated solution for 2 hours to obtain a paste after the large and small molecules are combined;
step 12: recovery of ethanol
Mixing the vacuum-permeated small molecular ethanol solution and the chromatographically permeated small molecular ethanol solution, and distilling and recycling the mixture by using a distiller;
step 13: secondary detoxification
Pouring the vacuum permeation concentrated paste into a thin-wall stainless steel disc, sending into a constant-temperature drying oven, sealing, sucking air, and drying for 3 hr, wherein the concentrated paste contains part of light Douglas fir essential oil and ethanol, when the paste temperature gradually rises, Douglas fir essential oil will sublimate and evaporate with ethanol, and after 3 hr, no ethanol crystal can be presented;
step 14: low temperature vacuum drying
Crushing the basically dry ethanol-free crystal, putting into another thin-wall stainless steel plate, and freeze-drying in a vacuum freeze-drying machine at a low temperature of more than 38 deg.C under vacuum for 12 hr to obtain nontoxic paclitaxel crystal (extract);
step 15: crushing of crystals
Rapidly pulverizing the dried crystal into 80 mesh by stainless steel high speed pulverizer to obtain paclitaxel extract, wherein the color is light red irregular crystal powder, and the content of paclitaxel is determined to be 30%;
step 16: preparation of Capsule tablets
The paclitaxel extract after extraction and drying is respectively prepared into capsule tablets according to the specifications of 0.066 g/capsule and 0.037 g/capsule, and then the compound paclitaxel anticancer capsule tablets can be prepared.
In this embodiment, the purpose of the nano ultra-micro wall-breaking in step 5 is that, because the small molecular compounds of taxane diterpenes are tightly attached to the inside and outside of the nucleus, and the cytocolloid and the adhesive force are strong, even if the small molecular compounds are swelled and cracked after being soaked in ethanol, part of alkane diterpenes cannot be released, and diterpenes and other compounds can be effectively obtained after wall-breaking by using an ultra-micro nano wall-breaking machine.
In this embodiment, the physical state and physicochemical properties of the paclitaxel extract prepared by the present invention are as follows: the paclitaxel extract contains protein, amino acids, minerals, biotin, taxane diterpenes, taxine, taxol, taxuspolysaccharide, taxol red pigment, taxol tannin, taxus polyphenol, taxus adenosine and other compounds, and has the advantages of high viscosity, light red crystalline powder, slightly bitter and astringent taste, and the smell of the pine and fir; the paclitaxel extract is easy to absorb moisture, the viscosity is increased when the temperature is higher than 15 ℃, viscous fluid is gradually formed, when the temperature is reduced to below 5 ℃, the paclitaxel extract is reduced into crystal blocks, the physiological activity of the paclitaxel extract is unchanged through detection, but microorganisms are increased, and when the paclitaxel extract is refrigerated or frozen at a low temperature below zero, the physical state and the physicochemical indexes of the paclitaxel extract are relatively stable.
In the embodiment, the use method of the compound paclitaxel anticancer capsule tablet is as follows: when the content of each capsule is 0.066 g multiplied by 60 capsules/bottle and the net content is 3.96 g per bottle, the compound paclitaxel capsule is taken three times a day, 2 capsules are taken each time, 6 capsules are taken each time, and 30 days are a course of treatment (three bottles); the compound paclitaxel tablet has a content of 0.037 g × 90 tablet/bottle per tablet and a net content of 3.33 g per bottle, and is taken three times a day, three tablets are taken each time, 9 tablets are taken each day, and 30 days is a course of treatment (three bottles).
In the embodiment, after the C57BL/6 mouse is inoculated with Lewis lung cancer cells, the mouse is randomly divided into four dose groups of a model group, a positive control group, a taxus chinensis extract, 0.92, 0.46, 0.23 and 0.11g of body weight; respectively intragastrically administering the corresponding dose of the Chinese yew extract for 1 time per day for 14 days; the positive control group is administered with fluorouracil 3 times by intragastric administration, and the dosage of each administration is 50mg of body weight; the result shows that the yew extract with the weight dose of 0.92g has certain inhibition effect on the growth of Lewis lung cancer tumor of mice, and the inhibition rate is 61.6%. Fluorouracil significantly reduced the white blood cell count, thymus and spleen indices in mice, while the dose groups of the taxus extract had no significant effect.
In this embodiment, the main mechanism of action of the paclitaxel anticancer capsule tablet is as follows: after paclitaxel and cell receptor, the released TNF-a inhibitor enters into cell nucleus through new hair capillary and cell membrane of tumor to promote the polymerization of tumor microtubule, and does not react with unpolymerized tubulin self-dimer; the inhibitor TNF-a accumulates a large amount of microtubules, also called protein gene inhibitors, in cancer cells, the accumulation of the microtubules interferes with and destroys the gene immune and repair response functions of the cancer cells, particularly stops cancer cell division in mitosis G2/m, leads rapidly dividing tumor cells to be firmly fixed in the mitosis stage, prevents the cancer cells from growing and replicating rapidly, and induces and kills the cancer cells by resisting the dynamic equilibrium of tubulin and dimer, thus leading the tumor cells to atrophy and apoptosis.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (4)
1. The compound taxol anticancer capsule preparation method and the process thereof are characterized in that: it comprises the following steps:
step 1: removing impurities
Soil and other impurities attached to the surfaces of the branches and leaves of the taxus chinensis are removed, so that germs, mildew and pesticide residues on the surfaces of the branches and leaves of the taxus chinensis can be effectively removed;
step 2: slicing
Cutting the removed Japanese Yew bole into slices, and pulverizing to 3-5 cm;
and step 3: drying by baking
Feeding the taxus chinensis slices into a hot air circulation dryer to be dried for 2 hours;
and 4, step 4: pulverizing
Crushing the dried taxus chinensis fragments into 10-20 meshes by a stainless steel crusher;
and 5: wall breaking by ultramicro nanoparticles
Pulverizing Taxus chinensis fragments to below 300 mesh by ultramicro nanoscale wall breaking machine;
step 6: peeling off by soaking in ethanol
Because the taxane diterpenoid is insoluble in water and easily soluble in ethanol, the taxus chinensis is soaked in 30 percent of 95 percent medical ethanol and 70 percent aqueous solvent according to the proportion of 1:4, after the taxus chinensis is soaked for 24 hours by indirect heating, the liquid temperature is indirectly heated to the range of the stable physiological activity of the diterpenoid, and the mixture is rapidly stirred for 20 minutes to promote the stripping of the alkane diterpenoid in the flow phase impact at the proper temperature;
and 7: primary filter
Filtering the stirred and stripped solution by using a filter screen with the fineness of 500 meshes, and soaking filter residues in 30 percent ethanol and 70 percent hydrosolvent for the second time;
and 8: detoxification treatment
Indirectly heating the solution after primary filtration to appropriate temperature, gradually increasing liquid temperature, gradually floating toxic light volatile oil on the surface of ethanol solution, and accumulating to the center with temperature increase, adsorbing with oil-absorbing paper, or taking out with stainless steel spoon, and concentrating to extract volatile oil in the future;
and step 9: low pressure macroporous ultrafiltration
Setting the granularity to be 0.01um and the granularity of the taxane diterpenoid compound to be 0.01-0.002um by adopting an ultrafiltration membrane separator; therefore, firstly, the detoxified ethanol solution is pressurized and ultrafiltered and intercepted by 0.01um of low-pressure macropores, and the intercepted substances are large molecules with no utilization value, such as crude fibers, tiny dust, colloid and the like;
step 10: high pressure small hole ultra-filtration
Intercepting the low-pressure macroporous permeate liquid by high-pressure small holes of 0.001um to obtain large and small molecule concentrated solutions of taxane diterpene and other compounds;
step 11: vacuum permeation concentration by chromatography
Combining the eluent of the high-pressure small-hole ultrafiltration permeate through the silica gel chromatography column in the vacuum state and the large and small molecule concentrated solution intercepted by the high-pressure small-hole ultrafiltration, and carrying out medium-temperature vacuum infiltration and concentration on the combined concentrated solution for 2 hours to obtain a paste after the large and small molecules are combined;
step 12: recovery of ethanol
Mixing the vacuum-permeated small molecular ethanol solution and the chromatographically permeated small molecular ethanol solution, and distilling and recycling the mixture by using a distiller;
step 13: secondary detoxification
Pouring the vacuum permeation concentrated paste into a thin-wall stainless steel disc, sending into a constant-temperature drying oven, sealing, sucking air, and drying for 3 hr, wherein the concentrated paste contains part of light Douglas fir essential oil and ethanol, when the paste temperature gradually rises, Douglas fir essential oil will sublimate and evaporate with ethanol, and after 3 hr, no ethanol crystal can be presented;
step 14: low temperature vacuum drying
Crushing the basically dry ethanol-free crystal, putting into another thin-wall stainless steel plate, and freeze-drying in a vacuum freeze-drying machine at a low temperature of more than 38 deg.C under vacuum for 12 hr to obtain nontoxic paclitaxel crystal (extract);
step 15: crushing of crystals
Rapidly pulverizing the dried crystal into 80 mesh by stainless steel high speed pulverizer to obtain paclitaxel extract, wherein the color is light red irregular crystal powder, and the content of paclitaxel is determined to be 30%;
step 16: preparation of Capsule tablets
The paclitaxel extract after extraction and drying is respectively prepared into capsule tablets according to the specifications of 0.066 g/capsule and 0.037 g/capsule, and then the compound paclitaxel anticancer capsule tablets can be prepared.
2. The method and process for preparing compound paclitaxel anticancer capsule tablet according to claim 1, wherein: the purpose of the nanometer ultramicro wall breaking in the step 5 is that because the small molecular compounds of the taxane diterpenoid are tightly attached to the inner nucleus and the outer nucleus of the cell, and the cytocolloid and the adhesive force are strong, even if the small molecular compounds are expanded and cracked after being soaked in the ethanol, part of alkane diterpenoid compounds can not be dissociated, and the diterpenoid and other compounds can be effectively obtained after the wall breaking by adopting an ultramicro nanometer wall breaking machine.
3. The method and process for preparing compound paclitaxel anticancer capsule tablet according to claim 1, wherein: the physical state and physicochemical properties of the paclitaxel extract prepared by the invention are as follows: the paclitaxel extract contains protein, amino acids, minerals, biotin, taxane diterpenes, taxine, taxol, taxuspolysaccharide, taxol red pigment, taxol tannin, taxus polyphenol, taxus adenosine and other compounds, and has the advantages of high viscosity, light red crystalline powder, slightly bitter and astringent taste, and the smell of the pine and fir; the paclitaxel extract is easy to absorb moisture, the viscosity is increased when the temperature is higher than 15 ℃, viscous fluid is gradually formed, when the temperature is reduced to below 5 ℃, the paclitaxel extract is reduced into crystal blocks, the physiological activity of the paclitaxel extract is unchanged through detection, but microorganisms are increased, and when the paclitaxel extract is refrigerated or frozen at a low temperature below zero, the physical state and the physicochemical indexes of the paclitaxel extract are relatively stable.
4. The method and process for preparing compound paclitaxel anticancer capsule tablet according to claim 1, wherein: the application method of the compound paclitaxel anticancer capsule tablet comprises the following steps: when the content of each capsule is 0.066 g multiplied by 60 capsules/bottle and the net content is 3.96 g per bottle, the compound paclitaxel capsule is taken three times a day, 2 capsules are taken each time, 6 capsules are taken each time, and 30 days are a course of treatment (three bottles); the compound paclitaxel tablet has a content of 0.037 g × 90 tablet/bottle per tablet and a net content of 3.33 g per bottle, and is taken three times a day, three tablets are taken each time, 9 tablets are taken each day, and 30 days is a course of treatment (three bottles).
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225262A (en) * | 1998-12-09 | 1999-08-11 | 延边香料研究所 | Anti cancer drug contg. taxals alcohol |
| CN101474164A (en) * | 2008-12-22 | 2009-07-08 | 郭涛 | Oral compound paclitaxel capsule and preparation method |
| CN102552338A (en) * | 2012-02-13 | 2012-07-11 | 林树芳 | Paclitaxel oral anticancer preparation obtained by nontoxic extraction from complete stool of Chinese yew and preparation method thereof |
| CN107827843A (en) * | 2017-11-23 | 2018-03-23 | 华益药业科技(安徽)有限公司 | A kind of taxanes oral liquid and preparation method thereof |
-
2021
- 2021-04-22 CN CN202110436443.5A patent/CN114306270A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225262A (en) * | 1998-12-09 | 1999-08-11 | 延边香料研究所 | Anti cancer drug contg. taxals alcohol |
| CN101474164A (en) * | 2008-12-22 | 2009-07-08 | 郭涛 | Oral compound paclitaxel capsule and preparation method |
| CN102552338A (en) * | 2012-02-13 | 2012-07-11 | 林树芳 | Paclitaxel oral anticancer preparation obtained by nontoxic extraction from complete stool of Chinese yew and preparation method thereof |
| CN107827843A (en) * | 2017-11-23 | 2018-03-23 | 华益药业科技(安徽)有限公司 | A kind of taxanes oral liquid and preparation method thereof |
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