CN114304466A - Experimental microwave sterilization device and sterilization method - Google Patents
Experimental microwave sterilization device and sterilization method Download PDFInfo
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- CN114304466A CN114304466A CN202210037052.0A CN202210037052A CN114304466A CN 114304466 A CN114304466 A CN 114304466A CN 202210037052 A CN202210037052 A CN 202210037052A CN 114304466 A CN114304466 A CN 114304466A
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- capillary tube
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- sterilized
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 75
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 19
- 239000012530 fluid Substances 0.000 claims abstract description 59
- 238000010438 heat treatment Methods 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 4
- 230000035515 penetration Effects 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- -1 polytetrafluoroethylene Polymers 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000084 colloidal system Substances 0.000 abstract description 4
- 239000000796 flavoring agent Substances 0.000 abstract description 4
- 235000019634 flavors Nutrition 0.000 abstract description 4
- 235000013601 eggs Nutrition 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000009928 pasteurization Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000012827 research and development Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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Abstract
The invention provides an experimental microwave sterilization device, which is used for sterilizing a small amount of fluid and comprises a microwave heating cavity, wherein a capillary tube for allowing the fluid to be sterilized to pass through is arranged in the microwave heating cavity, a capillary tube inlet and a capillary tube outlet are arranged at an inlet and an outlet of the microwave heating cavity, the capillary tube inlet is connected with a first container for containing the fluid to be sterilized, the capillary tube outlet is connected with a second container for containing the sterilized fluid, and a fluid pump is also arranged between the capillary tube inlet and the first container; the treatment capacity of the fluid to be sterilized is less than 100 ml/min. The experimental microwave sterilization device and the experimental microwave sterilization method provided by the invention are suitable for a method for sterilizing a small amount of fluid, and the fluid is sterilized by microwaves at a relatively low temperature by utilizing the heat effect and the non-heat effect of microwave sterilization, so that the loss of heat-sensitive components in the fluid is reduced, and the flavor and the colloid interface characteristic of the fluid are better maintained.
Description
Technical Field
The invention belongs to the technical field of fluid food and drug production and research and development, and particularly relates to an experimental microwave sterilization device and a sterilization method.
Background
Before filling, liquid food and medicine usually needs to be sterilized. The existing methods use high temperature flash sterilization, pasteurization, etc. to treat the fluid. In this method, the fluid is kept at a high temperature for a relatively long time, and the fluid is also subjected to a relatively high temperature. Can cause great loss of heat-sensitive components in the fluid and affect the flavor and the colloid interface characteristics of the product.
For the conventional pasteurization of eggs, such as pasteurized eggs, the conventional sterilization devices basically sterilize the eggs by heat conduction between the egg liquid and hot water. The hot water used for pasteurizing the egg liquid needs to be heated to 135 ℃ under 3 atmospheric pressures to achieve effective sterilization effect. And the heating effect is uneven, so that the quality of the peripheral egg liquid is reduced when the central egg liquid is fully sterilized, and the aim of completely heating and sterilizing is often difficult to achieve. The heated hot water needs to be reheated for reuse. The use of a large amount of hot water wastes resources and is easy to cause accidents.
For ultrahigh temperature instant sterilization commonly used for fluids, the existing equipment also has the pasteurization defect, and meanwhile, because the equipment manufacture utilizes the heat conduction principle, miniaturization is difficult to realize, and the minimum required sample amount of the existing experimental equipment is about 4-5L, which is a bottleneck difficult to exceed for laboratory research and development, especially for components with high value in fluid composition or components which are difficult to commercialize in large quantities, so that commercial development of many fluid foods and medicines or preparation of experimental samples are stuck in the sterilization link.
Disclosure of Invention
In view of the above, the present invention is directed to an experimental microwave sterilization apparatus and a sterilization method, which solve the technical problem that the minimum sample throughput of the existing experimental sterilization apparatus cannot satisfy the requirement of the components containing high-value components or the components that are not yet easily commercialized in large quantities.
In a first aspect, the invention provides an experimental microwave sterilization device, which is used for sterilizing a small amount of fluid and comprises a microwave heating cavity, wherein a capillary tube for allowing the fluid to be sterilized to pass through is arranged in the microwave heating cavity, and a capillary tube inlet and a capillary tube outlet are arranged at an inlet and an outlet of the microwave heating cavity, the capillary tube inlet is connected with a first container for containing the fluid to be sterilized, the capillary tube outlet is connected with a second container for containing the sterilized fluid, and a fluid pump is further arranged between the capillary tube inlet and the first container; the treatment capacity of the fluid to be sterilized is less than 100 ml/min.
Preferably, the capillary is a capillary having an inner diameter less than the penetration depth of the microwaves.
Preferably, the capillary tube is made of a high-temperature-resistant and high-pressure-resistant polymer material, including polyetheretherketone and polytetrafluoroethylene.
Preferably, the capillary tube is a spirally arranged coil with the length of 500-2000mm and the diameter of 150-200 mm.
Preferably, the fluid pump is a precision constant flow pump, the highest pressure bearing of the precision constant flow pump is 10MPa, and the flow rate is 0.1-100 mL/min.
In a second aspect, the present invention further provides a sterilization method based on the experimental microwave sterilization device, wherein the fluid to be sterilized in the first container is conveyed to the microwave heating chamber through the fluid pump connected with the capillary tube for microwave sterilization, and is collected in the second container.
Preferably, the disinfecting wash is performed by running with water or a disinfecting liquid before or after the disinfecting.
In a third aspect, the invention also provides an application of the experimental microwave sterilization device in testing of fluid food and medicines.
Compared with the prior art, the invention has the beneficial effects that:
(1) the experimental microwave sterilization device and the experimental microwave sterilization method provided by the invention are suitable for a method for sterilizing a small amount of fluid, and the fluid is sterilized by microwaves at a relatively low temperature by utilizing the heat effect and the non-heat effect of microwave sterilization, so that the loss of heat-sensitive components in the fluid is reduced, and the flavor and the colloid interface characteristic of the fluid are better maintained.
(2) The sterilization method has the advantages of small sample requirement, reduced sterilization temperature, and wide application in pasteurization, high temperature sterilization, and ultrahigh temperature instantaneous sterilization.
(3) The sterilization device has the advantages of small sample requirement, small manufacturing difficulty, low manufacturing cost, low running cost, simple cleaning, multiple purposes and the like.
Drawings
Fig. 1 is a schematic structural diagram of an experimental microwave sterilization device according to the present invention.
Detailed Description
The present invention is further described below in conjunction with the following embodiments and the accompanying drawings, it being understood that the drawings and the following embodiments are illustrative of the invention only and are not limiting thereof.
The invention provides an experimental microwave sterilization device, which is used for sterilizing a small amount of fluid and comprises a microwave heating cavity 5, wherein a capillary tube 3 for allowing the fluid to be sterilized to pass through is arranged in the microwave heating cavity 5, a capillary tube inlet 8 and a capillary tube outlet 9 are arranged at an inlet and an outlet of the microwave heating cavity 5, the capillary tube inlet 8 is connected with a first container 2 for containing the fluid to be sterilized, the capillary tube outlet 9 is connected with a second container 7 for containing the sterilized fluid, and a fluid pump 4 is also arranged between the capillary tube inlet 8 and the first container 2; the treatment capacity of the fluid to be sterilized is less than 100 ml/min.
In one embodiment, to ensure that the throughput of the fluid to be sterilized is sufficiently small, the capillary tube is a capillary tube with an inner diameter smaller than the penetration depth of the microwave, and the material may be a high temperature and high pressure resistant polymer material, such as polyetheretherketone or polytetrafluoroethylene. The capillary tube may be a helically arranged coil having a length of 500-2000mm and a diameter of 150-200 mm.
In one embodiment, the fluid pump can be a precision constant flow pump, the highest pressure bearing of the precision constant flow pump is 10MPa, and the flow rate is 0.1-100 mL/min.
In one embodiment, the first container 2 is placed in the clean bench 1 and the second container 7 is placed in the clean bench 6. In another embodiment, the microwave sterilization device can be integrated in the clean bench (1, 6), can be fixed beside the clean bench (1, 6), and can be pushed to the clean bench (1, 6) in use by being arranged on a bracket of a pulley.
The experimental microwave sterilization device provided by the invention integrates the cross application of a microfluid technology, a microwave heating principle and a food and drug sterilization mechanism, and ensures the accurate residence time of liquid in a microwave heating cavity through a precise constant flow pump; the fluid is conveyed through a high-temperature-resistant pressure-resistant polymer capillary tube with the microwave penetration depth larger than the inner diameter, so that the fluid is completely and directly radiated by microwaves; the length of the coiled tube in the microwave cavity is matched with the constant flow pump to obtain different sterilization time in the cavity for different sterilization needs.
The invention also provides a sterilization method based on the experimental microwave sterilization device, wherein the fluid to be sterilized in the first container 2 is conveyed to the microwave heating chamber 5 through the fluid pump 4 connected with the capillary tube 3 for microwave sterilization, and is collected in the second container 7. Before or after sterilization, the operation of water or disinfectant is used for sterilization and cleaning.
The experimental microwave sterilization device and the experimental microwave sterilization method are suitable for pasteurization, high-temperature sterilization or ultrahigh-temperature instantaneous sterilization in the test of fluid food and medicines.
The experimental microwave sterilization device and the experimental microwave sterilization method provided by the invention are suitable for a method for sterilizing a small amount of fluid, and the fluid is sterilized by microwaves at a relatively low temperature by utilizing the heat effect and the non-heat effect of microwave sterilization, so that the loss of heat-sensitive components in the fluid is reduced, and the flavor and the colloid interface characteristic of the fluid are better maintained. The sterilization device has the advantages of small sample requirement, small manufacturing difficulty, low manufacturing cost, low running cost, simple cleaning, multiple purposes and the like. The sterilization method has the advantages of small sample requirement, reduced sterilization temperature, and wide application in pasteurization, high temperature sterilization, and ultrahigh temperature instantaneous sterilization.
As the present invention may be embodied in several forms without departing from the spirit of essential characteristics thereof, the present embodiments are therefore illustrative and not restrictive, since the scope of the invention is defined by the appended claims rather than by the description herein, and all changes that fall within metes and bounds of the claims, or equivalence of such metes and bounds thereof are therefore intended to be embraced by the appended claims.
Claims (8)
1. An experimental microwave sterilization device is used for sterilizing a small amount of fluid and is characterized by comprising a microwave heating cavity, wherein a capillary tube for allowing the fluid to be sterilized to pass through is arranged in the microwave heating cavity, a capillary tube inlet and a capillary tube outlet are arranged at an inlet and an outlet of the microwave heating cavity, the capillary tube inlet is connected with a first container for containing the fluid to be sterilized, the capillary tube outlet is connected with a second container for containing the sterilized fluid, and a fluid pump is further arranged between the capillary tube inlet and the first container; the treatment capacity of the fluid to be sterilized is less than 100 ml/min.
2. The experimental microwave sterilization apparatus of claim 1, wherein the capillary tube is a capillary tube having an inner diameter smaller than a penetration depth of the microwaves.
3. The experimental microwave sterilizer of claim 1, wherein the capillary tube is made of a high temperature and pressure resistant polymer material, such as polyetheretherketone or polytetrafluoroethylene.
4. The experimental microwave sterilization device of claim 1, wherein the capillary tube is a spiral coil with a length of 500-2000mm and a diameter of 150-200 mm.
5. The experimental microwave sterilization device according to claim 1, wherein the fluid pump is a precision constant flow pump, the highest pressure bearing capacity of the precision constant flow pump is 10MPa, and the flow rate is 0.1-100 mL/min.
6. A sterilization method based on the experimental microwave sterilization apparatus as claimed in any one of claims 1 to 5, wherein the fluid to be sterilized placed in the first container is transferred to the microwave heating chamber through the fluid pump connected to the capillary tube for microwave sterilization and collected in the second container.
7. The sterilization method according to claim 6, wherein before or after the sterilization, the sterilization cleaning is performed by running with water or a sterilizing liquid.
8. Use of the experimental microwave sterilization device according to any one of claims 1-5 in testing of fluid food and pharmaceutical products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210037052.0A CN114304466A (en) | 2022-01-13 | 2022-01-13 | Experimental microwave sterilization device and sterilization method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210037052.0A CN114304466A (en) | 2022-01-13 | 2022-01-13 | Experimental microwave sterilization device and sterilization method |
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| CN114304466A true CN114304466A (en) | 2022-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210037052.0A Pending CN114304466A (en) | 2022-01-13 | 2022-01-13 | Experimental microwave sterilization device and sterilization method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201160488Y (en) * | 2008-02-03 | 2008-12-10 | 王承辉 | Microwave sterilization machine for current medium |
| CN102989020A (en) * | 2012-12-12 | 2013-03-27 | 河南勃达微波设备有限责任公司 | Microwave fluid sterilizing equipment |
| CN103891883A (en) * | 2012-12-30 | 2014-07-02 | 上海沃迪自动化装备股份有限公司 | Experiment-type microwave ultrahigh-temperature instant sterilization equipment |
| CN112450351A (en) * | 2020-12-25 | 2021-03-09 | 沈阳泽嘉科技有限公司 | Liquid spiral tube microwave sterilization equipment and sterilization method using same |
| CN216874860U (en) * | 2022-01-13 | 2022-07-05 | 伊睦(上海)流体科技有限公司 | Experimental microwave sterilization device |
-
2022
- 2022-01-13 CN CN202210037052.0A patent/CN114304466A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201160488Y (en) * | 2008-02-03 | 2008-12-10 | 王承辉 | Microwave sterilization machine for current medium |
| CN102989020A (en) * | 2012-12-12 | 2013-03-27 | 河南勃达微波设备有限责任公司 | Microwave fluid sterilizing equipment |
| CN103891883A (en) * | 2012-12-30 | 2014-07-02 | 上海沃迪自动化装备股份有限公司 | Experiment-type microwave ultrahigh-temperature instant sterilization equipment |
| CN112450351A (en) * | 2020-12-25 | 2021-03-09 | 沈阳泽嘉科技有限公司 | Liquid spiral tube microwave sterilization equipment and sterilization method using same |
| CN216874860U (en) * | 2022-01-13 | 2022-07-05 | 伊睦(上海)流体科技有限公司 | Experimental microwave sterilization device |
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