CN114287668A - Water blasting bead and preparation method, preparation device and application thereof - Google Patents
Water blasting bead and preparation method, preparation device and application thereof Download PDFInfo
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- CN114287668A CN114287668A CN202111654097.4A CN202111654097A CN114287668A CN 114287668 A CN114287668 A CN 114287668A CN 202111654097 A CN202111654097 A CN 202111654097A CN 114287668 A CN114287668 A CN 114287668A
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- Prior art keywords
- water
- aqueous solution
- sodium
- acid
- bead
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 139
- 239000011324 bead Substances 0.000 title claims abstract description 117
- 238000005422 blasting Methods 0.000 title claims abstract description 66
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 76
- 239000002840 nitric oxide donor Substances 0.000 claims abstract description 24
- 239000000110 cooling liquid Substances 0.000 claims abstract description 23
- 238000004880 explosion Methods 0.000 claims abstract description 16
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 238000005538 encapsulation Methods 0.000 claims abstract description 3
- 239000007864 aqueous solution Substances 0.000 claims description 63
- 239000007788 liquid Substances 0.000 claims description 27
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 24
- 239000004203 carnauba wax Substances 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 16
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 14
- 239000012188 paraffin wax Substances 0.000 claims description 14
- 239000001993 wax Substances 0.000 claims description 14
- 229920002545 silicone oil Polymers 0.000 claims description 13
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 12
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 12
- 235000002639 sodium chloride Nutrition 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 239000004200 microcrystalline wax Substances 0.000 claims description 10
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 10
- 239000002211 L-ascorbic acid Substances 0.000 claims description 9
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 9
- 230000000996 additive effect Effects 0.000 claims description 9
- 229960005070 ascorbic acid Drugs 0.000 claims description 9
- -1 polyethylene Polymers 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- 235000013871 bee wax Nutrition 0.000 claims description 8
- 239000012166 beeswax Substances 0.000 claims description 8
- 239000005457 ice water Substances 0.000 claims description 8
- 150000007522 mineralic acids Chemical class 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 8
- 235000017550 sodium carbonate Nutrition 0.000 claims description 8
- 239000004698 Polyethylene Substances 0.000 claims description 7
- 108010001742 S-Nitrosoglutathione Proteins 0.000 claims description 7
- HYHSBSXUHZOYLX-WDSKDSINSA-N S-nitrosoglutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O HYHSBSXUHZOYLX-WDSKDSINSA-N 0.000 claims description 7
- 229920000573 polyethylene Polymers 0.000 claims description 7
- 239000001103 potassium chloride Substances 0.000 claims description 7
- 235000011164 potassium chloride Nutrition 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 6
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 150000007529 inorganic bases Chemical class 0.000 claims description 6
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 6
- 229910017604 nitric acid Inorganic materials 0.000 claims description 6
- 150000007530 organic bases Chemical class 0.000 claims description 6
- 239000001509 sodium citrate Substances 0.000 claims description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 6
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 6
- 239000011755 sodium-L-ascorbate Substances 0.000 claims description 6
- 235000019187 sodium-L-ascorbate Nutrition 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- ZIIQCSMRQKCOCT-UHFFFAOYSA-N 2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid Chemical compound CC(=O)NC(C(O)=O)C(C)(C)SN=O ZIIQCSMRQKCOCT-UHFFFAOYSA-N 0.000 claims description 5
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- MUMXDRRTIYLYMY-YJKCNMNRSA-N (Z)-[dodecyl-[6-(dodecylazaniumyl)hexyl]amino]-oxido-oxidoiminoazanium Chemical compound CCCCCCCCCCCC[NH2+]CCCCCCN(CCCCCCCCCCCC)[N+](\[O-])=N\[O-] MUMXDRRTIYLYMY-YJKCNMNRSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 4
- 235000006408 oxalic acid Nutrition 0.000 claims description 4
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 4
- 239000011736 potassium bicarbonate Substances 0.000 claims description 4
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 4
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- 235000011181 potassium carbonates Nutrition 0.000 claims description 4
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 4
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- 229910001959 inorganic nitrate Inorganic materials 0.000 claims description 3
- 235000019809 paraffin wax Nutrition 0.000 claims description 3
- 235000019271 petrolatum Nutrition 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims description 3
- 229940039790 sodium oxalate Drugs 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229910002651 NO3 Inorganic materials 0.000 claims description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 229960004249 sodium acetate Drugs 0.000 claims description 2
- 235000019504 cigarettes Nutrition 0.000 abstract description 26
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 88
- 230000000391 smoking effect Effects 0.000 description 21
- 239000011162 core material Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 15
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 14
- 229960002715 nicotine Drugs 0.000 description 14
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 14
- 229920000742 Cotton Polymers 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 230000006378 damage Effects 0.000 description 11
- 238000012546 transfer Methods 0.000 description 8
- 239000003571 electronic cigarette Substances 0.000 description 7
- 238000007865 diluting Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000002826 coolant Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000005253 cladding Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 206010012335 Dependence Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 238000005502 peroxidation Methods 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000005586 smoking cessation Effects 0.000 description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 2
- 229960005055 sodium ascorbate Drugs 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241001539473 Euphoria Species 0.000 description 1
- 206010015535 Euphoric mood Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000021063 Respiratory fume inhalation disease Diseases 0.000 description 1
- AZFNGPAYDKGCRB-XCPIVNJJSA-M [(1s,2s)-2-amino-1,2-diphenylethyl]-(4-methylphenyl)sulfonylazanide;chlororuthenium(1+);1-methyl-4-propan-2-ylbenzene Chemical compound [Ru+]Cl.CC(C)C1=CC=C(C)C=C1.C1=CC(C)=CC=C1S(=O)(=O)[N-][C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 AZFNGPAYDKGCRB-XCPIVNJJSA-M 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000003832 immune regulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000004304 potassium nitrite Substances 0.000 description 1
- 235000010289 potassium nitrite Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000576 supplementary effect Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a water explosion bead and a preparation method, a preparation device and application thereof. The water blasting bead is prepared by dripping water or water solution into a wall material in a molten state for encapsulation, and then dripping into cooling liquid for cooling. The preparation facilities of water explodes pearl includes: dropping device, barrel, first temperature sensor, second temperature sensor, heater and cooler. The water explosion bead can be used for preparing cigarette holder contents, and can be used together with an NO donor to control the release of NO.
Description
Technical Field
The invention belongs to the technical field of bead blasting preparation, and particularly relates to a water bead blasting and a preparation method, a preparation device and application thereof.
Background
The cigarette has effects of refreshing, satisfying smoking addiction, and making smoker feel euphoria and relax. It has been shown that the cigarette containing nicotine can cause damage to the lung and is also the main cause of smoking addiction. Therefore, it is important for the health of smokers to minimize the harm of nicotine in cigarettes.
Nitric Oxide (NO) is a novel biological messenger molecule that was selected as a star molecule in 1992 by the american Science journal. NO is an extremely unstable biological free radical, has small molecules, simple structure, is gas at normal temperature, is slightly soluble in water, has fat solubility, can quickly permeate a biological membrane for diffusion, has very active chemical properties, and has important biological effects on the aspects of cardiovascular and cerebrovascular regulation, nervous system regulation, immune regulation and the like. However, NO research on the biological role of NO in the smoking process of smokers has been reported, and whether NO can be used in conjunction with cigarettes is the focus and focus of the current research.
At present, in the field of cigarette preparation, in order to avoid the problem of dry taste of smokers in the smoking process, water explosion beads are mostly adopted, essence and spice are wrapped by fat-soluble wall materials, and the essence and spice are released in a mode of crushing the explosion beads in use. CN113367383A discloses a water blasting bead, including inner core, interior cladding and outer cladding, interior cladding comprises wax powder and grease, and the grease dispersion can prevent that moisture from oozing from the wax powder clearance between the wax powder, has further played the supplementary effect of retaining water.
CN110973699A discloses a water explosion bead and a preparation method thereof, wherein the water explosion bead comprises a core material, a wall material and a hydrophobic modification material, the core material is wrapped inside the wall material, the core material is a mixed aqueous solution of water-soluble essence, calcium chloride and xanthan gum, the wall material is a mixture of sodium alginate and paraffin, and the hydrophobic modification material is fatty amine. The water blasting bead can successfully wrap the water-soluble essence, prolongs the storage time, enlarges the variety of the blasting bead essence and provides guarantee for the development of new blasting bead products.
CN108936802A discloses a preparation method of water-containing blasting beads for cigarettes, which is characterized in that water is pre-frozen into ice and processed into spherical ice balls; then the ice ball is placed in a plastic film groove which is processed in advance and sealed, and then the plastic film is homogenized through cutting and roller hot air processing. The prepared blasting beads can effectively add water into cigarette smoke, and improve the smoking quality of cigarettes.
Based on the research, the essence and the spice are wrapped by the water blasting beads, so that the release of the essence and the spice can be effectively controlled, and the smoking requirement of smokers is met. However, NO water-blown beads are reported to release NO and are applied to the cigarette field. Therefore, the water explosion bead is found, the release of nitric oxide is controlled, the harm of nicotine in cigarettes is reduced, and the water explosion bead has great practical significance on the body health of smokers.
Disclosure of Invention
Aiming at the defects in the prior art and the practical requirements, the invention aims to provide a water explosion bead, and a preparation method, a preparation device and application thereof. The water blasting bead wraps water or water solution, and when the water blasting bead is used, the NO release is controlled in a mode of breaking the blasting bead, so that the harm of nicotine is reduced, and the smoking mouthfeel of smokers is improved.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a water explosion bead, which comprises an inner core and a wall material;
the inner core is water or an aqueous solution, the wall material comprises a first component and a second component, the first component is palm wax, the second component is any one or combination of at least two of paraffin wax, microcrystalline wax, beeswax or polyethylene wax, the combination of at least two of paraffin wax and microcrystalline wax or the combination of microcrystalline wax and polyethylene wax can be selected, and any combination mode can be selected, so that the repeated description is omitted.
According to the invention, water or an aqueous solution is selected as an inner core of the water blasting bead, so that the isolation of the water blasting bead from a nitric oxide donor can be ensured, and the long-term preservation of the nitric oxide donor is realized; the wall material obtained by matching and using the palm wax and other waxy materials (such as paraffin wax, microcrystalline wax, beeswax or polyethylene wax) with the density lower than that of the palm wax can ensure that the texture of the water exploded bead is hard, and is favorable for realizing the long-term storage of the water exploded bead.
Preferably, the aqueous solution is an acidic aqueous solution.
Preferably, the pH of the acidic aqueous solution is 1 to 5.
The number of 1 to 5 may be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5, etc.
Other point values within the above range can be selected, and are not described in detail herein.
Preferably, the acidic aqueous solution contains an organic acid and/or an inorganic acid, preferably a combination of an organic acid and an inorganic acid.
The organic acid may be obtained by reacting a strong organic acid with a weak organic acid salt.
The inorganic acid may be obtained by reacting a strong inorganic acid with a weak inorganic acid salt.
Preferably, the organic acid comprises any one or a combination of at least two of citric acid, L-ascorbic acid, oxalic acid or acetic acid, preferably L-ascorbic acid and/or citric acid.
The combination of the at least two compounds can be a combination of citric acid and L-ascorbic acid or a combination of L-ascorbic acid and oxalic acid, and any combination mode can be selected, and is not repeated here.
Preferably, the inorganic acid comprises any one of hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid or a combination of at least two thereof, preferably hydrochloric acid and/or nitric acid.
The combination of the at least two compounds can be a combination of hydrochloric acid and sulfuric acid or a combination of sulfuric acid and nitric acid, and the like, and any combination mode can be selected, so that the details are not repeated.
Preferably, the aqueous solution is an alkaline aqueous solution.
Preferably, the pH of the basic aqueous solution is 7.5 to 13.
The number of the 7.5-13 can be 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5, 12, 12.5 or 13, etc.
Other point values within the above range can be selected, and are not described in detail herein.
Preferably, the aqueous alkaline solution contains an organic base and/or an inorganic base, preferably a combination of an organic base and an inorganic base.
Preferably, the organic base comprises any one or a combination of at least two of sodium citrate, sodium L-ascorbate, sodium oxalate, sodium acetate or chitosan, preferably sodium citrate and/or sodium L-ascorbate.
The combination of the at least two compounds can be a combination of sodium citrate and sodium L-ascorbate or a combination of sodium L-ascorbate and sodium oxalate, and the like, and any combination mode can be selected, which is not described in detail herein.
Preferably, the inorganic base comprises any one or a combination of at least two of sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, potassium carbonate, potassium bicarbonate or potassium dihydrogen phosphate, preferably sodium bicarbonate and/or sodium hydroxide.
The combination of the at least two compounds can be a combination of sodium carbonate and sodium bicarbonate or a combination of sodium bicarbonate and sodium dihydrogen phosphate, and the like, and any combination mode can be selected, so that the details are not repeated.
In the invention, the aqueous solution also contains a stabilizer, and the stabilizer comprises sodium chloride and/or potassium chloride.
The stabilizer is added to the inner core of the water blasting bead, so that the weight can be balanced, the density of the inner core of the water blasting bead is increased, the inner core of the water blasting bead can be lowered more quickly when the cooling liquid is dripped into the inner core, and the deterioration of water or an aqueous solution can be further prevented.
Preferably, the mass ratio of the first component to the second component is 1 (0.2-1.5).
The 1 (0.2-1.5) can be 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1.0, 1:1.1, 1:1.2, 1:1.3, 1:1.4 or 1:1.5, etc.
Other point values within the above range can be selected, and are not described in detail herein.
In a second aspect, the present invention provides a method for preparing the water blasting bead according to the first aspect, comprising the following steps:
and dripping water or aqueous solution into the wall material in a molten state for encapsulation, and then dripping into cooling liquid for cooling to obtain the water blasting bead.
Preferably, the water or aqueous solution is added dropwise in an amount of 20 to 110. mu.L per drop.
The 20-110 μ L may be 20 μ L, 30 μ L, 40 μ L, 50 μ L, 60 μ L, 70 μ L, 80 μ L, 90 μ L, 100 μ L or 110 μ L.
The cooling liquid comprises ice water or silicone oil.
Preferably, the wall material is melted at a temperature of 50 to 120 ℃.
The temperature of 50-120 deg.C can be 50 deg.C, 55 deg.C, 60 deg.C, 65 deg.C, 70 deg.C, 75 deg.C, 80 deg.C, 85 deg.C, 90 deg.C, 95 deg.C, 100 deg.C, 105 deg.C, 110 deg.C, 115 deg.C or 120 deg.C, etc.
Preferably, the temperature of the cooling liquid is 0-20 ℃.
The temperature of 0-20 deg.C can be 0 deg.C, 1 deg.C, 2 deg.C, 3 deg.C, 4 deg.C, 5 deg.C, 6 deg.C, 7 deg.C, 8 deg.C, 9 deg.C, 10 deg.C, 11 deg.C, 12 deg.C, 13 deg.C, 14 deg.C, 15 deg.C, 16 deg.C, 17 deg.C, 18 deg.C, 19 deg.C or 20 deg.C, etc.
Other point values within the above range can be selected, and are not described in detail herein.
In a third aspect, the present invention provides a device for preparing water-exploded beads according to the first aspect, comprising: dropping device, barrel, first temperature sensor, second temperature sensor, heater and cooler.
The dropping liquid device is located the barrel top, the dropping liquid device is used for dripping water or aqueous solution, the barrel divide into upper zone and lower region, is used for holding wall material and coolant liquid respectively.
The first temperature sensor and the second temperature sensor are vertically inserted into the cylinder body and are respectively used for monitoring the temperature of the wall material and the temperature of the cooling liquid; the heater and the cooler are arranged on the outer side of the cylinder body and are respectively used for heating the wall material and maintaining the temperature of the cooling liquid.
The invention relates to a preparation device of water blasting beads, which is characterized in that a wall material and cooling liquid are contained in a cylinder, the wall material is heated by a heater and is in a molten state, the temperature of the wall material is ensured to be 50-120 ℃ through monitoring of a first temperature sensor so as to ensure that molten wax can wrap water or aqueous solution when the water or aqueous solution in a dropping device drops, and the cooling liquid is used for cooling and solidifying the molten wax wrapped with the water or aqueous solution through maintaining the temperature to be 0-20 ℃ through a cooler under monitoring of a second temperature sensor so as to form hard water blasting beads.
In a fourth aspect, the present invention provides the use of a water-exploded bead as described in the first aspect in the preparation of a mouthpiece content.
In a fifth aspect, the present invention provides a mouthpiece content comprising a substrate and, supported on the substrate, a water bead, an additive and a nitric oxide donor.
When the water blasting bead is used, water or aqueous solution is released in a crushing mode, so that the water blasting bead reacts with a nitric oxide donor to release nitric oxide, and is matched with nicotine for use, the satisfying state of smokers on smoking is achieved, and the harm of smoking to human bodies is reduced.
It should be noted that after smoking cigarettes, the concentration of NO in the body increases sharply, and the sharply increased NO, as a free radical reservoir, can be converted into more active free radicals centered on oxygen and carbon, which can destroy the balance of oxidation and oxidation resistance in the body, accelerate the process of oxidation and peroxidation in the body, and intensify the degree of damage of oxidation and peroxidation in the body, thereby causing damage to the organ tissues of the body and affecting the health of the body. However, trace NO, as a signaling molecule of the nervous system, has functions of resisting infection and regulating blood pressure. Clinical application of NO proves that NO has the effects of treating and relieving various diseases (such as cardiovascular diseases, nervous system diseases, lung diseases, tumors and the like). Therefore, if the NO in the cigarette smoke can be reduced to a trace amount required by treatment, the harm can be changed into the benefit.
In addition, in order to achieve a smoking experience with conventional cigarettes, conventional electronic cigarette users increase the amount of nicotine that affects themselves by longer smoking times, greater smoke inhalation, and slower smoking rates. However, the NO generation system is artificially added into the electronic cigarette, so that the absorption of human bodies to nicotine is promoted, the absorption rate of nicotine is improved, the defect that NO is contained in the electronic cigarette can be overcome, the same quality and smoking experience as those of the traditional cigarette are achieved, the release amount of NO is accurately controlled, the beneficial effect of NO is fully played, and the excellent smoking cessation effect is achieved.
Preferably, the additive comprises any one of sodium bicarbonate, sodium carbonate, sodium dihydrogen phosphate, sodium chloride, potassium carbonate, potassium bicarbonate, potassium dihydrogen phosphate or potassium chloride, or a combination of at least two thereof.
The combination of the at least two compounds can be a combination of sodium bicarbonate and sodium carbonate or a combination of sodium bicarbonate and sodium dihydrogen phosphate, and the like, and any combination mode can be selected, so that the details are not repeated.
The additive can promote NO donor to release NO more rapidly and convert NO into NO2The ratio of (a) to (b) is small.
The nitric oxide donor includes any one of S-nitrosoglutathione, S-nitroso-N-acetyl-DL-penicillamine, diazeniumdiolate, inorganic nitrate or organic nitrate or a combination of at least two thereof.
The combination of the nitric oxide donor can be a combination of S-nitrosoglutathione and S-nitroso-N-acetyl-DL-penicillamine or a combination of diazeniumdiolate and inorganic nitrate, and the like, and any combination mode can be selected, so that the description is omitted.
Preferably, the ratio of the mass of the nitric oxide donor to the total volume of water or aqueous solution contained in the inner core of the water-exploded bead used is 0.05-0.6mg/μ L.
The concentration of the aforementioned 0.05-0.6 mg/. mu.L may be 0.05 mg/. mu.L, 0.1 mg/. mu.L, 0.15 mg/. mu.L, 0.2 mg/. mu.L, 0.25 mg/. mu.L, 0.3 mg/. mu.L, 0.35 mg/. mu.L, 0.4 mg/. mu.L, 0.45 mg/. mu.L, 0.5 mg/. mu.L, 0.55 mg/. mu.L, or 0.6 mg/. mu.L, etc.
The ratio of the mass of the nitric oxide donor to the volume of the solution contained in the inner core of the water-exploded bead needs to be in a suitable range to ensure a fast release of the required NO in a short time.
Preferably, the mass ratio of the additive to the nitric oxide donor is (1.5-4): 1.
The ratio of (1.5-4):1 may be 1.5:1, 1.7:1, 1.9:1, 2.0:1, 2.2:1, 2.4:1, 2.6:1, 2.8:1, 3.0, 3.2, 3.4, 3.6, 3.8 or 4:1, etc.
Other point values within the above range can be selected, and are not described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
(1) according to the invention, water or aqueous solution is placed in the water blasting bead, so that the isolation from the nitric oxide donor can be realized. Meanwhile, the mixed wax is selected as the wall material, so that the texture is hard, and the long-term storage of the water blasting beads is facilitated;
(2) the water blasting bead can be applied to preparing the content of the cigarette holder, when the water blasting bead is pinched and broken, water or aqueous solution in the water blasting bead is released, so that the water or aqueous solution reacts with the nitric oxide donor to release nitric oxide, and the nitric oxide is matched with nicotine for use, thereby achieving the satisfying state of smokers for smoking and reducing the harm of smoking to human bodies.
Drawings
FIG. 1 is a diagram of an apparatus for preparing water exploded beads according to the present invention;
wherein, 1 is the dropping liquid device, 2 is the barrel, 3 is first temperature sensor, 4 is the second temperature sensor, 5 is the heater, 6 is the cooler.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The structure of the preparation device of the water explosion bead is shown in figure 1. The preparation facilities of water explodes pearl includes: dropping liquid device 1, barrel 2, first temperature sensor 3, second temperature sensor 4, heater 5 and cooler 6, dropping liquid device 1 is used for dripping water or aqueous solution, barrel 2 divide into upper zone and lower region, is used for holding wall material and coolant liquid respectively, barrel 2 is the cylinder, highly is 20cm, and the diameter is 25 mm.
Wherein, dropping liquid device 1 is located barrel 2 top, first temperature sensor 3 and the vertical barrel of inserting of second temperature sensor 4 are used for monitoring wall material temperature and coolant liquid temperature respectively, heater 5 and cooler 6 set up in the barrel 2 outside, are used for heating the wall material respectively and maintain the coolant liquid temperature.
The following examples are presented as follows:
wherein the palm wax is obtained from Shanghai leaf Biotech limited; paraffin wax was purchased from century botai chemical limited; the microcrystalline wax is purchased from Hengjing chemical Co., Ltd of Hubei; beeswax was purchased from Shenzhen Antai Biotech, Inc.; polyethylene wax was purchased from Shanyi plastication Co., Ltd, Dongguan; silicone oils were purchased from dow corning ltd. The remaining materials and starting materials are not specifically described and are commercially available from other sources.
Example 1
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 20g L-ascorbic acid and 10g sodium chloride, dissolving in 50mL water, diluting to 100mL volume to obtain aqueous solution with pH of 2.1, and storing at 0 deg.C;
(2) sequentially putting 5mL of silicone oil and 1g of wall material into a cylinder, and heating the wall material at 60 ℃ to keep the wall material in a molten state;
the wall material is palm wax and paraffin wax, the mass ratio of the palm wax to the paraffin wax is 1:0.4, and the silicone oil is maintained at 20 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 25 mu L) to obtain the water blasting bead.
Example 2
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) preparing 100mL of 0.1mol/L diluted hydrochloric acid to obtain an aqueous solution with the pH of 1.1, and storing at 5 ℃;
(2) putting 5mL of ice water and 1g of wall material into a cylinder in sequence, and heating the wall material at 70 ℃ to keep the wall material in a molten state;
the wall material is palm wax and paraffin wax, the mass ratio of the palm wax to the paraffin wax is 1:0.55, and the temperature of the ice water is maintained at 2 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 40 mu L) to obtain the water blasting bead.
Example 3
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 4g of citric acid and 5g of sodium chloride, dissolving in 60mL of water, adding 1.06mL of concentrated nitric acid (16mol/L), then diluting to 100mL to obtain an aqueous solution with pH of 5, and storing at 10 ℃;
(2) sequentially putting 5mL of silicone oil and 1g of wall material into a cylinder, and heating the wall material at 75 ℃ to keep the wall material in a molten state;
the wall material is composed of palm wax and beeswax, the mass ratio of the palm wax to the beeswax is 1:0.7, and the silicone oil is kept at 5 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 50 mu L) to obtain the water blasting bead.
Example 4
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 0.4g of sodium hydroxide and 15g of sodium chloride, dissolving in 60mL of water, diluting to 100mL to obtain an aqueous solution with pH of 13, and storing at 15 ℃;
(2) putting 5mL of ice water and 1g of wall material into a cylinder in sequence, and heating the wall material at 85 ℃ to keep the wall material in a molten state;
the wall material is composed of palm wax and beeswax, the mass ratio of the palm wax to the beeswax is 1:0.85, and the ice water is kept at 0 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 65 mu L) to obtain the water blasting beads.
Example 5
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 10g L-sodium ascorbate and 5g sodium chloride, dissolving in 60mL water, diluting to 100mL volume to obtain water solution with pH of 7.7, and storing at 20 deg.C;
(2) sequentially putting 5mL of silicone oil and 1g of wall material into a cylinder, and heating the wall material at 80 ℃ to keep the wall material in a molten state;
the wall material is palm wax and microcrystalline wax, the mass ratio of the palm wax to the microcrystalline wax is 1:1, and the silicone oil is maintained at 10 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 80 mu L) to obtain the water blasting bead.
Example 6
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 7.5g of sodium citrate, 7.5g of sodium bicarbonate and 5g of potassium chloride, dissolving in 60mL of water, diluting to 100mL to obtain an aqueous solution with the pH value of 8.1, and storing at 15 ℃;
(2) putting 5mL of ice water and 1g of wall material into a cylinder in sequence, and heating the wall material at 100 ℃ to keep the wall material in a molten state;
the wall material is palm wax and microcrystalline wax, the mass ratio of the palm wax to the microcrystalline wax is 1:1.25, and the temperature of the ice water is maintained at 5 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 90 mu L) to obtain the water blasting bead.
Example 7
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) weighing 12.5g of citric acid, 12.5g L-sodium ascorbate and 10g of sodium chloride, dissolving in 70mL of water, diluting to 100mL to obtain an aqueous solution with pH of 3.3, and storing at 10 ℃;
(2) putting 5mL of silicone oil and 1g of wall material into a cylinder in sequence, and heating the wall material at 110 ℃ to keep the wall material in a molten state;
the wall material is palm wax and polyethylene wax, the mass ratio of the palm wax to the polyethylene wax is 1:1.5, and the silicone oil is maintained at 15 ℃ through a cooler;
(3) and (3) sucking the aqueous solution obtained in the step (1) by using a liquid transfer gun, and dropwise adding the aqueous solution into the cylinder containing the wall material and the cooling liquid in the step (2) (the dropwise adding amount of each drop is 105 mu L) to obtain the water blasting bead.
Example 8
The embodiment provides a water blasting bead and a preparation method thereof, wherein the preparation method comprises the following steps:
(1) sequentially putting 5mL of silicone oil and 1g of wall material into a cylinder, and heating the wall material at 60 ℃ to keep the wall material in a molten state;
the wall material is palm wax and paraffin wax, the mass ratio of the palm wax to the paraffin wax is 1:0.4, and the silicone oil is kept at 15 ℃ through a cooler;
(2) and (3) sucking deionized water by using a liquid transfer gun, and dropwise adding the deionized water into the cylinder containing the wall material and the cooling liquid in the step (2) (the addition amount of each drop is 25 mu L) to obtain the water blasting beads.
Example 9
This example provides a water exploded bead and a method for preparing the same, which differs from example 1 only in that the L-ascorbic acid is replaced with oxalic acid in equal amounts to give an aqueous solution with a pH of 1.9, and the remaining parameters are in accordance with example 1. The preparation process is referred to example 1.
Example 10
This example provides a water exploded bead and a method for preparing the same, differing from example 1 only in that the L-ascorbic acid was replaced equally with sodium acetate to give an aqueous solution having a pH of 8.5, the remaining parameters remaining in accordance with example 1. The preparation process is referred to example 1.
Comparative example 1
This comparative example provides a water exploded bead and a method of making the same, differing from example 1 only in that the wall material is a single carnauba wax, the remaining parameters remaining consistent with example 1. The preparation process is referred to example 1.
As a result, it was found that molded water-exploded beads could not be obtained by using only palm wax as the wall material.
Comparative example 2
This comparative example provides a water exploded bead and a method for preparing the same, which is different from example 1 only in that the wall material is a single paraffin wax and the remaining parameters are consistent with example 1. The preparation process is referred to example 1.
As a result, it was found that a single paraffin wax was used as the wall material, and a formed water-blown bead could be obtained, but the wall of the water-blown bead was very thin, and thus it was not practical.
Application example 1
The application example provides a cigarette holder content, which comprises two layers of filter cotton, wherein 2 water exploded beads prepared in example 1, 0.048g of sodium bicarbonate and 0.015g of 0.015g s-nitrosoglutathione are contained between the two layers of filter cotton.
Application example 2
The application example provides a cigarette holder content, which comprises two layers of filter cotton, wherein 1 water blasting bead prepared in the embodiment 2, 0.040g of sodium chloride and 0.020g of sodium nitrite are contained between the two layers of filter cotton.
Application example 3
The application example provides a cigarette holder content, which comprises two layers of filter cotton, wherein 1 water blasting bead prepared in the embodiment 3, 0.030g of potassium chloride and 0.010g of potassium nitrite are contained between the two layers of filter cotton.
Application example 4
The application example provides a cigarette holder content, which comprises two layers of filter cotton, wherein 1 water blasting bead prepared in example 4, 0.045g of sodium carbonate and 0.030g s-nitrosoglutathione are contained between the two layers of filter cotton.
Application example 5
This application provides a mouthpiece content comprising two layers of filter cotton containing between them 1 water popple made according to example 5, 0.020g sodium carbonate and 0.005g S-nitroso-N-acetyl-DL-penicillamine.
Application example 6
This application provides a mouthpiece content comprising two layers of filter cotton containing between them 1 water popple of example 6, 0.050g sodium chloride and 0.025g S-nitroso-N-acetyl-DL-penicillamine.
Application example 7
This application example provides a mouthpiece content comprising two layers of filter pulp, between which 1 water bead of example 7, 0.030g potassium chloride and 0.010g diazeniumdiolate are contained.
Application examples 8 to 10
The present application examples 8-10 provide 3 mouthpiece contents, differing from application example 1 only in that the water blown beads produced in example 1 were replaced equally with the water blown beads produced in examples 8-10, with the remaining parameters being in accordance with application example 1.
Application example 11
The present application example provided 1 kinds of mouthpiece contents, and the difference from application example 1 was only that the mass of s-nitrosoglutathione was 0.040g, and the remaining parameters were consistent with application example 1.
Application example 12
This application example provides 1 mouthpiece content comprising two layers of filter cotton containing 3 water blown beads of example 1, 0.003g sodium bicarbonate and 0.001g s-nitrosoglutathione between the two layers of filter cotton.
Application example 13
The present application example provided 1 types of mouthpiece contents, differing from application example 1 only in that the mass of sodium bicarbonate was 0.015g, and the remaining parameters were consistent with application example 1.
Comparative application example 1
This comparative application example provides a mouthpiece content that differs from application example 1 only in that the electronic cigarette mouthpiece content does not include sodium bicarbonate, with the remaining parameters being consistent with application example 1.
Test example 1
This test example tests the diameter and the liquid loading of the water exploding beads obtained in examples 1 to 10. The test method is as follows:
and (3) diameter testing: respectively and randomly selecting 20 water blasting beads prepared in the embodiments 1 to 10, measuring the diameter of each blasting bead by using a vernier caliper, and averaging the measured data;
and (3) liquid carrying amount testing: 20 beads of the water-exploded beads obtained in examples 1 to 10 were randomly selected, respectively, put into a 10mL centrifuge tube, weighed on a precision balance and recorded as m1(mg), then, the beads were extruded and exploded using tweezers, dried in an oven at 60 ℃ after extrusion and taken out and weighed every 5min until the weight no longer changed, and recorded as m2 (mg). And obtaining the average liquid carrying capacity of the water blasting beads.
The average liquid carrying capacity of the water blasting beads is calculated according to the following formula:
the average liquid loading capacity is (m1-m 2)/20.
The statistics of the test results are shown in table 1 below:
TABLE 1
As can be seen from the data in the table, the diameter of the water explosion bead provided by the invention can fluctuate between 0.86 and 6.70mm, and the liquid carrying capacity of the water explosion bead provided by the invention can fluctuate between 20.7 and 102.5 mg. It can be seen that the water blasting bead has wide diameter range, wide liquid carrying amount range and strong applicability.
Test example 2
The test examples performed NO release process tests on the contents of the mouthpieces prepared in application examples 1 to 13 and comparative application example 1. The test method is as follows:
and (3) putting the blasting beads, a nitric oxide donor, an additive and the like into a tool, adding a nitrogen oxide analyzer, and detecting the concentration of NO. In addition, a blank control group (without adding water to explode beads) is arranged, the nitric oxide donor and the additive are placed in a tool, a nitrogen oxide analyzer is added, and the concentration of NO is detected.
The statistics of the test results are shown in table 2 below:
TABLE 2
As can be seen from the data in the table, the water blasting bead provided by the invention can effectively control the release of NO. As can be seen from the data of application example 8: when the inner core of the water blasting bead is water, the release amount of NO is low. From the data of application examples 9 to 10, it can be seen that: when the inner core of the water blasting bead is aqueous solution, the selection of the solute can influence the release of NO. From the data of application examples 11 to 12, it can be seen that: the release of NO is affected when the ratio of the mass of the nitric oxide donor to the total volume of the solution contained in the inner core of the water-exploded bead used is not between 0.05 and 0.6mg/μ L. From the data of application example 13, it can be seen that: when the amount of sodium bicarbonate added is too low, it may have a slight influence on the release of NO. From the data of comparative application example 1, it can be seen that: when NO sodium bicarbonate is added, the release of NO is affected. The method has the advantages that the span of the release amount of NO is large, the applicable range is wide, and the requirements for different NO release amounts can be met, so that the method is better applied to electronic cigarettes or cigarettes, the harm of smoking to human bodies is reduced, and the smoking cessation effect is better achieved.
Test example 3
In this test example, the contents of the cigarette holders prepared in application examples 1 to 13 and comparative application example 1 were applied to cigarettes or electronic cigarettes, and the contents were subjected to a human body smoking test in cooperation with nicotine. The test method is as follows:
grouping: 160 volunteer subjects were selected and divided into 16 groups, of which 1-14 groups were smoked with cigarettes or electronic cigarettes containing application examples 1-13 and comparative application example 1 as the mouthpiece content, 15 groups were control group 1 (nicotine alone), 16 groups were control group 2 (water exploded beads alone and NO donor alone), and 10 persons were each group;
and (3) testing: the subjects smoke and score the upper feelings of smoking according to the self (the fraction is an integer n, n is more than or equal to 1 and less than or equal to 10). The scoring criteria are shown in table 3 below:
TABLE 3
| Feel and taste of the head | Score value |
| Without feeling of putting |
1≤n＜3 |
| Slight feeling of putting head on | 3≤n＜6 |
| Strong feeling of putting |
6≤n≤8 |
| Strong feeling of putting head | 8＜n≤10 |
The test results are shown statistically in table 4 below (scores are the average of scores of 10 subjects per group, respectively):
TABLE 4
| Group of | Score value |
| Application example 1 | 9.1 |
| Application example 2 | 9.2 |
| Application example 3 | 9.3 |
| Application example 4 | 9.4 |
| Application example 5 | 7.9 |
| Application example 6 | 9.3 |
| Application example 7 | 7.4 |
| Application example 8 | 3.8 |
| Application example 9 | 3.6 |
| Application example 10 | 3.5 |
| Application example 11 | 9.0 |
| Application example 12 | 3.7 |
| Application example 13 | 8.9 |
| Comparative application example 1 | 4.1 |
| |
2.1 |
| |
1.8 |
As can be seen from the data in the above table, the inhalation of a certain amount of NO gas together with nicotine can increase the feeling of the upper part of the cigarette; while pure water pops the beads and NO donor or nicotine alone do not substantially increase the feeling of the head.
In summary, the present invention can achieve isolation from the nitric oxide donor by placing water or an aqueous solution in the water blasting bead. Meanwhile, the mixed wax is selected as the wall material, so that the texture is hard, and the long-term storage of the water blasting beads is favorably realized. The water blasting bead can be applied to preparing the content of the cigarette holder, when the water blasting bead is pinched and broken, water or aqueous solution in the water blasting bead is released, so that the water or aqueous solution reacts with the nitric oxide donor to release nitric oxide, and the nitric oxide is matched with nicotine for use, thereby achieving the satisfying state of smokers for smoking and reducing the harm of smoking to human bodies.
The applicant declares that the above description is only a specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and it should be understood by those skilled in the art that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are within the scope and disclosure of the present invention.
Claims (10)
1. The water explosion bead is characterized by comprising an inner core and a wall material;
the inner core is water or an aqueous solution, the wall material comprises a first component and a second component, the first component is palm wax, and the second component is any one or a combination of at least two of paraffin wax, microcrystalline wax, beeswax or polyethylene wax.
2. The water-exploded bead according to claim 1, wherein said aqueous solution is an acidic aqueous solution;
preferably, the pH of the acidic aqueous solution is 1-5;
preferably, the acidic aqueous solution contains an organic acid and/or an inorganic acid, preferably a combination of an organic acid and an inorganic acid;
preferably, the organic acid comprises any one or a combination of at least two of citric acid, L-ascorbic acid, oxalic acid or acetic acid, preferably L-ascorbic acid and/or citric acid;
preferably, the inorganic acid comprises any one of hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid or a combination of at least two thereof, preferably hydrochloric acid and/or nitric acid.
3. The water-exploded bead according to claim 1 or 2, wherein the aqueous solution is an alkaline aqueous solution;
preferably, the pH of the basic aqueous solution is 7.5-13;
preferably, the alkaline aqueous solution contains an organic base and/or an inorganic base, preferably a combination of the organic base and the inorganic base;
preferably, the organic base comprises any one or combination of at least two of sodium citrate, sodium L-ascorbate, sodium oxalate, sodium acetate or chitosan, preferably sodium citrate and/or sodium L-ascorbate;
preferably, the inorganic base comprises any one or a combination of at least two of sodium carbonate, sodium hydroxide, sodium bicarbonate, sodium dihydrogen phosphate, potassium carbonate, potassium bicarbonate or potassium dihydrogen phosphate, preferably sodium bicarbonate and/or sodium hydroxide.
4. The water explosion bead according to any one of claims 1 to 3, wherein the aqueous solution further comprises a stabilizer, and the stabilizer comprises sodium chloride and/or potassium chloride.
5. The water explosion bead as claimed in any one of claims 1 to 4, wherein the mass ratio of the first component to the second component is 1 (0.2 to 1.5).
6. A method of producing water-exploded beads according to any one of claims 1 to 5, comprising the steps of:
dripping water or water solution into the wall material in a molten state for encapsulation, and then dripping into cooling liquid for cooling to obtain the water blasting bead;
preferably, the water or the aqueous solution is dripped in a dripping amount of 20-110 mu L per droplet;
preferably, the cooling liquid comprises ice water or silicone oil;
preferably, the wall material is melted at a temperature of 50-120 ℃;
preferably, the temperature of the cooling liquid is 0-20 ℃.
7. A preparation apparatus for preparing the water-exploded bead of any one of claims 1 to 5, wherein the preparation apparatus comprises: the device comprises a liquid dropping device, a cylinder, a first temperature sensor, a second temperature sensor, a heater and a cooler;
the liquid dropping device is positioned above the cylinder and is used for dropping water or aqueous solution, and the cylinder is divided into an upper area and a lower area which are respectively used for containing wall materials and cooling liquid;
the first temperature sensor and the second temperature sensor are vertically inserted into the cylinder body and are respectively used for monitoring the temperature of the wall material and the temperature of the cooling liquid; the heater and the cooler are arranged on the outer side of the cylinder body and are respectively used for heating the wall material and maintaining the temperature of the cooling liquid.
8. Use of a water-exploded bead according to any one of claims 1 to 5 for the preparation of a mouthpiece content.
9. A mouthpiece content, characterized in that the mouthpiece content comprises a substrate and the water blasting bead, additive and nitric oxide donor of any of claims 1-5 supported on the substrate.
10. A mouthpiece content according to claim 9, wherein the additive comprises any one of sodium bicarbonate, sodium carbonate, sodium dihydrogen phosphate, sodium chloride, potassium carbonate, potassium bicarbonate, potassium dihydrogen phosphate or potassium chloride, or a combination of at least two thereof;
preferably, the nitric oxide donor comprises any one of, or a combination of at least two of, S-nitrosoglutathione, S-nitroso-N-acetyl-DL-penicillamine, diazeniumdiolate, inorganic nitrate or organic nitrate;
preferably, the ratio of the mass of the nitric oxide donor to the total volume of water or aqueous solution contained in the inner core of the water-exploded bead used is 0.05-0.6mg/μ L;
preferably, the mass ratio of the additive to the nitric oxide donor is (1.5-4): 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111654097.4A CN114287668B (en) | 2021-12-30 | 2021-12-30 | Water explosion bead and preparation method, preparation device and application thereof |
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| CN202111654097.4A CN114287668B (en) | 2021-12-30 | 2021-12-30 | Water explosion bead and preparation method, preparation device and application thereof |
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