CN114275249A - Preparation equipment of powder for injection - Google Patents
Preparation equipment of powder for injection Download PDFInfo
- Publication number
- CN114275249A CN114275249A CN202111621525.3A CN202111621525A CN114275249A CN 114275249 A CN114275249 A CN 114275249A CN 202111621525 A CN202111621525 A CN 202111621525A CN 114275249 A CN114275249 A CN 114275249A
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- Prior art keywords
- freeze
- drying box
- plate
- sliding
- groove
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- 238000002347 injection Methods 0.000 title claims abstract description 32
- 239000007924 injection Substances 0.000 title claims abstract description 32
- 239000000843 powder Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000004108 freeze drying Methods 0.000 claims abstract description 119
- 229930182555 Penicillin Natural products 0.000 claims abstract description 101
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 101
- 229940049954 penicillin Drugs 0.000 claims abstract description 101
- 239000003814 drug Substances 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 229910000831 Steel Inorganic materials 0.000 claims description 33
- 239000010959 steel Substances 0.000 claims description 33
- 238000007789 sealing Methods 0.000 claims description 21
- 241001411320 Eriogonum inflatum Species 0.000 claims description 16
- 230000033001 locomotion Effects 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000011261 inert gas Substances 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 230000000712 assembly Effects 0.000 claims 2
- 238000000429 assembly Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The invention discloses preparation equipment of powder for injection, which comprises penicillin bottles filled with liquid medicine, wherein a cover placing unit and a freeze-drying unit are sequentially arranged on one side of a conveyor belt along the conveying direction of the conveyor belt, a cover plate is arranged on the cover placing unit and corresponds to bottle openings of a plurality of penicillin bottles, a freeze-drying box is arranged on a lifting hydraulic cylinder and is provided with an opening, a door plate capable of closing the opening is arranged on the freeze-drying box, a pushing assembly is arranged on the other side of the conveyor belt and can push a penicillin bottle group into the freeze-drying box, and a cover taking assembly capable of taking off the cover plate is arranged in the freeze-drying box. This application carries out interim sealed with xiLin bottle through the apron, when getting into freeze-drying incasement, takes off through getting the lid subassembly, need not be to xiLin bottle plug rubber buffer, because cold and hot alternation influences the freeze-drying quality of powder injection when having avoided the rubber buffer freeze-drying.
Description
Technical Field
The invention relates to the field of powder injection preparation, in particular to a preparation device of powder for injection.
Background
The powder injection is a powdery object formed by mixing the medicine and the reagent and then sterilizing and drying, so that the powder injection is convenient to transport and store. The powder injection is diluted with glucose solution for injection, and the injection can be diluted for direct injection according to different dosage. The powder injection is prepared by a freeze drying technology. In the existing preparation device for the powder injection, after the penicillin bottle is filled, the penicillin bottle is half-plugged through the rubber plug, so that the liquid medicine in the penicillin bottle is ensured not to be polluted, but impurities possibly enter the penicillin bottle through the half-plugged rubber plug because the rubber plug is in a half-plugged state; according to the existing preparation device for the powder injection, a penicillin bottle and a rubber plug are simultaneously placed into a freeze-drying box for freeze-drying, and the quality of the powder injection in the penicillin bottle can be possibly influenced by the cold and hot alternation in the freeze-drying box.
Disclosure of Invention
The invention aims to provide a preparation device of powder for injection, which is used for preparing powder injection.
The aim of the invention is realized by the technical scheme that the device comprises a movable cover placing unit, a freeze-drying unit for freeze-drying the medicament in the penicillin bottle and a conveyor belt;
the penicillin bottles filled with the liquid medicine are placed on the conveying belt, a cover placing unit and a freeze-drying unit are sequentially arranged on one side of the conveying belt along the conveying direction of the conveying belt, a cover plate is arranged on the cover placing unit and corresponds to bottle openings of the plurality of penicillin bottles, and the plurality of penicillin bottles with the same cover plate are penicillin bottle groups;
the freeze-drying unit comprises a door plate, a freeze-drying box, a pushing assembly and a cover taking assembly;
the freeze-drying case sets up in conveyer belt one side, the freeze-drying case is located conveyer belt direction of transfer's the place ahead, the freeze-drying case sets up on hydraulic cylinder, hydraulic cylinder's lifting direction and conveyer belt up end are mutually perpendicular, the freeze-drying case is close to conveyer belt one side and has seted up the opening, rotate on the freeze-drying case and be provided with the door plant that can close the opening, the conveyer belt be provided with the propelling movement subassembly for the opposite side of freeze-drying case, the propelling movement end of propelling movement subassembly can pass the opening and stretch into in the freeze-drying case, the propelling movement starting point position of the propelling movement end of propelling movement subassembly corresponds with xiLin bottle group on the conveyer belt, the propelling movement terminal point position of propelling movement end of propelling movement subassembly corresponds with in the freeze-drying case, be provided with the lid subassembly of getting on the removable xiLin bottle group in the freeze-drying case.
Preferably, the cover placing unit comprises a mechanical arm, a sucker and a water pool;
the automatic penicillin bottle group machine is characterized in that a cover plate is arranged in the water pool, the mechanical arm is arranged on one side of the conveying belt and located behind the conveying direction of the conveying belt, a sucker is arranged on the mechanical arm and can correspond to the upper end face of the cover plate, the motion starting point position of the mechanical arm corresponds to the position in the water pool, and the motion end point position of the mechanical arm corresponds to the bottle mouth of the penicillin bottle group.
Preferably, still be provided with a plurality of baffles that are parallel to each other in the freeze-drying case, the baffle parallels with the bottom plate of freeze-drying case, and a plurality of the baffle is divided into a plurality of cavities with the freeze-drying case, and a plurality of the interior roof of cavity all is provided with gets the lid subassembly, it is corresponding with the apron on a plurality of xiLin bottle group in the cavity to get the lid subassembly, xiLin bottle group can be placed to the diapire of cavity.
Preferably, the pushing assembly comprises an air cylinder, a pushing plate and a guide plate;
the cylinder is arranged on one side of the conveyor belt far away from the freeze-drying box, a push plate is arranged between the cylinder and the penicillin bottle group and arranged on a telescopic rod of the cylinder, the side wall, close to the conveyor belt, of the push plate corresponds to the penicillin bottle group, the telescopic direction of the cylinder is perpendicular to the front wall, close to the opening, of the freeze-drying box, the moving starting point position of the push plate corresponds to the penicillin bottle group on the conveyor belt, and the moving end point position of the push plate corresponds to the inside of the cavity;
the penicillin bottle group placing device is characterized in that a guide plate is arranged between the conveyor belt and the freeze-drying box, the upper end face of the guide plate is parallel and level to the upper end face of the conveyor belt, a penicillin bottle group can be placed on the upper end face of the guide plate, the gap between the guide plate and the conveyor belt is smaller than the diameter of a penicillin bottle, and the gap between the guide plate and the freeze-drying box is smaller than the diameter of the penicillin bottle.
Preferably, the cap taking assembly comprises a plurality of cap taking modules, a support module and a power module, the cap taking modules are rotatably arranged in the cavity and can correspond to cover plates on penicillin bottle groups in the cavity, the cover plates are made of stainless steel, the power module comprises a rotating end and a lifting end, the rotating end of the power module can drive the cap taking modules to rotate, and the lifting end of the power module can drive the cap taking modules to lift;
the cover taking module comprises a support frame, the support frame is positioned above the penicillin bottle group, the upper end face of the support frame is attached to the lower end face of the cavity, a plurality of locking sub-modules used for locking the cover plate on the lower end face of the support frame are arranged on the side wall of the support frame, the upper end face of the cover plate can be attached to the lower end face of the support frame, and a closed cavity can be formed among the cover plate, the support frame and the lower end face of the cavity;
a rotating shaft is arranged between the supporting frame and the left side wall of the cavity, the axis of the rotating shaft is parallel to the line of the circle center of each penicillin bottle of the penicillin bottle group, one end of the rotating shaft is connected to the supporting frame, the other end of the rotating shaft can rotatably penetrate through the first sealing sliding submodule and extend out of the freeze-drying box, the first sealing sliding submodule can be arranged on the side wall of the freeze-drying box in a lifting mode, a sleeve is sleeved on the extending section of the freeze-drying box of the rotating shaft, the sleeve is arranged on the supporting module, the supporting module is arranged on the lifting end of the power module, chain discs are further arranged on the extending section of the freeze-drying box of the rotating shaft, a plurality of chain discs of the cover taking module are connected and driven through chains, and the chain discs are connected with the rotating end of the power module;
a first steel pipe is arranged between the supporting frame and the right side wall of the cavity, the axis of the first steel pipe is coincident with the axis of the axis, one end of the first steel pipe penetrates through the side wall of the supporting frame and is communicated with the closed cavity, the other end of the first steel pipe rotatably penetrates through the second sealing sliding sub-module and extends out of the freeze-drying box, the second sealing sliding sub-module is arranged on the side wall of the freeze-drying box in a lifting mode, and the extending section of the freeze-drying box of the first steel pipe is communicated with a vacuum system through an air pipe;
the supporting frame is also provided with a second steel pipe, and the second steel pipe penetrates through the side wall of the supporting frame and is communicated with the cavity and the sealing cavity;
a one-way valve for controlling gas to flow from the cavity to the sealing cavity is arranged in the second steel pipe;
a first clamping submodule and a second clamping submodule are arranged in the supporting frame, a plurality of penicillin bottle stoppers are clamped between the first clamping submodule and the second clamping submodule, and the penicillin bottle stoppers correspond to bottle openings of penicillin bottles;
the penicillin bottle stopper comprises a stopper handle and a stopper body, wherein the stopper body corresponds to the bottle opening of the penicillin bottle, and when the penicillin bottle group is not placed in the cavity, the stopper handle is positioned above the stopper body.
Preferably, the locking sub-modules comprise lock catches, first sliding rods and first springs;
the utility model discloses a lock cover plate, including first slide bar, first spout, first slide bar, first spring, first slide bar, second slide bar, first slide bar, second slide bar, and second slide bar, and second slide bar, and second.
Preferably, the first sealing sliding submodule and the second sealing sliding submodule both comprise a through groove, a first groove, a second groove and a sliding plate;
the side wall of the freeze-drying box is provided with a through groove penetrating through the inner wall and the outer wall of the freeze-drying box, the upper end face of the through groove is provided with a first groove, the lower end face of the through groove is provided with a second groove with the same cross section as the first groove, the first groove is positioned right above the second groove, the sliding plate can slide along the first groove and the second groove, and the sliding direction of the sliding plate is vertical to the bottom end face of the freeze-drying box;
the rotating shaft can rotatably penetrate through the sliding plate of the first sealed sliding sub-module, and the first steel pipe can rotatably penetrate through the sliding plate of the second sealed sliding sub-module;
when the upper end face of the supporting frame is attached to the lower end face of the cavity, the distance between the upper end face of the sliding plate and the rotating shaft is a, the distance between the lower end face of the first sliding block and the rotating shaft is b, the distance between the upper end face of the through groove and the lower end face of the through groove is c, and a is larger than c, and b is larger than c.
Preferably, the first clamping submodule and the second clamping submodule both comprise a clamping plate, a second sliding rod and a second spring;
a second sliding rod is arranged between the clamping plate and the side wall of the supporting frame, the second sliding rod is arranged in a second sliding groove in a sliding mode, the second sliding groove is formed in the inner wall of the supporting frame, the sliding direction of the second sliding rod is perpendicular to the axis of the rotating shaft, a second spring is arranged in the second sliding groove, and the second sliding rod is connected with the second sliding groove through the second spring;
and a plurality of stopper handles of the penicillin bottle stopper are clamped between the clamping block of the first clamping submodule and the clamping block of the second clamping submodule.
Preferably, the support module comprises a support plate, the support plate is connected with a plurality of sleeves, and the support plate is arranged on the lifting end of the power module.
Preferably, the power module comprises a motor and an electric telescopic rod;
the motor is connected to the supporting plate through a motor base, and an output shaft of the motor is connected with a chain disc;
the electric telescopic rod is arranged on the bottom plate, the freeze-drying box is further arranged on the bottom plate, the bottom plate is arranged on the lifting hydraulic cylinder, the telescopic direction of the electric telescopic rod is parallel to the sliding direction of the sliding plate, the telescopic end of the electric telescopic rod is connected with the motor base, the inert gas generator is further arranged on the bottom plate, and the outlet of the inert gas generator is communicated with the interior of the freeze-drying box through the outlet pipe.
After adopting the structure, compared with the prior art, the invention has the following advantages:
1. the cover plate is arranged to seal the filled penicillin bottle, and the cover plate is taken out from the water tank, so that the penicillin bottle can be temporarily sealed, and the quality of the liquid medicine in the penicillin bottle is guaranteed;
2. the support frame and the lock catch are arranged, so that the cover plate can be locked on the lower end face of the support frame, and the penicillin bottle stopper in the sealing cavity can be ensured not to volatilize substances when the temperature is lowered and raised in the freeze-drying box, so that the quality of the powder injection in the penicillin bottle is influenced;
3. this application is through the stopper of grip block centre gripping xiLin bottle plug in the carriage, when hasp locking apron, can guarantee that the terminal surface of all stopper are located the coplanar, guarantees xiLin bottle plug to xiLin bottle's closing quality.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof.
Drawings
The drawings of the present invention are described below.
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is an enlarged view of a portion of the present invention at A;
FIG. 3 is a schematic structural diagram of the cover unit of the present invention;
FIG. 4 is a schematic structural diagram of a penicillin bottle group and a cover plate according to the present invention;
FIG. 5 is a top view of the present invention;
FIG. 6 is a cross-sectional view taken at B-B of the present invention;
FIG. 7 is a cross-sectional view at D of the present invention;
FIG. 8 is a cross-sectional view at C-C of the present invention;
FIG. 9 is an enlarged view of a portion of the present invention at E;
fig. 10 is a schematic structural view of the support frame, the cover plate, the first steel tube, the second steel tube and the penicillin bottle stopper of the present invention.
In the figure: 1. penicillin bottles; 2. a conveyor belt; 3. a cover plate; 4. a door panel; 5. freeze-drying box; 6. a lifting hydraulic cylinder; 7. an opening; 8. a penicillin bottle group; 9. a manipulator; 10. a suction cup; 11. a pool; 12. a partition plate; 13. a chamber; 14. a cylinder; 15. a push plate; 16. a guide plate; 17. a support frame; 18. a closed cavity; 19. a rotating shaft; 20. a sleeve; 21. a chain plate; 22. a chain; 23. a first steel pipe; 24. a second steel pipe; 25. a one-way valve; 26. a penicillin bottle stopper; 27. a stopper handle; 28. a plug body; 29. locking; 30. a first slide bar; 31. a first spring; 32. a through groove; 33. a first groove; 34. a second groove; 35. a sliding plate; 36. a clamping plate; 37. a second slide bar; 38. a second spring; 39. a support plate; 40. a motor; 41. an electric telescopic rod; 42. a base plate; 43. a first chute; 44. a second chute; 45. a guide slope.
Detailed Description
The invention is further illustrated by the following figures and examples.
As shown in fig. 1 to 10, a preparation apparatus for powder for injection comprises a movable capping unit, a lyophilization unit for lyophilizing a drug in a vial 1, and a conveyor 2;
the penicillin bottles 1 filled with the liquid medicine are placed on the conveyor belt 2, a cover placing unit and a freeze-drying unit are sequentially arranged on one side of the conveyor belt 2 along the conveying direction of the conveyor belt 2, a cover plate 3 is arranged on the cover placing unit, the cover plate 3 corresponds to the bottle openings of a plurality of penicillin bottles 1, and the plurality of penicillin bottles 1 placed with the same cover plate 3 are penicillin bottle groups 8;
the freeze-drying unit comprises a door plate 4, a freeze-drying box 5, a pushing assembly and a cover taking assembly;
the freeze-drying box 5 is arranged on one side of the conveyor belt 2, the freeze-drying box 5 is positioned in front of the conveying direction of the conveyor belt 2, the freeze-drying box 5 is arranged on a lifting hydraulic cylinder 6, the lifting direction of the lifting hydraulic cylinder 6 is vertical to the upper end surface of the conveyor belt 2, an opening 7 is arranged on one side of the freeze-drying box 5 close to the conveyor belt 2, a door panel 4 capable of closing the opening 7 is rotatably arranged on the freeze-drying box 5, the conveyor belt 2 is provided, on the opposite side with respect to the lyophilization chamber 5, with a pushing assembly, the pushing end of which can project through the opening 7 into the lyophilization chamber 5, the pushing starting point position of the pushing end of the pushing component corresponds to the penicillin bottle group 8 on the conveyor belt 2, the pushing end point position of the pushing end of the pushing component corresponds to the interior of the freeze-drying box 5, and a cover component of the cover plate 3 on the detachable penicillin bottle group 8 is arranged in the freeze-drying box 5.
The cover placing unit comprises a mechanical arm 9, a suction cup 10 and a water pool 11;
the automatic penicillin bottle group is characterized in that a cover plate 3 is arranged in the water pool 11, the manipulator 9 is arranged on one side of the conveyor belt 2 and located behind the conveyor belt 2 in the conveying direction, a sucker 10 is arranged on the manipulator 9, the sucker 10 can correspond to the upper end face of the cover plate 3, the movement starting point position of the manipulator 9 corresponds to the water pool 11, and the movement end point position of the manipulator 9 corresponds to the bottle mouth of the penicillin bottle group 8.
Still be provided with a plurality of baffles 12 that are parallel to each other in the freeze-drying case 5, baffle 12 parallels with the bottom plate 42 of freeze-drying case 5, and is a plurality of baffle 12 cuts apart freeze-drying case 5 into a plurality of cavities 13, and is a plurality of the interior roof of cavity 13 all is provided with gets the lid subassembly, it is corresponding with apron 3 on a plurality of xiLin bottle group 8 in the cavity 13 to get the lid subassembly, xiLin bottle group 8 can be placed to the diapire of cavity 13.
The pushing assembly comprises an air cylinder 14, a pushing plate 15 and a guide plate 16;
the cylinder 14 is arranged on one side of the conveyor belt 2 far away from the freeze-drying box 5, a push plate 15 is arranged between the cylinder 14 and the penicillin bottle group 8, the push plate 15 is arranged on a telescopic rod of the cylinder 14, the side wall, close to the conveyor belt 2, of the push plate 15 corresponds to the penicillin bottle group 8, the telescopic direction of the cylinder 14 is perpendicular to the front wall, close to the opening 7, of the freeze-drying box 5, the moving starting point position of the push plate 15 corresponds to the penicillin bottle group 8 on the conveyor belt 2, and the moving end point position of the push plate 15 corresponds to the inside of the cavity 13;
be provided with deflector 16 between conveyer belt 2 and the freeze-drying case 5, the up end of deflector 16 is parallel and level mutually with the up end of conveyer belt 2, xiLin bottle group 8 can be placed to the up end of deflector 16, the clearance between deflector 16 and conveyer belt 2 is less than xiLin bottle 1's diameter, the clearance between deflector 16 and the freeze-drying case 5 is less than xiLin bottle 1's diameter.
The cover taking assembly comprises a plurality of cover taking modules, a support module and a power module, the cover taking modules are rotatably arranged in a cavity 13 and can correspond to a cover plate 3 on a penicillin bottle group 8 in the cavity 13, the cover plate 3 is made of stainless steel, the power module comprises a rotating end and a lifting end, the rotating end of the power module can drive the cover taking modules to rotate, and the lifting end of the power module can drive the cover taking modules to lift;
the cover taking module comprises a support frame 17, the support frame 17 is located above the penicillin bottle group 8, the upper end face of the support frame 17 is attached to the lower end face of the cavity 13, a plurality of locking sub-modules used for locking the cover plate 3 on the lower end face of the support frame 17 are arranged on the side wall of the support frame 17, the upper end face of the cover plate 3 can be attached to the lower end face of the support frame 17, and a closed cavity can be formed among the cover plate 3, the support frame 17 and the lower end face of the cavity 13;
a rotating shaft 19 is arranged between the supporting frame 17 and the left side wall of the chamber 13, the axis of the rotating shaft 19 is parallel to a connecting line of the circle centers of the penicillin bottles 1 of the penicillin bottle group 8, one end of the rotating shaft 19 is connected to the supporting frame 17, the other end of the rotating shaft 19 rotatably penetrates through the first sealing sliding submodule and extends out of the freeze-drying box 5, the first sealing sliding submodule is arranged on the side wall of the freeze-drying box 5 in a lifting mode, a sleeve 20 is sleeved on an extending section of the freeze-drying box 5 of the rotating shaft 19, the sleeves 20 are all arranged on the supporting module, the supporting module is arranged on a lifting end of the power module, a chain disc 21 is further arranged on the extending section of the freeze-drying box 5 of the rotating shaft 19, a plurality of chain discs 21 of the cover taking modules are connected through chains 22 for transmission, and the chain discs 21 are connected with a rotating end of the power module;
a first steel pipe 23 is arranged between the supporting frame 17 and the right side wall of the cavity 13, the axis of the first steel pipe 23 is coincident with the axis of the axis, one end of the first steel pipe 23 penetrates through the side wall of the supporting frame 17 and is communicated with the closed cavity, the other end of the first steel pipe 23 rotatably penetrates through the second sealed sliding submodule and extends out of the freeze-drying box 5, the second sealed sliding submodule is arranged on the side wall of the freeze-drying box 5 in a lifting manner, and the extending section of the freeze-drying box 5 of the first steel pipe 23 is communicated with a vacuum system through an air pipe;
the supporting frame 17 is also provided with a second steel pipe 24, and the second steel pipe 24 penetrates through the side wall of the supporting frame 17 and is communicated with the cavity 13 and the sealing cavity 18;
a one-way valve 25 for controlling gas to flow from the cavity to the sealing cavity 18 is arranged in the second steel pipe 24;
a first clamping submodule and a second clamping submodule are arranged in the supporting frame 17, a plurality of penicillin bottle stoppers 26 are clamped between the first clamping submodule and the second clamping submodule, and the penicillin bottle stoppers 26 correspond to the bottle openings of the penicillin bottles 1;
the penicillin bottle stopper 26 comprises a stopper handle 27 and a stopper body 28, the stopper body 28 corresponds to the mouth of the penicillin bottle 1, and when the penicillin bottle group 8 is not placed in the cavity 13, the stopper handle 27 is located above the stopper body 28.
The locking sub-modules comprise lock catches 29, first sliding rods 30 and first springs 31;
first slide bar 30 slides and sets up in first spout 43, first spout 43 is seted up on the outer wall of carriage 17, the slip direction of first slide bar 30 is mutually perpendicular with the lateral wall of carriage 17, there is first spring 31 in the first spout 43, be connected through first spring 31 between first slide bar 30 and the first spout 43, first slide bar 30 stretches out first slide bar 30 carriage 17 and is connected with the hasp 29 that is used for locking apron 3, the distance between the terminal surface under the locking face of hasp 29 and the carriage 17 equals the thickness of apron 3, one side that the terminal surface is close to apron 3 under the hasp 29 is provided with direction inclined plane 45, direction inclined plane 45 is corresponding with apron 3.
The first sealing sliding submodule and the second sealing sliding submodule respectively comprise a through groove 32, a first groove 33, a second groove 34 and a sliding plate 35;
the side wall of the freeze-drying box 5 is provided with a through groove 32 penetrating through the inner wall and the outer wall of the freeze-drying box 5, the upper end face of the through groove 32 is provided with a first groove 33, the lower end face of the through groove 32 is provided with a second groove 34 with the same cross section as that of the first groove 33, the first groove 33 is positioned right above the second groove 34, the sliding plate 35 can slide along the first groove 33 and the second groove 34, and the sliding direction of the sliding plate 35 is perpendicular to the bottom end face of the freeze-drying box 5;
the rotating shaft 19 can rotatably penetrate through the sliding plate 35 of the first sealed sliding sub-module, and the first steel pipe 23 can rotatably penetrate through the sliding plate 35 of the second sealed sliding sub-module;
when the upper end surface of the supporting frame 17 is attached to the lower end surface of the cavity 13, the distance between the upper end surface of the sliding plate 35 and the rotating shaft 19 is a, the distance between the lower end surface of the first sliding block and the rotating shaft 19 is b, the distance between the upper end surface of the through groove 32 and the lower end surface of the through groove 32 is c, wherein a is greater than c, and b is greater than c.
The first clamping submodule and the second clamping submodule respectively comprise a clamping plate 36, a second sliding rod 37 and a second spring 38;
a second sliding rod 37 is arranged between the clamping plate 36 and the side wall of the supporting frame 17, the second sliding rod 37 is arranged in a second sliding groove 44 in a sliding manner, the second sliding groove 44 is formed in the inner wall of the supporting frame 17, the sliding direction of the second sliding rod 37 is perpendicular to the axis of the rotating shaft 19, a second spring 38 is arranged in the second sliding groove 44, and the second sliding rod 37 is connected with the second sliding groove 44 through the second spring 38;
and a plurality of stopper handles 27 of the penicillin bottle stopper 26 are clamped between the clamping blocks of the first clamping submodule and the clamping blocks of the second clamping submodule.
The support module comprises a support plate 39, the support plate 39 is connected with a plurality of sleeves 20, and the support plate 39 is arranged at the lifting end of the power module.
The power module comprises a motor 40 and an electric telescopic rod 41;
the motor 40 is connected to the support plate 39 through a motor base, and an output shaft of the motor 40 is connected with the chain disc 21;
the electric telescopic rod 41 is arranged on the bottom plate 42, the freeze-drying box 5 is further arranged on the bottom plate 42, the bottom plate 42 is arranged on the lifting hydraulic cylinder 6, the telescopic direction of the electric telescopic rod 41 is parallel to the sliding direction of the sliding plate 35, the telescopic end of the electric telescopic rod 41 is connected with the motor base, the bottom plate 42 is further provided with an inert gas generator, and the outlet of the inert gas generator is communicated with the interior of the freeze-drying box 5 through an air outlet pipe.
And the bottom plate is also provided with a refrigerating system and a heating system, and outlets of the refrigerating system and the heating system are communicated with the interior of the freeze-drying box 5.
The working principle is as follows: when the penicillin bottle group 8 on the conveyor belt 2 moves to the end position of the manipulator 9, the manipulator 9 is started, the sucker 10 is driven to extend into the water tank 11, so that the cover plate 3 is sucked from the water tank 11 and placed on the penicillin bottle group 8, the bottle mouth of the penicillin bottle group 8 is sealed, the penicillin bottle group 8 with the cover plate 3 covered is moved continuously, when the penicillin bottle group 8 moves to the pushing plate 15, the door plate 4 is opened, the air cylinder 14 is started, the pushing plate 15 is driven to push the penicillin bottle group 8 to move through the guide plate 16 and enter the cavity 13, when the penicillin bottle group 8 of the next cavity 13 is filled, the lifting hydraulic cylinder 6 is started to drive the freeze-drying box 5 to lift, so that the penicillin bottle group 8 of the previous cavity 13 is loaded, when all the cavities 13 are filled with the penicillin bottle group 8, the door plate 4 is closed, so that the freeze-drying box 5 is sealed, the electric telescopic rod 41 is started to drive the support frame 17 and the lock catch 29 to descend, thereby driving the cover plate 3 to contact with the latch 29, pushing the latch 29 to slide along the first slide bar 30, and stretching the first spring 31, when the cover plate 3 moves to the position above the latch 29, the latch 29 is reset under the driving of the first spring 31, thereby locking the cover plate 3 on the lower end surface of the support frame 17, starting the electric telescopic rod 41, driving the support frame 17 to ascend, and enabling the cover plate 3, the support frame 17 and the top wall of the cavity 13 to form a sealed closed cavity 18, thereby sealing the penicillin bottle stopper 26 in the closed cavity 18, starting the refrigeration system to cool the freeze-drying box, simultaneously starting the vacuum system through the one-way valve 25, the second steel pipe 24, the sealed cavity 18 and the first steel pipe 23, thereby reducing the pressure in the freeze-drying box 5, heating the freeze-drying box 5 through starting the heating system, thereby realizing the preparation of powder injection in the penicillin bottle, and starting the inert gas generator after the preparation is completed, fill into inert gas in the freeze-drying case 5, start electric telescopic handle 41 again simultaneously, drive carriage 17 and descend, when descending to suitable height, starter motor 40 through chain dish 21, chain 22 and pivot 19, drives carriage 17 and rotates to expose xiLin bottle plug 26, start electric telescopic handle 41 and drive xiLin bottle plug 26 and descend, thereby carry out the lid stopper to xiLin bottle 1, realize sealing the powder injection in xiLin bottle 1.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the above embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the embodiments of the invention without departing from the spirit and scope of the invention, which is to be covered by the claims.
Claims (10)
1. Preparation equipment of powder for injection, characterized in that it comprises a mobile capping unit, a lyophilization unit for the lyophilization of the drug in vials (1) and a conveyor belt (2);
the penicillin bottles (1) filled with liquid medicine are placed on the conveyor belt (2), a cover placing unit and a freeze-drying unit are sequentially arranged on one side of the conveyor belt (2) along the conveying direction of the conveyor belt (2), a cover plate (3) is arranged on the cover placing unit, the cover plate (3) corresponds to the bottle openings of a plurality of penicillin bottles (1), and the plurality of penicillin bottles (1) placed with the same cover plate (3) are penicillin bottle groups (8);
the freeze-drying unit comprises a door plate (4), a freeze-drying box (5), a pushing assembly and a cover taking assembly;
the freeze-drying box (5) is arranged on one side of the conveyor belt (2), the freeze-drying box (5) is positioned in front of the conveyor belt (2) in the conveying direction, the freeze-drying box (5) is arranged on a lifting hydraulic cylinder (6), the lifting direction of the lifting hydraulic cylinder (6) is perpendicular to the upper end face of the conveyor belt (2), an opening (7) is formed in one side, close to the conveyor belt (2), of the freeze-drying box (5), a door plate (4) capable of closing the opening (7) is rotatably arranged on the freeze-drying box (5), a pushing assembly is arranged on the opposite side, opposite to the freeze-drying box (5), of the conveyor belt (2), the pushing end of the pushing assembly can penetrate through the opening (7) and extend into the freeze-drying box (5), the pushing starting point of the pushing end of the pushing assembly corresponds to the penicillin bottle group (8) on the conveyor belt (2), and the pushing end point of the pushing end of the pushing assembly corresponds to the freeze-drying box (5), a cover taking assembly for taking down the cover plate (3) on the penicillin bottle group (8) is arranged in the freeze-drying box (5).
2. The apparatus for preparing powder for injection according to claim 1, wherein the capping unit comprises a robot arm (9), a suction cup (10), a water tank (11);
the automatic penicillin bottle group automatic feeding device is characterized in that a cover plate (3) is arranged in the water pool (11), the mechanical arm (9) is arranged on one side of the conveying belt (2) and located behind the conveying direction of the conveying belt (2), a sucking disc (10) is arranged on the mechanical arm (9), the sucking disc (10) can correspond to the upper end face of the cover plate (3), the movement starting point position of the mechanical arm (9) corresponds to the water pool (11), and the movement end point position of the mechanical arm (9) corresponds to the bottle opening of the penicillin bottle group (8).
3. The preparation equipment of powder for injection according to claim 1, characterized in that a plurality of baffles (12) parallel to each other are further arranged in the freeze-drying box (5), the baffles (12) are parallel to a bottom plate (42) of the freeze-drying box (5), the freeze-drying box (5) is divided into a plurality of chambers (13) by the baffles (12), cap taking assemblies are arranged on the inner top walls of the chambers (13), the cap taking assemblies correspond to the cover plates (3) on the penicillin bottle groups (8) in the chambers (13), and the penicillin bottle groups (8) can be placed on the bottom walls of the chambers (13).
4. The apparatus for preparing powder for injection according to claim 3, wherein the pushing assembly comprises a cylinder (14), a pushing plate (15), and a guiding plate (16);
the cylinder (14) is arranged on one side, far away from the freeze-drying box (5), of the conveyor belt (2), a pushing plate (15) is arranged between the cylinder (14) and the penicillin bottle group (8), the pushing plate (15) is arranged on a telescopic rod of the cylinder (14), the side wall, close to the conveyor belt (2), of the pushing plate (15) corresponds to the penicillin bottle group (8), the telescopic direction of the cylinder (14) is perpendicular to the front wall, close to the opening (7), of the freeze-drying box (5), the moving starting point position of the pushing plate (15) corresponds to the penicillin bottle group (8) on the conveyor belt (2), and the moving end point position of the pushing plate (15) corresponds to the inside of the cavity (13);
be provided with deflector (16) between conveyer belt (2) and freeze-drying case (5), deflector (16) up end and the up end looks parallel and level of conveyer belt (2), xiLin bottle group (8) can be placed to deflector (16) up end, the clearance between deflector (16) and conveyer belt (2) is less than the diameter of xiLin bottle (1), the clearance between deflector (16) and freeze-drying case (5) is less than the diameter of xiLin bottle (1).
5. The preparation equipment of powder for injection according to claim 3, wherein each cap taking assembly comprises a plurality of cap taking modules, a support module and a power module, the cap taking modules are rotatably arranged in the cavity (13), the cap taking modules can correspond to the cover plates (3) on the penicillin bottle groups (8) in the cavity (13), the cover plates (3) are made of stainless steel, the power module comprises a rotating end and a lifting end, the rotating end of the power module can drive the cap taking modules to rotate, and the lifting end of the power module can drive the cap taking modules to lift;
the cover taking module comprises a supporting frame (17), the supporting frame (17) is located above the penicillin bottle group (8), the upper end face of the supporting frame (17) is attached to the lower end face of the cavity (13), a plurality of locking sub-modules used for locking the cover plate (3) on the lower end face of the supporting frame (17) are arranged on the side wall of the supporting frame (17), the upper end face of the cover plate (3) can be attached to the lower end face of the supporting frame (17), and a closed cavity can be formed among the cover plate (3), the supporting frame (17) and the lower end face of the cavity (13);
a rotating shaft (19) is arranged between the supporting frame (17) and the left side wall of the cavity (13), the axis of the rotating shaft (19) is parallel to the connecting line of the circle center of each penicillin bottle (1) of each penicillin bottle group (8), one end of the rotating shaft (19) is connected onto the supporting frame (17), the other end of the rotating shaft (19) rotatably penetrates through the first sealing sliding submodule and extends out of the freeze-drying box (5), the first sealing sliding submodule is arranged on the side wall of the freeze-drying box (5) in a lifting mode, a sleeve (20) is sleeved on the extending section of the freeze-drying box (5) of the rotating shaft (19), the sleeves (20) are all arranged on the supporting module, the supporting module is arranged on the lifting end of the power module, a chain disc (21) is further arranged on the extending section of the freeze-drying box (5) of the rotating shaft (19), and the chain discs (21) of the cover taking module are connected and driven through a chain (22), the chain disc (21) is connected with the rotating end of the power module;
a first steel pipe (23) is arranged between the supporting frame (17) and the right side wall of the cavity (13), the axis of the first steel pipe (23) coincides with the axis of the axis, one end of the first steel pipe (23) penetrates through the side wall of the supporting frame (17) and is communicated with the sealed cavity, the other end of the first steel pipe (23) rotatably penetrates through the second sealed sliding submodule and extends out of the freeze-drying box (5), the second sealed sliding submodule is arranged on the side wall of the freeze-drying box (5) in a lifting mode, and the extending section of the freeze-drying box (5) of the first steel pipe (23) is communicated with a vacuum system through an air pipe;
the supporting frame (17) is also provided with a second steel pipe (24), and the second steel pipe (24) penetrates through the side wall of the supporting frame (17) and is communicated with the cavity (13) and the sealing cavity (18);
a one-way valve (25) used for controlling gas to flow from the cavity to the sealing cavity (18) is arranged in the second steel pipe (24);
a first clamping submodule and a second clamping submodule are arranged in the supporting frame (17), a plurality of penicillin bottle stoppers (26) are clamped between the first clamping submodule and the second clamping submodule, and the penicillin bottle stoppers (26) correspond to the bottle openings of the penicillin bottles (1);
the penicillin bottle stopper (26) comprises a stopper handle (27) and a stopper body (28), wherein the stopper body (28) corresponds to the bottle mouth of the penicillin bottle (1), and when the penicillin bottle group (8) is not placed in the cavity (13), the stopper handle (27) is positioned above the stopper body (28).
6. A device for the preparation of powders for injection according to claim 5, characterized in that the locking submodules each comprise a catch (29), a first slide (30), a first spring (31);
first slide bar (30) slide to set up in first spout (43), first spout (43) are seted up on the outer wall of carriage (17), the slip direction of first slide bar (30) is mutually perpendicular with the lateral wall of carriage (17), there is first spring (31) in first spout (43), be connected through first spring (31) between first slide bar (30) and first spout (43), first slide bar (30) stretch out first slide bar (30) carriage (17) and are connected with hasp (29) that are used for locking apron (3), the distance between the locking face of hasp (29) and carriage (17) lower terminal surface equals the thickness of apron (3), one side that the terminal surface is close to apron (3) under hasp (29) is provided with direction inclined plane (45), direction inclined plane (45) are corresponding with apron (3).
7. The apparatus for preparing powder for injection according to claim 5, wherein each of the first and second sealed sliding sub-modules comprises a through slot (32), a first groove (33), a second groove (34), a sliding plate (35);
the side wall of the freeze-drying box (5) is provided with a through groove (32) penetrating through the inner wall and the outer wall of the freeze-drying box, the upper end face of the through groove (32) is provided with a first groove (33), the lower end face of the through groove (32) is provided with a second groove (34) with the same cross section as that of the first groove (33), the first groove (33) is positioned right above the second groove (34), the sliding plate (35) can slide along the first groove (33) and the second groove (34), and the sliding direction of the sliding plate (35) is perpendicular to the bottom end face of the freeze-drying box (5);
the rotating shaft (19) can rotatably penetrate through a sliding plate (35) of the first sealed sliding sub-module, and the first steel pipe (23) can rotatably penetrate through a sliding plate (35) of the second sealed sliding sub-module;
when the upper end face of the supporting frame (17) is attached to the lower end face of the cavity (13), the distance between the upper end face of the sliding plate (35) and the rotating shaft (19) is a, the distance between the lower end face of the first sliding block and the rotating shaft (19) is b, the distance between the upper end face of the through groove (32) and the lower end face of the through groove (32) is c, wherein a is larger than c, and b is larger than c.
8. The apparatus for preparing powder for injection according to claim 5, wherein each of the first and second clamping sub-modules comprises a clamping plate (36), a second slide bar (37), a second spring (38);
a second sliding rod (37) is arranged between the clamping plate (36) and the side wall of the supporting frame (17), the second sliding rod (37) is arranged in a second sliding groove (44) in a sliding mode, the second sliding groove (44) is formed in the inner wall of the supporting frame (17), the sliding direction of the second sliding rod (37) is perpendicular to the axis of the rotating shaft (19), a second spring (38) is arranged in the second sliding groove (44), and the second sliding rod (37) is connected with the second sliding groove (44) through the second spring (38);
and a plurality of stopper handles (27) of penicillin bottle stoppers (26) are clamped between the clamping blocks of the first clamping submodule and the clamping blocks of the second clamping submodule.
9. A device for preparing powders for injection according to claim 5, wherein the support module comprises a support plate (39), the support plate (39) being connected to a plurality of sleeves (20), the support plate (39) being arranged at the lifting end of the power module.
10. The apparatus for preparing powder for injection according to claim 5, wherein the power module comprises a motor (40) and an electric telescopic rod (41);
the motor (40) is connected to the support plate (39) through a motor base, and an output shaft of the motor (40) is connected with a chain disc (21);
electric telescopic handle (41) set up on bottom plate (42), still be provided with freeze-drying case (5) on bottom plate (42), bottom plate (42) set up on hydraulic cylinder (6), the flexible direction of electric telescopic handle (41) parallels with the slip direction of sliding plate (35), the motor cabinet is connected to the flexible end of electric telescopic handle (41), still be provided with inert gas generator on bottom plate (42), the export of inert gas generator is through intercommunication in outlet duct and freeze-drying case (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111621525.3A CN114275249A (en) | 2021-12-28 | 2021-12-28 | Preparation equipment of powder for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111621525.3A CN114275249A (en) | 2021-12-28 | 2021-12-28 | Preparation equipment of powder for injection |
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| Publication Number | Publication Date |
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| CN114275249A true CN114275249A (en) | 2022-04-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111621525.3A Pending CN114275249A (en) | 2021-12-28 | 2021-12-28 | Preparation equipment of powder for injection |
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| CN (1) | CN114275249A (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114796093A (en) * | 2022-04-25 | 2022-07-29 | 正大制药（青岛）有限公司 | Production process for trehalose betaglucose for injection |
| CN117104591A (en) * | 2023-10-20 | 2023-11-24 | 江苏大同盟制药有限公司 | Automatic transmission and boxing device for freeze-dried powder injection penicillin bottles |
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| CN113002843A (en) * | 2021-01-28 | 2021-06-22 | 邹兴 | Automatic conveying and boxing device for freeze-dried powder injection vial |
| CN214570586U (en) * | 2021-02-07 | 2021-11-02 | 康美氏（厦门）生物科技有限公司 | Cosmetics xiLin bottle capper |
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| CN104743160A (en) * | 2013-12-31 | 2015-07-01 | 楚天科技股份有限公司 | Automatic feeding and discharging pushing rod device of freeze dryer |
| CN205098496U (en) * | 2015-10-27 | 2016-03-23 | 长安大学 | Packaging hardware in advance of medicine bottle of built -in drier |
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| CN117104591B (en) * | 2023-10-20 | 2023-12-26 | 江苏大同盟制药有限公司 | Automatic transmission and boxing device for freeze-dried powder injection penicillin bottles |
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