CN114272515A

CN114272515A - Programmable device and implantable neurostimulation system

Info

Publication number: CN114272515A
Application number: CN202111615735.1A
Authority: CN
Inventors: 马艳
Original assignee: Sceneray Co Ltd
Current assignee: Sceneray Co Ltd
Priority date: 2021-12-27
Filing date: 2021-12-27
Publication date: 2022-04-05
Also published as: WO2023124390A1

Abstract

The present application provides a programming device and an implantable neurostimulation system, the programming device comprising: a touch screen configured to receive an operation of a user; a communication module configured to enable data interaction between the programming device and a stimulator; a controller electrically connected with the touch screen and the communication module, respectively, the controller configured to: receiving a sliding operation by using the touch screen, and responding to the sliding operation to obtain a configuration parameter value of a target parameter; and generating a control instruction based on the configuration parameter value of the target parameter and sending the control instruction to the stimulator so that the stimulator generates and applies the electrical stimulation to the in-vivo tissue of the patient according to the control instruction. The user can set up the parameter value through gliding mode, has significantly reduced user's operating procedure for the parameter value sets up more fast convenient, promotes user's use and experiences.

Description

Programmable device and implantable neurostimulation system

Technical Field

The present application relates to the field of implantable medical device technology, and more particularly, to a programmable device and an implantable neurostimulation system.

Background

The implanted nerve stimulation system mainly comprises a stimulator implanted in a body and a program control device in vitro. The nerve regulation and control technology is mainly characterized in that electrodes are implanted into a specific structure (namely a target point) in a body through a stereotactic operation, and a stimulator implanted into the body of a patient sends electric pulses to the target point through the electrodes to regulate and control the electric activities and functions of corresponding nerve structures and networks, so that symptoms are improved, and pain is relieved.

The existing program control equipment needs to input specific numerical values or gradually adjust through multiple key operations when setting parameter values, the parameter value setting efficiency is low, and the use experience of a user is poor.

Disclosure of Invention

The application aims to provide a program-controlled device and an implanted nerve stimulation system, so that the operation steps of a user are greatly reduced, the setting of a parameter value is more rapid and convenient, and the use experience of the user is improved.

The purpose of the application is realized by adopting the following technical scheme:

in a first aspect, the present application provides a programming device for use in an implantable neurostimulation system, which includes the programming device disposed outside a patient and a stimulator implanted in the patient;

the programming device communicatively coupled with the stimulator, the programming device comprising:

a touch screen configured to receive an operation of a user;

a communication module configured to enable data interaction between the programming device and the stimulator;

a controller electrically connected with the touch screen and the communication module, respectively, the controller configured to:

receiving a sliding operation by using the touch screen, and responding to the sliding operation to obtain a configuration parameter value of a target parameter;

and generating a control instruction based on the configuration parameter value of the target parameter and sending the control instruction to the stimulator so that the stimulator generates and applies the electrical stimulation to the in-vivo tissue of the patient according to the control instruction.

The technical scheme has the beneficial effects that: generally speaking, current programme-controlled equipment need input specific numerical value when setting up the parameter value or progressively adjust through the operation of pressing a button many times, and the parameter value sets up inefficiency, and the programme-controlled equipment of this application can support user's sliding operation, and the user can set up the parameter value through gliding mode, and the user's that has significantly reduced operating procedure for the parameter value sets up more fast convenient, promotes user's use and experiences.

In some optional embodiments, the controller is further configured to obtain the configuration parameter value of the target parameter by:

responding to the sliding operation, and acquiring a sliding path corresponding to the target parameter;

when the position of each track point of the sliding path is detected to be in a preset sliding area, acquiring a reference path corresponding to the sliding path based on a starting point, an end point and a path direction of the sliding path, wherein the reference path is a part of a preset circular path, the path direction of the reference path is determined by the path direction of the sliding path, and the preset circular path is in the preset sliding area;

acquiring the similarity of the sliding path and the reference path;

and when the similarity is not less than a preset similarity threshold, acquiring a configuration parameter value of the target parameter based on the reference path.

The technical scheme has the beneficial effects that: whether the misoperation exists or not is judged by using the detection process in the two stages, the configuration parameter value is acquired only when the sliding operation is judged not to be the misoperation, when the position of each track point of the sliding path is detected in the first stage and is in the preset sliding area, the calculation of the configuration parameter value is not directly carried out, but the detection in the second stage is entered, when the similarity is detected not to be smaller than the preset similarity threshold value, the sliding operation is determined not to be the misoperation, the configuration parameter value is further acquired, the detection process in the two stages can play a role in double insurance, the situation that the unreasonable parameter value is set due to the misoperation of a user is avoided, and the life safety of the patient is guaranteed.

Specifically, in the first stage, detecting whether the positions of the track points of the sliding path are all in a preset sliding region, and when detecting that the positions of the track points of the sliding path are all in the preset sliding region, indicating that a user may have an intention to configure parameters, then entering the second stage; in the second stage, based on the starting point, the end point and the path direction of the sliding path, a reference path corresponding to the sliding path is obtained, the similarity between the sliding path and the reference path is obtained, whether the similarity is not smaller than a preset similarity threshold value is detected, and when the similarity is not smaller than the preset similarity threshold value, it can be determined that the sliding operation is not a misoperation.

In some optional embodiments, the controller is further configured to:

before detecting whether the positions of all track points of the sliding path are in the preset sliding area, detecting whether the starting point of the sliding path is in an effective starting point range, wherein the effective starting point range comprises position points on the touch screen corresponding to the current parameter value of the target parameter;

if the starting point of the sliding path is in the effective starting point range, detecting whether the positions of all track points of the sliding path are in the preset sliding area;

and if the starting point of the sliding path is not in the effective starting point range, no operation is performed, or the user is prompted to perform the operation again, or an area corresponding to the effective starting point range is displayed on the touch screen in a flashing state.

The technical scheme has the beneficial effects that: whether the starting point of the sliding path is in the effective starting point range or not is detected, if the starting point of the sliding path is not in the effective starting point range, the fact that the sliding operation is possibly misoperation of a user is indicated, at the moment, no operation can be done, the user is indirectly prompted to be invalid through a non-reaction mode after the sliding operation, or the user is directly prompted to conduct re-operation, or a region corresponding to the effective starting point range is displayed on a touch screen in a flickering mode, any one of the processing modes can play a role in prompting the user that the sliding operation is invalid at this time, and the intelligent degree is high.

In some optional embodiments, the controller is further configured to obtain the reference path by:

finding a point which is closest to the starting point of the sliding path on the preset circular path to serve as the starting point of the reference path;

finding a point which is closest to the end point of the sliding path on the preset circular path to serve as the end point of the reference path;

and based on the path direction of the sliding path, cutting a path from the starting point to the end point of the reference path from the preset circular path to be used as the reference path.

The technical scheme has the beneficial effects that: the method comprises the steps of taking a point on a preset circular path, which is closest to a starting point of a sliding path, as a starting point of a reference path, taking a point on the preset circular path, which is closest to an end point of the sliding path, as an end point of the reference path, and intercepting a path between the starting point and the end point of the reference path along the path direction of the sliding path in the preset circular path, as the reference path, so that the obtained reference path is more fit with the sliding path, and the corresponding configuration parameter value is more reasonable to obtain according to the reference path, and the intention of a user in configuring the parameter can be truly reflected.

In some optional embodiments, the controller is further configured to obtain the similarity in the following manner:

obtaining a plurality of similarity training data, wherein each similarity training data comprises a sample sliding path used for training, a sample reference path and the labeling similarity of the sample sliding path and the sample reference path;

training a preset deep learning model by using a plurality of similarity training data to obtain a similarity model;

and inputting the sliding path and the reference path into the similarity model to obtain the similarity.

The technical scheme has the beneficial effects that: the preset deep learning model can be trained according to the similarity training data to obtain the similarity model, corresponding similarity can be automatically generated in real time only by inputting the sliding path and the reference path into the similarity model, and the intelligent degree is high. Through design, a proper amount of neuron calculation nodes and a multilayer operation hierarchical structure are established, a proper input layer and a proper output layer are selected, a preset deep learning model can be obtained, through learning and tuning of the preset deep learning model, a functional relation from input to output is established, although the functional relation between input and output cannot be found 100%, the functional relation can be close to a real incidence relation as far as possible, and the similarity model obtained through training can output corresponding similarity in real time and has high reliability of an output result.

In some optional embodiments, the controller is further configured to obtain the preset similarity threshold by:

acquiring a first corresponding relation between the disease type and a similarity threshold;

and acquiring a similarity threshold corresponding to the disease type of the patient as the preset similarity threshold based on the disease type of the patient and the first corresponding relation.

The technical scheme has the beneficial effects that: the ability of the hand control of the patient that the disease type is different is probably different, compare in the patient that hand control power is strong, the deviation of the relatively poor parkinson patient of hand control power slip path and preset circumference route when sliding probably is great, and the similarity probably is lower, to the patient of different disease types, adopt different preset similarity threshold values for programme-controlled equipment can support the relatively poor patient of hand control power and carry out the sliding operation, greatly reduced the operation degree of difficulty of patient when using programme-controlled equipment.

obtaining the measuring range of the target parameter corresponding to the preset circumferential path;

and determining a configuration parameter value of the target parameter based on the ratio of the lengths of the reference path and the preset circular path and the measuring range of the target parameter.

The technical scheme has the beneficial effects that: the parameter value of the target parameter can be adjusted steplessly based on the length ratio of the reference path to the preset circumferential path and the range of the target parameter, and the configuration parameter value of the target parameter can be any value in the range of the target parameter, so that the requirement in practical application is met.

In some optional embodiments, the preset circumferential path is provided with at least one scale, and the controller is further configured to obtain the configuration parameter value of the target parameter by:

acquiring the measuring range of the target parameter corresponding to the preset circumferential path and the set value of the target parameter corresponding to each scale of the preset circumferential path;

and determining the configuration parameter value of the target parameter based on the set value of the target parameter corresponding to the scale closest to the end point of the reference path.

The technical scheme has the beneficial effects that: the parameter value of the target parameter can be adjusted to obtain the configuration parameter value of the target parameter based on the set value of the target parameter corresponding to the scale closest to the reference path, and the configuration parameter value of the target parameter can be one of the set values of the target parameter corresponding to the scales, so that the requirements in practical application are met.

In some optional embodiments, the controller obtains the range of the target parameter by:

acquiring a second corresponding relation between a configuration parameter value of an associated parameter and the measuring range of the target parameter, wherein the associated parameter is one or more parameters except the target parameter in the parameters of the stimulator;

and acquiring the range of the target parameter based on the configuration parameter value of the associated parameter and the second corresponding relation.

The technical scheme has the beneficial effects that: the configuration process of each parameter of the stimulator is not isolated, and the configuration parameter value of each parameter is associated with the range of other parameters, so that the configuration process can be completed only in a relatively reasonable range when the parameters are set, thereby avoiding unreasonable parameter values set by a user and ensuring the life safety of a patient.

In some optional embodiments, N scales are sequentially arranged on the preset circumferential path along a clockwise direction of the preset circumferential path, a difference between a set value of the target parameter corresponding to a kth scale and a set value of the target parameter corresponding to a (k-1) th scale is smaller than a difference between a set value of the target parameter corresponding to a (k + 1) th scale and a set value of the target parameter corresponding to a kth scale, N is an integer greater than 2, and k is an integer greater than 1 and smaller than N.

The technical scheme has the beneficial effects that: along the clockwise direction of the preset circular path, the difference value of the set values of the target parameters corresponding to the two adjacent scales is larger and larger, so that the amplitude change of the set values corresponding to the track points is faster gradually in the process of clockwise sliding of a user, and the setting efficiency of the parameter values is further improved.

In some optional embodiments, the controller is further configured to:

and when the position of any one track point of the sliding path is detected not to be in the preset sliding area, no operation is performed, or the user is prompted to operate again, or the preset sliding area is displayed on the touch screen in a flashing state.

The technical scheme has the beneficial effects that: when the position of any one track point of the sliding path is not in the preset sliding area, the sliding operation is possibly caused by misoperation of a user, the sliding operation is judged to be invalid, at the moment, no operation can be performed, the sliding operation invalidity of the user is indirectly prompted in a non-reaction mode after the sliding operation, or the user is prompted to operate again, or the preset sliding area is displayed on the touch screen in a flashing state, the effect of prompting the user that the sliding operation is invalid at this time can be achieved through any one of the processing modes, and the intelligent degree is high.

In some optional embodiments, the controller is further configured to:

and when the similarity is smaller than the preset similarity threshold, no operation is performed, or a user is prompted to perform the operation again, or the preset circular path is displayed on the touch screen in a flashing state.

The technical scheme has the beneficial effects that: when the similarity is smaller than the preset similarity threshold, the sliding operation is possibly caused by the fact that the user touches the touch screen by mistake, the sliding operation is judged to be invalid, at the moment, no operation can be performed, the user is indirectly prompted to be invalid in a non-response mode after the sliding operation, or the user is prompted to operate again, or a preset circular path is displayed on the touch screen in a flashing state, the user can be prompted to be invalid in the sliding operation, and the intelligent degree is high.

In some optional embodiments, the target parameter is any one of a pulse width parameter, a magnitude parameter, and a frequency parameter of the voltage.

The technical scheme has the beneficial effects that: the target parameter can be any one of a pulse width parameter, an amplitude parameter and a frequency parameter of the voltage, so that the program control device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter, and the requirements of practical application are met.

In some alternative embodiments, the patient's disease type comprises one or more of epilepsy, tremor, parkinson's disease, depression, obsessive compulsive disorder, alzheimer's disease, and drug addiction.

The technical scheme has the beneficial effects that: the program control equipment can be used for controlling stimulators in patients with different disease types, and the application range is wide.

In a second aspect, the present application provides an implantable neurostimulation system, which includes the programming device disposed outside of a patient and a stimulator implanted within the patient;

the stimulator is configured to generate and apply electrical stimulation to in vivo tissue of the patient;

a touch screen configured to receive an operation of a user;

and generating a control instruction based on the configuration parameter value of the target parameter and sending the control instruction to the stimulator so that the stimulator generates the electrical stimulation according to the control instruction.

The technical scheme has the beneficial effects that: the implantable neural stimulation system can support sliding operation of a user, the user can set parameter values in a sliding mode, operation steps of the user are greatly reduced, parameter values can be set more quickly and conveniently, and use experience of the user is improved.

Drawings

The present application is further described below with reference to the drawings and examples.

Fig. 1 is a schematic flowchart of a control method of a program control device according to an embodiment of the present disclosure;

fig. 2 is a schematic flowchart of obtaining a configuration parameter value of a target parameter according to an embodiment of the present disclosure;

FIG. 3 is a schematic diagram of a display interface of a touch screen provided in an embodiment of the present application;

fig. 4 is a schematic flowchart of another control method for a programmable device according to an embodiment of the present application;

fig. 5 is a schematic flowchart of acquiring a reference path according to an embodiment of the present disclosure;

fig. 6 is a schematic flowchart of obtaining similarity according to an embodiment of the present disclosure;

fig. 7 is a schematic flowchart of a process for obtaining a preset similarity threshold according to an embodiment of the present disclosure;

fig. 8 is a schematic flowchart of another process for obtaining configuration parameter values of target parameters according to an embodiment of the present application;

fig. 9 is a schematic flowchart of another process for obtaining configuration parameter values of a target parameter according to an embodiment of the present application;

fig. 10 is a partial flowchart of a control method of a program control device according to an embodiment of the present application;

fig. 11 is a partial schematic flow chart of a control method of another programmable device according to an embodiment of the present application;

fig. 12 is a block diagram of a program control device according to an embodiment of the present disclosure;

fig. 13 is a block diagram of an implantable neurostimulation system according to an embodiment of the present disclosure.

Detailed Description

The present application is further described with reference to the accompanying drawings and the detailed description, and it should be noted that, in the present application, the embodiments or technical features described below may be arbitrarily combined to form a new embodiment without conflict.

Referring to fig. 1, an embodiment of the present application provides a control method of a programming device, which is applied to an implantable neurostimulation system, where the implantable neurostimulation system includes the programming device disposed outside a patient and a stimulator implanted in the patient;

a touch screen configured to receive an operation of a user;

the method comprises a step S101 to a step S102.

Step S101: receiving a sliding operation by using the touch screen, and responding to the sliding operation to obtain a configuration parameter value of a target parameter;

step S102: and generating a control instruction based on the configuration parameter value of the target parameter and sending the control instruction to the stimulator so that the stimulator generates and applies the electrical stimulation to the in-vivo tissue of the patient according to the control instruction.

Generally speaking, current programme-controlled equipment need input specific numerical value when setting up the parameter value or progressively adjust through the operation of pressing a button many times, and the parameter value sets up inefficiency, and the programme-controlled equipment of this application can support user's sliding operation, and the user can set up the parameter value through gliding mode, and the user's that has significantly reduced operating procedure for the parameter value sets up more fast convenient, promotes user's use and experiences.

The stimulator may be any one of an Implantable nerve electrical stimulation device, an Implantable cardiac electrical stimulation System (also called cardiac pacemaker), an Implantable Drug Delivery System (I DDS for short), and a lead switching device. Examples of the implantable neural electrical Stimulation device include Deep Brain Stimulation (DBS), Cortical Brain Stimulation (CNS), Spinal Cord Stimulation (SCS), Sacral Nerve Stimulation (SNS), and Vagal Nerve Stimulation (VNS). The stimulator is disposed within the patient for providing electrical stimulation.

Programmed devices may include, but are not limited to: smart phones (such as Android phones, iOS phones, etc.), tablet computers, portable personal computers, Mobile Internet Devices (MID), and other Devices, which are not limited in the embodiments of the present application.

In some embodiments, the programming device may include a physician programming device and/or a patient programming device.

The patient programming device is provided for the patient, who can use the patient programming device to adjust the parameters of the respective stimulator. Specifically, a corresponding preset adjustment range may be set based on the disease information of the patient, and the patient may only adjust the parameters of the corresponding stimulator within the corresponding preset adjustment range.

The doctor program control equipment is equipped for doctors, and one doctor program control equipment can utilize the communication module to respectively carry out data interaction with stimulators of a plurality of patients.

In some implementations, the communication module may include a wired communication module and/or a wireless communication module.

The wired communication module may include one or more of a fiber optic communication unit, a coaxial cable communication unit, an open wire communication unit, a waveguide communication unit, and an opto-electronic communication unit; the wireless communication module may include one or more of a 4G communication unit, a 5G communication unit, a WIFI communication unit, a near field communication unit, a WiGig communication unit, a bluetooth communication unit, a ZigBee communication unit, a microwave communication unit, a satellite communication unit, and an atmospheric laser communication unit.

The wired communication module is stable, and has high reliability and high transmission rate; the wireless communication module has longer communication distance, is not limited by wires, has certain mobility, can communicate through wireless connection in a mobile state, and has lower cost.

In some embodiments, the touch screen may include any one of a resistive touch screen, a capacitive touch screen, and a surface acoustic wave screen.

In some alternative embodiments, the target parameter may be any one of a pulse width parameter, a magnitude parameter, and a frequency parameter of the voltage.

In some alternative embodiments, the target parameter may be any one of a pulse width parameter, a magnitude parameter, and a frequency parameter of the current.

Therefore, the target parameter can be any one of a pulse width parameter, an amplitude parameter and a frequency parameter, so that the program control device can control the stimulator to apply corresponding electrical stimulation to the patient based on the configuration parameter value of the target parameter, and the requirements of practical application are met.

Referring to fig. 2, in some alternative embodiments, the step S101 may include steps S201 to S204.

Step S201: responding to the sliding operation, and acquiring a sliding path corresponding to the target parameter;

step S202: when the position of each track point of the sliding path is detected to be in a preset sliding area, acquiring a reference path corresponding to the sliding path based on a starting point, an end point and a path direction of the sliding path, wherein the reference path is a part of a preset circular path, the path direction of the reference path is determined by the path direction of the sliding path, and the preset circular path is in the preset sliding area;

step S203: acquiring the similarity of the sliding path and the reference path;

step S204: and when the similarity is not less than a preset similarity threshold, acquiring a configuration parameter value of the target parameter based on the reference path.

Therefore, whether misoperation exists or not is judged by using the detection process in the two stages, the configuration parameter value is acquired only when the sliding operation is judged not to be the misoperation, when the positions of all track points of the sliding path detected in the first stage are in the preset sliding area, the configuration parameter value is not directly calculated, the second stage detection is entered, when the similarity is detected not to be smaller than the preset similarity threshold value, the sliding operation is determined not to be the misoperation, the configuration parameter value is further acquired, the detection process in the two stages can play a role in double insurance, the situation that the user sets unreasonable parameter values due to the misoperation is avoided, and the life safety of the patient is guaranteed.

Referring to fig. 3, in some embodiments, the shape of the preset sliding area may be a circular ring concentric with the preset circumferential path.

The length of the sliding path is not limited, the user can slide for less than one circle along the preset sliding area of the touch screen, and the user can also slide for multiple circles (the total number of circles can be not an integer) along the preset sliding area of the touch screen.

The reference path may be less than one predetermined circumferential path, may be one predetermined circumferential path, or may be a non-integer number of predetermined circumferential paths (e.g., 1.5, 3.5, etc.). When the user slides for 0.3 turn, the reference path is, for example, a 0.3 turn preset circumferential path; when the user slides for 1 turn, the reference path is, for example, 1 turn of the preset circumferential path; when the user slides 4.5 turns, the reference path is, for example, 4.5 turns of the preset circular path.

Referring to fig. 3 and 4, in some alternative embodiments, the method may further include step S205 to step S207.

Step S205: before step S202, detecting whether a starting point of the sliding path is in an effective starting point range, where the effective starting point range includes a position point on the touch screen corresponding to a current parameter value of the target parameter;

step S206: if the starting point of the sliding path is in the effective starting point range, detecting whether the positions of all track points of the sliding path are in the preset sliding area;

step S207: and if the starting point of the sliding path is not in the effective starting point range, no operation is performed, or the user is prompted to perform the operation again, or an area corresponding to the effective starting point range is displayed on the touch screen in a flashing state.

Therefore, whether the starting point of the sliding path is in the effective starting point range or not is detected, if the starting point of the sliding path is not in the effective starting point range, the fact that the sliding operation is possibly misoperation of the user is indicated, at the moment, no operation can be done, the user is indirectly prompted to be invalid in a non-reaction mode after the sliding operation, or the user is directly prompted to conduct re-operation, or a region corresponding to the effective starting point range is displayed on the touch screen in a flickering mode, any one of the processing modes can play a role in prompting the user that the sliding operation is invalid at this time, and the intelligent degree is high.

The effective starting point range is, for example, a circle with a preset size as a radius and a position point on the touch screen corresponding to the current parameter value of the target parameter as a circle center; or, the effective starting point range is, for example, a square with a preset size as a side length, and the center of the position point on the touch screen corresponding to the current parameter value of the target parameter is the position point. The predetermined size is, for example, 8mm, 10mm or 20 mm.

Referring to fig. 5, in some alternative embodiments, the step S202 may include steps S301 to S303.

Step S301: finding a point which is closest to the starting point of the sliding path on the preset circular path to serve as the starting point of the reference path;

step S302: finding a point which is closest to the end point of the sliding path on the preset circular path to serve as the end point of the reference path;

step S303: and based on the path direction of the sliding path, cutting a path from the starting point to the end point of the reference path from the preset circular path to be used as the reference path.

Therefore, a point on the preset circular path, which is closest to the starting point of the sliding path, is used as the starting point of the reference path, a point on the preset circular path, which is closest to the end point of the sliding path, is used as the end point of the reference path, and a path between the starting point and the end point of the reference path along the path direction of the sliding path in the preset circular path is intercepted and used as the reference path, so that the obtained reference path is more fit with the sliding path, the corresponding configuration parameter value is more reasonable to obtain according to the reference path, and the intention of a user in configuring the parameter can be truly reflected.

Referring to fig. 6, in some alternative embodiments, the step S203 may include steps S401 to S403.

Step S401: obtaining a plurality of similarity training data, wherein each similarity training data comprises a sample sliding path used for training, a sample reference path and the labeling similarity of the sample sliding path and the sample reference path;

step S402: training a preset deep learning model by using a plurality of similarity training data to obtain a similarity model;

step S403: and inputting the sliding path and the reference path into the similarity model to obtain the similarity.

Therefore, a preset deep learning model can be trained according to the similarity training data to obtain a similarity model, corresponding similarities can be automatically generated in real time only by inputting the sliding path and the reference path into the similarity model, and the intelligent degree is high. Through design, a proper amount of neuron calculation nodes and a multilayer operation hierarchical structure are established, a proper input layer and a proper output layer are selected, a preset deep learning model can be obtained, through learning and tuning of the preset deep learning model, a functional relation from input to output is established, although the functional relation between input and output cannot be found 100%, the functional relation can be close to a real incidence relation as far as possible, and the similarity model obtained through training can output corresponding similarity in real time and has high reliability of an output result.

Referring to fig. 7, in some alternative embodiments, the preset similarity threshold may be obtained in steps S501 to S502.

Step S501: acquiring a first corresponding relation between the disease type and a similarity threshold;

step S502: and acquiring a similarity threshold corresponding to the disease type of the patient as the preset similarity threshold based on the disease type of the patient and the first corresponding relation.

Therefore, the hand control capability of patients with different disease types is possibly different, compared with the patients with strong hand control force, the deviation between the sliding path and the preset circumferential path of the Parkinson patient with poor hand control force during sliding is possibly larger, the similarity is possibly lower, different preset similarity threshold values are adopted for the patients with different disease types, the program control equipment can support the patient with poor hand control force to perform sliding operation, and the operation difficulty of the patient when the program control equipment is used is greatly reduced.

In a specific application, the threshold of similarity for parkinson's disease is 60%, the threshold of similarity for depression is 80%, and the threshold of similarity for drug addiction is 85%.

For example, if Zhang III is a Parkinson patient, the preset similarity threshold of Zhang III is 60%. When the disease type of the patient is more than one, the lowest one of the similarity thresholds corresponding to all disease types of the patient can be used as the preset similarity threshold of the patient.

The programmable device of the present application is not limited to the types of diseases that can be used, including but not limited to: convulsive disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., Major Depressive Disorder (MDD)), manic depression, anxiety, post-traumatic stress disorder, depression, Obsessive Compulsive Disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., tremor or parkinson's disease), huntington's disease, alzheimer's disease, drug addiction, or other neurological or psychiatric diseases and injuries. When the program control device is used for treating drug addiction patients, the program control device can help drug addicts to abstain drugs and improve the happiness and life quality of the drug addicts.

Therefore, the stimulator in the patient with different disease types can be controlled by the program control equipment, and the application range is wide.

Referring to fig. 8, in some alternative embodiments, the step S204 may include steps S601 to S602.

Step S601: obtaining the measuring range of the target parameter corresponding to the preset circumferential path;

step S602: and determining a configuration parameter value of the target parameter based on the ratio of the lengths of the reference path and the preset circular path and the measuring range of the target parameter.

The measuring range of the target parameter is used for indicating a first set value and a second set value of the target parameter.

The range refers to the measurement range of the metrology tool, and is determined by the division value and the maximum measurement value of the metrology tool. The range of the meter is the difference between the upper limit and the lower limit of the nominal range of the meter. If the lower measurement limit of the meter is zero, the maximum value of the physical quantity which can be measured is equal to the measuring range.

Therefore, the parameter value of the target parameter can be adjusted steplessly based on the length ratio of the reference path to the preset circumferential path and the range of the target parameter, and the configuration parameter value of the target parameter can be any value in the range of the target parameter, so that the requirement in practical application is met.

In some embodiments, the step S602 may include:

determining a configuration parameter value of the target parameter based on a ratio of the length of the reference path to the preset circular path, a path direction of the reference path, a current parameter value of the target parameter, and a range of the target parameter.

When the reference path is less than one preset circumferential path, the first set value of the target parameter may be a minimum set value of the target parameter, and the second set value of the target parameter may be a maximum set value of the target parameter. Generally, the configuration parameter values are in a range between a minimum set point and a maximum set point.

In one specific application, the target parameter is a voltage pulse width parameter of the stimulator, the range of the voltage pulse width parameter is 0-960 μ s, the first set value of the voltage pulse width parameter is 0 μ s, and the second set value of the voltage pulse width parameter is 960 μ s.

The ratio of the lengths of the reference path and the predetermined circumferential path is 0.5, the path direction of the reference path is clockwise, the current parameter value of the voltage pulse width parameter is 20 μ s, and the configuration parameter value of the voltage pulse width parameter is 20 μ s +0.5 × (960-0) μ s, which is 500 μ s.

When the reference path is more than one (non-integral multiple) preset circumferential path (e.g., 1.5, 3.5, etc.), the first set value and the second set value of the target parameter may both be in a range between the minimum set value and the maximum set value of the target parameter.

The mode can support the user to slide for a plurality of circles along the preset sliding area of the touch screen, when the adjusting range of the parameter value of the target parameter is large, if only the user is allowed to slide for one circle, the user inconveniently carries out fine control in the range of the one circle, the parameter value is set to be higher or lower easily, the program control equipment can support the user to slide for a plurality of circles along the preset sliding area of the touch screen, and the user can conveniently carry out fine adjustment.

In one embodiment, the target parameter is a voltage amplitude parameter of the stimulator, the first set value of the voltage amplitude parameter is 0V, and the second set value of the voltage amplitude parameter is 0.6V.

The reference paths are 3.5 preset circular paths, the length ratio of the reference paths to the preset circular paths is 3.5, the path direction of the reference paths is counterclockwise, the current parameter value of the voltage amplitude parameter is 2.35V, and the configuration parameter value of the voltage amplitude parameter is 2.35V-3.5 × (0.6-0) V ═ 0.25V.

Referring to fig. 9, in some alternative embodiments, the preset circumferential path is provided with at least one scale, and the step S204 may include steps S701 to S702.

Step S701: acquiring the measuring range of the target parameter corresponding to the preset circumferential path and the set value of the target parameter corresponding to each scale of the preset circumferential path;

step S702: and determining the configuration parameter value of the target parameter based on the set value of the target parameter corresponding to the scale closest to the reference path.

Therefore, the parameter value of the target parameter can be adjusted to obtain the configuration parameter value of the target parameter based on the set value of the target parameter corresponding to the scale closest to the reference path, and the configuration parameter value of the target parameter can be one of the set values of the target parameter corresponding to the scales, so that the requirements in practical application are met.

In a specific application, the target parameter is a voltage pulse width parameter, the preset circumferential path is provided with 20 scales, the set values of the voltage pulse width parameter corresponding to the 20 scales are 20 μ s, 40 μ s, 60 μ s, 80 μ s, 100 μ s and 120 μ s … … 960 μ s in sequence, the scale closest to the end point of the reference path is the 4 th scale, and the configuration parameter value of the voltage pulse width parameter is 80 μ s.

In some optional embodiments, the step S601 or the step S701 obtains the measurement range of the target parameter by:

acquiring a second corresponding relation between a configuration parameter value of an associated parameter and the measuring range of the target parameter, wherein the associated parameter is one or more parameters except the target parameter in the parameters of the stimulator; (the target parameter is one of the parameters of the stimulator, the parameters of the stimulator including a plurality of a constant current amplitude parameter, a constant current frequency parameter, a constant voltage amplitude parameter, a constant voltage pulse width parameter, and a constant voltage frequency parameter.)

Therefore, the configuration process of each parameter of the stimulator is not isolated, and the configuration parameter value of each parameter is associated with the range of other parameters, so that the configuration process can be completed only in a relatively reasonable range when the parameters are set, thereby avoiding the user from setting unreasonable parameter values and ensuring the life safety of patients.

In some optional embodiments, the preset circular path is provided with a plurality of scales, the reference path corresponding to the sliding path is not greater than 1 preset circular path, and the measuring range of the target parameter is used for indicating the minimum set value and the maximum set value of the target parameter.

In some optional embodiments, the target parameter's range includes an operable portion and an inoperable portion, the method further comprising: displaying scales corresponding to an operable part of the measuring range of the target parameter in a first state on the touch screen, and displaying scales except for scales corresponding to an inoperable part of the measuring range of the target parameter in a second state on the touch screen;

when the scale closest to the end point of the reference path is detected to be in the scale range corresponding to the inoperable part of the measuring range of the target parameter, no operation is performed, or the user is prompted to operate again, or the scale corresponding to the operable part of the measuring range of the target parameter is displayed on the touch screen in a flickering state.

In a specific application, the corresponding target parameter is a voltage frequency parameter, the associated parameter corresponding to the voltage frequency parameter is a voltage amplitude parameter, and the configuration parameter value of the voltage amplitude parameter is 0.2V, so that the measuring range of the voltage frequency parameter is 40 Hz-120 Hz; and when the configuration parameter value of the voltage amplitude parameter is 0.3V, the range of the voltage frequency parameter can be 60 Hz-160 Hz.

The preset circular path is provided with 8 scales, and when the voltage frequency parameter is set, the set values corresponding to the 8 scales are 20Hz, 40Hz, 60Hz, 80Hz, 100Hz, 120Hz, 140Hz and 160Hz in sequence. The scales corresponding to the operable portion of the range of the voltage frequency parameter include the 2 nd scale to the 6 th scale.

The 2 nd to 6 th scales are displayed in a green state on the touch screen, and the 1 st, 7 th and 8 th scales are displayed in a red or gray state. The scale range corresponding to the green state can be operated, and the scale range corresponding to the red or gray state can not be operated.

In some optional embodiments, N scales are sequentially arranged on the preset circumferential path along a clockwise direction of the preset circumferential path, a difference between a set value of the target parameter corresponding to a kth scale and a set value of the target parameter corresponding to a (k-1) th scale is the same as a difference between a set value of the target parameter corresponding to a (k + 1) th scale and a set value of the target parameter corresponding to a kth scale, N is an integer greater than 2, and k is an integer greater than 1 and smaller than N. In some specific applications, the parameter values of the N scales may be displayed (by a controller of the programmable device) using a touch screen.

In a specific application, the target parameter is a voltage amplitude parameter, 255 scales are sequentially arranged on the preset circumferential path along the path direction of the sliding path, the difference value between the set values of the voltage amplitude parameter corresponding to two adjacent scales is a fixed value of 0.05V, and the set values of the voltage amplitude parameter corresponding to the 255 scales are sequentially 0.05V, 0.1V, 0.15V, 0.2V, 0.25V and 0.3V … … 12.75.75V.

Therefore, the N scales form an arithmetic progression corresponding to the set values of the calibration parameters, and the arithmetic progression conforms to the operation habits of users.

In some optional embodiments, the preset circumferential path is sequentially provided with N scales along a clockwise direction of the preset circumferential path, and a difference between a set value of a target parameter corresponding to a kth scale and a set value of a target parameter corresponding to a k-1 th scale is different from a difference between a set value of a target parameter corresponding to a (k + 1) th scale and a set value of a target parameter corresponding to a kth scale.

In a specific application, the target parameter is a voltage frequency parameter, the preset circumferential path is sequentially provided with 8 scales along the path direction of the sliding path, the difference value between the set values of the voltage frequency parameters corresponding to two adjacent scales is not a fixed value, and the set values of the voltage frequency parameters corresponding to the 8 scales are sequentially 20Hz, 60Hz, 100Hz, 200Hz, 210Hz, 230Hz, 240Hz and 245 Hz.

Therefore, the set value of the target parameter corresponding to any scale can be flexibly set according to the requirement of practical application, and the application range is wide.

In some optional embodiments, the preset circumferential path is sequentially provided with N scales along a clockwise direction of the preset circumferential path, and a difference between a set value of a target parameter corresponding to a kth scale and a set value of a target parameter corresponding to a k-1 th scale is smaller than a difference between a set value of a target parameter corresponding to a k +1 th scale and a set value of a target parameter corresponding to a kth scale.

Therefore, along the clockwise direction of the preset circumferential path, the difference value of the set values of the target parameters corresponding to the two adjacent scales is larger and larger, so that the amplitude change of the set value corresponding to the track point (corresponding to the scale) is faster gradually in the process of clockwise sliding of the user, and the setting efficiency of the parameter values is further improved.

Referring to fig. 10, in some optional embodiments, the method may further include step S208.

Step S208: and when the position of any one track point of the sliding path is detected not to be in the preset sliding area, no operation is performed, or the user is prompted to operate again, or the preset sliding area is displayed on the touch screen in a flashing state.

Therefore, when the position of any one track point of the sliding path is not in the preset sliding area, the sliding operation is possibly caused by the fact that the user mistakenly touches the sliding area, the sliding operation is judged to be invalid, at the moment, no operation can be performed, the user is indirectly prompted to be invalid in a non-reaction mode after the sliding operation, or the user is prompted to operate again, or the preset sliding area is displayed in a flashing state on the touch screen, through any one of the processing modes, the effect of prompting the user that the sliding operation is invalid at this time can be achieved, and the intelligent degree is high.

Referring to fig. 11, in some optional embodiments, the method may further include step S209.

Step S209: and when the similarity is smaller than the preset similarity threshold, no operation is performed, or a user is prompted to perform the operation again, or the preset circular path is displayed on the touch screen in a flashing state.

Therefore, when the similarity is smaller than the preset similarity threshold, the sliding operation is possibly caused by the fact that the user mistakenly touches the sliding operation, the sliding operation is judged to be invalid, at the moment, no operation can be performed, the user is indirectly prompted to be invalid in a non-response mode after the sliding operation, or the user is prompted to operate again, or a preset circular path is displayed on the touch screen in a flashing state, the user is prompted to be invalid in the sliding operation, and the intelligent degree is high.

Referring to fig. 12, the present application further provides a program control device 100, and a specific implementation manner of the program control device is consistent with the implementation manner and the achieved technical effect described in the embodiment of the control method, and details of the implementation manner and the achieved technical effect are not repeated.

The programming device 100 is applied to an implantable neurostimulation system, which comprises the programming device 100 arranged outside a patient body and a stimulator implanted in the patient body;

the programming device 100 is communicatively coupled with the stimulator, the programming device 100 comprising:

a touch screen 101, the touch screen 101 configured to receive an operation by a user;

a communication module 102, the communication module 102 configured to enable data interaction between the programming device 100 and the stimulator;

a controller 103, the controller 103 being electrically connected with the touch screen 101 and the communication module 102, respectively, the controller 103 being configured to:

receiving a sliding operation by using the touch screen 101, and responding to the sliding operation to obtain a configuration parameter value of a target parameter;

In some embodiments, the controller 103 may include at least one memory, at least one processor, and a bus connecting different platform systems. The memory may include one or more of Random Access Memory (RAM), Read Only Memory (ROM), and cache memory, among others. The memory stores a computer program that can be executed by the processor. The bus may be any of several types of bus structures including a memory bus, a peripheral bus, an accelerated graphics port, or a local bus using any of a variety of bus architectures.

In some optional embodiments, the controller 103 is further configured to obtain the configuration parameter value of the target parameter by:

acquiring the similarity of the sliding path and the reference path;

In some optional embodiments, the controller 103 is further configured to:

before detecting whether the positions of all track points of the sliding path are in the preset sliding area, detecting whether the starting point of the sliding path is in an effective starting point range, wherein the effective starting point range comprises position points on the touch screen 101 corresponding to the current parameter value of the target parameter;

if the starting point of the sliding path is not in the effective starting point range, no operation is performed, or the user is prompted to perform a new operation, or an area corresponding to the effective starting point range is displayed on the touch screen 101 in a flashing state.

In some optional embodiments, the controller 103 is further configured to obtain the reference path by:

In some optional embodiments, the controller 103 is further configured to obtain the similarity in the following manner:

In some optional embodiments, the controller 103 is further configured to obtain the preset similarity threshold value as follows:

In some optional embodiments, the preset circumferential path is provided with at least one scale, and the controller 103 is further configured to obtain the configuration parameter value of the target parameter by:

In some optional embodiments, the controller 103 obtains the measurement range of the target parameter corresponding to the preset circumferential path by:

acquiring a second corresponding relation between a configuration parameter value of an associated parameter and the measuring range of the target parameter corresponding to the preset circumferential path, wherein the associated parameter is one or more parameters except the target parameter in the parameters of the stimulator;

In some optional embodiments, the controller 103 is further configured to:

when the position of any one track point of the sliding path is detected not to be in the preset sliding area, no operation is performed, or the user is prompted to perform the operation again, or the preset sliding area is displayed on the touch screen 101 in a flashing state.

In some optional embodiments, the controller 103 is further configured to:

when the similarity is smaller than the preset similarity threshold, no operation is performed, or the user is prompted to perform a re-operation, or the preset circular path is displayed on the touch screen 101 in a flashing state.

Referring to fig. 13, the present application further provides an implantable neurostimulation system 300, and the specific implementation manner thereof is consistent with the implementation manner and the achieved technical effect described in the above embodiment of the control method, and details are not repeated.

The implantable neurostimulation system 300 comprises the programming device 100 disposed outside of a patient and a stimulator implanted within the patient;

From this, implanted neurostimulation system 300 of this application can support user's sliding operation, and the user can set up the parameter value through gliding mode, has significantly reduced user's operating procedure for the parameter value sets up more convenient fast, promotes user's use and experiences.

It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

When an element is referred to as being "on" or "on," "connected to" or "coupled to" another element, it can be directly on, connected or coupled to the other element or intervening elements may be present. However, when an element is referred to as being "directly on," "directly connected to" or "directly coupled to" another element, there are no intervening elements present. For purposes of this disclosure, the term "connected" may refer to physically, electrically, etc., and may or may not have intermediate components.

While the present application is described in terms of various aspects, including exemplary embodiments, the principles of the invention should not be limited to the disclosed embodiments, but are also intended to cover various modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Claims

1. A programming device for use in an implantable neurostimulation system, the implantable neurostimulation system comprising the programming device disposed outside a patient and a stimulator implanted in the patient;

a touch screen configured to receive an operation of a user;

2. The programmable device of claim 1, wherein the controller is further configured to obtain the configuration parameter value for the target parameter by:

acquiring the similarity of the sliding path and the reference path;

3. The programming device of claim 2, wherein the controller is further configured to:

4. The programming device of claim 2, wherein the controller is further configured to obtain the reference path by:

5. The programmable device of claim 2, wherein the controller is further configured to obtain the similarity by:

6. The programmable device of claim 2, wherein the controller is further configured to obtain the preset similarity threshold by:

7. The programmable device of claim 2, wherein the controller is further configured to obtain the configuration parameter value for the target parameter by:

8. The programmable device of claim 4, wherein the preset circumferential path is provided with at least one scale, the controller being further configured to obtain the configuration parameter value of the target parameter by:

9. The programming apparatus according to claim 7 or 8, wherein the controller obtains the measurement range of the target parameter corresponding to the preset circular path by:

10. The program-controlled device according to claim 8, wherein the preset circular path is sequentially provided with N scales along a clockwise direction thereof, a difference between a set value of the target parameter corresponding to a k-th scale and a set value of the target parameter corresponding to a k-1 th scale is smaller than a difference between a set value of the target parameter corresponding to a k +1 th scale and a set value of the target parameter corresponding to a k-th scale, N is an integer greater than 2, and k is an integer greater than 1 and smaller than N.

11. The programming device of claim 2, wherein the controller is further configured to:

12. The programming device of claim 2, wherein the controller is further configured to:

13. The programmable device according to claim 1, wherein the target parameter is any one of a pulse width parameter, an amplitude parameter and a frequency parameter of the voltage.

14. The programming device of claim 1, wherein the patient's disease type comprises one or more of epilepsy, tremor, parkinson's disease, depression, obsessive compulsive disorder, alzheimer's disease, and drug addiction.

15. An implantable neurostimulation system, comprising the programming device disposed outside a patient and a stimulator implanted in the patient;

a touch screen configured to receive an operation of a user;

receiving a sliding operation by using the touch screen, and responding to the sliding operation to obtain a configuration parameter value of the target parameter;