CN114271986A

CN114271986A - Fixing device for mouse periapical periodontitis model

Info

Publication number: CN114271986A
Application number: CN202111591487.1A
Authority: CN
Inventors: 郝亮; 李嘉鑫; 李津乐; 潘唯一; 岳源
Original assignee: Sichuan University
Current assignee: Sichuan University
Priority date: 2021-12-23
Filing date: 2021-12-23
Publication date: 2022-04-05
Anticipated expiration: 2041-12-23
Also published as: CN114271986B

Abstract

The invention discloses a fixing device for a mouse periapical periodontitis model, which comprises a base plate, a body fixing component and a tooth fixing component. According to the invention, the body of the mouse is fixed by arranging the body fixing component, so that the mouse is prevented from moving in the experiment process. The incisor teeth of the mouse are pulled and fixed by arranging the tooth fixing assembly, so that the mouth of the mouse is opened, and the preparation of the marrow opening shape of the teeth is facilitated. The four limbs of the mouse are fixed by arranging the limb fixing component, so that the whole experiment process can be further prevented from being carried out smoothly due to struggling and moving of the mouse in the experiment process. In addition, the upper body splint for clamping the trunk of the mouse is arranged as the expansion plate, so that the mouse with a larger body size can be fixed, and the practicability is enhanced. The invention solves the problem that an experimental model can not be successfully established because the head fixing and the tooth positioning can not be carried out after the mouse is anesthetized in the experiment.

Description

Fixing device for mouse periapical periodontitis model

Technical Field

The invention relates to the technical field of experimental equipment, in particular to a fixing device for a mouse periapical periodontitis model.

Background

Chronic periapical inflammation is a common and frequently encountered disease in the oral cavity, and is a chronic inflammatory reaction of periapical tissues caused by long-term infection and pathogenic stimulation in root canals, which is manifested by inflammatory granulation tissue formation and alveolar bone destruction. Because the human condition is limited, the dynamic process of histopathology of periapical periodontitis and the function of cytokines in the dynamic process cannot be directly researched in many cases, so that the selection and establishment of a proper animal model and the simulation of human intraoral conditions for relevant experimental research are the most common methods for clinical experiments. The experimental mouse is close to the relationship with human, and is the best experimental animal for multidisciplinary microscopic researches such as biology, pharmacology, pathology and the like.

The establishment of the periapical periodontitis model requires the preparation of the marrow opening of the first molar of the mouse under a stereomicroscope, the visual field of the stereomicroscope is small, and the magnification is high. Under the condition, if the head and the body of the mouse cannot be well fixed, the preparation of the open-marrow cavity shape can not be easily carried out, and the experimental model can not be successfully established. If the mouse has poor fixing effect, the preparation effect of the open-marrow cavity shape, which is a key step in the process of establishing the model, is obviously influenced. In addition, the mouth of the mouse needs to be opened while the head and the body of the mouse are fixed, so that molars in the oral cavity of the mouse are fully exposed, and the preparation of the tooth cavity is convenient.

Disclosure of Invention

The invention aims to provide a fixing device for a mouse periapical periodontitis model, which is used for fixing a mouse and expanding the mouth of the mouse, and solves the problem that an experimental model cannot be successfully established because the head of the mouse cannot be fixed and teeth cannot be positioned after the mouse is anesthetized in an experiment.

The invention provides a fixing device for a mouse periapical periodontitis model, which comprises a bottom plate;

the body fixing assembly comprises an operating plate fixedly arranged on the upper surface of a base plate, a first bidirectional screw fixedly connected with an output shaft of a first motor fixedly arranged on the base plate is arranged below the operating plate, first sliding sleeves in threaded connection with the first bidirectional screw are respectively sleeved at two ends of the first bidirectional screw, two parallel clamping plates are arranged above the operating plate, the cross section contour line of each clamping plate is the same as the shape of an outer contour line on one side of a mouse body, a through groove positioned right above the first bidirectional screw is formed in the operating plate, and two first sliding blocks respectively penetrate through the through groove to be fixedly connected with the two clamping plates;

the tooth fixing assembly comprises a second bidirectional lead screw fixedly connected with an output shaft of a second motor fixedly installed on the bottom plate, the second bidirectional lead screw is perpendicular to the first bidirectional lead screw, two ends of the second bidirectional lead screw are respectively sleeved with a second sliding sleeve in threaded connection with the second bidirectional lead screw, the lower part of the second sliding sleeve is fixedly connected with a convex block in sliding connection with a T-shaped sliding groove on the bottom plate, a telescopic rod is arranged between the two second sliding blocks, one end of the telescopic rod is rotatably connected with one of the second sliding blocks, and the other end of the telescopic rod is fixedly connected with an output shaft of a third motor fixedly installed on the other second sliding block;

two be equipped with the last pull ring that is used for fixed mouse upper portion tooth between the splint for the pull-down ring of fixed mouse lower part tooth, go up pull ring, pull-down ring respectively through dwang and telescopic link fixed connection.

Preferably, splint include fixed connection's head splint, neck splint, upper part of the body splint, lower part of the body splint in proper order, the cross section contour line of head splint be convex and the same with the shape of the outer contour line of mouse one side head, the cross section contour line of neck splint be convex and the same with the shape of the outer contour line of mouse one side neck, the cross section contour line of upper part of the body splint is the straight line shape, the cross section contour line of lower part of the body splint be convex and the same with the shape of mouse one side lower part of the body outer contour line.

Preferably, the bottom plate is provided with a limb fixing assembly, the limb fixing assembly comprises four fixing seats respectively arranged at the front end and the rear end of the side, away from each other, of the two clamping plates, and the four fixing seats are respectively in sliding connection with sliding grooves arranged on the operating plate; two offer the preceding through-hole that is used for making the forelimb of mouse to pass on the splint of upper part of the body respectively, two offer the back through-hole that is used for making the hind limb of mouse to pass on the splint of lower part of the body respectively, the both sides of preceding through-hole are fixed respectively and are equipped with one end and fixing base fixed connection's spring, the both sides of back through-hole are fixed respectively and are equipped with one end and fixing base fixed connection's spring, the fixed rubber circle that is equipped with in top of fixing base, wear to be equipped with on the fixing base and be used for with spout fixed connection's holding bolt.

Preferably, the upper body splint is a telescopic plate.

Preferably, a head cushion is arranged between the two head clamping plates, an arc groove is formed in the head cushion, and the head cushion is a spongy cushion.

Preferably, two the fixed head fixed band that is equipped with respectively on the head splint, two the fixed neck fixed band that is equipped with respectively on the neck splint, two fixed body fixed band that is equipped with respectively on the upper part of the body splint, head fixed band, neck fixed band, body fixed band are primary and secondary buckle fixed band respectively.

Preferably, a controller is arranged on the bottom plate, and the controller is electrically connected with the first motor, the second motor and the third motor respectively.

Preferably, a support frame for mounting the operating panel is fixedly arranged on the upper surface of the bottom plate, and one end of the first bidirectional screw rod is rotatably connected with the support frame.

Preferably, one end of the second bidirectional screw is rotatably connected with a support seat fixedly installed on the bottom plate.

Preferably, the dwang passes through connecting rod and drop-down ring fixed connection, the connecting rod is mutually perpendicular with the dwang, the length of connecting rod is greater than the length of splint.

Compared with the prior art, the invention has the beneficial effects that:

according to the invention, the body of the mouse is fixed by arranging the body fixing component, so that the body and the head of the mouse are prevented from shaking in the experiment process. The teeth of the mouse are pulled and fixed by arranging the tooth fixing assembly, so that the mouth of the mouse is opened, and the preparation of the tooth opening marrow hole shape is facilitated. The four limbs of the mouse are fixed by arranging the limb fixing component, so that the whole experiment process can be further prevented from being carried out smoothly due to struggling and moving of the mouse in the experiment process. In addition, the upper body splint for clamping the trunk of the mouse is arranged as the expansion plate, so that the mouse with a larger body size can be fixed, and the practicability is enhanced. The invention realizes the fixation of the mouse, can open the mouth of the mouse and solves the problem that the experimental model can not be successfully established because the mouse struggles in the experiment.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic top view of a fixing device for a mouse periapical periodontitis model according to the present invention;

FIG. 2 is a schematic side view of a partial structure of a fixing device for a mouse periapical periodontitis model according to the present invention;

FIG. 3 is a schematic side view of a partial structure of a fixing device for a mouse periapical periodontitis model according to the present invention;

FIG. 4 is a schematic top view of a partial structure of a fixing device for a mouse periapical periodontitis model according to the present invention;

FIG. 5 is a schematic side view of a partial structure of a fixing device for a mouse periapical periodontitis model according to the present invention;

FIG. 6 is a schematic top view showing a partial structure of a fixing device for a mouse periapical periodontitis model according to the present invention.

Description of reference numerals:

1-base plate, 2-body fixation assembly, 3-teeth fixation assembly, 4-limbs fixation assembly, 5-headrest, 6-head fixation strap, 7-neck fixation strap, 8-body fixation strap, 9-controller, 10-support bracket, 11-support base, 12-connecting rod, 101-T chute, 201-operation plate, 202-first motor, 203-first bidirectional screw, 204-first sliding sleeve, 205-splint, 206-through slot, 301-second bidirectional screw, 302-second sliding sleeve, 303-telescopic rod, 304-second motor, 305-third motor, 306-upper pull ring, 307-lower pull ring, 308-rotary rod, 309-lug, 401-fixation base, 402-spring, 403-rubber ring, 404-fastening bolt, 501-arc groove, 2011-sliding groove, 2051-head splint, 2052-neck splint, 2053-upper body splint, 2054-lower body splint, 20531-front through hole and 20541-rear through hole.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to the drawings in the embodiments of the present invention, but it should be understood that the scope of the present invention is not limited by the specific embodiments.

Examples

As shown in fig. 1 to 6, a fixing device for a mouse periapical periodontitis model comprises a base plate 1, a body fixing component 2 and a tooth fixing component 3, wherein when the fixing device for the mouse periapical periodontitis model is used, the body of a mouse is fixed by the body fixing component 2, the mouse is prevented from moving, and teeth of the mouse are pulled and fixed by the tooth fixing component 3, so that the mouth of the mouse is opened, and the preparation of the open-pith hole shape of the teeth is facilitated.

The body fixing component 2 comprises an operation board 201 fixed on the upper surface of the bottom board 1, a first bidirectional screw 203 fixedly connected with an output shaft of a first motor 202 fixedly installed on the bottom board 1 is arranged below the operation board 201, a first sliding sleeve 204 in threaded connection with the first bidirectional screw 203 is respectively sleeved on two ends of the first bidirectional screw 203, two parallel clamping plates 205 are arranged above the operation board 201, a through groove 206 positioned right above the first bidirectional screw 203 is arranged on the operation board 201, when in use, the first motor 202 is controlled to rotate to drive the first bidirectional screw 203 to rotate, as the two first sliding sleeves 204 respectively pass through the through groove 206 and are fixedly connected with the two clamping plates 205, when the first bidirectional screw 203 rotates, the through groove 206 can limit the two first sliding sleeves 204 sleeved on the first bidirectional screw 203 to rotate, so that when the first motor 202 drives the first bidirectional screw 203 to rotate forward and backward, the two first sliding sleeves 204 move toward or away from each other relative to the first bidirectional screw 203, so that the two clamping plates 205 fixedly connected with the first sliding sleeves 204 move toward or away from each other. When the two clamping plates 205 are close to each other, the mouse placed between the two clamping plates 205 can be clamped, the mouse can be prevented from escaping, and when the two clamping plates 205 are far away from each other, the clamped mouse can be released. By setting the shape of the cross-sectional contour of the clamping plate 205 to be the same as the outer contour of the mouse body, the contour of the space formed when the two clamping plates 205 are brought close to each other is approximated to the outer contour of the mouse body, which is more advantageous for stably fixing the mouse between the two clamping plates 205 when the two clamping plates 205 are brought close to each other.

The tooth fixing component 3 comprises a second bidirectional screw 301 which is perpendicular to the first bidirectional screw 203 and is fixedly connected with an output shaft of a second motor 304 fixedly installed on the bottom plate 1, two ends of the second bidirectional screw 301 are respectively sleeved with a second sliding sleeve 302 in threaded connection with the second bidirectional screw 301, an expansion link 303 is arranged between the two second sliding blocks 302, one end of the expansion link 303 is rotatably connected with one of the second sliding sleeves 302, the other end of the expansion link 303 is fixedly connected with an output shaft of a third motor 305 fixedly installed on the other second sliding sleeve 302, an upper pull ring 306 for fixing upper teeth of a mouse is arranged between the two clamping plates 205, a lower pull ring 307 for fixing lower teeth of the mouse is arranged, the upper pull ring 306 and the lower pull ring 307 are respectively and fixedly connected with the expansion link through a rotating rod 308, and the second bidirectional screw 301 is driven to rotate forward and backward by driving the second motor 304 to rotate forward and backward, because the lower part of the second sliding sleeve 302 is fixedly connected with a projection 309 which is connected with the T-shaped chute 101 on the bottom plate 1 in a sliding way, when the second bidirectional lead screw 301 rotates in the forward and reverse directions, the protrusion 309 slidably connected to the T-shaped sliding groove 101 can limit the second sliding sleeve 302 to rotate, so as to enable the two second sliding sleeves 302 to move toward or away from each other with respect to the second bidirectional lead screw 301, first control the second motor 304 to rotate in the forward direction to enable the two second sliding sleeves 302 to move toward each other, the telescopic bar 303 is compressed and the upper pulling ring 306 and the lower pulling ring 307 approach each other, and at this time, the upper teeth of the mouse are sleeved by the upper pull ring 306, the lower teeth of the mouse are sleeved by the lower pull ring 307, and then the second motor 304 is controlled to rotate reversely to make the two second sliding sleeves 302 move away from each other, the telescopic rod 303 is stretched, the upper pulling ring 306 and the lower pulling ring 307 move away from each other, the mouth of the mouse is spread, so that the preparation of the tooth pulp opening shape of the teeth of the mouse can be realized.

Rotate through controlling third motor 305, can make fixed connection take place to rotate with pull ring 307 on last pull ring 306 on telescopic link 303, after the completion is fixed the mouse, control third motor 305 forward rotation will go up pull ring 306 and pull ring 307 and rotate the top of the oral area of mouse respectively down, after the experiment, control third motor 305 counter rotation, make one side that operation panel 201 was kept away from to go up pull ring 306 and pull ring 307 down, avoid, it forms the hindrance with pull ring 307 down to avoid going up pull ring 306, be unfavorable for the subsequent processing operation.

Dwang 308 passes through connecting rod 12 and drop link 307 fixed connection, and connecting rod 12 is perpendicular mutually with dwang 308, and the length of connecting rod 12 is greater than splint 205's length, realizes making dwang 308 drive from one side of splint 205 tip down pull ring 307 rotate mouse oral area top, avoids forming the hindrance because of splint 205 rotation to dwang 308 when too high.

The clamp plate 205 includes a head clamp plate 2051, a neck clamp plate 2052, an upper body clamp plate 2053, and a lower body clamp plate 2054 which are fixedly connected in sequence, a cross-sectional contour line of the head clamp plate 2051 is arc-shaped and is the same as the shape of the outer contour line of the head on one side of the mouse, a cross-sectional contour line of the neck clamp plate 2052 is arc-shaped and is the same as the shape of the outer contour line of the neck on one side of the mouse, a cross-sectional contour line of the upper body clamp plate 2053 is straight, and a cross-sectional contour line of the lower body clamp plate 2054 is arc-shaped and is the same as the shape of the outer contour line of the lower body on one side of the mouse, so that the cross-sectional contour line of the clamp plate 205 is more attached to the body contour line of the mouse, and the two clamp plates 205 are favorable for firmly clamping the mouse.

Be equipped with the fixed subassembly 4 of limbs on bottom plate 1, the fixed subassembly 4 of limbs is including establishing four fixing bases 401 at two splint 205 front and back ends that deviate from each other respectively, four fixing bases 401 respectively with the spout 2011 sliding connection that is equipped with on the operation panel 201, offer the preceding through-hole 20531 that is used for making the forelimb of mouse to pass on two upper part splint 2053 respectively, offer the back through-hole 20541 that is used for making the hindlimb of mouse to pass on two lower part splint 2054 respectively, the both sides of preceding through-hole 20531 are fixed respectively and are equipped with one end and fixing base 401 fixed connection's spring 402, the both sides of back through-hole 20541 are fixed respectively and are equipped with one end and fixing base 401 fixed connection's spring 402, the fixed rubber ring 403 that is equipped with in top of fixing base 401, wear to be equipped with on the fixing base 401 and be used for the holding bolt 404 with spout 2011 fixed connection.

Two forelimbs of the mouse to be placed between two splint 205 are respectively drawn out from two front through holes 20531, two hind limbs are respectively worn out from two rear through holes 20541, two forelimbs and two hind limbs are respectively fastened and fixed by rubber rings 404 on four fixing seats 401, so that all limbs of the mouse are fixed, when the trunk of the mouse is too long, the fastening bolt 404 can be unscrewed, the fixing seats 401 are controlled to move in the direction away from the splint 205, the fixing seats 401 slide in the sliding grooves 2011, and when the fixing seats 401 are moved to a proper position, the fastening bolt 404 is screwed again to fix the trunk of the mouse.

The upper part of the body splint 2053 is the expansion plate, and when the size of the mouse that tests is great long, the upper part of the body splint 2053 can be extended, so that the mouse with the large size can be clamped and fixed, and in practical application, the first sliding sleeve 204 and the non-expansion end of the upper part of the body splint 2053 can be fixedly connected.

Be equipped with headrest 5 between two head splint 2051, offered arc groove 501 on headrest 5, in order to heighten the head pad of mouse, be convenient for carry out the test operation to mouse oral cavity inside, headrest 5 is the foam-rubber cushion, and when two head splint 2051 were close to each other, the headrest 5 of sponge material was compressed, can avoid headrest 5 to obstruct the motion of being close to each other of two head splint 2051.

The fixed head fixed band 6 that is equipped with respectively on two head splint 2051, the fixed neck fixed band 7 that is equipped with respectively on two neck splint 2052, the fixed body fixed band 8 that is equipped with respectively on two upper part of the body splint 2053, head fixed band 6, neck fixed band 7, body fixed band 8 are primary and secondary buckle fixed band respectively, fix for the head of further mouse, neck, truck, avoid taking place the drunkenness because of the mouse, and make whole experimentation accomplish smoothly.

The controller 9 is arranged on the bottom plate 1, the controller 9 is electrically connected with the first motor 202, the second motor 304 and the third motor 305 respectively, and the controller 9 is used for controlling all electric devices, so that the operation is more convenient and faster.

The fixed support frame 10 that is used for installing operation panel 201 that is equipped with of bottom plate 1's upper surface has realized the fixed mounting of operation panel 201, and the one end and the support frame 10 of first bidirectional screw 203 rotate to be connected, rotate first bidirectional screw 203 with the one end of first motor 202 fixed connection with support frame 10 and be connected, can avoid first bidirectional screw 203 to appear rocking when rotating.

One end of the second bidirectional screw 301 is rotatably connected to the support base 11 fixedly mounted on the bottom plate 1, so as to avoid the second bidirectional screw 301 from shaking during rotation.

The working principle and the using process of the invention are as follows: when the mouse fixing device is used, a mouse is placed between the two clamping plates 205, the controller 9 is used for controlling the first motor 202 to rotate to drive the first bidirectional screw 203 to rotate, the two first sliding sleeves 204 move close to or away from each other relative to the first bidirectional screw 203, and therefore the two clamping plates 205 fixedly connected with the first sliding sleeves 204 move close to or away from each other, and the mouse is stably fixed between the two clamping plates 205.

And the head fixing band 6, the neck fixing band 7 and the body fixing band 8 are utilized to further fix the head, the neck and the trunk of the mouse, so that the phenomenon that the whole experiment process cannot be smoothly finished due to the play of the mouse is avoided.

The controller 9 is used for controlling the third motor 305 to rotate forward to rotate the upper pull ring 306 and the lower pull ring 307 to the upper part of the mouth of the mouse respectively, then the second motor 304 is controlled to rotate forward to enable the two second sliding sleeves 302 to be close to each other, then the telescopic rod 303 is compressed, then the upper pull ring 306 and the lower pull ring 307 are close to each other, at the moment, the upper pull ring 306 is used for sheathing the upper teeth of the mouse, the lower pull ring 307 is used for sheathing the lower teeth of the mouse, then the second motor 304 is controlled to rotate reversely to enable the two second sliding sleeves 302 to be far away from each other, then the telescopic rod 303 is stretched and extended, then the upper pull ring 306 and the lower pull ring 307 are far away from each other, then the mouth of the mouse is stretched, and therefore the tooth pulp opening shape of the teeth of the mouse can be prepared.

Finally, the description is as follows: the above disclosure is only one specific embodiment of the present invention, however, the present invention is not limited thereto, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.

Claims

1. A fixing device for a mouse periapical periodontitis model, comprising:

a base plate (1);

the body fixing assembly (2) comprises an operating plate (201) fixedly arranged on the upper surface of the bottom plate (1), a first bidirectional screw (203) fixedly connected with an output shaft of a first motor (202) fixedly arranged on the bottom plate (1) is arranged below the operating plate (201), and two ends of the first bidirectional screw (203) are respectively sleeved with a first sliding sleeve (204) in threaded connection with the first bidirectional screw (203);

two parallel clamping plates (205) are arranged above the operating plate (201), the cross section contour line of each clamping plate (205) is the same as the shape of the outer contour line of one side of the mouse body, a through groove (206) which is positioned right above the first bidirectional screw (203) is formed in the operating plate (201), and the two first sliding blocks (204) respectively penetrate through the through groove (206) to be fixedly connected with the two clamping plates (205);

a tooth fixing component (3) which comprises a second bidirectional screw rod (301) fixedly connected with an output shaft of a second motor (304) fixedly arranged on the bottom plate (1), the second bidirectional screw (301) is perpendicular to the first bidirectional screw (203), a second sliding sleeve (302) in threaded connection with the second bidirectional screw (301) is respectively sleeved at two ends of the second bidirectional screw (301), the lower part of the second sliding sleeve (302) is fixedly connected with a convex block (309) which is connected with a T-shaped sliding groove (101) on the bottom plate (1) in a sliding way, a telescopic rod (303) is arranged between the two second sliding blocks (302), one end of the telescopic rod (303) is rotationally connected with one of the second sliding blocks (302), the other end of the telescopic rod (303) is fixedly connected with an output shaft of a third motor (305) fixedly arranged on the other second sliding block (302);

two be equipped with between splint (205) and be used for fixed mouse upper portion tooth last pull ring (306) for fixed mouse lower part tooth lower pull ring (307), last pull ring (306), lower pull ring (307) are respectively through dwang (308) and telescopic link (303) fixed connection.

2. The fixing device for the periapical periodontitis model of mouse according to claim 1, wherein: the clamp plate (205) comprises a head clamp plate (2051), a neck clamp plate (2052), an upper body clamp plate (2053) and a lower body clamp plate (2054) which are fixedly connected in sequence;

the cross section contour line of head splint (2051) is arc and the same with the shape of the outer contour line of mouse one side head, the cross section contour line of neck splint (2052) is arc and the same with the shape of the outer contour line of mouse one side neck, the cross section contour line of upper part of the body splint (2053) is the straight line shape, the cross section contour line of lower part of the body splint (2054) is arc and the same with the shape of the outer contour line of mouse one side lower half of the body.

3. The fixing device for the periapical periodontitis model of mouse according to claim 2, wherein:

the bottom plate (1) is provided with a limb fixing component (4);

the limb fixing component (4) comprises four fixing seats (401) which are respectively arranged at the front end and the rear end of the side, away from each other, of the two clamping plates (205), and the four fixing seats (401) are respectively in sliding connection with sliding grooves (2011) arranged on the operating plate (201);

front through holes (20531) for leading limbs of a mouse to pass through are respectively formed in the two upper body splints (2053), rear through holes (20541) for leading the rear limbs of the mouse to pass through are respectively formed in the two lower body splints (2054), springs (402) with one ends fixedly connected with the fixing seats (401) are respectively fixedly arranged on two sides of the front through holes (20531), and springs (402) with one ends fixedly connected with the fixing seats (401) are respectively fixedly arranged on two sides of the rear through holes (20541);

the fixed rubber circle (403) that is equipped with in top of fixing base (401), wear to be equipped with on fixing base (401) and be used for with spout (2011) fixed connection's holding bolt (404).

4. The fixing device for the periapical periodontitis model of mouse according to claim 2, wherein: the upper body splint (2053) is a telescopic plate.

5. The fixing device for the periapical periodontitis model of mouse according to claim 2, wherein: a head cushion (5) is arranged between the two head clamping plates (2051), an arc groove (501) is formed in the head cushion (5), and the head cushion (5) is a spongy cushion.

6. The fixing device for the periapical periodontitis model of mouse according to claim 2, wherein: two fixed head fixed band (6) that are equipped with respectively on head splint (2051), two fixed neck fixed band (7) that are equipped with respectively on neck splint (2052), two fixed body fixed band (8) that are equipped with respectively on upper part of the body splint (2053), head fixed band (6), neck fixed band (7), body fixed band (8) are primary and secondary buckle fixed band respectively.

7. The fixing device for the periapical periodontitis model of mouse according to claim 1, wherein: the motor is characterized in that a controller (9) is arranged on the bottom plate (1), and the controller (9) is electrically connected with the first motor (202), the second motor (304) and the third motor (305) respectively.

8. The fixing device for the periapical periodontitis model of mouse according to claim 1, wherein: the upper surface of bottom plate (1) is fixed and is equipped with support frame (10) that are used for installing operation panel (201), the one end and the support frame (10) of first bidirectional screw (203) are rotated and are connected.

9. The fixing device for the periapical periodontitis model of mouse according to claim 1, wherein: one end of the second bidirectional screw rod (301) is rotatably connected with a supporting seat (11) fixedly installed on the bottom plate (1).

10. The fixing device for the periapical periodontitis model of mouse according to claim 1, wherein: dwang (308) are through connecting rod (12) and pull-down ring (307) fixed connection, connecting rod (12) are mutually perpendicular with dwang (308), the length of connecting rod (12) is greater than the length of splint (205).