CN114269904A - 由RAG失活的iPSC产生T细胞 - Google Patents

由RAG失活的iPSC产生T细胞 Download PDF

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CN114269904A
CN114269904A CN202080059218.8A CN202080059218A CN114269904A CN 114269904 A CN114269904 A CN 114269904A CN 202080059218 A CN202080059218 A CN 202080059218A CN 114269904 A CN114269904 A CN 114269904A
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cells
cell
population
tcr
medium
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L·J·巴克
L·卡朋特
A·西德韦
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Adaptimmune Ltd
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Adaptimmune Ltd
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CN202080059218.8A 2019-08-20 2020-08-20 由RAG失活的iPSC产生T细胞 Pending CN114269904A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1911953.6 2019-08-20
GBGB1911953.6A GB201911953D0 (en) 2019-08-20 2019-08-20 T cell production fram RAG inacivated iPSCs
PCT/EP2020/073400 WO2021032852A1 (en) 2019-08-20 2020-08-20 T cell production from rag inactivated ipscs

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CN114269904A true CN114269904A (zh) 2022-04-01

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CN202080059218.8A Pending CN114269904A (zh) 2019-08-20 2020-08-20 由RAG失活的iPSC产生T细胞

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US (1) US20220275332A1 (https=)
EP (1) EP4017968A1 (https=)
JP (1) JP2022545078A (https=)
KR (1) KR20220044844A (https=)
CN (1) CN114269904A (https=)
AU (1) AU2020334258A1 (https=)
BR (1) BR112022003093A2 (https=)
CA (1) CA3150429A1 (https=)
GB (1) GB201911953D0 (https=)
IL (1) IL290604A (https=)
MX (1) MX2022001959A (https=)
WO (1) WO2021032852A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114341349A (zh) * 2019-08-20 2022-04-12 艾达普特免疫有限公司 造血诱导培养基

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202006903D0 (en) * 2020-05-11 2020-06-24 Adaptimmune Ltd Modified iPSCs
GB202111169D0 (en) * 2021-08-03 2021-09-15 Adaptimmune Ltd Methods of T cell production
CN114517176B (zh) * 2022-01-27 2022-12-02 广东普罗凯融生物医药科技有限公司 一种将ips细胞诱导成nk细胞的试剂盒及其应用方法
GB202205572D0 (en) 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
GB202208545D0 (en) 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
GB202318950D0 (en) 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells
CN118421559B (zh) * 2024-07-04 2024-09-27 成都赛济元生物医药有限公司 定向分化淋巴造血前体细胞的小分子组合、试剂盒及方法

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WO2012061075A2 (en) * 2010-10-25 2012-05-10 The Regents Of The University Of California Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells
WO2017078807A1 (en) * 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
EP3170897A1 (en) * 2014-07-18 2017-05-24 Kyoto University Method for inducing t cells for immunocytotherapy from pluripotent stem cells
US9938499B2 (en) * 2013-03-13 2018-04-10 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
US20220275335A1 (en) * 2019-08-20 2022-09-01 Adaptimmune Limited Culture medium for haematopoietic induction

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JP2019080491A (ja) * 2016-03-16 2019-05-30 国立大学法人京都大学 免疫細胞療法用ｎｙ−ｅｓｏ１抗原特異的ｔ細胞の誘導方法
CN112534044A (zh) * 2018-02-16 2021-03-19 凯德药业股份有限公司 经修饰的多能干细胞及制备和使用方法

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WO2012061075A2 (en) * 2010-10-25 2012-05-10 The Regents Of The University Of California Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells
US9938499B2 (en) * 2013-03-13 2018-04-10 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
EP3170897A1 (en) * 2014-07-18 2017-05-24 Kyoto University Method for inducing t cells for immunocytotherapy from pluripotent stem cells
WO2017078807A1 (en) * 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CN108473961A (zh) * 2015-11-04 2018-08-31 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
US20220275335A1 (en) * 2019-08-20 2022-09-01 Adaptimmune Limited Culture medium for haematopoietic induction

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PATRICK M BRAUER等: "Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies", 《BLOOD》, vol. 128, no. 6, 14 May 2016 (2016-05-14), pages 783 - 793, XP086685951, DOI: 10.1182/blood-2015-10-676304 *
姚新生: "监测人TCRαβT细胞CDR3谱系漂移、TCR基因重排方法的建立和初步应用", 《中国博士学位论文全文数据库（电子期刊）医药卫生科技辑》, no. 2007, 15 January 2007 (2007-01-15), pages 059 - 62 *
窦肇华等: "《免疫细胞学与疾病》", 30 September 2004, 北京：中国医药科技出版社, pages: 16 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114341349A (zh) * 2019-08-20 2022-04-12 艾达普特免疫有限公司 造血诱导培养基

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JP2022545078A (ja) 2022-10-25
KR20220044844A (ko) 2022-04-11
MX2022001959A (es) 2022-03-11
GB201911953D0 (en) 2019-10-02
US20220275332A1 (en) 2022-09-01
CA3150429A1 (en) 2021-02-25
AU2020334258A1 (en) 2022-03-24
BR112022003093A2 (pt) 2022-05-17
EP4017968A1 (en) 2022-06-29
WO2021032852A1 (en) 2021-02-25
IL290604A (en) 2022-04-01

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