CN114262266A - Preparation method of anhydrous calcium lactate particles - Google Patents
Preparation method of anhydrous calcium lactate particles Download PDFInfo
- Publication number
- CN114262266A CN114262266A CN202210033053.8A CN202210033053A CN114262266A CN 114262266 A CN114262266 A CN 114262266A CN 202210033053 A CN202210033053 A CN 202210033053A CN 114262266 A CN114262266 A CN 114262266A
- Authority
- CN
- China
- Prior art keywords
- calcium lactate
- anhydrous calcium
- lactic acid
- preparation
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 title claims abstract description 59
- 239000001527 calcium lactate Substances 0.000 title claims abstract description 59
- 229960002401 calcium lactate Drugs 0.000 title claims abstract description 59
- 235000011086 calcium lactate Nutrition 0.000 title claims abstract description 59
- 239000002245 particle Substances 0.000 title abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 50
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 25
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 25
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 25
- 239000004310 lactic acid Substances 0.000 claims abstract description 25
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 239000000725 suspension Substances 0.000 claims abstract description 20
- 238000001694 spray drying Methods 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 239000011859 microparticle Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 5
- 239000010419 fine particle Substances 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 2
- 229960005069 calcium Drugs 0.000 abstract description 2
- 229910052791 calcium Inorganic materials 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 abstract description 2
- 238000002425 crystallisation Methods 0.000 abstract description 2
- 230000008025 crystallization Effects 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000005303 weighing Methods 0.000 description 7
- 238000001556 precipitation Methods 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 229940069978 calcium supplement Drugs 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to the technical field of anhydrous calcium lactate preparation, and discloses a preparation method of anhydrous calcium lactate particles, aiming at solving the problem of low efficiency of the traditional production process in the preparation of the anhydrous calcium lactate particles, which comprises the following steps: mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying calcium lactate solution to obtain anhydrous calcium lactate microparticles. The preparation method of the invention does not need the step of calcium lactate crystallization in the traditional production process, greatly shortens the time of industrial production of the anhydrous calcium lactate particles, and can greatly improve the content of free calcium in the calcium lactate product.
Description
Technical Field
The invention relates to the technical field of anhydrous calcium lactate preparation, in particular to a preparation method of anhydrous calcium lactate particles.
Background
Calcium lactate is an organic compound, is commonly used as a calcium supplement, has the effects of promoting the calcification formation of bones and teeth, maintaining the normal excitability of nerves and muscles, reducing capillary permeability and the like, and is generally only used for oral administration due to its low solubility. The traditional process of the existing anhydrous calcium lactate particles needs to wait for the precipitation of calcium lactate crystals in the preparation process, and has the problems of long time consumption and low efficiency.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a preparation method of anhydrous calcium lactate particles.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method for preparing anhydrous calcium lactate microparticles, comprising the following steps:
step 1: mixing calcium hydroxide with water to obtain a suspension for later use;
step 2: mixing the suspension with lactic acid to react to obtain calcium lactate solution;
and step 3: spray drying calcium lactate solution to obtain anhydrous calcium lactate microparticles.
Preferably, the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: (4-6): (9-11).
Preferably, the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 4: 9.
preferably, the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 6: 11.
preferably, the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 5: 10.
preferably, the concentration of the calcium lactate solution obtained in step 2 is 35%.
Preferably, the spray drying in step 3 comprises the following steps: the calcium lactate solution was atomized in a drying chamber.
Preferably, the temperature range in the drying chamber is 30-300 ℃.
The invention has the beneficial effects that:
the preparation method of the invention does not need the step of calcium lactate crystallization precipitation in the traditional production process, greatly shortens the time of industrial production of the anhydrous calcium lactate particles, improves the preparation efficiency of the anhydrous calcium lactate particles, and can greatly improve the content of free calcium in the calcium lactate product.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example 1
Weighing 2kg of calcium hydroxide, 5kg of lactic acid and 10kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 2
Weighing 2kg of calcium hydroxide, 4kg of lactic acid and 9kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 3
Weighing 2kg of calcium hydroxide, 6kg of lactic acid and 11kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 4
Weighing 2kg of calcium hydroxide, 4.5kg of lactic acid and 9.5kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 5
Weighing 2kg of calcium hydroxide, 5.5kg of lactic acid and 10.5kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 6
Weighing 2kg of calcium hydroxide, 4.5kg of lactic acid and 10.5kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
Example 7
Weighing 2kg of calcium hydroxide, 5.5kg of lactic acid and 9.5kg of water; mixing calcium hydroxide with water to obtain a suspension for later use; mixing the suspension with lactic acid to react to obtain calcium lactate solution; spray drying the calcium lactate solution in a drying chamber at the temperature of 30-300 ℃ to obtain the anhydrous calcium lactate particles.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A method for producing anhydrous calcium lactate fine particles, comprising the steps of:
step 1: mixing calcium hydroxide with water to obtain a suspension for later use;
step 2: mixing the suspension with lactic acid to react to obtain calcium lactate solution;
and step 3: spray drying calcium lactate solution to obtain anhydrous calcium lactate microparticles.
2. The method for producing anhydrous calcium lactate fine particles according to claim 1, wherein the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: (4-6): (9-11).
3. The method for producing anhydrous calcium lactate fine particles according to claim 1, wherein the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 4: 9.
4. the method for producing anhydrous calcium lactate fine particles according to claim 1, wherein the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 6: 11.
5. the method for producing anhydrous calcium lactate fine particles according to claim 1, wherein the weight ratio of the calcium hydroxide to the lactic acid to the water is 2: 5: 10.
6. the method of claim 1, wherein the concentration of the calcium lactate solution obtained in step 2 is 35%.
7. The method for preparing anhydrous calcium lactate fine particles according to claim 1, wherein the spray drying in step 3 comprises the following steps: the calcium lactate solution was atomized in a drying chamber.
8. The method according to claim 7, wherein the temperature in the drying chamber is in the range of 30 to 300 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210033053.8A CN114262266A (en) | 2022-01-12 | 2022-01-12 | Preparation method of anhydrous calcium lactate particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210033053.8A CN114262266A (en) | 2022-01-12 | 2022-01-12 | Preparation method of anhydrous calcium lactate particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114262266A true CN114262266A (en) | 2022-04-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210033053.8A Pending CN114262266A (en) | 2022-01-12 | 2022-01-12 | Preparation method of anhydrous calcium lactate particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114262266A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071757A1 (en) * | 2006-12-14 | 2008-06-19 | Purac Biochem Bv | Particulate composition comprising calcium lactate and calcium citrate microparticles |
| CN104661539A (en) * | 2012-08-01 | 2015-05-27 | 普拉克生物化学有限公司 | Lactate powder and method for the preparation thereof |
| CN109160877A (en) * | 2018-10-09 | 2019-01-08 | 武汉三江航天固德生物科技有限公司 | The production method of medical calcium lactate |
-
2022
- 2022-01-12 CN CN202210033053.8A patent/CN114262266A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071757A1 (en) * | 2006-12-14 | 2008-06-19 | Purac Biochem Bv | Particulate composition comprising calcium lactate and calcium citrate microparticles |
| CN101616600A (en) * | 2006-12-14 | 2009-12-30 | 普拉克生化公司 | The particle that comprises calcium lactate and calcium citrate microparticles |
| CN104661539A (en) * | 2012-08-01 | 2015-05-27 | 普拉克生物化学有限公司 | Lactate powder and method for the preparation thereof |
| CN109160877A (en) * | 2018-10-09 | 2019-01-08 | 武汉三江航天固德生物科技有限公司 | The production method of medical calcium lactate |
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Application publication date: 20220401 |
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| RJ01 | Rejection of invention patent application after publication |