CN114259632A - Push-and-turn storage type aerosol powder device - Google Patents

Abstract

A push-and-twist type storage type aerosol powder device, which belongs to the field of medical appliances. Comprises a suction nozzle, an upper shell, an upper middle shell, a lower middle shell and a bottom shell which are arranged in sequence; the upper shell is provided with a device air inlet; a push button is arranged on the middle upper shell; a medicine storage barrel, a medicine pit plate, a spring, a lower rail, an upper rail, a cover plate, a device runner and a connecting rod are arranged in the upper shell and the upper middle shell; a first ratchet wheel and a second ratchet wheel are arranged in the middle lower shell; a gear cover plate, a transition gear and a counting gear are arranged in the bottom shell; the upper shell and the upper middle shell are coaxially arranged; the medicine pit plate, the spring, the lower rail, the upper rail, the cover plate, the gear cover plate, the first ratchet wheel, the second ratchet wheel, the counting gear and the connecting rod are coaxially arranged; the push-twist structure design is added in the integral structure of the device, the action of the reservoir type powder inhalation device for dividing the dose is changed into the push-twist from the original rotary knob, and a user can complete the whole using operation steps of the inhaled medicine by one hand.

Description

Push-and-turn storage type aerosol powder device

Technical Field

The invention belongs to the field of instruments for inputting media into human bodies, and particularly relates to an inhalation type drug delivery device.

Background

The powder inhalation is widely applied to the treatment of asthma, chronic obstructive pulmonary disease and other diseases, is presented to patients as a medicinal and mechanical combination product, and plays an important role in the powder inhalation device, so that the powder inhalation device needs to effectively deliver medicines on one hand, and the use compliance of the patients needs to be solved on the other hand.

Compared with other similar inhalation preparation products, the powder inhalation has the following advantages:

1) small in size, portable (compared to atomizers);

2) no synergistic problem (compared to aerosol) when used by patients;

3) the cost, difficulty of manufacture are relatively low and the applicability is wide (compare soft mist agent Softmist).

Due to the advantages, the powder cloud agent is a hot spot for research of many scholars at home and abroad.

According to the medicine storage mode, the powder inhalation product can be divided into: capsule type dry powder aerosols (Capsule), depot dry powder aerosols (Reservoir), and vesicle dry powder aerosols (Blister).

The capsule type atomized powder device is characterized in that the medicinal powder is filled into a capsule in advance, the capsule is broken through a puncture needle (generally, the puncture needle is a puncture needle, and a few devices are used for twisting or breaking the capsule), and then medicinal particles are delivered out through the inspiratory airflow of a patient; for the vesicle type atomized powder device, generally, the medicine powder is subpackaged in small vesicles (made of aluminum foil) according to the set dosage, when in use, the aluminum foil is torn open by the device, and the medicine powder falls into a flow channel and is taken away by the air flow of the patient; in the case of a reservoir type aerosol device, the medicament powder is filled in a medicament storage barrel in advance, and when the device is used by a patient, a single-inhalation dose (dose) is separated by the aerosol device, and the single-inhalation dose is taken away by the inhalation airflow.

The simplification of the device operation steps is one of the important factors to be considered for the design of the powder aerosol device.

The ease of operation of the device can affect the therapeutic efficacy of the product itself, in addition to the user experience of the patient. Complex operational designs increase the probability of device misuse, and incorrect device operation may result in devices that fail to deliver and dispense drugs properly or effectively, thereby resulting in a significant loss of clinical efficacy. Therefore, simplification of the operation steps is very important in designing the powder atomizing device.

However, most of the conventional powder aerosol devices are not convenient to operate. For example, in the case of a capsule type aerosol powder product, a patient manually fills a capsule into the device when using the capsule, then punctures the capsule by pressing a button with a hand, and pours out an empty capsule from the device after using the capsule, which is complicated in steps.

Compared with the prior art, the traditional reservoir type powder aerosol device and the vesicle type powder aerosol device avoid the complicated step of repeatedly filling capsules, and can be repeatedly used by patients within a certain inhalation frequency range.

However, the conventional reservoir type powder inhalation device still has many problems (the focus of the discussion in this patent is reservoir type powder inhalation product), such as a person believes a certain insurance (the manufacturer is astrazen), and a patient needs to rotate a red knob at the bottom of the device before inhaling the medicine, but according to the related literature reports at home and abroad, the situation that the knob cannot be rotated to the right position or the knob is forgotten to be rotated to the initial position after being rotated to the right position easily occurs in the using process of the patient. In addition, during operation, the patient needs to participate in the operation with both hands (holding the device with one hand and operating with the other hand) to normally use the powder inhalation device.

At present, in response to this situation, foreign countries have come up with solutions that integrate the operating steps of the device into the opening of the lid, i.e. a "one-step" operation (opening the lid → sucking the drug → closing the lid). The scheme simplifies the operation steps of the dry powder inhalation device, and removes the extra steps required before the patient formally inhales the medicine, thereby greatly reducing the errors possibly occurring in the operation process, avoiding the error condition occurring in the rotation of the knob as a certain guarantee, such as the rotation is not in place, the knob is not rotated, and the knob is not rotated to the initial position after being rotated to the right side.

While the "one-step" operation greatly reduces the number of steps required to operate the device, it typically requires one hand to hold and the other hand to remove the cover while the patient is operating. If a patient suffers from a sudden attack (asthma), the convenience and the rapidity of the two-hand operation are not the same as those of the one-hand operation in an emergency state (the possible emergency condition is the attack of the patient during driving or the attack of the patient during working at a desk), and the two-hand operation is convenient and quick (from the aspects of rapidness and convenience).

Currently, in the market, there are relatively few DPI devices (drypwerinhalers) capable of being operated by one hand before inhalation, and G air is a few devices capable of being operated by one hand directly before inhalation, but the whole shape of the G air is flat, so that a patient holds the device with his thumb and presses his middle finger at the position of the button, in an emergency, if the patient operates the device quickly, the device may tilt (there is a moment due to the distance between the two fingers), and the reservoir type aerosol device generally uses the gravity of the powder particles to dispense the drug, and the tilting of the device will inevitably tilt the drug storage barrel, thereby causing inaccurate particle dispensing.

At present, the three prior-developed products sold in the domestic market are as follows: sitexan (H x ler), Shutexan (D x kus), and Turxan (Tur x ler), all of which require additional steps and two-handed operation before the patient can take the drug.

Disclosure of Invention

The invention aims to solve the technical problem of providing a push-and-twist storage type aerosol powder device. The push button is added, so that the intuition of operation (namely, the push button is pushed to operate at first sight) can be provided for a patient (user) from intuition and sense of touch, and the misuse rate of the device is reduced to a certain extent; aiming at the push-button pushing operation design, a series of matched mechanical structures are carried out; based on push-and-twist operation, the structural modules of the device are spatially arranged; the operation steps of the powder inhalation device are simplified, and the operation steps of the divided dose (operation steps before medicine inhalation) can be simplified from double-hand operation (one hand holds the device and the other hand rotates a knob) into single-hand operation-push-and-twist action.

The technical scheme of the invention is as follows: the utility model provides a push away formula storehouse type powder cloud agent device of turning round, characterized by:

the integral structure of the device comprises a suction nozzle, an upper shell, an upper middle shell, a lower middle shell and a bottom shell which are arranged in sequence;

the upper shell is provided with a device air inlet;

a push button is arranged on the middle upper shell;

wherein, a medicine storage barrel, a medicine pit plate, a spring, a lower rail, an upper rail, a cover plate, a device flow passage and a connecting rod are arranged in the upper shell and the upper shell;

a first ratchet wheel and a second ratchet wheel are arranged in the middle lower shell;

a gear cover plate, a transition gear and a counting gear are arranged in the bottom shell;

the upper shell, the middle lower shell and the bottom shell are coaxially arranged;

the medicine pit disc, the spring, the lower rail, the upper rail, the cover plate, the gear cover plate, the first ratchet wheel, the second ratchet wheel, the counting gear and the connecting rod are coaxially arranged;

the push-and-twist type storage type aerosol powder device is characterized in that the push-and-twist structural design is added in the overall structure of the device, the action of dividing the dose of the storage type aerosol powder device is changed from the original rotary knob to the push-and-twist action, and the whole using operation steps of inhaling the medicament can be completed by one hand from the operation angle of a user.

Specifically, the push-and-turn type storage aerosol powder device has the advantages that in the rotating process of the first ratchet wheel and the second ratchet wheel, the pawl of the second ratchet wheel and the pawl of the first ratchet wheel are compressed and deformed, then released and generate a sound, and the push-and-turn button is pushed in place in a prompt mode, so that the situation that a patient cannot push the push-and-turn button to be in place is prevented.

Specifically, the first ratchet wheel and the second ratchet wheel form a damping structure after being combined, certain resistance is given to the push button in the process of pushing the push button, operation safety is guaranteed, and misoperation of a patient is prevented.

Specifically, the push-and-twist type storage aerosol powder device simplifies the operation steps of dose division before drug inhalation from two-hand operation to one-hand operation-push-and-twist type action; and simultaneously ensures the functions of counting, storing the medicine and delivering and dispersing the medicine required by the storage type dry powder inhalation device.

Specifically, the lower rail and the upper rail are sleeved on the connecting rod and are coaxially matched with each other; the upper end of the connecting rod is connected with the medicine pit disc, and the lower end of the connecting rod is connected with the second ratchet wheel through the coupler; a main gear is arranged at one end of the first ratchet wheel, a pawl is arranged on the periphery of the other end of the first ratchet wheel, and a pawl groove is arranged on the inner ring of the other end of the first ratchet wheel; one end of the second ratchet wheel is provided with a cross shaft, and the other end of the second ratchet wheel is provided with a pawl; a runner air inlet is arranged on the runner of the device; at least one medicine pit is arranged on the medicine pit plate; the medicine storage barrel and the device flow channel are positioned and spliced into a whole by arranging at least one group of pin holes and corresponding pin shafts.

Furthermore, the push-twist type storage type aerosol powder device realizes the function of 'dose distribution' by arranging a push-twist linkage structure; the connecting rod penetrates through the cross hole of the lower rail and the cross hole of the upper rail, so that the shaft holes are matched, and the rotating directions of the lower rail, the upper rail and the connecting rod are consistent; the upper limit and the lower limit of the lower track and the upper track are realized through the upper shell, the cover plate and the lower shell, and after the limit is formed, a rising channel along a cylindrical surface curve is formed between the track surfaces of the lower track and the upper track; the ascending channel and the rolling hemisphere realize a point contact mode of attachment, when the push button moves upwards along the push button slide rail, the rolling hemisphere and the push button clamping groove component move upwards along with the push button, the upper rail rotates under the action of the upward acting force of the rolling hemisphere, and the lower rail and the connecting rod rotate together due to the fact that the rotating directions of the lower rail, the upper rail and the connecting rod are consistent; the connecting rod rotates to drive the medicine pit disc to rotate, the medicine pits on the medicine pit disc are rotated to the position of the medicine powder outlet from the lower part of the medicine storage barrel, single-dose-sucking medicines separated from the medicine storage barrel are carried in the medicine pits in the rotating process, and the function of dividing the dose is finally realized; along with the air flow entering from the flow passage air inlet of the device flow passage, the medicine powder in the medicine pit can be entrained away and enters the flow passage space formed by the upper flow passage cavity and the lower flow passage cavity, and the medicine particles are dispersed under the action of the air flow turbulence, so that the medicine particles are inhaled into the lung of a patient.

Furthermore, the inner part of the medicine storage barrel is of a straight-through structure; the upper end face of the medicine pit plate is in fit contact with the bottom face of the medicine storage barrel, and the medicine storage barrel is sealed by the medicine barrel cover to form a closed space of the medicine storage barrel, so that the function of storing medicine powder is realized.

Furthermore, in the process of moving the push button upwards, the first ratchet wheel does not rotate, only the second ratchet wheel rotates, the counting gear and the transition gear do not rotate at the moment, the number printed on the outer side of the counting gear does not change, and meanwhile, when the second ratchet wheel rotates to the position of 90 degrees, the pawl of the second ratchet wheel can be clamped into the pawl groove of the first ratchet wheel, and the pawl is compressed from deformation to release to make a crisp 'sound'; when the push button moves downwards, under the influence of the rotation of the connecting rod and the coupling, the second ratchet wheel rotates towards the other direction, the rotation direction of the second ratchet wheel is opposite to the direction of the pawl of the second ratchet wheel, the pawl of the second ratchet wheel pushes against the first ratchet wheel to rotate, and because the rotation direction is consistent with the direction of the pawl of the first ratchet wheel, the first pawl rotates in the process of moving downwards of the push button, the transition gear and the counting gear are driven to rotate, and the change of the number of the counter is realized; meanwhile, the first ratchet wheel rotates 90 degrees and then is clamped into the ratchet wheel clamping groove of the first ratchet wheel, and in the clamping process, the pawl of the first ratchet wheel is compressed and deformed and then released, so that a crisp 'sound' can be generated again; by adopting the structure and the component movement mode, the push-twist storage type aerosol powder device realizes the function of voice prompt in the process of pushing, twisting and dividing the dose.

The technical scheme of the invention also provides a push-and-twist type storage type aerosol powder device, which is characterized by comprising the following operation steps:

1) a vertical holding device;

2) pushing the push button;

3) and (5) sucking the medicine.

Further, the reservoir type aerosol powder device adopts a push-and-twist operation mode, namely a one-hand operation mode:

firstly, vertically holding the device by a single hand;

the second part is pushed and twisted by the thumb of the holding hand of the patient to carry out the dosage division;

thirdly, sucking the medicine by mouth;

in the above-described operation steps, the patient does not need to use the other hand to perform auxiliary holding on the device.

Compared with the prior art, the invention has the advantages that:

1. the design scheme of this patent has added and has pushed the design of turning round, with the action of storehouse type dry powder inhalation device partial dose, changes the promotion by original rotation knob and pushes away the turn round, from the angle of user (patient) operation, such operating mode can be realized by the one hand (has liberated another hand), and concrete operating procedure has just become: 1) a vertical holding device; 2) pushing the push button; 3) medicine suction; the operation steps are convenient for patients suffering from asthma emergency;

2. the push-button action design of the device in the technical scheme of the invention can give an intuition to a user (operator) to a certain degree for using feeling, namely, the device needs to be triggered by the push button, and the error rate (a certain guarantee of contrast information) of the device can be reduced to a certain degree;

3. the voice prompt function in the device can tell whether the patient operates correctly, and a damping system formed by overlapping the first ratchet wheel 13 and the second ratchet wheel 14 can give certain operation safety to the push button (namely, the push button is not too loose, so that the patient has misoperation);

4. by adopting the technical scheme of the invention, the operation steps of the divided dose (the operation steps before medicine suction) can be simplified from two-hand operation (one hand holds the device and the other hand rotates the knob) into one-hand operation, namely push-and-twist action; simultaneously, the essential characteristics and characteristics required by the storage type atomized powder device are ensured: counting, storing, and delivering dispersed medication.

Drawings

FIG. 1a is a schematic overall cross-sectional view of the apparatus of the present invention;

FIG. 1b is a schematic view of the overall appearance of the device of the present invention;

FIG. 2 is a schematic view of a push-and-twist linkage rotary structure of the present invention;

FIG. 3 is a schematic view of the structural cooperation between the flow channel and the drug storage barrel of the present invention;

FIG. 4 is a schematic structural view of the lower rail;

FIG. 5 is a schematic structural view of an upper track;

FIG. 6 is a schematic view of the manner in which the lower and upper rails are assembled;

FIG. 7 is a schematic view showing the assembly effect of the upper and lower rails;

FIG. 8 is a schematic view of the internal structure of the upper shell;

FIG. 9 is a right side view of the upper housing appearance;

FIG. 10 is a schematic cross-sectional view of the upper shell;

FIG. 11 is a schematic view of the outer appearance and inner structure of the medicine storage barrel;

FIG. 12 is a schematic view of the assembled relationship between the drug storage barrel and the upper housing;

FIG. 13 is a cross-sectional view of the assembled relationship between the drug storage barrel and the upper housing;

FIG. 14a is a schematic view of a counter gear drive configuration;

FIG. 14b is a cross-sectional structural view of the counter gear drive;

FIG. 15 is a schematic view of the first ratchet;

FIG. 16 is a structural view of a second ratchet;

FIG. 17 is a schematic view of an assembled structure of the first ratchet and the second ratchet;

FIG. 18 is a schematic structural view of a counting structure;

FIG. 19 is a schematic cross-sectional view of a counting structure;

FIG. 20 is a schematic view of the configuration of the flow channel of the device;

FIG. 21 is a schematic side view of the device flow channel;

FIG. 22 is a schematic bottom view of the device flow channel;

FIG. 23 is a schematic structural view of a push-and-twist construction;

FIG. 24 is a schematic view showing the fixing manner of the upper and lower rails;

FIG. 25 is a schematic view of the structure of the middle lower case;

fig. 26 is a schematic view of the external configuration in the front view direction of the middle-lower case;

fig. 27 is a sectional structural view of the middle-lower case;

FIG. 28 is a schematic view of the fit between the well plate and the tie bar;

FIG. 29 is a schematic view of the assembled structure of the pill well plate, the connecting rod, the coupling and the ratchet;

FIG. 30 is a schematic top view of the coupling;

fig. 31 is a schematic view of the bottom profile of the coupling.

In the figure, 1 is a suction nozzle; 2 is an upper shell; 3, a medicine storage barrel, 301, 302 and 303, a pin shaft, 304, a positioning groove, 305, a lower runner cavity, 306, a medicine powder outlet and 307, a buckling hole; 4, a medicine pit plate, 401 is a cross hole; 5 is a spring; 6 is a lower rail, 601 is a lower rail cross hole, 602 is a lower rail guide surface, and 67 is a lifting channel; 7 is an upper rail, 701 is an upper rail cross hole, and 702 is an upper rail guide surface; 8 is a cover plate; 9 is a gear cover plate; 10 is a transition gear; 11 is a bottom shell; 12 is a middle-lower shell, 120 is a hole, 121 is a ratchet clamping groove, 122 is a clamping groove, and 123 is a buckle; 13 is a first ratchet wheel, 130 is a main gear, 131 is a pawl, and 132 is a pawl slot; 14 is a second ratchet wheel, 140 is a cross shaft; 141 is a pawl; 15 is a device flow channel; 16 is a push button, 161 is a push button slot part, and 162 is a rolling hemisphere; 17 is a counting gear; 18 is a coupler, 181 is an upper cross hole, and 182 is a lower cross hole; 19 is a connecting rod; 21 is a medicine barrel cover; 201 is a flow channel air inlet, 202, 203 and 204 are pin holes, 205 is a flow channel stepped surface, 206 is a tangential air inlet, and 207 is an upper flow channel cavity; 22 is an upper shell, 221 is a buckling hole, 222 is a positioning protrusion mechanism, 223 is a support rib, 224 is a step surface, 225 is a buckle, 226 is a push-button sliding rail, and 227 is a clamping groove; 23 is the device air inlet; 34 is a closed space of the medicine storage barrel, and 40 is a medicine pit.

Detailed Description

The invention is further described below with reference to the accompanying drawings.

As shown in fig. 1a, 1b and 2, the overall structure of the device of the present invention comprises a suction nozzle 1, an upper housing 2, an upper middle shell 22, a lower middle shell 12 and a bottom shell 11 which are arranged in sequence, wherein the upper housing 2 is provided with a device air inlet 23, and the upper middle shell 22 is provided with a push button 16.

Wherein, the upper shell 2 and the upper middle shell 22 are provided with a medicine storage barrel 3, a medicine pit plate 4, a spring 5, a lower track 6, an upper track 7, a cover plate 8, a device flow passage 15 and a connecting rod 19;

a first ratchet wheel 13 and a second ratchet wheel 14 are arranged in the middle-lower shell 12;

a gear cover plate 9, a transition gear 10 and a counting gear 17 are arranged in the bottom shell 11;

the upper shell 2, the upper middle shell 22, the lower middle shell 12 and the bottom shell 11 are coaxially arranged;

the medicine pit plate 4, the spring 5, the lower track 6, the upper track 7, the cover plate 8, the gear cover plate 9, the first ratchet wheel 13, the second ratchet wheel 14, the counting gear 17 and the connecting rod 19 are coaxially arranged.

The lower track 6 and the upper track 7 are sleeved on the connecting rod 19; the three are coaxially matched; the upper end of the connecting rod is connected with the medicine pit disk 4, and the lower end of the connecting rod is connected with the second ratchet wheel 14 through the coupler 18.

A runner inlet 201 is provided in the device runner 15.

The positioning and the splicing are integrated by arranging at least one group of pin holes and corresponding pin shafts between the medicine storage barrel and the device flow channel.

At least one medicine pit 40 is provided on the medicine pit tray 4.

The upper end of the medicine storage barrel 3 is provided with a medicine barrel cover 21.

A main gear 130 is provided at one end of the first ratchet 13, a pawl 131 is provided on the outer periphery of the other end of the first ratchet 13, and a pawl groove 132 is provided on the inner periphery of the other end of the first ratchet 13.

A cross 140 is provided at one end of the second ratchet 14, and a pawl 141 is provided at the other end of the second ratchet 14.

The first ratchet wheel and the second ratchet wheel form a damping structure after being combined, and certain resistance is given to the push button 16 in the process of pushing the push button 16; meanwhile, in the process of rotating the first ratchet wheel 13 and the second ratchet wheel 14, the pawl of the second ratchet wheel and the pawl of the first ratchet wheel are compressed and deformed, then released and generate a sound to prompt that the push button is pushed in place, so that the situation that a patient cannot push the push button to the place is prevented.

The core structure of the device for realizing the function of 'dividing the dose' is a push-turn motion linkage structure which is mainly based on the principle of a cylindrical cam in mechanical design.

The specific mode is as follows: the lower rail 6 and the upper rail 7 are designed in a structure as shown in fig. 4 and 5, and a cross hole is correspondingly formed at the center of each of the rails and the upper rail.

As shown in fig. 6 and 7, the lower rail 6 and the upper rail 7 are coaxially matched through the connecting rod 19 by inserting the connecting rod 19 through the cross hole 601 of the lower rail 6 and the cross hole 701 of the upper rail 7 to realize the shaft hole matching (as shown in fig. 7).

Based on the structure of the cross shape, the rotation directions of the lower track 6 and the upper track 7 can be ensured to be consistent with the rotation direction of the connecting rod 19, which is the premise of realizing the mechanical action of the pushing and twisting mechanism.

Next, the upper and lower limits of the lower rail 6 and the upper rail 7 are realized by the upper and lower shells 22, 8 and 12, as shown in fig. 24 (a certain gap exists between the cover plate 8 and the lower rail 6 and the upper rail 7, which is about 0.2mm, and facilitates the coaxial rotation of the lower rail 6 and the upper rail 7), after the limit is formed, a rising channel 67 along the curve of the cylindrical surface is formed between the rail surfaces of the lower rail 6 and the upper rail 7.

The ascending channel 67 can be attached to the roller hemisphere 162 (point contact), when the push button 16 moves upward along the push button rail 226 (the push button rail structure is shown in fig. 9), the roller hemisphere 162 and the push button slot 161 move upward together with the push button 16 (the roller hemisphere 162 can rotate around the pin of the push button slot 161, the assembly structure of the two is shown in fig. 23), and when the upper rail 7 rotates (counterclockwise when viewed from top to bottom) under the upward force of the roller hemisphere 162, the lower rail 6 and the connecting rod 19 rotate together because the rotation directions of the lower rail 6, the upper rail 7 and the connecting rod 19 are the same.

The connecting rod 19 rotates to drive the medicine pit disk 4 to rotate, the medicine pit 40 on the medicine pit disk 4 rotates to the position of the medicine powder outlet 306 from the lower part of the medicine storage barrel 3, and single-inhalation dose medicines which are separated from the medicine storage barrel 3 are carried in the medicine pit 40 in the rotating process.

With the airflow entering from the flow channel inlet 201 of the device flow channel 15, the medicine powder in the medicine pit 40 is entrained and enters the flow channel space formed by the upper flow channel cavity 207 and the lower flow channel cavity 305, and under the action of the airflow turbulence (mainly inside the flow channel), the medicine particles are dispersed, so that the medicine particles are inhaled into the lung by the patient.

In the above structural design, the rail structure is divided into the lower rail 6 and the upper rail 7, mainly considering the difficulty and cost of injection molding. The lower rail 6 and the upper rail 7 may be integrally formed in order to reduce the number of parts. In addition, the connecting rod 19 can be integrated with the lower rail 6 and the upper rail 7 (injection molding) for cost reasons, and this patent shows only an example, but is not limited to this in actual device development.

The appearance and structure of the medicine storage barrel 3 are shown in fig. 1a, fig. 3, fig. 11, fig. 12 and fig. 13, and the basic function is medicine storage function, and the main characteristic of the storage type powder inhalation is different from other types of powder inhalation products. Medicine powder can not be directly stored in the medicine storage barrel 3, because the medicine storage barrel 3 is straight-through, a closed space can be formed by the medicine storage barrel 3 and the upper shell 22 (fixedly positioned medicine storage barrel 3) and the medicine pit plate 4 (attached to the bottom surface of the medicine storage barrel 3), and thus the function of storing medicine powder is achieved.

The specific implementation mode is as follows: the edge of the drug storage barrel 3 has a structure of a snap hole 307 (shown in fig. 11), and the inner ring of the upper shell 22 has a structure of a snap 225 (shown in fig. 8). During installation, the medicine pit plate 4 is firstly aligned with a circle formed by the inner side of the stepped surface 224 and is placed in the circle, and the medicine pit plate 4 is placed stably under the action of the support ribs 223. Then, the medicine cartridge 3 is put into the inner space, and the catch 225 of the inner ring of the upper shell 22 is caught by the catch hole 307, thereby fixing the components of the medicine cartridge 3. Thus, a space for storing the medicine, namely, a medicine storage barrel closed space 34 (shown in fig. 14 b) is formed among the medicine storage barrel 3, the medicine pit tray 4 and the upper shell 22.

In the case of a powder aerosol device (regardless of the type of powder aerosol device), the flow channel is the most critical device component, and the dispersion efficiency of one device is high or low, besides the prescription design, the flow channel design of the device needs to be seen, and the influence of the geometric structure of the flow channel on the dispersion result of the powder aerosol is great.

In the present embodiment, the device flow channel 15 has an outer shape as shown in fig. 3, 20, 21 and 22, and the device flow channel 15 has pin holes 202, 203 and 204 for matching with the pin 301, 302 and 303 to form a shaft hole, thereby fixing the device flow channel 15. The upper runner cavity 207 of the device runner 15 and the lower runner cavity 305 of the medicine storage barrel 3 are assembled to form a complete dispersion channel cavity. The geometric shape of the cavity is shown in fig. 22, and it can be seen from the figure that the overall shape of the interior of the upper flow channel cavity 207 in the device flow channel 15 is a vortex shape, which enables the bending rate of the air flow in the flow channel to be larger, so that the collision between the particles and the interior of the device flow channel cavity is more severe, and the drug particles are better dispersed.

With respect to the specific working principle of the air flow entering from the air inlet of the flow passage of the device and carrying away the powder in the medicine pit, reference may be made to the related descriptions of the air inlet, the medicine pit, the medicine inlet passage and the vortex cavity in the Chinese patent application with application date of 2021, 8, month and 3 and application number of 202110886052.3, which was previously applied by the applicant, and also reference may be made to the related descriptions of the preparation atomization flow passage in the Chinese patent application with authorization publication date of 2021, month and 29 and authorization publication number of CN 107715264B, which was previously applied by the inventor related to the pharmaceutical company shanghai new yellow river, which is related to the preparation atomization flow passage in the dispersion/deagglomeration device of powder agglomerates of the powder aerosol device, which is previously applied by the applicant, and the detailed description thereof will not be repeated herein.

As a reservoir type dry aerosol device, there is also a necessary function, namely a counting function, which is intended to tell the patient how many doses are available.

As can be seen from fig. 14a and 14b, as the push button 16, the rolling semi-sphere 162 and the push button slot 161 move upward, the lower rail 6 and the upper rail 7 are rotated, the rotation of the two components simultaneously drives the connecting rod 19, the rotation of the connecting rod 19 simultaneously drives the rotation of the coupling 18, and the rotation of the coupling 18 drives the second ratchet wheel 14 to rotate along the direction of the pawl 141, while for the first ratchet wheel 13, the rotation direction of the pawl 141 of the second ratchet wheel is opposite to the direction of the pawl, so that only the second ratchet wheel 14 rotates and the first ratchet wheel 13 does not rotate during the upward movement of the push button 16.

As shown in fig. 15 to 19, the main gear 130 is disposed on the other side of the first ratchet 13, and the main gear 130 is engaged with the transition gear 10 and the counter gear 17 through gears to achieve transmission matching among different numbers of teeth. The transmission ratio is 18: 1 (gear ratio between the main gear 130 and the counter gear 17), i.e. the main gear 130 rotates 90 degrees and the counter gear 17 rotates 5 degrees.

Since only the second ratchet wheel 14 rotates and the first ratchet wheel 13 does not rotate during the process of moving the push button 16 upwards, neither the counter gear 17 nor the transition gear 10 rotates at this time, the number printed on the outer side of the counter gear 17 does not change (i.e. the remaining dose does not change), and when the second ratchet wheel 14 rotates to the 90-degree position, the pawl 141 is clamped in the pawl groove 132, and a crisp "sound" is generated due to the compression and release of the pawl from deformation.

When the push button 16 moves downwards, similarly influenced by the rotation of the connecting rod 19 and the coupling 18, the second ratchet wheel 14 rotates in the other direction, but the rotation direction is opposite to the direction of the pawl 141, and the pawl 141 of the second ratchet wheel 14 rotates against the first ratchet wheel 13 (the second ratchet wheel 14 does not rotate), and because the rotation direction is consistent with the direction of the pawl 131 of the first ratchet wheel 13, the first pawl 13 rotates during the downward movement of the push button 16, so that the transition gear 10 and the counting gear 17 rotate, the number of the counter is changed, and similarly, because the first ratchet wheel 13 rotates 90 degrees, the counter is clamped into the ratchet clamping groove 121 (as shown in fig. 25), and during the clamping, because the pawl 131 is compressed and deformed, the release can generate a crisp sound again.

In summary, the push button 16 realizes the in-place sound prompt in the process of moving up and down, which is mainly generated by the deformation of the pawl 141 and the pawl 131 in the rotation process of the first ratchet 13 and the second ratchet 14. And the two times of sounds have certain difference: the difference is that the second rattle is greater because the second rattle is caused by the deformation of the pawl 131, and the pawl 131 is geometrically larger than the pawl 141.

This technical scheme carries out a series of supporting mechanical structure designs to the promotion operation design of "pushing away the knob", includes:

1) how to realize the push-button linkage dose division function;

2) how to realize the voice prompt function in the process of pushing, twisting and dividing the dose;

3) based on the push-and-twist action design, how to design a flow channel;

4) how to implement and design the counting function (calculate what the remaining dose is) based on the push-and-twist action;

5) based on the push-and-twist action, how to design the shapes of the rest parts and the matching among the parts.

Through the design scheme, the reservoir type dry aerosol device disclosed by the patent firstly realizes the functions required by the basic reservoir type dry aerosol device: drug storage, drug dispensing, counting (dose counting) and sub-dosing (single inhalation dose isolated from the drug storage barrel for patient use). On the basis, the possibility of operating the device by one hand of the patient and the function of voice prompt (prompting the patient whether the operation is correct or not) are realized.

It should be noted that the fixing means between the medicine storage barrel 3 and the upper shell 22 is the snap 225 (the snap is evenly distributed along the circumference, the snap 225 is snapped into the snap hole 307), and the main function of the spring 5 below the medicine pit plate 4 is to make the medicine pit plate 4 and the bottom surface of the medicine storage barrel 3 fit together as much as possible by the elastic force of the spring.

In consideration of actual processing conditions (whether demolding can be performed or not, most of powder aerosol device parts related to the technical scheme are manufactured in an injection molding mode), the difficulty of manufacturing the lower rail 6 and the upper rail 7 into one part is large, and therefore the slide rail parts are designed into an upper part and a lower part, namely the lower rail 6 and the upper rail 7. In practical applications, the slide rail is not limited to the design of the slide rail disclosed in this patent, and for example, the slide rail is formed by rotating and demolding the lower rail 6 and the upper rail 7 after they are integrated.

Further, a damping structure composed of a first ratchet wheel 13 and a second ratchet wheel 14 is arranged below the slide rail structure and above the counting disc, and the extending directions of the pawls 131 and 141 of the two ratchet wheels are opposite. Because the pawl 141 and the pawl 131 are deformed and compressed during the rotation process, the patient can not loosen too much in the process of pushing the push button 16 (including downward moving the push button 16), namely, the damping structure consisting of the first ratchet wheel 13 and the second ratchet wheel 14 gives a certain resistance to the push button 16, so that the user can not feel too loose when sliding. Meanwhile, the sound prompt for pushing the push button is given to the patient, and the sound is generated because the pawl 141 and the pawl 131 are compressed and deformed and then released in the process of rotating the first ratchet wheel 13 and the second ratchet wheel 14 (the sound prompt indicates that the push button is pushed in place, so that the situation that the push button cannot be pushed down by the patient is prevented). The pawls (between the finger pawl 131 and the pawl 141) of the first ratchet wheel 13 and the second ratchet wheel 14 are distributed at intervals of 90 degrees.

It should be noted that the upper housing 22 of the device is engaged with the drug storage barrel 3 (as shown in fig. 13) by means of a snap 225, which is designed to facilitate filling of the drug storage barrel 3 (the last filling step may be filling the drug and then covering)

Specifically, the structure of the medicine storage barrel 3 is designed to be communicated with each other at two ends, so that the demolding is facilitated.

The medicine pit plate 4 contacts and is attached to the bottom surface of the medicine storage barrel 3, and a medicine storage barrel closed space 34 is formed by sealing the medicine barrel cover 21.

It should be noted that, when the lower rail 6 and the upper rail 7 are installed, the lower rail 6 and the upper rail 7 are first attached, and then the connecting rod 19 is inserted into the lower rail cross hole 601 of the lower rail 6 and the upper rail cross hole 701 of the upper rail 7 in alignment, so as to achieve positioning and installation (as shown in fig. 6 and 7).

As shown in fig. 8, 9 and 10, the supporting ribs 223 inside the upper middle shell 22 are configured to support the medicine pit tray 4, and the locking slots 227 (shown in fig. 26) at the bottom of the upper middle shell 22 are configured to be matched with the locking tabs 123 (shown in fig. 27) of the lower middle shell 12.

The cross hole 401 on one side of the medicine pit plate 4 is matched with the connecting rod 19 (as shown in fig. 28), and the medicine pit plate 4 can synchronously rotate with the connecting rod 19 based on the design of a cross shape.

The top of the second ratchet 14 has features of a cross 140 that cooperates with a lower cross 182 of the coupler 18 (as shown in fig. 29 and 31) to effect rotation of the second ratchet 14 and the coupler 18 in the same direction. The upper cross hole 181 (shown in fig. 30) above the coupler 18 is matched with the connecting rod 19 to realize the synchronous rotation of the connecting rod 19 and the coupler 18, and in summary, the mechanical structure design can realize the synchronous rotation of the coupler 18, the connecting rod 19 and the second ratchet 14. According to the above, since the chemical pit plate 4 and the connecting rod 19 can be rotated synchronously, the chemical pit plate 4, the connecting rod 19, the coupling 18, and the second ratchet 14 can be rotated synchronously.

In the present solution, the cavity inside the device channel 15 (as shown in fig. 22) is in a spiral shape, and has a tangential air inlet 206, which is used for tangential air inlet, and forms a highly turbulent airflow field in the upper channel cavity 207 of the device channel 15.

Based on the structural design and the mutual matching, the specific operation steps of the device are changed as follows:

1) a vertical holding device;

2) pushing the push button;

3) and (5) sucking the medicine.

The operation steps are convenient for patients suffering from asthma emergency.

The technical key points of the technical scheme of the invention are as follows by combining the description:

1) the device has the following design concept scheme of push-turn linkage: after the patient pushes the push button, the powder aerosol device completes the distribution of single inhalation dose; the patient withdraws the push button, and the medicine pits with divided doses are transferred back to the storage;

2) this device adopts the mode of operation of pushing away the formula of turning round: namely, the mode of one-handed operation: the first step is to hold the device vertically with one hand, the second step is to push and twist the thumb of the patient holding hand to perform the dose division, and the third step is to suck the drug with mouth. In the above-described operation steps, the patient does not need to use the other hand to perform auxiliary holding on the device.

3) The design of the guide rail structure related to the push-turn linkage structure comprises the following steps: the principle of a mechanical cylindrical cam is adopted to realize linkage between pushing and twisting pushing and rotation of the medicine pit plate. It should be noted that, in this patent, the guide rail is designed as two parts, i.e. the lower rail 6 and the upper rail 7, for the requirement of convenient processing, and other ways may also be adopted in practical processing for reducing the number of parts, for example, the lower rail 6 and the upper rail 7 are directly combined as 1 part, and a rotary demolding way is adopted during demolding, which is not limited to the way described in the embodiment of this patent.

4) The superimposed damping structure composed of the ratchet wheel 13 and the ratchet wheel 14 and adopted in the device plays a damping effect through the deformation compression of the pawl 131 and the pawl 141 in the rotating process of the two ratchet wheels, and the formed mechanical resistance is used for preventing the pushing and twisting from becoming too loose, so that the misoperation of a patient is prevented to a certain extent. Meanwhile, the sound prompt function of the whole structure in the process of moving the push button up and down is achieved through the sound generated by the deformation to the release in the whole process that the pawl 131 of the ratchet wheel 13 and the pawl 141 of the ratchet wheel 14 are clamped into the ratchet wheel groove after rotating for 90 degrees.

5) The medicine pit plate 4, the lower track 6 and the upper track 7 are coaxially matched through the connecting rod 19, linkage rotation is achieved based on the cross design of the connecting rod 19, and the rotation directions of the medicine pit plate 4, the lower track 6 and the upper track 7 are consistent.

In summary, according to the technical scheme of the present invention, the push button structure and the corresponding matching structure are arranged, so that the action of dispensing the reservoir type aerosol device is changed from the original rotation knob to the push button, and the operation mode of the user (patient) can be realized by one hand; the push-twist action design of the device can give users (operators) an intuition of using feeling, and the error rate of the device is reduced; the voice prompt function sent out inside the device can tell whether the patient operates correctly or not, and can give certain operation safety to the push button.

The invention can be widely applied to the design and manufacture field of the storage type powder aerosol device.

Claims (10)

1. The utility model provides a push away formula storehouse type powder cloud agent device of turning round, characterized by:

the integral structure of the device comprises a suction nozzle, an upper shell, an upper middle shell, a lower middle shell and a bottom shell which are arranged in sequence;

the upper shell is provided with a device air inlet;

a push button is arranged on the middle upper shell;

wherein, a medicine storage barrel, a medicine pit plate, a spring, a lower rail, an upper rail, a cover plate, a device flow passage and a connecting rod are arranged in the upper shell and the upper shell;

a first ratchet wheel and a second ratchet wheel are arranged in the middle lower shell;

a gear cover plate, a transition gear and a counting gear are arranged in the bottom shell;

the upper shell, the middle lower shell and the bottom shell are coaxially arranged;

the medicine pit plate, the spring, the lower rail, the upper rail, the cover plate, the gear cover plate, the first ratchet wheel, the second ratchet wheel, the counting gear and the connecting rod are coaxially arranged;

the push-and-twist type storage type aerosol powder device is characterized in that the push-and-twist structural design is added in the overall structure of the device, the action of dividing the dose of the storage type aerosol powder device is changed from the original rotary knob to the push-and-twist action, and the whole using operation steps of inhaling the medicament can be completed by one hand from the operation angle of a user.

2. The push-and-turn type aerosol reservoir device according to claim 1, wherein the pawl of the second ratchet and the pawl of the first ratchet are compressed and deformed during the rotation of the first ratchet and the second ratchet, and then released to generate a sound to indicate that the push-and-turn button is pushed in place, thereby preventing the occurrence of the situation that the patient cannot push the push-and-turn button.

3. The push-button aerosol storage device as claimed in claim 1, wherein the first ratchet and the second ratchet are combined to form a damping structure, so as to provide a certain resistance to the push button during pushing the push button, thereby ensuring the safety of operation and preventing the misoperation of patients.

4. The push-and-twist aerosol reservoir system of claim 1, wherein the push-and-twist aerosol reservoir system simplifies the dispensing steps from two-handed operation to one-handed operation; and simultaneously ensures the functions of counting, storing the medicine and delivering and dispersing the medicine required by the storage type dry powder inhalation device.

5. The push-and-turn reservoir type aerosol apparatus according to claim 1, wherein the lower rail and the upper rail are sleeved on the connecting rod and coaxially matched with each other; the upper end of the connecting rod is connected with the medicine pit disc, and the lower end of the connecting rod is connected with the second ratchet wheel through the coupler;

a main gear is arranged at one end of the first ratchet wheel, a pawl is arranged on the periphery of the other end of the first ratchet wheel, and a pawl groove is arranged on the inner ring of the other end of the first ratchet wheel;

one end of the second ratchet wheel is provided with a cross shaft, and the other end of the second ratchet wheel is provided with a pawl; a runner air inlet is arranged on the runner of the device; at least one medicine pit is arranged on the medicine pit plate; the medicine storage barrel and the device flow channel are positioned and spliced into a whole by arranging at least one group of pin holes and corresponding pin shafts.

6. The push-and-twist reservoir type aerosol apparatus as claimed in claim 1, wherein the push-and-twist reservoir type aerosol apparatus is provided with a push-and-twist linkage structure to realize a 'dose division' function;

the connecting rod penetrates through the cross hole of the lower rail and the cross hole of the upper rail, so that the shaft holes are matched, and the rotating directions of the lower rail, the upper rail and the connecting rod are consistent;

the upper limit and the lower limit of the lower track and the upper track are realized through the upper shell, the cover plate and the lower shell, and after the limit is formed, a rising channel along a cylindrical surface curve is formed between the track surfaces of the lower track and the upper track;

the ascending channel and the rolling hemisphere realize a point contact mode of attachment, when the push button moves upwards along the push button slide rail, the rolling hemisphere and the push button clamping groove component move upwards along with the push button, the upper rail rotates under the action of the upward acting force of the rolling hemisphere, and the lower rail and the connecting rod rotate together due to the fact that the rotating directions of the lower rail, the upper rail and the connecting rod are consistent;

the connecting rod rotates to drive the medicine pit disc to rotate, the medicine pits on the medicine pit disc are rotated to the position of the medicine powder outlet from the lower part of the medicine storage barrel, single-dose-sucking medicines separated from the medicine storage barrel are carried in the medicine pits in the rotating process, and the function of dividing the dose is finally realized;

along with the air flow entering from the flow passage air inlet of the device flow passage, the medicine powder in the medicine pit can be entrained away and enters the flow passage space formed by the upper flow passage cavity and the lower flow passage cavity, and the medicine particles are dispersed under the action of the air flow turbulence, so that the medicine particles are inhaled into the lung of a patient.

7. The push-twist aerosol reservoir system of claim 1, wherein the interior of the drug storage barrel is a straight-through structure; the upper end face of the medicine pit plate is in fit contact with the bottom face of the medicine storage barrel, and the medicine storage barrel is sealed by the medicine barrel cover to form a closed space of the medicine storage barrel, so that the function of storing medicine powder is realized.

8. The push-twist reservoir-type aerosol apparatus according to claim 1, wherein when the push-twist moves up, the first ratchet wheel does not rotate, only the second ratchet wheel rotates, and at this time, the counter gear and the transition gear do not rotate, the number printed on the outer side of the counter gear does not change, and when the second ratchet wheel rotates to the 90-degree position, the pawl thereof is clamped into the pawl groove of the first ratchet wheel, and the pawl is compressed from deformation to release, thereby making a crisp "sound";

when the push button moves downwards, under the influence of the rotation of the connecting rod and the coupling, the second ratchet wheel rotates towards the other direction, the rotation direction of the second ratchet wheel is opposite to the direction of the pawl of the second ratchet wheel, the pawl of the second ratchet wheel pushes against the first ratchet wheel to rotate, and because the rotation direction is consistent with the direction of the pawl of the first ratchet wheel, the first pawl rotates in the process of moving downwards of the push button, the transition gear and the counting gear are driven to rotate, and the change of the number of the counter is realized; meanwhile, the first ratchet wheel rotates 90 degrees and then is clamped into the ratchet wheel clamping groove of the first ratchet wheel, and in the clamping process, the pawl of the first ratchet wheel is compressed and deformed and then released, so that a crisp 'sound' can be generated again;

by adopting the structure and the component movement mode, the push-twist storage type aerosol powder device realizes the function of voice prompt in the process of pushing, twisting and dividing the dose.

9. The push-twist dry aerosol reservoir device of claim 1, wherein the dry aerosol reservoir device is operated by the steps of:

1) a vertical holding device;

2) pushing the push button;

3) and (5) sucking the medicine.

10. The push-and-twist aerosol reservoir system of claim 9, wherein the aerosol reservoir system is operated in a push-and-twist manner, i.e., one-handed operation:

firstly, vertically holding the device by a single hand;

the second part is pushed and twisted by the thumb of the holding hand of the patient to carry out the dosage division;

thirdly, sucking the medicine by mouth;

in the above-described operation steps, the patient does not need to use the other hand to perform auxiliary holding on the device.

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