CN114224392B - Sampler and sampling equipment - Google Patents
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- CN114224392B CN114224392B CN202111398520.9A CN202111398520A CN114224392B CN 114224392 B CN114224392 B CN 114224392B CN 202111398520 A CN202111398520 A CN 202111398520A CN 114224392 B CN114224392 B CN 114224392B
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- 238000005070 sampling Methods 0.000 title claims abstract description 213
- 239000000523 sample Substances 0.000 claims abstract description 83
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000003825 pressing Methods 0.000 claims abstract description 15
- 210000001989 nasopharynx Anatomy 0.000 claims abstract description 9
- 239000013013 elastic material Substances 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims description 43
- 238000004321 preservation Methods 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims 6
- 230000007704 transition Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 description 45
- 238000010586 diagram Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 239000003761 preservation solution Substances 0.000 description 6
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 5
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 4
- 230000004308 accommodation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 241000711573 Coronaviridae Species 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010028750 Nasal oedema Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The sampler comprises a sampling probe, a telescopic piece and a sampling test tube, wherein the sampling probe is connected with the telescopic piece, the sampling test tube comprises a containing cavity, the containing cavity is provided with a first opening, the telescopic piece is arranged at the first opening and seals the containing cavity, and the telescopic piece and the sampling test tube are made of elastic materials; when the sampling test tube is in an initial state, the telescopic piece and the sampling probe are both accommodated in the accommodating cavity; when the sampling test tube is pressed, the telescopic piece drives the sampling probe to extend out of the accommodating cavity for sampling. The sampling probe is connected with the telescopic piece, and the telescopic piece can drive the sampling probe to sample by pressing the sampling test tube; the sampling test tube can be released to drive the sampling probe to retract into the sampling test tube through the telescopic piece. Because the telescopic part is flexible structure, drive sampling head sampling through the telescopic part, can reduce the sample probe to the stimulation of nasopharynx chamber in the sampling process, when having promoted the experience of taker, also improved the sampling success rate.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a sampler and sampling equipment.
Background
Nucleic acid detection plays an important role in the diagnosis process of the new coronavirus pneumonia, and in order to prevent the spread of the new coronavirus pneumonia, a plurality of cities provide national nucleic acid sample collection and detection projects. At present, nucleic acid samples are generally collected by adopting nasopharynx sampling, and the existing nasopharynx sampling reaches a nasopharynx cavity back wall sampling area through a lower nasal cavity by a hard nasopharynx swab, and because the mucous membrane tissue of the nasopharynx cavity of a human body is sensitive and weak, the hard swab is easy to stimulate the nasopharynx of the human body to cause the problems of watery nasal discharge, congestion and edema of mucous membrane and the like.
Disclosure of Invention
The invention aims to provide a sampler and sampling equipment, which can reduce the stimulation of a sampling head to a human body in the sampling process.
In order to achieve the purpose of the invention, the invention provides the following technical scheme:
In a first aspect, the invention provides a sampler, comprising a sampling probe, a telescopic member and a sampling test tube, wherein the sampling probe is connected with the telescopic member, the sampling test tube comprises a containing cavity, the containing cavity is provided with a first opening, the telescopic member is arranged at the first opening and seals the containing cavity, the sampling probe is used for moving between the inside and the outside of the containing cavity, and both the telescopic member and the sampling test tube are made of elastic materials;
The sampling test tube comprises an initial state and a sampling state, and when the sampling test tube is in the initial state, the telescopic piece and the sampling probe are both accommodated in the accommodating cavity; in the process of switching the sampling test tube from the initial state to the sampling state, the sampling test tube is pressed, and the telescopic piece stretches out of the accommodating cavity so that the sampling probe stretches out of the accommodating cavity to sample.
In one embodiment, one end of the expansion piece is in the first opening part and is connected with the sampling test tube, the sampling test tube still includes the save state, the sampling test tube is followed the sampling state switches over to the in-process of save state, the pressure of sampling test tube is released, sampling probe withdrawal accommodation chamber when the save state, the expansion piece encloses an accommodation groove, sampling probe set up in the inner wall of accommodation groove.
In one embodiment, the sampler further comprises a liquid storage bottle, the liquid storage bottle comprises a second opening, the liquid storage bottle is connected with the sampling test tube in the preservation state, the second opening is communicated with the first opening, and preservation liquid is injected into the accommodating groove from the liquid storage bottle.
In one embodiment, the diameter of the second opening is larger than that of the first opening, and the liquid storage bottle is provided with a sealing film at the second opening, and the sealing film is punctured in the preservation state.
In one embodiment, the sealing film and the liquid storage bottle are arranged at an included angle on a plane parallel to the second opening, and in the preservation state, one side of the sealing film, which is close to the sampling test tube, is damaged.
In one embodiment, the liquid storage bottle has elasticity, and when the liquid storage bottle is pressed, the sealing film is broken.
In one embodiment, a sealing ball is disposed at the second opening, and in the storage state, the sampling tube pushes the sealing ball into the liquid storage bottle.
In an embodiment, the sampler further comprises a fixing part, the fixing part is arranged in the accommodating cavity, the fixing part comprises a first end and a second end, the first end is connected with the sampling probe, the second end is fixedly connected with the sampling test tube, and the fixing part pulls the sampling probe back into the accommodating cavity in the process of switching the sampling test tube from the sampling state to the preservation state.
In one embodiment, the telescoping member is provided with a depth marking for marking the length of the sampling probe extending out of the receiving cavity.
In a second aspect, the present invention further provides a sampling apparatus, including a controller, a pressing device and a sampler according to any embodiment of the first aspect, where the pressing device is used to apply pressure to a sampling tube of the sampler, and the controller is electrically connected to the pressing device to control the magnitude of the pressure.
The telescopic piece is arranged in the sampler, the sampling probe is connected with the telescopic piece, and the telescopic piece can be stretched by pressing the sampling test tube so as to drive the sampling probe to sample; the sampling test tube can be released to retract to the sampling test tube by the telescopic piece to drive the sampling probe. Because the telescopic part is flexible structure, drive sampling head sampling through the telescopic part, reduced the sampling in-process effectively, sampling probe has improved the experience of taker in the stimulation of nasopharyngeal cavity, also improved the sampling success rate.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a sampler according to one embodiment;
FIG. 2 is a schematic diagram of the structure of a sampling tube according to one embodiment;
FIG. 3 is a schematic diagram of a sampler according to another embodiment;
FIG. 4 is a schematic structural view of a sealing film according to an embodiment;
FIG. 5 is a schematic diagram of a sampler according to another embodiment;
FIG. 6 is a schematic diagram of a sampler according to another embodiment;
FIG. 7 is a schematic diagram of a sampler according to another embodiment;
FIG. 8 is a schematic diagram of the sampler shown in FIG. 7 in a storage state;
Fig. 9 is a schematic structural diagram of a sampling device according to an embodiment.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1 and 2, the present invention provides a sampler, which includes a sampling probe 10, a telescopic member 20 and a sampling test tube 30, wherein the sampling probe 10 is connected with the telescopic member 20, the sampling test tube 30 includes a housing cavity 31, the housing cavity 31 is provided with a first opening 32, the telescopic member 20 is disposed at the first opening 32 and seals the housing cavity 31, the sampling probe 10 is used for moving between the inside and the outside of the housing cavity 31, and both the telescopic member 20 and the sampling test tube 30 are made of elastic materials.
In this embodiment, the sampling probe 10 is a swab made of non-cotton material such as polyester, nylon, or the like, or non-calcium alginate material, such as a flocked head swab, which has a very soft material, so as to reduce the irritation to the collected sample, and also has a characteristic of completely and rapidly releasing the sample. The extensible member 20 is made of a film structure made of a flexible material with high stability, the flexible material can be TPU (Thermoplastic Polyurethanes, thermoplastic polyurethane elastomer rubber), and the extensible member 20 is made of a material with high stability, so that chemical reaction between the extensible member 20 and human mucous membrane in the sampling process is avoided, and substance residues are caused to influence human health. At the same time, the high water and moisture permeability of the TPU can better seal the receiving chamber 31, thereby having a better sealing effect on the receiving chamber 31.
Similarly, the sampling tube 30 may also be made of TPU. The sampling tube 30 includes an initial state and a sampling state, and when the sampling tube 30 is in the initial state, both the bellows 20 and the sampling probe 10 are accommodated in the accommodating chamber 31. In the process of switching the sampling test tube 30 from the initial state to the sampling state, the sampling test tube 30 is pressed and deformed, so that gas in the accommodating cavity 31 is compressed, the gas pressure in the accommodating cavity 31 is larger than the external gas pressure, the telescopic piece 20 is pressed and deformed and stretches out of the accommodating cavity 31, and meanwhile, the sampling probe 10 is driven to stretch out of the accommodating cavity 31 so as to sample a patient.
The sampling tube 30 further comprises a preservation state, when sampling is completed, the sampling tube 30 is switched from the sampling state to the preservation state to preserve a sample, in the process, the pressure applied to the sampling tube 30 is released, the sampling tube 30 is restored to the initial state, the air pressure in the accommodating cavity 31 is less than or equal to the external air pressure, the telescopic piece 20 is retracted into the accommodating cavity 31, and the sampling probe 10 is driven to be retracted into the accommodating cavity 31. The purpose of collecting and preserving the sample can be achieved by switching the sampling tube 30 between the sampling state and the preserving state.
The telescopic piece 20 is arranged in the sampler, the sampling probe 10 is connected with the telescopic piece 20, and the telescopic piece 20 can be stretched by pressing the sampling test tube 30 so as to drive the sampling probe 10 to sample; releasing the sampling tube 30 can retract the sampling probe 10 into the sampling tube 30 by retracting the telescoping member 20. Because the telescopic piece 20 is flexible structure, the sampling head 10 is driven to sample through the telescopic piece 20, so that the stimulus of the sampling probe 10 to the nasopharyngeal cavity in the sampling process is effectively reduced, the experience of a person to be sampled is improved, and the sampling success rate is also improved.
In one embodiment, referring to fig. 1, one end of the telescopic member 20 is connected to the sampling tube 30 at the first opening 32, and when the sampling tube 30 is in the storage state, the telescopic member 20 encloses a receiving groove 21, and the sampling probe 10 is disposed on an inner wall of the receiving groove 21. When the sampling tube 30 is compressed, the expansion member 20 extends out of the accommodating chamber 31, and at this time, the surface of the sampling probe 10 facing away from the expansion member 20 is in contact with the subject, which is favorable for full contact with the nasopharynx, so that the sampling is completed rapidly.
In addition, the sampler further includes a liquid storage bottle 40, the liquid storage bottle 40 includes a second opening 41, when the sampling probe 10 finishes sampling, the liquid storage bottle 40 is connected with the sampling test tube 30, and at this time, the second opening 41 is communicated with the first opening 32, and the liquid storage bottle 40 injects the preservation liquid into the accommodating groove 21. By arranging the sampling probe 10 on the inner wall of the accommodating groove 21, the sampling probe 10 is advantageously completely immersed in the preservation solution after the preservation solution is injected into the accommodating groove 21, so that the sample on the sampling probe 10 can be better preserved.
In one embodiment, referring to fig. 1, 3 and 4, the diameter of the second opening 41 is larger than the diameter of the first opening 32. The liquid storage bottle 40 is provided with a sealing film 50 at the second opening 41 to store preservation liquid in the liquid storage bottle 40. The sealing film 50 can be made of plastic with high stability, and can be made into a film shape enough to be easily damaged by compression, and has the characteristic of being not easy to be dissolved by chemical reaction, so that the sealing film can not be chemically reacted with preservation liquid to realize sealed preservation of the preservation liquid. When the sampling probe 10 finishes sampling, the liquid storage bottle 40 is inverted with the second opening 41 opposite to the first opening 32, and then pressure in the direction toward the sampling test tube 30 is applied to the liquid storage bottle 40 so that the second opening 41 is fitted around the outer periphery of the first opening 32. As shown in fig. 4, the sealing film 50 is provided with a notch 51, the diameter of the notch 51 is equal to that of the first opening 32, so that when the liquid storage bottle 40 and the sampling test tube 30 are mounted, the sampling test tube 30 applies pressure to the notch 51 to break the notch 51, the sealing film 50 is punctured, at this time, the liquid storage bottle 40 is communicated with the sampling test tube 30, and the preserving liquid in the liquid storage bottle 40 is injected into the containing groove 21 to submerge the sampling probe 10, thereby preserving the sample. In other embodiments, score 51 may have other shapes, such as a cross shape, etc. By providing the sealing film 50 at the second opening 41 of the liquid storage bottle 40, the sealing film 50 can seal the second opening 41 before the sampling of the sampler is completed, thereby realizing the sealing preservation effect on the preservation liquid. When the sampling is completed, the preservation solution can be injected into the accommodating groove 21 only by installing the liquid storage bottle 40 and the sampling test tube 30, so that the preservation of the sample is realized, the operation process of sample preservation is simplified, and the sampling efficiency is improved.
It will be appreciated that this embodiment is described by taking the liquid storage bottle 40 and the sampling tube 30 as cylindrical bodies, and the dimensions of the first opening 32 and the second opening 41 are indicated by diameters. In other embodiments, the liquid storage bottle 40 and the sampling tube 30 may have any other shape such as a rectangular parallelepiped, and the present embodiment is not limited specifically.
In one embodiment, referring to fig. 4 and 5, the liquid storage bottle 40 has elasticity, and the sealing film 50 is broken when the liquid storage bottle 40 is pressed. In this embodiment, the liquid storage bottle 40 includes a sidewall made of an elastic material, and when pressure is applied to the liquid storage bottle 40, the sidewall is elastically deformed to compress air in the bottle, and the pressure in the liquid storage bottle 40 becomes large to apply pressure to the sealing film 50. Similarly, the seal film 50 is provided with a score 51, which is easily broken by pressure due to a relatively thin thickness, so that the preserving fluid in the reservoir 40 is injected into the receiving groove 21. Through making stock solution bottle 40 have elasticity, only need press stock solution bottle 40 can make sealing film 50 damaged to reach the purpose of pouring into holding tank 21 with preserving fluid, when simple structure, the operation is also convenient and fast more, has improved sampling efficiency.
In one embodiment, referring to fig. 6, the sealing film 50 and the liquid storage bottle 40 are disposed at an included angle on a plane parallel to the second opening 41, and a communicating portion 52 is disposed on a side of the sealing film 50 near the sampling test tube 30, where the communicating portion 52 is used to support the sampling test tube 30; the side away from the sampling tube 30 is a fixing portion 53, and the fixing portion 53 is used for fixing the sealing film 50 on the liquid storage bottle 40. In the storage state, the communication portion 52 is broken by the holding of the sampling tube 30, and communicates the liquid storage bottle 40 with the storage tank 21, so that the storage liquid is injected into the storage tank 21. At this time, the fixing portion 53 and the sampling tube 30 remain in an unconnected state and remain intact, so that the sealing film 50 is prevented from falling into the accommodating groove 21 after being broken, which is advantageous for ensuring sufficient contact between the sample and the preserving fluid.
In an embodiment, referring to fig. 7 and 8, the liquid storage bottle 40 includes a second opening 41, and a sealing ball 60 is disposed at the second opening 41, where the sealing ball 60 is made of a material with strong stability, so as to ensure that the sealing ball cannot react with the preservation solution to cause the preservation solution to be polluted. The sealing ball 60 has a diameter greater than or equal to the diameter of the second opening 41 to engage with the second opening 41, thereby sealing the second opening 41. And the maximum size of the sealing ball 60 exposed to the outside of the second opening 41 is larger than that of the first opening 32, when the sampler is in a storage state, the sampling tube 30 and the liquid storage bottle 40 are relatively moved to enable the sampling tube 30 to abut against the sealing ball 60, so that pressure towards the inside of the liquid storage bottle 40 is applied to the sealing ball 60 until the sealing ball 60 leaves the second opening 41 to enter the inside of the liquid storage bottle 40, at this time, the second opening 41 is communicated with the first opening 32, and storage liquid is injected into the containing groove 21 through the second opening 41. Through setting up sealing ball 60 in second opening 41 department to design sealing ball 60's size, when preserving the sample, only need make stock solution bottle 40 and sampling test tube 30 relative motion, can realize the intercommunication of stock solution bottle 40 and holding tank 21, reach the purpose of injecting into holding tank 21 with the preservation solution, simplified the structure of sampler, and easy operation has improved sampling efficiency.
In one embodiment, referring to fig. 1, the sampler further includes a fixing member 70, where the fixing member 70 is disposed in the accommodating cavity 31, and the fixing member 70 has elasticity, such as an elastic pull rope, a spring, and the like. The fixing member 70 includes a first end 71 and a second end 72, the first end 71 being connected to the sampling probe 10, and the second end 72 being fixed to the inner wall of the sampling tube 30 remote from the telescopic member 20. In this embodiment, the sampling tube 30 comprises a bottom wall 33, the bottom wall 33 being remote from the inner wall of the bellows 20, and the second end 72 being fixed to the bottom wall 33. When the fixing member 70 is in the initial state, the length thereof is equal to the distance between the sampling probe 10 and the bottom wall of the sampling tube 30 when the sampling tube 30 is in the initial state; when the sampling probe 10 is in the sampling state, the first end 71 of the fixing member 70 is stretched to be elastically deformed and elongated; when the sampling probe 30 is switched from the sampling state to the storage state, the fixing member 70 applies a pulling force to the sampling probe 10 toward the side of the bottom wall 33 through the first end 71 to retract the sampling probe 10 into the accommodating chamber 31, and the second end 72 is fixed to the bottom wall 33, thereby achieving the purpose of fixing the sampling probe 10 in the accommodating chamber 31. By arranging the elastic fixing piece 70 in the sampling test tube 30, the sampling probe 10 can be effectively ensured to retract into the accommodating cavity 31 after sampling is completed, and the preservation of a sample is facilitated.
In one embodiment, referring to FIG. 2, the telescoping member 20 is provided with a depth indicator 22, the depth indicator 22 being used to mark the length of the sampling probe 10 extending out of the receiving cavity 31. The depth mark 21 may be a scale, and the position of the sampling probe 10 can be known through direct reading. Or may be known by other forms of label conversion. In addition, the depth indicator 22 can be set according to the pressure applied to the sampling tube 30, so that the corresponding pressure can be applied to the sampling tube 30 according to the length of the telescopic member 20.
Referring to fig. 1 and 9, an embodiment of the present invention further provides a sampling apparatus including the sampler, the controller 200, and the pressing device 300 provided in any of the above embodiments. Specifically, the sampling device further comprises a carrying stage 400, the carrying stage 400 being adapted to carry the sampling tube 30. The pressing device 300 is arranged on the carrying table and comprises two clamping plates 301 which can move relatively, the two clamping plates 301 are respectively arranged on two opposite sides of the sampling test tube 30, and when pressure needs to be applied to the sampling test tube 30 of the sampler, the two clamping plates 301 move relatively to press the sampling test tube 30. In addition, the controller 200 is electrically connected with the pressing device 300, and the controller 200 can control the pressure applied by the pressing device 300 to the sampler according to the length of the probe 10 extending to the accommodating cavity 31, and the relation between the length and the pressure can be measured in advance and stored in the program of the controller. For example, when the sampling probe 10 is required to extend 20cm, the required pressure is 2N, and the controller 200 can control the pressing device 300 to apply a force of 2N to the sampling tube 30, so as to further control the sampling probe 10 to extend 20 cm. In this embodiment, the amount of pressure can be controlled by controlling the distance the two clamping plates 301 move. It is to be understood that in other embodiments, the pressing device 300 may have other structures, and the embodiment is not limited specifically. By adopting the sampler, the controller 200 and the pressing device 300 provided by the embodiment of the invention in the sampling equipment, the control of the extension length of the sampling probe 10 can be realized, the stimulation to the human body caused by the propping of the sampling head and the nasopharyngeal cavity in the sampling process can be reduced, the experience of a person to be sampled is improved, and the sampling success rate is also improved.
The above disclosure is only a preferred embodiment of the present invention, and it should be understood that the scope of the invention is not limited thereto, and those skilled in the art will appreciate that all or part of the procedures described above can be performed according to the equivalent changes of the claims, and still fall within the scope of the present invention.
Claims (10)
1. The sampler is characterized by comprising a sampling probe, a telescopic piece and a sampling test tube, wherein the sampling probe is connected with the telescopic piece, the sampling test tube comprises a containing cavity, the containing cavity is provided with a first opening, the telescopic piece is arranged at the first opening and seals the containing cavity, the sampling test tube further comprises a bottom wall, the bottom wall is positioned at one end of the sampling test tube opposite to the first opening, a gap is reserved between the telescopic piece and the bottom wall, the sampling probe is used for moving between the inside and the outside of the containing cavity, and the telescopic piece and the sampling test tube are made of elastic materials;
The sampling test tube comprises an initial state and a sampling state, and when the sampling test tube is in the initial state, the telescopic piece and the sampling probe are both accommodated in the accommodating cavity; the sampling test tube is switched to the in-process of sampling state from initial state, the sampling test tube is pressed, the expansion piece stretches out hold the chamber, so that the sampling probe stretches out hold the chamber and be used for stretching into the nasopharynx chamber and sampling, in order to be used for carrying out nucleic acid detection.
2. The sampler of claim 1, wherein one end of the telescoping member is connected to the sampling tube at the first opening, the sampling tube further comprises a storage state, the pressing force of the sampling tube is released during the process of switching from the sampling state to the storage state, the sampling probe is retracted into the accommodating cavity, and the telescoping member encloses an accommodating groove in the storage state, and the sampling probe is disposed on the inner wall of the accommodating groove.
3. The sampler of claim 2, further comprising a reservoir bottle, the reservoir bottle comprising a second opening, the reservoir bottle being connected to the sampling tube in the storage state, the second opening being in communication with the first opening, the reservoir bottle injecting a preservation fluid into the receptacle.
4. A sampler according to claim 3, wherein the diameter of the second opening is greater than the diameter of the first opening, the reservoir being provided with a sealing membrane at the second opening, the sealing membrane being broken in the stored condition.
5. The sampler of claim 4, wherein said sealing membrane is disposed at an angle to said reservoir in a plane parallel to said second opening, and wherein said sealing membrane is broken on a side of said sealing membrane adjacent said sampling tube in said storage state.
6. The sampler of claim 4, wherein the reservoir has elasticity, and the sealing membrane breaks when the reservoir is pressed.
7. A sampler according to claim 3, wherein the second opening is provided with a sealing ball, and in the stored state the sampling tube pushes the sealing ball into the reservoir.
8. The sampler of claim 2, further comprising a securing member disposed within the receiving chamber, the securing member comprising a first end and a second end, the first end being coupled to the sampling probe and the second end being fixedly coupled to the sampling tube, the securing member pulling the sampling probe back into the receiving chamber during the transition of the sampling tube from the sampling state to the storage state.
9. The sampler of claim 1, wherein the telescoping member is provided with a depth indicator for marking the length of the sampling probe extending out of the receiving chamber.
10. A sampling device comprising a controller, a pressure applicator for applying pressure to a sampling tube of the sampler, and a sampler according to any one of claims 1 to 9, the controller being electrically connected to the pressure applicator to control the magnitude of the pressure.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111398520.9A CN114224392B (en) | 2021-11-23 | 2021-11-23 | Sampler and sampling equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111398520.9A CN114224392B (en) | 2021-11-23 | 2021-11-23 | Sampler and sampling equipment |
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| Publication Number | Publication Date |
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| CN114224392A CN114224392A (en) | 2022-03-25 |
| CN114224392B true CN114224392B (en) | 2024-06-18 |
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| CN202111398520.9A Active CN114224392B (en) | 2021-11-23 | 2021-11-23 | Sampler and sampling equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106413571A (en) * | 2014-06-10 | 2017-02-15 | 柳尚永 | Device and method for self-collecting vaginal sample for human papilloma virus examination |
| CN211665079U (en) * | 2019-11-27 | 2020-10-13 | 郑州华之源医学检验实验室有限公司 | Gene detection sampler |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3356782B2 (en) * | 1996-05-17 | 2002-12-16 | アミラ メディカル | Disposable element used in a device for sampling body fluids |
| CA2845317A1 (en) * | 2011-08-04 | 2013-02-07 | The Regents Of The University Of California | Saliva collection, processing, stabilization, and storage method |
| CN213283056U (en) * | 2020-04-24 | 2021-05-28 | 天津渤海农牧产业联合研究院有限公司 | Pharyngeal sampler |
| US20210345994A1 (en) * | 2020-05-11 | 2021-11-11 | MS Pen Technologies, Incorporated | Biological Sampling Apparatus |
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2021
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106413571A (en) * | 2014-06-10 | 2017-02-15 | 柳尚永 | Device and method for self-collecting vaginal sample for human papilloma virus examination |
| CN211665079U (en) * | 2019-11-27 | 2020-10-13 | 郑州华之源医学检验实验室有限公司 | Gene detection sampler |
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