CN114224318A - Small animal plethysmograph case under high pressure - Google Patents
Small animal plethysmograph case under high pressure Download PDFInfo
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- CN114224318A CN114224318A CN202111540826.3A CN202111540826A CN114224318A CN 114224318 A CN114224318 A CN 114224318A CN 202111540826 A CN202111540826 A CN 202111540826A CN 114224318 A CN114224318 A CN 114224318A
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- 241001465754 Metazoa Species 0.000 title claims abstract description 35
- 238000012360 testing method Methods 0.000 claims abstract description 35
- 239000000443 aerosol Substances 0.000 claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 238000005192 partition Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000007246 mechanism Effects 0.000 claims description 91
- 230000005540 biological transmission Effects 0.000 claims description 23
- 230000001681 protective effect Effects 0.000 claims description 19
- 239000003381 stabilizer Substances 0.000 claims description 16
- 238000003825 pressing Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 239000000741 silica gel Substances 0.000 claims description 10
- 229910002027 silica gel Inorganic materials 0.000 claims description 10
- 230000001360 synchronised effect Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 2
- 238000010030 laminating Methods 0.000 abstract description 7
- 208000002193 Pain Diseases 0.000 abstract description 3
- 238000005070 sampling Methods 0.000 abstract description 3
- 239000003570 air Substances 0.000 description 13
- 230000006872 improvement Effects 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 208000035209 Ring chromosome 17 syndrome Diseases 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 208000035210 Ring chromosome 18 syndrome Diseases 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000006837 decompression Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0806—Detecting, measuring or recording devices for evaluating the respiratory organs by whole-body plethysmography
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- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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Abstract
The invention discloses a small animal volume tracing box under high pressure, which comprises an exhaust support, an auxiliary device, a shell, a conversion block, a connecting pipe, a top cover, a test cavity pneumotach, a reference cavity pneumotach, an aerosol manifold, a partition board, a reference cavity, a test cavity, an anti-biting structure, a water sampling pipe, a supporting plate, supporting legs, an embedding ring, a silica gel ring, a clamping groove and an embedded groove, wherein the embedded ring is arranged at the bottom of the top cover, the silica gel ring is arranged on the inner side of the top cover and is matched with the clamping groove at the upper end in the shell and the embedded groove at the upper end of the inner side of the top cover, so that the stability during connection is improved, the airtightness is good after connection, and the integral airtightness is improved; be equipped with in aerosol manifold bottom and prevent stinging the structure, prevent stinging structure upper end and be connected with the aerosol manifold through flexible laminating cover, and fixed ring is connected to flexible laminating cover bottom, and fixed ring bottom is equipped with the protection network, and the protection network is the rigidity, and the effectual protection network of avoiding being bitten by the white mouse bite.
Description
Technical Field
The invention relates to the field of plethysmographs, in particular to a small animal plethysmograph box under high pressure.
Background
Plethysmographs are used for research purposes to collect data relating to the change in air pressure within a test chamber, an example of which is lung data from a small animal such as a mouse, most plethysmographs comprise a test chamber enclosing the test subject, a reference chamber and a differential pressure transducer connected to the two chambers, for example via a tube extending from a port in each chamber to the transducer, the two chambers being in communication with the ambient air (i.e. the air within the room being tested) through a restricted airflow opening or pneumotach.
In the actual use process of the conventional WBP volume tracing box, the conventional WBP volume tracing box is used under normal pressure, and when the WBP volume tracing box under normal pressure is put into a high-pressure cabin for use, the air pressure cannot realize rapid balance due to relative sealing in the volume tracing box in the pressure increasing and reducing stage; the too large pressing depth and the too high speed can cause the damage of the mechanical structure of the volume drawing box, and the measurement is inaccurate; in the pressure stabilizing stage, the pressure of the volume tracing box is gradually increased, and when high-pressure exposure is completed and pressure reduction is carried out to press the volume out of the cabin, if the pressure reduction is too fast, the mechanical structure of the volume tracing box can be damaged, so that measurement deviation is caused; when the volume tracing box is separated from a high-pressure environment, the pressure of the volume tracing box can be balanced after a long time; the air tightness of the top cover is poor, and the aerosol manifold is easily bitten by a white mouse when being arranged inside, so that the damage is caused; the top cap is not convenient for the dismouting, leads to the mice to put into inconveniently, needs artifical supplementary dismouting to put into, and automatic effect is relatively poor.
Disclosure of Invention
Accordingly, to address the above-described deficiencies, the present invention herein provides a small animal plethysmograph chamber at high pressure.
The invention is realized in such a way that a high-pressure small animal volume tracing box is constructed, the device comprises an exhaust support, the front end in the exhaust support is provided with an exhaust port, the upper end in the exhaust support is provided with a shell, the upper end of the front end surface of the shell is provided with a conversion block, the front end of the conversion block is embedded with a connecting pipe, the top of the shell is provided with a top cover, the left end and the right end of the top cover are respectively provided with a test cavity pneumotach and a reference cavity pneumotach, the middle part of the top end of the shell is embedded with an aerosol manifold, the upper end of the inner side of the shell is provided with a partition board which separates the upper end and the lower end in the shell, the upper end is a reference cavity, the lower end is a test cavity, the bottoms of the test cavity pneumotach and the reference cavity pneumotach are respectively communicated with the interiors of the test cavity and the reference cavity through branch pipes, and the connecting positions of the tops of the branch pipes with the test cavity pneumotach and the reference cavity pneumotach are provided with a fine filter screen, the bottom of the aerosol manifold penetrates through a partition plate to be communicated with a test cavity, a supporting plate is arranged at the lower end in the test cavity, the bottom of the supporting plate is arranged at the upper end in an exhaust support through a supporting leg, the upper left end of the test cavity is communicated with a water sampling pipe, two groups of connecting pipes are arranged in the conversion block, the insides of the two groups of connecting pipes are respectively communicated with a reference cavity and the inside of the test cavity, the outer side of the exhaust support is connected with an auxiliary device, the bottom of the aerosol manifold is connected with an anti-biting structure, an embedded ring is fixed at the bottom of a top cover, the lower end of the inner side of the top cover is attached with the embedded ring, a clamping groove is formed in the upper end of the inner side of a shell, the inner end of the shell is fixedly provided with an embedded groove, the silica gel ring is arranged in the embedded groove, the connecting pipe in the conversion block is connected with a three-way joint through an external pipeline, and the other end of the three-way joint is connected with a differential pressure converter, the utility model discloses an aerosol manifold, including three way connection, pressure stabilizer, pressure difference converter, amplifier, fixed ring, protection network, aerosol manifold, fixed ring, protection network, protective ring, three way connection, pressure stabilizer, pressure difference converter, fixed ring, protection network and go-between, the structure of preventing stinging includes flexible laminating cover, fixed ring, protection network and go-between, the flexible laminating cover outside bonds with the inboard lower extreme of aerosol manifold, flexible laminating cover bottom is fixed with fixed ring, the fixed ring outside meets with the go-between through the protection network.
The auxiliary device comprises a side plate, a sliding mechanism, a first motor, a cover taking mechanism, a clamping adjusting mechanism, a second motor and a hand wheel, wherein the sliding mechanism is installed at the rear end of the inner side of the side plate, the first motor is arranged at the back of the sliding mechanism, the cover taking mechanism is arranged at the top of the sliding mechanism, the clamping adjusting mechanism is arranged at the inner front end of the side plate, the second motor is installed at the rear end of the outer side of the clamping adjusting mechanism, and the hand wheel is arranged at the front end of the outer side of the clamping adjusting mechanism.
Slide mechanism includes box, spout, guide way, threaded rod, slider and guide block, the box both sides are fixed with the curb plate, the spout has been seted up at box top middle part, the guide way has been seted up at box top both ends, the middle part is equipped with the threaded rod in the box, the threaded rod outside is equipped with the slider, the slider top is run through the spout top and is met with the mechanism of taking the lid, the inside activity embedding of guide way has the guide block, the guide block top meets with the mechanism of taking the lid.
Get and cover mechanism and include support, cylinder, support, spring leaf and silica gel layer, the support bottom meets with guide block and slider top respectively, the cylinder is installed to support outside upper end, the inboard ejector pin of cylinder runs through the support upper end and meets with support, support the inboard spring leaf that is equipped with of piece, the inboard bonding of spring leaf has the silica gel layer.
The clamping adjusting mechanism comprises a fixed box, an intermittent mechanism, a linkage shaft, a transmission box, a driving belt wheel, a synchronous belt, a driven belt wheel, a slide bar, a screw and a pressing plate, the inner side of the fixed box is connected with the side plate, the fixed box is internally provided with an intermittent mechanism, the rear end of the outer side of the fixed box is connected with a second motor, the front end of the inner side of the intermittent mechanism penetrates through the inner side of the side plate through the linkage shaft, the inner side of the side plate is provided with a transmission case, the rear end in the transmission case is provided with a driving belt wheel, the middle part in the driving belt wheel is connected with a linkage shaft, the outer side of the driving belt wheel synchronously rotates with the driven belt wheel through a synchronous belt, the middle part in the driven belt wheel is connected with the sliding rod, the right side of the sliding rod is arranged in the side plate and is connected with a screw rod, the screw rod is in threaded connection with the inner part of the side plate, the outer side of the screw rod is connected with a hand wheel, and the inner side of the sliding rod is contacted with the exhaust support through a pressing plate.
The intermittent mechanism comprises a chassis, a connecting shaft, a rotating wheel, a stirring column, an intermittent wheel and a transmission shaft, wherein the inner side of the chassis is connected with the fixed box, the upper end of the outer side of the chassis is provided with the connecting shaft, the outer side of the connecting shaft is connected with an output shaft of a second motor, the connecting shaft is connected with the inner part of the rotating wheel, the lower end of the outer side of the rotating wheel is provided with the stirring column, the outer side of the stirring column is connected with the intermittent wheel, the middle part of the intermittent wheel is provided with the transmission shaft, and the inner side of the transmission shaft is connected with the universal driving shaft.
The surface of the protective net is smooth, and the protective net is rigid.
The middle part is turned with the internal thread in the slider to the threaded rod carries out threaded connection with the inside middle part of slider.
The lower end of the outer side of the supporting part is fixedly provided with a guide rod, and the outer side of the guide rod is movably embedded into the lower end of the support.
The inner side of the driven belt wheel is provided with convex teeth, the outer side of the sliding rod is provided with a slot, and the inner side of the driven belt wheel is meshed with the outer side of the sliding rod.
The invention has the following advantages: the invention provides a small animal plethysmograph box under high pressure through improvement, compared with the same type of equipment, the improvement is as follows:
the method has the advantages that: according to the small animal volume tracing box under high pressure, the embedded ring is arranged at the bottom of the top cover, the silica gel ring is arranged on the inner side of the top cover and is matched with the clamping groove at the upper end in the shell and the embedded groove at the upper end of the inner side of the top cover, the stability during connection is improved, the airtightness is good after connection, and the integral airtightness is improved.
The method has the advantages that: according to the small animal volume tracing box under high pressure, the anti-biting structure is arranged at the bottom of the aerosol manifold, the upper end of the anti-biting structure is connected with the aerosol manifold through the flexible laminating sleeve, the bottom of the flexible laminating sleeve is connected with the fixing ring, the bottom of the fixing ring is provided with the protective net, and the protective net is rigid and effectively prevented from being bitten by a white mouse.
The method has the advantages that: according to the small animal volume tracing box under high pressure, the outer side of the exhaust support is connected with the auxiliary device, the clamping adjusting mechanism is arranged in the auxiliary device, the independent hand wheel is arranged in the clamping adjusting mechanism, and the pressing and clamping of the exhaust support by the pressing plate on the inner side can be realized under the rotation of the hand wheel.
The advantages are that: according to the small animal plethysmograph box under high pressure, the clamping adjusting mechanism is internally provided with the intermittent mechanism, the intermittent mechanism is driven by the motor, and the angle of the whole device can be adjusted in the clamping process through transmission of the belt pulley set under the driving of the intermittent mechanism.
The advantages are that: according to the small animal volume tracing box under high pressure, the sliding mechanism is arranged at the rear end of the auxiliary device, the top of the sliding mechanism is connected with the cover taking mechanism, the cover taking mechanism can be driven to move back and forth under the driving of the sliding mechanism, the cover taking mechanism is enabled to displace when the sliding mechanism is matched with the shell with the adjusted angle, the top cover is clamped by utilizing the driving of the air cylinder, the top cover can be taken out, the small white mouse can conveniently enter after being taken out, the operation is convenient, manual operation is not needed, and the automation effect is good.
The method has the advantages that: according to the small animal plethysmograph box under high pressure, the three-way joint is arranged on the connecting pipeline between the connecting pipe and the external differential pressure converter, the other end of the three-way joint is connected with the pressure stabilizer, the pressure stabilizer can be in butt joint with external control equipment to set a pressure threshold, and the opening of the three-way joint is controlled in the processes of pressurization, pressure stabilization and pressure reduction, so that the pressure stabilizer realizes pressure relief according to the pressure threshold, the speed of pressure rising and pressure reduction is effectively controlled, the control and the stability of the internal pressure rising and falling process are realized, the damage of an internal mechanical structure caused by pressure is avoided, and the pressure balance is stably and quickly realized after the high pressure is separated.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is a schematic view of a partial connection structure of the top cover of the present invention;
FIG. 4 is a schematic view of the bite-preventing structure of the present invention;
FIG. 5 is a schematic view of the auxiliary device of the present invention;
FIG. 6 is a schematic view of the sliding mechanism of the present invention;
FIG. 7 is a schematic view of the lid removing mechanism of the present invention;
FIG. 8 is a schematic view of the clamping adjustment mechanism of the present invention;
FIG. 9 is a schematic view of the intermittent mechanism of the present invention;
fig. 10 is a block diagram of the pressure stabilizer connection of the present invention.
Wherein: an exhaust support-1, an auxiliary device-2, a shell-3, a conversion block-4, a connecting pipe-5, a three-way joint-51, a pressure stabilizer-52, a top cover-6, a test cavity pneumotacheometer-7, a reference cavity pneumotacometer-8, an aerosol manifold-9, a partition-10, a reference cavity-11, a test cavity-12, an anti-bite structure-13, a water production pipe-14, a supporting plate-15, a supporting leg-16, an embedded ring-17, a silica gel ring-18, a clamping groove-19, an embedded groove-20, a flexible attaching sleeve-131, a fixed ring-132, a protective net-133, a connecting ring-134, a side plate-21, a sliding mechanism-22, a first motor-23, a cover taking mechanism-24, a clamping and adjusting mechanism-25, a clamping adjusting mechanism, The device comprises a second motor-26, a hand wheel-27, a box body-221, a sliding groove-222, a guide groove-223, a threaded rod-224, a sliding piece-225, a guide block-226, a support-241, a cylinder-242, a supporting piece-243, a spring piece-244, a silica gel layer-245, a fixed box-251, an intermittent mechanism-252, a linkage shaft-253, a transmission box-254, a driving pulley-255, a synchronous belt-256, a driven pulley-257, a sliding rod-258, a screw rod-289, a pressing plate-2510, a chassis-2521, a connecting shaft-2522, a rotating wheel-2523, a toggle column-2524, an intermittent wheel-2525 and a transmission shaft-2526.
Detailed Description
The present invention will be described in detail with reference to fig. 1 to 10, and the technical solutions in the embodiments of the present invention will be clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
Referring to fig. 1, 2 and 3, the invention provides a high-pressure small animal plethysmograph box by improvement, which comprises an exhaust support 1, an exhaust port 2 is arranged at the front end in the exhaust support 1, a shell 3 is arranged at the upper end in the exhaust support 1, a conversion block 4 is arranged at the upper end of the front end surface of the shell 3, a connecting pipe 5 is embedded at the front end of the conversion block 4, a top cover 6 is arranged at the top of the shell 3, a test chamber pneumotach 7 and a reference chamber pneumotach 8 are respectively arranged at the left and right ends of the top cover 6, an aerosol manifold 9 is embedded in the middle of the top end of the shell 3, a partition plate 10 is arranged at the upper end of the inner side of the shell 3, the partition plate 10 separates the upper end and the lower end of the shell 3, the upper end is a reference chamber 11, the lower end is a test chamber 12, the bottoms of the test chamber pneumotach 7 and the reference chamber pneumotach 8 are respectively communicated with the test chamber pneumotach 12 and the reference chamber pneumotach 8 through branch pipes, fine filter screens are arranged at the connecting positions of the tops of the branch pipes and the reference chamber pneumotach 8, the bottom of an aerosol manifold 9 penetrates through a partition plate 10 to be communicated with a test cavity 12, the lower end in the test cavity 12 is provided with a supporting plate 15, the bottom of the supporting plate 15 is arranged at the upper end in an exhaust support 1 through a supporting leg 16, the upper left end of the test cavity 12 is communicated with a water sampling pipe 14, two groups of connecting pipes 5 are arranged in a conversion block 4, the interiors of the two groups of connecting pipes 5 are respectively communicated with a reference cavity 11 and the interior of the test cavity 12, the connecting pipe 5 in the conversion block 4 is connected with a differential pressure converter through an external pipeline, the differential pressure converter is butted with a recorder through an amplifier, the outer side of the exhaust support 1 is connected with an auxiliary device 2, the bottom of the aerosol manifold 9 is connected with an anti-biting structure 13, the bottom of a top cover 6 is fixed with an embedded ring 17, the lower end of the inner side of the top cover 6 is attached with the embedded ring 17, the upper end in the shell 3 is provided with a clamping groove 19, the inner side of the clamping groove 19 is embedded by the embedded ring 17, the upper end of the inner side of the shell 3 is fixedly provided with an embedded groove 20, the silicone ring 18 is placed inside the embedded groove 20.
Referring to fig. 10, the present invention provides a small animal plethysmograph box under high pressure, wherein the inner connecting pipe 5 of the conversion block 4 is connected with a three-way joint 51 through an external pipe, the other end of the three-way joint 51 is connected with a pressure difference converter, the other end of the three-way joint 51 is connected with a pressure stabilizer 52 through another set of external pipes, the pressure difference converter is connected with a recorder through an amplifier, the pressure stabilizer 52 can be connected with an external main control device through a connecting wire to set a pressure threshold, and a pressure display device is arranged on the pressure stabilizer 52 to monitor the pressure in real time.
Referring to fig. 4, the invention provides a plethysmograph box for small animals under high pressure by improving, wherein the anti-bite structure 13 includes a flexible adhesive sleeve 131, a fixing ring 132, a protective net 133 and a connecting ring 134, the outer side of the flexible adhesive sleeve 131 is bonded with the lower end of the inner side of the aerosol manifold 9, the fixing ring 132 is fixed at the bottom of the flexible adhesive sleeve 131, the outer side of the fixing ring 132 is connected with the connecting ring 134 through the protective net 133, the surface of the protective net 133 is smooth, and the protective net 133 is rigid, so that the protective effect is good and stable.
Referring to fig. 5, the invention provides a small animal plethysmograph box under high pressure through improvement, the auxiliary device 2 includes a side plate 21, a sliding mechanism 22, a first motor 23, a cover removing mechanism 24, a clamping adjusting mechanism 25, a second motor 26 and a hand wheel 27, the sliding mechanism 22 is installed at the rear end of the inner side of the side plate 21, the first motor 23 is installed at the back of the sliding mechanism 22, the cover removing mechanism 24 is installed at the top of the sliding mechanism 22, the clamping adjusting mechanism 25 is installed at the front end of the inner side of the side plate 21, the second motor 26 is installed at the rear end of the outer side of the clamping adjusting mechanism 25, and the hand wheel 27 is installed at the front end of the outer side of the clamping adjusting mechanism 25.
Referring to fig. 6, the invention provides a plethysmograph box for small animals under high pressure by improvement, the sliding mechanism 22 includes a box body 221, a sliding slot 222, a guiding slot 223, a threaded rod 224, a sliding part 225 and a guiding block 226, two sides of the box body 221 are fixed with the side plate 21, the middle part of the top end of the box body 221 is provided with the sliding slot 222, two ends of the top of the box body 221 are provided with the guiding slot 223, the middle part in the box body 221 is provided with the threaded rod 224, the outer side of the threaded rod 224 is provided with the sliding part 225, the top of the sliding part 225 penetrates through the top of the sliding slot 222 to be connected with the cover removing mechanism 24, the guiding block 226 is movably embedded in the guiding slot 223, the top of the guiding block 226 is connected with the cover removing mechanism 24, the middle part in the sliding part 225 is provided with internal threads, and the threaded rod 224 is in threaded connection with the middle part in the sliding part 225, which facilitates the sliding of the sliding part 225 to slide.
Referring to fig. 7, the invention provides a plethysmograph box for small animals under high pressure by improvement, the cover removing mechanism 24 includes a support 241, an air cylinder 242, a support 243, a spring plate 244 and a silica gel layer 245, the bottom of the support 241 is respectively connected with the top of the guide block 226 and the slide 225, the air cylinder 242 is installed at the upper end of the outer side of the support 241, the push-out rod inside the air cylinder 242 penetrates through the upper end of the support 241 and is connected with the support 243, the spring plate 244 is arranged inside the support 243, the silica gel layer 245 is adhered inside the spring plate 244, the guide rod is fixed at the lower end of the outer side of the support 243, and the outer side of the guide rod is movably embedded into the lower end of the support 241, so that the direction is stable and the sliding is smooth.
Referring to fig. 8, the invention provides a high-pressure small animal plethysmograph box, the clamping adjustment mechanism 25 includes a fixed box 251, an intermittent mechanism 252, a linkage shaft 253, a transmission box 254, a driving pulley 255, a synchronous belt 256, a driven pulley 257, a sliding rod 258, a screw 289 and a pressing plate 2510, the inner side of the fixed box 251 is connected with a side plate 21, the intermittent mechanism 252 is disposed inside the fixed box 251, the rear end of the outer side of the fixed box 251 is connected with a second motor 26, the front end of the inner side of the intermittent mechanism 252 penetrates through the inner side of the side plate 21 through the linkage shaft 253, the transmission box 254 is disposed inside the side plate 21, the driving pulley 255 is disposed at the inner rear end of the transmission box 254, the inner middle portion of the driving pulley 255 is connected with the linkage shaft 253, the outer side of the driving pulley 255 is synchronously rotated with the driven pulley 257 through the synchronous belt 256, the middle portion of the driven pulley 257 is connected with the sliding rod 28, the right side of the sliding rod 28 is disposed inside the side plate 21 and connected with the screw 289, the screw rod 289 is in threaded connection with the inside of the side plate 21, the outer side of the screw rod 289 is connected with the hand wheel 27, the inner side of the sliding rod 28 is in contact with the exhaust support 1 through a pressing plate 2510, convex teeth are arranged on the inner side of the driven belt wheel 257, slots are formed in the outer side of the sliding rod 258, the inner side of the driven belt wheel 257 is meshed with the outer side of the sliding rod 258, the sliding rod 258 can be stably driven to rotate, and the sliding rod 258 can move left and right.
Referring to fig. 9, the invention provides a plethysmograph box for small animals under high pressure by improvement, wherein the intermittent mechanism 252 includes a chassis 2521, a connecting shaft 2522, a rotating wheel 2523, a toggle column 2524, an intermittent wheel 2525 and a transmission shaft 2526, the inner side of the chassis 2521 is connected to the fixed box 251, the upper end of the outer side of the chassis 2521 is provided with the connecting shaft 2522, the outer side of the connecting shaft 2522 is connected to the output shaft of the second motor 26, the connecting shaft 2522 is connected to the inside of the rotating wheel 2523, the lower end of the outer side of the rotating wheel 2523 is provided with the toggle column 2524, the outer side of the toggle column 2524 is connected to the intermittent wheel 2525, the middle of the intermittent wheel 2525 is provided with the transmission shaft 2526, and the inner side of the transmission shaft 2526 is connected to the linkage shaft 253.
Example two
According to the small animal volume tracing box under high pressure, the supporting piece 243, the spring piece 244 and the silica gel layer 245 are arc-shaped through improvement, so that the top cover 6 can be clamped stably; a rubber layer is bonded on the inner side of the pressing plate 2510, and the thickness of the rubber layer is 1cm, so that stable friction force is provided when the shell 3 is clamped conveniently; four groups of strip-shaped grooves are formed in the intermittent wheel 2525, and the strip-shaped grooves are movably embedded by the toggle column 2524, so that the intermittent rotation of the intermittent wheel 2525 is conveniently realized.
The invention provides a small animal plethysmograph box under high pressure through improvement, and the working principle is as follows;
firstly, when the WBP body tracing box needs to be used, firstly, external detection equipment is sequentially connected with a test cavity pneumotach 7, a reference cavity pneumotach 8, an aerosol manifold 9, a water collecting pipe 14 and an exhaust port at the lower end of an exhaust support 1 through pipelines, then a conversion block 4 is connected with a differential pressure converter through a connecting pipe 5 on the conversion block through a pipeline, then the differential pressure converter is connected with an amplifier, the amplifier is connected with a recorder, and then a user puts the whole body into a high-pressure cabin for use;
secondly, when the top cover 6 is disassembled and assembled, a user can rotate the hand wheel 27, then the hand wheel 27 drives the screw rod 289 to rotate, and when the screw rod 289 rotates, the sliding rod 258 can be pushed into the inner side, so that the pressing plate 2510 contacts the exhaust support 1 to stably clamp the exhaust support;
thirdly, when the user starts the second motor 26 to work, the output shaft of the second motor 26 drives the connecting shaft 2522 to rotate, the connecting shaft 2522 drives the rotating wheel 2523 to rotate, the rotating wheel 2523 enables the shifting column 2524 to shift the intermittent wheel 2525, and the transmission shaft 2526 at the middle of the intermittent wheel 2525 enables the linkage shaft 253 to rotate when the intermittent wheel 2525 is shifted once for ninety degrees;
fourthly, the driving belt wheel 255 starts to rotate, the synchronous belt 256 on the outer side of the driving belt wheel 255 drives the driven belt wheel 257 to rotate, the middle part of the driven belt wheel 257 enables the sliding rod 258 to start to rotate, so that the pressing plate 2510 presses the exhaust support 1 and drives the exhaust support to perform angle adjustment, and the opening on the top of the shell 3 faces the cap removing mechanism 24 on the rear end;
fifthly, starting the first motor 23 to work, wherein the first motor 23 drives the threaded rod 224 to rotate, the sliding piece 225 on the outer side of the threaded rod 224 can slide on the threaded rod 224, then the sliding piece 225 drives the support 241 to slide on the sliding groove 222, and two ends of the bottom of the support 241 move towards the front end under the guidance of the guide block 226;
sixthly, the silica gel layers 245 at the two ends face the outer side of the top cover 6, the air cylinder 242 is started to work, the push rod on the inner side of the air cylinder 242 moves inwards, the supporting piece 243 clamps the top cover 6 through the spring piece 244, then the first motor 23 is started to rotate reversely, the support 241 is driven to reset, and the top cover is taken out;
seventhly, the mouse needs to be placed into the shell 3, the second motor 26 is started to continuously work, the exhaust support 1 rotates again, the opening in the shell 3 faces the front end, then the mouse is released at the front end and enters the shell 3, then the shell 3 is turned over again, the opening faces backwards, then the cover taking mechanism 24 is pushed in by the sliding mechanism 22, the top cover 6 is installed at the opening of the shell 3 to be sealed, the embedding ring 17 and the silica gel ring 18 on the inner side of the top cover 6 can be stably clamped into the clamping groove 19 and the embedding groove 20 in the shell 3 to achieve stable sealing, then the air cylinder 242 is started to return, and clamping of the top cover 6 is relieved;
eighthly, when a white mouse enters the shell 3, the bottom of the aerosol manifold 9 is provided with an anti-biting structure 13, a protective net 133 is arranged in the anti-biting structure 13, the protective net 133 is rigid, the damage to the lower end of the aerosol manifold 9 caused by the biting of the white mouse is avoided, and finally, the experiment can be started;
ninth, after pressure stabilizer 52 has set a pressure threshold, when pressure is added and reduced, three way connection 51 is opened, pressure stabilizer 52 intervenes, pressure stabilizer 52 realizes pressure release and stabilization according to the pressure threshold that sets up, makes it out of the cabin after, decompression speed slows down, and after breaking away from high-pressure environment, carries out the stabilization, improves pressure balance's efficiency.
The invention provides a small animal plethysmograph box under high pressure through improvement, an embedded ring 17 is arranged at the bottom of a top cover 6, a silica gel ring 18 is arranged on the inner side of the top cover and is matched with a clamping groove 19 at the upper end in a shell 3 and an embedded groove 20 at the upper end of the inner side of the top cover, the stability during connection is improved, the tightness is good after connection, and the integral air tightness is improved; the bottom of the aerosol manifold 9 is provided with an anti-biting structure 13, the upper end of the anti-biting structure 13 is connected with the aerosol manifold 9 through a flexible fitting sleeve 131, the bottom of the flexible fitting sleeve 131 is connected with a fixing ring 132, the bottom of the fixing ring 132 is provided with a protective net 133, and the protective net 133 is rigid, so that the rat bite can be effectively avoided; the outer side of the exhaust support 1 is connected with the auxiliary device 2, a clamping adjusting mechanism 25 is arranged in the auxiliary device 2, an independent hand wheel 27 is arranged in the clamping adjusting mechanism 25, and the pressing and clamping of the exhaust support 1 by the pressing plate 2510 on the inner side can be realized under the rotation of the hand wheel 27; an intermittent mechanism 2525 is also arranged in the clamping adjusting mechanism 25, the intermittent mechanism 2525 is driven by a motor, and the angle of the whole device can be adjusted in the clamping process through transmission of a pulley set under the driving of the motor; the rear end of the auxiliary device 2 is provided with a sliding mechanism 22, the top of the sliding mechanism 22 is connected with a cover taking mechanism 24, the cover taking mechanism 24 can be driven by the sliding mechanism 22 to move back and forth, when the cover taking mechanism 24 is matched with the shell 3 with the adjusted angle, the cover taking mechanism 24 is enabled to move, the air cylinder 242 is used for driving, the top cover 6 is clamped and taken out, after the cover taking mechanism is taken out, a white mouse can conveniently enter, the operation is convenient, manual operation is not needed, and the automation effect is good; be equipped with three way connection 51 on the connecting tube between connecting pipe 5 and outside differential pressure converter, and three way connection 51 other end connects pressure stabilizer 52, pressure stabilizer 52 can dock external control equipment, set up the pressure threshold value, through at the pressurization, steady voltage, and the in-process of decompression, the tee bend of controlling is opened, make pressure stabilizer 52 realize the pressure release according to the pressure threshold value, effectual control pressure risees and the speed that the pressure reduces, realize control and the stability to internal pressure lift process, avoid causing the destruction of internal mechanical structure because pressure, and break away from the stable quick realization pressure balance after the high pressure.
The basic principles and main features of the present invention and the advantages of the present invention have been shown and described, and the standard parts used in the present invention are all available on the market, the special-shaped parts can be customized according to the description and the accompanying drawings, the specific connection mode of each part adopts the conventional means of bolt and rivet, welding and the like mature in the prior art, the machinery, parts and equipment adopt the conventional type in the prior art, and the circuit connection adopts the conventional connection mode in the prior art, and the details are not described herein.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The utility model provides a small animal plethysmograph case under high pressure, includes exhaust support (1), the front end is equipped with the exhaust port in exhaust support (1), the upper end is equipped with shell (3) in exhaust support (1), the terminal surface upper end is equipped with conversion block (4) before shell (3), conversion block (4) front end embedding has connecting pipe (5), top cap (6) are installed at shell (3) top, both ends are equipped with test chamber pneumotacheometer (7) and reference chamber pneumotacheometer (8) respectively about top cap (6) top, shell (3) top middle part embedding has aerosol manifold (9), shell (3) inboard upper end is equipped with baffle (10), baffle (10) are separated shell (3) inside upper and lower both ends, and the upper end is reference chamber (11), and the lower extreme is test chamber (12), test chamber pneumotacheometer (7) and reference chamber pneumotacheometer (8) bottom are respectively through branch pipe and test chamber (12) and reference chamber pneumotacheometer (8) The test device is characterized in that the interior of a reference cavity (11) is communicated, a fine filter screen is arranged at the connecting position of the top of the branch pipe, the connecting position of the test cavity respiration speedometer (7) and the reference cavity respiration speedometer (8) is connected with the top of the branch pipe, the bottom of an aerosol manifold (9) penetrates through a partition plate (10) and is communicated with the test cavity (12), a supporting plate (15) is arranged at the inner lower end of the test cavity (12), the bottom of the supporting plate (15) is arranged at the inner upper end of an exhaust support (1) through a supporting leg (16), the left upper end of the test cavity (12) is communicated with a water production pipe (14), two groups of connecting pipes (5) are arranged in a conversion block (4), and the interiors of the two groups of connecting pipes (5) are respectively communicated with the interiors of the reference cavity (11) and the test cavity (12);
the method is characterized in that: the air exhaust support is characterized by further comprising an auxiliary device (2), an anti-biting structure (13), an embedding ring (17), a silica gel ring (18), a clamping groove (19) and an embedded groove (20), wherein the outer side of the air exhaust support (1) is connected with the auxiliary device (2), the bottom of the aerosol manifold (9) is connected with the anti-biting structure (13), the bottom of the top cover (6) is fixed with the embedding ring (17), the embedded ring (17) is attached to the lower end of the inner side of the top cover (6), the clamping groove (19) is formed in the upper end of the inner side of the shell (3), the clamping groove (19) is embedded into the clamping groove (17), the embedded groove (20) is fixedly formed in the upper end of the inner side of the shell (3), the silica gel ring (18) is arranged in the embedded groove (20), the inner connecting pipe (5) of the conversion block (4) is connected with the three-way joint (51) through an external pipeline, the other end of the three-way joint (51) is connected with the pressure difference converter, the other end interface of the three-way joint (51) is connected with a pressure stabilizer (52) through another group of external pipelines, the differential pressure converter is in butt joint with a recorder through an amplifier, the anti-biting structure (13) comprises a flexible attaching sleeve (131), a fixing ring (132), a protective net (133) and a connecting ring (134), the outer side of the flexible attaching sleeve (131) is bonded with the lower end of the inner side of the aerosol manifold (9), the bottom of the flexible attaching sleeve (131) is fixedly provided with the fixing ring (132), and the outer side of the fixing ring (132) is connected with the connecting ring (134) through the protective net (133).
2. The plethysmograph box of small animals at high pressure according to claim 1, characterised in that: auxiliary device (2) include curb plate (21), slide mechanism (22), first motor (23), get and cover mechanism (24), centre gripping adjustment mechanism (25), second motor (26) and hand wheel (27), slide mechanism (22) are installed to curb plate (21) inboard rear end, the slide mechanism (22) back is equipped with first motor (23), slide mechanism (22) top is equipped with gets and covers mechanism (24), the front end is equipped with centre gripping adjustment mechanism (25) in curb plate (21), second motor (26) are installed to centre gripping adjustment mechanism (25) outside rear end, centre gripping adjustment mechanism (25) outside front end is equipped with hand wheel (27).
3. The plethysmograph box of small animals at high pressure according to claim 2, characterised in that: slide mechanism (22) include box (221), spout (222), guide way (223), threaded rod (224), slider (225) and guide block (226), box (221) both sides are fixed with curb plate (21), spout (222) have been seted up at box (221) top middle part, guide way (223) have been seted up at box (221) top both ends, the middle part is equipped with threaded rod (224) in box (221), the threaded rod (224) outside is equipped with slider (225), slider (225) top is run through spout (222) top and is met with getting lid mechanism (24), guide block (226) have been embedded in the inside activity of guide way (223), guide block (226) top meets with getting lid mechanism (24).
4. The plethysmograph box of small animals at high pressure according to claim 3, characterised in that: get and cover mechanism (24) and include support (241), cylinder (242), support (243), spring leaf (244) and silica gel layer (245), support (241) bottom meets with guide block (226) and slider (225) top respectively, cylinder (242) are installed to support (241) outside upper end, cylinder (242) inboard ejector beam runs through support (241) upper end and meets with support (243), support (243) inboard is equipped with spring leaf (244), the inboard bonding of spring leaf (244) has silica gel layer (245).
5. The plethysmograph box of small animals at high pressure according to claim 1, characterised in that: the clamping adjusting mechanism (25) comprises a fixed box (251), an intermittent mechanism (252), a linkage shaft (253), a transmission box (254), a driving belt wheel (255), a synchronous belt (256), a driven belt wheel (257), a sliding rod (258), a screw rod (289) and a pressing plate (2510), wherein the inner side of the fixed box (251) is connected with a side plate (21), the intermittent mechanism (252) is arranged inside the fixed box (251), the rear end of the outer side of the fixed box (251) is connected with a second motor (26), the front end of the inner side of the intermittent mechanism (252) penetrates through the inner side of the side plate (21) through the linkage shaft (253), the transmission box (254) is arranged inside the side plate (21), the driving belt wheel (255) is arranged at the inner rear end of the transmission box (254), the middle part of the inner side of the driving belt wheel (255) is connected with the linkage shaft (253), the outer side of the driving belt wheel (255) and the driven belt wheel (257) synchronously rotate through the synchronous belt (256), the middle part in the driven belt wheel (257) is connected with a sliding rod (28), the right side of the sliding rod (28) is arranged in a side plate (21) and is connected with a screw rod (289), the screw rod (289) is in threaded connection with the inside of the side plate (21), the outer side of the screw rod (289) is connected with a hand wheel (27), and the inner side of the sliding rod (28) is in contact with an exhaust support (1) through a pressure plate (2510).
6. The plethysmograph box of small animals at high pressure according to claim 5, characterised in that: the intermittent mechanism (252) comprises a chassis (2521), a connecting shaft (2522), a rotating wheel (2523), a shifting column (2524), an intermittent wheel (2525) and a transmission shaft (2526), wherein the inner side of the chassis (2521) is connected with a fixed box (251), the upper end of the outer side of the chassis (2521) is provided with the connecting shaft (2522), the outer side of the connecting shaft (2522) is connected with an output shaft of a second motor (26), the connecting shaft (2522) is connected with the inside of the rotating wheel (2523), the lower end of the outer side of the rotating wheel (2523) is provided with the shifting column (2524), the outer side of the shifting column (2524) is connected with the intermittent wheel (2525), the middle part of the intermittent wheel (2525) is provided with the transmission shaft (2526), and the inner side of the transmission shaft (2526) is connected with a linkage shaft (253).
7. The plethysmograph box of small animals at high pressure according to claim 1, characterised in that: the surface of the protective net (133) is smooth, and the protective net (133) is rigid.
8. The plethysmograph box of small animals at high pressure according to claim 3, characterised in that: the inner middle part of the sliding part (225) is provided with internal threads, and the threaded rod (224) is in threaded connection with the inner middle part of the sliding part (225).
9. The plethysmograph box of small animals at high pressure according to claim 4, characterised in that: the lower end of the outer side of the supporting piece (243) is fixed with a guide rod, and the outer side of the guide rod is movably embedded into the lower end of the support (241).
10. The plethysmograph box of small animals at high pressure according to claim 5, characterised in that: the inner side of the driven belt wheel (257) is provided with convex teeth, the outer side of the sliding rod (258) is provided with a slot, and the inner side of the driven belt wheel (257) is meshed with the outer side of the sliding rod (258).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111540826.3A CN114224318B (en) | 2021-12-16 | 2021-12-16 | Small animal plethysmograph case under high pressure |
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| CN202111540826.3A CN114224318B (en) | 2021-12-16 | 2021-12-16 | Small animal plethysmograph case under high pressure |
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| CN114224318B CN114224318B (en) | 2024-03-29 |
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| US20040254489A1 (en) * | 2003-06-12 | 2004-12-16 | Joseph Lomask | Reduced-noise plethysmograph |
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| CN114224318B (en) | 2024-03-29 |
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