CN114224309B

CN114224309B - Physiological detection system and physiological detection device

Info

Publication number: CN114224309B
Application number: CN202111287198.2A
Authority: CN
Inventors: 林炯彣; 韩威如; 周洋铭; 蔡政男; 古人豪; 庄智元
Original assignee: Pixart Imaging Inc
Current assignee: Pixart Imaging Inc
Priority date: 2017-11-16
Filing date: 2018-10-26
Publication date: 2023-11-17
Anticipated expiration: 2038-10-26
Also published as: CN114224309A

Abstract

A physiological detection system includes an array sensor and a processing unit. The array sensor can be used for outputting an array change signal, and the processing unit is used for establishing three-dimensional energy distribution according to the array change signal and judging different microcirculation states.

Description

Physiological detection system and physiological detection device

The application relates to a split application of Chinese application patent application with the application number of 201811257149.2, the application date of 2018, 10 month and 26 days and the name of an array type physiological detection system and a physiological detection device.

Technical Field

The present application relates to a physiological detection system, and more particularly, to an array type physiological detection system capable of detecting physiological characteristics in at least three dimensions and an operation method thereof.

Background

At present, the portable electronic device (portable electronic device) and the wearable electronic device (wearable electronic device) are indispensable electronic products in life, and their functions are continuously evolving along with the change of the life style of people.

Meanwhile, physical health is a concern of people in life, and thus physiological detection functions are gradually applied to portable electronic devices and wearable electronic devices to meet the demands of users.

Disclosure of Invention

In view of the above, the present invention provides an array type physiological detection system and an operating method thereof, which can detect and record physiological characteristics of more than three dimensions of a user.

The invention provides an array type physiological detection system and an operation method thereof, which are used for respectively detecting physiological characteristics of different detected tissue areas through a plurality of sensing pixels so as to generate three-dimensional physiological characteristic distribution.

The invention also provides an array type physiological detection system and an operation method thereof, which can record the change of the three-dimensional physiological characteristic distribution of different detected tissue areas along with time and judge different microcirculation states according to the change.

The invention provides a physiological detection device, which comprises a light source module, a photosensitive array and a processing unit. The light source is for illuminating an area of skin with light of a first wavelength. The photosensitive array is used for detecting emergent light from the skin area and outputting a plurality of PPG signals. The processing unit is configured to convert the plurality of PPG signals into a three-dimensional energy distribution, identify a cyclic pattern in the three-dimensional energy distribution, and when the cyclic pattern is confirmed, represent that the three-dimensional energy distribution includes valid data.

The invention further provides a physiological detection system, which comprises a first array type PPG detector, a second array type PPG detector and a processing unit. The first array PPG detector is for generating a plurality of first PPG signals. The second array PPG detector is for generating a plurality of second PPG signals. The processing unit is configured to convert the plurality of first PPG signals and the plurality of second PPG signals into a first three-dimensional energy distribution and a second three-dimensional energy distribution, identify a ring pattern in the first three-dimensional energy distribution and the second three-dimensional energy distribution, and indicate that the physiological detection system is operating normally when the first three-dimensional energy distribution and the second three-dimensional energy distribution respectively include the ring pattern.

The invention also provides a physiological detection device which comprises a light source module, a photosensitive array and a processing unit. The light source module includes a plurality of light emitting diodes and is configured to illuminate a tissue region with light of a first wavelength emitted by different groups of light emitting diodes of the plurality of light emitting diodes. The photosensitive array is used for detecting emergent light from the tissue region and outputting a plurality of PPG signals. The processing unit is used for converting the PPG signals into three-dimensional energy distribution, identifying a ring-shaped pattern in the three-dimensional energy distribution obtained when the first group of light emitting diodes are lighted, and carrying out self-adjustment before prompting a user to carry out manual adjustment information when the ring-shaped pattern is not identified in the three-dimensional energy distribution.

In the array type physiological detection system and the operation method thereof in the embodiment of the invention, three-dimensional energy change of three-dimensional energy distribution representing physiological characteristic distribution along with time can be established to form a four-dimensional physiological detection system.

To make the above and other objects, features and advantages of the present invention more apparent, the following detailed description will be made in conjunction with the accompanying drawings. In the description of the present invention, the same members are denoted by the same symbols, and will be described herein.

Drawings

FIG. 1 is a flow chart of a physiological detection system for obtaining a shallow microcirculation vessel expansion and contraction change according to an illustrative embodiment of the present invention;

FIG. 2A is a schematic diagram of an image frame and its observation window acquired by the physiological detection system according to an illustrative embodiment of the present invention;

FIG. 2B is a schematic diagram illustrating brightness variation of a plurality of image frames acquired by the physiological detection system according to an embodiment of the present invention;

FIG. 2C is a graph showing the signal of the micro-circulation blood vessel swelling and shrinking according to the physiological detection system of the embodiment of the present invention;

FIG. 2D is a schematic diagram illustrating an energy distribution of a plurality of pixel regions at a current heartbeat frequency obtained by the physiological detection system according to the embodiment of the present invention;

FIG. 3A is a schematic diagram illustrating the variation of the variation detected by the physiological detection system according to an embodiment of the present invention;

FIG. 3B is a diagram illustrating the mean value variation detected by the physiological detection system according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of a physiological detection system according to an illustrative embodiment of the present invention;

FIG. 5 is a flowchart illustrating a method of operating a physiological detection system according to an embodiment of the present invention.

FIGS. 6A and 6B are schematic diagrams illustrating three-dimensional energy distribution of 525 nm light detected by physiological detection according to an embodiment of the present invention;

FIGS. 7A and 7B are schematic diagrams of three-dimensional energy distribution of 880 nm light detected by physiological detection according to an illustrative embodiment of the present invention;

FIG. 8 is a schematic diagram illustrating a physiological testing device according to another embodiment of the present invention; a kind of electronic device with high-pressure air-conditioning system

FIG. 9 is a block diagram illustrating a physiological detection system according to yet another embodiment of the present invention.

Detailed Description

The following description contains specific embodiments of the present invention in order to provide an understanding of how the present invention may be applied to actual situations. It should be noted that in the following drawings, parts irrelevant to the description of the present invention have been omitted, and in order to highlight the relationship between components, the proportion between components in the drawings is not necessarily the same as the proportion between actual components.

Referring to fig. 1, a flowchart of an array type physiological detection system for obtaining a shallow microcirculation vessel expansion and contraction change according to an embodiment of the invention is shown. The array type physiological detection system is used for detecting three-dimensional energy distribution of the swelling and shrinking changes of the shallow microcirculation blood vessels of the body tissue through the skin surface so as to help a user monitor self health. In addition, the array type physiological detection system of the embodiment of the invention can be applied to a portable electronic device or a wearable electronic device to realize a portable physiological monitoring device and is suitable for long-term self-monitoring. For example, the three-dimensional energy variation of the three-dimensional energy distribution over time, i.e. the variation of the microcirculation information over time, may be monitored over time. Therefore, the obtained monitoring data can be matched with the detection result of short-term health examination carried out by a medical institution so as to obtain high-reliability physiological state information.

First, the array type physiological detection system reads a plurality of shallow microcirculation blood vessel expansion and contraction change signals output by a plurality of pixel areas, as shown in step 101, for example, an optical volume change description waveform (PPG) signal. In order to acquire shallow microcirculation vessel swelling and shrinking change signals of a plurality of pixels, a physiological detection system needs to acquire vessel swelling and shrinking change signals of a dermis layer (dermis) to represent microcirculation data. For example, an optical detection method may be used, such that light with a specific wavelength can penetrate the epidermis layer (epidermis) but not the dermis layer, and then a photosensitive array is used to detect the micro-circulation vasomotor change signal in the skin region; the photosensitive array comprises a plurality of photosensitive pixels, each of which can generate a micro-circulation blood vessel expansion and contraction change signal, and various statistical values of the micro-circulation blood vessel expansion and contraction change signal can be provided for subsequent application.

For example, light of wavelength 525 nanometers (nm) may be used, with skin penetration depths below 1 millimeter (mm). Light of different wavelengths may be used at different body parts to ascertain the state of the microcirculation vascular changes in the dermis. Since the depth of the dermis layer is approximately 1-3 mm, the wavelength of the light is preferably chosen to be impenetrable to a depth of 3 mm, e.g. 300-940 nm.

Then, the physiological detection system establishes three-dimensional energy distribution according to the differential microcirculation blood vessel expansion and contraction change signal, as shown in step 102; wherein the three-dimensional energy distribution refers to a spectral energy distribution. In this step, since the energy of the micro-circulation blood vessel expansion and contraction change signal detected by each pixel contains various different frequencies, one of the frequencies can be selected for data analysis. In one embodiment, the current heartbeat can be estimated by using the differential microcirculation blood vessel expansion and contraction variation signals, and based on the current heartbeat, the amplitude variation value of the amplitude signal of each pixel under the heartbeat frequency is collected to represent the expansion and contraction variation of the shallow microcirculation blood vessel.

Since the collapsible variation of the shallow microcirculation vessel follows the heart beat, the amplitude variation of the pixels will be more pronounced at the heart beat frequency or its multiple frequency than at other frequencies for subsequent analysis.

Next, a physiological state is determined based on the characteristic parameters of the energy distribution, as shown in step 103. In this step, the physiological state can be estimated from various characteristics of the energy distribution, such as amplitude variation, average value, heart beat frequency, and the like. How to determine the physiological characteristics based on the characteristic parameters will be described later.

Next, a physiological status alert may be provided to the user, as shown in step 104, so that the user may adjust the content of the work and rest and activity accordingly.

Fig. 2A-2D are schematic diagrams of an array type physiological detection system for obtaining a shallow microcirculation vascular swelling and shrinking change according to an illustrative embodiment of the invention. Taking an optical physiological detection system as an example, fig. 2A is a schematic diagram of an acquired image frame and its observation Window (WOI); wherein, the size and the position of the WOI of the observation window can be adjusted. FIG. 2B is a schematic illustration of a plurality of image frames (e.g., shown within 6 seconds) or a change in brightness of an observation window of the plurality of image frames; wherein the brightness change reflects the swelling and shrinking change of the microcirculation blood vessel. Fig. 2C is a graph of a shallow micro-circulation vessel collapsible change signal, which is obtained by converting the brightness change (i.e. the shallow micro-circulation vessel collapsible change signal) of fig. 2B into frequency, and shows the current heartbeat frequency. FIG. 2D is a schematic diagram showing an array variation of energy values obtained from a plurality of pixel regions at the current heart beat frequency, i.e. an amplitude distribution; wherein the columnar height represents the spectral energy relative to the current heart beat frequency. It can be seen from fig. 2D that the detection result (i.e., the magnitude) obtained in each pixel region is changed, and the change state can represent the change of the physiological characteristic (such as the distribution and operation of the microvessels in the dermis layer, etc.), which is described in detail below. It should be noted that the amplitude of each pixel in fig. 2D is the energy value of one pixel or the average energy value of a plurality of pixels.

The present invention describes that different microcirculation states can be used to estimate the motion state. For example, the different microcirculation states can be divided into four states, namely a pre-exercise state I, a warming-up state II, an in-exercise state III and a post-exercise cooling state IV, and the following are exemplified:

referring to fig. 3A and 3B, fig. 3A is a schematic diagram illustrating a variation detected by the physiological detection system according to an embodiment of the invention; FIG. 3B is a diagram illustrating the mean value variation detected by the physiological detection system according to an embodiment of the present invention.

When the user is in the pre-exercise state I, the amplitude variation (a) of the amplitude signal is not high, but the average value (B) of the amplitude signal is high.

When the user is in the warming-up state II, the amplitude variation (a) of the amplitude signal gradually increases, but the average value (B) of the amplitude signal starts to decrease. When the average value (B) of the amplitude signal is lower than the warm-up average threshold (e.g., THa 1), it indicates that warm-up is completed; alternatively, when the average value (B) of the amplitude signal is below the warm-up threshold (e.g., THa 1) and the amplitude variation (a) of the amplitude signal is above the warm-up variation threshold (e.g., THv 1), this indicates that the warm-up is completed.

When the user is in state III in motion, the amplitude variation (a) of the amplitude signal is maintained at a high value, but the average value (B) is reduced to a relatively low level. When the average value (B) of the amplitude signal is lower than the moving average threshold (e.g. THa 2), it is represented in motion; alternatively, when the average value (B) of the amplitude signal is below a motion threshold (e.g., THa 2) and the amplitude variation (a) of the amplitude signal is above a motion variation threshold (e.g., THv 2), it is representative of being in motion.

When the user is in the cooling-after-exercise state IV, the amplitude variation (a) of the amplitude signal gradually decreases, the average value (B) of the amplitude signal starts to increase, and when the average value (B) returns to exceed the cooling average threshold value (e.g., THa 3), it indicates that the cooling is completed; alternatively, when the average value (B) returns to exceed the cooling average threshold (e.g., THa 3) and the amplitude variation (a) of the amplitude signal returns to below the cooling average threshold (e.g., THv 3), it indicates that the cooling is complete.

It should be noted that although four micro-circulation states, three variation thresholds and three average thresholds are shown in fig. 3A-3B, they are merely for illustration and not for limiting the description of the present invention, and the number and values of the micro-circulation states, the variation thresholds and the average thresholds are determined according to different applications.

Referring to fig. 4, a schematic diagram of an array type physiological detection system 400 according to an embodiment of the invention is shown. The array type physiological detection system 400 is used for detecting the change of skin microcirculation, and comprises a light source 41, a photosensitive array 43 and a processing unit 45.

The light source 41 may be a coherent light source, a non-coherent light source, or a partially coherent light source, such as a light emitting diode, a laser diode, or the like. The light source 41 is used to provide light L to illuminate an area of skin and the light penetrates into the dermis layer of the area of skin. It should be noted that the array type physiological detection system 400 is only used for detecting the micro-circulation vascular change state in the dermis layer, but not other tissue states in the subcutaneous tissue under the dermis layer, so the proper wavelength of light is selected to achieve the effect. Thus, the wavelength of the light source 41 is selected not to penetrate into the subcutaneous tissue of the dermis of the skin region, for example the light source wavelength is selected to be between 300-940 nm.

In other embodiments, the light source module may have a plurality of light sources, such as light sources with different wavelengths of 525 nm, 880 nm, and 606 nm, to obtain different results of reflected light and scattered light from the human body. For example, when a 525 nm short wavelength light source is used, the result of the three-dimensional energy distribution may be a ring pattern (arc-like pattern) in response to physical pressure applied to the human body. The ring-like pattern may be used to assess whether the system has been properly worn by the user.

The use of a short wavelength light source in the 300 to 940 nm may cause more significant absorption changes in the human body, which is presumed to be one reason for the ring-like pattern as in fig. 6A-6B. The long wavelength light source in 300-940 nm can be used for presenting a strong detection result of three-dimensional energy distribution in a high-voltage state, so that the system can be switched to different light sources under different conditions (tightly worn or loosely worn) to obtain good three-dimensional energy distribution. For example, fig. 7A and 7B are schematic diagrams of three-dimensional energy distribution when irradiated with long wavelength light, in which a clear annular pattern is not observed.

The photosensitive array 43 is preferably an active image sensor array, such as a CMOS image sensor, so that the size and position of the observation window WOI (as shown in fig. 2A) can be selected in real time according to the sampling result, for example, the observation window WOI is determined according to the image quality or brightness distribution, etc., and the pixel data outside the observation window WOI in the photosensitive array 43 may not be outputted by the photosensitive array 43. The photosensitive array 43 includes a plurality of photosensitive pixels, each of which is used to continuously detect the outgoing light passing through the dermis layer of the skin region to output a plurality of brightness signals as PPG signals (i.e., shallow microcirculation blood vessel swelling change signals), as shown in fig. 2B. In some embodiments, the plurality of luminance signals are digital signals, i.e., the photosensitive array 43 may include an analog-to-digital converter (ADC) for analog-to-digital conversion.

The processing unit 45 is configured to convert the luminance variation signals (i.e. PPG signals) corresponding to the photosensitive pixels into frequency domain data (as shown in fig. 2C), so as to form a three-dimensional energy distribution of the micro-circulation blood vessel swelling variation (as shown in fig. 2D). The processing unit 45 also calculates the variation and average value of the plurality of frequency domain data to determine different microcirculation states according to the variation of the variation (e.g. fig. 3A) and the variation of the average value (e.g. fig. 3B). The processing unit 45 may be, for example, a Digital Signal Processor (DSP), a Central Processing Unit (CPU), a Microcontroller (MCU), or the like, which may be used to calculate the data output by the sensing array, without particular limitation.

The processing unit 45 may perform the above operations using software, hardware, firmware, or a combination thereof. For example, the processing unit 45 may include a frequency domain conversion module 451, a heartbeat calculation module 452, a change calculation module 453, an average calculation module 454, a comparison unit 455, and a storage unit 456. It will be appreciated that fig. 4 illustrates different operation functions with different components, however, since the components are located in the processing unit 45, the operations performed by the components are those performed by the processing unit 45. In addition, the processing unit 45 may further include other operation functions, such as filtering, amplifying, etc., and the description of other functions not directly related to the present invention is omitted.

For example, each light sensitive pixel of the light sensitive array 43 outputs a time varying luminance signal as a PPG signal (as shown in fig. 2B), and the processing unit 45 is configured to calculate a heartbeat frequency from a plurality of the PPG signals.

In one embodiment, the frequency domain conversion module 451 converts the PPG signal (shown in fig. 2B) corresponding to each pixel to the frequency domain to generate frequency domain data (shown in fig. 2C), and the heartbeat calculation module 452 calculates an estimated heartbeat frequency according to the frequency domain data corresponding to each pixel, and takes the estimated heartbeat frequency with the highest statistic among the estimated heartbeat frequencies corresponding to the pixels as the heartbeat frequency. That is, an estimated heartbeat frequency can be calculated for each of the plurality of photosensitive pixels, and when the number of photosensitive pixels for which an estimated heartbeat frequency is calculated is the largest, the estimated heartbeat frequency is taken as the heartbeat frequency. Thus, errors caused by noise interference can be reduced to increase the calculation accuracy.

In another embodiment, the processing unit 45 calculates the sum of the brightness signals of all or part of the plurality of photosensitive pixels in each image frame (or within the observation window) output by the photosensitive array 43, and calculates the heartbeat frequency from the sum of the brightness signals of the plurality of image frames. That is, in this embodiment, the processing unit 45 obtains the brightness sum for each image frame, and the brightness sum change can be obtained for a plurality of image frames as the PPG signal, as shown in fig. 2B. In this embodiment, the heartbeat calculation module 452 may directly calculate the heartbeat frequency in the time domain (time domain), for example, calculate the inverse of the time interval THR in fig. 2B; alternatively, the frequency domain conversion module 451 converts the brightness and the variation to the frequency domain to generate frequency domain data, as shown in fig. 2C, and then the heartbeat calculation module 452 calculates the heartbeat frequency, as the frequency spectrum energy value with the highest frequency spectrum energy value in fig. 2C, according to the frequency domain data. In other words, in the present description, fig. 2B may represent a change in brightness output by a single photosensitive pixel or brightness and change output by a plurality of image frames; fig. 2C may represent frequency domain data of luminance variation output by a single photosensitive pixel or frequency domain data of luminance and variation output by a plurality of image frames, depending on the application. In the present description, the time-frequency conversion may be performed by a suitable frequency domain conversion algorithm, such as fast fourier, without specific limitation.

After the heartbeat frequency is determined, the change calculation module 453 can generate a spectral energy value at the heartbeat frequency with respect to each of the plurality of light sensing pixels to form a three-dimensional energy distribution or energy set, as shown in fig. 2D. The change calculation module 453 calculates the energy change amount of the three-dimensional energy distribution or the energy set as an amplitude change value, for example, calculates the sum of differences between adjacent pixel energies, the sum of differences between each pixel energy and average energy, the change number (variance) of the energy set, and the like, as long as the change between the energy components (components) representing the three-dimensional energy distribution or the energy set can be calculated, and is not particularly limited. In this embodiment, the variation is a spectrum energy variation of the heartbeat frequency.

After the heartbeat frequency is determined, the average calculation module 454 may generate a spectral energy value at the heartbeat frequency with respect to each of the plurality of light sensing pixels to form a three-dimensional energy distribution or energy set, as shown in fig. 2D. The average calculation module 454 calculates an average of the three-dimensional energy distribution or energy set as an amplitude average. In this embodiment, the average value is a spectrum energy average value of the heartbeat frequency.

The three-dimensional energy distribution in FIG. 2D can be used to calculate and generate representative locations for subsequent review. For example, a distribution value exceeding a threshold value may be used to calculate a centroid position, a center of gravity position, or a center position of a distribution value used. The representative position is changed according to a physiological state of the user, wherein the physiological state is related to limb movements or physical and psychological changes of the user.

It should be noted that, although the three-dimensional energy distribution or energy set generated by the change calculation module 453 and the average calculation module 454 is described in the above embodiment, the present invention is not limited thereto, and the three-dimensional energy distribution or energy set may be calculated by other modules included in the processing unit 45, for example, the frequency domain conversion module 451, the heartbeat calculation module 452, and the like, and is not limited thereto.

In some embodiments, the processing unit 45 may also determine the different microcirculation states in combination with the heartbeat frequency in addition to the variation of the variation amount and the variation of the average value. That is, in the description of the present invention, the processing unit 45 may determine different microcirculation states (microcirculation state) according to different combinations of the variation, the average value and the variation of the heartbeat frequency, for example, the pre-exercise state, the after-exercise state, the post-exercise cooling state, etc., but not limited thereto.

The comparison unit 455 may be configured to compare the variation with at least one variation threshold (e.g., THv1-THv3 of fig. 3A) to determine different microcirculation states. The comparison unit 455 may be configured to compare the average value with at least one average threshold (e.g., THa1-THa3 of fig. 3B) to determine different microcirculation states. The comparison unit 455 may be configured to compare the heart beat frequency with at least one heart beat threshold to determine different microcirculation states. The threshold value may be stored in the storage unit 456 in advance; the storage unit 456 may be, for example, a known memory, and is not limited thereto.

Referring to fig. 5, a method for detecting a change in skin microcirculation by using a plurality of photosensitive pixels is shown. The operation method comprises the following steps: illuminating a skin region with light provided by a light source and penetrating into a dermis layer of the skin region (step S51); continuously detecting the outgoing light passing through the dermis layer of the skin region with each photosensitive pixel to output brightness variation signals, respectively (step S52); converting the brightness variation signal with respect to each photosensitive pixel into frequency domain data (step S53); calculating variation and/or average values of the plurality of frequency domain data relative to the plurality of photosensitive pixels (step S54); and judging the microcirculation state according to the variation and/or the variation of the average value (step S55).

Referring to FIGS. 2A-2D, 3A-3B and 4-5, embodiments of the present operation method are described below.

Step S51: the light source 41 provides light L that irradiates the skin area and penetrates into the dermis layer of the skin area. As described above, the wavelength of the light L is selected not to penetrate to the subcutaneous tissue, so that the plurality of photosensitive pixels detect only the data of the microcirculation blood vessel and not the data of the subcutaneous tissue.

Step S52: each photosensitive pixel of the photosensitive array 43 continuously detects the emitted light passing through the dermis layer of the skin region to output brightness variation signals, such as PPG signals of fig. 2B, respectively. Therefore, the number of PPG signals output by the photosensitive array 43 is the same as the number of effective pixels.

Step S53: the processing unit 45 converts the brightness variation signal corresponding to each photosensitive pixel into frequency domain data, as shown in fig. 2C. Thus, the number of generated frequency domain data is also the same as the number of effective pixels.

Step S54: the processing unit 45 then calculates the variance and/or average of the plurality of frequency domain data relative to the plurality of photosensitive pixels. As mentioned above, since the plurality of frequency domain data are located at the heart beat frequency or a multiple thereof, the characteristics are more remarkable. Therefore, before calculating the variation and/or the average value, the processing unit 45 calculates the heartbeat frequency according to the brightness variation signals, which may be calculated directly in the time domain or calculated in a different manner in the frequency domain, as described above, and generates a three-dimensional energy distribution or energy set at the heartbeat frequency, as shown in fig. 2D. Then, the processing unit 45 may calculate a spectrum energy average value of the heartbeat frequency and/or a spectrum energy variation value of the heartbeat frequency according to the three-dimensional energy distribution or energy set; the calculation of the variation is described above, and thus will not be described herein.

Step S55: the processing unit 45 may determine a microcirculation state according to the variation amount and/or the variation of the average value with time; the determination may be, for example, comparing the variation to at least one variation threshold and/or comparing the average to at least one average threshold, such as those shown in fig. 3A-3B.

As mentioned above, in some embodiments, the processing unit 45 may also determine the microcirculation status along with the change of the heartbeat frequency with time.

Finally, the processing unit 45 may prompt the user of the determined microcirculation status in different manners, such as by image, sound, etc., without specific limitation.

In summary, the present invention is not based on the percentage of the maximum heart rate and the subjective judgment of the user to judge the movement state, but based on the superficial microcirculation vascular changes of the skin related to the blood flow distribution; wherein the data of the skin shallow microcirculation blood vessel change is represented by a plurality of brightness signals output by continuously detecting emergent light passing through the dermis layer by a plurality of photosensitive pixels of a photosensitive array, and the change of the brightness signals can be called light volume change description waveform (PPG) signals.

As described in the previous example, the processing unit 45 determines to enter the warm-up completed state when the average value decreases to be less than a warm-up average threshold (e.g., THa 1) and/or the variation increases to be greater than a warm-up variation threshold (e.g., THv 1). When the average value in turn decreases to less than a moving average threshold (e.g., THa 2) and/or the amount of change in turn increases to greater than a moving change threshold (e.g., THv 2), the processing unit 45 determines to enter the moving state. The processing unit 45 determines to enter the post-motion cooling state when the average value increases from below the moving average threshold to greater than a cooling average threshold (e.g., THa 3) and/or decreases from above the motion change threshold to less than a cooling change threshold (e.g., THv 3). Furthermore, the comparison of different states with thresholds depends on the different applications.

In another embodiment, the physiological testing apparatus, such as 400 of FIG. 4, is also used to confirm that the physiological testing apparatus is in good contact with the skin surface, so that the physiological testing apparatus can function properly. It is known that relative movement between the skin surface and the physiological detection device can reduce the image quality. Therefore, it is important to confirm the contact state.

For example, referring to fig. 4, the physiological detection device 400 of the present embodiment includes a light source module 41, a photosensitive array 43 and a processing unit 45. In addition, the physiological detection device 400 of the present embodiment further includes a display 47 (as shown in fig. 8) for displaying the detection result of the physiological detection device, for example, displaying warning information, indication information, and the like.

In this embodiment, the light source module 41 is used to emit light with different wavelengths to a tissue region under the skin to detect different depths of the tissue region. As previously mentioned, short wavelengths may be used to confirm whether good wear has been established. For example, the light source module 41 emits light with a first wavelength, such as between 500 nm and 550 nm, to the tissue region to be measured.

The photosensitive array 43 is used to detect the outgoing light of the tissue region and output a plurality of PPG signals, each as shown in fig. 2B. As described above, the present invention is configured such that one pixel outputs one PPG signal (as shown in fig. 2B), or a plurality of pixels outputs one average PPG signal (as shown in fig. 2B), for example, calculated by a hardware circuit.

The processing unit 45 is configured to convert the PPG signals into a three-dimensional energy distribution, for example, as shown in fig. 2D, identify a ring-shaped pattern in the three-dimensional energy distribution, and when the ring-shaped pattern is confirmed, for example, as shown in fig. 6A and 6B, control the display 47 to display information that the physiological detection device 400 is ready (i.e., well-worn). The manner in which the three-dimensional energy distribution is produced has been described above.

In one non-limiting embodiment, the ring-shaped pattern comprises at least one ring formed by energy values in the three-dimensional energy distribution that are greater than an energy threshold, such as the lighter colored peaks of fig. 6A and 6B. More than one ring can be seen from fig. 6A and 6B. The processing unit 45 may also derive the loop in other ways, for example by calculating the difference of the energy values of neighboring pixels and finding the regional extremum in the three-dimensional energy distribution as the loop.

However, if there is no looped pattern in the three-dimensional energy distribution, this indicates that the physiological detection device 400 is not worn or sufficiently tight to perform physiological detection. Therefore, when the annular pattern cannot be confirmed, the processing unit 45 is further configured to control the display 47 to display information for changing the wearing position or the tightness state of the physiological detection device 400. The physiological detection device 400 is configured to provide alert information to the user until the annular pattern is confirmed. After the annular pattern is confirmed, the three-dimensional energy distribution detected by the physiological detection device 400 is considered to contain valid data.

As previously described, the physiological testing apparatus 400 of the present invention is capable of testing shallow microcirculation at different tissue depths. For example, the processing unit 45 is further configured to control the light source module 41 to emit light of a second wavelength longer than the first wavelength, so that the photosensitive array 43 detects the emitted light from different tissue depths after the annular pattern is confirmed. In one non-limiting embodiment, the second wavelength is between 850 nm and 900 nm or between 590 nm and 620 nm, without particular limitation. By varying the wavelength of light and analyzing the three-dimensional energy distribution relative to different wavelengths of light, more detailed information of the examined tissue region can be obtained. In a non-limiting embodiment, the processing unit 45 is configured to control the display 47 to display information that changes the wavelength of light to obtain a suitable three-dimensional energy distribution.

For example, fig. 7A and 7B are schematic diagrams of three-dimensional energy distribution of 880 nm emitted light from the light source module 41, where a 480×480 pixel photosensitive array is used, and each pixel size is 5 microns×5 microns. It can be seen that fig. 7A and 7B do not have a ring pattern. This is because when using light of longer wavelengths, the emitted light passes through more tissue (including shallow tissue and deeper tissue), so the three-dimensional energy distribution reflects more complex data. The detected three-dimensional energy distribution associated with longer wavelength light requires more complex processing. Thus, in one non-limiting embodiment, the processing unit 45 is not used to identify the ring-shaped pattern in the three-dimensional energy distribution associated with the light of the second wavelength for simplicity of processing. That is, in the present description, the processing unit 45 is configured to determine whether the physiological detection device 400 is properly worn based on the shorter wavelength light, such as the first wavelength, but does not use the longer wavelength light, such as the second wavelength, to determine the wearing condition.

Furthermore, the processing unit 45 is also arranged to control the display 47 to display information indicative of the direction of the movement of the physiological detection device 400 for obtaining meaningful data. Fig. 7A and 7B are three-dimensional energy distributions detected by the photosensitive array 43 using the same wavelength light and at different time points. The three-dimensional energy distribution repeatedly changes between fig. 7A and 7B over time. It can be seen that there is always a higher energy value over time in the lower Y-axis portion (approximately y=0 to 10), which can be seen as the detected data exceeding the detectable range of the system. Thus, the processing unit 45 informs the user via the display 47 to move the physiological detection device 400 towards the positive Y-axis direction (e.g., y=40) to avoid detecting areas of consistently high energy values.

In other embodiments, the processing unit 45 calculates the centroid position, or the center point of the three-dimensional energy distribution. If the determined position is not located at the center of the three-dimensional energy distribution, the processing unit 45 controls the display 47 to direct the user to move the physiological detection device 400 so that the position is near the center of the three-dimensional energy distribution. That is, the processing unit 45 is configured to control the display 47 to display directions to move the physiological detection device 400 to a predetermined area, for example, an area having more blood vessels.

In the above-described embodiments, when the physiological monitor device 400 is not properly worn, the physiological monitor device 400 notifies the user to change positions or to wear with different tightness.

In other embodiments, the physiological monitor 400 performs a self-adjustment, and if the self-adjustment is not satisfactory, such as detecting a ring-shaped pattern, the user is notified of the adjustment position or tightness as described above. Referring to fig. 8, a schematic diagram of a physiological detection device 400 according to another embodiment of the invention also includes a light source module, a photosensitive array 43, and a processing unit 45. In this embodiment, the physiological monitor device 400 also includes a display 47.

The light source module of the present embodiment includes a plurality of light emitting diodes, for example, fig. 8 shows light emitting diodes 411 to 416. The light source module emits emitted light of a first wavelength toward the tissue region with different groups of light emitting diodes of the plurality of light emitting diodes, wherein the first wavelength is between 500 nanometers and 550 nanometers. For example, the first group of light emitting diodes comprises light emitting diodes 411 to 413. It should be noted that the number of leds and the size of the photosensitive array are not limited to those shown in fig. 8.

The photosensitive array 43 is used to detect the outgoing light from the tissue region and output a plurality of PPG signals, each as shown in fig. 2B, for example. It should be noted that the configuration of the photosensitive array 43 and the plurality of leds 411 to 416 is not limited to that shown in fig. 8, as long as the photosensitive array 43 can detect the emitted light from different directions when the dot amounts of the leds are different.

The processing unit 45 is configured to convert the plurality of PPG signals into a three-dimensional energy distribution, identify a ring pattern in the three-dimensional energy distribution obtained when the first group of leds is lit, and control the second group of leds, e.g., leds 414 to 416, to emit light when the ring pattern cannot be confirmed in the three-dimensional energy distribution. The ring-shaped pattern is described above, and thus will not be described again here.

This embodiment differs from the previous embodiment in that the processing unit 45 changes the further group of leds to illuminate the tissue region when the ring-like pattern cannot be confirmed in the three-dimensional energy distribution associated with the first group of leds, but the first wavelength is also used. In addition to varying the light emitting diode illumination of different locations, the processing unit 45 also selects to vary the window of interest (e.g., WOI of fig. 2A) in the image frame acquired by the photosensitive array 43 to acquire the appropriate three-dimensional energy distribution. If the ring pattern is detected by self-adjustment, e.g. by varying the number of leds or changing the WOI, the processor 45 does not control the display 47 to display information for manual adjustment.

As previously described, if the line is self-adjusting, the physiological detection device 400 can be used to detect shallow microcirculation at different tissue depths. That is, the processor 45 is also configured to control the light source module to emit light at a second wavelength longer than the first wavelength when the presence of the annular pattern is confirmed in the three-dimensional energy distribution associated with the first group of light emitting diodes. As previously mentioned, the second wavelength is selected to be between 850 nanometers and 900 nanometers, or between 590 nanometers and 620 nanometers, but is not limited thereto.

In another embodiment, the physiological detection system comprises two physiological detection devices, such as so-called array PPG detectors, to monitor shallow microcirculation at different parts of the human body. For example, referring to FIG. 9, a block diagram of a physiological detection system 500 illustrating yet another embodiment of the present invention is shown.

The physiological detection system 500 comprises a first array PPG detector 501, a second array PPG detector 503, a processing unit 505 and a display 507. It should be noted that although the processing unit 505 is shown in fig. 9 to be disposed outside the first array PPG detector 501 and the second array PPG detector 503, the present invention is not limited thereto. In one non-limiting embodiment, the processing unit 505 is configured inside the first array PPG detector 501 or the second array PPG detector 503.

The first and second arrayed PPG detectors 501 and 503 include a photosensitive array 43 similar to that of fig. 4. In this embodiment, the first array PPG detector 501 is used to generate a plurality of first PPG signals, and the second array PPG detector 503 is used to generate a plurality of second PPG signals. The manner in which the photosensitive array generates multiple PPG signals (as shown in fig. 2B) has been described above.

For example, the first array PPG detector 501 includes a first light source module and a first photosensitive array. The first light source module is used for emitting light with a first wavelength to illuminate a first tissue region. The first photosensitive array is for detecting outgoing light from the first tissue region and generating a plurality of first PPG signals. The second array PPG detector 503 includes a second light source module and a second photosensitive array. The second light source module is configured to emit light of a second wavelength to illuminate a second tissue region. The second light sensitive array is for detecting the outgoing light from the second tissue region and generating a plurality of second PPG signals. For example, the first wavelength is between 500 nanometers and 550 nanometers.

The display 507 is used to display the detection result of the physiological detection system.

The processing unit 505 converts the plurality of first PPG signals and the plurality of second PPG signals into a first three-dimensional energy distribution and a second three-dimensional energy distribution, respectively, using a method similar to the method described above. In this embodiment, the first tissue region is located, for example, in the hand of the user and the second tissue region is located, for example, in the foot of the user, and there is no particular limitation as long as the two array PPG detectors are located on different skin surfaces to be detected. For example, the processing unit 505 compares the first three-dimensional energy distribution with the second three-dimensional energy distribution to determine whether the micro-cycle of the hand or the foot is poor, such as caused by sitting in the same sitting position for a long time. Similarly, before making the comparison, the processing unit 505 confirms whether the first and second array PPG detectors 501 and 503 are well-worn. That is, the processing unit 505 recognizes the loop pattern in the first three-dimensional energy distribution and the second three-dimensional energy distribution. When both the first three-dimensional energy distribution and the second three-dimensional energy distribution each include a circular pattern, it is indicated that the physiological detection system 500 is functioning properly.

After the loop pattern is confirmed in both the first three-dimensional energy distribution and the second three-dimensional energy distribution, the physiological detection system 500 can also continuously monitor the changes of the first three-dimensional energy distribution and the second three-dimensional energy distribution over time.

In one embodiment, the processing unit 505 calculates a first average of the first three-dimensional energy distribution and calculates a second average of the second three-dimensional energy distribution, respectively. The processing unit 505 also calculates a ratio or difference of the first average value to the second average value, and monitors a change in the ratio or difference. When the ratio or difference changes beyond a change threshold, indicating that the microcirculation status of the two body parts under monitoring is different, the processor 505 is configured to control the display 507 to display an alert signal to inform the user of the active body.

In another embodiment, the processing unit 505 compares the first three-dimensional energy distribution and the second three-dimensional energy distribution with an energy threshold, and calculates a first region in the first three-dimensional energy distribution having energy greater than the energy threshold and a second region in the second three-dimensional energy distribution having energy greater than the energy threshold. The processing unit 505 monitors the change in the ratio or difference of the first area to the second area and controls the display 507 to display a warning signal when the ratio or difference changes beyond a change threshold.

It should be noted that the physiological detection system of the present embodiment may include more than two physiological detection devices to monitor different body parts, and the processing unit 45 controls the display 47 to prompt when the obtained three-dimensional energy distributions are unbalanced or have significant differences.

In other embodiments, the data of the skin shallow microcirculation blood vessel change can be detected by non-optical means, such as Doppler (Doppler) detection, so long as the resolution requirement can be met, for example, the sensing pixel size is preferably between 5×5 μm and 10×10 μm, and the sensing array size is preferably between 240×240 and 480×480, and is not limited to the optical detection means. That is, regardless of whether the physiological detection system includes a light source, the physiological detection system includes a sensing array and a processing unit. The sensing array is used for detecting array type microcirculation data of the dermis layer of the skin so as to reflect different skin area states at the same time; wherein the sensing array comprises a plurality of pixel areas. In the optical detection, the pixel areas are photosensitive pixels; in other detection modes, the pixel regions are corresponding sensing pixels. The processing unit is used for judging different microcirculation states according to the change of the array type microcirculation data along with time; wherein the variation includes, for example, a variation in the variation amount of the microcirculation data and a variation in the average value.

The present description is applicable to transdermal drug delivery system monitoring. The transdermal drug delivery system (transdermal drug delivery system) is an administration mechanism by which a drug is delivered through the skin at a certain rate after being delivered through the skin and absorbed by the microcirculation vessels and then enters the body's circulation to exert a drug effect. The advantages are that the first pass reaction of the liver and the damage of the gastrointestinal tract to the medicine can be avoided, and the effects of reducing the administration times, prolonging the time interval between the administrations, maintaining the effective blood concentration in the blood and the like can be achieved, so as to improve the curative effect.

The invention can be used for monitoring the absorption reaction of the microcirculation blood vessel to the medicine, and can judge that the percutaneous medicine release system is continuously in action when the amplitude change of the microcirculation blood vessel is increased and the heartbeat frequency is also increased. When the amplitude change, the heart beat frequency and the average amplitude value of the microcirculation blood vessel return to the past normal range, the percutaneous drug delivery system can be known to be already operated, and the follow-up treatment course, such as re-administration and the like, can be carried out. In other words, the array type physiological detection system described in the present invention can reflect the administration state of microcirculation through three-dimensional spectrum energy, and can display the administration effect.

Diseases such as atherosclerosis and peripheral neuropathy are easily caused in limbs of diabetics. Atherosclerosis can lead to ischemia and necrosis of tissue, peripheral neuropathy can lead to motor weakness and sensory loss. Since the microcirculation blood vessel is subjected to sympathetic nerve, monitoring the change of the microcirculation blood vessel can warn diabetics whether the diseases occur in early stage.

The invention can monitor the change of the microcirculation blood vessel, and when the microcirculation blood vessel of the diabetic patient shows that the amplitude change and the average value of the amplitude decrease along with the time, the blood vessel is gradually disabled. In other words, the array type physiological detection system described in the invention can reflect the degradation state of microcirculation through three-dimensional spectrum energy, and can display the focus degree.

The invention can also observe the microcirculation reaction of the patient when external stimulus is applied to the patient, for example, when the patient has peripheral neuropathy, external cold and hot stimulus is applied, and if the microcirculation presents amplitude change reduction and the heartbeat frequency is not increased, the peripheral nerve is inactive, and the pathological change is possible. In other words, the array type physiological detection system described in the invention can reflect the reaction state of microcirculation through three-dimensional spectrum energy, and can display nerve activity.

Patients suffering from burns and scalds easily suffer from hypovolemic shock, microcirculatory vascular fragility, increased permeability and the like due to the loss of skin protection in local areas. Because such conditions develop rapidly, multiple organ dysfunction syndrome may occur if rescue is not available. The invention can be used for monitoring the peripheral tissue circulation of a burn and scald patient, thereby monitoring the course change of the patient so as to avoid more dangerous conditions. In other words, the array type physiological detection system described in the invention can reflect the operation state of the microcirculation through the three-dimensional spectrum energy, and can display the course change.

The hyperbaric oxygen treatment is proved to be effective in improving tissue microcirculation after radiation irradiation in clinic, and has obvious curative effect on radioosteonecrosis or soft tissue necrosis. The patient can monitor the change of the treatment effect when receiving hyperbaric oxygen treatment by the invention, and when the amplitude change of the microcirculation blood vessel is increased and the heartbeat frequency is also increased, the microcirculation blood vessel gradually recovers the activity, and the treatment gradually generates effect. In other words, the array type physiological detection system described in the invention can reflect the recovery state of microcirculation through three-dimensional spectrum energy, and can display the treatment effect.

Shock is a progressive process in which when the circulatory system loses its ability to support the body's metabolism, resulting in insufficient perfusion of blood to body tissues or organs, oxygen delivered to the body is not fully utilized by the tissues of the body, so that abnormal cell metabolism occurs, causing cell damage or death. When a patient starts to get into shock, microcirculation vasodilation is caused, and blood is accumulated in the microcirculation, so that serious shock condition can be caused if the blood cannot be effectively removed.

By applying the invention, the effect can be synchronously observed when shock relieving treatment is carried out on the patient. If the average value of the amplitude signal of the microcirculation vessel is always shown to be quite high, and the amplitude variation of the amplitude signal is not high, and the heartbeat frequency is continuously maintained at a higher frequency, the effect of relieving treatment is not generated, and vice versa. In other words, the array type physiological detection system described in the present invention can reflect the recovery state of microcirculation through three-dimensional spectrum energy, which can show the alleviating effect.

There is typically heat failure and a heatstroke response in the exercise-excessive state. When the human body is in such a state, the blood circulation of the skin increases, and the blood transported by the heart also increases. When the blood is insufficient, the blood in the body can be redistributed, so that the blood circulation of internal organs is reduced, and the skin blood circulation is increased to assist perspiration and dissipate heat in the body. The invention can moderately remind the user that the user is possibly in a state of excessive exercise and is not suitable for continuous exercise when the average value of the amplitude signal of the microcirculation blood vessel is quite high and the amplitude variation of the amplitude signal is not high and the heartbeat frequency is continuously maintained at a higher frequency. In other words, the array type physiological detection system described in the invention can reflect the blood distribution state of microcirculation through three-dimensional spectrum energy, and can display the heat dissipation effect.

The microcirculation has the functions of regulating tissue blood flow, supplying cell nutrition, removing metabolic products and the like, and the local blood volume can represent relative temperature change, so that the relative change of the microcirculation temperature of peripheral tissues can be detected, and when the average value of the microcirculation blood vessel amplitude signals of the local tissues is high, the temperature is represented to be increased, and vice versa. In other words, the array type physiological detection system described in the invention can reflect the temperature state of the microcirculation through three-dimensional spectrum energy, and can display local blood volume.

So far, there is no effective portable end-to-circulation vascular test product available for autistic patient/infant/pet peripheral tissue sympathology tests. The walls of the arteries and arterioles in the microcirculation are composed of smooth muscles, which are innervated by sympathetic nerves, which control the opening and closing of the microcirculation, thereby determining the blood supply to the tissue. By the present invention, it is possible to indirectly infer the state of sympathetic activity by observing the trend of change in the last slightly circulating blood vessel. When the sympathetic nerves are active, the trend of the microcirculation blood vessels will also tend to be active, and vice versa. In other words, the array type physiological detection system described in the present invention can reflect the blood supply state of the microcirculation through three-dimensional spectrum energy, and can display the active state of the sympathetic nerves.

The description of the invention is also applicable to judging cardiac function or systemic vascular defects or sclerosis. After integrating all the shallow microvascular tone change signals into a single result, there will be different energies at different frequencies. Generally, the signal representing the energy should appear as a multiple of the heart rate while the signal energy is maintained in a normal interval that varies from person to person, but should not be so variable over time for the same user. Thus, if the signal representing the energy is present in an interval other than the frequency multiplication of the heart beat frequency, and for example when the energy of the signal deviates from the normal interval over time, there is an abnormality in the heart or blood vessel function representing the user, and further examination is required.

For example, when the signal representing energy is present in an interval outside the frequency multiplication of the heart beat frequency, it may represent a heart function defect of the user, such as a valve defect. When the energy of the signal exceeds the normal interval by a large amount over time, it may represent arteriosclerosis of the user, so that the heart needs to increase its output power to transport blood throughout the body. In other words, the array type physiological detection system described in the present invention can reflect the abnormal state of the microcirculation through the three-dimensional spectrum energy, which can display the heart function.

In the above description, the amplitude variation refers to a variation of the three-dimensional spectral energy, and the amplitude average value refers to an average value of the three-dimensional spectral energy; wherein the distribution of the three-dimensional spectral energy is similar to that of fig. 2D. In the above description, the effective number of pixels refers to the number of pixels within the WOI range of the observation window. The numerical values set forth in the illustrative examples of the present invention are intended to be illustrative only and are not intended to be limiting.

Although the present invention has been described in terms of the foregoing examples, it is not intended to limit the invention to the particular embodiments disclosed, but to limit the scope of the invention to such modifications and variations within the spirit and scope of the invention as defined by the appended claims. The scope of the invention is therefore defined by the appended claims.

Claims

1. A physiological testing device, comprising:

a light source module for emitting light of a first wavelength to illuminate a skin area, wherein the first wavelength is between 500 nanometers and 550 nanometers;

a photosensitive array for detecting outgoing light from the skin region and outputting a plurality of PPG signals; and

a processing unit for

Converting the plurality of PPG signals into a three-dimensional energy distribution,

Identifying a ring pattern in the three-dimensional energy distribution, wherein the ring pattern comprises at least one ring formed by energy values in the three-dimensional energy distribution that are greater than an energy threshold, and

when the ring pattern is confirmed, the three-dimensional energy distribution is represented to contain valid data.

2. The physiological testing apparatus of claim 1, wherein the physiological testing apparatus is further configured to provide alert information when the annular pattern is not identifiable.

3. The physiological detection device of claim 1 wherein the processing unit is further configured to control the light source module to emit light at a second wavelength that is greater than the first wavelength such that the photosensitive array detects the emitted light from different tissue depths.

4. The physiological detection device of claim 3, wherein the second wavelength is between 850 nanometers and 900 nanometers, or between 590 nanometers and 620 nanometers.

5. The physiological detection device of claim 3, wherein the processing unit is not configured to identify the annular pattern from a three-dimensional energy distribution associated with light of the second wavelength.

6. The physiological testing device of claim 1, wherein the processing unit is further configured to control a display to display information of a direction in which the physiological testing device is moved.

7. A physiological detection system, comprising:

a first array PPG detector for generating a plurality of first PPG signals;

a second array PPG detector for generating a plurality of second PPG signals; and

a processing unit for

Converting the first and second PPG signals into first and second three-dimensional energy distributions, respectively,

identifying a ring pattern in the first three-dimensional energy distribution and the second three-dimensional energy distribution, wherein the ring pattern comprises at least one ring formed by energy values in the first three-dimensional energy distribution and the second three-dimensional energy distribution that are greater than an energy threshold, and

when the first three-dimensional energy distribution and the second three-dimensional energy distribution respectively comprise the annular patterns, the physiological detection system is indicated to work normally.

8. The physiological detection system of claim 7, wherein

The first array PPG detector includes:

a first light source module for emitting light of a first wavelength to illuminate a first tissue region; a kind of electronic device with high-pressure air-conditioning system

A first photosensitive array for detecting outgoing light from the first tissue region and outputting the plurality of first PPG signals;

The second array PPG detector includes:

a second light source module for emitting light of a second wavelength to illuminate a second tissue region; a kind of electronic device with high-pressure air-conditioning system

And a second photosensitive array for detecting the emergent light from the second tissue region and outputting the plurality of second PPG signals.

9. The physiological detection system of claim 8, wherein the first wavelength is between 500 nanometers and 550 nanometers.

10. The physiological detection system of claim 8, wherein the first tissue region is located at a user's hand and the second tissue region is located at a different skin surface of the user.

11. The physiological detection system of claim 7, wherein the processing unit is built into the first or second array PPG detector.

12. The physiological detection system of claim 7, wherein the processing unit is further configured to continuously monitor changes in the first three-dimensional energy distribution and the second three-dimensional energy distribution over time after the annular pattern is confirmed in the first three-dimensional energy distribution and the second three-dimensional energy distribution.

13. A physiological testing device, comprising:

a light source module comprising a plurality of light emitting diodes for illuminating a tissue region with light of a first wavelength emitted by different groups of the plurality of light emitting diodes, wherein the first wavelength is between 500 nanometers and 550 nanometers;

A photosensitive array for detecting outgoing light from the tissue region and outputting a plurality of PPG signals; and

a processing unit for

identifying a ring pattern in the three-dimensional energy distribution obtained when the first set of light emitting diodes is illuminated, wherein the ring pattern comprises at least one ring formed by energy values in the three-dimensional energy distribution that are greater than an energy threshold, and

when the annular pattern is not recognized in the three-dimensional energy distribution, the self-adjustment is performed before prompting the user to manually adjust the information.

14. The physiological testing apparatus of claim 13, wherein the processing unit is further configured to control the light source module to emit light at a second wavelength that is greater than the first wavelength when the ring-shaped pattern is identified in the three-dimensional energy distribution associated with the first set of light emitting diodes.

15. The physiological detection device of claim 14, wherein the second wavelength is between 850 nanometers and 900 nanometers, or between 590 nanometers and 620 nanometers.

16. The physiological testing apparatus of claim 13, wherein the self-adjusting includes:

Controlling the lighting of a second group of LEDs at different positions, or

Changing a window of interest in an image frame acquired by the photosensitive array.