Disclosure of Invention
Object of the Invention
The invention aims to provide a pesticide composition and application thereof, and solves the problem that pyrethroid pesticides bring irritation to experimenters, production personnel and farmers such as skin abnormal itching, red swelling and the like when in use. The trans-tert-butyl cyclohexanol is added into the pesticide, so that the anti-allergic effect is solved to the greatest extent, meanwhile, insect pests of crops are prevented and treated, the synergistic effect is achieved, the quality and yield of the crops are improved, the crop pollution caused by the pesticide can be effectively avoided, and the grain safety is ensured.
Solution scheme
In order to achieve the aim of the invention, the embodiment of the invention provides a pesticide composition, which comprises the following raw materials in parts by weight: 1-99 parts of lambda-cyhalothrin, 1-99 parts of chlorantraniliprole and 1-50 parts of trans-tert-butylcyclohexanol.
Further, the material comprises the following raw materials in parts by weight: 1-80 parts of lambda-cyhalothrin, 5-80 parts of chlorantraniliprole and 1-40 parts of trans-tert-butylcyclohexanol; alternatively, the trans-tert-butylcyclohexanol is trans-4-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 2-60 parts of lambda-cyhalothrin, 5-40 parts of chlorantraniliprole and 1-30 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 4-30 parts of lambda-cyhalothrin, 5-25 parts of chlorantraniliprole and 2-30 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 5-8 parts of lambda-cyhalothrin, 7-15 parts of chlorantraniliprole and 3-15 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 6.3-8 parts of lambda-cyhalothrin, 12.4-15 parts of chlorantraniliprole and 5-15 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 6.3-8 parts of lambda-cyhalothrin, 12.4-15 parts of chlorantraniliprole and 6-10 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 6.3-8 parts of lambda-cyhalothrin, 12.4-15 parts of chlorantraniliprole and 6 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 6.3 parts of lambda-cyhalothrin, 12.4 parts of chlorantraniliprole and 5-6 parts of trans-tert-butylcyclohexanol;
optionally, the material comprises the following raw materials in parts by weight: 6.3 parts of lambda-cyhalothrin, 12.4 parts of chlorantraniliprole and 6 parts of trans-tert-butylcyclohexanol.
Further, the trans-tert-butylcyclohexanol is trans-4-tert-butylcyclohexanol.
Further, the weight ratio of the lambda-cyhalothrin to the chlorantraniliprole is 1:1-3, optionally 1:1.5-2.5, optionally 1:1.8-2.1.
Further, the high-efficiency cyhalothrin, chlorantraniliprole and trans-tert-butylcyclohexanol account for 10-50%, alternatively 11-40%, alternatively 15-38%, alternatively 20-30%, alternatively 23-26%, alternatively 24.7% of the total weight of the composition.
Further, the water-based paint further comprises an auxiliary agent, wherein the auxiliary agent is one or more selected from dispersing agents, wetting agents, emulsifying agents, stabilizing agents, antifreezing agents, defoaming agents, preservatives, thickening agents, solvents, organic acids and dispersing media;
further, the thickener is at least one selected from polyvinylpyrrolidone, xanthan gum, magnesium aluminum silicate, polyvinyl alcohol and polyvinyl acetate;
optionally, the dispersing agent is at least one selected from maleic acid-acrylic acid copolymer sodium salt, castor oil polyoxyethylene ether, methylene dinaphthyl sulfonate, sodium lignin sulfonate, calcium lignin sulfonate, sodium dodecyl benzene sulfonate, calcium dodecyl benzene sulfonate, sodium succinate sulfonate, nekal, sodium lignin sulfonate, sodium lauryl sulfate, sodium alkyl sulfonate, sodium dodecyl sulfate, nonylphenol polyoxyethylene ether and fatty alcohol polyoxyethylene ether; castor oil polyoxyethylene ether is preferred;
optionally, the antifreezing agent is at least one selected from ethylene glycol, propylene glycol and glycerol;
optionally, the organic acid is at least one selected from formic acid, acetic acid, propionic acid, butyric acid, caprylic acid, adipic acid and oxalic acid.
Further, the formulation of the composition is at least one of missible oil, water emulsion, microemulsion, suspending agent, water dispersible granule and microcapsule suspending agent; preferably a suspending agent or water emulsion; suspending agents are preferred.
In another aspect, there is provided the use of the pesticidal composition for controlling plant pests.
Further, the plant insect pest comprises at least one of corn leaf worm, corn borer, aphid, armyworm, spider mite, laodelphax striatellus, chafer, leafhopper, thrips, cotton bollworm, peach fruit borer and cabbage caterpillar; preferably comprises corn leaf worm, corn borer, armyworm, aphid, corn leaf mite, laodelphax striatellus, scara, thrips.
In still another aspect, a method for using the pesticide composition is provided, wherein the pesticide composition is sprayed for 1 time in the large horn mouth period and the bud period of corn, and the dilution ratio of the pesticide composition to water is 1000-1500 times.
Advantageous effects
According to the invention, the trans-tert-butylcyclohexanol is selected and added into the pesticide, so that the irritation trouble of abnormal skin itching, red swelling and the like caused by the high-efficiency cyhalothrin to the experimenters, production personnel and farmers during use is effectively relieved, the influence of antiallergic effect is solved to the maximum extent, meanwhile, the insect pest of crops is prevented and controlled, the pollution of the crops by the pesticide can be effectively avoided, and the grain safety is ensured.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. Throughout the specification and claims, unless explicitly stated otherwise, the term "comprise" or variations thereof such as "comprises" or "comprising", etc. will be understood to include the stated element or component without excluding other elements or components.
In addition, numerous specific details are set forth in the following description in order to provide a better illustration of the invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In some embodiments, materials, elements, methods, means, etc. well known to those skilled in the art are not described in detail in order to highlight the gist of the present invention.
The high-efficiency cyhalothrin and chlorantraniliprole of the invention are both purchased from Jiangsu threo group Co., ltd, the trans-4-tertiary butyl cyclohexanol is purchased from Shanghai Jiang Lai organism, the antipruritic agent T-90 is purchased from Hebei Xinrui biosciences Co., ltd, and the antipruritic agent G-200 Shenzhen Daqian biosciences Co., ltd.
Example 1
18.7% high-efficiency cyhalothrin chlorantraniliprole suspending agent
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 6 weight percent of trans-4-tertiary butyl cyclohexanol, 1.5 weight percent of castor oil polyoxyethylene ether, 0.35 weight percent of xanthan gum, 0.5 weight percent of defoaming agent, 3 weight percent of glycol, 0.05 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Example 2
18.7% efficient cyhalothrin chlorantraniliprole microemulsion
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 5 weight percent of trans-4-tertiary butyl cyclohexanol, 2 weight percent of sodium dodecyl benzene sulfonate, 1.5 weight percent of castor oil polyoxyethylene ether, 3 weight percent of glycol, 5 weight percent of cyclohexanone and 100 weight percent of water are taken.
Example 3
18.7% high-efficiency cyhalothrin-chlorantraniliprole water emulsion
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 6 weight percent of trans-4-tertiary butyl cyclohexanol, 6 weight percent of dimethylbenzene, 5 weight percent of cyclohexanone and 0.5 weight percent of glacial acetic acid are taken, and the water is added to 100 weight percent.
Example 4
18.7% high-efficiency cyhalothrin chlorantraniliprole wettable powder
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 4 weight percent of trans-4-tertiary butyl cyclohexanol, 3 weight percent of sodium lauryl sulfate, 2 weight percent of nonylphenol polyoxyethylene ether and 100 weight percent of kaolin are taken.
Example 5
18.7% high-efficiency cyhalothrin chlorantraniliprole dispersible granule
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 3 weight percent of trans-4-tertiary butyl cyclohexanol, 3 weight percent of sodium lignin sulfonate, 1.5 weight percent of sodium sulfonyl succinate and 100 weight percent of white carbon black are taken.
Comparative example 1
18.7% high-efficiency cyhalothrin chlorantraniliprole suspending agent
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 12.4 weight percent of antipruritic agent T-90, 2 weight percent of fatty alcohol polyoxyethylene ether phosphate, 3 weight percent of dialkyl naphthalene carboxylate, 1.5 weight percent of castor oil polyoxyethylene ether, 0.35 weight percent of xanthan gum, 0.5 weight percent of defoaming agent, 3 weight percent of glycol, 0.05 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Comparative example 2
18.7% high-efficiency cyhalothrin chlorantraniliprole suspending agent
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 12.4 weight percent of antipruritic agent G-200, 2 weight percent of fatty alcohol polyoxyethylene ether phosphate, 3 weight percent of dialkyl naphthalene carboxylate, 1.5 weight percent of castor oil polyoxyethylene ether, 0.35 weight percent of xanthan gum, 0.5 weight percent of defoamer, 3 weight percent of glycol, 0.05 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Comparative example 3
18.7% high-efficiency cyhalothrin chlorantraniliprole suspending agent
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 2 weight percent of fatty alcohol polyoxyethylene ether phosphate, 3 weight percent of dialkyl naphthalene carboxylate, 1.5 weight percent of castor oil polyoxyethylene ether, 0.35 weight percent of xanthan gum, 0.5 weight percent of defoamer, 3 weight percent of glycol, 0.05 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Comparative example 4
18.7% efficient cyhalothrin chlorantraniliprole microemulsion
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 5 weight percent of antipruritic agent T-90, 2 weight percent of sodium dodecyl benzene sulfonate, 3 weight percent of bisphenol polyoxyethylene ether phosphate, 1.5 weight percent of castor oil polyoxyethylene ether, 3 weight percent of glycol, 5 weight percent of cyclohexanone and 100 weight percent of water are taken.
Comparative example 5
18.7% efficient cyhalothrin chlorantraniliprole microemulsion
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 2 weight percent of sodium dodecyl benzene sulfonate, 3 weight percent of bisphenol polyoxyethylene ether phosphate, 1.5 weight percent of castor oil polyoxyethylene ether, 3 weight percent of glycol, 5 weight percent of cyclohexanone and 100 weight percent of water are taken.
Comparative example 6
18.7% efficient cyhalothrin chlorantraniliprole microemulsion
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 2 weight percent of sodium dodecyl benzene sulfonate, 3 weight percent of bisphenol polyoxyethylene ether phosphate, 1.5 weight percent of castor oil polyoxyethylene ether, 3 weight percent of glycol, 5 weight percent of cyclohexanone and 100 weight percent of water are taken.
Comparative example 7
18.7% high-efficiency cyhalothrin-chlorantraniliprole water emulsion
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 12.4 weight percent of antipruritic agent T-90 weight percent, 2 weight percent of fatty acid polyoxyethylene ester, 1.5 weight percent of EO-PO-EO, 6 weight percent of dimethylbenzene, 5 weight percent of cyclohexanone, 0.5 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Comparative example 8
18.7% high-efficiency cyhalothrin-chlorantraniliprole water emulsion
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 12.4 weight percent of antipruritic agent G-200 weight percent, 2 weight percent of fatty acid polyoxyethylene ester, 1.5 weight percent of EO-PO-EO, 6 weight percent of dimethylbenzene, 5 weight percent of cyclohexanone, 0.5 weight percent of glacial acetic acid and 100 weight percent of water are taken.
Comparative example 9
18.7% high-efficiency cyhalothrin-chlorantraniliprole water emulsion
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 2 weight percent of fatty acid polyoxyethylene ester, 1.5 weight percent of EO-PO-EO, 6 weight percent of dimethylbenzene, 5 weight percent of cyclohexanone and 0.5 weight percent of glacial acetic acid are taken, and the water is added to 100 weight percent.
Comparative example 10
18.7% high-efficiency cyhalothrin chlorantraniliprole wettable powder
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 5 weight percent of lauryl sodium sulfate, 3 weight percent of nonylphenol polyoxyethylene ether and 100 weight percent of kaolin are taken.
Comparative example 11
18.7% high-efficiency cyhalothrin chlorantraniliprole wettable powder
6.3 weight percent of high-efficiency cyhalothrin, 12.4 weight percent of chlorantraniliprole, 5 weight percent of lauryl sodium sulfate, 3 weight percent of nonylphenol polyoxyethylene ether and 100 weight percent of kaolin are taken.
Comparative example 12
18.7% high-efficiency cyhalothrin chlorantraniliprole wettable powder
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 4 weight percent of lauryl sodium sulfate, 3 weight percent of nonylphenol polyoxyethylene ether and 100 weight percent of kaolin are taken.
Comparative example 13
18.7% high-efficiency cyhalothrin chlorantraniliprole dispersible granule
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 6 weight percent of sodium lignin sulfonate, 1.5 weight percent of sodium sulfonyl succinate and 100 weight percent of white carbon black are taken.
Comparative example 14
18.7% high-efficiency cyhalothrin chlorantraniliprole dispersible granule
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 6 weight percent of sodium lignin sulfonate, 1.5 weight percent of sodium sulfonyl succinate and 100 weight percent of white carbon black are taken.
Comparative example 15
18.7% high-efficiency cyhalothrin chlorantraniliprole dispersible granule
6.3 weight percent of lambda-cyhalothrin, 12.4 weight percent of chlorantraniliprole, 6 weight percent of sodium lignin sulfonate, 1.5 weight percent of sodium sulfonyl succinate and 100 weight percent of white carbon black are taken.
Test example 1
Test item: multiple/acute skin irritation verification
The test method comprises the following steps: white rabbits (male/female), weight 2.0-3.0 kg;
acute skin irritation test: about 24 hours before the test, removing the fur on two sides of the back spine of the experimental animal, and removing the fur within the scope of not damaging the epidermisAt least 6cm each 2 ;
0.5mL (g) of the test substance was applied to one side of dehaired skin, covered with two layers of gauze and one layer of cellophane or the like, and fixed with non-irritating adhesive tape and bandage. The other side of the skin served as a control, and the other treatments were identical to the test side, except that no test was applied. The skin reaction at the smearing part is observed 24h, 48h and 72h after the test object is cleared, and the observation can be stopped after the stimulus reaction is not seen or completely recovered for 72 h. The observation should be continued daily until the skin reaction is not restored, and the observation time should be determined to be sufficient to observe the whole course of reversible or irreversible stimulation, generally not exceeding 14d. Skin response scores were performed as shown in Table 1, the total evaluation was performed as the average of the scores of the test animals, the skin irritation intensities were determined as shown in Table 2 based on the average of the highest scores at the observation time points of 24 hours, 48 hours, 72 hours, etc., and the detection results were shown in Table 3.
The antiallergic compositions obtained in examples 1 to 5 and comparative examples 1 to 15 were classified in terms of skin irritation response score and skin irritation intensity of rabbits, and the investigation method was referred to "GB/T15670 method for registered toxicology test".
TABLE 1 skin irritation response score
TABLE 2 skin irritation intensity grading
Grading
|
Integral mean value
|
No irritation
|
0-<0.5
|
Mild irritation
|
0.5-<2.0
|
Moderate irritation
|
2.0-<6.0
|
Strong irritation
|
6.0-<8.0
|
Corrosiveness of
|
At least one of the irreversible skin damage and structural damage occurs, and the skin fails to recover within 14d |
TABLE 3 skin irritation response score and irritation intensity of pesticidal compositions for rabbits
As can be seen from Table 3, the pesticide composition provided by the invention has good effects on the skin irritation response score and the irritation intensity of rabbits, wherein examples 1-5 are non-irritating to skin tests, and comparative examples are local competitive antipruritic agents and blank controls, and are irritating to the skin of rabbits.
Test example 2
Test item: acute eye irritation/corrosiveness test
The test method comprises the following steps: white rabbits (male/female), weight 2.0-3.0 kg;
acute eye irritation test: within 24 hours prior to the test, both eyes of the experimental animals were examined (including examination with sodium fluorescein) and animals with redness, inflammation, and ocular defects and corneal lesions were not used in the test.
The lower eyelid of the eye on one side of the rabbit was gently pulled open, and 0.1mL (or 100 mg) of the test substance was dropped into the conjunctival sac of the human, and the upper and lower eyelids were passively closed for 1s to prevent the test substance from being lost. The other eye was not treated as a self-control. Generally, eyes are not washed within 24 hours after the test object is dripped; the eyes of the animals were examined 1h, 24h, 48h, 72h, and day 4 and day 7 after dropping (putting) the test object. If the stimulus response does not appear or the stimulus response is completely restored for 72 hours, the test can be terminated. In addition to observations of cornea, iris, conjunctiva, other damaging effects should be recorded and reported. The scores of eye irritation response should be recorded in each examination according to the scoring criteria for eye damage of table 1.
The eye irritation response test may be performed using a magnifying glass, a hand-held slit lamp, a stereoscopic microscope, or other suitable instrument device. After 24h observation and recording was completed, eyes of all animals were further examined using sodium fluorescein (1% -2% concentration).
Animals such as those with corneal perforation, corneal ulcer, anterior chamber hemorrhage, and corneal haze for more than 48 hr. Lack of light reflection (iris response 2 minutes) beyond 72 hours, conjunctival ulcers, necrosis, etc., usually as an indication of irreversible damage, should be given to humane sacrifice.
The antiallergic compositions obtained in examples 1 to 5 and comparative examples 1 to 15 were subjected to scoring of eye damage of rabbits (scoring criteria are shown in Table 4) and classification of eye irritation response (classification criteria are shown in Table 5), and the investigation method was referred to "GB/T15670 method for toxicological test registration", and the scoring results are shown in tables 6 and 7.
TABLE 4 scoring criteria for ocular lesions
TABLE 5 grading of ocular stimulatory responses
Grading
|
Stimulus response
|
No irritation
|
None of the animals tested showed eye irritation response
|
Mild irritation
|
The conjunctiva of the tested animal showed slight irritation response, all responses were completely recovered within 24h
|
Moderate irritation
|
More than 1 (including 1) tested animal has cornea injury or other eye irritation reaction, and all the reactions are completely recovered within less than or equal to 7d
|
Strong irritation
|
More than 1 animal (containing 1 animal) has cornea injury or other eye irritation reaction, and all the reactions are completely recovered within 8-21 d
|
Corrosiveness of
|
Cornea, iris and/or conjunctival irritation responses of any 1 animal were not completely restored during the 21d observation period |
Table 6 pesticide composition scoring of damage to rabbit eyes
TABLE 7 grading of pesticide composition on eye irritation response of Rabbit
As can be seen from tables 6 and 7, the pesticide composition of the present invention has good effects on damage and irritation response of rabbit eyes, wherein examples 1 to 5 have no irritation to rabbit eyes, and comparative examples are local competitive antipruritic and blank control, and have irritation to rabbit eyes.
Test example 3
The antiallergic compositions obtained in examples 1 to 5 and comparative examples 1 to 15 were tested for their efficacy against corn pest control (corn leaf rollers, corn borers, armyworms, aphids, corn spider mites, brown planthoppers, scarves, thrips) in combination.
Test site: a farm household field in the city of chat, mountain east and county Cheng Haicun
Selecting a serious disease and pest area of corn, diluting the medicaments prepared in examples 1-5 and the medicaments prepared in comparative examples 1-15 with 1500 times of water, spraying the medicaments for 1 time in the large horn mouth period and the bud period of the corn respectively, and spraying the medicaments until the medicaments start to drop to the leaves. The test cell length was approximately 15-20m, 3 replicates per treatment. Investigation was performed 20 days after dosing in the bud stage. 100 corn plants are investigated in each district, the number of the harmful plants is counted, the corn pest control effect is investigated, the investigation method refers to GB/T17980 pesticide field efficacy test criterion, the control effect is calculated according to the formula (1) and the formula (2), and the result is shown in Table 8.
(1)
(2)
Table 8 corn pest control field test results
From Table 8, it can be seen that the pesticide composition provided by the invention has good control effect on corn insect pests. The compound pesticide composition of the embodiment 1 has remarkable control effects on corn leaf miners, corn borers, armyworms, aphids, corn spider mites, laodelphax striatellus, chafer and thrips.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.