CN114222571A - 索格列净治疗患2型糖尿病和中度肾损害的患者的用途 - Google Patents
索格列净治疗患2型糖尿病和中度肾损害的患者的用途 Download PDFInfo
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- CN114222571A CN114222571A CN202080053637.0A CN202080053637A CN114222571A CN 114222571 A CN114222571 A CN 114222571A CN 202080053637 A CN202080053637 A CN 202080053637A CN 114222571 A CN114222571 A CN 114222571A
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 39
- 206010062237 Renal impairment Diseases 0.000 title claims abstract description 15
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- OBWASQILIWPZMG-QZMOQZSNSA-N empagliflozin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=CC=C(Cl)C(CC=2C=CC(O[C@@H]3COCC3)=CC=2)=C1 OBWASQILIWPZMG-QZMOQZSNSA-N 0.000 description 1
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- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19188477.4 | 2019-07-25 | ||
| EP19188477.4A EP3769767A1 (en) | 2019-07-25 | 2019-07-25 | Use of sotagliflozin for the treatment of patients with type 2 diabetes mellitus and moderate renal impairment |
| PCT/IB2020/057016 WO2021014420A1 (en) | 2019-07-25 | 2020-07-24 | Use of sotagliflozin for the treatment of patients with type 2 diabetes mellitus and moderate renal impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114222571A true CN114222571A (zh) | 2022-03-22 |
Family
ID=67438963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080053637.0A Withdrawn CN114222571A (zh) | 2019-07-25 | 2020-07-24 | 索格列净治疗患2型糖尿病和中度肾损害的患者的用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220265690A1 (https=) |
| EP (2) | EP3769767A1 (https=) |
| JP (1) | JP2022541322A (https=) |
| CN (1) | CN114222571A (https=) |
| AU (1) | AU2020319164A1 (https=) |
| CA (1) | CA3148400A1 (https=) |
| WO (1) | WO2021014420A1 (https=) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173335B2 (en) | 2006-07-14 | 2012-05-08 | The Trustees Of The University Of Pennsylvania | Beam ablation lithography |
-
2019
- 2019-07-25 EP EP19188477.4A patent/EP3769767A1/en not_active Ceased
-
2020
- 2020-07-24 JP JP2022504622A patent/JP2022541322A/ja active Pending
- 2020-07-24 EP EP20747477.6A patent/EP4003366A1/en not_active Withdrawn
- 2020-07-24 WO PCT/IB2020/057016 patent/WO2021014420A1/en not_active Ceased
- 2020-07-24 AU AU2020319164A patent/AU2020319164A1/en not_active Abandoned
- 2020-07-24 CA CA3148400A patent/CA3148400A1/en active Pending
- 2020-07-24 CN CN202080053637.0A patent/CN114222571A/zh not_active Withdrawn
- 2020-07-24 US US17/629,166 patent/US20220265690A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| B ZAMBROWICZ 等: ""LX4211, a Dual SG LT1/SG LT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial"", 《CLINICAL TRIAL》, vol. 92, no. 2, pages 158 - 169, XP055193077, DOI: 10.1038/clpt.2012.58 * |
| BRIAN ZAMBROWICZ 等: ""LX4211 Therapy Reduces Postprandial Glucose Levels in Patients With Type 2 Diabetes Mellitus and Renal Impairment Despite Low Urinary Glucose Excretion"", 《CLINICAL THERAPEUTICS》, vol. 37, no. 1, pages 71 - 82 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021014420A1 (en) | 2021-01-28 |
| AU2020319164A1 (en) | 2022-02-24 |
| EP3769767A1 (en) | 2021-01-27 |
| EP4003366A1 (en) | 2022-06-01 |
| CA3148400A1 (en) | 2021-01-28 |
| US20220265690A1 (en) | 2022-08-25 |
| JP2022541322A (ja) | 2022-09-22 |
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